Готові списки джерел за темами / PAMPs and DAMP

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Добірка наукової літератури з теми "PAMPs and DAMP"

Автор: Grafiati

Опубліковано: 10 березня 2023

Оновлено: 31 липня 2025

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Статті в журналах з теми "PAMPs and DAMP"

Chen, Jiann Chu. "The complex of damage-associated molecular pattern and its inducer, pathogen-associated molecular pattern enhance triggering innate immunity in shrimp (VET1P.1128)." Journal of Immunology 194, no. 1_Supplement (2015): 146.16. http://dx.doi.org/10.4049/jimmunol.194.supp.146.16.

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Abstract Peptidoglycan (PG) derived commonly from Gram-positive bacteria, is one of pathogen-associated molecular pattern (PAMP). Incubating hemocytes of shrimp in PG caused degranulation, changes in cell size, reduction in the percentage of cell viability, necrosis of hemocytes, and released intracellular molecules containing damage-associated molecular pattern (DAMP) that is well known in mammals and teleosts. Incubating shrimp hemocytes in PAMP, DAMP or the mixture of PAMPs plus DAMPs all induced significant increases in phenoloxidase (PO) activity and respiratory burst (RB, release of supe

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Andersson, Ulf, Kevin J. Tracey, and Huan Yang. "Post-Translational Modification of HMGB1 Disulfide Bonds in Stimulating and Inhibiting Inflammation." Cells 10, no. 12 (2021): 3323. http://dx.doi.org/10.3390/cells10123323.

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High mobility group box 1 protein (HMGB1), a highly conserved nuclear DNA-binding protein, is a “damage-associated molecular pattern” molecule (DAMP) implicated in both stimulating and inhibiting innate immunity. As reviewed here, HMGB1 is an oxidation-reduction sensitive DAMP bearing three cysteines, and the post-translational modification of these residues establishes its proinflammatory and anti-inflammatory activities by binding to different extracellular cell surface receptors. The redox-sensitive signaling mechanisms of HMGB1 also occupy an important niche in innate immunity because HMGB

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Jang, Gun-Young, Ji won Lee, Young Seob Kim, et al. "Interactions between tumor-derived proteins and Toll-like receptors." Experimental & Molecular Medicine 52, no. 12 (2020): 1926–35. http://dx.doi.org/10.1038/s12276-020-00540-4.

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AbstractDamage-associated molecular patterns (DAMPs) are danger signals (or alarmins) alerting immune cells through pattern recognition receptors (PRRs) to begin defense activity. Moreover, DAMPs are host biomolecules that can initiate a noninflammatory response to infection, and pathogen-associated molecular pattern (PAMPs) perpetuate the inflammatory response to infection. Many DAMPs are proteins that have defined intracellular functions and are released from dying cells after tissue injury or chemo-/radiotherapy. In the tumor microenvironment, DAMPs can be ligands for Toll-like receptors (T

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Zanoni, Ivan, and Marco Di Gioia. "Endogenous oxidized phospholipids reprogram cellular metabolism and boost hyperinflammation." Journal of Immunology 204, no. 1_Supplement (2020): 69.1. http://dx.doi.org/10.4049/jimmunol.204.supp.69.1.

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Abstract Pathogen-associated molecular patterns (PAMPs) have the capacity to couple inflammatory gene expression to changes in macrophage metabolism, both of which influence subsequent inflammatory activities. Similar to their microbial counterparts, several self-encoded damage-associated molecular patterns (DAMPs) induce inflammatory gene expression. However, whether this symmetry in host responses between PAMPs and DAMPs extends to metabolic shifts is unclear. Here we report that the self-encoded oxidized phospholipid oxPAPC alters the metabolism of macrophages exposed to lipopolysaccharide

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Fowler, Teresa E., Vivek Choudhary, Samuel Melnyk, et al. "Dioleoylphosphatidylglycerol Inhibits Heat Shock Protein B4 (HSPB4)-Induced Inflammatory Pathways In Vitro." International Journal of Molecular Sciences 24, no. 6 (2023): 5839. http://dx.doi.org/10.3390/ijms24065839.

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Our previous work shows that dioleoylphosphatidylglycerol (DOPG) accelerates corneal epithelial healing in vitro and in vivo by unknown mechanisms. Prior data demonstrate that DOPG inhibits toll-like receptor (TLR) activation and inflammation induced by microbial components (pathogen-associated molecular patterns, PAMPs) and by endogenous molecules upregulated in psoriatic skin, which act as danger-associated molecular patterns (DAMPs) to activate TLRs and promote inflammation. In the injured cornea, sterile inflammation can result from the release of the DAMP molecule, heat shock protein B4 (

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Jiménez-Hernández, Alejandra, Ireri Alejandra Carbajal-Valenzuela, Irineo Torres-Pacheco, et al. "Extracellular DNA as a Strategy to Manage Vascular Wilt Caused by Fusarium oxysporum in Tomato (Solanum lycopersicum L.) Based on Its Action as a Damage-Associated Molecular Pattern (DAMP) or Pathogen-Associated Molecular Pattern (PAMP)." Plants 13, no. 21 (2024): 2999. http://dx.doi.org/10.3390/plants13212999.

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Vascular wilt is an important tomato disease that affects culture yields worldwide, with Fusarium oxysporum (F.o) being the causal agent of this infection. Several management strategies have lost effectiveness due to the ability of this pathogen to persist in soil and its progress in vascular tissues. However, nowadays, research has focused on understanding the plant defense mechanisms to cope with plant diseases. One recent and promising approach is the use of extracellular DNA (eDNA) based on the ability of plants to detect their self-eDNA as damage-associated molecular patterns (DAMPs) and

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Idrus, Hasta Handayani, Mochammad Hatta, Vivien Novarina Kasim, et al. "Molecular Impact on High Motility Group Box-1 (HMGB-1) in Pamps and Damp." Indian Journal of Public Health Research & Development 10, no. 8 (2019): 1109. http://dx.doi.org/10.5958/0976-5506.2019.02045.x.

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Shamilov, Rambon, Tyler W. Ackley, and Brian J. Aneskievich. "Enhanced Wound Healing- and Inflammasome-Associated Gene Expression in TNFAIP3-Interacting Protein 1- (TNIP1-) Deficient HaCaT Keratinocytes Parallels Reduced Reepithelialization." Mediators of Inflammation 2020 (April 21, 2020): 1–14. http://dx.doi.org/10.1155/2020/5919150.

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TNIP1 protein is a widely expressed, cytoplasmic inhibitor of inflammatory signaling initiated by membrane receptors such as TLRs which recognize pathogen-associated and damage-associated molecular patterns (PAMPs and DAMPs). Keratinocyte TNIP1 deficiency sensitizes cells to PAMPs and DAMPs promoting hyperresponsive expression and secretion of cytokine markers (e.g., IL-8 and IL-6) relevant to cases of chronic inflammation, like psoriasis, where TNIP1 deficiency has been reported. Here, we examined the impact of TNIP1 deficiency on gene expression and cellular responses (migration and viabilit

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Negishi, Hideo, Nobuyasu Endo, Yuki Nakajima, et al. "Identification of U11snRNA as an endogenous agonist of TLR7-mediated immune pathogenesis." Proceedings of the National Academy of Sciences 116, no. 47 (2019): 23653–61. http://dx.doi.org/10.1073/pnas.1915326116.

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The activation of innate immune receptors by pathogen-associated molecular patterns (PAMPs) is central to host defense against infections. On the other hand, these receptors are also activated by immunogenic damage-associated molecular patterns (DAMPs), typically released from dying cells, and the activation can evoke chronic inflammatory or autoimmune disorders. One of the best known receptors involved in the immune pathogenesis is Toll-like receptor 7 (TLR7), which recognizes RNA with single-stranded structure. However, the causative DAMP RNA(s) in the pathogenesis has yet to be identified.

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Dwyer, Gaelen K., Lisa Mathews, Anna Lucas, et al. "IL-33 upregulated in fibroblastic reticular cells after recipient conditioning acts as a novel costimulatory signal in the generation of alloreactive Type 1 T helper cells." Journal of Immunology 208, no. 1_Supplement (2022): 175.08. http://dx.doi.org/10.4049/jimmunol.208.supp.175.08.

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Abstract In allogeneic hematopoietic stem cell transplantation (alloHCT), recipient conditioning releases Pathogen- and Damage-Associated Molecular Patterns (PAMPs and DAMPs) that generate pro-inflammatory antigen-presenting cells (APC) that secrete IL-12 to initiate donor Type 1 T helper (Th1) responses causing graft-vs-host-disease (GVHD). Yet, other mechanisms exist to initiate alloimmune responses, as recipients with disrupted APC PAMP/DAMP signaling or lacking IL-12 develop GVHD. We used IL-33 receptor, ST2, deficient B6 mice as T cell donors into BALB/c recipients to test the hypothesis

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Більше джерел

Дисертації з теми "PAMPs and DAMP"

ARTUSO, IRENE. "DAMPs and PAMPs have distinct roles in neutrophil recruitment during cutaneous microbial infections." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2021. http://hdl.handle.net/10281/304783.

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Intradermal infections with C. albicans are eliminated by neutrophils recruited at the site of infection with an unknown mechanism. To dissect how neutrophils are recruited at the site of infection, we analyzed the involvement of PRR that recognize C. albicans (TLR4, TLR2, Dectin1 and Dectin2) as well as CARD9, activated downstream Dectins, and MyD88 that transduces the signal derived from TLRs. WT, PRR-deficient and CARD9-deficient mice did not show any defect in neutrophil recruitment after C. albicans intradermal injection. Diversely, MyD88-deficient mice do not recruit neutrophils after C.

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Nativel, Brice. "Pathologie inflammatoire : étude de la contribution des PAMP et DAMP." Thesis, La Réunion, 2017. http://www.theses.fr/2017LARE0065.

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L’inflammation est le mécanisme de base du système immunitaire. Dans le cas de pathologie inflammatoire cette inflammation persiste et devient délétère pour l’organisme. Les causes de cette persistance peuvent être variées. L’une de ces causes est la présence de molécules induisant l’inflammation. Elles peuvent être d’origine exogène comme les PAMP (Pathogen-Associated Molecular Pattern). Ce sont des molécules issues des pathogènes (LPS, peptidoglycanes, ADN CpG) capables d’activer le système immunitaire. Ces molécules peuvent également être d’origine endogène comme les DAMP (Damage Associated

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Eliasse, Yoan. "L’acné : une mésentente entre P.acnes et le système immunitaire ?" Thesis, Toulouse 3, 2019. http://www.theses.fr/2019TOU30081.

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L’acné vulgaris est une maladie inflammatoire chronique affectant l’unité pilosébacée. Elle démarre le plus souvent à l’adolescence et résulte en des lésions pouvant être inflammatoires (papules, nodules) ou non inflammatoires (comédons ouverts ou fermés). Cette pathologie a fait l’objet de nombreuses études et quatre facteurs majeurs ont été décrits : une hyperkératinisation, un excès de la production de sébum, la mise en place d’une réponse inflammatoire et la colonisation du follicule pileux par la bactérie Propionibacterium acnes. Ce dernier point est l’un des plus débattu et le rôle de ce

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Pizzuto, Malvina. "Unravelling the Promiscuity of Toll-like Receptor 2 and 4: New Non-Microbial Immune-Modulators and Their Mode of Recognition by TLRs." Doctoral thesis, Universite Libre de Bruxelles, 2017. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/258030.

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[French below]TLRs are the sentinels of our cells, they are located at the cell surface and alert the whole immune system of the presence of viruses or bacteria. They detect pathogens by recognizing their molecular patterns; this recognition is specific in order to avoid self-recognition, but they need some degree of promiscuity to remedy to pathogen heterogeneity or mutations. Promiscuity is generally defined as an indiscriminate association with molecules regardless their structure and is the contrary of specificity proper of the classic paradigm of key-lock receptor activation. My thesis re

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Chumble, Anuja. "Epigenetic Alterations of Toll-Like Receptors by TET2 in Spontaneous Preterm Labor." VCU Scholars Compass, 2014. http://scholarscompass.vcu.edu/etd/3469.

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Increasing evidence implicates the presence of bacteria in intrauterine tissues as an important risk factor for spontaneous preterm labor. Epigenetic alterations of innate immunity genes may increase the mother’s sensitivity to subclinical levels of bacteria. This study examined the presence of TET2, TLR-2, and TLR-9 in intrauterine tissue, and evaluated whether epigenetic alterations of these genes, as well as IL-8, changed their expression in human decidual tissue and a macrophage cell culture. Immunohistochemicalstaining was used to detect the presence of these proteins in intrauterine tiss

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MARTI, LUCIA. "In vivo studies to characterize a protein involved in Golgi apparatus-mediated trafficking and a mitogen-activated protein kinase kinase kinase family (ANPs) involved in plant immunity." Doctoral thesis, 2013. http://hdl.handle.net/2158/804096.

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Utilizzando Arabidopsis thaliana come organismo modello ho effettuato studi in vivo per capire quali sono i meccanismi che controllano l'integrita' dell'apparato del Golgi in una prima parte della tesi di dottorato. In una seconda parte ho effettuato degli studi per capire gli eventi di dinamica subcellulare che intervengono nell'immunita' innata delle piante mediati da PAMP (Pathogen-Associated Molecular Patterns) e DAMP (Damage -Associated Molecular Patterns).

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Janova, Hana. "Organization and consequences of functional responses in microglia upon activation of the TLR4 complex." Doctoral thesis, 2014. http://hdl.handle.net/11858/00-1735-0000-0023-98EB-3.

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Mikroglia sind residente Makrophagen-artige Zellen des Zentralnervensystems (ZNS), die das Gewebe kontinuierlich auf Anzeichen homöostatischer Störungen überwachen. Als die wesentlichen immunkompetenten Effektorzellen im Hirnparenchym exprimieren sie eine Vielzahl von Rezeptoren für pathogen-assoziierte molekulare Strukturmuster (pathogen-associated molecular patterns, PAMPs). Zu diesen Rezeptoren zählt der Toll-like receptor (TLR) 4, der nicht nur Reaktionen der Mikroglia auf bakterielle Infektionen, sondern auch auf Gewebe Schädigungen ermöglicht. Stimulation des TLR4 mit bakteriellem Lipopo

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Scheffel, Jörg. "Plasma Factors as Endogenous Agonists and Modulators of TLR4 Signaling in Microglia." Doctoral thesis, 2010. http://hdl.handle.net/11858/00-1735-0000-0006-B515-C.

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Duval, Cyntia. "Étude de l’inflammation placentaire lors de complications de la grossesse." Thesis, 2020. http://hdl.handle.net/1866/24852.

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Le placenta est l’organe central de la grossesse et son bon fonctionnement est essentiel pour mener à une grossesse à terme sans complication. L’inflammation joue un rôle très important dans les différentes étapes de la grossesse, de l’implantation à l’accouchement. Lorsque cette inflammation est débalancée au niveau du placenta, cela peut causer plusieurs altérations de ses fonctions. L’inflammation peut être induite par deux différents stimuli, soient par une intervention externe, donc infectieux (via les Pathogen-Associated Molecular Patterns, PAMPs) ou de façon endogène (via les Damage-Ass

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Книги з теми "PAMPs and DAMP"

Wiersinga, W. Joost, and Tom van der Poll. The host response to infection in the critically ill. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0303.

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Infection continues to be a leading cause of intensive care unit death. The host response to infection can be seen as a pattern recognition receptor (PRR)-mediated dysregulation of the immune system following pathogen invasion in which a careful balance between inflammatory and anti-inflammatory responses is vital. A measured and rapid response to microbial invasion is essential to health. The same immunological and coagulation systems that protect against localized infection can act to our disadvantage when these systems are activated systemically during generalized microbial infection. Toll-

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Частини книг з теми "PAMPs and DAMP"

Land, Walter Gottlieb. "Prologue: About DAMPs, PAMPs, and MAMPs." In Damage-Associated Molecular Patterns in Human Diseases. Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-78655-1_11.

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Willart, Monique A. M., Philippe Poulliot, Bart N. Lambrecht, and Mirjam Kool. "PAMPs and DAMPs in Allergy Exacerbation Models." In Methods in Molecular Biology. Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-496-8_15.

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Krishnan, Jayalakshmi. "Pattern Recognition Receptors in Brain: Emphasis on Toll Like Receptors and their Types." In Toll-Like Receptors in Vector-borne Diseases. BENTHAM SCIENCE PUBLISHERS, 2023. http://dx.doi.org/10.2174/9789815124545123010004.

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The immune system is highly complex; it senses foreign invaders, thus protecting the body. The adaptive arm of the immune system confers long-term protection, whereas the innate immune system confers immediate protection. In the case of the immune system, the pattern recognition receptors offer various modes of sensing the pathogen-associated molecular patterns present in pathogens. The receptors that sense invading pathogens are called Pattern recognition receptors [1]. The adaptive immune system is very sophisticated, as it is trained to identify only the “specific antigen”, but PPRs are cus

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Bouktila, Dhia, and Yosra Habachi. "PRRs and WAKs: PAMPs and DAMPs Detectors." In An Introduction to Plant Immunity. BENTHAM SCIENCE PUBLISHERS, 2021. http://dx.doi.org/10.2174/9781681088020121010015.

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Sud, V., D. J. van der Windt, and A. Tsung. "Toll-Like Receptors, PAMPs, and DAMPs in Hepatotoxicity." In Comprehensive Toxicology. Elsevier, 2018. http://dx.doi.org/10.1016/b978-0-12-801238-3.64266-6.

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Zhang, Yunwei, Susan J. Kim, Hongji Zhang, and Allan Tsung. "Toll-Like Receptors, PAMPs, and DAMPs in Hepatotoxicity." In Reference Module in Biomedical Sciences. Elsevier, 2025. https://doi.org/10.1016/b978-0-323-95488-4.00270-9.

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"3. Zelluläre Rezeptoren für pathogene Strukturmuster (DAMPs und PAMPs)." In Multiples Organversagen. De Gruyter, 2018. http://dx.doi.org/10.1515/9783110536522-003.

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Fehri, Emna, Emna Ennaifer, Monia Ardhaoui, Haifa Tounsi, Rahima Bel Haj Rhouma, and Samir Boubaker. "TLR AND CANCER: THE ENIGMATIC CROSS TALK." In Thirty Years since the Discovery of Toll-Like Receptors. IntechOpen, 2024. http://dx.doi.org/10.5772/intechopen.1004101.

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The connection between inflammation and cancer has been well recognized at the epidemiological, biological, and pharmacological levels. Unresolved chronic inflammation is implicated in most stages of cancer development and thus can induce certain solid tumors. The molecular regulators of these linkages are emerging and should be well-decorticated. Toll-like receptors (TLRs) recognize pathogen/microbe-associated molecular patterns (PAMPs/MAMPs) and death–associated molecular patterns (DAMPs) secreted from dying or damaged cells of the host. TLRs can be pro and anti-tumorigenic depending on the

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Gelen, Volkan, Abdulsamed Kükürt, Emin Şengül, Ömer Faruk Başer, and Mahmut Karapehlivan. "Can Polyphenols be Used as Anti-Inflammatory Agents against Covid-19 (SARS-CoV-2)-Induced Inflammation?" In Phenolic Compounds [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.98684.

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Covid-19 is the causative agent of a beta coronavirus that causes severe inflammatory pneumonia, so excessive inflammation is considered a risk factor for the disease. In Covid-19 disease, an inflammatory response develops in the body. It has been reported as a result of various studies that this response causes damage to various organs and tissues, especially the lungs. According to reports, cytokine storms are largely responsible for death in such patients. Some of the consequences of severe inflammation and cytokine storms include acute respiratory distress syndrome, acute lung injury, and

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Rosales, Vicente Pérez. "A voyage across the pampas to Buenos Aires. — The road to Uspallata. — Rosario. —The Parana River. — Buenos Aires. — The ex-dictator Don Juan Manuel Rosas. ." In Times Gone By. Oxford University PressNew York, NY, 2003. http://dx.doi.org/10.1093/oso/9780195117615.003.0024.

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Abstract When you leave foggy Llanquihue and its damp forests and travel to the northern regions, everything there seems drier, more arid than it really is; and so, when I suddenly found myself on the road from the town of Santa Rosa de los Andes to Mendoza, knowing that to the north of me the mountainous region became more barren by the mile until it turned into the sands and rocks of Atacama, I came to think that in all of Chile there could be nothing more useless to mankind than these vast highlands that separate us from the Argentine Republic. But even in the mind of one who has grown up i

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Тези доповідей конференцій з теми "PAMPs and DAMP"

De Sena, Idna Lara Goes. "RELAÇÃO ENTRE O INFLAMASSOMA E A COVID-19 GRAVE." In I Congresso Brasileiro de Imunologia On-line. Revista Multidisciplinar em Saúde, 2021. http://dx.doi.org/10.51161/rems/986.

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INTRODUÇÃO: O inflamassoma é um complexo multiproteico formado no citosol em resposta aos PAMPs e DAMPs. Sua função é gerar as formas ativas das citocinas IL-1β e IL-18 que, antes de serem liberadas das células, são clivadas pela caspase-1, tornando-se ativas para promoverem a resposta inflamatória. A ativação do inflamassoma tem como consequência a piroptose, uma forma inflamatória de morte celular programada de macrófagos caracterizada pelo inchaço das células, perda da integridade da membrana plasmática e liberação de citocinas pró-inflamatórias (IL-1β, IL-18, TNF-α, IL-6 e IL-8). OBJETIVO:

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Silva, Jordana Ribeiro da, CARLOS HENRIQUE SANTOS, JULIANA COSTA PARRIÃO DE OLIVEIRA, KAROLINE NUNES RODRIGUES VIANA, and PABLO DIEGO DUARTE DOVERA. "A IMUNOLOGIA E A DOENÇA DE PARKINSON." In II Congresso Brasileiro de Imunologia On-line. Revista Multidisciplinar em Saúde, 2022. http://dx.doi.org/10.51161/ii-conbrai/6881.

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Introdução: A doença Parkinsoniana (DP) é uma doença neurodegenerativa, que afeta mais de 1% da população, na idade de 60 anos, em indivíduos com mais de 85 anos, essa prevalência chega a 5%. Além do avanço da idade sobre o risco de desenvolver essa patologia, o gênero, principalmente o masculino, aparece como fator de predisposição para a doença. Na sintomatologia observa-se manifestações tanto motoras/não-motoras que incluem desde tremores, rigidez, dificuldade na execução de movimentos voluntários, a lentificação dos movimentos, instabilidade postural e também sintomas neuropsiquiátricos co

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