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Tamimi, F., and X. Wu. "Osseointegration Pharmacology." JDR Clinical & Translational Research 2, no. 3 (March 24, 2017): 211–13. http://dx.doi.org/10.1177/2380084417701897.
Повний текст джерелаАнотація:
The process of osseointegration around dental implants is similar to the biological events occurring during bone repair and fracture healing. Therefore, bone metabolic activity plays a crucial role on the success of osseointegration, and dysregulation of bone metabolism can have a negative impact on bone healing and implant osseointegration. Accordingly, it could be hypothesized that drugs interfering with healing and bone metabolism could affect osseointegration and implant survival. Looking into the relationship between pharmacology, osseointegration, and dental implants, drugs can open the door for new pharmacological innovations to improve implant success and avoid unnecessary complications, and it is also of special interest because most implant patients are elder adults who are often polymedicated. In this commentary, we discuss the discoveries made by us as well as by other researchers regarding the effect of several drugs on bone, osseointegration, and implant survival. Of particular interest is the growing evidence showing that commonly used drugs such as nonsteroidal anti-inflammatories, serotonin reuptake inhibitors, and proton pump inhibitors could lead to implant failure.
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Yi, Young-Ah, Young-Bum Park, Hyunmin Choi, Keun-Woo Lee, Sun-Jai Kim, Kwang-Mahn Kim, Seunghan Oh, and June-Sung Shim. "The Evaluation of Osseointegration of Dental Implant Surface with Different Size of TiO2Nanotube in Rats." Journal of Nanomaterials 2015 (2015): 1–11. http://dx.doi.org/10.1155/2015/581713.
Повний текст джерелаАнотація:
With the development of nanotechnology, many researches have shown that nanometer-scaled materials especially TiO2nanotube have a positive effect on cellular behavior and surface characteristics of implant, which are considered to be crucial factors in osseointegration. However, it has not yet been verified which nanotube size is effective in osseointegrationin vivo. The aim of this study was to evaluate the effect of implant surface-treated with different size of TiO2nanotubes on osseointegration in rat femur. The customized implants (threaded and nonthreaded type), surface-treated with different diameter of TiO2nanotubes (30 nm, 50 nm, 70 nm, and 100 nm nanotube), were placed on both sides of the femur of 50 male Sprague-Dawley rats (6 weeks old). Rats were sacrificed at 2 and 6 weeks following surgery; then the specimens were collected by perfusion fixation and the osseointegration of implants was evaluated by radiographic and histologic analyses and removal torque value test. The mean of bone area (%) and the mean of removal torque were different in each group, indicating that the difference in TiO2nanotube size may influence new bone formation and osseointegration in rats.
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Papež, Jakub, Taťjana Dostálová, Karel Chleborád, Pavel Kříž, and Jakub Strnad. "Chronological Age as Factor Influencing the Dental Implant Osseointegration in the Jaw Bone." Prague Medical Report 119, no. 1 (2018): 43–51. http://dx.doi.org/10.14712/23362936.2018.4.
Повний текст джерелаАнотація:
The objectives of this study were to evaluate osseointegration of dental implant in the jaw bone in the young and elderly population and comparing the results to assess indicators and risk factors as age for the success or failure of dental implants. A retrospective study of 107 implants (Impladent, LASAK, Czech Republic) was prepared. The patients at implants surgery were divided in three groups. The patients were followed-up for a 7-year period. We evaluated osseointegration from long term point of view as a change of marginal bone levels close to dental implant. Marginal bone levels were recorded and analysed with regard to different patient- and implant-related factors. An influence of chronological age on change of marginal bone levels during 6-year retrospective study vas evaluated. The study examined 47 patient charts and 107 implants from the Second Faculty of Medicine, Charles University and University Hospital Motol. We proved that young healthy patients with long bridges or Branemarks have the same progression of marginal bone levels changes. The chronological age hasn’t therefore direct influence on the osseointegration from long term point of view. But we found that the length of dental suprastrucure-prosthetic construction negatively influences marginal bone changes, though these results weren’t statistically significant. More extensive dental implant suprastrucure undergoes smaller osseointegration. On the other hand the length of dental suprastrucure (prosthetic construction) negatively influences dental osseointegration in both groups of patient.
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Ciortea, Claudiu, Mariana Cărămidă, and Ioan Sîrbu. "Methods used to assess the osseointegration of dental implants." Romanian Journal of Stomatology 61, no. 3 (September 30, 2015): 243–49. http://dx.doi.org/10.37897/rjs.2015.3.6.
Повний текст джерелаАнотація:
The stability of dental implants is a prerequisite for osseointegration. Osseointegration is the process that involves the formation of bone around the dental implant, resulting in increased stability and its integration in the organism. Therefore, successful osseointegration contributes to a functionally optimal treatment. There is a need for a clinical method capable of measurement of bone quality at the time and following implant placement, to measure the degree of osseointegration and the ability of the implants to distribute loads to the surrounding bone. Research to date focuses on finding an ideal method to assess the osseointegration of dental implants in order to improve and broaden the clinical indications of dental implant systems. This paper aims to supply information about current methods used to assess the osseointegration of dental implants. In this regard, a literature review was conducted. Full-text scientific articles relevant to the chosen topic, written in English or whose text could be accessed in English were included.
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Thopte, Shameeka, Aastha Chopra, Amit A. Mhapuskar, Swati Marathe, Shams U. Nisa, and Rashmi Saddiwal. "Evaluation of Osseointegration in Implants using Digital Orthopantomogram and Cone Beam Computed Tomography." Journal of Contemporary Dental Practice 17, no. 11 (2016): 953–57. http://dx.doi.org/10.5005/jp-journals-10024-1961.
Повний текст джерелаАнотація:
ABSTRACT Introduction Accurate assessment of osseointegration in dental implants requires precise radiographic visualization of pathologic conditions as well as anatomical structures. The present study aimed to evaluate the formation of bony tissue (osseointegration) using digital orthopantomogram (OPG) and cone beam computed tomography (CBCT) immediately after implant insertion (within 7 days) and 3 months postinsertion. Materials and methods Twenty single-implant sites on mandibular posterior regions were selected on patients irrespective of their gender. Both digital OPG and CBCT were done within a week and again after 3 months of implant insertion surgery, using the same exposure parameters. Results Three of the 20 implants were submerged and were excluded as the crestal bone height could not be measured. The participants were recalled for radiographic measurements after 3 months of implant placement. On an average, there was 0.03 mm of osseointegration at the apical portion after 3 months of implant insertion on digital OPG; 0.04 mm of osseointegration at the crestal bone height after 3 months on digital OPG; and 0.01 mm of osseointegration at the apical portion after 3 months on CBCT. No change or ≤0.02 mm of osseointegration at crestal bone height after 3 months on CBCT. Conclusion Both digital OPG and CBCT are significant for the assessment of osseointegration in implants, and hence, endow definite benefit for accurate assessment in terms of the success of the implant placement. Clinical significance However, CBCT is a better mode of evaluating dental implants but one should keep in mind that radiographic examination must be conducted to the benefit of the patient by application of the lowest achievable dose. How to cite this article Chopra A, Mhapuskar AA, Marathe S, Nisa SU, Thopte S, Saddiwal R. Evaluation of Osseointegration in Implants using Digital Orthopantomogram and Cone Beam Computed Tomography. J Contemp Dent Pract 2016;17(11):953-957.
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Dong, Heng, Hui Liu, Na Zhou, Qiang Li, Guangwen Yang, Li Chen, and Yongbin Mou. "Surface Modified Techniques and Emerging Functional Coating of Dental Implants." Coatings 10, no. 11 (October 22, 2020): 1012. http://dx.doi.org/10.3390/coatings10111012.
Повний текст джерелаАнотація:
Dental implants are widely used in the field of oral restoration, but there are still problems leading to implant failures in clinical application, such as failed osseointegration, marginal bone resorption, and peri-implantitis, which restrict the success rate of dental implants and patient satisfaction. Poor osseointegration and bacterial infection are the most essential reasons resulting in implant failure. To improve the clinical outcomes of implants, many scholars devoted to modifying the surface of implants, especially to preparing different physical and chemical modifications to improve the osseointegration between alveolar bone and implant surface. Besides, the bioactive-coatings to promote the adhesion and colonization of ossteointegration-related proteins and cells also aim to improve the osseointegration. Meanwhile, improving the anti-bacterial performance of the implant surface can obstruct the adhesion and activity of bacteria, avoiding the occurrence of inflammation related to implants. Therefore, this review comprehensively investigates and summarizes the modifying or coating methods of implant surfaces, and analyzes the ossteointegration ability and anti-bacterial characteristics of emerging functional coatings in published references.
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Sayed, Mohammed E., Maryam H. Mugri, Mazen A. Almasri, Manea Musa Al-Ahmari, Shilpa Bhandi, Thodur Balaji Madapusi, Saranya Varadarajan, et al. "Role of Stem Cells in Augmenting Dental Implant Osseointegration: A Systematic Review." Coatings 11, no. 9 (August 27, 2021): 1035. http://dx.doi.org/10.3390/coatings11091035.
Повний текст джерелаАнотація:
Dental implants are a widely used treatment modality for oral rehabilitation. Implant failures can be a result of many factors, with poor osseointegration being the main culprit. The present systematic review aimed to assess the effect of stem cells on the osseointegration of dental implants. An electronic search of the MEDLINE, LILACS, and EMBASE databases was conducted. We examined quantitative preclinical studies that reported on the effect of mesenchymal stem cells on bone healing after implant insertion. Eighteen studies that fulfilled the inclusion criteria were included. Various surface modification strategies, sites of placement, and cell origins were analyzed. The majority of the selected studies showed a high risk of bias, indicating that caution must be exercised in their interpretation. All the included studies reported that the stem cells used with graft material and scaffolds promoted osseointegration with higher levels of new bone formation. The mesenchymal cells attached to the implant surface facilitated the expression of bio-functionalized biomaterial surfaces, to boost bone formation and osseointegration at the bone–implant interfaces. There was a promotion of osteogenic differentiation of human mesenchymal cells and osseointegration of biomaterial implants, both in vitro and in vivo. These results highlight the significance of biomodified implant surfaces that can enhance osseointegration. These innovations can improve the stability and success rate of the implants used for oral rehabilitation.
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Chaudhary, Shweta, and Siddhant Sachdeva. "CORRELATION OF DENTAL IMPLANTS SURFACE TEXTURE AND OSSEOINTEGRATION €“ A REVIEW ARTICLE." International Journal of Advanced Research 10, no. 06 (June 30, 2022): 295–99. http://dx.doi.org/10.21474/ijar01/14887.
Повний текст джерелаАнотація:
The key factor in success of dental implants is its ability to integrate with the surrounding bone, or in short, osseointegration. The events leading tosuccess or failure of osseointegration of a dental implant takes place mostly at the tissue- implant surface. It would be no doubt to say, that the implant surface offers the greatest potential to alter the process of osseointegration.Although the main purpose of surface modification of implants is to achieve better osseointegration, a shortened period of healing is desirable for both the clinician and the patient.
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Fang, Wen, Shifang Zhao, Fuming He, Li Liu, and Guoli Yang. "Influence of Simvastatin-Loaded Implants on Osseointegration in an Ovariectomized Animal Model." BioMed Research International 2015 (2015): 1–7. http://dx.doi.org/10.1155/2015/831504.
Повний текст джерелаАнотація:
The success of bone implants in the presence of osteoporosis is limited by lack of osseointegration between the implant and the natural bone. This study applied an electrochemical process to deposit simvastatin-nanohydroxyapatite (HA) coatings on porous implant surfaces and investigated the effects of these simvastatin-HA coatings on implant surfaces in an animal model of osteoporosis. In this study, simvastatin-HA coated implants were inserted into the tibia of osteoporotic rats. After 2, 4, and 12 weeks, tissue was retrieved for histomorphometric evaluation. The results indicated that the simvastatin-HA coatings increased bone-implant contact and new bone formation around implant surfaces. In conclusion, implants loaded with simvastatin by an electrochemical process improved implant osseointegration in osteoporotic rats. Furthermore, the increased concentration of simvastatin could affect the osseointegration, but the dose-effects also need further investigation.
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Lupi, Saturnino Marco, Mirko Torchia, and Silvana Rizzo. "Biochemical Modification of Titanium Oral Implants: Evidence from In Vivo Studies." Materials 14, no. 11 (May 24, 2021): 2798. http://dx.doi.org/10.3390/ma14112798.
Повний текст джерелаАнотація:
The discovery of osseointegration of titanium implants revolutionized the dental prosthesis field. Traditionally, implants have a surface that is processed by additive or subtractive techniques, which have positive effects on the osseointegration process by altering the topography. In the last decade, innovative implant surfaces have been developed, on which biologically active molecules have been immobilized with the aim of increasing stimulation at the implant–biological tissue interface, thus favoring the quality of osseointegration. Among these molecules, some are normally present in the human body, and the techniques for the immobilization of these molecules on the implant surface have been called Biochemical Modification of Titanium Surfaces (BMTiS). Different techniques have been described in order to immobilize those biomolecules on titanium implant surfaces. The aim of the present paper is to present evidence, available from in vivo studies, about the effects of biochemical modification of titanium oral implants on osseointegration.
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Pătrașcu, Ion, and Bogdan Mihai Gălbinașu. "Considerations regarding the osseointegration of endosseous dental implants." Romanian Journal of Stomatology 67, no. 1 (March 31, 2021): 48–52. http://dx.doi.org/10.37897/rjs.2021.1.8.
Повний текст джерелаАнотація:
Implant osseointegration has not been accepted over time, considering that in fact the implant integration is performed only in the soft tissue of the host. For this reason, the implant has never been sufficiently integrated into the host tissue immediately after insertion. Experiments performed in Branemark laboratories in the early 1960s, with a new type of implant, which required a direct anchorage to bone tissue for clinical function, this anchorage was called osseointegration. It has been shown that it is possible to achieve direct osseointegration if the Branemark method is considered, which was published a few years later in the first clinical report. The authors of this article come up with new contributions that validate the implant osseointegration process. Inside this article we present our methodology for evaluating the osseointegration of endosseous implants: ESEM (environmental scanning electron microscope) studies of the implant-bone tissue interface.
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Pandey, Chandrashekhar, Dinesh Rokaya, and Bishwa Prakash Bhattarai. "Contemporary Concepts in Osseointegration of Dental Implants: A Review." BioMed Research International 2022 (June 14, 2022): 1–11. http://dx.doi.org/10.1155/2022/6170452.
Повний текст джерелаАнотація:
In a society highly conscious of esthetics, prosthetic rehabilitation of lost teeth with tissue-integrated implants has gained wide acceptance and demand by patients and clinicians. The backbone of these tissue-integrated implants is the biotechnical process of osseointegration. Although the concept has been introduced and discussed for ages, the deepening knowledge about its cellular and molecular mechanisms has led the researchers to borrow further into the factors influencing the process of osseointegration. This has aided in the hastening and improving the process of osseointegration by exploiting several, even the minutest, details and events taking place in this natural process. Recently, due to the high esthetic expectations of the patients, the implants are being loaded immediately, which demands a high degree of implant stability. Implant stability, especially secondary stability, largely depends on bone formation and integration of implants to the osseous tissues. Various factors that influence the rate and success of osseointegration can either be categorized as those related to implant characteristics like the physical and chemical macro- and microdesign of implants or the bone characteristics like the amount and quality of bone and the local and systemic host conditions, or the time or protocol followed for the functional loading of the dental implant. To address the shortcomings in osseointegration due to any of the factors, it is mandatory that continuous and reliable monitoring of the status of osseointegration is done. This review attempts to encompass the mechanisms, factors affecting, and methods to assess osseointegration, followed by a discussion on the recent advances and future perspectives in dental implantology to enhance the process of osseointegration. The review was aimed at igniting the inquisitive minds to usher further the development of technology that enhances osseointegration.
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Anjum, Shamaa, and Arvina Rajasekar. "Surface Modification of Dental Implants - A Review." Journal of Evolution of Medical and Dental Sciences 10, no. 17 (April 26, 2021): 1246–50. http://dx.doi.org/10.14260/jemds/2021/265.
Повний текст джерелаАнотація:
The use of dental implants for the replacement of missing teeth has increased in the last 30 years. The success rates for implant placement depend on a series of both biological and clinical steps which starts with primary stability that is being provided by the amount, quality and the distribution of bone within the proposed implant site. The most important factor in implant osseointegration is surface roughness, which shows increased osteoblast activity at 1 to 100 μm of the surface roughness when compared to a smooth surface. Rough surfaces have excellent osseointegration than smooth surfaces, but the results of research have been diverse, and it is evident that multiple treatments provide good results. The surfaces of a dental implant have been modified in several ways to improve its biocompatibility and speed up osseointegration. Literature says that any surface modification provides a good surface for osseointegration of the implant when the surface roughness is about 0.44 ~ 8.68 μm. It is also said that acid etching and coating are the most preferred methods for creating good roughness of the implant surface. From animal studies, it is known that implant surface modifications provided by biomolecular coating seemed to enhance the osseointegration by promoting peri-implant bone formation in the early stages of healing. It also seemed to improve histomorphometric analysis and biomechanical testing results. This article reviews the surface modifications of dental implants for the achievement of better success rates. Various methods are used to modify the topography or the chemistry of the implant surfaces which includes acid etching, anodic oxidation, blasting, treatment with fluoride, and calcium phosphate coating. These modifications provide a faster and a stronger osseointegration.1 Recently, hydrophilic properties added to the roughened surfaces or some osteogenic peptides coated on the surfaces shows higher biocompatibility and have induced faster osseointegration compared to the existing modified surfaces. With development in surface engineering techniques, new information on the properties, behaviour, and the reaction of various materials could be discovered which in turn allows the discovery of new materials, modification techniques and design of bio implants for the future. KEY WORDS Dental Implants, Surface Modifications, Biocompatibility, Surface Topography
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Silva, Rayane C. S., Almerinda Agrelli, Audrey N. Andrade, Carina L. Mendes-Marques, Isabel R. S. Arruda, Luzia R. L. Santos, Niedja F. Vasconcelos, and Giovanna Machado. "Titanium Dental Implants: An Overview of Applied Nanobiotechnology to Improve Biocompatibility and Prevent Infections." Materials 15, no. 9 (April 27, 2022): 3150. http://dx.doi.org/10.3390/ma15093150.
Повний текст джерелаАнотація:
This review addresses the different aspects of the use of titanium and its alloys in the production of dental implants, the most common causes of implant failures and the development of improved surfaces capable of stimulating osseointegration and guaranteeing the long-term success of dental implants. Titanium is the main material for the development of dental implants; despite this, different surface modifications are studied aiming to improve the osseointegration process. Nanoscale modifications and the bioactivation of surfaces with biological molecules can promote faster healing when compared to smooth surfaces. Recent studies have also pointed out that gradual changes in the implant, based on the microenvironment of insertion, are factors that may improve the integration of the implant with soft and bone tissues, preventing infections and osseointegration failures. In this context, the understanding that nanobiotechnological surface modifications in titanium dental implants improve the osseointegration process arouses interest in the development of new strategies, which is a highly relevant factor in the production of improved dental materials.
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Altay, Mehmet Ali, Alper Sindel, Öznur Özalp, Nelli Yildirimyan, Dinçer Kader, Uğur Bilge, and Dale A. Baur. "Does the Intake of Selective Serotonin Reuptake Inhibitors Negatively Affect Dental Implant Osseointegration? A Retrospective Study." Journal of Oral Implantology 44, no. 4 (August 1, 2018): 260–65. http://dx.doi.org/10.1563/aaid-joi-d-17-00240.
Повний текст джерелаАнотація:
The success of osseointegration is influenced by several factors that affect bone metabolism and by certain systemic medications. Selective serotonin reuptake inhibitors (SSRIs) have been previously suggested to be among these medications. This study aims to investigate the association between systemic intake of SSRIs and failure of osseointegration in patients rehabilitated with dental implants. A retrospective cohort study was conducted, including a total of 2055 osseointegrated dental implants in 631 patients (109 implants in 36 SSRI \users and 1946 in 595 nonusers). Predictor and outcome variables were SSRI intake and osseointegration failure, respectively. The data were analyzed with Mann–Whitney test or Fisher exact test accordingly. Both patient-level and implant-level models were implemented to evaluate the effect of SSRI exposure on the success of osseointegration of dental implants. Median duration of follow-up was 21.5 months (range = 4–56 months) for SSRI users and 23 months (range –60 months) for nonusers (P = .158). Two of 36 SSRI users had 1 failed implant each; thus, the failure rate was 5.6%. Eleven nonusers also had 1 failed implant each; thus, the failure rate was 1.85%. The difference between the 2 groups failed to reach statistical significance at patient and implant levels (P = .166, P = .149, respectively). The odds of implant failure were 3.123 times greater for SSRI users compared with nonusers. Patients using SSRIs were found to be 3.005 times more likely to experience early implant failure than nonusers. The results of this study suggest that SSRIs may lead to increase in the rate of osseointegration failure, although not reaching statistical significance.
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Sachin, Palekar Gouri, Ashita S. Uppoor, and Sangeeta U. Nayak. "Nano-scale surface modification of dental implants – An emerging boon for osseointegration and biofilm control." Acta Marisiensis - Seria Medica 68, no. 4 (December 1, 2022): 154–58. http://dx.doi.org/10.2478/amma-2022-0029.
Повний текст джерелаАнотація:
Abstract Implant therapy is a commonly based method of replacing missing teeth. A range of physical, chemical, and biological modifications have been applied to the surface of titanium implants to improve their biological performance and osseointegration outcomes. Implant surface characteristics play an important function in several peri-implant cellular and molecular mechanisms. Clinicians are commonly placing dental implants with various surface roughness and modifications including plasma-sprayed, acid-etched, blasted, oxidized, hydroxyapatite-coated, or combinations of these procedures. Surface modifications are to facilitate early osseointegration and to ensure a long-term bone-to-implant contact without substantial marginal bone loss can be accomplished. It is apparent that different modifications have a range of beneficial effects, it is essential to consider at what time point and in what conditions these effects occur. This article reviews existing surface modification technologies of mainstream dental implants and the correlation between implant surface coatings and their performance of osseointegration or anti-bacterial ability it needs to be evaluated.
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Grishin, Petr, and Elena Kalinnikova. "CLINICAL STUDIES OF THE STABILITY AND PROCESS OF OSTEOINTEGRATION OF DENTAL IMPLANTS DURING IMMEDIATE AND DELAYED IMPLANTATION." Actual problems in dentistry 16, no. 4 (February 9, 2021): 97–103. http://dx.doi.org/10.18481/2077-7566-20-16-4-97-103.
Повний текст джерелаАнотація:
Subject. Analysis of the literature confirms that there is a definite relationship between surface microstructure, implant geometry, thread design and primary stability, and osseointegration processes. To date, a sufficient number of works on direct and delayed implantation have accumulated. However, there is not enough convincing clinical data on the quantitative assessment of primary stability at different periods of the osseointegration process. Despite the existence of experimental and clinical observations, it seems impossible to make a definite judgment about the mechanism of such a relationship. This chapter presents clinical studies of the stability and osseointegration of dental implants when performing, according to the indications, in 414 patients of direct and delayed implantation using implant systems with different surface microstructures.
Goal. Conduct clinical studies of quantitative indicators of stability and osseointegration of implants with different microstructure of the surface during direct and delayed implantation.
Methodology. For the clinical study of primary stability and the process of osseointegration during direct and delayed implantation with immediate functional loading, implant systems with different surface microstructures were used: Alfa Bio, Mis, Astra-Tech, Dentium, Ostem, Antogher, and also Humana Dental with an innovative surface. Osseointegrated implants have been used to achieve a predictable treatment outcome in clinical cases with partial or complete adentia, as well as in the presence of single, included defects.
Results. There were no significant differences in stability indicators at the time of implant placement in the alveolar bone, depending on the type of implant and the method of implantation.
Conclusions. In the process of integration of the implant into the bone tissue at a later date, the indicators of stability and osseointegration improve. The relationship between the appearance of the implant surface, primary stability and the time of its adaptation was revealed.
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Bosshardt, Dieter D., Urs R. Brodbeck, Florian Rathe, Thomas Stumpf, Jean-Claude Imber, Paul Weigl, and Markus Schlee. "Evidence of re-osseointegration after electrolytic cleaning and regenerative therapy of peri-implantitis in humans: a case report with four implants." Clinical Oral Investigations 26, no. 4 (March 4, 2022): 3735–46. http://dx.doi.org/10.1007/s00784-021-04345-1.
Повний текст джерелаАнотація:
Abstract Objective To evaluate re-osseointegration after electrolytic cleaning and regenerative therapy of dental implants with peri-implantitis in humans. Material and methods Four dental implants that developed peri-implantitis underwent electrolytic cleaning followed by regenerative therapy with guided bone regeneration. All four implants developed recurrent peri-implantitis and were therefore explanted 6 to 13 months later. Radiographic bone level, probing depth, and bleeding on probing were determined at the time of surgery, 6 months later, and before implant retrieval. The peri-implant tissues were histologically and histomorphometrically analyzed. Results All four implants demonstrated radiographic and histological bone gain, reduced probing depth, and bleeding on probing. Radiographic bone gain was 5.8 mm mesially and 4.8 mm distally for implant #1, 3.3 mm and 2.3 mm for implant #2, 3.1 mm and 0.5 mm for implant #3, and 3.5 mm and 2.8 mm for implant #4. The histometric mean and maximum vertical bone gain for implant #1 to #4 was 1.65 mm and 2.54 mm, 3.04 mm and 3.47 mm, 0.43 mm and 1.27 mm, and 4.16 mm and 5.22 mm, respectively. The percentage of re-osseointegration for implant #1 to #4 was 21.0%, 36.9%, 5.7%, and 39.0%, respectively. In one implant, the newly formed bone was deposited directly onto calculus on the implant surface. Conclusions We found that (1) re-osseointegration is possible on a formerly contaminated implant surface and (2) the electrolytic cleaning process seems to be effective enough at sites with calculus residues. Clinical relevance Since re-osseointegration can be achieved by electrolytic cleaning, this decontamination technique may be considered as a future treatment concept.
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Kämmerer, Till, Tony Lesmeister, Victor Palarie, Eik Schiegnitz, Andrea Schröter, Bilal Al-Nawas, and Peer W. Kämmerer. "Calcium Phosphate-Coated Titanium Implants in the Mandible: Limitations of the in vivo Minipig Model." European Surgical Research 61, no. 6 (2020): 177–87. http://dx.doi.org/10.1159/000513846.
Повний текст джерелаАнотація:
<b><i>Introduction:</i></b> We aimed to compare implant osseointegration with calcium phosphate (CaP) surfaces and rough subtractive-treated sandblasted/acid etched surfaces (SA) in an in vivo minipig mandible model. <b><i>Materials and Methods:</i></b> A total of 36 cylindrical press-fit implants with two different surfaces (CaP, <i>n</i> = 18; SA, <i>n</i> = 18) were inserted bilaterally into the mandible of 9 adult female minipigs. After 2, 4, and 8 weeks, we analyzed the cortical bone-to-implant contact (cBIC; %) and area coverage of bone-to-implant contact within representative bone chambers (aBIC; %). <b><i>Results:</i></b> After 2 weeks, CaP implants showed no significant increase in cBIC and aBIC compared to SA (cBIC: mean 38 ± 5 vs. 16 ± 11%; aBIC: mean 21 ± 1 vs. 6 ± 9%). Two CaP implants failed to achieve osseointegration. After 4 weeks, no statistical difference between CaP and SA was seen for cBIC (mean 54 ± 15 vs. 43 ± 16%) and aBIC (mean 43 ± 28 vs. 32 ± 6). However, we excluded two implants in each group due to failure of osseointegration. After 8 weeks, we observed no significant intergroup differences (cBIC: 18 ± 9 vs. 18 ± 20%; aBIC: 13 ± 8 vs. 16 ± 9%). Again, three CaP implants and two SA implants had to be excluded due to failure of osseointegration. <b><i>Conclusion:</i></b> Due to multiple implant losses, we cannot recommend the oral mandibular minipig in vivo model for future endosseous implant research. Considering the higher rate of osseointegration failure, CaP coatings may provide an alternative to common subtractive implant surface modifications in the early phase post-insertion.
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Huang, Bo, Jun Ye, Xiaohua Zeng, and Ping Gong. "Effects of capsaicin-induced sensory denervation on early implant osseointegration in adult rats." Royal Society Open Science 6, no. 1 (January 2019): 181082. http://dx.doi.org/10.1098/rsos.181082.
Повний текст джерелаАнотація:
The presence of nerve endings around implants is well-known, but the interaction between the peripheral nervous system and the osseointegration of implants has not been thoroughly elucidated to date. The purpose of this study was to test the effects of selective sensory denervation on early implant osseointegration. Forty male Sprague-Dawley rats were divided randomly into two groups, group A and group B, and they were treated with capsaicin and normal saline, respectively. One week later, titanium implants were placed in the bilateral femurs of the rats. Three and six weeks after implantation, histological examination, microcomputed tomography and biomechanical testing were performed to observe the effect of sensory denervation on implant osseointegration. At three weeks and six weeks, bone area, trabecular bone volume/total bone volume and bone density were significantly lower in group A than in group B. Similarly, the bone–implant contact rate, trabecular number and trabecular thickness were clearly lower in group A than in group B at three weeks. However, the trabecular separation spacing in group A was greater than that in group B at both time points. Biomechanical testing revealed that the implant-bone binding ability of group A was significantly lower than that in group B. The research demonstrated that sensory innervation played an important role in the formation of osseointegration. Selective-sensory denervation could reduce osseointegration and lower the binding force of the bone and the implant.
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Arakeeb, Mohamed Ali Ali, Ahmed Abbas Zaky, Tarek Abdel-Hamid Harhash, Walid S. Salem, and Mohamed El-Mofty. "Effect of Combined Application of Growth Factors and Diode Laser Bio-Stimulation on the Osseo Integration of Dental Implants." Open Access Macedonian Journal of Medical Sciences 7, no. 15 (August 12, 2019): 2520–27. http://dx.doi.org/10.3889/oamjms.2019.672.
Повний текст джерелаАнотація:
BACKGROUND: The success of implants is associated first with their osseointegration, and later on with their survival rate. In recent years, many efforts have been exerted to develop implant design, geometry, materials and techniques to enhance the osseointegration process and also to increase the success rate of implant procedures. New techniques, like leukocyte and platelet-rich fibrin (L-PRF) and low-level laser treatment (LLLT), have been developed to enhance the osseointegration around dental implants.
AIM: This study aims at accelerating bone osseointegration process around dental implant using new techniques to increase the success rate, to allow immediate or early loading of a dental implant, and to make a comparison between the various new techniques in dental implant procedures to figure out which technique will achieve the best results.
METHODS: The study was conducted on a random sample of 40 male patients. Dental implants were placed in the posterior areas of the lower jaw. Patients were divided randomly into 4 groups; control group, LLLT group, L-PRF group and L-PRF plus LLLT group. They were assessed using cone-beam computed tomography (CBCT).
RESULTS: The results showed significant differences between all groups over different measured times. All the groups showed improvement in comparison with Normal group, where L-PRF group showed the best result followed by (L-PRF+LLLT) group, while the LLLT group showed the least improvement in comparison with bothL-PRF group and (L-PRF+LLLT) group.
CONCLUSION: The study demonstrates that L-PRF gives a better performance in the osseointegration around dental implants than LLLT.
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Lang, N. P. "Oral Implants: The Paradigm Shift in Restorative Dentistry." Journal of Dental Research 98, no. 12 (October 21, 2019): 1287–93. http://dx.doi.org/10.1177/0022034519853574.
Повний текст джерелаАнотація:
The discovery of the phenomenon “osseointegration,” or functional ankylosis, has led to the development of oral implants with high clinical performance. Consequently, the placement of titanium implants has changed the paradigms of restorative dentistry. Implants are used to prevent placing reconstructions anchored on natural teeth when these are vital and intact. Furthermore, implants are suitable to improve subjective chewing function and to replace missing and strategically important abutments. The osseointegration process is characterized by a predictable sequence of healing events that encompass the formation of woven bone, parallel fibers, and lamellar bone and result in fully functional bone that will remodel throughout life. While the osseointegration facilitates the use of implants as prosthetic abutments, it has to be kept in mind that the peri-implant soft tissue may be subject to biological complications. This, in turn, may result in an infectious process that will jeopardize the osseointegration. Consequently, the monitoring of the peri-implant tissues is an important aspect, and early intervention in situations with peri-implant mucositis is mandatory for the prevention of peri-implantitis. Hence, it is evident that oral implants need lifelong maintenance care if their longevity is to be assured.
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Novaes Jr, Arthur Belém, Sérgio Luis Scombatti de Souza, Raquel Rezende Martins de Barros, Karina Kimiko Yamashina Pereira, Giovanna Iezzi, and Adriano Piattelli. "Influence of implant surfaces on osseointegration." Brazilian Dental Journal 21, no. 6 (2010): 471–81. http://dx.doi.org/10.1590/s0103-64402010000600001.
Повний текст джерелаАнотація:
The biological fixation between the dental implant surfaces and jaw bones should be considered a prerequisite for the long-term success of implant-supported prostheses. In this context, the implant surface modifications gained an important and decisive place in implant research over the last years. As the most investigated topic in, it aided the development of enhanced dental treatment modalities and the expansion of dental implant use. Nowadays, a large number of implant types with a great variety of surface properties and other features are commercially available and have to be treated with caution. Although surface modifications have been shown to enhance osseointegration at early implantation times, for example, the clinician should look for research evidence before selecting a dental implant for a specific use. This paper reviews the literature on dental implant surfaces by assessing in vitro and in vivo studies to show the current perspective of implant development. The review comprises quantitative and qualitative results on the analysis of bone-implant interface using micro and nano implant surface topographies. Furthermore, the perspective of incorporating biomimetic molecules (e.g.: peptides and bone morphogenetic proteins) to the implant surface and their effects on bone formation and remodeling around implants are discussed.
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Kausher, Hina, and Devendra PS Chonkkar. "An Insight into the Surface of Dental Implants." Journal of Mahatma Gandhi University of Medical Sciences and Technology 2, no. 1 (2017): 23–28. http://dx.doi.org/10.5005/jp-journals-10057-0026.
Повний текст джерелаАнотація:
ABSTRACT Osseointegration, the direct contact between living bone and the surface of load-carrying implant, is imperative for the long-term success of dental implants. There is no distinct relationship between osseointegration and defined surface characteristics, since a great number of different surfaces achieve osseointegration. However, the rate, extent, and the strength of this connection may be dependent on the surface characteristics of the implant. The aim of this article was to review the literature on the various approaches available to modify the bone–implant interface. How to cite this article Kausher H, Padiyar N, Kaurani P, Meena S, Chonkkar DPS. An Insight into the Surface of Dental Implants. J Mahatma Gandhi Univ Med Sci Tech 2017;2(1):23-28.
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Ballini, Andrea, Apollonia Desiate, and Stefania Cantore. "In vitro Comparison between Two Different Implant Titanium Surfaces in Osseointegration Process." International Journal of Experimental Dental Science 1, no. 2 (2012): 84–88. http://dx.doi.org/10.5005/jp-journals-10029-1021.
Повний текст джерелаАнотація:
ABSTRACT The osseointegration rate of titanium dental implants is related to their composition and surface roughness. Rough-surfaced implants favor both bone anchoring and biomechanical stability. The future of dental implantology should aim to develop surfaces with controlled and standardized topography or chemistry. This approach will be the only way to understand the interactions between proteins, cells and tissues and implant surfaces. The local release of bone stimulating or resorptive drugs in the peri-implant region may also respond to difficult clinical situations with poor bone quality and quantity, such as implant design and surface. These therapeutic strategies should ultimately enhance the osseointegration process of dental implants for their immediate loading and long-term success. Aim of this work was to compare implant titanium surfaces prepared with two different topographies for evaluating osteoblasts adhesion and growth. How to cite this article Ballini A, Desiate A, Cantore S. In vitro Comparison between Two Different Implant Titanium Surfaces in Osseointegration Process. Int J Experiment Dent Sci 2012; 1(2):84-88.
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López-Valverde, Nansi, Javier Flores-Fraile, Juan Manuel Ramírez, Bruno Macedo de Sousa, Silvia Herrero-Hernández, and Antonio López-Valverde. "Bioactive Surfaces vs. Conventional Surfaces in Titanium Dental Implants: A Comparative Systematic Review." Journal of Clinical Medicine 9, no. 7 (June 29, 2020): 2047. http://dx.doi.org/10.3390/jcm9072047.
Повний текст джерелаАнотація:
Animal studies and the scarce clinical trials available that have been conducted suggest that bioactive surfaces on dental implants could improve the osseointegration of such implants. The purpose of this systematic review was to compare the effectiveness of osseointegration of titanium (Ti) dental implants using bioactive surfaces with that of Ti implants using conventional surfaces such as sandblasted large-grit acid-etched (SLA) or similar surfaces. Applying the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statement, the MEDLINE, PubMed Central and Web of Science databases were searched for scientific articles in April 2020. The keywords used were “dental implants”, “bioactive surfaces”, “biofunctionalized surfaces”, and “osseointegration”, according to the question: “Do bioactive dental implant surfaces have greater osseointegration capacity compared with conventional implant surfaces?” Risk of bias was assessed using the Cochrane Collaboration tool. 128 studies were identified, of which only 30 met the inclusion criteria: 3 clinical trials and 27 animal studies. The average STROBE (STrengthening the Reporting of OBservational studies in Epidemiology) and ARRIVE (Animal Research: Reporting of In Vivo Experiments) scores were 15.13 ± 2.08 and 17.7±1.4, respectively. Implant stability quotient (ISQ) was reported in 3 studies; removal torque test (RTT)—in 1 study; intraoral periapical X-ray and microcomputed tomography radiological evaluation (RE)—in 4 studies; shear force (SF)—in 1 study; bone-to-implant contact (BIC)—in 12 studies; and BIC and bone area (BA) jointly—in 5 studies. All animal studies reported better bone-to-implant contact surface for bioactive surfaces as compared to control implants with a statistical significance of p < 0.05. Regarding the bioactive surfaces investigated, the best results were yielded by the one where mechanical and chemical treatment methods of the Ti surfaces were combined. Hydroxyapatite (HA) and calcium–phosphate (Ca–Ph) were the most frequently used bioactive surfaces. According to the results of this systematic review, certain bioactive surfaces have a positive effect on osseointegration, although certain coating biomolecules seem to influence early peri-implant bone formation. Further and more in-depth research in this field is required to reduce the time needed for osseointegration of dental implants.
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Saksø, Mikkel, Stig S. Jakobsen, Henrik Saksø, Jørgen Baas, Thomas Jakobsen, and Kjeld Søballe. "Acid Etching and Plasma Sterilization Fail to Improve Osseointegration of Grit Blasted Titanium Implants." Open Orthopaedics Journal 6, no. 1 (September 3, 2012): 376–82. http://dx.doi.org/10.2174/1874325001206010376.
Повний текст джерелаАнотація:
Interaction between implant surface and surrounding bone influences implant fixation. We attempted to improve the bone-implant interaction by 1) adding surface micro scale topography by acid etching, and 2) removing surface-adherent pro-inflammatory agents by plasma cleaning. Implant fixation was evaluated by implant osseointegration and biomechanical fixation. The study consisted of two paired animal sub-studies where 10 skeletally mature Labrador dogs were used. Grit blasted titanium alloy implants were inserted press fit in each proximal tibia. In the first study grit blasted implants were compared with acid etched grit blasted implants. In the second study grit blasted implants were compared with acid etched grit blasted implants that were further treated with plasma sterilization. Implant performance was evaluated by histomorphometrical investigation (tissue-to-implant contact, peri-implant tissue density) and mechanical push-out testing after four weeks observation time. Neither acid etching nor plasma sterilization of the grit blasted implants enhanced osseointegration or mechanical fixation in this press-fit canine implant model in a statistically significant manner.
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Yin, Xing, Jingtao Li, Waldemar Hoffmann, Angelines Gasser, John Brunski, and Jill Helms. "Mechanical and Biological Advantages of a Tri-Oval Implant Design." Journal of Clinical Medicine 8, no. 4 (March 28, 2019): 427. http://dx.doi.org/10.3390/jcm8040427.
Повний текст джерелаАнотація:
Of all geometric shapes, a tri-oval one may be the strongest because of its capacity to bear large loads with neither rotation nor deformation. Here, we modified the external shape of a dental implant from circular to tri-oval, aiming to create a combination of high strain and low strain peri-implant environment that would ensure both primary implant stability and rapid osseointegration, respectively. Using in vivo mouse models, we tested the effects of this geometric alteration on implant survival and osseointegration over time. The maxima regions of tri-oval implants provided superior primary stability without increasing insertion torque. The minima regions of tri-oval implants presented low compressive strain and significantly less osteocyte apoptosis, which led to minimal bone resorption compared to the round implants. The rate of new bone accrual was also faster around the tri-oval implants. We further subjected both round and tri-oval implants to occlusal loading immediately after placement. In contrast to the round implants that exhibited a significant dip in stability that eventually led to their failure, the tri-oval implants maintained their stability throughout the osseointegration period. Collectively, these multiscale biomechanical analyses demonstrated the superior in vivo performance of the tri-oval implant design.
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Al-Hezaimi, Khalid, Myron Nevins, Soo-Woo Kim, Ardavan Fateh, and David M. Kim. "Efficacy of Growth Factor in Promoting Early Osseointegration." Journal of Oral Implantology 40, no. 5 (October 1, 2014): 543–48. http://dx.doi.org/10.1563/aaid-joi-d-13-00304.
Повний текст джерелаАнотація:
A preclinical study was conducted to evaluate the feasibility of 2 different topical formulations of recombinant human platelet-derived growth factor-BB (rhPDGF-BB) to promote early osseointegration and enhanced bone-to-implant contact (BIC) for dental implants placed in an edentulous ridge. Six female beagle dogs were divided into 3 groups. The control group included 4 implants with no coating; test group A included 10 implants with commercially available rhPDGF-BB formulation coating; and second test group B included 10 implants with prototype viscous rhPDGF-BB coating. Three dogs were sacrificed at 3 weeks (12 implants) and the remaining 3 dogs at 6 weeks after implant placement (12 implants). The specimens were retrieved for histological evaluation, and revealed an uneventful healing of all implants without any sign of an inflammatory response at the different time intervals. Furthermore, the bone was in very close contact with the implants' surfaces with no evidence of intervening fibrous tissue layers. At 3 weeks, new bone formation between most implant threads on rhPDGF-BB coated implants was evident, whereas in the control group only a thin and sparse amount of new bone was noted. At 6 weeks, the commercially available rhPDGF-BB formulation coated implant group (Group A) showed more trabecular bone and higher BIC compared to the other 2 groups. Histologically, the results in this study showed that use of conventionally available rhPDGF-BB formulation as the implant surface treatment may accelerate the process of osseointegration and enhance BIC.
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Vien, Benjamin Steven, Wing Kong Chiu, Matthias Russ, and Mark Fitzgerald. "A Quantitative Approach for the Bone-implant Osseointegration Assessment Based on Ultrasonic Elastic Guided Waves." Sensors 19, no. 3 (January 22, 2019): 454. http://dx.doi.org/10.3390/s19030454.
Повний текст джерелаАнотація:
Quantitative and reliable monitoring of osseointegration will help further evaluate the integrity of the orthopaedic construct to promote novel prosthesis design and allow early mobilisation. Quantitative assessment of the degree or the lack of osseointegration is important for the clinical management with the introduction of prosthetic implants to amputees. Acousto-ultrasonic wave propagation has been used in structural health monitoring as well as human health monitoring but so far has not extended to osseointegrated implants or prostheses. This paper presents an ultrasonic guided wave approach to assess the osseointegration of a novel implant. This study explores the potential of integrating structural health monitoring concepts into a new osseointegrated implant. The aim is to demonstrate the extension of acousto-ultrasonic techniques, which have been widely reported for the structural health monitoring of engineering structures, to assess the state of osseointegration of a bone and implant. To illustrate this potential, this paper will report on the experimental findings which investigated the unification of an aluminium implant and bone-like geometry surrogate. The core of the test specimen is filled with silicone and wrapped with plasticine to simulate the highly damped cancellous bone and soft tissue, respectively. To simulate the osseointegration process, a 2-h adhesive epoxy is used to bond the surrogate implant and a bone-like structure. A series of piezoelectric elements are bonded onto the surrogate implant to serve as actuators and sensors. The actuating piezoelectric element on an extramedullary strut is excited with a 1 MHz pulse signal. The reception of the ultrasonic wave by the sensing elements located on the adjacent and furthest struts is used to assess the integration of this implant to the parent bone structure. The study shows an Osseointegration Index can be formulated by using engineering and acousto-ultrasonic methods to measure the unification of a bone and implant. This also highlights a potential quantitative evaluation technique regardless of bone-implant geometry and soft tissue damping.
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Jakobsen, Thomas, Søren Kold, Jørgen Baas, Kjeld Søballe, and Ole Rahbek. "Sheep Hip Arthroplasty Model of Failed Implant Osseointegration." Open Orthopaedics Journal 9, no. 1 (November 13, 2015): 525–29. http://dx.doi.org/10.2174/1874325001509010525.
Повний текст джерелаАнотація:
Early secure stability of an implant is important for long-term survival. We examined whether micromotion of implants consistently would induce bone resorption and formation of a fibrous membrane and thereby prevent osseointegration.One micromotion implant was inserted into one of the medial femoral condyles in ten sheep. The micromotion device consists of an anchor bearing a PMMA implant and a PE plug. During each gait cycle the PE plug will make the PMMA implant axially piston 0.5 mm. After 12 weeks of observation the bone specimens were harvested and a post-mortem control implant was inserted into the contra-lateral medial femoral condyle.Histomorphometrical evaluation showed that the surface on the implant observed for 12 weeks was covered by fibrous tissue. The control implants were covered by lamellar bone. No difference was found with respect to the volume fraction of lamellar bone in a 1 mm zone around the implants.This study indicates that implant micromotion is sufficient to induce bone resorption and formation of a fibrous membrane.
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Keuroghlian, Armand, Ana Dilza Viana Barroso, Gary Kirikian, Olga Bezouglaia, Yin Tintut, Sotirios Tetradis, Peter Moy, Flavia Pirih, and Tara Aghaloo. "The Effects of Hyperlipidemia on Implant Osseointegration in the Mouse Femur." Journal of Oral Implantology 41, no. 2 (April 1, 2015): e7-e11. http://dx.doi.org/10.1563/aaid-joi-d-13-00105.
Повний текст джерелаАнотація:
A high-fat (HF) diet inducing hyperlipidemia has been associated with the pathophysiology of major diseases, such as atherosclerosis and osteoporosis. A HF diet has significant adverse effects on bone, including lower bone density, volume, and strength. Statins, drugs that lower serum cholesterol levels have beneficial effects on bone metabolism. Since the host's bone quantity, quality, and healing potential play a crucial role in osseointegration of dental implants, we hypothesized that hyperlipidemia may negatively affect implant osseointegration. In the present study, we evaluated the effects of hyperlipidemia on implant osseointegration in mice. Atherosclerosis susceptible C57BL/6J male mice were randomly placed on a control chow or a HF diet. After 12 weeks on the diet, each mouse received a titanium implant in the proximal metaphysis of the femur. The animals were humanely killed at 4 or 8 weeks after the implant surgery. Results showed that the mice fed a HF diet had significantly increased implant loss as well as decreased formation and strength of bone-to-implant interface. These results support the hypothesis that a HF diet can significantly compromise osseointegration, causing poor outcome in dental implant therapy.
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Brizuela-Velasco, Aritza, Esteban Pérez-Pevida, Antonio Jiménez-Garrudo, Francisco Javier Gil-Mur, José María Manero, Miquel Punset-Fuste, David Chávarri-Prado, Markel Diéguez-Pereira, and Francesca Monticelli. "Mechanical Characterisation and Biomechanical and Biological Behaviours of Ti-Zr Binary-Alloy Dental Implants." BioMed Research International 2017 (2017): 1–10. http://dx.doi.org/10.1155/2017/2785863.
Повний текст джерелаАнотація:
The objective of the study is to characterise the mechanical properties of Ti-15Zr binary alloy dental implants and to describe their biomechanical behaviour as well as their osseointegration capacity compared with the conventional Ti-6Al-4V (TAV) alloy implants. The mechanical properties of Ti-15Zr binary alloy were characterised using Roxolid© implants (Straumann, Basel, Switzerland) via ultrasound. Their biomechanical behaviour was described via finite element analysis. Their osseointegration capacity was compared via an in vivo study performed on 12 adult rabbits. Young’s modulus of the Roxolid© implant was around 103 GPa, and the Poisson coefficient was around 0.33. There were no significant differences in terms of Von Mises stress values at the implant and bone level between both alloys. Regarding deformation, the highest value was observed for Ti-15Zr implant, and the lowest value was observed for the cortical bone surrounding TAV implant, with no deformation differences at the bone level between both alloys. Histological analysis of the implants inserted in rabbits demonstrated higher BIC percentage for Ti-15Zr implants at 3 and 6 weeks. Ti-15Zr alloy showed elastic properties and biomechanical behaviours similar to TAV alloy, although Ti-15Zr implant had a greater BIC percentage after 3 and 6 weeks of osseointegration.
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Sun, Ruoyue, Yaru Yang, Yanshu Ding, Jingwen Zhuang, Jingyuan Cui, and Long Bai. "Nervous System-Driven Osseointegration." International Journal of Molecular Sciences 23, no. 16 (August 10, 2022): 8893. http://dx.doi.org/10.3390/ijms23168893.
Повний текст джерелаАнотація:
Implants are essential therapeutic tools for treating bone fractures and joint replacements. Despite the in-depth study of osseointegration for more than fifty years, poor osseointegration caused by aseptic loosening remains one of the leading causes of late implant failures. Osseointegration is a highly sophisticated and spatiotemporal process in vivo involving the immune response, angiogenesis, and osteogenesis. It has been unraveled that the nervous system plays a pivotal role in skeletal health via manipulating neurotrophins, neuropeptides, and nerve cells. Herein, the research related to nervous system-driven osseointegration was systematically analyzed and reviewed, aiming to demonstrate the prominent role of neuromodulation in osseointegration. Additionally, it is indicated that the implant design considering the role of neuromodulation might be a promising way to prevent aseptic loosening.
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Khwaja, S., A. Curry, I. H. Chaudhry, and K. M. J. Green. "Can keratinocytes cause failure of osseointegration?" Journal of Laryngology & Otology 123, no. 9 (December 9, 2008): 1035–38. http://dx.doi.org/10.1017/s002221510800409x.
Повний текст джерелаАнотація:
AbstractAim:Bone-anchored hearing aids are well established, implanted devices. We present two patients who suffered mixed hearing loss and who underwent titanium implant placement in the temporal bone to enable attachment of bone-anchored hearing aids. Osseointegration is necessary for such implants to function. We report these two cases to highlight how such osseointegration may be disrupted.Method:Attached tissue from the explanted or removed titanium implants was examined by transmission electron microscopy and histopathological analysis.Results:Attached tissue from both implants showed the presence of keratinocytes at the titanium implant and living bone interface. This was confirmed by histopathological analysis. In one case, there was frank keratinocyte proliferation, which had led to osseointegration failure; in the other case, such proliferation was present but not so advanced.Conclusion:These findings suggest that, in the cases reported, keratinocytes implanted between the titanium and the living bone, leading to disruption of osseointegration.
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Sui, Junhao, Shu Liu, Mengchen Chen, and Hao Zhang. "Surface Bio-Functionalization of Anti-Bacterial Titanium Implants: A Review." Coatings 12, no. 8 (August 5, 2022): 1125. http://dx.doi.org/10.3390/coatings12081125.
Повний текст джерелаАнотація:
Titanium (Ti) and titanium alloy have been widely used in orthopedics. However, the successful application of titanium implants is mainly limited due to implant-associated infections. The implant surface contributes to osseointegration, but also has the risk of accelerating the growth of bacterial colonies, and the implant surfaces infected with bacteria easily form biofilms that are resistant to antibiotics. Biofilm-related implant infections are a disastrous complication of trauma orthopedic surgery and occur when an implant is colonized by bacteria. Surface bio-functionalization has been extensively studied to better realize the inhibition of bacterial proliferation to further optimize the mechanical functions of implants. Recently, the surface bio-functionalization of titanium implants has been presented to improve osseointegration. However, there are still numerous clinical and non-clinical challenges. In this review, these aspects were highlighted to develop surface bio-functionalization strategies for enhancing the clinical application of titanium implants to eliminate implant-associated infections.
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Kayacan, Mehmet C., Yakup B. Baykal, Tamer Karaaslan, Koray Özsoy, İlker Alaca, Burhan Duman, and Yunus E. Delikanlı. "Monitoring the osseointegration process in porous Ti6Al4V implants produced by additive manufacturing: an experimental study in sheep." Journal of Applied Biomaterials & Functional Materials 16, no. 2 (November 13, 2017): 68–75. http://dx.doi.org/10.5301/jabfm.5000385.
Повний текст джерелаАнотація:
Background: This study investigated the design and osseointegration process of transitive porous implants that can be used in humans and all trabecular and compact bone structure animals. The aim was to find a way of forming a strong and durable tissue bond on the bone–implant interface. Methods: Massive and transitive porous implants were produced on a direct metal laser sintering machine, surgically implanted into the skulls of sheep and kept in place for 12 weeks. At the end of the 12-week period, the Massive and porous implants removed from the sheep were investigated by scanning electron microscopy (SEM) to monitor the osseointegration process. Results: In the literature, each study has selected standard sizes for pore diameter in the structures they use. However, none of these involved transitional porous structures. In this study, as opposed to standard pores, there were spherical or elliptical pores at the micro level, development channels and an inner region. Bone cells developed in the inner region. Transitive pores grown gradually in accordance with the natural structure of the bone were modeled in the inner region for cells to develop. Due to this structure, a strong and durable tissue bond could be formed at the bone–implant interface. Conclusions: Osseointegration processes of Massive vs. porous implants were compared. It was observed that cells were concentrated on the surface of Massive implants. Therefore, osseointegration between implant and bone was less than that of porous implants. In transitive porous implants, as opposed to Massive implants, an outer region was formed in the bone–implant interface that allowed tissue development.
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Anitua, Eduardo A. "Enhancement of Osseointegration by Generating a Dynamic Implant Surface." Journal of Oral Implantology 32, no. 2 (April 1, 2006): 72–76. http://dx.doi.org/10.1563/736.1.
Повний текст джерелаАнотація:
Abstract Preparations of autologous plasma rich in growth factors (PRGF) are used to promote healing and tissue regeneration. We seek to determine whether covering the titanium implant surface with this preparation could enhance osseointegration. The interaction of PRGF with the surface of titanium implants was examined by environmental scanning electron microscopy (ESEM). A total of 23 implants were placed in the tibiae and radii of 3 goats; 13 implants were inserted after covering the surface and filling the alveolus with PRGF, and 10 more implants were inserted following a conventional protocol and served as controls. Histomorphometric analysis of the bone-implant interface was performed after 8 weeks. Finally, 1391 implants were placed in 295 patients after bioactivating the surface with PRGF. Stability and implant survival were evaluated. The implant surface adsorbed the protein-rich material as shown by ESEM. In the animal study, osseointegration was enhanced when the surface was covered with PRGF as shown by histomorphometry (bone-implant contact: 51.28% ± 4.7% vs 21.89% ± 7.36%; P < .01). Finally, studies in patients showed that 99.6% of the implants treated with PRGF were well osseointegrated. Clinical use of this technique in oral implantology can improve the prognosis.
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Махмудов, Тофик, and Tofik Mahmudov. "ESTIMATION OF THE COMPOSITION OF MICROBIOTES OF PERIIMPLANT FURROWS IN THE PROCESS OF OSTEOINTEGRATION OF DENTAL IMPLANTS." Actual problems in dentistry 15, no. 3 (October 25, 2019): 158–63. http://dx.doi.org/10.18481/2077-7566-2019-15-3-158-163.
Повний текст джерелаАнотація:
Background. The necessity of studying the microbiota of the oral cavity, as one of the main causes of complications after the installation of dental implants, is considered. In the dynamics of osseointegration of dental implants (1-6-12 months), a study was made of the species and quality composition of the microbiota of peri-implant and gingival furrows.
Objectives ― to study the composition of microbiota in the gingival sulcus of an adjacent healthy tooth and the peri-implant sulcus of the implant in the process of osseointegration of dental implants.
Methods. A microbiological study of the composition of the microbiota of the studied biotopes — the peri-implant sulcus and gingival sulcus of an adjacent healthy tooth in the process of osseointegration of dental implants in 83 patients was carried out. The total number of bacteria was detected by real-time polymerase chain reaction.
Results. 1 month after the installation of dental implants and fixation of the Treponema denticola gingival former in the samples from the gingival sulcus of the tooth was 16.03 %, and the number of Tannerella forsythensis was 5.52 % higher than in the samples from the peri-implant sulcus. After 6 months, the total bacterial mass in the peri-implant sulcus was 12.7 % less. The amounts of Prevotella intermedia, Treponema denticola, Tannerella forsythensis and Porphyromorans gingivalis in the peri-implant groove decreased by 2.9, 6.1, 5.2 and 11.6 %, respectively. After 12 months, a statistically significant decrease in Porphyromorans gingivalis was observed 2.7 times (p <0.01) and 2.6 times (p <0.01), respectively, in the peri-implant and gingival sulcus.
Conclusions. In the process of osseointegration of dental implants, the total bacterial mass (p <0.01), Porphyromorans gingivalis (p <0.01) decreased dynamically, statistically significantly, the number of Tannerella forsythensis increased (p <0.05). Also dynamically, but slightly, a decrease in Candida albicans was observed. After 12 months, an accumulation of Prevotella intermediaries was observed at the implantation sites.
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Dergin, Guhan, Mustafa Akta, Bahar Gürsoy, Yalçin Devecioglu, Mehmet Kürkçü, and Emre Benlidayi. "Direct Current Electric Stimulation in Implant Osseointegration: An Experimental Animal Study With Sheep." Journal of Oral Implantology 39, no. 6 (December 1, 2013): 671–79. http://dx.doi.org/10.1563/aaid-joi-d-10-00172.
Повний текст джерелаАнотація:
In an effort to obtain a high-quality bone-implant interface, several methods involving alteration of surface morphological, physicochemical, and biochemical properties are being investigated. The aim of our study was to increase the osseointegration rate and quality and decrease the waiting period of dental implants before loading by using a microelectric implant stimulator device. It imitates microelectrical signals, which occur in bone fractures described in terms of piezoelectric theory. A single dental implant (Zimmer Dental), 3.7 mm in diameter, was inserted into the tibia of sheep bilaterally. Twenty-four dental implants were inserted into 12 sheep. Implant on the tibia of each sheep was stimulated with 7.5 μA direct current (DC), while the other side did not receive any stimulation and served as a control. Animals were sacrificed 1, 2, and 3 months after implantation. Bone segments with implants were processed with unclassified method. The determination of new bone formation and osseointegration around the dental implants was investigated by means of undecalcified method, histomorphologically. No statistically significant difference in bone-to-implant contact (BIC) ratio, osteoblastic activity, and new bone formation was found between the stimulation group and the control group at the late phase of healing (4, 8, and 12 weeks). No evidence was found that electric stimulation with implanted 7.5 μA DC is effective at late phase implant osseointegration on a sheep experimental model.
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Swarna Meenakshi, P. "A review on ozone therapy in periodontitis." Bioinformation 18, no. 7 (July 31, 2022): 634–39. http://dx.doi.org/10.6026/97320630018634.
Повний текст джерелаАнотація:
The biologic process of osseointegration (bone to implant interface), in which the implant forms an intimate relationship with the bone, provides the foundation for modern dental implants. Osseointegration necessitates a varying length of healing time. Despite the high success and survival rates of dental implants, problems do occur, necessitating ongoing periodontal and prosthodontic care. This failure frequently results in "peri-implantitis," which affects the soft and hard tissues surrounding the osseointegrated implants, resulting in the formation of a peri implant pocket and bone loss. Decontamination is a difficult feature of surgical regenerative therapy for peri-implantitis that has an impact on its success. Because microbial biofilms play such a significant part in the aetiology of peri-implant illnesses, it has long been assumed that eliminating microbial pathogens would be beneficial.
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Meng, Fanying, Zhifeng Yin, Xiaoxiang Ren, Zhen Geng, and Jiacan Su. "Construction of Local Drug Delivery System on Titanium-Based Implants to Improve Osseointegration." Pharmaceutics 14, no. 5 (May 17, 2022): 1069. http://dx.doi.org/10.3390/pharmaceutics14051069.
Повний текст джерелаАнотація:
Titanium and its alloys are the most widely applied orthopedic and dental implant materials due to their high biocompatibility, superior corrosion resistance, and outstanding mechanical properties. However, the lack of superior osseointegration remains the main obstacle to successful implantation. Previous traditional surface modification methods of titanium-based implants cannot fully meet the clinical needs of osseointegration. The construction of local drug delivery systems (e.g., antimicrobial drug delivery systems, anti-bone resorption drug delivery systems, etc.) on titanium-based implants has been proved to be an effective strategy to improve osseointegration. Meanwhile, these drug delivery systems can also be combined with traditional surface modification methods, such as anodic oxidation, acid etching, surface coating technology, etc., to achieve desirable and enhanced osseointegration. In this paper, we review the research progress of different local drug delivery systems using titanium-based implants and provide a theoretical basis for further research on drug delivery systems to promote bone–implant integration in the future.
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Nastri, Livia, Antimo Moretti, Silvia Migliaccio, Marco Paoletta, Marco Annunziata, Sara Liguori, Giuseppe Toro, et al. "Do Dietary Supplements and Nutraceuticals Have Effects on Dental Implant Osseointegration? A Scoping Review." Nutrients 12, no. 1 (January 20, 2020): 268. http://dx.doi.org/10.3390/nu12010268.
Повний текст джерелаАнотація:
Several factors affect dental implant osseointegration, including surgical issues, bone quality and quantity, and host-related factors, such as patients’ nutritional status. Many micronutrients might play a key role in dental implant osseointegration by influencing some alveolar bone parameters, such as healing of the alveolus after tooth extraction. This scoping review aims to summarize the role of dietary supplements in optimizing osseointegration after implant insertion surgery. A technical expert panel (TEP) of 11 medical specialists with expertise in oral surgery, bone metabolism, nutrition, and orthopedic surgery performed the review following the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews) model. The TEP identified micronutrients from the “European Union (EU) Register of nutrition and health claims made on foods” that have a relationship with bone and tooth health, and planned a PubMed search, selecting micronutrients previously identified as MeSH (Medical Subject Headings) terms and adding to each of them the words “dental implants” and “osseointegration”. The TEP identified 19 studies concerning vitamin D, magnesium, resveratrol, vitamin C, a mixture of calcium, magnesium, zinc, and vitamin D, and synthetic bone mineral. However, several micronutrients are non-authorized by the “EU Register on nutrition and health claims” for improving bone and/or tooth health. Our scoping review suggests a limited role of nutraceuticals in promoting osseointegration of dental implants, although, in some cases, such as for vitamin D deficiency, there is a clear link among their deficit, reduced osseointegration, and early implant failure, thus requiring an adequate supplementation.
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Stefano, Danilo Di, Giovanna Iezzi, Antonio Scarano, Vittoria Perrotti, and Adriano Piattelli. "Immediately Loaded Blade Implant Retrieved From a Man After a 20-year Loading Period: A Histologic and Histomorphometric Case Report." Journal of Oral Implantology 32, no. 4 (August 1, 2006): 171–76. http://dx.doi.org/10.1563/765.1.
Повний текст джерелаАнотація:
Abstract Immediate loading of root-form dental implants has shown promising results and offers treatment cost and convenience advantages to patients. Although blade implants have been immediately loaded for over 2 decades, the ability of this implant design to achieve osseointegration has been debated. The aim of the present study was to histologically evaluate the peri-implant tissues of an immediately loaded blade implant retrieved for abutment fracture after a 20-year loading period. Histologic samples were prepared and examined by light microscope. Compact, cortical, mature bone with well-formed osteons was present at the interface of the implant. Bone-to-implant contact was 51% ± 6%. The histologic data showed that osseointegration was obtained in an immediately loaded blade implant inserted into the mandible, and that mineralized tissues were maintained at the interface over a long period (20 years).
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Yuan, X., X. Pei, Y. Zhao, Z. Li, C. H. Chen, U. S. Tulu, B. Liu, L. A. Van Brunt, J. B. Brunski, and J. A. Helms. "Biomechanics of Immediate Postextraction Implant Osseointegration." Journal of Dental Research 97, no. 9 (April 2, 2018): 987–94. http://dx.doi.org/10.1177/0022034518765757.
Повний текст джерелаАнотація:
The aim of this study was to gain insights into the biology and mechanics of immediate postextraction implant osseointegration. To mimic clinical practice, murine first molar extraction was followed by osteotomy site preparation, specifically in the palatal root socket. The osteotomy was positioned such that it removed periodontal ligament (PDL) only on the palatal aspect of the socket, leaving the buccal aspect undisturbed. This strategy created 2 distinct peri-implant environments: on the palatal aspect, the implant was in direct contact with bone, while on the buccal aspect, a PDL-filled gap existed between the implant and bone. Finite element modeling showed high strains on the palatal aspect, where bone was compressed by the implant. Osteocyte death and bone resorption predominated on the palatal aspect, leading to the loss of peri-implant bone. On the buccal aspect, where finite element modeling revealed low strains, there was minimal osteocyte death and robust peri-implant bone formation. Initially, the buccal aspect was filled with PDL remnants, which we found directly provided Wnt-responsive cells that were responsible for new bone formation and osseointegration. On the palatal aspect, which was devoid of PDL and Wnt-responsive cells, adding exogenous liposomal WNT3A created an osteogenic environment for rapid peri-implant bone formation. Thus, we conclude that low strain and high Wnt signaling favor osseointegration of immediate postextraction implants. The PDL harbors Wnt-responsive cells that are inherently osteogenic, and if the PDL tissue is healthy, it is reasonable to preserve this tissue during immediate implant placement.
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Shibli, Jamil Awad, Magda Feres, Luciene Cristina de Figueiredo, Giovanna Iezzi, and Adriano Piattelli. "Histological Comparison of Bone to Implant Contact in Two Types of Dental Implant Surfaces: A Single Case Study." Journal of Contemporary Dental Practice 8, no. 3 (2007): 29–36. http://dx.doi.org/10.5005/jcdp-8-3-29.
Повний текст джерелаАнотація:
Abstract Aim The purpose of this single case study was to evaluate the influence of different implant surfaces on human bone and osseointegration. Methods and Materials A 47-year-old partially edentulous woman received two experimental implants along with conventional implant therapy. Experimental implants placed in the mandibular ramus consisted of machined and anodized surfaces, respectively. After three months of healing, the experimental implants were removed and prepared for ground sectioning and histological analysis. Results The data demonstrate anodized implant surfaces present a higher percentage of osseointegration when compared to a machined surface in cortical human bone after a healing period of three months. Conclusion This single case study suggests an anodized implant surface results in a higher percentage of bone to implant contact when compared to machined surfaced implants when placed in dense bone tissue. However, further investigations should be conducted. Citation Shibli JA, Feres M, de Figueiredo LC, Iezzi G, Piattelli A. Histological Comparison of Bone to Implant Contact in Two Types of Dental Implant Surfaces: A Single Case Study. J Contemp Dent Pract 2007 March;(8)3:029-036.
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Anitua, Eduardo, Alia Murias-Freijo, Laura Piñas, Ricardo Tejero, Roberto Prado, and Gorka Orive. "Nontraumatic Implant Explantation: A Biomechanical and Biological Analysis in Sheep Tibia." Journal of Oral Implantology 42, no. 1 (February 1, 2016): 3–11. http://dx.doi.org/10.1563/aaid-joi-d-14-00193.
Повний текст джерелаАнотація:
Preclinical research in a sheep tibia model has been conducted to evaluate the underlying mechanisms of the nontraumatic implant explantation of failed implants, which allow placing a new one in the bone bed. Twelve dental implants were placed in sheep diaphysis tibia and once osseointegrated they were explanted using a nontraumatic implant explantation approach. Implant osseointegration and explantation were monitored by means of frequency resonance, removal torque, and angle of rotation measurement. The host bone bed and the explanted implant surface were analyzed by conventional microscopy and scanning electron microscope. Results show that osseointegration was broken with an angular displacement of less than 20°. In this situation the implant returns to implant stability quotient values in the same range of their primary stability. Moreover, the explantation technique causes minimal damage to the surrounding bone structure and cellularity. This nontraumatic approach allows the straightforward replacement of failed implants and emerges as a promising strategy to resolve clinically challenging situations.
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Han, Wen, Shuobo Fang, Qun Zhong, and Shengcai Qi. "Influence of Dental Implant Surface Modifications on Osseointegration and Biofilm Attachment." Coatings 12, no. 11 (October 31, 2022): 1654. http://dx.doi.org/10.3390/coatings12111654.
Повний текст джерелаАнотація:
Dental implants have been widely applied in partially and fully edentulous patients and have shown predictable clinical outcomes, but there are still many cases of implant failures, such as osseointegration failure and peri-implant inflammation. To improve the success rate of implants, especially in improving osseointegration and antibacterial performance, various methods of implant surface modification have been applied. Surface modification methods covered include sandblasting with large-grit corundum and acid etched (SLA), plasma spraying, plasma immersion ion implantation (PIII), sputter-deposition, selective laser melting (SLM), anodic oxidation, microarc oxidation, sol-gel coating, alkaline heat treatment (AH) and Layer-by-Layer (LBL) self-assembly. This review comprehensively summarizes the influence of each method on osseointegration and biofilm attachment. The mechanical, chemical and biological disadvantages of these methods are involved. Besides, the mechanisms behind such techniques as increasing surface roughness to expand superficial area and enhance the adhesion of osteoblastic cells are discussed.
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Velasco-Ortega, Eugenio, Iván Ortiz-Garcia, Alvaro Jiménez-Guerra, Enrique Núñez-Márquez, Jesús Moreno-Muñoz, José Luis Rondón-Romero, Daniel Cabanillas-Balsera, Javier Gil, Fernando Muñoz-Guzón, and Loreto Monsalve-Guil. "Osseointegration of Sandblasted and Acid-Etched Implant Surfaces. A Histological and Histomorphometric Study in the Rabbit." International Journal of Molecular Sciences 22, no. 16 (August 7, 2021): 8507. http://dx.doi.org/10.3390/ijms22168507.
Повний текст джерелаАнотація:
Titanium surface is an important factor in achieving osseointegration during the early wound healing of dental implants in alveolar bone. The purpose of this study was to evaluate sandblasted-etched surface implants to investigate the osseointegration. In the present study, we used two different types of sandblasted-etched surface implants, an SLA™ surface and a Nanoblast Plus™ surface. Roughness and chemical composition were evaluated by a white light interferometer microscope and X-ray photoelectron spectroscopy, respectively. The SLA™ surface exhibited the higher values (Ra 3.05 μm) of rugosity compared to the Nanoblast Plus™ surface (Ra 1.78 μm). Both types of implants were inserted in the femoral condyles of ten New Zealand white rabbits. After 12 weeks, histological and histomorphometric analysis was performed. All the implants were osseointegrated and no signs of infection were observed. Histomorphometric analysis revealed that the bone–implant contact % (BIC) ratio was similar around the SLA™ implants (63.74 ± 13.61) than around the Nanoblast Plus™ implants (62.83 ± 9.91). Both implant surfaces demonstrated a favorable bone response, confirming the relevance of the sandblasted-etched surface on implant osseointegration.
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Adam, Martin, Cornelia Ganz, Wei Guo Xu, Hamit R. Sarajian, Bernhard Frerich, and Thomas Gerber. "How to Enhance Osseointegration – Roughness, Hydrophilicity or Bioactive Coating." Key Engineering Materials 493-494 (October 2011): 467–72. http://dx.doi.org/10.4028/www.scientific.net/kem.493-494.467.
Повний текст джерелаАнотація:
The apposition of bone at early stages is critical for rapid loading and therefore there is much effort in improving the implant surfaces for a rapid osseointegration. The aim of this study is to investigate the effect of roughness, hydrophilicity and coating on osseointegration. Machined (smooth), sand-blasted (rough), hydrophilic and coated implants were testedin vivofor 2, 4 and 6 weeks. The hydrophilic surfaces were obtained by atmospheric oxygen plasma treatment of machined and sand-blasted implants. The coating is obtained by a spin-spray-process using sol-gel-technique. SEM and TEM investigations revealed that the coating consists of a nanoporous silica matrix with embedded synthetic, nanocrystalline hydroxyapatite. Histological polished sections were manufactured and the bone-to-implant-contact was calculated. The difference between smooth and rough implants was marginal and not significant. There were no statistical differences between hydrophilic and control implants, whereas the BIC of the hydrophilic surfaces was lower by trend. All coated implants offered an increased bone to implant-contact. However, the BIC was decreasing at 6 weeks due to the missing of mechanical stress and a faster bone metabolism in rabbits. The coating offers a new opportunity to enhance the osseointegration and therefore an earlier implant loading.