Добірка наукової літератури з теми "P53, 14-3-3"
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Статті в журналах з теми "P53, 14-3-3":
Mühlmann, Gilbert, Dietmar Öfner, Matthias Zitt, Hannes M. Müller, Hans Maier, Patrizia Moser, Kurt W. Schmid, Marion Zitt, and Albert Amberger. "14-3-3 Sigma And p53 Expression in Gastric Cancer and Its Clinical Applications." Disease Markers 29, no. 1 (2010): 21–29. http://dx.doi.org/10.1155/2010/470314.
Yang, Heng-Yin, Yu-Ye Wen, Chih-Hsin Chen, Guillermina Lozano та Mong-Hong Lee. "14-3-3σ Positively Regulates p53 and Suppresses Tumor Growth". Molecular and Cellular Biology 23, № 20 (15 жовтня 2003): 7096–107. http://dx.doi.org/10.1128/mcb.23.20.7096-7107.2003.
CHEN, DE-YU, DONG-FANG DAI, YE HUA та WEN-QING QI. "p53 suppresses 14-3-3γ by stimulating proteasome-mediated 14-3-3γ protein degradation". International Journal of Oncology 46, № 2 (7 листопада 2014): 818–24. http://dx.doi.org/10.3892/ijo.2014.2740.
Doveston, Richard G., Ave Kuusk, Sebastian A. Andrei, Seppe Leysen, Qing Cao, Maria P. Castaldi, Adam Hendricks, et al. "Small-molecule stabilization of the p53 - 14-3-3 protein-protein interaction." FEBS Letters 591, no. 16 (August 2017): 2449–57. http://dx.doi.org/10.1002/1873-3468.12723.
Rawlinson, Imogen, Carol McMenemy та David Greenhalgh. "P19 Inducible 14-3-3 sigma/stratifin ablation accelerates malignant progression in HK1.ras/fos-Δ5PTENflx transgenic mouse skin carcinogenesis". British Journal of Dermatology 189, № 1 (липень 2023): e21-e21. http://dx.doi.org/10.1093/bjd/ljad174.040.
Yang, Wensheng, David T. Dicker, Jiandong Chen, and Wafik S. El-Deiry. "CARPs enhance p53 turnover by degrading 14-3-3σ and stabilizing MDM2." Cell Cycle 7, no. 5 (March 2008): 670–82. http://dx.doi.org/10.4161/cc.7.5.5701.
Rajagopalan, Sridharan, Robert S. Sade, Fiona M. Townsley, and Alan R. Fersht. "Mechanistic differences in the transcriptional activation of p53 by 14-3-3 isoforms." Nucleic Acids Research 38, no. 3 (November 20, 2009): 893–906. http://dx.doi.org/10.1093/nar/gkp1041.
Schumacher, Benjamin, Justine Mondry, Philipp Thiel, Michael Weyand, and Christian Ottmann. "Structure of the p53 C-terminus bound to 14-3-3: Implications for stabilization of the p53 tetramer." FEBS Letters 584, no. 8 (March 3, 2010): 1443–48. http://dx.doi.org/10.1016/j.febslet.2010.02.065.
Waterman, Matthew J. F., Elena S. Stavridi, Jennifer L. F. Waterman, and Thanos D. Halazonetis. "ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins." Nature Genetics 19, no. 2 (June 1998): 175–78. http://dx.doi.org/10.1038/542.
Montano, Ximena. "Common amino acid sequence motifs in p53, 14-3-3 and Akt protein families." FEBS Letters 507, no. 2 (October 18, 2001): 237–40. http://dx.doi.org/10.1016/s0014-5793(01)02903-9.
Дисертації з теми "P53, 14-3-3":
LeBron, Cynthia. "Regulation of MDMX nuclear import and degradation by Chk2 and 14-3-3." [Tampa, Fla.] : University of South Florida, 2007. http://purl.fcla.edu/usf/dc/et/SFE0001992.
Radhakrishnan, Vijayababu, Charles Putnam, Wenqing Qi, and Jesse Martinez. "P53 suppresses expression of the 14-3-3gamma oncogene." BioMed Central, 2011. http://hdl.handle.net/10150/610345.
Seco, Martins Marques Neves João Filipe. "NMR study of 14-3-3 protein-protein interactions and modulation thereof by small molecules." Thesis, Lille, 2019. http://www.theses.fr/2019LIL1S108.
14-3-3 proteins are adapter proteins that exert their biological functions by modulating the activity of hundreds of proteins. This remarkable interactome makes 14-3-3 proteins influent actors in many cellular events and, by consequence, in several pathologies. The selective stabilization or inhibition of 14-3-3 protein-protein interactions (PPIs) are therefore seen as promising approaches for finding innovative therapies for a number of conditions like Alzheimer’s, cancer or Parkinson. Our first objective towards finding small molecule modulators of these targets was to obtain the molecular detail of 14-3-3 PPIs. To this end, using Nuclear Magnetic Resonance (NMR), we assigned the backbone chemical shifts of 14-3-3σ. We then studied the 14-3-3/phosphorylated Tau interaction and found that Tau binds strictly within the amphipathic binding grove of 14-3-3 and can anchor in both monomers of the 14-3-3 dimer. We also studied the 14-3-3/p53 interaction and showed by NMR, that intramolecular interactions within the peptide define a conformation that drives the affinity towards 14-3-3. 2019We then focused on the optimization of NMR assays for screening and characterization of the effect of small-molecules binding to 14-3-3 or 14-3-3 complexes with target’s phosphopeptides. We used, for example, phospho-mimetic peptides to inhibit the Tau/14-3-3 interaction. In a different strategy, we screened a fragment library against 14-3-3σ and found three hits binding to different regions of the protein. Using our NMR assays we further characterized small molecules binding 14-3-3 complexes with, for example, p53 and p65 peptides and demonstrated the stabilization capacity of some compounds
Alleman, Cécile. "Accès synthétique au châssis [5-8-5] de la fusicoccine-A pour la synthèse d’analogues simplifiés en vue d'étudier les interactions protéine-protéine." Electronic Thesis or Diss., Université de Rennes (2023-....), 2023. http://www.theses.fr/2023URENS090.
In biological media, protein-protein interactions (PPI) are of huge importance, as they allow the regulation of many cellular events. PPI classically involve two partners: an adapter protein and its effector protein(s) regulated either in a positive or a negative manner. Inhibition of PPI has thus been considered as a solid therapeutic approach. On the other hand, stabilization of PPI remains scarcely investigated, but may lead to new promising approaches. This project focuses on the 14-3-3 family adapter protein which interacts with more than 200 protein partners. Among them, p53 protein is subjected to a lot of studies as this tumor suppressor protein regulates multiple biological processes (DNA repair, apoptosis). However, those major functions appear to be silenced in most cancer cases, thus allowing tumor cells proliferation. Some studies have shown that stabilization of the 14-3-3/p53 pair with the help of a molecular glue permitted to restore tumor suppressor activity of p53. Among the examined molecular glues, the fusicoccin-A (FC-A) natural product is shown to lodge in the valley formed by 14-3-3 and increases stabilization of the 14-3-3/p53 interaction. In this context, to enlarge the p53/14-3-3 molecular glue library, this project focuses on the access to simplified FC-A analogs through the synthesis of tricyclic scaffold. [6-8-5] analogs from an aromatic substrate are envisaged, as well as [5-8-5] analogs from a cyclopentane derivative, closer to the target structure. Various strategies have been explored in order to access these analogs
Частини книг з теми "P53, 14-3-3":
Galat, Andrzej, and Sylvie Riviere. "Genes and the cellular localization of PPlases." In Peptidyl–Prolyl Cis/Trans lsomerases, 32–35. Oxford University PressOxford, 1998. http://dx.doi.org/10.1093/oso/9780198502883.003.0003.
Taber, Douglass. "The Toste Synthesis of ( + )-Fawcettimine." In Organic Synthesis. Oxford University Press, 2011. http://dx.doi.org/10.1093/oso/9780199764549.003.0091.
Ito, M., H. Hiroi, T. Urano, M. Momoeda, Y. Hosokawa, R. Tsutumi, M. Koizumi, T. Yano, S. Inoue, and Y. Taketani. "A Progesterone Responsive Gene, 14-3-3 Tau, Upregulates the Transcriptional Activity of Progesterone Receptor B (PR-B) in Uterine Endometrium." In Posters I, P3–14—P3–14. Endocrine Society, 2010. http://dx.doi.org/10.1210/endo-meetings.2010.part3.p1.p3-14.
Cheng, Theresa M., Vinod Ganju, Steve R. Ritland, Gobinda Sarkar, and Robert B. Jenkins. "[14] Analysis of p53 mutations in human gliomas by RNA single-strand conformational polymorphism." In Methods in Neurosciences, 210–24. Elsevier, 1995. http://dx.doi.org/10.1016/s1043-9471(06)80092-3.
Тези доповідей конференцій з теми "P53, 14-3-3":
Danilov, Alexey V., Amitabh Srivastava, Elena V. Feofanova, Leigh Ann Humphries, James Direnzo та Murray Korc. "Abstract 3076:p53 homologue p63 trans-activates epidermal growth factor (EGF) receptor and 14-3-3α and thus promotes tumorigenesis and chemoresistance in pancreatic cancer". У Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-3076.
Xu, Jia, Sunil Acharya, Ozgur Sahin, Lin Zhang, Frank J. Lowery, Aysegul A. Sahin, Xiang H. f. Zhang, Mien-Chie Hung та Dihua Yu. "Abstract LB-202: 14-3-3ζ turns TGF-β's function from tumor suppressor to metastasis promoter in breast cancer by contextual changes of Smad partners from p53 to Gli2". У Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-lb-202.
Rodrigues, Antonio Rony da S. P., and Edinalda Maria Cavalcante. "ESTUDO GENÉTICO DO CÂNCER DE TIREOIDE – UMA REVISÃO." In I SIMPÓSIO MARANHENSE DE GENÉTICA E GENÔMICA EM SAÚDE. Doity - Plataforma de Eventos, 2022. http://dx.doi.org/10.55664/simaggens2022.005.
Trejo, Leonard J., and Gregory W. Lewis. "Individual differences in classification of transient, isoluminant, chromatic signals: a behavioral and electrophysiological analysis." In OSA Annual Meeting. Washington, D.C.: Optica Publishing Group, 1989. http://dx.doi.org/10.1364/oam.1989.fk1.
Papapetrou, Georghios Dorou, Chia Pei Chuen, Mohd Nur Adzizie Mahamad, Ros Aliza Md Rabi, and Yong Han Seah. "FDP Simulation Studies for Green Fields Cluster Development in Less than 30 Days Utilizing Cloud Technologies." In ADIPEC. SPE, 2022. http://dx.doi.org/10.2118/211415-ms.
Pratt, Sheila Alhana, Valeria Sanabria, Ana Soskin, Aurora Rocio Rizzi, and Marcos Cabrera. "ADENOID CYSTIC CARCINOMA OF THE BREAST." In Scientifc papers of XXIII Brazilian Breast Congress - 2021. Mastology, 2021. http://dx.doi.org/10.29289/259453942021v31s1014.
Звіти організацій з теми "P53, 14-3-3":
Halzonetis, Thanos. Interaction of p53 with 14-3-3. Fort Belvoir, VA: Defense Technical Information Center, May 2002. http://dx.doi.org/10.21236/ada405400.
Halazonetis, Thanos. Interaction of p53 with 14-3-3. Fort Belvoir, VA: Defense Technical Information Center, May 2000. http://dx.doi.org/10.21236/ada390713.
Dorman, Eleanor, Zara Markovic-Obiago, Julie Phillips, Richard Szydlo, and Darren K. Patten. Wellbeing in UK Frontline Healthcare Workers During Peaks One and Three of the COVID-19 Pandemic: A Retrospective Cross-Sectional Analysis. Science Repository, December 2022. http://dx.doi.org/10.31487/j.ejgm.2022.01.01.