Дисертації з теми "Osteoporosic fractures"
Оформте джерело за APA, MLA, Chicago, Harvard та іншими стилями
Ознайомтеся з топ-50 дисертацій для дослідження на тему "Osteoporosic fractures".
Біля кожної праці в переліку літератури доступна кнопка «Додати до бібліографії». Скористайтеся нею – і ми автоматично оформимо бібліографічне посилання на обрану працю в потрібному вам стилі цитування: APA, MLA, «Гарвард», «Чикаго», «Ванкувер» тощо.
Також ви можете завантажити повний текст наукової публікації у форматі «.pdf» та прочитати онлайн анотацію до роботи, якщо відповідні параметри наявні в метаданих.
Переглядайте дисертації для різних дисциплін та оформлюйте правильно вашу бібліографію.
Kaptoge, Stephen Kipkemoi. "Epidemiology of risk factors for osteoporosis and osteoporotic fractures." Thesis, University of Cambridge, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.615203.
Повний текст джерелаBraz, Manuela Giuliani Marcondes Rocha. "Sequenciamento paralelo em larga escala de genes candidatos para fragilidade óssea em indivíduos com osteoporose grave, familiar ou idiopática." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/5/5135/tde-22102018-123623/.
Повний текст джерелаOsteoporosis is a highly prevalent disorder resulting in fragility fractures and incurring in great morbi-mortality and economic burden. In most cases, osteoporosis has a multifactorial etiology, with an estimated heritability of 50-85% attributable to a combination of several low-impact genetic variants. Rarely, cases of syndromic osteoporosis due to high-impact genetic defects are seen. It is therefore hypothesized that severe/idiopathic cases of otherwise inconspicuous osteoporosis may have a monoor oligogenic etiology due to genetic variants with an intermediate effect. During the past years, advances in molecular sequencing have revealed novel candidate genes for bone fragility, and have enabled simultaneous sequencing of multiple genes. In this context, the objectives of this research project were: 1) to identify candidate genes for bone fragility, as previously reported in association to Mendelian disorders with high impact on bone resistance, idiopathic or familial osteoporosis, and genome-wide association studies (GWAS) for bone mineral density and fragility fractures; and 2) to perform molecular analysis of these candidate genes in patients with severe, familial or idiopathic osteoporosis. Through a systematic review, 128 candidate genes were identified and included in a panel for massively parallel sequencing. Coding regions and 25-bp boundaries were captured and sequenced. Rare variants (allele frequency < 1%), with a predicted high impact on protein function were initially selected as variants of interest. Thirty-seven subjects (21 sporadic cases and 7 families) were included according to stringent criteria based on clinical and densitometric evaluation, excluding individuals with secondary osteoporosis. Males represented 54% of the cohort, median age at diagnosis was 44 years, and 84% of subjects had a history of fractures. Thirtythree variants of interest were identified initially. After familial segregation analysis, 5 variants were considered as benign in regard to bone fragility, resulting in 28 potentially pathogenic variants, all heterozygous, present in 71% of the cohort. Of these variants, 26 were nonsynonymous, there was one 9-bp deletion and one large deletion involving the only coding exon of candidate gene GPR68. An association of two or more variants in different genes was present in 21% of the cohort, including a young woman with severe osteoporosis and variants in WNT1, PLS3 and NOTCH2. Familial segregation in this case suggested an additive pathogenic effect of these variants. Twenty-five percent of potentially pathogenic variants were identified in well-established candidate genes (WNT1, PLS3, COL1A1, COL1A2), and 57% located to novel candidate genes initially identified by GWAS, such as NBR1 and GPR68, which have been previously associated to changes in bone remodeling in mouse models. These results support the involvement of GWAS genes in the pathophysyiology of osteoporosis, and indicate a prominent role for digenic/oligogenic interactions in cases of severe, familial or idiopathic osteoporosis. Recognition of new molecular pathways in the determination of bone fragility may lead to the development of new drugs, and the identification of pathogenic variants associated to osteoporosis may allow individualized clinical management of patients and their relatives
Ugarte, Corbalán Laura de 1988. "The regulatory roles of MicroRNAs in bone remodeling and osteoporosis." Doctoral thesis, Universitat Pompeu Fabra, 2016. http://hdl.handle.net/10803/565403.
Повний текст джерелаEn l’àmbit de l’estudi de l’òs, els microRNAs (miRNAs) han estat descrits com factors claus en la regulació de la formació, remodelatge i homeòstasis de l’ òs. La identificació de miRNAs implicats en la funció esquelètica és imprescindible pel desenvolupament de noves estratègies terapèutiques, basades en miRNAs, dirigides al tractament de malalties òssies. Com en el cas d’altres molècules reguladores, els miRNAs poden patir modificacions durant el desenvolupament de malalties humanes. En aquest sentit, hem identificat un grup de miRNAs amb una expressió alterada en l’òs osteoporòtic i hem demostrat la implicació funcional d’algun d’aquests miRNAs en la regulació de la formació òssia i els mecanismes pels quals es produiria l’osteoporosi. Alhora, també hem ofert una visió general dels miRNAs presents en el teixit ossi humà i en les cèl·lules òssies. També hem identificat variants genètiques dins de les seqüències de miRNAs expressats en osteoblasts, que han estat associades amb la densitat mineral òssia. A més a més, aquesta associació ha estat funcionalment demostrada en òs i osteoblasts. Aquest treball reflexa l’elevada complexitat que hi ha darrera del sistema regulador per miRNAs i obre nous camins per la recerca i la teràpia.
Tan, Boon-Kiang. "Non-invasive determinants of osteoporotic fracture risk." University of Western Australia. Centre for Musculoskeletal Studies, 2005. http://theses.library.uwa.edu.au/adt-WU2005.0125.
Повний текст джерелаTavares, Bruna Filipa Gonçalves. "Prevenção da osteoporose." Master's thesis, Universidade da Beira Interior, 2013. http://hdl.handle.net/10400.6/1408.
Повний текст джерелаIntroduction: The prevention of osteoporotic fractures involves the identification of the individuals with clinical risk factors for fracture, judicious performing of dual-energy x-ray absorptiometry (DXA), anti-osteoporotic treatment and patients’ follow-up. Created in 2008, validated for Portugal in 2012, the FRAX® tool (WHO Fracture Risk Assessment Tool) gives the 10-year probability of hip and major fracture, integrating multiple risk factors. The National Osteoporosis Foundation (NOF) determined two thresholds of high risk, ≥ 3% and ≥ 20% respectively, which indicates the treatment intervention of the OP, in USA. The adequacy of these thresholds has been the object of studies by other authors, but there aren’t any studies regarding the portuguese population. The main objective of this study was to determine the risk threshold, calculated using the FRAX® tool, which allows high sensitivity to identify individuals at high risk of hip fracture, in Portugal. Methods: From August to November 2012, a questionnaire and data collection from clinical process were performed to patients at least 50 years old, with nontraumatic hip fracture, admitted to the Orthopedics Service in Hospital Pêro da Covilhã, Hospital Sousa Martins and Hospital Amato Lusitano. The risk of hip fracture and the one of major fracture were calculated for each patient using the clinical FRAX® (without bone mineral density - BMD) measured for the Portuguese population. We analyzed the thresholds for risk FRAX® corresponding to a sensitivity of 95% and 80% for the incident hip fracture. Results: There were included 138 patients with non-traumatic hip fracture. The mean age was 83.5± 7.4 years (81.2% women). The most prevalent risk factors were: female gender, age over 65 years old, personal and parental history of fragility fracture and causes of secondary OP. 91.2% of patients had never performed DXA and 89.8% hadn’t previously made anti-osteoporotic treatment. The thresholds for high risk of hip fracture, by clinical FRAX®, with a sensitivity of 80% and 95% for the incident hip fracture were ≥5,5% and ≥3%, respectively. Conclusions: We identified appropriate thresholds at high risk for osteoporotic hip fracture, using FRAX® tool in the Portuguese population. These have an important application in clinical practice, as it allows a better identification of individuals at risk for careful selection of those who should perform DEXA and pharmacological treatment.
Castillón, Bernal Pablo. "Implementación de una unidad de trauma geriátrico." Doctoral thesis, Universitat Autònoma de Barcelona, 2020. http://hdl.handle.net/10803/670446.
Повний текст джерелаIntroducción En el año 1990 se produjeron 1,6 millones de fracturas de cadera en todo el mundo y se estima que esa cifra aumentará a 6 millones en el año 2050. En la Unión Europea se producen 600.000 fracturas de cadera al año, aproximadamente, con un coste global anual de 13.000 millones de Euros. La incidencia en España es de 517 casos por cada 100.000 habitantes y por año. La edad media de 82 años y un 78% de los pacientes son de sexo femenino. Los objetivos del tratamiento de la fractura de cadera son preservar la vida y conseguir una recuperación funcional que permita al paciente integrarse de nuevo en su medio habitual. Pero, en estos pacientes, la tasa de mortalidad se eleva durante el primer año de un 8,4% a un 36%. Al año de la fractura el 50% presentan dificultades para caminar, el 38-39% presentan dificultades para realizar transferencias y el 17-19% presentan dificultades para el aseo. Hasta un 90% de los pacientes presentan múltiples comorbilidades, entre las que la enfermedad pulmonar obstructiva crónica, la demencia, la hipertensión arterial, la patología cardiaca isquémica y la diabetes son las más comunes. Las características de estos pacientes, ancianos y con múltiples comorbilidades, hizo surgir la idea de proporcionarles una atención compartida entre cirujanos ortopédicos y geriatras. Esa idea inicial ha evolucionado a la tendencia actual de implementar unidades de ortogeriatría que integren un tratamiento multidisciplinar. En este modelo a geriatras y traumatólogos se suman también anestesistas, rehabilitadores, fisioterapeutas, enfermeras y nutricionistas, entre otros. Objetivos El objetivo principal de esta tesis doctoral es determinar la demora para intervención quirúrgica de los pacientes con fractura de fémur proximal tras la implementación de una unidad de ortogeriatría. Los objetivos secundarios son determinar el tiempo de estancia hospitalaria, la mortalidad intrahospitalaria y a los 30 días, y los reingresos que se producen por complicaciones médicas y traumatológicas. Material y métodos Durante el año 2013 (Junio-Diciembre), 2014 y 2015, ingresaron en nuestro servicio 534 fracturas de cadera, de forma consecutiva. Mientras que en los años 2011, 2012 y 2013 (Enero-Mayo), cuando todavía no existía la Unidad de Traumatología Geriátrica (UTG) ingresaron 501. Los datos recogidos prospectivamente en el segundo periodo, tras la implementación de la UTG, han sido comparados con los datos de los pacientes que ingresaron en el primer periodo. Resultados La demora media para ser intervenido quirúrgicamente previamente a la implementación de la UTG fue de 2,27 días (DE=2,35), mientras que posteriormente fue de 1,84 (DE=1,73). (p=0,0004). La estancia media previamente a la implementación de la UTG fue de 11,39 días (DE=9,05), mientras que posteriormente fue de 10,08 (DE=5,43). (p=0,0024). La mortalidad en los primeros 30 días tras la fractura de cadera, previamente a la implementación de la UTG fue del 7,7%, mientras que posteriormente fue del 4,8%. (p = 0,027). Conclusión La implementación de una unidad de ortogeriatría, para el tratamiento de los pacientes con fractura de fémur proximal, que incluye un conjunto de medidas entre las que destacan la introducción de circuitos rápidos de tratamiento, tratamiento multidisciplinar integrado y protocolos de rehabilitación temprana postoperatoria, ha permitido disminuir de 2,27 a 1,84 días el tiempo de demora medio para ser intervenido quirúrgicamente tras el ingreso. El tiempo de estancia hospitalaria se ha reducido en un tiempo medio de un día. La mortalidad de los pacientes a los 30 días se ha reducido en un 2,9%. Los reingresos por complicaciones médicas o quirúrgicas no se han incrementado.
Introduction In 1990, there were 1.6 million hip fractures worldwide. This number is expected to reach 6 million by 2050. In the European Union, osteoporosis causes approximately 600.000 hip fractures per year. The annual estimated economic burden for healthcare systems is 13.000 million Euros. The incidence of hip fractures in Spain is 517 cases per 100.000 inhabitants and year. The average age is 82 years and 78% are women. The goal of hip fracture treatment is to return the patient to preoperative levels of function, facilitating return to pre-fracture residence and supporting long-term wellbeing. Mortality rates in hip fracture patients rise from 8.4 to 36% in the first year after surgery. One year after the fracture, 50% have difficulties in walking, 38-39% are not able to transfer from a bed to a chair and 17-19% require aids for bathing and grooming. Up to 90% of patients have several comorbidities. Commonly, these include chronic obstructive pulmonary disease, dementia, high blood pressure, ischemic heart disease, and diabetes. Elderly patients with several comorbidities could benefit from shared care approaches provided by orthopedic surgeons and geriatricians. This cooperation has triggered the current trend of implementing orthogeriatric units that integrate multidisciplinary teams. In this model, several disciplines, besides surgeons and geriatricians, are involved in the care of the patients including anesthesiologists, physical therapists, nurses, and nutritionists. Objectives The main objective of this study is to determine the delay for surgical intervention of patients with proximal femur fracture after the implementation of an orthogeriatric unit. Secondary objectives are to determine the length of hospital stay, in-hospital and 30-day mortality, and readmissions resulting from medical and trauma complications. Material and methods During 2013 (June-December), 2014, and 2015, 534 consecutive hip fractures were treated in our hospital. While in 2011, 2012, and 2013 (January-May), before the orthogeriatric unit (OGU) was created, 501 hip fractures were treated. Data collected prospectively in the second period, after the implementation of the OGU, have been compared with the first period data. Results The mean delay to undergo surgery before the implementation of the OGU was 2.27 days (SD = 2.35), compared to 1.84 (SD = 1.73). (p = 0.0004) for the second period. The average in-hospital stay before the implementation of the OGU was 11.39 days (SD = 9.05), compared to 10.08 (SD = 5.43). (p = 0.0024) after the orthogeriatric model of care was established. 30-day mortality rate after hip fracture, before OGU implementation, was 7.7%, and 4.8% afterward. (p = 0.027). Conclusion The implementation of an orthogeriatric unit for the treatment of patients with a hip fracture which requires a series of measures including the introduction of fast treatment circuits, integrated multidisciplinary treatment, and early postoperative rehabilitation protocols, has allowed a decrease from 2.27 to 1.84 days in the average time to surgery after admission. The length of hospital stay was reduced by an average time of one day. 30-day mortality was reduced by 2.9%. Readmissions for medical or surgical complications did not increase.
Misra, Devyani. "Warfarin use and risk of osteoporotic fractures." Thesis, Boston University, 2012. https://hdl.handle.net/2144/21219.
Повний текст джерелаOBJECTIVE: Prior studies examining the association of warfarin use and osteoporotic fractures have found conflicting results and have had methodological problems, such as confounding by indication and confounding by duration of warfarin use. Thus, we studied the association of warfarin use with fractures at the hip, spine and wrist, among older men and women with atrial fibrillation recruited from the general population, using rigorous statistical tools to overcome challenges faced by prior studies. METHODS: We included men and women ≥65 years with incident atrial fibrillation, without history of fracture, followed between 2000-2010 from The Health Improvement Network (THIN). Long-term warfarin use was defined in two ways: 1) warfarin use ≥ 1year; 2) warfarin use ≥3 years. Non-use was defined as no use of warfarin over the follow-up period. Propensity scores (PS) for warfarin use were calculated using logistic regression with long-term use of warfarin as the dependent variable and age, sex, body mass index (BMI), history of multiple falls, deep venous thrombosis, pulmonary embolism, heart failure, neuropsychiatric impairment, hyperthyroidism, estrogen use, beta blockers, corticosteroids, bisphosphonates, smoking and alcoholism as independent variables. Each warfarin user was then matched by PS to a non-user by the “greedy matching” method. Incidence rates were calculated for warfarin users and non-users. The association between long-term warfarin use and risk of hip, spine and wrist fractures was evaluated using Cox-proportional hazards models. RESULTS: Incidence rates of hip fracture were 5.21 and 6.20 per 1000 person-years among subjects with warfarin use >1 (n=20,346) and >3 (n=11,238) years, respectively. The hazard ratios of hip fracture for warfarin use >1 and >3 years were 1.08 (95% CI 0.87, 1.35) and 1.13 (95% CI: 0.84, 1.5), respectively. Similar findings were observed between warfarin use and risk of spine or wrist fracture. CONCLUSIONS: Long-term use of warfarin among older adults with atrial fibrillation is not associated with increased risk of osteoporotic fractures and thus, does not necessitate additional surveillance or prophylaxis.
2031-01-01
Hillier, Sharon Lee. "Water fluoridation and osteoporotic hip fracture." Thesis, University of Southampton, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.264665.
Повний текст джерелаBorgström, Fredrik. "Health economics of osteoporosis /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-781-2/.
Повний текст джерелаGuedj, Emmanuel. "Les fractures du sacrum par insuffisance osseuse." Montpellier 1, 1995. http://www.theses.fr/1995MON11050.
Повний текст джерелаBastos-Silva, Yasmin 1990. "Correlação do risco de fratura osteoporótica em 10 anos calculado pelo FRAX com e sem densitometria em mulheres brasileiras na pós menopausa = Correlation between osteoporotic fracture risk in 10 years calculated by FRAX with and without bone densitometry in post menopause brazilian women." [s.n.], 2015. http://repositorio.unicamp.br/jspui/handle/REPOSIP/312826.
Повний текст джерелаDissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas
Made available in DSpace on 2018-08-27T21:42:31Z (GMT). No. of bitstreams: 1 Bastos-Silva_Yasmin_M.pdf: 1080942 bytes, checksum: 7599dbea7c337dddf84a74226180fc92 (MD5) Previous issue date: 2015
Resumo: O risco de fratura osteoporótica pode ser avaliado clinicamente baseado em fatores clínicos e pela densidade mineral óssea (DMO), entretanto esses parâmetros não são bons preditores do risco de fratura. Recentemente, o Brasil foi incluído no instrumento fracture risk assessment tool- FRAX-BRASIL, porém seu uso tem sido limitado na prática clínica. OBJETIVO: Avaliar o grau de concordância entre o risco de fratura em 10 anos calculado pelo FRAX-BRASIL com e sem densitometria em mulheres brasileiras na pós-menopausa. MÉTODO: Realizou-se um estudo de corte transversal no período de novembro de 2014 a fevereiro de 2015, com 402 mulheres em acompanhamento no Ambulatório de Menopausa do Hospital da Mulher Prof. Dr. José Aristodemo Pinotti em Campinas-SP. Foram incluídas mulheres com 40 anos ou mais, em amenorreia há pelo menos 12 meses e com exame de densitometria óssea prévio a qualquer tratamento medicamentoso para osteopenia ou osteoporose. As mulheres foram entrevistadas por um pesquisador durante a consulta de rotina, na qual foram coletadas informações sobre fatores de risco necessários para o questionário FRAX-BRASIL e dados da densitometria óssea. Os dados obtidos foram inseridos na plataforma online FRAX-BRASIL, em que foi calculado o risco para uma fratura maior e de quadril, utilizando-se somente os fatores de risco clínicos e o risco incluindo valores de DMO do colo do fêmur em g/cm2. ANÁLISE ESTATÍSTICA: Para análise do grau de concordância entre os riscos de fraturas com e sem densitometria óssea foi utilizado o coeficiente de correlação intraclasse (ICC). O Teste de Mann-whitney foi utilizado para comparação entre as médias do risco de fratura calculado com e sem DMO; para comparação entre as frequências de alto risco calculadas com e sem DMO foi utilizado o Teste de comparação entre duas proporções. Para análise da associação entre as variáveis clinico/demográficas e a variação do risco de fratura foi utilizada a análise de regressão linear. O nível de significância adotado foi <0,05. RESULTADOS: A probabilidade de fratura em 10 anos calculada pelo FRAX-BRASIL para fratura de quadril e para fratura maior somente pelos fatores de risco clínicos foi de 0,84% ±1,92 e 4,03% ±2,98 e com DMO foi de 0,83% ±1,76 e 4,05% ±2,98 respectivamente. O coeficiente de correlação intraclasse entre o FRAX-BRASIL com e sem DMO foi de 0,76 (IC95% 0,716-0,799) para uma fratura maior e de 0,644 (IC95% 0,583-0,698) para fratura de quadril. Ao avaliar as mulheres utilizando o FRAX com DMO 0,75% e 5,22% excederam os limiares de alto risco para fratura maior e de quadril, respectivamente. Sem o acréscimo da densidade óssea 1% e 11,44% apresentaram alto risco para fratura maior e de quadril, respectivamente. Dessa forma a recomendação de tratamento foi concordante entre o FRAX com e sem DMO em 99,75% dos casos de alto risco de fratura maior e de 93,78% para o quadril. Os fatores associados a menor variação FRAX com e sem foram maior idade, menor DMO, menor T-score e ausência de fratura previa tanto para fratura maior como para quadril. O menor IMC esteve associado a menor variação do FRAX apenas para fratura maior. CONCLUSÃO: O risco de fratura maior ou de quadril foi baixo na população estudada. O FRAX-BRASIL apresentou alta concordância para estimar o risco de fratura maior e concordância moderada para fratura de quadril apresentando uma estimativa de risco para fratura semelhante com ou sem DMO em nossa população
Abstract: The risk of osteoporotic fracture can be clinically evaluated based on clinical factors and by the bone mineral density (BMD), but these parameters are not good predictors of fracture risk. Recently, Brazil was included in the fracture risk assessment tool- FRAX-BRAZIL, but its use has been limited in clinical practice. GOAL: To evaluate the degree of correlation between the degree of correlation between the risk of fracture in 10 years calculated by FRAX-BRAZIL with and without densitometry in Brazilian postmenopausal women. METHODS: A cross-sectional study was conducted with 402 women followed up at the Menopause Ambulatory at the Women's Hospital Prof. Dr. José Aristodemo Pinotti in Campinas-SP. Women were included with 40 years or more in amenorrhea for at least 12 months and with bone densitometry exam prior to any drug treatment for osteopenia or osteoporosis. A researcher interviewed the women during a routine visit, where information about risk factors necessary for the FRAX-BRAZIL questionnaire and data of bone densitometry were collected. The collected data were inserted on the online platform FRAX-BRAZIL where the risk for major fractures and of the hip using only clinical risk factors and the risk including femoral neck BMD values in g / cm2. STATISTICAL ANALYSIS: To analyze the degree of correlation between the risk of fractures with and without bone densitometry was used the intraclass correlation coefficient (ICC). The Mann-Whitney test was used to compare the averages of fracture risk calculated with and without BMD; to compare the frequencies of high risk calculated with and without BMD was used the compare Test between two proportions. For analysis of the association between clinical / demographic variables and the change of the fracture risk was used linear regression analysis. The significance level was <0.05. RESULTS: The fracture probability calculated in 10 years by using the FRAX-BRAZIL for hip fracture and major fracture only by clinical risk factors was 0.84% ± 1.92 and 4.03 ± 2.98% and BMD was 0.83% ± 1.76 and 4.05 ± 2.98%, respectively. The intraclass correlation coefficient between the FRAX-BRAZIL with and without BMD was 0.76 (IC95% 0.716-0.799) for a major fracture and 0.644 (IC95% 0.583-0.698) for hip fracture. When evaluating women using FRAX with BMD 0.75% and 5.22% exceeded the high-risk thresholds for major and hip fracture, respectively. Without the increase of the bone density 1% and 11.44% presented high risk for major fractures and of hip, respectively. Then the treatment recommendation was consistent between the FRAX with and without BMD in 99.75% of cases of high risk of major fracture and 93.78% for the hip. Factors associated with less variation FRAX with and without were older, lower BMD, lower T-score, and no previous fracture both for major fracture as to hip fracture. The BMI was associated with lower variation in the FRAX only to major fracture. CONCLUSION: The risk of major fracture or of the hip was low in the study population. The FRAX-BRAZIL presented a high correlation to estimate the risk of major fractures and moderate agreement for hip fracture presenting a risk estimate for similar fracture with or without BMD in our population. The FRAX-BRAZIL presented a high correlation to estimate the risk of major fractures and moderate correlation for hip fracture presenting a risk estimate for similar fracture with or without BMD in our population
Mestrado
Fisiopatologia Ginecológica
Mestra em Ciências da Saúde
Windolf, Markus [Verfasser]. "Fracture fixation in osteoporotic bone / Markus Windolf." Ulm : Universität Ulm, 2014. http://d-nb.info/118442988X/34.
Повний текст джерелаGao, Xin. "Economic evaluation of three preventive drug therapies for osteoporotic fractures among women at different risk levels." Morgantown, W. Va. : [West Virginia University Libraries], 2001. http://etd.wvu.edu/templates/showETD.cfm?recnum=2045.
Повний текст джерелаTitle from document title page. Document formatted into pages; contains xi, 211 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references (p. 171-186).
Sousa, Cristina de Jesus. "An?lise do risco de fraturas ?sseas nas mulheres idosas por meio da ferramenta FRAX." Universidade Cat?lica de Bras?lia, 2018. https://bdtd.ucb.br:8443/jspui/handle/tede/2498.
Повний текст джерелаApproved for entry into archive by Sara Ribeiro (sara.ribeiro@ucb.br) on 2018-11-19T13:39:46Z (GMT) No. of bitstreams: 1 CristinadeJesusSousaDissertacaoParcial2018.pdf: 780979 bytes, checksum: d8b80ee196a8840b1efaee7d6dcb18f5 (MD5)
Made available in DSpace on 2018-11-19T13:39:46Z (GMT). No. of bitstreams: 1 CristinadeJesusSousaDissertacaoParcial2018.pdf: 780979 bytes, checksum: d8b80ee196a8840b1efaee7d6dcb18f5 (MD5) Previous issue date: 2018-07-30
This is a quantitative, cross-sectional and descriptive study whose general objective was to evaluate the bone quality of elderly women with more than 60 years of age attending a general gynecology clinic in the Distrito Federal, through the application of the FRAX Tool. The study site was a private general gynecological clinic and the sample consisted of 147 were elderly women (60 to 90 years). For the data collection, three instruments were used: a sociodemographic questionnaire, the FRAX tool and the FRAQ-Brazil instrument. Comparisons of proportions between two independent groups were performed using Fisher's exact test. Categorical variables were described with counts and proportions. Quantitative variables of normal and asymmetric distribution were described as mean ? standard deviation and median (interquartile range) respectively. Normality was assessed by visual inspection of histograms. The R software was used in the statistical analysis of data. All probabilities of significance are bilateral and values less than 0.05 are considered statistically significant. The results obtained are found in articles 1 and 2. The research allowed an intense literature review to contribute to an understanding of which factors limit the use of the FRAX Tool, and which groups of older people should be better and more carefully analyzed for orientation. We found a mean and high risk of osteoporotic fractures assessed by applying the FRAX tool in non-elderly patients by 0.3%, in elderly patients up to 79 years old was found in 3,7% and in 45,5% of the elderly women above of 80 years. It can be concluded that the FRAX tool, despite some limitations, is important for the early identification and screening of individuals at risk of fractures due to its simplicity of application, allowing early and safe therapeutic decision making. It was also concluded that there is a significant increase in the risk of osteoporotic fractures with advancing age.
Trata-se de um estudo quantitativo, transversal e descritivo cujo objetivo geral foi avaliar a qualidade da massa ?ssea de idosas com mais de 60 anos frequentadoras de uma cl?nica de ginecologia geral no Distrito Federal, por meio da aplica??o da Ferramenta FRAX. O local do estudo foi uma cl?nica particular de ginecol?gica geral e a amostra foi constitu?da 147 mulheres idosas (60 a 90 anos). Para a coleta de dados, utilizaram-se tr?s instrumentos: um question?rio sociodemogr?fico, a Ferramenta FRAX e o instrumento FRAQ-Brasil. Compara??es de propor??es entre dois grupos independentes foram efetuadas utilizando-se teste exato de Fisher. Vari?veis categ?ricas foram descritas com contagens e propor??es. Vari?veis quantitativas de distribui??o normal e assim?trica foram descritas como m?dia ? desvio padr?o e mediana (intervalo interquartil) respectivamente. Normalidade foi avaliada com a inspe??o visual de histogramas. O software R foi utilizado na an?lise estat?stica de dados. Todas as probabilidades de signific?ncia apresentadas s?o do tipo bilateral e valores menores que 0.05 considerados estatisticamente significantes. Os resultados obtidos encontram-se nos artigos 1 e 2. A pesquisa permitiu a realiza??o de uma intensa revis?o de literatura visando contribuir para uma compreens?o de quais fatores limitam o uso da Ferramenta FRAX, e quais grupos de idosos devem ser melhores e mais cuidadosamente analisados para a orienta??o. Encontrou-se m?dio e alto risco de fraturas osteopor?ticas avaliado atrav?s da aplica??o da Ferramenta FRAX nas pacientes idosas aos 79 anos o percentual encontrado foi de 3,7% e em 45,5% nas idosas acima dos 80 anos. Pode-se concluir que a Ferramenta FRAX, apesar de algumas limita??es, ? importante para a identifica??o precoce e o rastreamento de indiv?duos com risco de fraturas, devido ? sua simplicidade de aplica??o, permitindo uma tomada de decis?o terap?utica precoce e segura. Concluiuse tamb?m que h? um aumento importante do risco de fraturas osteopor?ticas com o avan?ar da idade.
Keen, Richard William. "Genetic epidemiology of postmenopausal osteoporosis." Thesis, King's College London (University of London), 2000. https://kclpure.kcl.ac.uk/portal/en/theses/genetic-epidemiology-of-postmenopausal-osteoporosis(15d66e32-f0bb-4b51-9e82-60646699d319).html.
Повний текст джерелаEkman, Anna. "Hips at risk osteoporosis and prevention of hip fractures." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2001. http://publications.uu.se/theses/91-554-4930-1/.
Повний текст джерелаRidzwan, Mohamad. "A computational orthopaedic biomechanics study of osteoporotic hip fractures." Thesis, Imperial College London, 2016. http://hdl.handle.net/10044/1/47971.
Повний текст джерелаHellström, Hans-Olov. "Bone and aluminium /." Uppsala : Acta Universitatis Upsaliensis : Universitetsbiblioteket [distributör], 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8181.
Повний текст джерелаHenderson, Simon Alan. "Exercise, diet and dynamic bone metabolism in osteoporosis." Thesis, Queen's University Belfast, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.336730.
Повний текст джерелаHerman, Elizabeth O'Brien. "The Use of Osteoporotic Medications Following a Fracture." VCU Scholars Compass, 2006. http://scholarscompass.vcu.edu/etd_retro/118.
Повний текст джерелаDodds, R. A. "Structural and metabolic studies on normal and pathological bone." Thesis, Brunel University, 1985. http://bura.brunel.ac.uk/handle/2438/4870.
Повний текст джерелаKorpelainen, R. (Raija). "Exercise and risk factors of osteoporotic fractures in elderly women." Doctoral thesis, University of Oulu, 2005. http://urn.fi/urn:isbn:9514278054.
Повний текст джерелаTuck, Stephen Paul. "The pathogenesis of osteoporosis and low trauma fractures in men." Thesis, University of Leeds, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.438492.
Повний текст джерелаStefani, Kelly Cristina. "Relação do polimorfismo do receptor P2X7 com a densidade mineral óssea: estudo em pacientes idosos com fraturas do tornozelo." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/5/5140/tde-28022019-100221/.
Повний текст джерелаThe purpose of this study was to determine whether a genetic variation in the P2X7 receptor gene is associated with reduced bone mineral density and the risk of osteoporosis in patients over 50 years of age with ankle fractures. A Level-1 diagnostic study was conducted. Patients over 50 years of age with ankle fractures who had undergone surgical treatment were divided into two groups following the result of a bone densitometry: a study group with osteopenia (bone mineral density T score between -1 and -2.5) or osteoporosis (bone mineral density T score <= -2.5) and the control group with normal values (bone mineral density T score >= -1). Exclusion criteria were alterations that led to secondary osteoporosis. Patients were genotyped for 15 nonsynonymous single nucleotide polymorphisms (SNPs) within the P2X7 receptor (numbered from 1 to 15) obtained from saliva. We evaluated 121 patients with ankle fractures, 56 being from the control group, and 65 from the study group. All patients were sedentary, did not take any medication for the treatment of osteoporosis, did not smoke, and had suffered a low-impact trauma. The grouped assessment of the SNP alterations showed that if a gene has three or more SNP variants (36.4% of the 121 patients), out of the 15 possibilities, it is altered with clinical repercussions related to the loss or gain of the function of the gene. In evaluating the SNP alterations individually, the results suggest that: SNPs 1,4,14, and 15 are loss of function variants; SNPs 5 and 10 are described as loss of function variants; however, they have no influence on our study population; SNPs 11 and 13 are loss of function variants and not gain of function function as is described in the literature; and SNP 12 was associated with a loss of function in our population. In conclusion, we showed that the functional polymorphisms in P2X7 are associated with Bone Mineral Density and the risk of ankle fractures. As limitations to our study, we can point out the fact that we focused mainly on nonsynonymous polymorphisms, which do not cover all the genetic variations in P2X7, and the small number of participants when compared to the world literature. On the other hand, a strength of our study is that it was the first to assess P2X7 in the Brazilian population, which is quite heterogeneous from the genetic point of view due to our miscegenation, as compared to other studies that evaluated the population of northern Europe, which is genetically more homogeneous. In conclusion, the SNP12 polymorphism in P2X7 is associated with Bone Mineral Density and the risk of ankle fractures
MELO, Verônica Maria Pinho Pessôa. "Fraturas em crianças e adolescentes atendidos em hospital de trauma do Recife: associação com uso prévio de glicocorticoides?" Universidade Federal de Pernambuco, 2016. https://repositorio.ufpe.br/handle/123456789/18519.
Повний текст джерелаMade available in DSpace on 2017-04-07T13:15:48Z (GMT). No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) Dissertação Mestrado Verônica Melo CCS.pdf: 1393412 bytes, checksum: ba56180c890511d0089ae952978dcc15 (MD5) Previous issue date: 2016-07-01
Introdução: o uso crônico de glicocorticoides é considerado a principal causa de osteoporose secundária e iatrogênica. Existem poucos estudos associando fraturas ao uso de glicocorticoides na faixa etária pediátrica. Eles poderiam ajudar na criação de abordagens preventivas e terapêuticas. Objetivos: avaliar se o uso de glicocorticoides, nos 12 meses precedentes, associou-se à ocorrência de fraturas em crianças e adolescentes; identificar a frequência de asma e outras doenças; comparar o perfil demográfico, o tipo de trauma, o índice de massa corpórea, a prática de exercício físico, a ingesta de leite e o tabagismo passivo domiciliar nos grupos com e sem fratura; verificar a frequência de deficiência de vitamina D. Métodos: no período de abril a outubro de 2015, um estudo tipo caso controle foi conduzido em crianças e adolescentes vitimadas por trauma, com e sem fratura, a partir da análise dos dados coletados. Resultados: foram estudados 104 pacientes, 50 com fratura e 54 com trauma, mas sem fratura. Ao todo, 80,4% eram meninos e 40,4% estavam na faixa etária de 10 a 14 anos. O uso prévio de glicocorticoides ocorreu em 15,4% do total, sem diferença estatisticamente significante entre os dois grupos. Entre 39 pacientes com fratura e que dosaram a vitamina D, 47,2% tinham níveis séricos < 30ng/ml. A prática de exercício físico associou-se a um aumento em 2,2 vezes no risco para fratura. Conclusões: este estudo não mostrou associação entre o uso prévio de glicocorticoides e a ocorrência de fraturas em crianças e adolescentes. A faixa etária de 10 a 14 anos, o trauma grave e o exercício físico associaram-se com um maior risco para fraturas. Cerca de metade de uma amostra dos pacientes com fratura apresentou níveis insuficientes/deficientes de vitamina D, mesmo em região tropical.
Introduction: Osteoporosis is not exclusive to older adults and manifests by fractures. Chronic glucocorticoid use is considered the main cause of secondary and iatrogenic osteoporosis. Few studies have related fractures to the use of glucocorticoids in children and adolescents. Such studies could be useful for the development of preventive and therapeutic strategies. Objectives: To assess whether glucocorticoid use in the past 12 months is associated with the occurrence of fractures in children and adolescents; to identify the frequency of asthma and other diseases; and to compare the demographic profile, type of trauma, body mass index, physical activity, milk intake, and household exposure to cigarette smoke of groups with and without fractures; to verify the frequency of vitamin D insufficiency/deficiency. Methods: A case-control study, conducted from April to October 2015, analyzed the data of trauma children and adolescents with and without fractures. Results: A total of 104 trauma patients were studied, 50 with and 54 without fractures. In all, 80.4% were males, and 40.4% were aged 10 to 14 years. Previous glucocorticoid use occurred in 15.4% of the sample, without significant difference between the groups. Of the 39 fracture patients with measured serum vitamin D levels, 47.2% had levels < 30ng/ml. Physical activity was associated with a 2.2-fold risk of fractures, but without significance in multivariate analysis. Conclusions: This study did not find an association between previous glucocorticoid use and the occurrence of fractures in children and adolescents. In 10- to 14-year-olds, severe trauma and physical activity were associated with higher risk of fractures. About half the fracture sample had insufficient/deficient vitamin D levels, despite residing in a tropical region.
Lujan, Marianella Anzola. "Incidência de osteoporose e prevalência de fraturas referidas por idosos do Município de São Paulo. Estudo SABE: Saúde, Bem-estar e Envelhecimento, 2000 e 2006." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/89/89131/tde-08032013-162155/.
Повний текст джерелаIntroduction: Osteoporosis (OP) is a disease characterized by bone fragility and increased risk of fractures. It is considered a public health problem worldwide. Epidemiological studies have found association between sociodemographic, lifestyle and anthropometrical variables and increased risk of OP and osteoporotic fractures. Objetive: To estimate incidence of self-reported OP, in 2006, and prevalence of fractures after the age of 60 year-old, on a sample of elderly individuals from the Município de São Paulo, and verify association between selected variables and outcome. Method: based on data from the SABE Study (health, well-being and aging) 2000 - 2006, which is an epidemiological prospective study of a probabilistic household sample of elderly population ((≥ 66 y), of both sexes, from São Paulo City, Brazil. Association between sociodemographic (sex, age, life in rural area for 5 year or more during childhood or adolescence, schooling, and race) lifestyle (reported food intake (milk and dairy products, eggs and legumes, meat, fish and poultry, fruit and vegetables), reported alcoholic beverages intake) and smoking habit; and anthropometrics\' variables, such as body mass index (BMI) and self-reported OP and fractures after the age of 60 year-old, in 2006. Rao & Scott Test was used to verify association between the categorical variables and outcome (p<0,05) as well as simple logistic regression (CI95%). Stata software, version 10.1, was used for statistical calculation. Results: There were 114 new cases of self-reported OP in 2006, and an incidence rate of 13,93/1000 persons-year (IC95%=11,60 - 16,87). In women the incidence rate was 22,95/1000 persons-year (CI95%: 19,08 - 27,87), and in men it was 3,34/1000 persons-year (IC95%: 1,85 - 6,73). Prevalence of self reported fractures after de age of 60 y was estimated in 17,16%. Female sex (OR= 7,69; p=0,000) and frequency of reported alcoholic beverages intake < 4 times/week (OR= 2,26; p=0,019), were risk factors for self-reported OP. Female sex (OR=2,38;p=0,000), advanced age (≥75 y) (OR=1,72; p=0,012), frequency of reported alcoholic beverages intake < 4 times/week (OR=2,45; p=0,016), self-reported OP in 2000 (OR=1,75; p=0,048), and self-reported OP in 2006 (OR=2,29; p=0,000), were risk factors for reporting fractures after the age of 60 years-old Conclusions: female sex, advanced age, were risk factors for reported OP and fractures after 60 y. Among modifiable variables, intake of alcoholic beverages as often as > 4 times/week was negatively associated with reported OP and fractures after the age of 60 y.
Hallberg, Inger. "Health-Related Quality of Life in Postmenopausal Women with Osteoporotic Fractures." Doctoral thesis, Linköpings universitet, Omvårdnad, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-51524.
Повний текст джерелаHartikka, H. (Heini). "Genetic factors in bone disorders:osteogenesis imperfecta, juvenile osteoporosis and stress fractures." Doctoral thesis, University of Oulu, 2005. http://urn.fi/urn:isbn:951427718X.
Повний текст джерелаHeijckmann, Anna Caroline. "Bone mass and fractures in patients at risk for secondary osteoporosis." Maastricht : Maastricht : University Press Maastricht ; University Library, Universiteit Maastricht [host], 2007. http://arno.unimaas.nl/show.cgi?fid=9701.
Повний текст джерелаLöfman, Owe. "Osteoporosis in women : epidemiological and diagnostic perspectives /." Linköping : Univ, 2002. http://www.bibl.liu.se/liupubl/disp/disp2002/med737s.pdf.
Повний текст джерелаVidal, Edison Iglesias de Oliveira. "Aspectos epidemiológicos das fraturas do fêmur proximal em idosos." [s.n.], 2010. http://repositorio.unicamp.br/jspui/handle/REPOSIP/308817.
Повний текст джерелаTese (doutorado) - Universidade Estadual de Campinas. Faculdade de Ciências Médicas
Made available in DSpace on 2018-08-16T10:58:46Z (GMT). No. of bitstreams: 1 Vidal_EdisonIglesiasdeOliveira_D.pdf: 5523772 bytes, checksum: 95d09fb9d160d1f4bfcc3cfe1b5a30d9 (MD5) Previous issue date: 2010
Resumo: As fraturas do fêmur proximal (FFP) correspondem a um importante problema de saúde pública em todo o mundo. Dentre todas as fraturas associadas à osteoporose são consideradas como as mais graves e correlacionam-se com os maiores índices de morbimortalidade, dependência funcional e custos para os indivíduos e os sistemas de saúde. O maior crescimento em sua incidência nos próximos anos é esperado nos países em desenvolvimento, todavia, estes também são os locais onde é maior a carência por dados acerca da epidemiologia dos pacientes acometidos por estas fraturas. A presente pesquisa teve como objetivo analisar alguns aspectos desta epidemiologia tanto no âmbito nacional como internacional. Como resultado foram confeccionados três artigos abordando esta temática. O primeiro artigo avaliou, a partir de uma base de dados de todas as hospitalizações por FFP na província de Quebec, no Canadá, a hipótese da equivalência do intervalo de tempo entre a fratura e a cirurgia e o intervalo entre a hospitalização e a cirurgia, enquanto preditores da ocorrência de óbito intra-hospitalar. Após controle para a presença de outras variáveis, nenhum dos intervalos mostrou associar-se com a mortalidade intra-hospitalar. Concluiu-se que, ao menos na medida em que a diferença entre os intervalos sejam pequenas como no caso observado, os mesmos podem ser utilizados de modo intercambiável sem comprometer a interpretação da associação entre o timing cirúrgico e a mortalidade intra-hospitalar, tal como pressuposto em diversos estudos prévios da literatura internacional. O segundo artigo buscou caracterizar o perfil clínico de idosos brasileiros hospitalizados em função de uma FFP, bem como os padrões de tratamento adotados, as complicações intra-hospitalares e a mortalidade ao longo de um ano. Dentre outros resultados de interesse, observou-se uma taxa de mortalidade em um ano de 13,4% (IC95%: 10,1 - 17,5%) e intervalos bastante elevados tanto entre a fratura e a hospitalização (média de 3,6 dias) como entre a internação e a cirurgia (média de 12,8 dias). O terceiro artigo procurou avaliar dentro do contexto brasileiro a associação entre o intervalo de tempo da fratura à cirurgia e a sobrevida dos idosos acomeditos por uma FFP. Após ajuste para variáveis de confundimento observou-se uma associação entre uma maior demora para a internação hospitalar e o óbito (HR: 1,08 , IC95%: 1,04 - 1,12, P < 0,001). Discute-se a questão das FFP enquanto objeto epidemiológico privilegiado, inclusive como um possível evento sentinela a ser monitorado no âmbito da saúde do idoso tanto no plano nacional como internacional.
Abstract: Hip Fractures (HF) represent the most severe of all osteoporotic fractures and remain an important cause of mortality, morbidity, dependency and costs for older adults and healthcare systems worldwide. Even though the greatest increase regarding the incidence of HF is expected to occur in the developing countries of the World, those are also the regions from where less information is available regarding the epidemiology of those fractures. The present research aimed to analyze selected aspects of the epidemiology of those fractures both in Brazil and internationally. Three manuscripts were produced as a direct result of this investigation. The first manuscript assessed the widely adopted assumption of interchangeability between the gap from hospital admission to surgical HF repair and the actual gap from fracture to surgery as predictors of in-hospital mortality among HF patients. A database encompassing all HF hospital admissions in Quebec, Canada, was the primary source of data for the analyses undertaken in this study. After statistical adjustment for the presence of other covariates neither of the time intervals to surgery was a significant predictor of in hospital mortality. As a conclusion, at least to the extent of the small differences observed between both gaps, they might be used interchangeably without compromising the interpretation of the relationship between surgical timing and in-hospital mortality, as assumed by previous studies. The second manuscript aimed to describe the clinical profile, treatment patterns, in hospital complications and one-year mortality of elderly Brazilians with an incident HF. Among other findings 13.4% (95%CI: 10.1% - 17.5%) of patients died during the first year and large gaps from fracture to hospital admission (mean 3.6 days) and from hospital admission to surgery (mean 12.8 days) were noted. The third manuscript examined in the context of a developing country the association between surgical timing and the survival of older adults after a HF. After adjusting for the presence of other covariates a small association between delayed hospital admission and reduced survival (HR: 1.08, 95% CI: 1.04 - 1.12) was observed. The point is made that HF should be considered a privileged epidemiological object, which might be used strategically as a sentinel event to be monitored both locally and internationally as a marker of the quality of health care to the elderly.
Doutorado
Epidemiologia
Doutor em Saude Coletiva
Fronza, Fernanda Cerveira Abuana Osório. "Avaliação prospectiva de um programa de exercícios aquáticos sobre parâmetros morfométricos vertebrais em mulheres na pós menopausa." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/39/39132/tde-28052012-155126/.
Повний текст джерелаNormal aging is a continuous process that results in biological and psychosocial changes, unaffected by pathologies. These changes can lead to a loss in neuromuscular and skeletal order, impacting the locomotors system in the elderly. Osteoporosis is a systemic disease that progressively affects the skeleton structure where the fractures its main consequence, mainly in the spine. The gauged of these fractures can be assessed by vertebral morphometry, by using X-ray (MRX) or X-ray absorptiometry (MXA), which consider the vertebra morphology trough comparison between the heights of its contours in 6 different points. The women, especially postmenopausal, are more susceptible to fractures. The exercise prescription should not just add physical benefits, but also consider the predisposition to the rise of new injuries, such as fractures. The high-intensity exercise in the water can act as a safety feature for a population usually weakened by age. The goal of this research was the investigation if a mechanical overload caused by a program of high-intensity water exercise is safe for the spine morphology in postmenopausal women. A prospective and controlled study was made where 108 postmenopausal sedentary women were distributed in a fracture group (n = 20) and one without fracture (n = 88). The group was distributed in control (CG) (n = 44) composed by sedentary elderly and intervention (GI) (n = 64), formed by those who participated in the protocol for water exercises. All participants received oral supplementation with 500 mg calcium and 1000 IU of Vitamin D3 and were submitted to an initial assessment and 24 weeks after intervention of water exercises. Were evaluated anthropometric data, information on ethnicity, pain parameters, neuromuscular tests applied to variables and performing bone densitometry followed by morphometry to identify fractures. The findings showed that 18.51% of the women present fracture, predominantly located in the anterior thoracic spine. Were observed significant changes for strength, flexibility and a reduction of fall´s in a group with and without fracture (p <0.05). The presence of fractures was associated with age, body mass index (BMI) and bone mineral content (BMC) of the femoral trochanter (p <0.0001). The performance variables have best scores in GI than GC, even in fractured women included in this group. The protocol used was safe for postmenopausal women
Mitchell, Sarah L. "Quadriceps function in elderly patients after proximal femoral fracture." Thesis, University of Glasgow, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.250054.
Повний текст джерелаMäättä, M. (Mikko). "Assessment of osteoporosis and fracture risk:axial transmission ultrasound and lifestyle-related risk factors." Doctoral thesis, Oulun yliopisto, 2013. http://urn.fi/urn:isbn:9789526200507.
Повний текст джерелаTiivistelmä Osteoporoottisiin lonkkamurtumiin liittyy korkean sairastavuuden ja kuolleisuuden lisäksi huomattavat taloudelliset kustannukset. Tässä työssä tutkittiin matalataajuisen ultraäänitekniikan soveltuvuutta osteoporoosin ja murtumariskin arviointiin. Matalataajuista luun pituusakselin suuntaista ultraäänitekniikkaa voidaan käyttää luun mineraalitiheyden ja rakenteen tutkimiseen. Lisäksi tutkittiin elintapoihin liittyviä lonkkamurtuman riskitekijöitä sekä näiden yhdistämistä ultraäänimittaustulosten kanssa riskimalliin. Tutkimuksessa käytettiin kahta tutkimuspopulaatiota. Ensimmäisen muodosti 1222 ikääntynyttä naista, joiden elintavat ja liikuntakyky kartoitettiin tutkimuksen alussa. Kolmentoista vuoden seuranta-ajan aikana tapahtuneet murtumat kerättiin potilasarkistoista. Osa naisista osallistui matalataajuisella aksiaalisuuntaisella ultraäänellä tehtyyn mittaukseen ja kaksienergiseen röntgentutkimukseen (DXA). Toinen tutkimuspopulaatio koostui 95 postmenopausaalisesta naisesta. Naisten murtumahistoria kerättiin ja heille tehtiin matalataajuinen ultraäänimittaus sekä DXA- ja perifeerinen tietokonetomografiatutkimus (pQCT). Alhainen painoindeksi ja heikentynyt liikuntakyky lisäsivät lonkkamurtuman riskiä. Vähäinen fyysinen aktiivisuus lisäsi ja kohtalainen kahvinjuonti ja verenpainetauti alensivat reisiluun kaulan murtumariskiä. Tupakointi ja korkea ikä kasvattivat sarvennoisen alueen lonkkamurtuman riskiä. Matalataajuisen ultraäänen nopeus oli yhteydessä reisiluun yläosan geometriaan ja mineraalitiheyteen. Alhainen ultraäänen nopeus oli merkittävä lonkkamurtuman riskitekijä sekä yksin että yhdistettynä elintapamuuttujiin. Lisäksi ultraäänimenetelmä saavutti röntgenmenetelmiin (DXA ja pQCT) verrattavan erottelukyvyn murtumapotilaiden ja kontrollihenkilöiden välillä. Tutkittu ultraäänimenetelmä osoittautui lupaavaksi työkaluksi luun karakterisoinnissa ja murtumariskin arvioinnissa. Laajempia seurantatutkimuksia tulosten vahvistamiseksi tarvitaan erityisesti elintapoihin liittyvien riskitekijöiden ja ultraäänen yhdistämisen osalta
Bidesi, Anup Singh. "Comparison of texture classification methods to evaluate spongy bone texture in osteoporosis /." free to MU campus, to others for purchase, 2004. http://wwwlib.umi.com/cr/mo/fullcit?p1422912.
Повний текст джерелаRazmkhah, Omid. "Effect of sideways impact fall on the osteoporosis fractures of proximal femur." Thesis, Kingston University, 2014. http://eprints.kingston.ac.uk/28910/.
Повний текст джерелаSmith, Matthew S. "Bone fracture toughness of estrogen deficient rabbits." Morgantown, W. Va. : [West Virginia University Libraries], 2003. http://etd.wvu.edu/templates/showETD.cfm?recnum=3094.
Повний текст джерелаTitle from document title page. Document formatted into pages; contains x, 100 p. : ill. (some col.). Includes abstract. Includes bibliographical references (p. 91-96).
Ferreira, Neville de Oliveira 1982. "Qualidade de vida de mulheres com osteoporose pos-menopausa : correlação entre o qualeffo 41 e SF-36." [s.n.], 2008. http://repositorio.unicamp.br/jspui/handle/REPOSIP/310477.
Повний текст джерелаDissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas
Made available in DSpace on 2018-08-11T15:10:52Z (GMT). No. of bitstreams: 1 Ferreira_NevilledeOliveira_M.pdf: 789783 bytes, checksum: 5dfd61c25cd1bdee8f3b7700bbb2088e (MD5) Previous issue date: 2008
Resumo: OBJETIVO: avaliar a qualidade de vida (QV) e fatores associados em mulheres com osteoporose pós-menopausa correlacionado QUALEFFO 41 com o SF-36. MÉTODOS: realizou-se um estudo de corte transversal com 220 mulheres pósmenopausa (idade entre 55-80 anos), sendo 110 com osteoporose e 110 sem osteoporose, pareadas por idade (± 3anos). Todas foram entrevistas para avaliação da QV realizada através de dois questionários: Quality of Life Questionary of European Foudation for Osteoporosis 41 (QUALEFFO 41) e o Short Form Health Survey 36 (SF-36). Para análise dos dados foi considerado um nível de significância de 5% (p<0,05). RESULTADOS: as características clínicas entre os grupos foram similares, com diferença estatisticamente significativa apenas em relação ao Índice de Massa Corpórea (IMC), raça, escolaridade, idade da menopausa e uso de Terapia Hormonal (TH) (p<0.001). Mulheres com osteoporose apresentaram pior QV tanto no QUALEFFO 41 quanto SF-36, para todos os domínios estudados sendo os dados ajustados para IMC, raça, escolaridade e uso de TH (p<0.001). Houve correlação significativa entre todos os domínios do QUALEFFO 41 com seus correspondentes do SF-36 (p<0.001) Os únicos fatores relacionados à pior QV foram IMC>25 e sedentarismo, já o trabalho remunerado esteve associado à melhor QV (IC=95%). CONCLUSÃO: Mulheres com osteoporose apresentam comprometimento da qualidade de vida particularmente nos aspectos físicos e psico-sociais. Os fatores associados à QV foram a obesidade, o sedentarismo e o trabalho remunerado. Palavras-chave: osteoporose, qualidade de vida, fratura vertebral, QUALEFFO 41, SF-36
Abstract: OBJECTIVE: To evaluate quality of life (QoL) and associated factors in women with postmenopausal osteoporosis, correlating QUALEFFO 41 with SF-36. METHODS: A cross-sectional study was conducted in 220 postmenopausal women (ages ranging from 55-80 years). Of the total number, 110 women had osteoporosis and 110 women did not have osteoporosis and these women were paired by age (± 3 years). Two questionnaires were administered to all subjects for evaluation of QoL: the Quality of Life Questionnaire of the European Foundation for Osteoporosis 41 (QUALEFFO 41) and the Short-Form Health Survey 36 (SF-36). For data analysis, a significance level of 5% was set (p<0.05). RESULTS: Clinical characteristics between the groups were similar, with statistically significant differences only in Body Mass Index (BMI), race, school education, age at menopause and use of Hormone Therapy (HT) (p<0.001). Women with osteoporosis had a worse QoL both in the QUALEFFO 41 and in the SF-36, in all domains studied. Data was adjusted for BMI, race, school education and use of HT (p<0.001). There was a significant correlation between all domains in the QUALEFFO 41 questionnaire and their corresponding domains in the SF-36 (p<0.001). The only factors related to worse QoL were BMI>25 and sedentary lifestyle. In contrast, paid work was associated with a better QoL (CI=95%). CONCLUSION: Women with osteoporosis had an impaired quality of life, especially relating to the physical, psychological and social aspects. The factors associated with QoL were obesity, sedentary lifestyle and paid work. Keywords: osteoporosis, quality of life, vertebral fracture, QUALEFFO 41, SF- 36
Mestrado
Ciencias Biomedicas
Mestre em Tocoginecologia
Pande, Ira. "Causes and consequences of hip fracture in men." Thesis, King's College London (University of London), 2000. https://kclpure.kcl.ac.uk/portal/en/theses/causes-and-consequences-of-hip-fracture-in-men(936ddf70-60c5-412c-8508-a12c9570ada7).html.
Повний текст джерелаEmerson, Karissa Mary. "Osteoporosis Treatment Based on Fracture Risk: A Quality of Care Study." Diss., North Dakota State University, 2018. https://hdl.handle.net/10365/27854.
Повний текст джерелаCarey, Shannon De Ann. "Development of an Evidence-Based Protocol for the Management of Acute Vertebral Fragility Fractures." ScholarWorks, 2017. https://scholarworks.waldenu.edu/dissertations/4049.
Повний текст джерелаNetto, Henrique de Barros Pinto. "Propriedades mecânicas de dois sistemas de osteossíntese empregando placa volar de rádio distal." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/17/17142/tde-17042018-152558/.
Повний текст джерелаEvaluating the biomechanical properties in two osteosynthesis systems using a volar distal radius plate by changing the type of screw used, whether locked or cortical, in the distal row of the plate, with or without bone grafting in Sawbone (TM) models. This is an experimental study of fractures of the extra articular distal radius, considered to be unstable, with two fragments and a dorsal wedge of 11 mm (AO 23 A3 classification), as well as the open-wedge osteotomy model frequently used by Orthopedic surgeons, in clinical practice. Ten left-hand radios bones, Sawbone (TM) (Code: 3407), validated for biomechanical studies were used. These were then divided into two groups of 5 bones each. The groups were submitted to two osteosynthesis systems: fixation system 1, VA-LCP left variable-angle volar plate, double-column, 6/3 holes, with four distal locked screws, two proximal locked screws and one proximal cortical screw. The fixation system 2 used the same volar plate, but only the four cortical screws were changed in the distal row. The models were submitted to mechanical tests of dorsal flexion of 30 N and axial compression of 250 N to evaluate the deflection and stiffness of the systems, changing the placement of the bone graft. Next, there was the cyclic loading test of 250 N per 1000 HZ, simulating a 6-week post-op. In the second part of the study, the same tests of axial compression and dorsal flexion were performed, using the same loading forces used in the first phase of the mechanical tests to evaluate the possible changes in deflection and stiffness. In order to compare the results between the dorsal flexion tests and axial compression before and after the cyclic loading, the Mann-Whitney U test was used, considering a level of significance of 5%. When analyzing the results obtained, the cortical screw fixation system with graft was shown to be more rigid, both in deflection and in compression when compared to the other fixation systems, especially with the locked system without graft. Regarding the clinical relevance of the study, the volar distal radius plate is commonly used in the treatments of distal radius fractures, however the ideal configuration of the distal screws has not yet been determined. The results of the fixation system with four cortical screws with bone graft, from a biomechanical point of view in vitro, proved to be a reliable form of treatment.
Hauksson, Gudjon. "Cost effectiveness of alendronate to reduce hip fractures from osteoporosis in Icelandic postmenopausal women." Thesis, Boston University, 2012. https://hdl.handle.net/2144/31565.
Повний текст джерелаPLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.
Background: In 2001 an assessment tool for predicting fracture risk in postmenopausal women was developed. An index based on a small number of risk factors that are easily assessed was developed called the Fracture Index. The value of this index ranges from 0-13 with higher number associated with higher five year probability of fracture. The magnitude of the morbidity and mortality associated with osteoporosis makes it valuable for health care professionals to know if a treatment to prevent fractures is cost effective or not. Objective: To investigate at what Fracture Index value it becomes cost effective to treat postmenopausal women with alendronate to prevent hip fractures. The focus is on Icelandic women. Design: A Markov model was developed to model the disease progression for women 65 years of age to 85 years of age which is the average life expectancy for women in Iceland. Cost effectiveness of alendronate vs. no treatment was assessed by transitioning women in the model every six months between different health states. In the base-case five year treatment with alendronate was assumed. Results: At Fracture Index 1-2 the incremental cost effectiveness ratio (ICER) was 27,467,073 ISK (238,844$) which is not considered to be cost effective. At Fracture Index 3-4 the ICER was 4,349,2511SK (37,820$) which has a 59% probability of being cost effective if the per capita GOP (4,800,000 ISK) for Iceland is used as a threshold for cost effectiveness. However cost effectiveness for Fracture Index 3-4 depends largely on the assumptions made in the model, some of which are uncertain such as drug cost, drug efficacy and appropriate discount rate. Treatment with Alendronate is cost effective for Fracture Index 5 and variation in the model's assumptions does not change that result. Conclusions: The results of this study indicate that treating osteoporotic women with alendronate to prevent hip fractures becomes cost effective at Fracture Index 5 with a 1.9% five year probability of hip fracture.
2031-01-01
Karlsson, Elin. "Investigation and treatment after an osteoporotic fracture: : A survey of the Fracture Liaison Service in Örebro County." Thesis, Örebro universitet, Institutionen för medicinska vetenskaper, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-72999.
Повний текст джерелаMartinek, Melissa Ann. "Knowledge, Causes, and Risk Factors Associated with Fractures in the Elderly Population at Hospital Zacamil in El Salvador." Diss., Virginia Tech, 2011. http://hdl.handle.net/10919/77205.
Повний текст джерелаPh. D.
Rice, Michael Blair. "Effects of type-I collagen fractional composition and pyridinium crosslink content on cortical bone strength in the human femur." Morgantown, W. Va. : [West Virginia University Libraries], 2001. http://etd.wvu.edu/templates/showETD.cfm?recnum=1840.
Повний текст джерелаTitle from document title page. Document formatted into pages; contains viii, 88 p. : ill. (some col.). Includes abstract. Includes bibliographical references (p. 81-88).
Brondani, Juliana Ebling. "CONSUMO ALIMENTAR DE CÁLCIO, FÓSFORO, MAGNÉSIO, PROTEÍNAS E ESTADO NUTRICIONAL EM MULHERES HOSPITALIZADAS POR FRATURAS OSTEOPORÓTICAS EM UM HOSPITAL UNIVERSITÁRIO." Universidade Federal de Santa Maria, 2015. http://repositorio.ufsm.br/handle/1/5849.
Повний текст джерелаIntrodução: Atualmente, o aumento da expectativa de vida das pessoas reflete a mudança no perfil epidemiológico brasileiro e, uma das maiores consequências enfrentadas devido a esse contexto é o aumento na prevalência de morbidades crônicas, dentre elas, a osteoporose. Essa patologia afeta especialmente as mulheres na pós-menopausa e suas principais consequências são as fraturas, responsáveis por uma elevada morbimortalidade e custos onerosos para o tratamento. No entanto, a nutrição representa um importante papel na formação e manutenção da massa óssea. Considerada como parte do tratamento não farmacológico, a alimentação variada, em qualidade e quantidade, muito provavelmente fornecerá os nutrientes necessários para manter, pelo menos em parte, uma saúde óssea regular durante o envelhecimento. Além disso, pode ser um possível fator de proteção para as principais consequências da osteoporose em idosos. Objetivo: Descrever o consumo alimentar de cálcio, fósforo, magnésio e proteínas em mulheres hospitalizadas por fraturas osteoporóticas em um serviço de Atenção Terciária de um município do interior do Rio Grande do Sul/RS. Metodologia: Estudo caso-controle, composto por 62 mulheres com 55 anos ou mais, sendo 42 no grupo com fraturas e, 20 sem fraturas. Aplicaram-se dois questionários, um contendo identificação, dados clínicos, história social e avaliação antropométrica e, outro para avaliar a ingestão de cálcio, fósforo, magnésio e proteínas, sendo o Questionário Quantitativo de Frequência de Alimentos (QQFA). Resultados: Ingestão de cálcio e magnésio foi significativamente baixa em mulheres com fraturas [446,9 mg/dia vs. 689,90 mg/dia e 135,49 mg/dia e 188,92 mg/dia, respectivamente]. Na análise de regressão logística para fraturas, aumento na ingestão de cálcio e magnésio foi associado com baixo risco para fraturas. Este resultado foi ajustado para idade e IMC. Não houve diferenças na ingestão de proteínas e fósforo entre os grupos. Na análise de regressão logística para fraturas, cálcio e magnésio foram considerados fatores de proteção, enquanto que a idade foi considerada fator de risco para fraturas. Conclusão: Ambos os grupos apresentaram ingestão de cálcio e magnésio bem abaixo das atuais recomendações para sexo e faixa etária. Em relação aos fatores associados às fraturas, ingestão dietética de cálcio e magnésio foi considerada como protetora contra fraturas ósseas.
Pilon, Danielle. "Oral anticoagulants and the risk of an osteoporotic fracture among the elderly." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=33823.
Повний текст джерелаMethods. We conducted a case-control study on subjects aged 70 years and older enrolled in the Quebec health insurance plan between 1992 and 1994. Incident cases of an osteoporotic fracture (index event) were identified by ICD-9 codes and surgical procedure codes. Exposure defined as one or more prescriptions of oral anticoagulants dispensed before the index event. Ten controls for each case, matched by age and date of index event, were selected.
Results. Among 1,523 cases, 48 (3.2%) were exposed to oral an anticoagulant; among 15,205 controls, 461 (3.0%) were exposed (adjusted odds ratio: 1.1, 95% CI: 0.8--1.4). These negative results persisted after stratifying the exposure into the cumulative dose and duration of treatment.
Conclusions. Oral anticoagulants are not significantly associated with an osteoporotic fracture in the elderly.
Beavan, S. R. "The biochemical and genetic basis of ethnic differences in osteoporotic fracture incidence." Thesis, University of Cambridge, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.596507.
Повний текст джерелаKATO, FUMIHIKO, NAOKI ISHIGURO, MASAAKI MACHINO, KEIGO ITO, YASUTSUGU YUKAWA, and HIROAKI NAKASHIMA. "COMBINED POSTERIOR-ANTERIOR SURGERY FOR OSTEOPOROTIC DELAYED VERTEBRAL FRACTURE WITH NEUROLOGIC DEFICIT." Nagoya University School of Medicine, 2014. http://hdl.handle.net/2237/20549.
Повний текст джерела