Дисертації з теми "Oropharyngeal Cancers"
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Oguejiofor, Kenneth Kenechukwu. "Prognostic markers in oropharyngeal cancers." Thesis, University of Manchester, 2016. https://www.research.manchester.ac.uk/portal/en/theses/prognostic-markers-in-oropharyngeal-cancers(fda96224-657d-4049-ae6c-50db33a5388a).html.
Повний текст джерелаSiembida, Jakub. "Implications of transoral robotic surgery on the field of otolaryngology: contemporary management of oropharyngeal cancers." Thesis, Boston University, 2012. https://hdl.handle.net/2144/12627.
Повний текст джерелаThe incidence and prevalence of cancers of the oropharynx has been on the rise over recent years, with approximately 13,000 new cases diagnosed each year in the United States. Increased incidence has been linked to increased alcohol consumption, tobacco use, and the human papilloma virus, and stresses the importance for the development of modern treatments. The majority of oral cancers are squamous cell carcinomas, originating in the mucosal tissue layer and metastasizing throughout the neck to surrounding lymph nodes and organs. Due to the difficulty in the detection of oropharyngeal cancers, they are often detected in late stage and must be removed surgically to maximize survival. Treatment of head and neck cancers falls under the responsibility of otolaryngologists, who utilize a wide variety of surgical and non-surgical procedures to minimize morbidity and maximize the patient's chances of survival while maintaining high quality of life. The classic approach to the treatment of head and neck cancers has been a combination of neck dissection, removal of lymph nodes, and radiation therapy to obliterate the disease in its entirety. Saving the life of the patient often results in many complications as a result of the invasive and aggressive treatments. In order to maximize the removal of the cancer, collateral damage to surrounding nerves, muscles, and other essential tissues often occurs with dissection of the neck. This radical approach often leaves little regard for the future quality of life of the patient, and alternatives are being sought to address these needs. Along with other surgical fields, otolaryngology is moving toward a minimally invasive approach in the treatment of oropharyngeal cancers. With the advent of modern technology and miniaturization of instruments, minimally invasive procedures such as endoscopic surgery, laser surgery, and concentrated radio- and chemotherapeutics have allowed otolaryngologists a greater range of possible treatments for their patients. In the recent evolution of surgical treatment, robots have been developed and adapted to assist surgeons in performing difficult procedures which are otherwise not possible. Utilizing robotic arms under the control of a trained surgeon, transoral robotic surgery allows for the removal of diseased tissue via the oral cavity. This recent procedural development allows surgeons to remove cancerous lesions from the head and neck without the need for a large external incisions. This approach minimizes tissue trauma, leaving unrelated organs and tissues of the neck intact. By reducing damage to surrounding structures, transoral robotic surgery improves the prognosis of, and speeds post-surgical recovery of the patient. Transoral robotic surgery is quickly gaining traction as an acceptable alternative to open surgeries in the management of head and neck cancers, allowing for preservation of structure and function. Although promising, many variables must be considered to determine whether it is in fact the most appropriate treatment. Factors such as quality of life, the ability to swallow and speak, recovery time, comorbidity, and survival must all be taken into consideration. While transoral robotic surgery presents many benefits to the surgical team and patient, there are inevitably some drawbacks and limitations to this new and promising technology. Only recently developed and approved for the minimally invasive treatment of head and neck cancers, it presents novel and exciting possibilities to the field of otolaryngology. By analyzing the literature on surgical treatment of oropharyngeal cancers over the past twenty years, I weigh the costs and benefits of transoral robotic surgery against traditional approaches to determine what role this new procedure plays in the contemporary management of oropharyngeal cancer.
Auluck, Ajit. "Epidemiological shifts and risk behaviours for oral and oropharyngeal cancers in multicultural population of British Columbia, Canada." Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/41390.
Повний текст джерелаDentistry, Faculty of
Graduate
Auluck, Ajit. "Epidemiological shifts and risk behaviors for oral and oropharyngeal cancers in multicultural population of British Columbia, Canada." Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/41390.
Повний текст джерелаChiriseri, Edina. "Human papilloma virus and oral cancers : sexual behaviour as a risk factor." Thesis, De Montfort University, 2017. http://hdl.handle.net/2086/16084.
Повний текст джерелаPirotte, Evelyne. "PARP inhibition in novel oropharyngeal cancer cell lines." Thesis, Cardiff University, 2017. http://orca.cf.ac.uk/109437/.
Повний текст джерелаLind, Mimmi. "Recurrence detection in oropharyngeal cancer –a retrospective cohortstudy." Thesis, Örebro universitet, Institutionen för medicinska vetenskaper, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-93177.
Повний текст джерелаWard, Matthew. "Identifying prognostic factors in oropharyngeal carcinoma." Thesis, University of Southampton, 2014. https://eprints.soton.ac.uk/376896/.
Повний текст джерелаDodd, R. H. "Examining the psychosocial impact of human papillomavirus oropharyngeal cancer." Thesis, University College London (University of London), 2016. http://discovery.ucl.ac.uk/1522414/.
Повний текст джерелаHouston, Karla Smalley. "The Cost of Treating Human Papillomavirus-Related Oropharyngeal Cancer." ScholarWorks, 2019. https://scholarworks.waldenu.edu/dissertations/6218.
Повний текст джерелаWaters, A. M. "A core outcome set for clinical trials in oropharyngeal cancer." Thesis, University of Liverpool, 2018. http://livrepository.liverpool.ac.uk/3022643/.
Повний текст джерелаWintour, Alisha M. "Evaluation of an information pamphlet for human papillomavirus positive oropharyngeal cancer patients." Thesis, Queensland University of Technology, 2022. https://eprints.qut.edu.au/228752/14/Alisha_Wintour_Thesis.pdf.
Повний текст джерелаHellman, Jennifer L. "The biobehavioral relationship between pain and stress in postoperative oropharyngeal cancer patients." Connect to resource, 2009. http://hdl.handle.net/1811/37134.
Повний текст джерелаAbram, Muhammed Hanif. "The incidence of oral and oropharyngeal cancer in South Africa for the five year period 1997-2001." Diss., University of Pretoria, 2013. http://hdl.handle.net/2263/24655.
Повний текст джерелаDissertation (MChD)--University of Pretoria, 2013.
Oral Pathology and Oral Biology
unrestricted
Holzhauser, Stefan. "Effect of ionising radiation on HPV-positive and HPV-negative oropharyngeal cancer cell lines." Thesis, Cardiff University, 2018. http://orca.cf.ac.uk/120510/.
Повний текст джерелаSchache, Andrew G. "The molecular and clinical implications of human papillomavirus-16 mediated oropharyngeal squamous cell carcinoma." Thesis, University of Liverpool, 2013. http://livrepository.liverpool.ac.uk/13433/.
Повний текст джерелаÄhrlund-Richter, Andreas. "Analysis of somatic mutations in papillomavirus positive tumours from younger and older oropharyngeal cancer patients." Thesis, Högskolan i Skövde, Institutionen för biovetenskap, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-12853.
Повний текст джерелаAlmarzouki, Hani. "Human Papillomavirus (HPV) infection and Erythropoietin Receptors (EPoR) expression as prognostic indicators in oropharyngeal cancer." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=119496.
Повний текст джерелаContexte: Le virus du papillome humain (VPH) est reconnu comme un facteur de risque indépendant pour les carcinomes épidermoïdes (CE) de la tête et du cou. De plus, la présence de l'ADN du VPH est associée à un meilleur pronostic. Des recherches récentes indiquent un plus grand rôle de l'érythropoïétine via une une activation de son récepteur (EpoR), qui est présent dans de nombreuses cellules non-hématopoïétiques néoplasiques. L'expression de EpoR dans un cancer peut représenter un processus de sélection qui permet aux cellules cancéreuses de survivre dans un environnement défavorable et peut aussi indiquer un comportement agressif des cellules cancéreuses. EpoR est variablement exprimé dans les cancers de la tête et du cou et pourrait prédire de façon indépendante une réponse plus faible aux traitements offerts aux patients. Objectifs: 1. Pour déterminer le statut VPH des cellules et la fréquence de l'expression du récepteur EpoR dans des biopsies obtenues de patients atteints du cancer épidermoïde oropharyngé. 2. Pour évaluer si la présence d'EpoR affecte la survie et si cet effet négatif est influencé par le statut VPH des cellules. Méthodes: Une étude rétrospective a été menée en examinant les dossiers de 97 patients atteints du cancer épidermoïde oropharyngé traités par radiothérapie comme intention curative au Centre universitaire de santé McGill, de 2000 à 2009. Les patients éligibles devaient avoir archivé des échantillons de tissus disponibles pour l'analyse VPH et EpoR. L'analyse de la présence du VPH a été effectuée en utilisant une réaction standard en chaîne par polymérase (PCR). La présence du récepteur EpoR a été déterminée par immunohistochimie en utilisant des marqueurs polyclonaux colorants anti-EpoR obtenus chez les lapins. Les sections de pathologie ont été analysées par 2 examinateurs indépendants par la microscopie optique conventionnelle. Un score de 0 à 300 a été déterminé pour chaque patient en multipliant le pourcentage de cellules néoplasiques contenant l'EpoR (0 à 100%) et l'intensité de la coloration de l'EpoR exprimée de 0 à 3. Résultats: L'âge médian était de 62 ans (extrêmes: 43-83). Le statut VPH a été positif chez 74% des patients. Ceci était significativement plus élevé chez les patients âgés ≤ 65 ans, p = 0,023. Les patients ayant des antécédents de tabagisme importants (> 10 paquet-années) et d'alcoolisme (> 4 verres / semaine) étaient significativement plus susceptibles d'être VPH négatif, p = 0,041 et 0,0001 respectivement. En analyse de régression de Cox, la présence de VPH était associé à une réduction de 29% du risque de décès (Hazard Ratio (HR) = 0,71, Intervalle de confiance (IC) 95%: 0,34 à 1,49), mais de façon non significative (p >0.05). Le statut EpoR était positif chez 27% des patients et a été associé à une augmentation non significative de 23% du risque de décès (RR = 1,23, IC 95%: 0,59 à 2,56). Les patients qui étaient positifs pour le VPH et négatifs pour l'EpoR avaient une réduction non significative de 33% du risque de décès (RR = 0,67, IC 95%: 0,29 à 1,56).Conclusion: Cette étude démontre une tendance qui indique que le VPH et le statut EpoR ont une corrélation avec la survie. Cette tendance persiste lorsque les patients sont divisés en sous-groupes (faible, intermédiaire et haut risque) en fonction de leur statut VPH / EpoR. Le groupe avec le plus faible risque de décès sont les patients avec le statut de VPH positif et EpoR négatif. Au meilleur de nos connaissances, cette étude est la première à examiner la relation entre l'EpoR et la survie chez les patients avec le cancer de la tête et du cou.
Ronchin, Philippe. "Les tumeurs oropharyngees : experience du centre oscar lambret sur 10 ans (1974-1983)." Lille 2, 1993. http://www.theses.fr/1993LIL2M141.
Повний текст джерелаLam, Wai-hung, and 林偉雄. "The current situation of human papillomavirus (HPV) associated oropharyngeal cancer : a multi-institutional cohort study in Hong Kong." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/206586.
Повний текст джерелаpublished_or_final_version
Surgery
Master
Master of Medical Sciences
Sahlin, Maria. "Sväljningssvårigheter hos patienter opererade för munhålecancer : en litteraturstudie." Thesis, Uppsala universitet, Institutionen för folkhälso- och vårdvetenskap, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-168213.
Повний текст джерелаThe aim of this literature review was to illuminate swallowing difficulties in oral and oropharyngeal cancer patients treated with surgery by studying which factors contribute to swallowing difficulties, how these patients experience their swallowing and how nursing staff can assist them. The study was based on 12 research articles. The literature search was performed in the PubMed and Cinahl databases. The result was subdevided on the basis of the methods used in the studies, videofluoroscopy and questionnaires. The presence and resection of tumours of the oropharynx, in particular of the base of the tongue, resulted in more severe swallowing dysfunction compared to tumours of the oral cavity in several of the videofluoroscopic studies. Self-assessment questionnaires showed that radiation therapy had a mayor negative effect on swallowing. In several studies large tumours/resections and an advanced stage had a negative impact on swallowing. In one study aspects of mouth function was ranked to be the most important of 12 important issues, swallowing coming in fourth place. One study that evaluated quality of life related to swallowing after surgery, found that the main factors effecting the quality of life were “eating duration”, “problems chewing” and “food sticking in your mouth”. In the search for studies answering the question of what actions nursing staff can apply in caring of oral and oropharyngeal cancer patients with swallowing difficulties after surgery no relevant study was found.
Brown, Elizabeth M. "Biologically guided adaptive radiotherapy treatment planning for virally-mediated head and neck cancer." Thesis, Queensland University of Technology, 2016. https://eprints.qut.edu.au/98899/1/Elizabeth_Brown_Thesis.pdf.
Повний текст джерелаAl-Sahaf, Sarmad. "Investigating the HPV-positive & HPV-negative oropharyngeal cancer tumour microenvironment in vivo and in vitro." Thesis, University of Sheffield, 2018. http://etheses.whiterose.ac.uk/22533/.
Повний текст джерелаShay, Keegan P. "Evaluating the use of neighborhoods for query dependent estimation of survival prognosis for oropharyngeal cancer patients." Thesis, University of Iowa, 2019. https://ir.uiowa.edu/etd/6854.
Повний текст джерелаJones, Gieira Shaquae. "RACIAL DISPARITIES IN HUMAN PAPILLOMAVIRUS PREVALENCE IN HEAD AND NECK CANCER PATIENTS: AN INTERNATIONAL POOLED AND META-ANALYSIS." Master's thesis, Temple University Libraries, 2013. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/216588.
Повний текст джерелаM.S.
Head and neck cancer (HNC) is one of the top ten cancers in the world, and is caused by tobacco use, alcohol consumption and Human Papillomavirus (HPV). HPV associated HNC patients have improved survival rates compared to non -HPV associated HNC patients. This improved survival is due to HPV- positive tumors favorable response to chemotherapy and radiation. The literature has shown that there is a racial disparity in survival rates between Caucasians and African Americans, with African Americans having poorer survival rates. The aim of this study is to determine if the racial disparity among HNC patients is due to a difference in HPV prevalence between races. HPV prevalence in HNC was assessed by a meta-analysis of published articles (30/247) that reported race specific HPV prevalence. We also conducted a pooled analysis in which authors that assessed HPV in HNC were invited to submit their datasets. Meta-pooled prevalence estimates revealed that 20% of African American HNC patients had HPV-positive tumors, compared to 44% in Caucasians. However for both African American HNC patients and Caucasian HNC patients there was low to moderate heterogeneity between the studies (Q-test p-value = p < 0.001, I2 = 18.87%, and p= 0.008. I2 =65.47% respectively). The prevalence of HPV in African Americans was 60% and in Caucasians it was 39%. African Americans had a risk of oropharyngeal cancer that was no different from Caucasians (OR: 1.38, 95% CI: 0.53-3.62) but had an increased risk of death from oropharyngeal cancer (HR: 2.39, 95% CI 1.03-5.55) compared to Caucasians. The results of the pooled analysis does not support the concept that African Americans HNC patients have a lower prevalence of HPV, but substantiates the notion that African Americans have worse survival than Caucasians. However, these are preliminary results as the pooled analysis is still being conducted, the inclusion of more datasets in the analysis could alter these preliminary findings.
Temple University--Theses
Bastos, Daniela Brito. "Plasma catecholamines levels in oral and oropharyngeal cancer patients and their associations with clinicopathological variables and anxiety symptoms /." Araçatuba, 2017. http://hdl.handle.net/11449/151501.
Повний текст джерелаCoorientador: Glauco Issamu Miyahara
Banca: Dulce Elena Casarini
Banca: Eder Ricardo Biasoli
Resumo: Objetivos: As catecolaminas podem regular diversos efeitos biológicos resultantes do estresse crônico. Estudos demonstram que as catecolaminas podem influenciar a progressão do câncer. No entanto, pouco se sabe sobre o perfil de secreção das catecolaminas em pacientes com câncer de cabeça e pescoço (CCP) e sua associação com as variáveis clinicopatológicas e psicológicas. O presente estudo investigou os níveis plasmáticos pré-tratamento das catecolaminas norepinefrina (NE) e epinefrina (E) em pacientes com câncer de boca e orofaringe e em pacientes com leucoplasia bucal, bem como sua associação com as variáveis clinicopatológicas, biocomportamentais e os sintomas de ansiedade. Pacientes e métodos: Um total de 71 pacientes com carcinoma espinocelular (CEC) de boca, 22 pacientes com CEC de orofaringe e 32 portadores de leucoplasia bucal foram submetidos à coleta de amostras de sangue. Os níveis plasmáticos das catecolaminas NE e E foram mensurados por meio de Cromatografia Líquida de Alta Eficiência com detecção eletroquímica (CLAE-ED) e os níveis psicológicos de ansiedade foram mensurados pelo Inventário de Ansiedade de Beck (IAB). As diferenças nos níveis hormonais entre os grupos foram avaliadas pelo teste ANOVA e análises univariadas e regressões múltiplas foram realizadas para avaliar as associações dos níveis hormonais com as variáveis clinicopatológicas, biocomportamentais e psicológicas. Resultados: As concentrações plasmáticas de NE e E foram significativamente maiores... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: Background: Catecholamines may regulate several biological effects resulting from chronic stress. Studies have shown that stress-related catecholamines may affect cancer progression. However, little is known about catecholamines secretion profile in head and neck cancer squamous cell carcinoma (HNSCC) patients and its association with clinicopathological and psychological variables. The present study investigated the pre-treatment plasma levels of catecholamines norepinephrine (NE) and epinephrine (E) in patients with oral and oropharyngeal SCC and patients with oral leukoplakia, as well as their associations with clinicopathological and biobehavior variables and anxiety symptoms. Patients and methods: A total of 71 patients with oral SCC, 22 patients with oropharyngeal SCC and 32 patients with oral leukoplakia were submitted to blood samples. Plasma levels of NE and E were measured by High Performance Liquid Chromatography with electrochemical detection (HPLC-ED) and psychological anxiety levels were measured by the Beck Anxiety Inventory (BAI). Differences in hormone levels among the groups were analyzed by ANOVA test. Univariate and multiple regression analyzes were performed to evaluate the associations of hormonal levels with clinicopathological, biobehavior and psychological variables. Results: Plasma NE and E concentrations were significantly higher in patients with oral and oropharyngeal cancer than oral leukoplakia patients (p<0.05). Oral SCC patients showed NE levels (462.03±47.53 pg/mL) about six times and nine times higher than patients with oropharyngeal SCC (74.46±12.52 pg/mL) and oral leukoplakia (51.69±6.28 pg/mL), respectively. Plasma NE and E levels were positively correlated in patients with oral SCC (p=0.0011), but not in the oropharyngeal SCC and oral leukoplakia groups. Multiple...
Mestre
Zdilar, Luka. "Evaluating the effect of right-censored endpoint transformation for dimensionality reduction of radiomic features of oropharyngeal cancer patients." Thesis, University of Iowa, 2018. https://ir.uiowa.edu/etd/6346.
Повний текст джерелаSantos, Ingrid da Silva [UNESP]. "Absence of human papillomavirus in fresh tissue of oral cavity and oropharynx cancer in patients from the northwest region of São Paulo, Brazil." Universidade Estadual Paulista (UNESP), 2017. http://hdl.handle.net/11449/150980.
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Fundação de Amparo à Pesquisa do Estado do Amazonas (FAPEAM)
Evidências sugerem que o papilomavírus humano (HPV) está associado com um subgrupo de carcinomas de células escamosas da cabeça e pescoço (HNSCC). No entanto, a prevalência do HPV varia substancialmente dependendo do local anatômico e da região geográfica estudada. Aqui, nosso objetivo foi investigar a prevalência do HPV em amostras de tecido fresco de pacientes brasileiros com carcinoma de células escamosas (CEC) de boca e orofaringe combinando dois métodos confiáveis para a detecção do HPV. Foram recrutadas trinta e seis amostras de tecido fresco provenientes de CEC de boca (n= 27) e orofaringe (n= 9) para análises. As características sociodemográficas, estilo de vida e clinicopatológicas foram coletadas através dos prontuários. O DNA do HPV foi detectado por dois métodos: reação em cadeia da polimerase (PCR) em tempo real através de ensaio qualitativo de presença ou ausência do HPV-16, e testado para 37 genótipos usando Linear Array. A amplificação do gene β -globina funcionou como controle interno positivo para a análise do DNA em todas as amostras. O DNA do HPV não foi detectado em nenhum dos casos de amostras de tecido de pacientes com CEC em ambos os métodos utilizados. A ausência do HPV observada em nosso estudo pode sugerir que este não é um fator de risco prevalente nos CECs de boca e orofaringe nesta região geográfica. Os fatores de risco clássicos para o desenvolvimento desses tumores parecem ser ainda a principal causa nessa população brasileira. Investigações detalhadas do estilo de vida com maior amostragem precisam ser melhor exploradas para compreensão da baixa prevalência encontrada.
Evidence suggests that human papillomavirus (HPV) is associated with a subgroup of squamous cell carcinomas of the head and neck (HNSCC). However, the prevalence of HPV varies substantially depending on the anatomical site and geographic region studied. Here, our goal was to investigate the prevalence of HPV in fresh tissue samples from Brazilian patients with squamous cell carcinoma (SCC) of the oral cavity and oropharynx by combining two reliable methods for the detection of the HPV DNA. We recruited thirty-six fresh tissue samples from SCC of the oral cavity (n= 27) and oropharynx (n= 9) for analysis. The sociodemographic, lifestyle and clinicopathological characteristics were obtained from individual medical records. HPV DNA was detected by two methods: real-time polymerase chain reaction (PCR) through the qualitative assay of presence or absence for HPV-16, and tested for 37 genotypes by the Roche Linear Array. Amplification of the β-globin gene functioned as a positive internal control for DNA analysis in all samples. HPV DNA was detected in none of the tissue samples from patients with SCC in both methods. The absence of HPV observed in our study may suggest that this is not a prevalent risk factor in SCC of the oral cavity and oropharynx in this geographical region. The classic risk factors for the development of these tumors seem to be still the main cause in this Brazilian population. Detailed investigations of lifestyle with larger sample needs to be better explored to understand the low prevalence found.
FAPEAM: 120/2015
Shepherd, Karen Louise. "An investigation of the experience of patients with oral and oropharyngeal cancer : from diagnosis to three months post treatment." Thesis, University of Nottingham, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.272360.
Повний текст джерелаSmith, Eric A. B. S. "DEK is a Homologous Recombination DNA Repair Protein and Prognostic Marker for a Subset of Oropharyngeal Carcinomas." University of Cincinnati / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ucin150480040523791.
Повний текст джерелаQian, Xu [Verfasser]. "ALDH1-positive cancer stem-like cells enrich in nodal metastases of oropharyngeal squamous cell carcinoma independently of HPV-status / Xu Qian." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2013. http://d-nb.info/1043197427/34.
Повний текст джерелаLim, Yen Kai. "Oral microbiome: A novel biomarker for oral cavity and oropharyngeal cancer detection and a potential surveillance tool for post-treatment monitoring." Thesis, Queensland University of Technology, 2019. https://eprints.qut.edu.au/130735/1/Yen%20Kai_Lim_Thesis.pdf.
Повний текст джерелаDwivedi, Raghav Chandra. "A comprehensive assessment of funtional outcomes and their impact on the quality of life in surgically treated oral and oropharyngeal cancer patients." Thesis, Institute of Cancer Research (University Of London), 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.536234.
Повний текст джерелаDugoni, Meredith L. "Role of the Pediatric Dental Provider in Human Papillomavirus (HPV) Education." VCU Scholars Compass, 2017. http://scholarscompass.vcu.edu/etd/4733.
Повний текст джерелаEvans, David Robert. "Survivorship experiences of working-age adults previously treated for oropharyngeal cancer : moving towards a post-treatment self, its hidden impact and an absence of recognition : an interpretative phenomenological analysis." Thesis, Cardiff University, 2018. http://orca.cf.ac.uk/112772/.
Повний текст джерелаAzevedo, Paulo Roberto Medeiros de. "C?ncer de boca e orofaringe: tend?ncias e an?lise de sobrevida em Natal (RN)." Universidade Federal do Rio Grande do Norte, 2010. http://repositorio.ufrn.br:8080/jspui/handle/123456789/13182.
Повний текст джерелаIntroduction: Mouth cancer is classified as having one of the ten highest cancer incidences in the world. In Brazil, the incidence and mortality rates of oral cancer are among the highest in the world. Intraoral cancer (tongue, gum, floor of the mouth, and other non-specified parts of the mouth), the accumulated survival rate after five years is less than 50%. Objectives: Estimate the accumulated survival probability after five years and adjust the Cox regression model for mouth and oropharyngeal cancers, according to age range, sex, morphology, and location, for the city of Natal. Describe the mortality and incidence coefficients of oral and oropharyngeal cancer and their tendencies in the city of Natal, between 1980 and 2001 and between 1997 and 2001, respectively. Methods: Survival data of patients registered between 1997 and 2001 was obtained from the Population-based Cancer Record of Natal. Differences between the survival curves were tested using the log-rank test. The Cox proportional risk model was used to estimate risk ratios. The simple linear regression model was used for tendency analyses of the mortality and incidence coefficients. Results: The probability after five years was 22.9%. The patients with undifferentiated malignant neoplasia were 4.7 times more at risk of dying than those with epidermoid carcinoma, whereas the patients with oropharyngeal cancer had 2.0 times more at risk of dying than those with mouth cancer. The mouth cancer mortality and incidence coefficients for Natal were 4.3 and 2.9 per 100 000 inhabitants, respectively. The oropharyngeal cancer mortality and incidence coefficients were, respectively, 1.1 and 0.7 per 100 000 87 inhabitants. Conclusions: A low survival rate after five years was identified. Patients with oropharyngeal cancer had a greater risk of dying, independent of the factors considered in this study. Also independent of other factors, undifferentiated malignant neoplasia posed a greater risk of death. The magnitudes of the incidence coefficients found are not considered elevated, whereas the magnitudes of the mortality coefficients are high
Introdu??o: O c?ncer de boca ? classificado como uma das dez maiores incid?ncias de c?ncer no mundo. No Brasil, as taxas de incid?ncia e de mortalidade por esse c?ncer encontram-se entre as mais elevadas do mundo. Para o c?ncer intraoral (l?ngua, gengiva, base da boca e outras e n?o especificadas partes da boca), a taxa acumulada de sobrevida ap?s 5 anos ? menor que 50%. Objetivo: Estimar a probabilidade acumulada de sobrevida ap?s 5 anos, ajustar o modelo de regress?o de Cox para os c?nceres de boca e de orofaringe, segundo faixa et?ria, sexo, morfologia e localiza??o, para a cidade de Natal, Brasil. Descrever os coeficientes de mortalidade e de incid?ncia dos c?nceres de boca e de orofaringe e as tend?ncias desses coeficientes para a cidade de Natal, nos per?odos de 1980 a 2001 e de 1997 a 2001, respectivamente. Metodologia: Foi obtida a sobrevida de pacientes registrados entre 1997 e 2001 no Registro de C?ncer de Base populacional de Natal. Foram testadas as diferen?as entre as curvas de sobrevida atrav?s do teste log-rank. O modelo de riscos proporcionais de Cox foi utilizado para estimativas das raz?es de riscos. O modelo de regress?o linear simples foi utilizado para as an?lises de tend?ncia dos coeficientes de incid?ncia e de mortalidade. Resultados: A probabilidade acumulada ap?s 5 anos para todos os casos foi de 22,9%. Os pacientes com neoplasia maligna indiferenciada t?m 4,7 vezes mais risco de morrer do que aqueles com carcinoma epiderm?ide, enquanto que os pacientes com c?ncer de orofaringe t?m 2,0 vezes mais risco de morrer do que aqueles com c?ncer de boca. Os coeficientes padronizados de mortalidade e de incid?ncia do c?ncer de boca em Natal foram, respectivamente, 2,9 e 4,3 por 100 mil habitantes. Para o c?ncer de orofaringe 10 os coeficientes obtidos de mortalidade e de incid?ncia foram, respectivamente, 1,1 e 0,7 por 100 mil habitantes. Conclus?o: Identifica-se uma baixa taxa de sobrevida ap?s 5 anos. Pacientes com c?ncer de boca apresentam menos risco de morte, independentemente dos fatores considerados neste estudo. Tamb?m de forma independente dos demais fatores, a neoplasia maligna indiferenciada apresenta um maior risco de morte. As magnitudes dos coeficientes de incid?ncia encontradas n?o s?o consideradas elevadas, enquanto que de forma contr?ria est?o as magnitudes dos coeficientes de mortalidade
Hanns, Elodie. "Analyse et caractérisation moléculaire de l'hypoxie intratumorale de carcinomes épidermoïdes de l'oropharynx." Thesis, Strasbourg, 2014. http://www.theses.fr/2014STRAJ063/document.
Повний текст джерелаHead and neck squamous cell carcinoma (HNSCC) represents the sixth most common malignancy worldwide. The major risk factors for HNSCC identified are tobacco use and alcohol consumption (80% of all HNSCC), which seem to have a synergistic effect. A subgroup of HNSCCs (20% of cases), particularly those of the oropharynx, is caused by infection with high-risk types of human papillomavirus (HPV). Human papillomavirus HPV-related oropharyngeal squamous cell carcinoma defines a distinct clinical subgroup of head and neck cancer patients with improved prognosis. Currently, one of the several hypothesis studied to account for their improved survival outcomes could be a distinct hypoxia status compared to their HPV-negative counterpart. Indeed, tumour hypoxia is common in solid tumours including head and neck tumours, and hypoxia is a well-known poor prognosis factor. In first part of this thesis, we have performed a molecular characterisation of tumor hypoxia on cohort of oropharyngeal tumours according to HPV status of the patients. The results support the hypothesis that HPV-related tumours display a lesser hypoxia status compared to HPV-negative oropharyngeal tumours. These HPV-related tumours also characterize by an abundant tumour vascularisation, which could be responsible for a lesser hypoxia status. In a second part, we have studied the ability of the adaptation to hypoxia of the HPV-positive SCC90 cell line and HPV-negative SQ20B cell line. Furthermore, HPV-positive and HPV-negative HNSCC xenograft models have been established and have been analysed about tumor hypoxia. Similar to HPV-related HNSCC, tumours-derived HPV positive cell lines display a reduced hypoxic status compared to tumours-derived HPV negative cell lines. The two cell lines adapt also differently to in vitro hypoxia. In the HPV-positive cell line, the hypoxia response pathways could be more dynamics. Indeed, SCC90 cell lines attempt to adapt and to reply to hypoxic environment inducing highly expression of all of the hypoxia related genes compared to SQ20B cell lines
Nishimura, Luciana Sigueta. "Polimorfismo PRO198LEU no gene para a enzima antioxidante dependente de selênio glutationa peroxidase 1 e risco de câncer epidermóide da cavidade oral e orofaringe." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/89/89131/tde-31012011-102550/.
Повний текст джерелаSelenium is an essential micronutrient that presents antioxidant activity through selenoproteins such as glutathione peroxidase 1 (GPX1). PRO198LEU polymorphism in this gene has been associated with increased risk for some cancer types such as breast and lung cancers. Currently head and neck cancer is a major public health problem in the world and in Brazil. The aim of this study was to evaluate a possible association between GPX1 PRO198LEU polymorphism and risk of oral cavity and oropharyngeal squamous cell cancer. GPX1 PRO198LEU polymorphism genotype was determined by PCR-RFLP method (Polymerase chain reaction-Restriction fragment length polymorphism) and DNA sequencing in 175 patients with oral cavity and oropharyngeal squamous cell cancer (case group) from the Head and Neck Cancer Clinical Genome Project, and in 203 cancer-free individuals, hospitalized in the wards of Heliopolis Hospital (control group). The frequency of reference and polymorphic allele was 0.72 and 0.28, respectively, in both groups. The genotype distribution was in Hardy-Weinberg equilibrium in case and control groups. There was no statistically significant difference (p> 0.05) on the distribution of genotype for the GPX1 PRO198LEU polymorphism between cases (50% PRO/PRO, 43% PRO/LEU and 7% LEU/ LEU) and controls (51% PRO/PRO, 43% PRO/LEU and 6% LEU/LEU) and there was no association between this polymorphism and risk for oral cavity and oropharyngeal squamous cell cancer (odds ratio = 1.02, 95% CI = 0.68 to 1,53; p = 0.51; polymorphic homozygotes and heterozygotes combined compared with reference homozygotes). Furthermore, the use of tobacco or alcohol intake did not change the lack of association between the GPX1 PRO198LEU polymorphism and cancer risk (use of tobacco greater than 20 pack years: odds ratio = 0.94, 95% CI = 0.53 to 1,70, p = 0.49; alcohol intake greater than 80g etanol/day: Odds ratio = 0.80, CI = 0.46 to 1.39, p = 0.26). We conclude that this polymorphism does not increase the risk of oral cavity and oropharyngeal squamous cell cancer.
Santos, Edilmar de Moura. "Valor progn?stico de c?lulas TCD8+ E natural killer em carcinoma epiderm?ide oral e orofaringeano tratado com radioterapia e quimioterapia." Universidade Federal do Rio Grande do Norte, 2012. http://repositorio.ufrn.br:8080/jspui/handle/123456789/17124.
Повний текст джерелаCoordena??o de Aperfei?oamento de Pessoal de N?vel Superior
The most common malignant neoplasm of the oral cavity and oropharynx are squamous cell carcinoma. Injuries to the same stage and subjected to the same treatment protocol have sometimes different evolutionary courses. The scope of this study was to investigate, through a retrospective cohort, associations between the number of CD8 + T cells and natural killer, identified immunohistochemically in the inflammatory infiltrate in a series of cases of oral squamous cell carcinoma and orofaringeano, and the level of tumor response to radiotherapy and chemotherapy, overall survival and relapse-free survival of patients. We identified 54 patients with unresectable disease were treated exclusively with radiotherapy and chemotherapy. The median follow-up was 22 months. The sample was characterized by the predominance of male subjects, median age 60 years, all were smokers. The most frequent site was the tongue and 81.5% were in stage IV. Patients with disease in the oral cavity had a worse response to treatment (p = 0.006), worse relapse-free survival (p = 0.007), worse overall survival (p = 0.007). The advanced T stage was shown a negative prognostic factor (p= 0.006) for the clinical treatment response made. Immunohistochemistry was performed to select CD8 + cells (anti-CD8) and NK cells (anti-CD57). Lymphocytes positive and negative markings were counted using the program ImageJ ?. Two groups were created for each marking evaluated: Group I patients with more than 50% cells positive, Group II: less than 50% of labeled cells. For CD8 + cells detected in 38 (70.3%) of Group I were CD8 + and 16 (29.7%) Group II CD8 +. For NK cells, 26 (48.15%) Group I NK and 28 (51.85%) Group II NK. Regarding the clinical response to treatment, we observed that 39% of patients achieved a complete response and 25.9% remained without recurrence at the end of follow-up. These results were better in Group I CD8 + (p = 0.2). Identified that 72.2% of patients progressed to death, this finding had no association with the immunohistochemical data. There was no statistically significant differences between the number of CD8 + and NK cells and the ability of tumor response to radiotherapy and chemotherapy, or with overall survival and relapse-free survival of patients. However, especially in relation to a learned response, we found that this group of patients with advanced disease have a low count of CD8 + T cells active. Believing in the role that the immune response plays in the local fight against neoplastic cells, however, our results do not support the use of quantitative analysis of CD8 + T cells and NK cells as a prognostic factors for oral squamous cell carcinoma and oropharynx
A neoplasia maligna mais frequente da cavidade oral e da orofaringe ? o carcinoma epiderm?ide. Les?es com o mesmo estadiamento e submetidas ao mesmo protocolo terap?utico apresentam, por vezes, cursos evolutivos diferentes. O escopo do presente trabalho foi investigar, atrav?s de um coorte retrospectivo, associa??es entre a quantidade de c?lulas TCD8+ e natural killer, identificadas imuno-histoquimicamente no infiltrado inflamat?rio de uma s?rie de casos de carcinoma epiderm?ide oral e orofaringeano, e o n?vel de resposta tumoral ao tratamento radioter?pico e quimioter?pico, a sobrevida global e sobrevida livre de recidiva dos pacientes. Foram identificados 54 pacientes com doen?a irressec?vel, tratados exclusivamente com radioterapia e quimioterapia. A mediana de seguimento foi de 22 meses. A amostra se caracterizou pelo predom?nio de indiv?duos masculinos, com idade mediana de 60 anos; todos eram tabagistas. O s?tio mais frequente foi a l?ngua oral e 81,5% encontravam-se no est?dio IV. Os pacientes com doen?a na cavidade oral tiveram uma pior resposta ao tratamento (p=0,006), pior sobrevida livre de recidiva (p=0,007), pior sobrevida global (p=0,007). O est?dio T avan?ado se demonstrou um fator progn?stico negativo (p=0,006) para a resposta ao tratamento cl?nico efetuado. Foi realizada imuno-histoqu?mica para marcar c?lulas CD8+ (anti-CD8) e c?lulas NK (anti-CD57). Os linf?citos positivos e negativos para as marca??es foram contados atrav?s do programa ImageJ?. Dois grupos foram criados para cada marca??o avaliada: Grupo I: pacientes com mais de 50% das c?lulas positivas; Grupo II: menos de 50% das c?lulas marcadas. Para as c?lulas CD8+ detectamos que 38 (70,3%) eram do Grupo I CD8+ e 16 (29,7%) do Grupo II CD8+. Para as c?lulas NK, 26 (48,15%) Grupo I NK e 28 (51,85%) Grupo II NK. Em rela??o ? resposta cl?nica ao tratamento, observamos que 39% dos pacientes obtiveram resposta completa e 25,9% permaneceram sem recidiva ao final do seguimento. Esses resultados foram melhores no Grupo I CD8+ (p=0,2). Identificamos que 72,2% dos pacientes evolu?ram para o ?bito, esse achado n?o teve associa??o com os dados imuno-histoqu?micos. N?o se observou diferen?as estatisticamente significantes entre a quantidade de c?lulas CD8+ e NK e a capacidade de resposta tumoral ao tratamento radioter?pico e quimioter?pico, nem com a sobrevida global e sobrevida livre de recidiva dos pacientes. Contudo, principalmente em rela??o a resposta adquirida, detectamos que este grupo de pacientes com doen?a avan?ada tem uma baixa contagem de c?lulas TCD8+ ativas. Acreditando no papel fundamental que a resposta imune exerce no combate local ?s c?lulas neopl?sicas; no entanto, nossos resultados n?o suportam a utiliza??o da an?lise quantitativa das c?lulas TCD8+ e NK como um dos fatores progn?sticos para o carcinoma epiderm?ide oral e de orofaringe
Ramdas, Yastira. "Pattern of practice of radical radiation therapy for oropharyngeal cancers: a retrospective review from January 2009 to December 2012." Thesis, 2015. http://hdl.handle.net/10539/18478.
Повний текст джерелаRadiation therapy is a highly effective method of treating oropharyngeal carcinoma, either as a single modality treatment with concurrent chemotherapy or as an adjuvant treatment after surgical resection. There exists an association with human papillomavirus (HPV) and oropharyngeal cancer, dividing oropharyngeal carcinoma into HPV positive oropharyngeal carcinoma and HPV negative oropharyngeal carcinoma. Overall survival has been analysed in these two groups and have been shown to be 80-95% for HPV positive oropharyngeal carcinomas and 57-62% in HPV negative subgroup at 3 years respectively. This retrospective review was intended to analyse patient response to treatment, overall survival, local disease free survival and the difference between HPV positive oropharyngeal carcinoma and HPV negative oropharyngeal carcinoma at Charlotte Maxeke Johannesburg Academic Hospital: Department of Radiation Oncology. Patients and methods A retrospective descriptive study was conducted on patients having received radical radiation therapy, with or without chemotherapy, from January 2009 to December 2012 with a histologically confirmed diagnosis of squamous cell carcinoma involving oropharyngeal sites only. The information obtained from records of forty-eight patients was captured on the prescribed data sheets designed for this study. Results Forty-eight eligible patients were accrued within this retrospective study. The median age of the patient group was 56 years (range 32-78) and comprised of 10 females and 38 males. The performance status was mainly Eastern Cooperative Oncology Group (ECOG) 1 (83%). The radiation therapy dose was within the range 60-70Gy, with majority patients completing 70 Gy (65%). Concurrent chemoradiation was given in 59% of patient group (28 patients). The most common site being the base of tongue (60%), followed by tonsil (36%), soft palate (2%) and posterior pharyngeal wall (2%). Eighty five percent of patients were stage IV oropharyngeal carcinoma. Only 6% of patients were tested for HPV-DNA PCR, and all were HPV positive. A total of 79% patients had a positive smoking history and 50% consumed alcohol regularly. Fifty six percent of patients tested negative for HIV, 14.6% tested positive for HIV and 29.3% had unknown HIV status. At the time of the analyses (March 2014) only 7 (15%) of patients were alive. The 2 year overall survival was 13%, the local disease free survival at 2 years was 59%. None of the prognostic factors were predictive of overall survival using univariate and multivariate analysis. Conclusion Majority of patients present in stage IV lesions with commonest sites of involvement being Base of Tongue. The local disease free survival of 2 years was 59% and the overall survival of 15%. There was no impact of prognostic factors studied on overall survival.
Knapik, Monika. "Modèle cellulaire de carcinogenèse pour les cancers de l’oropharynx induits par le VPH." Thèse, 2014. http://hdl.handle.net/1866/13405.
Повний текст джерелаBackground: Human papillomavirus (HPV) is present in almost 50% of all oropharyngeal cancers. The oncogenic potential of HPV is encoded by the E6 and E7 oncoproteins, which act by modulating different genes, including tumour suppressor genes p53 and pRb. The process of inactivation of p53 and pRb is largely responsible for the genomic instability that contributes to malignant transformation of cells. HPV-positive cancer cells show an alteration in their DNA Damage Response (DDR) signalling pathway that allows them to inhibit key tumour suppressor genes and to ignore DNA damage signals. Hypothesis and objectives: We believe that these DDR defects can be exploited to preferentially sensitize cancerous cells to radiotherapy by using a defined cell culture model. We propose to characterize a defined cell culture model for HPV induced oropharyngeal cancer. Derive isogenic cell culture lines from primary skin keratinocytes and oropharyngeal epithelial cells. and to validate the carcinogenesis of our model in vitro and in vivo. Methods: We propose to use primary skin keratinocytes and oropharyngeal epithelial cells which will be sequentially modified by transduction using a Gateway Lentiviral System to present the mutations associated with HPV induced oropharyngeal cancer. The cells will be modified with lentivirus encoding the human telomerase (hTERT), E6, E7 and Ras oncogenes. To validate the in vitro carcinogenesis of our model, we will assess anchorage independent growth and invasiveness by means of soft agar medium and matrigel studies. To assess in vivo tumorigenicity, the transformed cell populations will be introduced into immunodeficient mice. Results: We constructed recombinant lentivector plasmids using traditional cloning and Gateway recombination methods. Using the constructed lentivectors, we generated lentiviruses encoding the catalytic subunit for human telomerase (hTERT), the E6 and E7 viral oncogenes and Ras oncogene. Primary keratinocytes and oropharyngeal epithelial cells were infected successively by transduction with the above-mentioned lentiviruses and then underwent selection. We validated the expression of our transgenes by methods of immunofluorescence, Western blot and real-time quantitative polymerase chain reaction (qRT-PCR). We have successfully established and kept in culture three lines of epithelial oropharyngeal cells (HNOE42, HNOE45, HNOE46) from tissue samples collected during tonsillectomy. Cells transduced with lentivirus expressing CMV/TO, a strong promoter for the RasV12 oncogene, showed morphological changes compatible with premature Ras oncogene induced senescence. Cell line HEKn hTERT-E6-E7 PGK RasV12 managed to escape Ras oncogene induced senescence by expressing lower amount of mutated RasV12. The HEKn hTERT-E6-E7-PGK RasV12 cell line presented a malignant phenotype in culture and on matrigel invasion assay. However, soft agar assay for anchorage independent cell growth and xenograft assay in immunodeficient mice were both negative for tumorigenicity. Conclusion: Our results demonstrate that in the presence of E6 and E7, a third tumor suppressor mechanism mediates Ras oncogene induced senescence. Furthermore, we have found that the presence of E6 alone is not sufficient to immortalize primary human keratinocytes (HEKn). We have not managed to create an in vitro carcinogenesis cell culture model for HPV induced oropharyngeal cancer.
Pei-shan, Ho, and 何佩珊. "The epidemiology of oropharyngeal cancer." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/x4r333.
Повний текст джерела高雄醫學大學
牙醫學研究所
90
The Incidence of Oropharyngeal Cancer in Taiwan Abstract Backgroud: Orapharyngeal cancer is the one of the most common cancers in the world. The purpose of this study was to examine the time trends of oropharyngeal cancer from 1979 to 1996 in Taiwan. Method: Traditional cohort analysis was employed to show the birth-cohort effect of oropharyngeal cancer incidence. Age-period-cohort model analysis was used to examine the age, period, and cohort effect betw Ethnic Differences in Oropharyngeal Cancer of Taiwan Abstract Background: Oropharyngeal cancer incidence of Taiwan is remarkable high in the world. But ethnic difference may exist in pattern of oropharyngeal cancer of Tawain. The purpose of this study was to examine the oropharyngeal cancer pattern among different ethnic groups of Taiwan. Methods: The population divided into three ethnic groups, which were Fukkien, Hakka, and aboriginal communities. Standardized mortality rate ratios (SMRs), standardized incidence rate ratios (SIRs) and their ratios were estimated among these ethnic groups from 1971-1997. Results: We found that the oropharyngeal cancer in high betel quid chewing aboriginal group was significantly higher than reference group (male: SMR=1.21, SIR=1.12; female SMR=4.3, SIR=2.62). The aboriginal groups also had an excess oropharyngeal cancer (based on SMR/SIR ratios), especially in aboriginal females. The incidence and mortality rate of oropharyngeal cancer in Hakka was significantly lower than in reference group. Conclusion: The pattern of oropharyngeal cancer in Taiwan showed ethnic differences. Betel quid chewing might be the major etiology related with the higher oropharyngeal cancer of aboriginal groups, and the excess fatality in aboriginal groups might due to lower socioeconomic status and worse medical access, especially in females. een intra-oral and pharyngeal cancer. Result: A significant rising trend in oropharyngeal cancer has been seen in males. From the proportion of subsites, the major increasing subsites were on the tongue and mouth in males, and on the tongue in females. In males, we also found an increasing trend in successive cohorts born after 1929. The incidence of intra-oral cancer of male had a greater increase than pharyngeal cancer in the younger age group, recent time periods, and the late birth cohorts. Conclusion: The increasing trend of oropharyngeal cancer incidence of Taiwan is likely to be heavily influenced by the rising consumption of alcohol and betel quid, and the effect of these etiologies was more significant on intra-oral cancer in recent periods, later cohorts, and the younger age group.
Yang, Hsiu-Fei, and 楊琇妃. "Epidemiological study of oropharyngeal cancer- Distinct features in Changhua." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/63458103288788221560.
Повний текст джерела國立彰化師範大學
數學系所
94
Abstract Purpose: Oropharyngeal cancer is one of the fastest increasing malignancies in Taiwan. Among the counties on the island, Changhua has been ranked in the top three in the list of oropharyngeal cancer incidence. We start the study to better characterize the epidemiology of oropharyngeal cancer in the Changhua County. The study goal was to (1) Compare the incidence rate of Changhua to rest areas in Taiwan and the correlation of risk factors. (2) Compare the survival rate of Changhua to rest areas in Taiwan by gender. Methods: We use the complete registered records of oral cancer from the data bank of Department of Health (DOH). The records of 30041 oropharyngeal cancer patients(ICD9 140-149, except 142、147) from 1986 to 2001. We study the trend of incidence rate, age of distribution, anatomic sites, survival rate of oropharyngeal cancer in Changhua and compare different with rest areas in Taiwan. In addition, we correlate the incidence rate with known risk factors (betel quid chewing, smoking, and alcohol drinking) by regression method. We selected some environmental risk factor such as water pollution, metal pollution in farmland and industrial region, to further study the relationship in Changhua County. Results: Incidence rate of oropharyngeal cancer in Changhua is among the highest in the world, and was the highest among the 23 counties in Taiwan in 2001 (45.07 per 105 per year). We can see a steady increase in the male oropharyngeal cancer, the male to female incidence ratio of oropharyngeal cancer increased to 19:1 in 2001. The most common site was buccal, while it was tongue in the rest counties. Finally, Changhua is the only outlier in our regression model, indicating an unusual relation between cancer incidence and prevalence of betel quid chewing in Changhua. To investigate the influence of environmental factors, the results show that the contents of arsenic in groundwater and numbers of factory are on the high side in high incidence area, the correlation between high incidence rate in tongue and the contents of arsenic and nickel in farmland, high incidence rate in tongue and numbers of factory in town are positive. The correlation between high incidence rate in buccal mucosa and numbers of factory in town is also positive. Using Kaplan-Meier survival analysis, the male of oropharyngeal cancer five-year survival rate was 51.11% in Changhua, similar to looks of rest areas in Taiwan (52.23% ). In contrast, the female five-year survival rate was 61.03% in Changhua, low nearly 8% with rest areas in Taiwan(69.10%), the adjusted hazard ratio of Changhua versus rest areas in Taiwan was 1.18 (95%CI, 0.68-2.05) for oropharyngeal cancer death. Conclusions: Over the years of the study, the incidence of male oropharyngeal cancer increased significantly from 6.31 to 27.04 per 105 men per year. Age of diagnosis of male oropharyngeal cancer is shifting to a younger age in recent years. The mean age of 54 in 1986-1989 is decreasing to 51 in 1998-2001 The high and fast increasing incidence of oral cancer in Changhua signifies the importance of this cancer locally, no less than that of liver cancer and lung cancer. An unusual relation with known risk factors (betel quid chewing, smoking, and alcohol drinking) indicates other unknown factor/factors may be involved in the etiology of oral cancer in Changhua. We tried to separate Changhua county by incidence rate in each town and village and probable environment factors. Although we still can’t find the strong evidence out by searched environment data presently, but we also find out the specialty of oropharyngeal cancer in Changhua by multi discussion. Further study is needed, and is ongoing by searching new data to clarify the specialty of oropharyngeal cancer in Changhua.
Dahlstrom, Kristina Riis Sturgis Erich M. "The association of sexual behavior with oropharyngeal cancer and correlations with HPV-16 serologic status." 2007. http://proquest.umi.com/pqdweb?did=1292467891&sid=1&Fmt=2&clientId=68716&RQT=309&VName=PQD.
Повний текст джерелаWu, Pei-Shan, and 吳佩珊. "A mathematical model of oropharyngeal airway space volume assessment by computed tomography in oral cancer patients." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/63658994258831034873.
Повний текст джерела國立陽明大學
臨床牙醫學研究所
96
The incidence and increase rate of oral cancer have kept increasing in Taiwan recently. After treatment of oral cancer, including surgery, radiotherapy and/or chemotherapy, the incidence causing airway change varied from 8%-92%, indicating that patients who have been successfully treated for oral cancer often have a partially airway changes after surgery. The methods analyzing airway space change in the literature include magnetic resonance imaging (MRI), lateral cephalometric film, and 3-dimensional computed tomography (3-D CT). The 3-D CT has been reported as a reliable instrument evaluating the volumetric change of airway space. The objective of the present investigation is to establish norm data on this line of study by a mathematical model of oropharyngeal airway space volume assessment based on a 3-D CT reconstruction. Results showed that the oropharyngeal airway space of patients with oral cancer after treatment was significantly larger than that before treatment. The factors explaining the current results are also discussed.
Vashist, Aastha. "Genetic Differentiation of oral and oropharyngeal carcinoma based on Human Papillomavirus Status and Race." 2016. http://scholarworks.gsu.edu/iph_theses/500.
Повний текст джерелаValente, Carlos Emanuel Baptista. "Modelo de infeção do HPV na orofaringe: revisão narrativa." Master's thesis, 2021. http://hdl.handle.net/10284/10821.
Повний текст джерелаThe Human Papilloma Virus (HPV), a virus commonly associated to cervical carcinoma, also infects the basal cells of the stratified epithelium of the oropharynx and is etiologically associated to Squamous Cell Cancer of the Head and Neck. Oral infection by HPV, namely by HPV-16 and 18, presents classic risk factors such as tobacco and alcohol and its incidence vary according to the sexual behaviour of the infected individuals. HPV infection in the oropharynx has a very specific course not only because of the anatomical site affected, but also because a high number of individuals with early-stage HPV+ tumours are asymptomatic. Oropharyngeal Squamous Cell Carcinoma when associated with HPV infection has a better prognosis although the model of infection is not well known. It is very important not only to study it but also to analyze the prevention that may be carried out by the dentist.
Elfring, Tracy Tamiko. "Surgical reconstruction of the lingual and hypoglossal nerves in oropharyngeal cancer: anterior oral cavity sensorimotor and quality of life outcomes." Master's thesis, 2010. http://hdl.handle.net/10048/1163.
Повний текст джерелаSpeech-Language Pathology
Morey, Tristan. "Accuracy of Imaging Modalities for Detecting Extracapsular Spread of Cervical Lymph Node Metastases in HPV-Associated Oropharyngeal Cancer: A Systematic Review." Thesis, 2022. https://hdl.handle.net/2440/135910.
Повний текст джерелаThesis (MClinSc) -- University of Adelaide, Joanna Briggs Institute, 2022
Wu, Eric Longhua. "Translational assessment of primary tumor-derived cells." Thesis, 2014. https://hdl.handle.net/2144/14332.
Повний текст джерела