Дисертації з теми "Papillomaviruses"
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Jolly, Carol Elizabeth. "The effects of leptomycin B on HPV-infected cells /." St Andrews, 2008. http://hdl.handle.net/10023/900.
Повний текст джерелаTidy, John Anthony. "Human papillomaviruses and cervical neoplasia." Thesis, Imperial College London, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.267104.
Повний текст джерелаMatsha, Tandi Edith. "Human Papillomaviruses in oesophageal cancer." Doctoral thesis, University of Cape Town, 2003. http://hdl.handle.net/11427/3140.
Повний текст джерелаFothergill, Thomas. "Receptor signalling and internalisation of papillomaviruses /." [St. Lucia, Qld.], 2006. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe19808.pdf.
Повний текст джерелаBrestovac, Brian. "Human papillomavirus and cervical cancer in Western Australia." University of Western Australia. School of Biomedical and Chemical Sciences, 2005. http://theses.library.uwa.edu.au/adt-WU2006.0037.
Повний текст джерелаSmith, Lisa G. "HPV knowledge of college females and their intention to receive the HPV vaccination." Virtual Press, 2008. http://liblink.bsu.edu/uhtbin/catkey/1399190.
Повний текст джерелаDepartment of Physiology and Health Science
Wong, Weng-man Valerie. "Prevalence, genotypes and risk factors of human papillomavirus infection among women in Macao a cross-sectional study /." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B42998013.
Повний текст джерелаCheung, Yim-hing. "Rare types and polymorphic variants of HPV in Hong Kong." Hong Kong : University of Hong Kong, 2002. http://sunzi.lib.hku.hk/hkuto/record.jsp?B25176559.
Повний текст джерелаPakarian, Farzin Bouzorgmehr. "Perinatal transmission and persistence of human papillomaviruses." Thesis, University of Leicester, 1998. http://hdl.handle.net/2381/29553.
Повний текст джерелаShah, S. D. "Understanding the evolutionary history of the papillomaviruses." Thesis, University College London (University of London), 2012. http://discovery.ucl.ac.uk/1366951/.
Повний текст джерелаGu, Zhengming. "Studies on molecular mechanisms of transformation by human papillomavirus : the role of E6 and E5 oncogenes." Thesis, McGill University, 1996. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=40133.
Повний текст джерелаJolly, Carol E. "The effects of leptomycin B on HPV-infected cells." Thesis, University of St Andrews, 2008. http://hdl.handle.net/10023/900.
Повний текст джерелаStrauss, Susanne. "Studies on the molecular epidemiology of human papillomaviruses." Thesis, Open University, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.437780.
Повний текст джерелаVerstraten, Ruth. "Innate immune evasion strategies of persistent human papillomavirus 16." Thesis, University of Cambridge, 2014. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708295.
Повний текст джерелаBarker, Emily Mary. "Virus-host interactions in the innate immune response to high-risk human papillomavirus." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610618.
Повний текст джерелаGiannoudis, Athina. "Human papillomaviruses in squamous intraepithelial lesions of the cervix." Thesis, University of Liverpool, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.250230.
Повний текст джерелаKaye, Jeremy Neil. "Vertical transmission and persistence of cancer-associated human papillomaviruses." Thesis, King's College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.392521.
Повний текст джерелаLanham, Stuart Andrew. "Molecular biology of papillomaviruses in pre-malignant cervical infection." Thesis, University of Southampton, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.323803.
Повний текст джерелаTomlins, Christine Helen. "Induction of anti-apoptotic factors by cutaneous Human Papillomaviruses." Thesis, University of Oxford, 2010. http://ora.ox.ac.uk/objects/uuid:121b0494-9cca-4fee-a800-b54fc36fe43e.
Повний текст джерелаLyman, Rachel C. "Cell cycle control and its modulation in HPV infected cells /." St Andrews, 2009. http://hdl.handle.net/10023/863.
Повний текст джерелаTsang, Chi-kit Percy. "HPV genotyping and integration in cervical cancer and precursor lesions /." View the Table of Contents & Abstract, 2005. http://sunzi.lib.hku.hk/hkuto/record/B3149416X.
Повний текст джерелаSze, S. M. Candy. "Evaluation and comparison of molecular diagnostic methods for detection of human papillomavirus (HPV) in relation to cervical neoplasia /." View the Table of Contents & Abstract, 2006. http://sunzi.lib.hku.hk/hkuto/record/B37552752.
Повний текст джерелаStewart, Deborah. "P53 regulatory mechanisms by human papillomavirus (HPV) E6 and alternative splicing." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=85651.
Повний текст джерелаIn this study, we characterized two important regulatory mechanims of p53 activity: (i) Human papillomavirus (HPV) E6 interaction and (ii) alternative splicing. Recognized as the major etiological agents for cervical cancer, the oncogenic potential of HPVs correlates with their ability to target p53 for degradation. This study demonstrates that both p53 and HPV-18 E6 are exported from the nucleus when co-expressed, via a process that involves the C-terminal nuclear export signal (NES) of p53. However, neither nuclear export nor the p53 C-terminal NES is required for HPV-18 E6-mediated ubiquitination or degradation of p53.
This study also demonstrates that both low- and high-risk HPV E6 proteins are degraded by the ubiquitin-proteasome pathway, and thus provides an explanation for the low levels of E6 detected in cervical cancer cells.
Also reported in this study is a novel mechanism of p53 regulation arising through alternative splicing. This novel mRNA encodes a N-terminal deleted isoform of p53, termed p47. As demonstrated within, p47 does not supress cell viability but impairs both p53-mediated transcriptional activity and growth suppression. Interestingly, p47 increases both p53 monoubiquitination and nuclear export. We propose that p47 induces nuclear export of p53 by a mechanism involving monoubiquitination, as supported by recent findings from Li and colleagues (2003). The p47 protein also protects p53 from both Mdm2- and HPV-18 E6-mediated degradation. A number of cancers display abnormal localization of wildtype p53, and it will be important to examine the role of p47 in these tumours.
Taken together, the regulation of p53 activity by both HPV E6 and the alternative splice variant p47 involves alterations in p53 ubiquitination status, protein stability, and cell localization. Insight gained into these negative regulatory mechanisms may aid in the design of therapeutic strategies for reactivating wild-type p53 in HPV-associated and non-associated cancers.
Lam, Wai-hung, and 林偉雄. "The current situation of human papillomavirus (HPV) associated oropharyngeal cancer : a multi-institutional cohort study in Hong Kong." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/206586.
Повний текст джерелаpublished_or_final_version
Surgery
Master
Master of Medical Sciences
Al-ayadhy, Bushra Y. "The effect of CD21 on proliferation and differentiation on human cervical epithelium." Thesis, University of Aberdeen, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.388944.
Повний текст джерелаCondjella, Rachel. "Unique properties of the canine papillomavirus type II E5 protein." Connect to Electronic Thesis (ProQuest) Connect to Electronic Thesis (CONTENTdm), 2009. http://worldcat.org/oclc/457185147/viewonline.
Повний текст джерелаGraham, Andrew Keith. "Human papillomaviruses and cervical neoplasia : detection, prevalence and prognostic significance." Thesis, University of Hertfordshire, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.387195.
Повний текст джерелаArends, Mark J. "Regulation of tumour growth and apoptosis by oncogenes and papillomaviruses." Thesis, University of Edinburgh, 1992. http://hdl.handle.net/1842/19771.
Повний текст джерела張艷馨 and Yim-hing Cheung. "Rare types and polymorphic variants of HPV in Hong Kong." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2002. http://hub.hku.hk/bib/B31970448.
Повний текст джерелаYan, Chun-kit, and 甄俊傑. "Prevalence and pattern of human papillomavirus infection in females, with cytology correlation: the Hong Kongexperience." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B48421492.
Повний текст джерелаpublished_or_final_version
Medical Sciences
Master
Master of Medical Sciences
Perrons, Christopher John. "Papovaviruses in humans." Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368850.
Повний текст джерелаParish, Joanna L. "The induction of apoptosis by the human papillomavirus type 16 E2 protein." Thesis, University of Bristol, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.391157.
Повний текст джерелаHe, Dan. "Clinical and pathological significance of HPV infection and p53 mutation in human esophageal cancer /." Hong Kong : University of Hong Kong, 1997. http://sunzi.lib.hku.hk/hkuto/record.jsp?B1961620X.
Повний текст джерелаGiacomini, Rosane. "Expressão imunohistoquímica de biomarcadores e sua relação com o Papiloma vírus humano em carcinomas de cabeça e pescoço." reponame:Repositório Institucional da UCS, 2017. https://repositorio.ucs.br/handle/11338/3665.
Повний текст джерелаCoordenação de Aperfeiçoamento de Pessoal de Nível Superior, CAPES
Head and neck cancer is considered the sixth most prevalent neoplasm in the world, with more than six hundred thousand new cases diagnosed each year and the fifth most prevalent in Brazil, with more than one thousand five hundred people affected annually, being responsible, worldwide, by four percent of cancer mortality. The most common type is squamous cell carcinoma (CECP), its pathogenesis has been historically associated with tobacco and alcohol use, but in the last decades HPV infection has been associated with the disease. Defining the prognosis and risk of development, as well as the success of the treatment in response to a particular medication and/ or procedure, are the main reason for the identification of biomarkers, and their expression may reflect several processes in progress in tumor cells. Several studies have correlated the expression of survivin in solid tumors with a clinically unfavorable course of the disease, drug resistance, worse prognosis and shorter patient survival. p16 may provide evidence of the malignant potential of an injury, and its overexpression may be considered a favorable prognostic marker. Elevated PD-L1 expression may be an important facilitator for tumor growth and metastasis. The objective of this work was to identify, by immunohistochemistry, the levels of expression of p16, survivin and PD-L1 in samples of head and neck malignant lesions in the presence and absence of HPV viral infection and to relate them to the clinical findings of patients. Thirty-three tissue samples were used, obtained by biopsy of head and neck lesions, for diagnostic purposes, coming from the Oncology Service of the General Hospital of Caxias do Sul and from the Diagnose Laboratory database. Samples were retrospectively selected, having as selection criterion the presence of squamous cell carcinoma of the head and neck. The determination of the presence of HPV and viral typing was performed by the polymerase chain reaction method and the protein expression by immunohistochemistry. The results were evaluated considering the proportion of positive cells compared to the total number of cells in the field. The overexpression of p16 in CECPs may be indicative of the participation of HPV infection during the carcinogenesis process, being that the relationship between p16 overexpression and the presence of HPV infection was not observed in some of the evaluated cases, which may indicate: failure in the PCR achievement, not detecting the presence of HPV; the non-participation of HPV in the process of carcinogenesis; the synergism between the carcinogenic pathways HPV+ and HPV- (smoking/alcoholism). In addition, the overexpression of p16 in conjunction with the expression of survivin and/or PD-L1 indicates an intermediate behavior, between cancers HPV+ and HPV- (pathway carcinogenic smoking/alcoholism). p16, survivin and PD-L1 are indicative of the carcinogenic pathway HPV+, and may predict if there was synergism between carcinogenic pathways as well as indicate the behavior of tumors, however should not be used in isolation, including PCR for HPV. The biomarkers evaluated in this study may be useful in the clinical management of patients, besides helping in the development of new therapeutic modalities, being necessary to obtain a greater number of cases and information on the expression of these biomarkers.
Kan, Chin-Yi. "Human Papillomavirus in human breast cancer and cellular immortalisation." Sydney : University of New South Wales. Biotechnology and Biomolecular Sciences, 2007. http://www.library.unsw.edu.au/~thesis/adt-NUN/public/adt-NUN20071004.080541/.
Повний текст джерелаGreen, Jonathan. "The role of semen in the transmission of genital human papillomaviruses." Thesis, University of Surrey, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.334308.
Повний текст джерелаKell, Barbara. "Studies on the E5 and E7 proteins of genital human papillomaviruses." Thesis, King's College London (University of London), 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266401.
Повний текст джерелаForslund, Ola. "Genital human papillomaviruses studies of their occurrence, type spectrum and expression /." Malmö : Dept. of Medical Microbiology, Section of Virology, Lund University, University Hospital, 1997. http://catalog.hathitrust.org/api/volumes/oclc/44966987.html.
Повний текст джерелаCesur, Ozlem. "Using RNA aptamers to manipulate the functions of human papillomaviruses (HPV)." Thesis, University of Leeds, 2015. http://etheses.whiterose.ac.uk/9312/.
Повний текст джерелаSavini, Federica <1985>. "Host Jump in BPVs: is Species- Specificity Still Appropriate for Papillomaviruses?" Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2016. http://amsdottorato.unibo.it/7639/2/Tesi_dottorato_Savini_31.3.16.pdf.
Повний текст джерелаSavini, Federica <1985>. "Host Jump in BPVs: is Species- Specificity Still Appropriate for Papillomaviruses?" Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2016. http://amsdottorato.unibo.it/7639/.
Повний текст джерелаHerrington, Charles Simon. "In situ analysis of human papillomaviruses and chromosome aberrations in cervical neoplasia." Thesis, University of Oxford, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.279806.
Повний текст джерелаMackintosh, Lorna J. "The role of Human Papillomaviruses and their replication in nonmelanoma skin cancer." Thesis, University of Glasgow, 2012. http://theses.gla.ac.uk/3388/.
Повний текст джерелаAgaba, Charles Ateenyi. "Human papillomaviruses and their association with squamous cell carcinoma of the conjunctiva." Stockholm : Kampala : Karolinska Institutet ; Makerere University, 2009. http://diss.kib.ki.se/2009/978-91-7409-599-9/.
Повний текст джерелаKwan, Tak-ching Tracy, and 關德貞. "Human papillomavirus testing in cervical cancer screening: potential harms and implications for intervention." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B4658836X.
Повний текст джерелаLeung, Tsin-wah, and 梁展華. "The role of human papillomavirus (HPV)-related molecular markers in cervical neoplasia, with emphasis on p-21 activated kinase type 1 (PAK 1)." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/195983.
Повний текст джерелаpublished_or_final_version
Obstetrics and Gynaecology
Doctoral
Doctor of Philosophy
Ashby, Andrew Daniel Mark. "An investigation into the effects of the E5 family of transforming proteins on the vacuolar proton-translocating ATPase." Thesis, University of Glasgow, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.341724.
Повний текст джерелаScobie, Linda. "The role of p53 in cell transformation by BPV-4." Thesis, University of Glasgow, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.360279.
Повний текст джерелаMota, Fernando Luis da Cruz Fernandes. "The immune microenvironment in HPV-related cervical neoplasia." Thesis, University College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.287582.
Повний текст джерелаDaniels, Paula Rosamund. "Characterisation of HPV type 16 E6 interactions with p53 and E6-associated protein in vitro and ex vivo." Thesis, University of York, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.387558.
Повний текст джерела