Готові списки джерел за темами / Organotin derivatives

Добірка наукової літератури з теми "Organotin derivatives"

Автор: Grafiati
Опубліковано: 18 травня 2024

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Статті в журналах з теми "Organotin derivatives"

1

Terraza, V. Fabricio, Darío C. Gerbino, and Julio C. Podestá. "Stereoselective Hydrostannation of Diacrylate and Dimethacrylate Esters of Galactaric Acid Derivatives: Cyclohydrostannation vs. Diaddition." Proceedings 9, no. 1 (November 14, 2018): 55. http://dx.doi.org/10.3390/ecsoc-22-05688.

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This paper reports a study on the free radical hydrostannation of ((4S,4′R,5R,5′S)-2,2,2′,2′-tetramethyl-[4,4′-bi(1,3-dioxolane)]-5,5′-diyl)bis(diphenyl methylene) diacrylate (1) and dimethacrylate (2) with triorganotin hydrides, R3SnH (R = Me, n-Bu, Ph). Preliminary investigations show that these reactions could lead to mixtures of products of cyclohydrostannation and/or mono- or diaddition according to the organotin hydrides employed and the reaction conditions used. The addition of Me3SnH to 1 afforded a mixture of three organotin compounds from which the pure new 13-membered macrodiolide 3 (48%) was obtained. The other two organotins could not be separated. The addition of n-Bu3SnH to diester 1 led to a mixture of two organotins, the one in major proportion (91%) being the product of diaddition 7. The minor product 6a (9%) could not be isolated pure. The hydrostannation of 1 with Ph3SnH led to one organotin: The product of diaddition 8. The hydrostannation of the dimethacrylate 2 with the organotin hydrides R3SnH (R = Me, n-Bu, Ph) under the same reaction conditions, led in the three cases to mixtures containing mainly diaddition products, and no cyclization products were detected. Some physical characteristics of the new compounds including selected values of 1H, 13C, and 119Sn NMRs are included.
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2

Kizlink, Juraj, and Vladimír Rattay. "Organotin derivatives of alkanedisulfonic acids." Collection of Czechoslovak Chemical Communications 52, no. 6 (1987): 1514–19. http://dx.doi.org/10.1135/cccc19871514.

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The preparation of dibutyltin and tributyltin alkanedisulfonates from alkyltin oxides and the corresponding alkanedisulfonic acids has been studied. The products, obtained in 56 – 74% yield, were tested as biocides against bacteria, yeasts, and moulds as well as fungicides against wood rot and their activity was compared with that of bis(tributyltin) oxide.
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3

Srivastava, Dileep K., and Lawrence Barton. "Organotin derivatives of hexaborane(10)." Organometallics 12, no. 7 (July 1993): 2864–68. http://dx.doi.org/10.1021/om00031a069.

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4

Hadi, Sutopo, Mona Dwi Fenska, Rama Aji Wijaya, Noviany Noviany, and Tati Suhartati. "Antimalarial Activity of Some Organotin(IV) Chlorobenzoate Compounds against Plasmodium falciparum." Mediterranean Journal of Chemistry 10, no. 3 (March 12, 2020): 213–19. http://dx.doi.org/10.13171/mjc0200312162sh.

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This paper reported the comparative study on antimalarial activity of some organotin(IV) derivatives with some chlorobenzoic acid derivatives used as the ligands. The compounds were synthesized by reacting the intermediate products of dibutyltin(IV) oxide, diphenyltin(IV) dihydroxide and triphenyltin(IV) hydroxide, with chlorobenzoic acid. The antimalarial activity was performed against Plasmodium falciparum. The results showed that the IC50 of the compounds tested were about the same with the chloroquine (2 x 10-3 µg/mL) used as the positive control, but unlike chloroquine which has been known to have resistance as antimalarial, these organotin(IV) compounds prepared are not resistant to the Plasmodium. The result also showed that the derivative of triphenyltin(IV) has higher IC50respective to others.
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5

Salam, M. A., M. A. Affan, Ramkrishna Saha, Fasihuddin B. Ahmad, and Norrihan Sam. "Synthesis, Characterization andIn VitroAntibacterial Studies of Organotin(IV) Complexes with 2-Hydroxyacetophenone-2-methylphenylthiosemicarbazone ()." Bioinorganic Chemistry and Applications 2012 (2012): 1–9. http://dx.doi.org/10.1155/2012/698491.

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Five new organotin(IV) complexes of 2-hydroxyacetophenone-2-methylphenylthiosemicarbazone [H2dampt, (1)] with formula [(dampt)] (where , (2); , (3); , (4);2, (5);2, (6)) have been synthesized by direct reaction of H2dampt (1) with organotin(IV) chloride(s) in absolute methanol. The ligand (1) and its organotin(IV) complexes (2–6) were characterized by CHN analyses, molar conductivity, UV-Vis, FT-IR,1H,13C, and119Sn NMR spectral studies. H2dampt (1) is newly synthesized and has been structurally characterized by X-ray crystallography. Spectroscopic data suggested that H2dampt (1) is coordinated to the tin(IV) atom through the thiolate-S, azomethine-N, and phenoxide-O atoms; the coordination number of tin is five. Thein vitroantibacterial activity has been evaluated againstStaphylococcus aureus, Enterobacter aerogenes, Escherichia coli, andSalmonella typhi. The screening results have shown that the organotin(IV) complexes (2–6) have better antibacterial activities and have potential as drugs. Furthermore, it has been shown that diphenyltin(IV) derivative (6) exhibits significantly better activity than the other organotin(IV) derivatives (2–5).
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6

Ibadi, Falih, Emad Yousif, Mohammed Al-Mashhadani, Nany Hairunisa, and Muna Bufaroosh. "Recent Studies on Cancer Cell's Inhibition by Organotin (IV) Materials: An Overview." Al-Nahrain Journal of Science 26, no. 2 (June 1, 2023): 23–29. http://dx.doi.org/10.22401/anjs.26.2.04.

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Анотація:
organotin (IV) compounds have been the focus of recent studies for their potential use in the treatment of cancer. This review provides an overview of recent studies on the inhibition of cancer cells by organotin (IV) materials. The literature suggests that organotin (IV) compounds can selectively target cancer cells and induce apoptosis, making them promising candidates for anticancer drugs. The review covers various types of organotin (IV) compounds, including those containing alkyl, aryl, and amino groups, and their mechanisms of action against cancer cells. Additionally, the study explores the potential toxicity and biocompatibility of these compounds and their derivatives, as well as their potential use in combination therapy. Overall, the results of recent studies suggest that organotin (IV) compounds show great potential for the treatment of cancer. However, more research is needed to fully understand their mechanism of action and potential side effects. The review highlights the need for continued investigation of these compounds and their derivatives to develop effective and safe anticancer therapies
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7

Rusu, M., L. Muresan, A. R. Tomsab, D. Rusuc, and Gh Marcua. "New Organotin Derivatives of Keggin Polyoxomolybdates." Synthesis and Reactivity in Inorganic and Metal-Organic Chemistry 30, no. 3 (March 2000): 499–511. http://dx.doi.org/10.1080/00945710009351777.

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8

Chauhan, H. P. S., S. Chourasia, Neeta Agrawal, and R. J. Rao. "Organotin(IV) Derivatives of Phthalanilic Acid." Synthesis and Reactivity in Inorganic and Metal-Organic Chemistry 24, no. 2 (February 1994): 325–38. http://dx.doi.org/10.1080/00945719408000113.

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9

Costantino, Andrea R., Jörg M. Neudörfl, Romina A. Ocampo, Laura A. Svetaz, Susana A. Zacchino, Liliana C. Koll, and Sandra D. Mandolesi. "Synthesis, Characterization and Antifungal Assessment of Optically Active Bis-organotin Compounds Derived from (S)-BINOL Diesters." Open Chemistry Journal 6, no. 1 (May 31, 2019): 34–20. http://dx.doi.org/10.2174/1874842201906010034.

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Background: Organotin(IV) derivatives have appeared recently as potential biologically active metallopharmaceuticals exhibiting a variety of therapeutic activities. Hence, it is important to study the synthesis of new organotin compounds with low toxicity that may be of pharmacological interest. Objectives: This study focuses on the synthesis of new bis-stannylated derivatives with C2 symmetry that could be tested as antifungal agents against two clinical important fungal species, Cryptococcus neoformans and Candida albicans. Methods: The radical addition of triorganotin hydrides (R3SnH) and diorganotin chlorohydrides (R2ClSnH) to bis-α,β-unsaturated diesters derived from (S)-BINOL led to the corresponding new bis-stannylated derivatives with C2 symmetry. Nine pure organotin compounds were synthesized with defined stereochemistry. Four of them were enantiomerically pure and four were diastereoisomeric mixtures. Results: All new organotin compounds were fully characterized, those with phenyl ligands bonded to tin were the most active compounds against both the strains (Cryptococcus neoformans and Candida albicans), with activity parameters of IC50 close to those of the reference drug (amphotericin B). Conclusion: Nine pure organotin compounds with C2 symmetry were synthesized with defined stereochemistry and their antifungal properties were tested against two clinical important fungi with IC values close to those of the reference drug. The structure-containing preferably two or three phenyl groups joined to the tin atom were highly active against both the strains compared with those possessing tri-n-butyl groups.
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10

Fatima Javed, Fatima Javed, Saqib Ali Saqib Ali, Khurram Shahzad Munawar Khurram Shahzad Munawar, Ali Haider Ali Haider, and N. A. Shah and Z. Rashid N A Shah and Z Rashid. "Synthesis, Structural Elucidation, and Therapeutic Screening of Organotin(IV) derivatives of oxo-ethyl carbonodithioate." Journal of the chemical society of pakistan 45, no. 4 (2023): 345. http://dx.doi.org/10.52568/001282/jcsp/45.04.2023.

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Exploring the therapeutic potential of organotin-based oxo-ethyl carbonodithioates, a series of organotin(IV) thiocarboamates (1-5) were synthesized with diverse alkyl and phenyl substituents. The chemical- composition, morphology, theoretical properties, and drug-DNA binding capabilities of the synthesized derivatives were performed by applying different characterization techniques like FT-IR, NMR (1H, 13C), AFM, DFT analysis, and UV-Vis spectroscopy respectively. The NMR data indicated six and four coordinated geometries, while the AFM results revealed smart surfaces concerning the grain size and root mean square (RMS) roughness, signifying catalytic and biocidal uses. The drug-DNA binding via intercalative mode of interaction with blue and red shifts was determined by using using UV spectroscopy. The in vitro biocidal capacity of selected complexes was evaluated against typical bacterial, fungal, cytotoxic, and leishmanial strains respectively. As a result of the surface and biocidal characterization, the synthesized complexes may be applied with greater potential in biomedical, pharmaceutical, infectious, catalysis, and cosmetics industries
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Більше джерел

Дисертації з теми "Organotin derivatives"

1

Chatterjee, Debesh Kumar. "Arylazo phenoxy derivatives of organotin compounds." Thesis, University of North Bengal, 1990. http://hdl.handle.net/123456789/757.

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2

Karanjai, Manju. "Organotin derivatives of carbonyl activated unsaturated organic compounds and their Lewis acid characters." Thesis, University of North Bengal, 1989. http://hdl.handle.net/123456789/765.

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3

Adhikari, Asis. "Organotin derivatives of some selected ligands containing and some related groups." Thesis, University of North Bengal, 1990. http://hdl.handle.net/123456789/756.

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4

Taylor, Oonah J. "A study of c-stannylated monosaccharide derivatives." Thesis, University of Aberdeen, 1988. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU602280.

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Анотація:
A series of C-stannylated monosaccharide derivatives were prepared and their chemistry studied. Derivatives having a hydroxyl group ? to tin, i.e. methyl 4,6-0- benzylidene-2(3)-deoxy-2(3)-triphenylstannyl-?-D-allopyranosides [(1) and (2)] and 6-deoxy-l,2-0-isopropylidene-6-triorganostannyl-?-D-glucofuranose (3, R=Me, 4, R=Ph) were prepared by reaction of appropriate triorgano-tin-lithiums with epoxy sugars. Reactions of 3 with TFA, acetyl chloride, benzoyl chloride, ethyl chloroformate, sulphur dioxide and TCNE produced via elimination, 5,-6- dideoxy-1,2-0-isopropylidene-?-D-xylo-hex-5-enofuranose (15). Methyl-tin bond cleavage in 3, with formation of C-(dimethylhalogenostannyl)- monosaccharides, occurred on reaction with I2, Br2 or Pd(COD)Cl2. The product from the I2 reaction was unstable in solution and gave the elimination product 15. MeLi gave no reaction, and both SnCl4 and ClSO3H gave Me3SnCl and acetone as the only recognisable products. The triphenylstannyl derivatives 1, 2 and 4 underwent phenyl-tin cleavage with electrophiles. The 1,2:5,6-di-0-isopropylidene-3-C-(triorganostannyl)methyl-?-D-allofuranoses [R=Me, (11), Bu (12) or Ph (13)] were prepared by reaction of an appropriate (triorganostannyl)methy1-lithium with a keto-sugar. Substitution to form the C-(iodostannylated) monosaccharide occurred for all compounds on reaction with iodine. No elimination was obtained on reaction of 11 with TFA, deprotection being the predominant route. The elimination product was isolated from the attempted Pd-catalysed coupling of 12 with PhCOCl and from reaction of the methoxymethyl ether derivative 14 (R=Ph) with PhLi. No reaction was observed on treatment of 12 and 13 with organolithium reagents. Derivatives having a hydroxyl group ? to tin, the l,2:5,6-di-0- isopropylidene-3-C-triorganostannyl-?-D-allofuranoses [R=Me (9) and Ph (10)] were prepared via reaction of a triorganostanny1-lithium with a keto- sugar. Compound 9 gave predominant methyltin cleavage with I2, was partially deprotected by TFA and gave the methyl-coupled product, Me-R, on reaction with carbon electrophiles, R-Y, under Pd-catalysis. The triphenyltin derivative 10, decomposed on treatment with TFA, gave no reaction with phenyl-lithium and pheny1-tin cleavage with I2. The ?-alkoxy derivatives, l,2:5,6-di-0-isopropylidene-3-0-(triorgano-stannyl)methyl-?-D-glucofuranose [R=Me (5) and Ph (6)] and (triorgano-stannyl)methyl 2,3:5,6-di-O-isopropylidene-?-D-mannofuranoside [R=Me (7) and Ph(8)] were prepared via alkylation of a free hydroxyl by iodomethyl-triorganostannane. The triphenyl derivatives underwent pheny1-tin cleavage with I2 and TFA, while tin-lithium exchange occurred with PhLi to give a lithiated sugar which was trapped by a variety of reagents. Compounds 5 and 7 gave competitive cleavage of Me-Sn and R*OCH2-Sn bonds on treatment with halogens. Reaction with TFA, acetyl chloride and SO2 gave predominant reaction at the protecting groups and no reaction was observed for benzoyl chloride and ethylchlorofornate. Tin(IV) chloride gave mainly methyl transfer to tin to form MeSnCl3 and the C-chlorodimethylstannyl derivatives. Treatment with Pd(COD)Cl2 however, gave competitive transfer of methyl group and sugar moiety from tin to palladium. The crystal structures of 10, 13 and the iodo-derivative of 12 were determined; and the results of biological testing of 10 and 13 for antitumour activity and 1, 6 and 8 for plant protection properties are reported.
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5

Das(, dutta) Sima. "Organotin derivatives of hydroxamic acids derived from dibasic carboxylic acid." Thesis, University of North Bengal, 1989. http://hdl.handle.net/123456789/755.

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6

SK, Kamruddin. "Studies on the organotion carboxylates and related compounds : syntheses, structures and properties, including biocidal properties of organotin derivatives of carboxylate ligands containing additional donor sites (e.g. N, S.)." Thesis, University of North Bengal, 1996. http://hdl.handle.net/123456789/770.

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7

Sarkar, Bipasa. "Synthesis of new organotin(iv) derivatives of thio semicarbazides and S N O containing related ligands : characterization and studies on the biocidal properties of the new compound with special reference to their agricultural application." Thesis, University of North Bengal, 2010. http://hdl.handle.net/123456789/1381.

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8

Leroux, Marcel Rainer [Verfasser], and Paul [Akademischer Betreuer] Knochel. "Late-stage functionalization of peptides and cyclopeptides using organozinc reagents and pyrrole protected 2-Aminoalkylzinc reagents for the enantioselective synthesis of amino derivatives / Marcel Rainer Leroux ; Betreuer: Paul Knochel." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2020. http://d-nb.info/1208150057/34.

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9

Metzger, Albrecht [Verfasser]. "Preparation and applications of benzylic zinc chlorides : lewis-acid promoted additions of organomagnesium and organozinc reagents to carbonyl derivatives ; transition metal-catalyzed cross-coupling reactions with methylthio-substituted N-heterocycles / von Albrecht Metzger." 2010. http://d-nb.info/1003615341/34.

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Частини книг з теми "Organotin derivatives"

1

Faried, Ahmad, Yulius Hermanto, Putri R. Amalia, and Hendrikus M. B. Bolly. "The Organoids: Derivations and Applications." In Organoid Technology for Disease Modelling and Personalized Treatment, 1–19. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-93056-1_1.

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2

Beletskaya, I. P. "Organotin and organosilicon compounds in cross-coupling, aromatic nucleophilic substitution, and addition reactions." In Chemistry and Technology of Silicon and Tin, 136–50. Oxford University PressOxford, 1992. http://dx.doi.org/10.1093/oso/9780198555803.003.0009.

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Abstract Abstract The reactions of organotin compounds with organic halides and acid halides catalysed by palladium complexes without phosphine ligands have been carried out under very mild conditions. These reactions afford biaryls, tolans, styrenes, dienes, and unsymmetrical ketones having various substituents. The synthesis of organotin compounds may be realized through the reactions of organic halides with hexaaryldistannanes catalysed by palladium and nickel complexes. The palladium-catalysed carbonylation of organic halides in the presence of organotin compounds of the series Alk SnNu (Nu= R, MeO, PhS, Et N, SnAik ) has proved to be a convenient method for the synthesis of ketones, derivatives of aromatic acids and o:-diketones.
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3

Murahashi, S. I. "Cross Coupling Using Organotin Compounds." In Three Carbon-Heteroatom Bonds: Nitriles, Isocyanides, and Derivatives, 1. Georg Thieme Verlag KG, 2004. http://dx.doi.org/10.1055/sos-sd-019-00266.

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4

Snaith, J. S. "Synthesis from Organomagnesium Derivatives and Organotin Halides." In Compounds of Group 14 (Ge, Sn, Pb), 1. Georg Thieme Verlag KG, 2011. http://dx.doi.org/10.1055/sos-sd-105-00071.

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5

Beng, Teo Soon, Teoh Siang Guan,, and Yeap Guan Yeow. "Organotin and inorganic tin complexes of some aromatic Schiff bases." In Chemistry and Technology of Silicon and Tin, 509–13. Oxford University PressOxford, 1992. http://dx.doi.org/10.1093/oso/9780198555803.003.0045.

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Abstract Organotin(IV), inorganic tin(II), and tin(IV) derivatives of 2-hydroxy- 1-naphthaldehyde- or salicyldehyde-substituted aniline Schiff bases have been prepared. The 1/1 and 1/2 molecular adducts have been characterized by elemental analyses, and by IR and NMR spectroscopic techniques, which indicate that coordination to tin occurs through the hydroxyl oxygen or the azomethine nitrogen, or through both these atoms. The crystal structure of the 1:2 diphenyltin dichloride adduct with 1-(4-methoxyphenylimino) methyl-2-naphthol is reported.
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6

Zard, Samir Z. "Organo-silicon, -germanium, and -mercury hydrides." In Radical Reactions in Organic Synthesis, 95–109. Oxford University PressOxford, 2003. http://dx.doi.org/10.1093/oso/9780198502418.003.0004.

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Abstract Silicon and germanium are in the same periodic column as tin, and the radical chemistry associated with these elements is in many ways qualitatively similar. The increased strength of the bonding to hydrogen and carbon translates into slower kinetics and less efficient chain processes as compared with organotin derivatives (Chatgilialoglu and Newcomb 1999). For example, hydrogen abstraction from tri n-butylgermane by a given carbon-centred radical is about 10-20 times slower than from tri-n-tributyl tin hydride (Johnston et al. 1985), and from triethylsilane and other simple silanes it becomes too slow to be generally useful.
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7

Schatz, J., and M. Seler. "Substitution Reactions Involving Organozinc Derivatives." In Fully Unsaturated Small-Ring Heterocycles and Monocyclic Five-Membered Hetarenes with One Heteroatom, 1. Georg Thieme Verlag KG, 2011. http://dx.doi.org/10.1055/sos-sd-109-00266.

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8

Subramanian, L. R. "From Organozinc Compounds." In Three Carbon-Heteroatom Bonds: Nitriles, Isocyanides, and Derivatives, 1. Georg Thieme Verlag KG, 2004. http://dx.doi.org/10.1055/sos-sd-019-00122.

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9

Schiltz, Pauline, Mengyu Gao, and Corinne Gosmini. "4 Organozinc reagents and cobalt." In Organozinc Derivatives and Transition Metal Catalysts, 141–78. De Gruyter, 2023. http://dx.doi.org/10.1515/9783110728859-004.

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10

Legros, Julien, and Bruno Figadère. "3 Organozinc reagents and iron." In Organozinc Derivatives and Transition Metal Catalysts, 117–40. De Gruyter, 2023. http://dx.doi.org/10.1515/9783110728859-003.

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Тези доповідей конференцій з теми "Organotin derivatives"

1

Jackson, Craig M. "A DEFINITION OF HEPARIN ANTICOAGULANT POTENCY APPLICABLE TO ALL HEPARINS AND HEPARIN-LIKE SUBSTANCES AND ITS PRACTICAL APPLICATION IN ASSAYING HEPARIN." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1642928.

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Heparins increase the rate of inactivation of proteinases by antithrombin without being consumed in the inactivation reaction. The anticoagulant activity of any heparin or heparin preparation is thus determined by the increase in the inactivaton rate which it produces. This rate increase is dependent on the concentration of the heparin in the sample and on some now well known structural properties of the individual heparin molecules that produce high affinity for antithrombin . All proteinases are not inactivated by antithrombin equally rapidly in the absence of heparin, nor are heparins and heparin derivatives of different molecular weight equally effective in the inactivation of the same proteinase. Under appropriate conditions, the observed rate constant (kObs) for the heparin catalyzed proteinase inactivation reaction is simply related to the intrinsic potencies and concentrations of the individual high affinity heparin molecules in the sample. The intrinsic potency of a high affinity heparin molecule is the efficiency with which it catalyzes the inactivation of the particular proteinase, e.g. Factor Xa or thrombin, i.e., it is a second order rate constant, (designated k*) . After k* has been determined from kobs for a known heparin or heparin preparation and a particular proteinase, the concentration of heparin in an unknown sample can be calculated from the equation[H] = [HAT] = kobs/k* In general terms, the appropriate conditions, i.e.,the antithrombin and proteinase concentrations, the pH, and ionic strength, required for this equation to be used are those conditions for which all of the high affinity heparin is bound to the antithrombin and pseudo first order kinetic behavior occurs. At very low heparin concentrations, a correction for the inactivation of the proteinase by antithrombin alone is necessary, but is easily made.Supported by Organon Teknika Corporation and an Established Investigator Award from the American National Red Cross
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