Статті в журналах: "Otis Library"

1

Bier, Lisa. "Deacon Otis' Library (review)." Libraries & the Cultural Record 38, no. 1 (2003): 81–82. http://dx.doi.org/10.1353/lac.2003.0005.

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2

Beasley, Gerald. "Curatorial Crossover: Building Library, Archives, and Museum Collections." RBM: A Journal of Rare Books, Manuscripts, and Cultural Heritage 8, no. 1 (March 1, 2007): 20–28. http://dx.doi.org/10.5860/rbm.8.1.272.

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I tend to associate the word “crossover” with popular music. I think of crossovers as being those artists whose music has successfully crossed over from a smaller market to a bigger one, like Mexican musicians making it big in the United States, or black musicians making it big with white audiences. And I frankly love the idea that I, as a librarian, might be able to make a curatorial crossover into a bigger market, much as Ricky Martin or Otis Redding made a musical crossover. Of course, I would have to address the two most common criticisms that are made . . .

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3

Allen, Susan M. "American Book Design and William Morris. Susan Otis Thompson." Library Quarterly 68, no. 1 (January 1998): 86–88. http://dx.doi.org/10.1086/602938.

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4

Giuntini, Parme, and Jean-Marie Venturini. "Learning by doing: using ePortfolios for assessment at Otis College of art and design." Library Hi Tech News 31, no. 7 (August 26, 2014): 11–15. http://dx.doi.org/10.1108/lhtn-06-2014-0047.

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Purpose – The purpose of this paper is to share best practices in using e-portfolios for assessment including a collaborative model between academic department and library. Design/methodology/approach – The authors collaborated to develop learning outcome rubrics that were then used by faculty and a team of reviewers to evaluate evidence collected in e-portfolios. Findings – E-portfolios provide a dynamic platform to centrally collect assessment material; however, effective evaluation of student evidence can be strengthened with collaboration between college departments. Research limitations/implications – This is a model that was sustainable and practical for a small art and design college. Practical implications – Other institutions working on assessment with limited personal resources may find this approach useful in addition to any institution considering how to use e-portfolios for collection and assessment of student work. Originality/value – Otis College of Art and Design has been using e-portfolios since 2008 and has been developing this model of assessment for sometime.

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Guo, Wei, Yun Fang, Weimei Pan, and Dekun Li. "Archives as a trusted third party in maintaining and preserving digital records in the cloud environment." Records Management Journal 26, no. 2 (July 18, 2016): 170–84. http://dx.doi.org/10.1108/rmj-07-2015-0028.

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Purpose This paper aims to present a case wherein a public archive intervenes in maintaining and preserving digital records (including underlying technological infrastructure) created by a private company to protect the trustworthiness of records, thereby helping the company to discharge their accountability. Design/methodology/approach This paper details the intervention of Tianjin Municipal Archives in the management of the records of Tianjin Otis Elevator Co., Ltd, the technical infrastructure that enables and supports such configuration, the issues encountered and the theoretical implications of this case. Findings This case suggests that not only does the concept of archives as a trusted third party remain relevant in the changing technological environment but also, in certain cases (e.g. wherein the supplier of evidentiary documents holds a monopoly over an industry), archives are becoming increasingly critical in maintaining the reliability and authenticity of digital records in the cloud environment. Research limitations/implications Given the challenges raised by the emerging cloud environment, it is vital to develop a renewed understanding of the concept of archives as a trusted third party, the relationship between archives and commercial third party services and the relationship between public archives and private records. Furthermore, this case identifies the need to re-examine archival methodologies to protect the authenticity of structured data. Originality/value This case exemplifies how archives can help private organizations address issues related to guaranteeing and demonstrating the evidential nature of digital records and provides empirical evidence for archives being conceptualized as a trusted third party in maintaining and preserving digital records.

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Cockayne, Sarah, Alison Pighills, Joy Adamson, Caroline Fairhurst, Shelley Crossland, Avril Drummond, Catherine E. Hewitt, et al. "Home environmental assessments and modification delivered by occupational therapists to reduce falls in people aged 65 years and over: the OTIS RCT." Health Technology Assessment 25, no. 46 (July 2021): 1–118. http://dx.doi.org/10.3310/hta25460.

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Background Falls and fall-related fractures are highly prevalent among older people and are a major contributor to morbidity and costs to individuals and society. Only one small pilot trial has evaluated the effectiveness of a home hazard assessment and environmental modification in the UK. This trial reported a reduction in falls as a secondary outcome, and no economic evaluation was undertaken. Therefore, the results need to be confirmed and a cost-effectiveness analysis needs to be undertaken. Objective To determine the clinical effectiveness and cost-effectiveness of a home hazard assessment and environmental modification delivered by occupational therapists for preventing falls among community-dwelling people aged ≥ 65 years who are at risk of falling, relative to usual care. Design This was a pragmatic, multicentre, modified cohort randomised controlled trial with an economic evaluation and a qualitative study. Setting Eight NHS trusts in primary and secondary care in England. Participants In total, 1331 participants were randomised (intervention group, n = 430; usual-care group, n = 901) via a secure, remote service. Blinding was not possible. Interventions All participants received a falls prevention leaflet and routine care from their general practitioner. The intervention group were additionally offered one home environmental assessment and modifications recommended or provided to identify and manage personal fall-related hazards, delivered by an occupational therapist. Main outcome measures The primary outcome was the number of falls per participant during the 12 months from randomisation. The secondary outcomes were the proportion of fallers and multiple fallers, time to fall, fear of falling, fracture rate, health-related quality of life and cost-effectiveness. Results The primary analysis included all 1331 randomised participants and indicated weak evidence of a difference in fall rate between the two groups, with an increase in the intervention group relative to usual care (adjusted incidence rate ratio 1.17, 95% confidence interval 0.99 to 1.38; p = 0.07). A similar proportion of participants in the intervention group (57.0%) and the usual-care group (56.2%) reported at least one fall over 12 months. There were no differences in any of the secondary outcomes. The base-case cost-effectiveness analysis from an NHS and Personal Social Services perspective found that, on average per participant, the intervention was associated with additional costs (£18.78, 95% confidence interval £16.33 to £21.24), but was less effective (mean quality-adjusted life-year loss –0.0042, 95% confidence interval –0.0041 to –0.0043). Sensitivity analyses demonstrated uncertainty in these findings. No serious, related adverse events were reported. The intervention was largely delivered as intended, but recommendations were followed to a varying degree. Limitations Outcome data were self-reported by participants, which may have led to inaccuracies in the reported falls data. Conclusions We found no evidence that an occupational therapist-delivered home assessment and modification reduced falls in this population of community-dwelling participants aged ≥ 65 years deemed at risk of falling. The intervention was more expensive and less effective than usual care, and therefore it does not provide a cost-effective alternative to usual care. Future work An evaluation of falls prevention advice in a higher-risk population, perhaps those previously hospitalised for a fall, or given by other professional staff could be justified. Trial registration Current Controlled Trials ISRCTN22202133. Funding This project was funded by the National Institute for Health Research (NIHR) Health Technology Assessment programme and will be published in full in Health Technology Assessment; Vol. 25, No. 46. See the NIHR Journals Library website for further project information.

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Smiljanić, Ilija, Dragana Ristanović, and Biljana Davidovski. "Revision and write-off of the monographic publications of the Public Library of Užice." Korak biblioteke: casopis za kulturu i bibliotecko-informacionu delatnost, no. 6 (2021): 173–91. http://dx.doi.org/10.5937/korbib2106173s.

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The process of the revision in libraries is defined by the Law on Library and Information Activities and the Rulebook on Inventory, Processing, Revision and Write-Off of Library and Information Materials and Sources. The revision of the fund in libraries on the one hand is a legal obligation and on the other hand gives a precise insight into the state of the fund, contributes to its relevance, opens such a valuable space for new publications. The paper presents the experiences gained during the work on the automated revision of the holdings of the Public Library of Užice in the new Cobiss environment. They can be use by libraries that will revision their funds in this way in the coming period. The aim of this paper is to offer ways to resolve dilemmas and doubts that may arise in certain phases of the automated revision process. Thanks to the benefits of the new Cobiss / Inventory environment, this revision is the most thorough to date and most accurately reflects the state of the fund.

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8

Oyekale, John O. "AN ASSESSMENT OF PROVISION, FUNCTIONALITY AND ACCESSIBILITY OF SCHOOL LIBRARIES IN PUBLIC SECONDARY SCHOOLS IN ODO-OTIN LOCAL GOVERNMENT AREA OF OSUN STATE, NIGERIA." Journal of Education and Practice 1, no. 1 (July 16, 2017): 35. http://dx.doi.org/10.47941/jep.178.

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Purpose: The purpose of the study was to investigate the provision, functionality and accessibility of School Libraries in public secondary schools in Odo-Otin Local Government Area of Osun State, Nigeria.Methodology: A qualitative research method was adopted. Evidence was gathered through semi-structured interviews with principals, staff members, teachers in charge of the library, as well as students in all the 17 public schools being investigated. A Local Inspector of Education was also interviewed at Okuku, the headquarters of the Local Government are, who gave further insight into the issues and challenges faced by public school libraries. Observations were made and recorded on a checklist as to how the libraries in schools visited were resourced and laid out. The checklist was created according to the resources one would expect to find in a well-resourced library as described in the literature. It was used to indicate the type of resources available in the library. No attempt was made to count the number of resources that were available; it was only used to determine if the resource was present. All the seventeen (17) public secondary schools in Local Government were visited and data was collected over a period of one month in 2017. Data collected was analysed using frequency counts and simple percentages. The findings were presented tabulated according to the research objectives.Findings: The study revealed that school libraries are not provided in most schools in Odo-Otin Local Government Area. It also revealed that the few libraries that existed are majorly housed in converted classrooms, with no certified professional staff, inadequate furniture, and grossly inadequate information resources; and that accessibility to the few libraries that exist depends on the staff members that equally use them as their staff rooms. It also revealed that two schools in the Odo-Otin had benefited from Federal Government of Nigeria’s SchoolUnique contribution to theory, practice and policy: The study revealed that a tier of Government in the Country is not fully implementing the National Policy on Education (2004); and that the learning environment in public secondary schools in Odo-otin is breach of Nigeria constitution on right to quality education.

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9

Jolene, Kate. "The Influence of Online Travel Agencies (OTAs) on Hotel Revenue and Distribution Strategies." Journal of Modern Hospitality 2, no. 1 (December 4, 2023): 14–25. http://dx.doi.org/10.47941/jmh.1557.

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Purpose: The main objective of this study was to explore the influence of Online Travel Agencies (OTAs) on hotel revenue and distribution strategies. Methodology: The study adopted a desktop research methodology. Desk research refers to secondary data or that which can be collected without fieldwork. Desk research is basically involved in collecting data from existing resources hence it is often considered a low cost technique as compared to field research, as the main cost is involved in executive’s time, telephone charges and directories. Thus, the study relied on already published studies, reports and statistics. This secondary data was easily accessed through the online journals and library. Findings: The findings revealed that there exists a contextual and methodological gap relating to the influence of Online Travel Agencies (OTAs) on hotel revenue and distribution strategies. Preliminary empirical review revealed that as the digital landscape continues to evolve, hotels must adapt their strategies to harness the benefits of OTAs while effectively managing the challenges. The findings of this research will benefit hoteliers, industry regulators, policymakers, and researchers by providing valuable insights into navigating the evolving landscape of hotel distribution and revenue management in the digital age. Unique Contribution to Theory, Practice and Policy: The Agency theory, Transaction Cost theory and the Resource Based View (RBV) theory may be used to anchor future studies relating to Online Travel Agencies (OTA). The study recommended diversification of distribution channels, negotiation of favorable contracts with OTAs, leveraging guest data for personalization, investing in direct booking campaigns and monitoring and adaption to market trends.

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10

Centurelli, Francesco, Riccardo Della Sala, and Giuseppe Scotti. "A Standard-Cell-Based CMFB for Fully Synthesizable OTAs." Journal of Low Power Electronics and Applications 12, no. 2 (May 5, 2022): 27. http://dx.doi.org/10.3390/jlpea12020027.

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In this paper, we propose a fully standard-cell-based common-mode feedback (CMFB) loop with an explicit voltage reference to improve the CMRR of pseudo-differential standard-cell-based amplifiers and to stabilize the dc output voltage. This latter feature allows robust biasing of operational transconductance amplifiers (OTAs) based on a cascade of such stages. A detailed analysis of the CMFB is reported to both provide insight into circuit behavior and to derive useful design guidelines. The proposed CMFB is then exploited to build a fully standard-cell OTA suitable for automatic place and route. Simulation results referring to the standard-cell library of a commercial 130 nm CMOS process illustrated a differential gain of 28.3 dB with a gain-bandwidth product of 15.4 MHz when driving a 1.5 pF load capacitance. The OTA exhibits good robustness under PVT and mismatch variations and achieves state-of-the-art FOMs also thanks to the limited area footprint.

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11

Jayachandran, Remya, Dhanaraj Jagalchandran, and Perinkolam Chidambaram Subramaniam. "Planar CMOS and multigate transistors based wide-band OTA buffer amplifiers for heavy resistance load." Facta universitatis - series: Electronics and Energetics 35, no. 1 (2022): 13–28. http://dx.doi.org/10.2298/fuee2201013j.

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Analog buffer amplifier configurations capable of driving heavy resistive load using different operational transconductance amplifier (OTA) are presented in this paper. The OTA CMOS buffer configurations are designed using 0.18 ?m SCL technology library in Cadence Virtuoso tool and multigate transistor OTA buffer in TCAD Sentaurus tool. CMOS OTA buffer configuration using simple OTA outperform the OTA buffer circuits using other OTAs in terms of power dissipation and stability. Measured results show that the OTA buffer circuit works well for resistive load below 100 ?. The gain tuning of up to 5 V/V is achieved with RL equal to 50 ?, output swing of 1 V. OTA buffer configuration implemented using multigate transistor with resistive load below 1 k? exhibits a bandwidth around 5 GHz and tunable gain up to 5 V/V.

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12

Ibrahimova, Z. "БІБЛІОТЕКА В СОЦІОКУЛЬТУРНОМУ ПРОСТОРІ ПОЛІЕТНІЧНИХ ОТГ: ДО КОНЦЕПТУАЛІЗАЦІЇ СОЦІОЛОГІЧНОГО ДОСЛІДЖЕННЯ". State and Regions. Series: Social Communications, № 4(44) (5 лютого 2021): 133. http://dx.doi.org/10.32840/cpu2219-8741/2020.4(44).19.

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The aim of the work is a sociological analysis of the problems and factors of library development in the socio-cultural space of the region to establish the actual needs of ethnocultural groups of the population in the services of the library system.Research methodology. During the study, the following methods were used: descriptive, analysis, synthesis, structural. Based on an examination of Ukrainian and international practices of introducing development models and positioning the best experience of close cooperation between libraries and local communities by using the method of comparative analysis, factors influencing the functions of the library system, transforming its social role in society and the nature of interaction with various ethnocultural regional groups have been established.Results. The work provides a sociological interpretation of the library as a communication and sociocultural institution and a multifunctional information center for communication of modern communities, functions and guidelines for the development of the library system under the influence of sociocultural changes. The need for a sociological definition of the essential influence of external factors and the creation of appropriate models for the embodiment of modernization projects in the library practice of multi-ethnic regions of the country is stated.Novelty. The scientific novelty of the work lies in establishing the relationship between the regional specificity of the intercultural OTG and the state of library services for national groups of the population.Practical value. The research results can be used for comprehensive sociological research and the development of practical measures to activate local communities to advocate for cultural rights, as a means of developing constructive dialogue in multi-ethnic societies, to develop sociological criteria for studying the impact of reform and the creation of OTGs on the functions of the library system as a component of programs for the development of intercultural interaction in multinational regions.Key words: socio-cultural regional space, multinational community, library system, sociological interpretation, sociological research.

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13

Leray, Matthieu, and Nancy Knowlton. "Random sampling causes the low reproducibility of rare eukaryotic OTUs in Illumina COI metabarcoding." PeerJ 5 (March 22, 2017): e3006. http://dx.doi.org/10.7717/peerj.3006.

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DNA metabarcoding, the PCR-based profiling of natural communities, is becoming the method of choice for biodiversity monitoring because it circumvents some of the limitations inherent to traditional ecological surveys. However, potential sources of bias that can affect the reproducibility of this method remain to be quantified. The interpretation of differences in patterns of sequence abundance and the ecological relevance of rare sequences remain particularly uncertain. Here we used one artificial mock community to explore the significance of abundance patterns and disentangle the effects of two potential biases on data reproducibility: indexed PCR primers and random sampling during Illumina MiSeq sequencing. We amplified a short fragment of the mitochondrial Cytochrome c Oxidase Subunit I (COI) for a single mock sample containing equimolar amounts of total genomic DNA from 34 marine invertebrates belonging to six phyla. We used seven indexed broad-range primers and sequenced the resulting library on two consecutive Illumina MiSeq runs. The total number of Operational Taxonomic Units (OTUs) was ∼4 times higher than expected based on the composition of the mock sample. Moreover, the total number of reads for the 34 components of the mock sample differed by up to three orders of magnitude. However, 79 out of 86 of the unexpected OTUs were represented by <10 sequences that did not appear consistently across replicates. Our data suggest that random sampling of rare OTUs (e.g., small associated fauna such as parasites) accounted for most of variation in OTU presence–absence, whereas biases associated with indexed PCRs accounted for a larger amount of variation in relative abundance patterns. These results suggest that random sampling during sequencing leads to the low reproducibility of rare OTUs. We suggest that the strategy for handling rare OTUs should depend on the objectives of the study. Systematic removal of rare OTUs may avoid inflating diversity based on commonβdescriptors but will exclude positive records of taxa that are functionally important. Our results further reinforce the need for technical replicates (parallel PCR and sequencing from the same sample) in metabarcoding experimental designs. Data reproducibility should be determined empirically as it will depend upon the sequencing depth, the type of sample, the sequence analysis pipeline, and the number of replicates. Moreover, estimating relative biomasses or abundances based on read counts remains elusive at the OTU level.

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14

Vize, P. D., A. Vaughan, and P. Krieg. "Expression of the N-myc proto-oncogene during the early development of Xenopus laevis." Development 110, no. 3 (November 1, 1990): 885–96. http://dx.doi.org/10.1242/dev.110.3.885.

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The N-myc proto-oncogene is expressed in a wide range of tissues during mammalian embryogenesis. This observation, along with the oncogenic capacity of this gene, has led to the suggestion that N-myc plays an important role in early development. However, due to the complexity of the expression pattern and the difficulty of manipulating mammalian embryos, little progress has been made towards understanding the developmental function of this gene. To enable a more detailed analysis of the role of this gene in early development, a study of the Xenopus homologue of N-myc was undertaken. Xenopus N-myc cDNA clones were isolated from a neurula library using a murine N-myc probe. Analysis of the timing of expression of N-myc mRNA and of the distribution of N-myc protein during Xenopus development indicate that this gene may be playing an important role in the formation of a number of embryonic structures, including the nervous system. N-myc is initially expressed as a maternal RNA, but this mRNA is degraded by the gastrula stage of development. Zygotic expression does not commence until late neurula. Examination of the distribution of the N-myc protein by whole-mount immunohistochemistry indicates that the early embryonic expression occurs in the central nervous system, the neural crest, the somites and the epidermis. Later expression is mostly within the head and somites. Specific structures within the head that express the protein include the eye, otic vesicle, fore and hindbrain and a number of cranial nerves. The results demonstrate that while N-myc is expressed in the developing nervous system of Xenopus, the timing of expression indicates that it is unlikely to be involved in regulation of the very first stages of neurogenesis.

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Fuentes-Soriano, Sara, Lara Prihodko, Mitchell Manford, and Zachary Rogers. "Shining a New Light on Elmer Ottis Wooton’s Legacy Herbarium and Historical Archive: an Exercise to Increase Student Participation while Promoting Public Engagement." Biodiversity Information Science and Standards 2 (June 13, 2018): e25783. http://dx.doi.org/10.3897/biss.2.25783.

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Elmer Ottis Wooton (1865–1945) was one of the most important early botanists to work in the Southwestern United States, contributing a great deal of natural history knowledge and botanical research on the flora of New Mexico that shaped many naturalists and scientists for generations. The extensive Wooton legacy includes herbarium collections that he and his famous student Paul Carpenter Standley (1884–1963), prolific botanist and explorer, used for the first Flora of New Mexico by Wooten and Standley 1915 , along with resources covering botany and range management strategies for the northern Chihuahuan Desert, and an extensive, yet to be digitized, historical archive of correspondence, field notes, vegetation sketches, photographs, and lantern slides, all from his travels and field work in the region. Starting in 1890, the most complete set of Wooton’s herbarium collections were deposited in the NMC herbarium at New Mexico State University (NMSU), and his archives, now stored in a Campus library, have together been underutilized, offline resources. The goals of this ongoing project are to secure, preserve, and promote Wooton’s important historical resources, by fleshing out the botanical history of the region, raising appreciation of herbarium collections within the community, and emphasizing their unique role in facilitating contemporary research aimed at addressing pressing scientific questions such as vegetation responses to global climate change. Students and the general public involved in this project are engaged through hands-on activities including cataloging, databasing and digitization of nearly 10,000 herbarium specimens and Wooton’s archives. These outputs, combined with contemporary data collection and computational biology techniques from an ecological perspective, are being used to document vegetation changes in iconic, climate-sensitive, high-elevation mountainous ecosystems present in southwestern New Mexico. In a later phase of the project, a variety of public audiences will participate through interactive online story maps and citizen science programs such as iNaturalist, Notes from Nature, and BioBlitz. Images of herbarium specimens will be shared via an online database and other relevant biodiversity portals (Symbiota, iDigBio, JStor) Community members reached through this project will be better-informed citizens, who may go on to become new stewards of natural history collections, with the potential to influence policies safeguarding the future of our planet’s biodiversity. More locally, the project will support the management of Organ Mountains Desert Peaks National Monument, which was established in 2014 to protect the area's human and environmental resources, and for which knowledge and data are currently limited.

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Budde, T. R. "SENECA, De otio; De brevitate vitae, ed. G. D. WILLIAMS. Pp. xiii + 271 (Cambridge Greek and Latin Classics). Cambridge, New York, Oakleigh: Cambridge University Press, 2003. Hardbound 47.50 (ISBN 0 521 58223 7); paperbound 16.95 (0 521 58806 5)." Notes and Queries 52, no. 4 (December 1, 2005): 513–14. http://dx.doi.org/10.1093/notesj/gji444.

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17

Dubey, Tanmay, and Vijaya Bhadauria. "Linearity Improvement of Bulk Driven Floating Gate OTA Using Cross-Bulk and Quasi-Bulk Techniques." Journal of Circuits, Systems and Computers, November 12, 2020, 2150124. http://dx.doi.org/10.1142/s0218126621501243.

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In this paper, two highly linear OTAs are presented using a combination of three linearization techniques: floating gate, bulk driven, and source degeneration. In the first OTA, bulk driven floating gate MOSFETs are used as input transistors. The input signal given at the bulk terminals of these input transistors are in the opposite phase of the input signal provided to one of the gates of the respective floating gate MOSFET. This cross-coupling method resulted in a highly linear voltage-to-current conversion at the cost of reduced transconductance. In the second proposed OTA, this reduction in transconductance is restored by using novel quasi-bulk floating gate MOSFETs as input transistors while maintaining the improved linearity. Both the OTAs are designed and simulated using 180 nm CMOS design library and powered with [Formula: see text]0.5[Formula: see text]V dual power supply. The process variation and mismatch effects on both the OTAs are examined using corner and Monte Carlo analysis. The layouts of the proposed OTAs are also presented and workability is confirmed using post-layout simulations.

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18

Fan, Sijia, Jinlong Jiang, Huan Zhang, Cuihong Wang, Shang Kong, Tingting Zhao, Ling Meng, et al. "Identification of HDAC inhibitors as neutrophil recruitment modulators in zebrafish using a chemical library screen." Disease Models & Mechanisms, September 20, 2023. http://dx.doi.org/10.1242/dmm.050056.

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Tissue injury-induced neutrophil recruitment is a prerequisite for the initiation and amplification of inflammatory responses. Although multiple proteases and post-translational modification (PTM) enzymes regulate leukocyte recruitment, an unbiased functional screen of those enzymes regulating inflammatory leukocyte recruitment has yet to be undertaken. Here, using a zebrafish tail fin amputation (TFA) model to screen a chemical library consisting of 295 compounds that target proteases and PTM enzymes, we identified multiple histone deacetylase (HDAC) inhibitors that modulate inflammatory neutrophil recruitment. AR-42, a pan-HDAC inhibitor, was shown to inhibit neutrophil recruitment in three different zebrafish sterile tissue injury models: TFA, copper-induced neuromasts damage (CIND), and mechanical otic vesicle injury (MOVI), and a sterile murine peritonitis model. RNA sequencing analysis of AR-42-treated fish embryos revealed downregulation of neutrophil-associated cytokines/chemokines, and exogenous supplementation with recombinant human IL-1β and CXCL8 partially restored the defective neutrophil recruitment in AR-42-treated MOVI model fish embryos. We thus demonstrate that AR-42 non-cell autonomously modulates neutrophil recruitment by suppressing transcriptional expression of cytokines/chemokines, thereby identifying AR-42 as a promising anti-inflammatory drug for treating sterile tissue injury-associated diseases.

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Hollis, Helena, Marina Rachitskiy, and Leslie Van der Leer. "The development and face validity testing of the Open Test of Information Literacy with context-specific add-ons: OTIL." LIBER Quarterly 29, no. 1 (February 18, 2019). http://dx.doi.org/10.18352/lq.10264.

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20

Li, Tiantian, and Zhangxiang Zhu. "A meta-analysis of online travel booking services adoption: the moderating effects of national or regional economic development level and culture differences." Aslib Journal of Information Management, November 24, 2022. http://dx.doi.org/10.1108/ajim-04-2022-0198.

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PurposeThis study aims to provide a systematic review and meta-analysis to explore the strength of the path relationship in the proposed model for online travel booking service adoption. It also explores the moderating effect of national or regional economic development levels and cultural differences.Design/methodology/approachA meta-analysis was conducted on the factors correlated with users' intention to adopt online travel booking services (OTBS) and the moderating effects of economic development levels and culture based on 42 empirical studies.FindingsPerceived usefulness, perceived ease of use, attitude and perceived behavioral control have a significant positive impact on adoption intention. By contrast, subjective norms have a significantly negative impact on adoption intention. Furthermore, the economic development level of a country or region significantly moderates the relationships between perceived usefulness and perceived behavior control, attitude and perceived behavior control, and subjective norms and adoption intention. At the same time, national or regional cultural differences significantly moderate the relationships between attitudes and adoption intention, perceived usefulness and perceived behavior control, and subjective norms and adoption intention.Originality/valueThis study was conducted to obtain a unified conclusion regarding the research field of online travel booking service adoption. Its content was original. The conclusion provides theoretical references for follow-up research and the development of targeted marketing programs for online travel-booking service providers.

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Cabrera Aldaya, Alejandro, and Billy Bob Brumley. "Online Template Attacks: Revisited." IACR Transactions on Cryptographic Hardware and Embedded Systems, July 9, 2021, 28–59. http://dx.doi.org/10.46586/tches.v2021.i3.28-59.

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An online template attack (OTA) is a powerful technique previously used to attack elliptic curve scalar multiplication algorithms. This attack has only been analyzed in the realm of power consumption and EM side channels, where the signals leak related to the value being processed. However, microarchitecture signals have no such feature, invalidating some assumptions from previous OTA works.In this paper, we revisit previous OTA descriptions, proposing a generic framework and evaluation metrics for any side-channel signal. Our analysis reveals OTA features not previously considered, increasing its application scenarios and requiring a fresh countermeasure analysis to prevent it.In this regard, we demonstrate that OTAs can work in the backward direction, allowing to mount an augmented projective coordinates attack with respect to the proposal by Naccache, Smart and Stern (Eurocrypt 2004). This demonstrates that randomizing the initial targeted algorithm state does not prevent the attack as believed in previous works.We analyze three libraries libgcrypt, mbedTLS, and wolfSSL using two microarchitecture side channels. For the libgcrypt case, we target its EdDSA implementation using Curve25519 twist curve. We obtain similar results for mbedTLS and wolfSSL with curve secp256r1. For each library, we execute extensive attack instances that are able to recover the complete scalar in all cases using a single trace.This work demonstrates that microarchitecture online template attacks are also very powerful in this scenario, recovering secret information without knowing a leakage model. This highlights the importance of developing secure-by-default implementations, instead of fix-on-demand ones.

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Drønen, K., I. Roalkvam, K. Tungland, H. Dahle, H. Nilsen, A. B. Olsen, and H. Wergeland. "How to define fish pathogen relatives from a 16S rRNA sequence library and Pearson correlation analysis between defined OTUs from the library: Supplementary data to the research article “Presence and habitats of bacterial fish pathogen relatives in a marine salmon post-smolt RAS”." Data in Brief, December 2022, 108846. http://dx.doi.org/10.1016/j.dib.2022.108846.

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Rezapour, Mostafa, Stephen J. Walker, David A. Ornelles, Patrick M. McNutt, Anthony Atala, and Metin Nafi Gurcan. "Analysis of gene expression dynamics and differential expression in viral infections using generalized linear models and quasi-likelihood methods." Frontiers in Microbiology 15 (April 9, 2024). http://dx.doi.org/10.3389/fmicb.2024.1342328.

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IntroductionOur study undertakes a detailed exploration of gene expression dynamics within human lung organ tissue equivalents (OTEs) in response to Influenza A virus (IAV), Human metapneumovirus (MPV), and Parainfluenza virus type 3 (PIV3) infections. Through the analysis of RNA-Seq data from 19,671 genes, we aim to identify differentially expressed genes under various infection conditions, elucidating the complexities of virus-host interactions.MethodsWe employ Generalized Linear Models (GLMs) with Quasi-Likelihood (QL) F-tests (GLMQL) and introduce the novel Magnitude-Altitude Score (MAS) and Relaxed Magnitude-Altitude Score (RMAS) algorithms to navigate the intricate landscape of RNA-Seq data. This approach facilitates the precise identification of potential biomarkers, highlighting the host’s reliance on innate immune mechanisms. Our comprehensive methodological framework includes RNA extraction, library preparation, sequencing, and Gene Ontology (GO) enrichment analysis to interpret the biological significance of our findings.ResultsThe differential expression analysis unveils significant changes in gene expression triggered by IAV, MPV, and PIV3 infections. The MAS and RMAS algorithms enable focused identification of biomarkers, revealing a consistent activation of interferon-stimulated genes (e.g., IFIT1, IFIT2, IFIT3, OAS1) across all viruses. Our GO analysis provides deep insights into the host’s defense mechanisms and viral strategies exploiting host cellular functions. Notably, changes in cellular structures, such as cilium assembly and mitochondrial ribosome assembly, indicate a strategic shift in cellular priorities. The precision of our methodology is validated by a 92% mean accuracy in classifying respiratory virus infections using multinomial logistic regression, demonstrating the superior efficacy of our approach over traditional methods.DiscussionThis study highlights the intricate interplay between viral infections and host gene expression, underscoring the need for targeted therapeutic interventions. The stability and reliability of the MAS/RMAS ranking method, even under stringent statistical corrections, and the critical importance of adequate sample size for biomarker reliability are significant findings. Our comprehensive analysis not only advances our understanding of the host’s response to viral infections but also sets a new benchmark for the identification of biomarkers, paving the way for the development of effective diagnostic and therapeutic strategies.

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"The Effectiveness of Pulsed Dye Laser in Management of Acne Vulgaris: A Systematic review and meta-analysis." American Journal of Dermatological Research and Reviews, 2021, 41. http://dx.doi.org/10.28933/ajodrr-2021-04-0205.

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Background: Acne vulgaris is one of the most prevalent skin diseases, affecting up to 85% of teenagers and young adults. Multiple treatment options including topical, systemic or physical therapies. However, the effects of conventional therapies are limited due to antibi-otic resistance and adverse effects such as irritation and teratogenicity of isotretinoin. Light-based therapy is an alternative and/or adjuvant therapy in patients who cannot tolerate or unresponsive to conventional therapies that may provide fewer side effects, patient com-fort, fast onset of action, and with equal or greater effectiveness. We aimed to assess the effectiveness of using Pulsed Dye Laser as a treatment option for acne vulgaris. A systemat-ic Review and Meta-analysis was peformed of randomized clinical trials assessing the ef-fectiveness of Pulsed Dye Laser in management of acne vulgaris. Methods: Medline Pubmed, Scopus, Cochrane library, the reference list, conference pro-ceedings, researchers in field of eligible studies were searched. Eight studies (n=275 sub-jects) were included in qualitative analysis of which six studies (n=190 subjects) were in-cluded in meta-analysis. The mean age of the participant was 21,94 years old. Intervention using application of Pulsed dye laser as monotherapy or combination in acne vulgaris pa-tients with follow-up at least 12 weeks. and the outcomes is a decrease mean of acne vul-garis lesions counts after received pulsed dye laser therapy. Results: Pooling of data using random effects model showed that the group that received PDL therapy alone or in combination had a lower number of acne lesions than the control group with the mean difference was -0.593 (95% CI = -1.290 to 0.104), the z value was -1.668 with p = 0.095. This shows that the number of lesions in the group that received sin-gle or combined PDL therapy was lower than the control group. However the difference is insignificant. Conclusion. From the results of the systematic review conducted, it can be concluded that in the group given Pulsed Dye Laser therapy there was a decrease in the total number of acne vulgaris lesions compared to before treatment, and the decrease, which was indicated by the difference in the mean number of acne lesions, was significantly greater compared to the control who was only given placebo. Pulsed Dye Laser therapy can be an alternative treatment option for acne vulgaris in patients who are unresponsive to previous treatment or conditions where there are contraindications to systemic therapy.

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Monge, Gonzalo, Matías Otto-Yáñez, Nicole Norambuena, Verónica Martínez, Daniela Retamales, and Rodrigo Torres-Castro. "Safety of Hyperbaric Oxygenation Treatment and Evaluation of Associated Clinical Parameters: A Single-Institutional Prospective Cohort Study." International Journal of Translational Medical Research and Public Health 7, no. 1 (May 18, 2023). http://dx.doi.org/10.21106/ijtmrph.430.

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Background and Objective: Adverse events (AEs) associated with hyperbaric oxygen therapy (HBOT) are uncommon and typically not serious, being the most frequent otic/sinus barotrauma. The objective of this study is to analyze the safety of the HBOT at 1.45 atmosphere absolute (ATA) and compare it with reportsat the same and higher pressures of treatment. AE per session was 7.1% for total AE and 4.1% for overall barotrauma. AE was reported in 28.3% of patients (n=49), with barotrauma and non-barotrauma AE in 20.3% (n=35) and 8.1% (n=14). All barotrauma was recorded as subjective (100% of ear ache without eardrum damage, Teed scale=0). The frequency of total AE obtained in our study was statistically higher for 1.5, 2, and >2 ATA. Non-barotrauma AE was also higher; the frequency of total AE obtained in our study was statistically significant for 1.5, 2, and >2 ATA but objective barotrauma was not present, and it was significantly lower than previously reported (p < 0.001). A very slow rate of pressurizations (below 1 psi/min) was associated with ear pain (OR=3.32; 95 CI%, 1.32-8.35; p < 0.001). The AEs reported in this safety surveillance prospective study are minor, and no objective barotrauma was reported. HBOT at 1.45 ATA is a safe treatment, that can be performed with a portable light and a less expensive hyperbaric chamber. Methods: A total of 175 patients (68 male, 107 female) were included in this prospective study. All patients were treated with HBOT at our facility from December 2019 to August 2021. For the comparative analysis, reports from studies published from 2012 to 2021 in MEDLINE EMBASE, BIREME, Lilacs, Scielo, and the Cochrane library were used. Binary variables are described in percentages with a 95% confidence interval (95% CI). Inferential analysis was performed using a bivariate analysis by calculating odds ratio (OR) with 95% confidence intervals. Statistical analyses and sample size calculations were performed with Stata version 13.0 (College Station, TX, USA). Results: In this study, the AE per session was 7.1% for total AE and 4.1% for overall barotrauma. AE was reported in 28.3% of patients (n=49), with barotrauma and non-barotrauma AE in 20.3% (n=35) and 8.1% (n=14), respectively. All barotrauma was recorded as subjective (100% of ear ache without eardrum damage, Teed scale=0). The frequency of total AE obtained in our study was statistically higher for 1.5, 2, and >2 ATA. Non-barotrauma AE was also higher, but objective barotrauma was not present and was significantly lower than previously reported (p <0.001). A very slow rate of pressurizations (below 1psi/minute) was associated with ear pain (OR = 3.32; 95% CI, 1.32-8.35; p <0.001). Conclusion and Implications for Translation: In this study, the AE reported in this prospective safety surveillance study are minor, and no objective barotrauma was reported. The HBOT at 1.45 ATA is a safe treatment that can be performed with a portable lighter and a less expensive hyperbaric chamber. This study supports the hypothesis that hyperbaric oxygenation therapy at 1.45 ATA is a safe treatment, allowing for the spread and application of adjuvant treatment in different pathologies. Copyright © 2023 Monge-Martínez, et al. Published by Global Health and Education Projects, Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution License CC BY 4.0.

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