Добірка наукової літератури з теми "Outils chimiques"
Оформте джерело за APA, MLA, Chicago, Harvard та іншими стилями
Ознайомтеся зі списками актуальних статей, книг, дисертацій, тез та інших наукових джерел на тему "Outils chimiques".
Біля кожної праці в переліку літератури доступна кнопка «Додати до бібліографії». Скористайтеся нею – і ми автоматично оформимо бібліографічне посилання на обрану працю в потрібному вам стилі цитування: APA, MLA, «Гарвард», «Чикаго», «Ванкувер» тощо.
Також ви можете завантажити повний текст наукової публікації у форматі «.pdf» та прочитати онлайн анотацію до роботи, якщо відповідні параметри наявні в метаданих.
Статті в журналах з теми "Outils chimiques":
Kahn, A. "Des outils chimiques pour la biologie." médecine/sciences 3, no. 9 (1987): 556. http://dx.doi.org/10.4267/10608/3738.
Jacyk, William R., Ellen Tabisz, Mark Badger, and Don Fuchs. "Chemical Dependency in the Elderly: Identification Phase." Canadian Journal on Aging / La Revue canadienne du vieillissement 10, no. 1 (1991): 10–17. http://dx.doi.org/10.1017/s0714980800007212.
Séby, Fabienne, Jean Dumont, Christine Gleyzes, Mathieu Menta, Véronique Vacchina, and Maïté Bueno. "Analyse de formes chimiques et de nanoparticules dans les échantillons d’eau : méthodes analytiques, préconcentration et validation." Revue des sciences de l’eau 28, no. 1 (April 21, 2015): 27–32. http://dx.doi.org/10.7202/1030004ar.
DUBOIS-BRISSONNET, Florence, Romain BRIANDET, and Marie-Noëlle BELLON-FONTAINE. "Agents chimiques ou naturels : des outils de maîtrise de la contamination microbiologique des surfaces." Bulletin de l'Académie vétérinaire de France, no. 1 (2006): 161. http://dx.doi.org/10.4267/2042/47828.
Marano, Francelyne. "Les méthodes alternatives à l’expérimentation animale, présent et futur." Biologie Aujourd’hui 217, no. 3-4 (2023): 199–205. http://dx.doi.org/10.1051/jbio/2023035.
Fortin, Émilie. "PROHIBITION PRESCRITE AU SOUS-PARAGRAPHE B DE L’ARTICLE PREMIER DE LA CONVENTION SUR LES ARMES CHIMIQUES : SOMMES-NOUS EN PRÉSENCE D’UN EFFET GÉNÉRATEUR D’UNE RÈGLE DU DROIT INTERNATIONAL COUTUMIER ?" Revue québécoise de droit international 29, no. 2 (May 22, 2018): 37–74. http://dx.doi.org/10.7202/1046508ar.
Persoons, R., A. Maitre, B. Sawicki, D. Dumont, M. A. Denis, A. Karinthi-Doyon, and S. Touche. "Outils d’aide à l’évaluation des risques chimiques en établissement de santé : retour d’expériences d’un réseau inter-CHU." Archives des Maladies Professionnelles et de l'Environnement 70, no. 1 (February 2009): 3–12. http://dx.doi.org/10.1016/j.admp.2008.10.023.
Marjoua, A., P. Olive, and C. Jusserand. "Apports des outils chiniques et isotopiques à l'identification des origines de la salinisation des eaux : Cas de la nappe de La Chaouia côtière (Maroc)." Revue des sciences de l'eau 10, no. 4 (April 12, 2005): 489–505. http://dx.doi.org/10.7202/705290ar.
Pilliere, F., and A. Bijaoui. "Outils à disposition des médecins du travail pour la mise en place pratique d’une surveillance biologique de l’exposition aux produits chimiques." Archives des Maladies Professionnelles et de l'Environnement 65, no. 2-3 (May 2004): 171–73. http://dx.doi.org/10.1016/s1775-8785(04)93213-4.
Ben Moussa, Amor, Houcem Mzali, Hatem Elmejri, and Sarra Bel Haj Salem. "Apport des outils hydrogéochimiques à l'évaluation de la qualité et l'aptitude des eaux souterraines à l'irrigation : cas de la nappe phréatique de la basse vallée de Medjerda, Tunisie Nord-Orientale." La Houille Blanche, no. 5-6 (December 2019): 35–44. http://dx.doi.org/10.1051/lhb/2019053.
Дисертації з теми "Outils chimiques":
BALAVOINE, FABRICE. "Conception et preparation de nouveaux outils chimiques pour la biologie structurale." Paris 11, 1998. http://www.theses.fr/1998PA112352.
Gerard-Hirne, Tom. "Outils chimiques pour l'étude de la 5-hydroxyméthylcytosine, une base modifiée de l'ADN." Thesis, Paris 6, 2015. http://www.theses.fr/2015PA066081/document.
5-hydroxymethylcytosine (5hmC) is a modified DNA base, who was until recently believed be a minor modification, resulting of oxidative damage. However, results published in 2009 have challenged this understanding. Indeed, 5hmC is abundant in some cell types and its formation is an active process, mediated by specific enzymes (TET1-3) using another modified DNA base, 5-methylcytosine (5mC). These recent discoveries raise the question of the biological role of 5hmC. Indeed, if the role of 5mC in gene expression regulation is established, the biological role of 5hmC is still in study and require the development of specific methods. We participated in the development of methods to study 5hmC and its partner proteins using chemical, biochemical and analytical tools. We showed that mass spectrometry is a powerful tool to quantify global methylation levels and adapted a method, using liquid chromatography coupled to tandem mass spectrometry to study hydroxymethylation. We have also taken part in the development of two 5hmC specific labeling methods: (i) an enzymatic strategy, using a glucosyltransferase and a chemically modified glucose donor, allowing the introduction of a probe by a bio-orthogonal reaction; (ii) a chemical strategy based on the selective oxidation of the 5hmC allylic alcohol. Finally, we have designed, synthesized and assessed the properties of photoactivable oligonucleotidic probes in order to identify proteins interacting with 5hmC
Roger, Thomas. "Outils chimiques pour l’étude et la compréhension du rôle du sulfure d’hydrogène en biologie." Thesis, Paris 5, 2013. http://www.theses.fr/2013PA05P626/document.
Pas de résumé en anglais
Duchemin, Matthieu. "Validation des outils immunotoxicologiques pour l'étude des effets biologiques des contaminants chimiques en milieu marin." Brest, 2007. http://www.theses.fr/2007BRES2008.
Industrial, agricultural, and urban sewages, loaded in various pollutants, draw a chronic ecotoxicological risk on coastal marine ecosystems. For twenty years, the toxic effects of chemicals on the immune system have been studied in ail ecological groups, especially in bivalves, to characterize that risk in aquatic ecosystems. To define an operating framework of these immunotoxicological tools, several methodological questions were addressed. Then, was studied the impact of natural endogenous and environmental factors on the immunotoxic signal emitted by a pollutant. Through a French and Canadian framework, two-year surveys n the blue mussel, Mytilus edulis and in the Pacific oyster, Crassostrea gigas, took place in France (Rade de Brest) and gave evidence of the critical role of sex and reproductive cycle on the seasonal patterns of immune parameters, despite the environmental factors of the water column. In the meantime, batches of “in tubo” exposures of blue mussels, in Quebec, at two different seasons, showed also the importance of sex and reproductive cycle in the measurement of the immunotoxic signal, but, most of ail, in the immunotoxic sensitivity. Finally, this research built an operating framework for the use of immunotoxicoiogical biomarkers, for chemical risk assessment in coastal marine ecosystems. Furthermore, these findings showed the dramatic role of the studied confounding factors to assess with accuracy the danger of chemical
Doublet, Marie-Liesse. "Grandeurs Locales et Liaisons Chimiques :Des Outils d'Analyses pour l'Etude des Propriétés Macroscopiques des Solides Périodiques." Habilitation à diriger des recherches, Université Montpellier II - Sciences et Techniques du Languedoc, 2006. http://tel.archives-ouvertes.fr/tel-00185445.
Qu'il s'agisse des propriétés physiques comme le transport électronique et le magnétisme, ou des propriétés chimiques comme la réactivité chimique et l'oxydo-réduction, une approche locale visant à modéliser les interactions microscopiques au sein des différents systèmes doit permettre, dans le principe, de reproduire convenablement leurs propriétés macroscopiques (de basse énergie). Pour être efficace, cette approche nécessite une définition correcte de l'entité électronique active mais aussi des grandeurs physiques locales qui la caractérisent, incluant les effets de l'environnement. Établir une corrélation directe entre la nature de la liaison chimique (microscopique) et les propriétés physico-chimiques (macroscopiques) des matériaux est donc l'objectif dans lequel j'ai inscrit mes travaux de recherches depuis ma soutenance de Thèse en septembre 1994 et mon stage postdoctoral à l'Université libre d'Amsterdam. Mon travail explore à la fois des aspects méthodologiques et des applications, et vise à une meilleure description et une meilleure compréhension des phénomènes électroniques gouvernant l'arrangement structural des matériaux et les propriétés physico-chimiques qui en découlent. Une grande variété de propriétés a donc été abordée (transport, magnétisme, réactivité chimique et réactions électrochimiques), avec laquelle une grande variété de systèmes cristallins (moléculaires, covalents, organiques, inorganiques). A l'interface entre la physique et la chimie, ces études ont nécessité l'utilisation de formalismes théoriques différents mais également un investissement important dans le monde expérimental pour une bonne lecture des caractérisations physico-chimiques et des objectifs industriels.
Rosenfeld, Carine. "Les systèmes microfluidiques : de nouveaux outils en génie de la polymérisation. Application à la synthèse de polymères et copolymères à blocs." Université Louis Pasteur (Strasbourg) (1971-2008), 2007. https://publication-theses.unistra.fr/public/theses_doctorat/2007/ROSENFELD_Carine_2007.pdf.
The aim of this work is to study TIPNO-mediated polymerization and copolymerization in a microfluidic device composed of one or two serial continuous microtube reactors. The results are compared to those obtained in conventional batch reactor. Molecular weights and polydispersity indices of (co)polymers are continuously online monitored by size exclusion chromatography. According to the polymerized monomer, different behaviors are observed. For styrene polymerization, the reduction of the characteristic length of the reactor does not seem to affect the control over the polymerization. Conversely, the control of the n-butyl acrylate polymerization, is significantly affected by the reactor’s dimensions. The control is only maintained in the microfluidic device. Concerning the synthesis of block copolymers, the liquid comonomer is mixed with the viscous first block solution by means of a Tjunction or a microstructured mixer. Different geometries and mixing principles have been studied. For multilamination micromixers, the polydispersity index of the copolymers follows a linear relationship with the Reynolds number. Thus, beside the operating conditions, the choice of the micromixer geometry and dimension is essential to control the copolymerization (molecular weights, polydispersity indices…)
Noël, Maxence. "Etude des relations structure-fonction des sialyltransférases humaines : développement de nouveaux outils." Thesis, Lille 1, 2018. http://www.theses.fr/2018LIL1S109/document.
Sialylation is a major modification of glycoproteins and glycolipids and is involved in cellular and molecular processes. The sialylation reaction is catalyzed by sialyltransferases, a group of golgian glycosyltransferases using an activated sugar donor in the form of CMP-sialic acid. These enzymes, 20 in humans, have redundant enzymatic activities and have a very fine specificity towards the accepting substrate. Their deregulation leads to altered sialylation profiles in pathological situations but little is known about their functional organization in the cell. Techniques for studying the sialylation reaction and sialoglycoconjugates are numerous but rarely present the possibility of selectively monitoring O- or N-glycans. In this context, I have produced different recombinant and soluble sialyltransferases and developed new strategies for studying these enzymatic activities in in vitro and in cellulo assays based on the use of a non-natural sialic acid: CMP-SiaNAl. This unnatural sialic acid derivative carrying an N-alkyne group serves as a chemical reporter for the detection and visualization of sialoglycoconjugates. After having shown that this substrate is used with the same affinity as the natural substrate, I developed new tools allowing the study of sialyltransferases. In addition, I was able to provide elements of understanding as to the molecular and functional evolution of this ST6GAL1 in vertebrates, implying an evolution of its enzymatic activity in mammals
Ravalason, Holy. "Développement de nouveaux outils fongiques respectueux de l'environnement (écoprocédés) pour la production de pâtes chimiques blanchies de résineux." Aix-Marseille 1, 2009. http://www.theses.fr/2009AIX11017.
Biotechnologies can be applied to paper industry as an alternative to chemical processes for pulp and paper production. In this work advances in genomic and protein engineering were used to improve biotechnological processes applied to chemical pulps production and bleaching. In the first part of this work, the Phanerochaete chrysosporium secretome, grown on softwood chips under biopulping conditions was analysed. A proteomic approach was chosen, using the P. Chrysosporium genome. Proteomic analysis revealed the production of several enzymes involved in wood biodegradation. The secretion of some of the identified enzymes was demonstrated for the first time. Biotreated wood chips were further submitted to kraft cooking and chlorine dioxide bleaching. Fungal treatment led to an increase of pulp yield, as well as an increase of pulp final brightness and a decrease in chlorine dioxide consumption. These effects could be partially explained by the production of specific wood-degrading enzymes. In the second part, Pycnoporus cinnabarinus laccase was fused to a fungal carbohydrate binding module (CBM). The laccase-CBM was produced in Aspergillus niger, and binding capabilities of the enzyme on a cellulosic substrate and on softwood kraft pulp fibers were evaluated. Laccase-CBM and P. Cinnabarinus laccase were compared for their softwood kraft pulp biobleaching potential, in the presence of a redox mediator (hydroxybenzotriazole). The presence of the CBM could improve pulp biodelignification with laccase, leading to a decrease in the enzymatic charge, an increase of pulp final brightness, a decrease in chlorine dioxide consumption and a preservation of pulp mechanical properties. Microscopic examinations revealed a penetration of the laccase-CBM in the fiber wall, and retention of the enzyme inside the pulp fibers at the end of the enzymatic treatment
Roubinet, Benoît. "Développement de nouveaux outils chimiques pour la conception d'un système de détection fluorogénique des réactions catalysées par les polymérases." Rouen, 2015. http://www.theses.fr/2015ROUES012.
During the past decade, considerable research efforts have been devoted to the field of bioanalysis of nucleic acids, and significant achievements have been done, particularly through the development of new methods for high-throughput DNA sequencing (HTS). This was made possible thanks to advances in optical detection methods, in particular fluorescence techniques which have some advantages including high sensitivity and ease of implementation. It is in this context that this current project takes place, whose ultimate and ambitious goal is the development of a novel fluorogenic system for real-time monitoring of DNA replication process. The main objective of this Ph. D. Thesis is to obtain a first proof-of-concept through the synthesis of a novel class of thionucleotides that only differ from the natural nucleotides by the replacement of the bridging-oxygen between phosphorus atoms Pα and Pβ by a sulfur atom ("P-S-P" moiety), to increase the nucleophilic character of the anion, released upon action of DNA polymerase (thiopyrophosphate (ThioPPi) instead of pyrophosphate). Subsequent reaction of ThioPPi with thiol-reactive latent fluorophores will enable detection of this enzymatic event. The first part of this work was devoted to the rational design and structural optimization of this pro-fluorescent system. Novel water-soluble phenol-based fluorophores derived from 7- hydroxycoumarin scaffold have been synthesized and the evaluation of their photophysical properties has been done. Their subsequent conversion to thiol-sensitive fluorogenic probes (reactive toward both ThioPPi and its decomposition product thiophosphate anion) through the chemical modification of their hydroxyl group was achieved. This comprehensive study has enabled us to select some latent fluorophores exhibiting both biocompatibility and high reactivity toward thiols, suitable for targeted application. The second part was devoted to the synthesis of original thionucleotides by exploring unusual synthetic strategies leading to "P-S-P" moiety; some valuable/interesting results were obtained. The third part aimed at highlighting some of the synthesized molecules in bioanalytical experiments
Chevalier, Arnaud. "Développement de nouveaux outils chimiques pour la synthèse de sondes optiques fluorogéniques pour la détection d'activités enzymatiques en milieu biologique." Rouen, 2014. http://www.theses.fr/2014ROUES050.
Optical imaging is a continuously developing field of bio-organic chemistry over the past decades. The understanding of the physical phenomena and of the structure/photophysical properties relationship has resulted in the establishment of new strategies for the fluorogenic detection of (bio)analytes in vivo. Many tools have been developed leading to both sensitive and inexpensive diagnosis systems aiming at increasing their performances. My Ph. D. Thesis has been focused on the synthesis of new chemical tools (both quenchers and fluorescent organic dyes) for the development of new fluorogenic probes (based on FRET and/or pro-fluorescence concept) for the detection of enzymes in biological media. We proceeded to the synthesis of unsymmetrical sulforhodamines leading to novel fluorescent organic dyes whose the usefulness has been proved through the preparation of a wide range of new activatable "smart" optical bioprobes. In addition, a panel of various bioconjugatable quenchers (including water-soluble analogues) has been synthesized. Several synthetic routes have been developed for the rapid and effective access to new protease-sensitive "activatable" FRET-based probes. Some of them have been successfully applied to cellular molecular imaging assays. The major result of these works is probably the developement of two synthetic strategies to access to original heterotrifunctional molecular platforms for the simultaneous detection of two distinct protease activities. We expect that these tools could be highly useful for the early detection of some diseases as prostate cancer for which actual diagnosis technics based on detection/quantification of a single biomarker often lead to many false positive results
Книги з теми "Outils chimiques":
Christensen, Marianne. Technologie de l'ivoire au Paléolithique supérieur: Caractérisation physico-chimique du matériau et analyse fonctionnelle des outils de transformation. Oxford, England: J. and E. Hedges, 1999.
1950-, Malerba Franco, ed. Sectoral systems of innovation: Concepts, issues and analyses of six major sectors in Europe. Cambridge, UK: Cambridge University Press, 2004.
Musavu-Ndob, Aïchatou, André Lebert, and Malik Melas. Propriétés Physico-Chimiques des Aliments: Nouveaux Outils de Prédiction. ISTE Editions Ltd., 2015.
Dillmann, Philippe, and Ludovic Bellot-Gurlet, eds. Circulation et provenance des matériaux dans les sociétés anciennes. Editions des archives contemporaines, 2014. http://dx.doi.org/10.17184/eac.9782813001634.
Частини книг з теми "Outils chimiques":
THOMAS, Marc. "La matière première : les poudres et les fils métalliques." In La fabrication additive des alliages métalliques 1, 103–57. ISTE Group, 2022. http://dx.doi.org/10.51926/iste.9054.ch2.
Arimondo, Paola. "Chapitre 13 : Des outils chimiques pour reprogrammer les cellules tumorales." In Chimie et biologie de synthèse, 217–32. EDP Sciences, 2020. http://dx.doi.org/10.1051/978-2-7598-2316-1-016.
Arimondo, Paola. "Chapitre 13 : Des outils chimiques pour reprogrammer les cellules tumorales." In Chimie et biologie de synthèse, 217–32. EDP Sciences, 2020. http://dx.doi.org/10.1051/978-2-7598-2316-1.c016.
RIGNEAULT, Hervé, and Julien DUBOISSET. "Imagerie Raman cohérente." In Spectroscopies vibrationnelles, 273–88. Editions des archives contemporaines, 2020. http://dx.doi.org/10.17184/eac.4204.
Reiche, Ina, Aurélien Gourrier, and Jolanda Spadavecchia. "De l’analyse des ivoires archéologiques dorés à la synthèse archéo-inspirée des nanoparticules hybrides pour les applications biomédicales." In Regards croisés: quand les sciences archéologiques rencontrent l'innovation, 123–38. Editions des archives contemporaines, 2017. http://dx.doi.org/10.17184/eac.3793.