Добірка наукової літератури з теми "Paired Helical Filaments"
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Статті в журналах з теми "Paired Helical Filaments"
Iqbal, K., I. Griindke-Iqbnl, and H. M. Wisniewaki. "ALZHEIMER PAIRED HELICAL FILAMENTS." Journal of Neuropathology and Experimental Neurology 44, no. 3 (May 1985): 366. http://dx.doi.org/10.1097/00005072-198505000-00187.
Повний текст джерелаMetuzals, J. "Neurofilaments and Paired Helical Filaments." Proceedings, annual meeting, Electron Microscopy Society of America 43 (August 1985): 740–43. http://dx.doi.org/10.1017/s0424820100120357.
Повний текст джерелаYoshida, Hirotaka, and Yasuo Ihara. "? in Paired Helical Filaments Is Functionally Distinct from Fetal ?: Assembly Incompetence of Paired Helical Filament-?" Journal of Neurochemistry 61, no. 3 (September 1993): 1183–86. http://dx.doi.org/10.1111/j.1471-4159.1993.tb03642.x.
Повний текст джерелаChen, Shu G. "Molecular profiling of paired helical filaments." Journal of Alzheimer's Disease 3, no. 5 (September 30, 2001): 467–69. http://dx.doi.org/10.3233/jad-2001-3505.
Повний текст джерелаAnderton, Brian H. "Paired helical filaments and the cytoskeleton." Nature 335, no. 6190 (October 1988): 497–98. http://dx.doi.org/10.1038/335497a0.
Повний текст джерелаLhara, Yasuo, and Jun Kondo. "Polypeptide Composition of Paired Helical Filaments." Annals of Medicine 21, no. 2 (January 1989): 121–25. http://dx.doi.org/10.3109/07853898909149198.
Повний текст джерелаMori, H., J. Kondo, S. Kuzuhara та Y. Ihara. "UBIQUITIN IN ALZHEIMERʼS PAIRED HELICAL FILAMENTS". Journal of Neuropathology and Experimental Neurology 46, № 3 (травень 1987): 332. http://dx.doi.org/10.1097/00005072-198705000-00009.
Повний текст джерелаKidd, Michael. "The history of the paired helical filaments." Journal of Alzheimer's Disease 9, s3 (July 27, 2006): 71–75. http://dx.doi.org/10.3233/jad-2006-9s309.
Повний текст джерелаIhara, Yasuo. "Neurofibrillary tangles/paired helical filaments (1981–83)." Journal of Alzheimer's Disease 9, s3 (July 27, 2006): 209–17. http://dx.doi.org/10.3233/jad-2006-9s324.
Повний текст джерелаGRAY, E. G., M. PAULA-BARBOSA, and A. ROHER. "ALZHEIMER'S DISEASE: PAIRED HELICAL FILAMENTS AND CYTOMEMBRANES." Neuropathology and Applied Neurobiology 13, no. 2 (March 1987): 91–110. http://dx.doi.org/10.1111/j.1365-2990.1987.tb00174.x.
Повний текст джерелаДисертації з теми "Paired Helical Filaments"
Wischik, Claude M. "The structure and biochemistry of paired helical filaments in Alzheimer's disease." Thesis, University of Cambridge, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.315916.
Повний текст джерелаLi, Li. "Tryptophan and proline scanning mutagenesis a tool to study the aggregation of tau protein into Alzheimer paired helical filaments /." [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=967241790.
Повний текст джерелаGuix, Ràfols Francesc Xavier. "Study of the pathophysiological role of nitric oxide on the amyloid-induced toxicity attending to the biochemical modifications and cellular damages." Doctoral thesis, Universitat Pompeu Fabra, 2009. http://hdl.handle.net/10803/7162.
Повний текст джерелаPer altra banda, des de la identificació dels agregats d'A i la subseqüent formació dels cabdells neurofibrilars (NFT) com a els dos trets distintius de la malaltia, un gran esforç s'ha dedicat a establir els mecanismes moleculars que uneixen ambdós processos. Aquesta tesi demostra que el peroxinitrit format a partir de l'agregació de d'Ai la conseqüent nitrotirosinació de proteïnes, potencia l'agregació de la proteïna tau en forma de fibres. D'aquesta forma, la nitrotirosinació de la proteïna triosafosfat isomerasa (TPI) podria ser el vincle entre la toxicitat derivada del agregats d'Ai la patologia derivada de la proteïna tau. Per tant, la nitrotirosinació de la TPI podria explicar la progressió temporal que ocorre als cervells de pacients amb la malaltia d'Alzheimer des de la toxicitat induïda per l'Ai l'aparició dels NFT. Els resultats presentats en aquesta tesi podrien obrir nous aspectes en la recerca de la malaltia d'Alzheimer així com en altres malalties que cursin amb estrès oxidatiu i plegament erroni de proteïnes.
This thesis demonstrates that amyloid ß-peptide (Aß)-induced peroxynitrite contributes to the switch of the Aβ42/Aβ40 ratio that occurs in Alzheimer's disease (AD). Since Aβ42 is more toxic due to its higher aggregation and stability, it contributes to the trigger of the disease. In addition the aggregation of Aβ42 in form of the highly toxic oligomers is incremented by the presence of peroxynitrite. Moreover, these nitro-Aß42 oligomers are more toxic than those non-nitrated. All these results support the important role of peroxynitrite in AD etiology.
Furthermore, since the identification of Aß accumulation and the subsequent formation of neurofibrillary tangles (NFT) as the two defining pathological hallmarks of AD, a fair amount of research on AD has been driven by the need to find the molecular mechanism linking Aß and NFT. This thesis shows the Aß-induced peroxynitrite, and the consequent nitrotyrosination of proteins, promotes tau fibrillization. Thus triosephosphate isomerase (TPI) nitrotyrosination could be the link between Aß-induced toxicity and tau pathology. Therefore, TPI nitrotyrosination may explain the temporal progression from Aß toxicity to NFT formation in AD brain. The work presented in this thesis could open a novel angle in the research of the pathophysiology of AD and could also have an impact to the research in other neurodegenerative diseases involving oxidative stress and protein misfolding.
Li, Li [Verfasser]. "Tryptophan and proline scanning mutagenesis : a tool to study the aggregation of tau protein into Alzheimer paired helical filaments / presented by Li Li." 2003. http://d-nb.info/967241790/34.
Повний текст джерелаЧастини книг з теми "Paired Helical Filaments"
Wisniewski, H. M., and K. Iqbal. "Paired Helical Filaments (PHF): Update 1988." In Genetics and Alzheimer’s Disease, 157–63. Berlin, Heidelberg: Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-73647-6_17.
Повний текст джерелаMandelkow, E., M. von Bergen, A. Marx, J. Biernat, and E. M. Mandelkow. "The Search for structure of tau and paired helical filaments." In Alzheimer: 100 Years and Beyond, 355–64. Berlin, Heidelberg: Springer Berlin Heidelberg, 2006. http://dx.doi.org/10.1007/978-3-540-37652-1_45.
Повний текст джерелаMandelkow, E., J. Biernat, B. Lichtenberg-Kraag, G. Drewes, H. Wille, N. Gustke, K. Baumann, and E. M. Mandelkow. "Microtubules, Tau Protein,and Paired Helical Filaments in Alzheimer’s Disease." In The Cytoskeleton, 143–60. Berlin, Heidelberg: Springer Berlin Heidelberg, 1995. http://dx.doi.org/10.1007/978-3-642-79482-7_16.
Повний текст джерелаDelacourte, A., and A. Defossez. "Paired Helical Filaments in Alzheimer’s Disease: Their Formation and Transformation." In Immunology and Alzheimer’s Disease, 55–67. Berlin, Heidelberg: Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-46634-2_6.
Повний текст джерелаMandelkow, E. M., J. Biernat, B. Lichtenberg-Kraag, G. Drewes, H. Wille, N. Gustke, K. Baumann, and E. Mandelkow. "Phosphorylation of Tau and Its Relationship with Alzheimer Paired Helical Filaments." In Alzheimer’s Disease: Lessons from Cell Biology, 103–20. Berlin, Heidelberg: Springer Berlin Heidelberg, 1995. http://dx.doi.org/10.1007/978-3-642-79423-0_10.
Повний текст джерелаMandelkow, Eckhard, Peter Friedhoff, Jacek Biernat, and Eva-Maria Mandelkow. "The Conformations of Tau Protein and its Aggregation into Alzheimer Paired Helical Filaments." In Advances in Behavioral Biology, 223–33. Boston, MA: Springer US, 1998. http://dx.doi.org/10.1007/978-1-4615-5337-3_32.
Повний текст джерелаOtvos, Laszlo, Virginia M. Y. Lee, Susan Leight, Peter Davies, and Ralf Hoffmann. "Multiphosphorylated synthetic peptides as antigens and immunogens in Alzheimer’s disease paired helical filaments." In Peptides Frontiers of Peptide Science, 695–97. Dordrecht: Springer Netherlands, 2002. http://dx.doi.org/10.1007/0-306-46862-x_304.
Повний текст джерелаSelkoe, Dennis J., Carmela Abraham, and C. G. Rasool. "Molecular Properties of Paired Helical Filaments and Senile Plaque Amyloid Fibers in Alzheimer’s Disease." In Advances in Behavioral Biology, 37–42. Boston, MA: Springer US, 1986. http://dx.doi.org/10.1007/978-1-4613-2179-8_5.
Повний текст джерелаLee, Virginia M. Y., and Laszlo Otvos. "Identification of an abnormal phosphorylation site in Alzheimer’s disease paired helical filaments using synthetic peptides." In Peptides, 109–12. Dordrecht: Springer Netherlands, 1992. http://dx.doi.org/10.1007/978-94-011-2264-1_34.
Повний текст джерелаSelkoe, Dennis J., and Carmela Abraham. "Biochemical and Structural Studies of Paired Helical Filaments and Senile Plaque Amyloid in Alzheimer’s Disease." In Amyloidosis, 709–15. Boston, MA: Springer US, 1986. http://dx.doi.org/10.1007/978-1-4613-2199-6_90.
Повний текст джерелаТези доповідей конференцій з теми "Paired Helical Filaments"
Stork, Larissa Rosa, Lucca Stephani Ribeiro, Izabella Savergnini Deprá, Luísa D’Ávila Camargo, and Maria Angélica Santos Novaes. "Tau protein and its role in Alzheimer’s disease physiopathology: a literature review." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.132.
Повний текст джерела