Готові списки джерел за темами / Osteoinductive capacity

Добірка наукової літератури з теми "Osteoinductive capacity"

Автор: Grafiati

Опубліковано: 10 грудня 2022

Оновлено: 28 січня 2023

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Статті в журналах з теми "Osteoinductive capacity"

Phillips, G. O., S. Al-Assaf, P. A. Williams, A. du Plessis, and C. J. Yim. "Radiation demineralised bone enhanced osteoinductive capacity after transplantation." Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms 265, no. 1 (December 2007): 390–93. http://dx.doi.org/10.1016/j.nimb.2007.09.011.

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Ding, Zhaozhao, Guozhong Lu, Weinan Cheng, Gang Xu, Baoqi Zuo, Qiang Lu, and David L. Kaplan. "Tough Anisotropic Silk Nanofiber Hydrogels with Osteoinductive Capacity." ACS Biomaterials Science & Engineering 6, no. 4 (March 18, 2020): 2357–67. http://dx.doi.org/10.1021/acsbiomaterials.0c00143.

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Delloye, Christian, Alain Hebrant, Everard Munting, Louis Piret, and Leopold Coutelier. "The osteoinductive capacity of differently HCI-decalcified bone alloimplants." Acta Orthopaedica Scandinavica 56, no. 4 (January 1985): 318–22. http://dx.doi.org/10.3109/17453678508993024.

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Kikionis, Stefanos, Efstathia Ioannou, Eleni Aggelidou, Leto-Aikaterini Tziveleka, Efterpi Demiri, Athina Bakopoulou, Spiros Zinelis, Aristeidis Kritis, and Vassilios Roussis. "The Marine Polysaccharide Ulvan Confers Potent Osteoinductive Capacity to PCL-Based Scaffolds for Bone Tissue Engineering Applications." International Journal of Molecular Sciences 22, no. 6 (March 17, 2021): 3086. http://dx.doi.org/10.3390/ijms22063086.

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Hybrid composites of synthetic and natural polymers represent materials of choice for bone tissue engineering. Ulvan, a biologically active marine sulfated polysaccharide, is attracting great interest in the development of novel biomedical scaffolds due to recent reports on its osteoinductive properties. Herein, a series of hybrid polycaprolactone scaffolds containing ulvan either alone or in blends with κ-carrageenan and chondroitin sulfate was prepared and characterized. The impact of the preparation methodology and the polysaccharide composition on their morphology, as well as on their mechanical, thermal, water uptake and porosity properties was determined, while their osteoinductive potential was investigated through the evaluation of cell adhesion, viability, and osteogenic differentiation of seeded human adipose-derived mesenchymal stem cells. The results verified the osteoinductive ability of ulvan, showing that its incorporation into the polycaprolactone matrix efficiently promoted cell attachment and viability, thus confirming its potential in the development of biomedical scaffolds for bone tissue regeneration applications.

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Chai, Yanjun, Dan Lin, Yifan Ma, Yuan Yuan, and Changsheng Liu. "RhBMP-2 loaded MBG/PEGylated poly(glycerol sebacate) composite scaffolds for rapid bone regeneration." Journal of Materials Chemistry B 5, no. 24 (2017): 4633–47. http://dx.doi.org/10.1039/c7tb00505a.

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Lindholm, T. Sam, and Tom C. Lindholm. "The Skull Defect Model in Measuring Osteoinductivity." Journal of Musculoskeletal Research 02, no. 02 (June 1998): 123–39. http://dx.doi.org/10.1142/s0218957798000147.

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Research on regeneration and experimental or clinical repair of cranial defects commenced already one hundred years ago. Principally spontaneous regeneration, intramembraneous bone healing, starts from the edges, proceeding to the center of the defect. A skull defect exceeding some critical limitations lacks the capacity for spontaneous healing. This kind of situation is named a "critical size" defect. The skull defect model is eminently suitable for testing osteoconduction and induction following local implantation of biomaterials and growth factors. There are numerous reports especially on osteoinductive proteins, native and recombinant bone morphogenetic proteins (BMPs), showing satisfactory complete healing of critical size skull defects in a relatively short period of time, while untreated defects have not had the capacity for complete regeneration. This article is a review of skull defect healing in different animal species showing optimized osteoinductive regenerative capacity especially with the use of BMPs. The results, indeed, also have clinical implications.

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Pekkarinen, Tarmo, T. Sam Lindholm, Aulis Marttinen, Oili Hietala, and Pekka Jalovaara. "INFLUENCE OF ETHYLENE OXIDE STERILIZATION ON NEW BONE FORMATION INDUCED BY BOVINE BONE MORPHOGENETIC PROTEIN." Journal of Musculoskeletal Research 04, no. 04 (December 2000): 287–95. http://dx.doi.org/10.1142/s021895770000032x.

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Bone morphogenetic proteins (BMPs) have the capacity to induce and accelerate bone regeneration. Before experimental and clinical settings, BMP must be sterilized. Ethylene oxide (EO) gas sterilizations at different temperatures are commonly used but the effects of that on the osteoinductive capacity of BMP have been the subject of controversy. Here, we investigated the effects of three different EO sterilization methods on the osteoinductivity of partially purified native bovine BMP (bBMP). Gelatin capsules containing 3 mg of bBMP were sterilized as follows: (i) manually inside a dessicator with 12% EO spray (20°C, exposure time 2 h); (ii) with an EO gas sterilizer (Steri-Vac 4XL, temperature 29°C, exposure time 4 h 10 min, ethylene oxide concentration 860 mg/l); (iii) with an EO gas sterilizer (Steri-Vac 5XL, temperature 42°C, exposure time 3 h, ethylene oxide concentration 700 mg/l). The sterilization processes were monitored with samples of Bacillus subtilis (3M, Attest 1264). Osteoinductivity of bBMP was verified by bioassay. After 21 days of implantation of bBMP into the muscle pouches of mice, the animals were killed and new bone formation was measured radiographically and histologically. The EO sterilization techniques used did not significantly decrease the osteoinductive activity of BMP. It is concluded that commercial EO gas equipment sterilization is effective for sterilized BMP and does not decrease the osteoinductive capacity of bovine BMP.

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Choi, Ji-Bong, Yu-Kyoung Kim, Seon-Mi Byeon, Jung-Eun Park, Tae-Sung Bae, Yong-Seok Jang, and Min-Ho Lee. "Characteristics of Biodegradable Gelatin Methacrylate Hydrogel Designed to Improve Osteoinduction and Effect of Additional Binding of Tannic Acid on Hydrogel." Polymers 13, no. 15 (July 31, 2021): 2535. http://dx.doi.org/10.3390/polym13152535.

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In this study, a hydrogel using single and double crosslinking was prepared using GelMA, a natural polymer, and the effect was evaluated when the double crosslinked hydrogel and tannic acid were treated. The resulting hydrogel was subjected to physicochemical property evaluation, biocompatibility evaluation, and animal testing. The free radicals generated through APS/TEMED have a scaffold form with a porous structure in the hydrogel, and have a more stable structure through photo crosslinking. The double crosslinked hydrogel had improved mechanical strength and better results in cell compatibility tests than the single crosslinked group. Moreover, in the hydrogel transplanted into the femur of a rat, the double crosslinked group showed an osteoinductive response due to the attachment of bone minerals after 4 and 8 weeks, but the single crosslinked group did not show an osteoinductive response due to rapid degradation. Treatment with a high concentration of tannic acid showed significantly improved mechanical strength through H-bonding. However, cell adhesion and proliferation were limited compared to the untreated group due to the limitation of water absorption capacity, and no osteoinduction reaction was observed. As a result, it was confirmed that the treatment of high-concentration tannic acid significantly improved mechanical strength, but it was not a suitable method for improving bone induction due to the limitation of water absorption.

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Xu, Ji, Yuan He, Yanan Sun, Xiuming Zhang, Yunfeng Yi, Wei Shi, and Dongtao Ge. "Micropatterned Polypyrrole/Hydroxyapatite Composite Coatings Promoting Osteoinductive Activity by Electrical Stimulation." Coatings 12, no. 6 (June 17, 2022): 849. http://dx.doi.org/10.3390/coatings12060849.

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Conductive polypyrrole (PPy) has excellent biocompatibility and structural stability. It is an ideal electroactive biomaterial that can apply exogenous electrical stimulation to promote osteoblast differentiation. However, PPy is a kind of bio-inert material, which does not have osteoinductive capacity. Therefore, we have introduced a kind of bioactive material, hydroxyapatite (HA), to construct PPy/HA composite to enhance bioactivity and osteoinduction. In addition, micron-topological morphology of scattered grid pattern has been designed and introduced to the PPy/HA coatings, which can further enhance the regulation ability of the coatings to the adhesion, proliferation and differentiation of MC3T3-E1 cells. In vitro simulated body fluids (SBFs) immersion test results have demonstrated that the fabricated micropatterned PPy/HA composite coatings perform bioactivity well and can promote the mineral deposition of HA on the surface. Moreover, it can also benefit the proliferation and osteognetic differentiation of MC3T3-E1 cells, when accompanied by external electrical stimulation (ES). In this study, we have successfully constructed electroactive and bioactive coatings, the method of which can potentially be applied to the surface functional modification of traditional bone repair metals.

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Forell, Elaine, Barbara Powers, J. Johnson, Mary Cooper, St J. Withrow, and R. C. Straw. "Evaluation of the Osteoinductive Capacity of Canine Demineralized Bone Matrix in Heterotopic Muscle Sites of Athymic Rats." Veterinary and Comparative Orthopaedics and Traumatology 06, no. 01 (1993): 21–28. http://dx.doi.org/10.1055/s-0038-1633051.

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SummaryThe osteoinductive capacity of canine demineralized bone matrix (DBM), implanted in epaxial muscle sites of athymic rats, was evaluated using calcium content and histomorphometry at two, four and six weeks after implantation. Results of this study confirm that DBM, derived from canine sources, does possess significant osteoinductive ability since histological examination revealed the presence of new cartilage, bone, or both, at 21/24 implantation sites. The osteogenesis induced by canine DBM continued as an active, cumulative process throughout the six week investigation period. The mean percentage of total induced osteogenic components including new, live cartilage, woven bone, lamellar bone and bone marrow cellular elements, was significantly greater after six weeks than after two weeks of implantation (p <0.01). Comparison of histomorphometric point counts at two, four and six weeks of implantation supported the conclusion that bone for mation as induced by canine DBM, proceeds primarily via an endochondral ossification pathway. Although the amount of calcium deposited in tissues harvested from DBM implanted sites tended to increase as implantation time lengthened, there was not a statistically significant correlation between calcium content and the level of osteogenic activity seen histologically (r = 0.32, p = 0.13).The osteoinductive capacity of canine demineralized bone matrix (DBM), implanted in ep-axial muscle sites of athymic rats, was evaluated using calcium content and histomorphometry at two, four and six weeks after implantation. Results of this investigation confirm that DBM, derived from canine sources, does possess significant osteo-inductive ability and that bone formation proceeds primarily via a pathway of endochondral ossification.

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Більше джерел

Дисертації з теми "Osteoinductive capacity"

van, Daalen Tessa Eline. "Effect of particle size on osteoinductive capacity of strontium substituted bioactive glasses (SrBG) in vitro." Thesis, Queensland University of Technology, 2021. https://eprints.qut.edu.au/225932/1/Tessa%20Eline_van%20Daalen_Thesis.pdf.

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Анотація:

Current clinical treatments for bone defects rely on donors or synthetic crafts, which are both associated with various complications such as limited availability, donor side morbidity and immune rejection. Thus, there is a strong need for “off the shelf” available bone implants with the ability to induce bone regeneration by host cells. Therefore, 3D printed composite bone crafts have been developed using a cost-effective bioresorbable polymer in combination with the ceramic "bioactive glass" to improve cell attachment. Here, Bioactive glass particles were reduced in size to increase surface area to hypothetically further stimulate bone tissue deposition by the host cells.

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