Добірка наукової літератури з теми "Pathobiont"
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Статті в журналах з теми "Pathobiont":
Gilliland, A., Y. Chen, D. Tertigas, M. Surette, B. Bressler, and B. Vallance. "A24 AN ULCERATIVE COLITIS-ISOLATED PATHOBIONT CAN DEGRADE MUCUS PRODUCED BY UC PATIENT-DERIVED COLONOIDS." Journal of the Canadian Association of Gastroenterology 7, Supplement_1 (February 14, 2024): 13–14. http://dx.doi.org/10.1093/jcag/gwad061.024.
Jones, Josh, Qiaojuan Shi, Rahul R. Nath, and Ilana L. Brito. "Keystone pathobionts associated with colorectal cancer promote oncogenic reprograming." PLOS ONE 19, no. 2 (February 16, 2024): e0297897. http://dx.doi.org/10.1371/journal.pone.0297897.
Minton, Kirsty. "Pathobiont peacekeepers." Nature Reviews Immunology 18, no. 3 (February 16, 2018): 152. http://dx.doi.org/10.1038/nri.2018.11.
Yang, H., H. Mirsepasi-Lauridsen, C. Struve, J. M. Allaire, A. Sivignon, W. Vogl, E. S. Bosman, et al. "A21 ULCERATIVE COLITIS-ASSOCIATED E. COLI PATHOBIONTS POTENTIATE COLITIS IN SUSCEPTIBEL HOSTS." Journal of the Canadian Association of Gastroenterology 4, Supplement_1 (March 1, 2021): 142–44. http://dx.doi.org/10.1093/jcag/gwab002.020.
Clayton, C., K. Ng, and C. Tropini. "A38 EXPLORING HOW BOWEL PREPARATION CAN AFFECT INFLAMMATORY BOWEL DISEASE VIA THE GUT MICROBIOTA." Journal of the Canadian Association of Gastroenterology 7, Supplement_1 (February 14, 2024): 21–22. http://dx.doi.org/10.1093/jcag/gwad061.038.
Chapman, Timothy J., Matthew C. Morris, Lei Xu, and Michael E. Pichichero. "Nasopharyngeal colonization with pathobionts is associated with susceptibility to respiratory illnesses in young children." PLOS ONE 15, no. 12 (December 11, 2020): e0243942. http://dx.doi.org/10.1371/journal.pone.0243942.
Yang, Hyungjun, Hengameh Chloé Mirsepasi-Lauridsen, Carsten Struve, Joannie M. Allaire, Else Bosman, Adeline Sivignon, Wayne Vogl, et al. "Ulcerative Colitis-associated E. coli pathobionts potentiate colitis in susceptible hosts." Journal of Immunology 202, no. 1_Supplement (May 1, 2019): 192.3. http://dx.doi.org/10.4049/jimmunol.202.supp.192.3.
Yang, H., X. Han, C. Ma, H. Yu, and B. Vallance. "A15 GENETIC OR DIET-ASSOCIATED DEFECTS IN MUCUS FACILITATE ULCERATIVE COLITIS PATHOBIONT-DRIVEN COLITIS." Journal of the Canadian Association of Gastroenterology 6, Supplement_1 (March 1, 2023): 8–9. http://dx.doi.org/10.1093/jcag/gwac036.015.
Fine, Rebecca, Silvio Manfredo Vieira, Daniel Fernando Zegarra Ruiz, and Martin A. Kriegel. "Gut pathobiont translocation induces lymphocyte migration to internal organs in autoimmunity." Journal of Immunology 200, no. 1_Supplement (May 1, 2018): 102.16. http://dx.doi.org/10.4049/jimmunol.200.supp.102.16.
Jochum, Lara, and Bärbel Stecher. "Label or Concept – What Is a Pathobiont?" Trends in Microbiology 28, no. 10 (October 2020): 789–92. http://dx.doi.org/10.1016/j.tim.2020.04.011.
Дисертації з теми "Pathobiont":
Jan, Alan. "Accélérer la restauration du microbiote intestinal pour renforcer la résistance à la colonisation contre les entérocoques résistants à la vancomycine." Electronic Thesis or Diss., université Paris-Saclay, 2023. http://www.theses.fr/2023UPASB087.
The gastrointestinal tract is a reservoir of opportunistic pathogens or pathobionts, which benefit from dysbiosis to proliferate in fragilised patients. VRE originate from the gastrointestinal tract, where their proliferation precedes dissemination in the bloodstream, and may lead to systemic infection. Understanding the mechanisms responsible for resistance to intestinal colonisation by VRE is essential for infection control. Only few studies have identified commensal bacteria that enhance resistance to colonisation of the microbiota against VRE. I aimed to identify commensal bacteria, key in the barrier effect to accelerate gut microbiota recovery after antibiotic dysbiosis to enhance resistance to colonisation against VRE. I performed a longitudinal analysis of the gut microbiota composition and VRE carriage levels during microbiota recovery in mice colonised with VRE after antibiotic-induced dysbiosis. By combining biological data and mathematical modelling, I identified 15 molecular species (OTUs) that correlate negatively with VRE carriage. Six strains representative of these OTUs have been collected and used in mixture with a seventh strain (Mix7) in two different mice lines challenged with VRE. I found that Mix7 allows a reduction of VRE carriage and a better gut microbiota recovery. Differences in the effect of Mix7 between mice were observed with responder and non-responder mice. These differences were associated with variation in the composition during the recovery and of the initial microbiota, providing potential biomarkers to predict response to Mix7. Furthermore, the Bacteroidota strain is required for Mix7 effect in vivo in the presence of at least one of the 6 other strains. In a mice model of alternative stable state of dysbiosis, higher concentrations were observed in responder compared to non-responder and control mice for short-chain fatty acids (acetate, propionate, butyrate) and for a number of metabolites including bile acids. None of the supernatant of the 7 strains, alone or in combination, inhibits VRE growth in vitro. Interestingly, 5 of the 7 strains are shared between human and mice and 2 have human functional equivalents. I showed that supplementation with a mixture of strains identified through mathematical modelling improves the barrier effect against VRE through mechanisms dependent of the recovery and initial composition of the microbiota. Ultimately, this work will allow to move towards a personalised medicine by targeting patients at risk and susceptible to respond to the supplementation with commensal anti-VRE strains, providing novel lived biotherapeutic products and biomarkers to predict response to treatment. The perspectives are 1/ to extend the effect to E. faecium for which I have adapted a colonisation model, 2/ to better understand the mechanism by implementing hypotheses thanks to metabolic modelling and using the culture medium that I have developed allowing the growth of 7 strains and the VRE, 3/ to explore the representation of the key species in the barrier effect in human microbiome database and 4/ to isolate human strains of these key species
Larousse, Marie. "Étude de l’interaction entre Phytophthora parasitica et le microbiote rhizosphérique à la surface de la plante hôte Solanum lycopersicum." Thesis, Nice, 2016. http://www.theses.fr/2016NICE4038.
The interactions between a pathogen and the host surface resident microbiota are critical to disease outbreak. These interactions shape the distribution, the density and the genetic diversity of inoculum. However for most plant pathogens how each of these interactions acts on disease as a single one or as a member of a functional network remains to be specified. This issue is addressed here through the analysis of two types of interactions involving the polyphagous oomycete P.parasitica : (i) the intraspecific interaction that leads to monospecific biofilm formation by P. parasitica zoospores on plant surface; (ii) the interspecific interactions that occur between P. parasitica biofilm and the prokaryotic microbiota of Solanum lycopersicum rhizosphere. The biology of monospecific biofilm is investigated through the characterization of MUCL, a new oomycete-specific Mucin-like Protein family. Gene profiling, biochemical and immunohistological analyses define the extent of this family and lead to identify three members, PPMUCL1/2/3, as residing in P. parasitica biofilm. The Phytophthora parasitica-Microbiota interaction is explored using first a metagenomic approach. Two microbial metagenomes derived from a soil of a tomato greenhouse is defined and compared after 16S RNA gene sequencing: M1 which corresponds to the sub-rhizospheric microbiota able to colonize the roots of axenic tomato seedlings; M2, the sub-microbiota able to colonize the tomato seedling roots previously coated with P. parasitica monospecific biofilm. A representative collection of microorganisms from M2 were also obtained through in vitro selection on a medium prepared from P. parasitica extract
Larousse, Marie. "Étude de l’interaction entre Phytophthora parasitica et le microbiote rhizosphérique à la surface de la plante hôte Solanum lycopersicum." Electronic Thesis or Diss., Nice, 2016. http://www.theses.fr/2016NICE4038.
The interactions between a pathogen and the host surface resident microbiota are critical to disease outbreak. These interactions shape the distribution, the density and the genetic diversity of inoculum. However for most plant pathogens how each of these interactions acts on disease as a single one or as a member of a functional network remains to be specified. This issue is addressed here through the analysis of two types of interactions involving the polyphagous oomycete P.parasitica : (i) the intraspecific interaction that leads to monospecific biofilm formation by P. parasitica zoospores on plant surface; (ii) the interspecific interactions that occur between P. parasitica biofilm and the prokaryotic microbiota of Solanum lycopersicum rhizosphere. The biology of monospecific biofilm is investigated through the characterization of MUCL, a new oomycete-specific Mucin-like Protein family. Gene profiling, biochemical and immunohistological analyses define the extent of this family and lead to identify three members, PPMUCL1/2/3, as residing in P. parasitica biofilm. The Phytophthora parasitica-Microbiota interaction is explored using first a metagenomic approach. Two microbial metagenomes derived from a soil of a tomato greenhouse is defined and compared after 16S RNA gene sequencing: M1 which corresponds to the sub-rhizospheric microbiota able to colonize the roots of axenic tomato seedlings; M2, the sub-microbiota able to colonize the tomato seedling roots previously coated with P. parasitica monospecific biofilm. A representative collection of microorganisms from M2 were also obtained through in vitro selection on a medium prepared from P. parasitica extract
Romano, Sara. "Dynamique des populations et communautés bactériennes au cours de l’hospitalisation et des infections associées aux soins : cas particulier de la chirurgie cardiaque." Thesis, Montpellier, 2015. http://www.theses.fr/2015MONT3515.
Human microbiota are now considered as supplementary organs involved in diseases such as infections. Microbiota disequilibrium named dysbiosis creates impaired ecological niches (pathobiomes). This new paradigm of infection is particularly relevant for opportunistic infections. In this study, we consider one major type of healthcare associated infection (HAI), the surgical site infections after cardiothoracic surgery as a pathology of niche. We study the dynamics of microbial communities and populations as conditions for emergence and success of infectious agents.The diversity and dynamics of superficial and deep surgical microbiota in patients undergoing coronary artery bypass grafting show a partial replacement of the pre-operative microbiota by a specific surgical microbiota with partial resilience during healing. Significant links are found between microbiota composition and scores for infectious risk. The population structure of Propionibacterium acnes, a pathogen complicating cardiac surgery, shows variable frequencies of phylotypes according to operative stages. Surgical microbiota appears specific with high diversity of Gram-negative bacteria, some of them being previously described in healthy skin microbiota. At the species-level, these bacteria appear atypical among known human bacteria because they are related to environmental bacteria. We demonstrate the cutaneous reservoir of the opportunistic pathogen Roseomonas mucosa deemed, until now, to be environmental. Three populations of opportunistic pathogens (Pseudomonas aeruginosa, Ochrobactrum anthropi, O. intermedium) are structured in order to precise their transmission and their infectivity in the general context of impaired ecological niche and pathobiome.The results obtained at various microbiological scale (community, population, species, phylotype) are organized in this general context in order to delineate an original integrative vision of HAI
Pauvert, Charlie. "Comparaison et évaluation d’approches bioinformatiques et statistiques pour l'analyse du pathobiome des plantes cultivées." Thesis, Bordeaux, 2019. http://www.theses.fr/2019BORD0214/document.
Interactions between microorganisms underpin many ecosystem services, including the regulation of crop diseases. An actor in this regulation is the pathobiome, defined as the subset of microorganisms associated with a host plant in interaction with a pathogen. One of the current challenges is to reconstruct pathobiomes from metabarcoding data, in order to identify potential biocontrol agents and to monitor in real time their responses to environmental changes. However, several methodological hurdles must be overcomed to achieve these objectives. First, there is no consensus on the most reliable bioinformatics approach to determine the identity and abundance of microorganisms present in plant samples. In addition, microbial networks built with currently available methods are networks of statistical associations between sequence counts, not directly related to networks of interactions (e. g. competition, parasitism) between microorganisms. The objective of the thesis was therefore to determine the most relevant bioinformatics and statistical approaches to reconstruct microbial interaction networks from metabarcoding data. The study system was grapevine (Vitis vinifera L. cv. Merlot noir) and the fungal agent of grapevine powdery mildew Erysiphe necator. First, we determined the most appropriate bioinformatics approach to identify the fungal community associated with this pathogen, by comparing the ability of 360 pipelines to recover the composition of an artificial community of 189 fungal strains. DADA2 has emerged as the most powerful tool. We then evaluated the influence of the cropping system (conventional vs. organic viticulture) on foliar fungal communities and assessed the level of replicability of microbial networks built with a standard inference method, SparCC. Replicability was very low, casting doubt on the usefulness of these networks for biocontrol and biomonitoring We therefore used a new statistical approach, the PLN model, which allows us to take into account environmental variability, to finely explore the pathobiome of Erysiphe necator. The microbial interactions predicted by the model are being compared with experiments confronting yeasts in co-cultures. An alternative approach, HMSC, was also tested on another biological model and some predictions were successfully compared with the data in the literature. Microbial networks, provided improved reconstruction methods, could therefore be used to capture signals of biotic interactions in the pathobiome
Tröger, Hanno [Verfasser]. "Wirkungsweise von Pathogenen, Pathobionten und Probiotika auf die epitheliale Transport- und Barrierefunktion des Darms / Hanno Tröger." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2017. http://d-nb.info/1123071632/34.
Chow, Janet. "A Pathobiont of the Mammalian Microbiota Balances Intestinal Inflammation and Colonization." Thesis, 2011. https://thesis.library.caltech.edu/6368/1/Chow%2C_Janet_Thesis.pdf.
Книги з теми "Pathobiont":
Spatz, Linda Ann, Judith A. James, and Gregg Joshua Silverman, eds. Pathogens, Pathobionts and Autoimmunity. Frontiers Media SA, 2021. http://dx.doi.org/10.3389/978-2-88971-546-6.
Частини книг з теми "Pathobiont":
Dimkić, Ivica, Aleksandra Jelušić, Katarina Kruščić, and Tamara Janakiev. "Pathobiome and Microbial Community Shifts Associated with Vegetable, Fruit, and Cereal Crops." In Plant Pathogen Interaction, 237–58. Singapore: Springer Nature Singapore, 2023. http://dx.doi.org/10.1007/978-981-99-4890-1_9.
Bez, Cristina, Hang Dinh Thuy, Minh Nguyen Hong, Iris Bertani, and Vittorio Venturi. "Pathobiome Studies as a Way to Identify Microbial Co-operators and/or Antagonists of the Incoming Plant Pathogen." In Innovations in Land, Water and Energy for Vietnam’s Sustainable Development, 53–65. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-51260-6_6.
Stewart, Jane E., Mee-Sook Kim, Bradley Lalande, and Ned B. Klopfenstein. "Pathobiome and microbial communities associated with forest tree root diseases." In Forest Microbiology, 277–92. Elsevier, 2021. http://dx.doi.org/10.1016/b978-0-12-822542-4.00004-8.
Bateman, Kelly S., Stephen W. Feist, John P. Bignell, David Bass, and Grant D. Stentiford. "Marine pathogen diversity and disease outcomes." In Marine Disease Ecology, 3–44. Oxford University Press, 2020. http://dx.doi.org/10.1093/oso/9780198821632.003.0001.
Coates, Christopher J. "Diseases of chelicerates." In Invertebrate Pathology, 219–48. Oxford University Press, 2022. http://dx.doi.org/10.1093/oso/9780198853756.003.0009.
Тези доповідей конференцій з теми "Pathobiont":
Azzouz, Doua F., Jill P. Buyon, and Gregg J. Silverman. "AI-26 Intestinal IGA as pathfinders to identify microbiome pathobiont candidates in SLE." In Abstracts of the Third Biannual Scientific Meeting of the North and South American Lupus Community, Armonk, New York, USA, September 29 – October 1, 2016. Lupus Foundation of America, 2016. http://dx.doi.org/10.1136/lupus-2016-000179.26.
Silverman, Gregg J., Macintosh Cornwell, Peter Izmirly, Jill Buyon, Doua F. Azzouz, and Kelly Ruggles. "1103 Lupus clinical flares in patients with gut pathobiont blooms share a novel peripheral blood transcriptomic immune activation profile." In LUPUS 21ST CENTURY 2022 CONFERENCE, Abstracts of Sixth Scientific Meeting of North American and European Lupus Community, Tucson, AZ, USA – September 20–23, 2022. Lupus Foundation of America, 2022. http://dx.doi.org/10.1136/lupus-2022-lupus21century.68.
Pereira, M. S., K. Stuhlträger, N. Effelsberg, A. Rajput Khokhar, S. Redanz, H. Ebid, B. Hansen, et al. "OP0047 FASTING MODULATES THE HUMAN GUT MICROBIOME AND REDUCES AN IL-17+/IFNG+ T CELL-INDUCING GUT PATHOBIONT IN PATIENTS WITH RHEUMATOID ARTHRITIS." In EULAR 2024 European Congress of Rheumatology, 12-15 June. Vienna, Austria. BMJ Publishing Group Ltd and European League Against Rheumatism, 2024. http://dx.doi.org/10.1136/annrheumdis-2024-eular.3302.
Khomyakova, T. I., and Yu N. Khomyakov. "PATHOBIOM: STAGES OF FORMATION AND WAYS OF MANAGEMENT." In INNOVATIVE TECHNOLOGIES IN SCIENCE AND EDUCATION. DSTU-Print, 2020. http://dx.doi.org/10.23947/itno.2020.306-310.
Li, L., M. Mac Aogáin, T. Xu, T. Jaggi, L. L Y Chan, J. Qu, L. Wei, et al. "Neisseria species as pathobionts in bronchiectasis." In ERS International Congress 2022 abstracts. European Respiratory Society, 2022. http://dx.doi.org/10.1183/13993003.congress-2022.1566.
Jaggi, T., M. Mac Aogáin, H. R. Keir, A. Dicker, T. Xu, M. S. Koh, T. H. Ong, et al. "Neisseria Species as Novel Respiratory Pathobionts in Bronchiectasis." In American Thoracic Society 2021 International Conference, May 14-19, 2021 - San Diego, CA. American Thoracic Society, 2021. http://dx.doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a3903.
Aogáin, Micheál Mac, Li Liang, Tengfei Xu, Tavleen Jaggi, Louisa L. Y. Chan, Holly R. Keir, Alison J. Dicker, et al. "Characterizing Neisseria spp. as novel respiratory pathobionts in bronchiectasis." In ERS International Congress 2021 abstracts. European Respiratory Society, 2021. http://dx.doi.org/10.1183/13993003.congress-2021.pa2060.
Fernandez-Barat, L., R. López-Aladid, V. Alcaraz, N. Vázquez, L. Bueno, R. Pastor, L. Lingren, et al. "The Mucoid Pathobiome and Its Clinical Implications in Non-Cystic Fibrosis Bronchiectasis." In American Thoracic Society 2022 International Conference, May 13-18, 2022 - San Francisco, CA. American Thoracic Society, 2022. http://dx.doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a2001.
"Actinidia host genetic background dictates oomycete pattern in the Kiwifruit Vine Decline Syndrome pathobiome." In IS-MPMI Congress. IS-MPMI, 2023. http://dx.doi.org/10.1094/ismpmi-2023-12.