Добірка наукової літератури з теми "Osteocyte differentiation"
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Статті в журналах з теми "Osteocyte differentiation"
Kramer, Ina, Christine Halleux, Hansjoerg Keller, Marco Pegurri, Jonathan H. Gooi, Patricia Brander Weber, Jian Q. Feng, Lynda F. Bonewald та Michaela Kneissel. "Osteocyte Wnt/β-Catenin Signaling Is Required for Normal Bone Homeostasis". Molecular and Cellular Biology 30, № 12 (19 квітня 2010): 3071–85. http://dx.doi.org/10.1128/mcb.01428-09.
Повний текст джерелаZhang, Keqin, Cielo Barragan-Adjemian, Ling Ye, Shiva Kotha, Mark Dallas, Yongbo Lu, Shujie Zhao, et al. "E11/gp38 Selective Expression in Osteocytes: Regulation by Mechanical Strain and Role in Dendrite Elongation." Molecular and Cellular Biology 26, no. 12 (June 15, 2006): 4539–52. http://dx.doi.org/10.1128/mcb.02120-05.
Повний текст джерелаSkottke, Gelinsky, and Bernhardt. "In Vitro Co-culture Model of Primary Human Osteoblasts and Osteocytes in Collagen Gels." International Journal of Molecular Sciences 20, no. 8 (April 23, 2019): 1998. http://dx.doi.org/10.3390/ijms20081998.
Повний текст джерелаDu, J. H., S. X. Lin, X. L. Wu, S. M. Yang, L. Y. Cao, A. Zheng, J. N. Wu, and X. Q. Jiang. "The Function of Wnt Ligands on Osteocyte and Bone Remodeling." Journal of Dental Research 98, no. 8 (July 2019): 930–38. http://dx.doi.org/10.1177/0022034519854704.
Повний текст джерелаPesce Viglietti, Ayelén Ivana, Paula Constanza Arriola Benitez, María Virginia Gentilini, Lis Noelia Velásquez, Carlos Alberto Fossati, Guillermo Hernán Giambartolomei та María Victoria Delpino. "Brucella abortus Invasion of Osteocytes Modulates Connexin 43 and Integrin Expression and Induces Osteoclastogenesis via Receptor Activator of NF-κB Ligand and Tumor Necrosis Factor Alpha Secretion". Infection and Immunity 84, № 1 (12 жовтня 2015): 11–20. http://dx.doi.org/10.1128/iai.01049-15.
Повний текст джерелаWu, Qing, Xiaokang Zhou, Danqing Huang, Yingchen JI, and Feiwu Kang. "IL-6 Enhances Osteocyte-Mediated Osteoclastogenesis by Promoting JAK2 and RANKL Activity In Vitro." Cellular Physiology and Biochemistry 41, no. 4 (2017): 1360–69. http://dx.doi.org/10.1159/000465455.
Повний текст джерелаGao, Zheng-Rong, Qiong Liu, Jie Zhao, Ya-Qiong Zhao, Li Tan, Shao-Hui Zhang, Ying-Hui Zhou, Yun Chen, Yue Guo, and Yun-Zhi Feng. "A comprehensive analysis of the circRNA–miRNA–mRNA network in osteocyte-like cell associated with Mycobacterium leprae infection." PLOS Neglected Tropical Diseases 16, no. 5 (May 2, 2022): e0010379. http://dx.doi.org/10.1371/journal.pntd.0010379.
Повний текст джерелаIlas, Dragos C., Sarah M. Churchman, Thomas Baboolal, Peter V. Giannoudis, Joseph Aderinto, Dennis McGonagle, and Elena Jones. "The simultaneous analysis of mesenchymal stem cells and early osteocytes accumulation in osteoarthritic femoral head sclerotic bone." Rheumatology 58, no. 10 (April 16, 2019): 1777–83. http://dx.doi.org/10.1093/rheumatology/kez130.
Повний текст джерелаCherniack, E. Paul, Sahithi Chekuri, and Heather F. Lee. "Potential Non-neoplastic Applications for Polyphenols in Stem Cell Utilization." Current Drug Targets 20, no. 3 (January 25, 2019): 347–53. http://dx.doi.org/10.2174/1389450119666180731092453.
Повний текст джерелаZhang, Lanlan, and Chunyi Wen. "Osteocyte Dysfunction in Joint Homeostasis and Osteoarthritis." International Journal of Molecular Sciences 22, no. 12 (June 17, 2021): 6522. http://dx.doi.org/10.3390/ijms22126522.
Повний текст джерелаДисертації з теми "Osteocyte differentiation"
Scully, Nicole. "Differentiation of osteoblasts to osteocytes in 3D type I collagen gels : a novel tool to study osteocyte responses to mechanical loading." Thesis, Cardiff University, 2015. http://orca.cf.ac.uk/72592/.
Повний текст джерелаZambuzzi, Willian Fernando. "Mecanismos de transdução de sinal envolvidos com a diferenciação de osteoblastos e osteocitos." [s.n.], 2008. http://repositorio.unicamp.br/jspui/handle/REPOSIP/314046.
Повний текст джерелаTese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia
Made available in DSpace on 2018-08-10T21:31:55Z (GMT). No. of bitstreams: 1 Zambuzzi_WillianFernando_D.pdf: 4779822 bytes, checksum: 33696a8be638dbe16ec5d944f0e3b0d2 (MD5) Previous issue date: 2008
Resumo: Este trabalho teve como principal objetivo investigar os mecanismos de transdução de sinal disparados durante a diferenciação de células ósseas. Desta forma, vários aspectos moleculares desse processo foram analisados. A modulação da Src kinase pela proteína tirosina fosfatase de baixo peso molecular (LMWPTP) é essencial para a diferenciação dos pré-osteoblastos induzida pelo ácido ascórbico/glicerofosfato. Outro enfoque dado nesse trabalho foi a avaliação, sob o aspecto molecular e morfológico, da diferenciação de pré-osteoblastos em ¿osteocyte-like cells¿, processo esse induzido quando o Matrigel foi utilizado como substrato. De forma inédita demonstramos que nessa condição as células produziram a proteína sonic hedgehog (Shh), a qual também foi essencial para o processo de diferenciação. A análise do perfil quinômico dessas células apontou uma prevalência das quinases envolvidas com a comunicação celular. Este fato é coerente com a super-expressão de conexina 43 observada. Além disso, observamos que RECK e TIMP-1 modulam a atividade do rearranjo da matriz extracelular durante a diferenciação de osteoblastos, bem como o requerimento das proteínas PP2A e p38 MAPK durante a adesão de osteoblastos. Adicionalmente observamos uma modulação refinada das PTPs (LMWPTP, SHP2 e PTPa) bem como do status redox celular. Os resultados em conjunto demonstram que o estudo de transdução de sinal pode fornecer informações importantes para o entendimento do funcionamento celular bem como definir alvos moleculares que podem servir como ferramentas para diferentes aplicações
Abstract: The main goal of this work was to investigate the signal transduction pathways triggered during the bone cells differentiation. In this way, several molecular aspects of this process were analyzed. Src kinase modulation by the low molecular weight protein tyrosine phosphatase (LMWPTP) was essential for the occurrence of the differentiation induced by ascorbic acid and glycerophosphate. We also evaluated, under molecular and morphological patterns, the differentiation of pre-osteoblasts into osteocyte-like cells induced by 3D scaffold (matrigel as substrate). Interestingly, under this condition, the cells produced sonic hedgehog (Shh), which also was essential for stimulating the differentiation signaling pathway. Kinomic profiling of these cells revealed a prevalence of kinases involved in cellular communication, which is in agreement with the overexpression of connexin 43 observed. Besides we observed that RECK and TIMP-1 modulated the extracellular matrix rearrangement and that PP2A and p38 MAPK are required for osteoblasts adhesion. In addition, we observed that during pre-osteoblasts differentiation both PTPs and cellular redox are tightly regulated. Our findings demonstrated that the signal transduction evaluation can provide important information for understanding the cell biology as well as defining molecular targets that can be useful for different applications
Doutorado
Bioquimica
Doutor em Biologia Funcional e Molecular
Osta, Bilal. "Effects of Interleukine-17A (Il-17A) and tumor necrosis factor alpha (TNF-α) on osteoblastic differentiation". Thesis, Lyon 1, 2014. http://www.theses.fr/2014LYO10278/document.
Повний текст джерелаInterleukin-17A (IL-17A) and tumor necrosis factor alpha (TNF-α) are pro-inflammatory cytokines involved in the pathogenesis of several arthritic diseases. In rheumatoid arthritis (RA), joint damage is a result of an increase in bone destruction and a decrease in bone repair. In contrast, in ankylosing spondylitis (AS), a bone mass loss accompanied by a significant ectopic ossification is observed leading to the formation of syndesmophytes. Recent studies led to contradictory findings regarding the role of IL-17A and TNF-α in arthritic disease. Therefore, our objective was to study the effect of these two cytokines on the osteogenic differentiation of isolated human mesenchymal stem cells (hMSCs) and fibroblasts of the synovial membrane (FLS). In all the cell models used, we demonstrated that Il-17A and TNF α synergistically increase osteogenesis. This seems to approach the model of AS where ectopic bone formation is observed and in which IL-17A and TNF-α both are involved. These cytokines stimulate osteoclasts locally resulting in loss of bone mass observed in both RA and osteoporosis. Thus, targeting IL-17A and TNF-α could lead to a decrease in cell infiltration and joint destruction which is observed in RA and may reduce the effects of RA FLS on the activation of osteoclastogenesis
Azab, Ehab. "Osteocytes control myeloid cell proliferation and differentiation through GSα-dependent and -independent mechanisms". Thesis, 2018. https://hdl.handle.net/2144/30056.
Повний текст джерела2020-06-26T00:00:00Z
Skritakis, Pantos Angelo. "Characterization of the in vitro growth and differentiation capabilities of human adipose-derived mesenchymal progenitor cells." Thesis, 2019. https://hdl.handle.net/2144/36623.
Повний текст джерелаЧастини книг з теми "Osteocyte differentiation"
Pulica, Rachael, Karine Cohen Solal, and Ahmed Lasfar. "Role of RUNX2 in Melanoma: A New Player in Tumor Progression and Resistance to Therapy." In Melanoma. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.97105.
Повний текст джерелаSotoca, Ana M., Michael Weber, and Everardus J. J. van Zoelen. "Gene Expression Regulation underlying Osteo-, Adipo-, and Chondro-Genic Lineage Commitment of Human Mesenchymal Stem Cells." In Medical Advancements in Aging and Regenerative Technologies, 76–94. IGI Global, 2013. http://dx.doi.org/10.4018/978-1-4666-2506-8.ch004.
Повний текст джерелаLi, Chenghai. "Isolation and Expansion of Mesenchymal Stem/Stromal Cells, Functional Assays and Long-Term Culture Associated Alterations of Cellular Properties." In Cell Culture [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.100286.
Повний текст джерелаТези доповідей конференцій з теми "Osteocyte differentiation"
Cugno, Chiara, Ganesh Halade, and Md Mizanur Rahman. "Omega-3 fatty acid-rich fish oil supplementation prevents rosiglitazone-induced osteopenia in aging mice." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2021. http://dx.doi.org/10.29117/quarfe.2021.0099.
Повний текст джерела