Готові списки джерел за темами / Oral lichen planu

Добірка наукової літератури з теми "Oral lichen planu"

Автор: Grafiati
Опубліковано: 14 березня 2023

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Статті в журналах з теми "Oral lichen planu"

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Hasan Zeynalova, Jala, Gulnara Salam Mammedova, Gunel Mammad Sultanova, İrada Arif Mammedxanova, Sevda Tariyel Huseynova, and Shahla Rafael Yusubova. "TREATMENT OF ORAL LICHEN PLANUS LICHEN PLANUS WITH PHOTODYNAMIC THERAPY." NATURE AND SCIENCE 14, no. 09 (November 23, 2021): 10–13. http://dx.doi.org/10.36719/2707-1146/14/10-13.

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Ağız boşluğunda yastı dəmirovun meydana gəlməsi ilə bağlı irəli sürülən bir sıra nəzəriyyələrə baxmayaraq, bu növ allergiya polietioloji hesab olunur.Ağız boşluğunun qırmızı yastı dəmirovu bir insandan digərinə keçə bilməz. Xəstəlik immun sisteminin naməlum səbəblərdən ağızın selikli qişasında hüceyrələrin strukturunun pozulması nəticəsində baş verir. Simptomlar adətən müalicə olunur, lakin ağızda qırmızı yastı dəmirovu olan insanlar mütəmadi həkim konsultasiyasına ehtiyac duyurlar. Açar sözlər: ağız boşluğunun qırmızı yastı dəmirovu, fotodinamik terapiya, metilen abısı
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Koneru, Dr Jyothirmai, Dr Mallika Mahalakshmi P, and Dr Ravindra Naik. "Management of Oral lichen Planus – A Review." Indian Journal of Applied Research 3, no. 3 (October 1, 2011): 289–90. http://dx.doi.org/10.15373/2249555x/mar2013/95.

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Timková, S., J. Minčík, M. Riznič, E. Ďurovič, and A. Konečná. "Lichen planus of the Oral Mucosa." Česká stomatologie/Praktické zubní lékařství 118, no. 1 (March 1, 2018): 3–7. http://dx.doi.org/10.51479/cspzl.2018.015.

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Timková, S., J. Minčík, M. Riznič, E. Ďurovič, and A. Konečná. "Lichen planus of the Oral Mucosa." Česká stomatologie/Praktické zubní lékařství 118, no. 1 (March 1, 2018): 3–7. http://dx.doi.org/10.51479/cspzl.2018.015.

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Dermawan, I. G. N. Putra, and I. Nyoman Gede Juwita Putra. "MANAGEMENT OF ORAL LICHEN PLANUS TRIGGERED BY STRESS." Interdental Jurnal Kedokteran Gigi (IJKG) 17, no. 1 (June 22, 2021): 27–33. http://dx.doi.org/10.46862/interdental.v17i1.1949.

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Introduction: Oral lichen planus (OLP) is a mucocutaneous disorder that rarely occurs around us and only involves the layer of the stratified squamous epithelium. Oral lichen planus is more common in women aged 30-65 years. The etiology of this disorder is not yet known, but there are several predisposing factors that play a role, such as hepatitis C virus infection, food, drugs, malignancy, and psychological factors. Purpose: This case report aims to describe the treatment of stress-induced OLP. Case Report: A 46-year-old man presented with complaints of stinging on the inner right and left cheeks for one month ago. The patient admits that he has a lot of thoughts related to family problems. It is found that the lesion resembles a white streak with redness that forms in the intraoral area. Case management: The patient was given therapy in the form of topical corticosteroids and consulted to psychiatry and got improvement after 1 week of treatment. Discussion: The treatment of OLP lesions is a treatment that requires collaboration between the dentist, the patient and the patient's family. Corticosteroid therapy is the gold standard treatment given to people with OLP. Corticosteroids are widely used in medicine because of their strong effect and fast anti-inflammatory reaction. Corticosteroids are widely used for the management of inflammatory diseases. Besides supporting therapy in consultation with a psychologist or psychiatrist to deal with stress disorders. Conclusion: Treatment of OLP lesions is a complex treatment. Corticosteroid therapy, both topical and systemic, is the most appropriate therapy and the role of a psychologist or psychiatrist is needed in managing patient stress to increase the percentage of patient recovery.
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Janovská, M., and Š. Podzimek. "ORAL LICHEN PLANUS - CURRENT POINT OF VIEW." Česká stomatologie/Praktické zubní lékařství 119, no. 4 (December 1, 2019): 100–111. http://dx.doi.org/10.51479/cspzl.2019.026.

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Janovská, M., and Š. Podzimek. "ORAL LICHEN PLANUS - CURRENT POINT OF VIEW." Česká stomatologie/Praktické zubní lékařství 119, no. 4 (December 1, 2019): 100–111. http://dx.doi.org/10.51479/cspzl.2019.026.

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Padmapriya, N., and K. Karthikeyan. "Oral lichen planus with linear lichen planus: a rare association." International Journal of Research in Dermatology 5, no. 2 (April 26, 2019): 429. http://dx.doi.org/10.18203/issn.2455-4529.intjresdermatol20191776.

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<p class="abstract">Lichen planus (LP) is a papulosquamous disorder with both cutaneous and mucosal manifestation. Linear lichen planus is rare variant of lichen planus which occurs in the extremities. Oral lichen planus is another variant of lichen planus. Coexistence of linear lichen planus with oral lichen planus is rare and only one case has been reported before this case. A 35 year old female presented with hyperpigmented linear lesion in the leg and whitish plaques in the oral cavity. Biopsy of the skin lesions showed features of lichen planus. The patient was started on topical steroids and oral hydroxychloroquine. Patient responded to treatment.</p>
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Bradić-Vasić, Marija, Ana Pejčić, Milena Kostić, Ivan Minić, Radmila Obradović, and Ivana Stanković. "Lichen planus: Oral manifestations, differential diagnosis and treatment." Acta stomatologica Naissi 36, no. 81 (2020): 1980–94. http://dx.doi.org/10.5937/asn2081980b.

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Introduction: Some of the typical skin diseases, such as Pemphigus vulgaris, Pemphigoid mucosae oris, Erythema exudativum multiforme, Sclerodremia, Dermatitis herpetiformis-Duhring and Lichen planus, can cause swelling and irritation in mucous membranes of the oral cavity. Aim: The aim of the study was to precise diagnosis and treatment of oral Lichen planus manifestations. Methods: Analyzing the literature data and the experience of clinicians, the most common oral lichen planus manifestations were investigated. Results: This disease most commonly occurs in middle-aged patients (30-60 years) and is more common in women than in men. Oral Lichen planus is rarely seen in children. The disease presents in 0.5% to 2% of the population. Clinical history established the relation between oral Lichen planus and oral carcinoma, and therefore this disease should be considered a precancerous lesion. Conclusion: Dermatoses in the mouth are localized most often in the oral mucosa, both at the height of the occlusal line and in the mucous membrane of the retromolar area, but they can also occur in the mucous membranes of the tongue, the floor of the mouth and lips.
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Ion, Daniela I., and Jane F. Setterfield. "Oral Lichen Planus." Primary Dental Journal 5, no. 1 (February 2016): 40–44. http://dx.doi.org/10.1177/205016841600500104.

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Lichen planus (LP) is a relatively common autoimmune T-cell-mediated disease of unknown aetiology affecting the mucous membranes, skin and nails. Its prevalence varies between 0.5 and 2.2% of the population in epidemiological studies with a peak incidence in the 30–60 years range and with a female predominance of 2:1.1 Mucosal lichen planus tends to follow a chronic course with acute exacerbations. Spontaneous remission of oral lichen planus (OLP) is uncommon, and indeed mucosal LP may become worse with time. In contrast, cutaneous lichen planus may follow a milder clinical course though some variants may be severe such as those affecting the palms and soles and the scalp and the genital tract in females (vulvovaginal gingival LP) where scarring leads to significant complications. It is important to identify those cases that may be drug induced or be associated with a contact allergic or irritant reaction (lichenoid reaction) or the rarer oral presentation of discoid lupus erythematosus. There is a very small risk of malignancy (approximately 1:200 patients/year) associated with oral lichen planus; thus patients should be informed that long term monitoring via their general dental practitioner is appropriate. This review will focus on the clinical presentation and management of oral lichen planus.
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Більше джерел

Дисертації з теми "Oral lichen planu"

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Siponen, M. (Maria). "Oral lichen planus – etiopathogenesis and management." Doctoral thesis, Oulun yliopisto, 2017. http://urn.fi/urn:isbn:9789526214702.

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Abstract Oral lichen planus (OLP) is a chronic immune-mediated mucosal disease with unknown etiology. According to the current view, the pathogenesis of OLP involves activation of T-cell mediated immunity against the epithelial keratinocytes. A proportion of OLP patients are affected by painful symptoms, and the risk of oral cancer is increased in OLP. There is no curative treatment for OLP. Topical corticosteroids are used most commonly in the management of OLP. However, the evidence base for the effectiveness of any therapy is weak. The objective of this thesis was to study novel aspects of OLP etiopathogenesis and management. An epidemiologic, retrospective case-control study was conducted to determine whether systemic diseases, in particular thyroid diseases, are associated with OLP. In addition, a randomized controlled trial comparing the effectiveness of topical tacrolimus, triamcinolone acetonide and placebo in symptomatic OLP was carried out. Furthermore, immunohistochemical expression of toll-like receptors 4 and 9, hyaluronan and its principal receptor CD44 antigen, hyaluronan synthases 1-3, hyaluronidases 1-2 and cathepsin K was studied in OLP tissue samples and in healthy oral mucosa. The effect of topical tacrolimus on the expression of these molecules in OLP was also studied. The results of the present study showed that a history of hypothyroidism was associated with an approximately twofold risk of having OLP. Furthermore, both tacrolimus and triamcinolone acetonide were more efficient than placebo in reducing the signs and symptoms of OLP. No statistically significant differences were noted in the efficacy between tacrolimus and triamcinolone acetonide. In addition, the expression of the studied molecules was altered in the epithelium or stroma in OLP compared to healthy oral mucosa. Tacrolimus treatment decreased the expression of CD44 antigen in the stroma and the expression of cathepsin K in the epithelium in OLP. In conclusion, the present study extends our knowledge about systemic associated factors and management of OLP. In addition, the results improve our understanding of molecular level changes that occur in OLP
Tiivistelmä Suun punajäkälä on krooninen immuunivälitteinen limakalvotauti, jonka etiologia on tuntematon. Taudin syntymekanismiin liittyy tämän hetkisen näkemyksen mukaan T-soluvälitteisen immuniteetin aktivoituminen epiteelin keratinosyyttejä vastaan. Suun punajäkälä aiheuttaa osalle potilaista kivuliaita oireita ja lisää suusyövän riskiä. Parantavaa hoitoa tautiin ei ole. Yleisimmin suun punajäkälän oireiden hoidossa käytetään paikallisia kortikosteroidivalmisteita. Kuitenkin eri hoitomuotojen tehosta on vain heikkoa näyttöä. Tämän väitöskirjatyön tarkoituksena oli tutkia uusia näkökohtia liittyen suun punajäkälän etiopatogeneesiin ja hoitoon. Epidemiologisessa tapaus-verrokkitutkimuksessa selvitettiin, liittyvätkö yleissairaudet, erityisesti kilpirauhassairaudet, suun punajäkälään. Lisäksi satunnaistetussa kontrolloidussa tutkimuksessa verrattiin paikallisen takrolimuusin, triamsinoloniasetonidin ja lumelääkkeen tehoa oireisesta suun punajäkälästä kärsivillä potilailla. Tutkimuksessa selvitettiin myös tollin kaltaisten reseptorien 4 ja 9, hyaluronaanin ja sen pääasiallisen reseptorin CD44-antigeenin, hyaluronaanisyntaasien 1–3, hyaluronidaasien 1–2 sekä katepsiini K:n immunohistokemiallista ilmentymistä suun punajäkälänäytteissä ja terveessä suun limakalvossa. Lisäksi tutkittiin takrolimuusihoidon vaikutusta näiden molekyylien ilmentymiseen suun punajäkälässä. Tämän tutkimuksen tulokset osoittivat, että kilpirauhasen vajaatoimintaan liittyi noin kaksinkertainen riski sairastaa suun punajäkälää. Lisäksi havaittiin, että suun punajäkälässä sekä takrolimuusi että triamsinoloniasetonidi ovat tehokkaampia kuin lumelääke oireiden ja kliinisen taudinkuvan lievittämisessä. Takrolimuusin ja triamsinoloniasetonidin tehossa ei todettu tilastollisesti merkitseviä eroja. Lisäksi suun punajäkälänäytteissä tutkittujen molekyylien ilmentyminen oli muuttunut joko epiteelissä tai stroomassa verrattuna terveeseen limakalvoon. Takrolimuusihoito vähensi CD44-antigeenin ilmentymistä stroomassa ja katepsiini K:n ilmentymistä epiteelissä suun punajäkälässä. Yhteenvetona voidaan todeta, että tämä tutkimus lisää tietoa suun punajäkälään liittyvistä systeemisistä tekijöistä ja suun punajäkälän hoidosta. Lisäksi löydökset lisäävät ymmärtämystä suun punajäkälässä tapahtuvista molekyylitason muutoksista
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Marshall, Alison Shona. "The role of chemokines in oral lichen planus." Thesis, University College London (University of London), 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.413748.

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Zhao, Zhen Zhen. "Mast cell-related mechanisms in oral lichen planus /." [St. Lucia, Qld.], 2001. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe16304.pdf.

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Jungell, Peter. "Oral lichen planus an ultrastructural and immunohistochemical study /." Helsinki : [s.n.], 1989. http://catalog.hathitrust.org/api/volumes/oclc/21180820.html.

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Анотація:
Thesis--University of Helsinki, 1989.
At head of title: Department of Oral Surgery, Institute of Electron Microscopy, University of Helsinki, and Fourth Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland. Includes bibliographical references (p. 58-71).
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Lage, Denise 1979. "Doenças liquenoides da pele e mucosa oral = análise histológica e imuno-histoquímica = Lichenoid diseases of the skin and oral mucosa : histological and immunohistochemical analysis." [s.n.], 2014. http://repositorio.unicamp.br/jspui/handle/REPOSIP/312892.

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Анотація:
Orientador: Maria Letícia Cintra
Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas
Made available in DSpace on 2018-08-24T06:34:44Z (GMT). No. of bitstreams: 1 Lage_Denise_D.pdf: 12121159 bytes, checksum: f93ebe72b9dc8acf40f7ff2245de6a21 (MD5) Previous issue date: 2014
Resumo: O líquen plano (LP) pode afetar a pele e/ou as mucosas. Histologicamente apresenta infiltrado linfo-histiocitário na junção epitélio-tecido conjuntivo e apoptose de células epiteliais basais. No LP oral (LPO), ocorre erosão frequente pela maior intensidade da necrose. O LP cutâneo (LPC) e o LPO apresentam características histopatológicas similares, mas o curso clínico é diverso. O LPC costuma ter seu curso limitado, enquanto o LPO é frequentemente recidivante. A erupção liquenoide a droga (ELD) desenvolve-se após semanas da ingestão do medicamento e a resolução do quadro é lenta após a interrupção, dificultando o diagnóstico diferencial com o LP idiopático. Os achados clínicos e histológicos podem ser indistinguíveis daqueles do LP, mas a patogênese da ELD não é conhecida. Diferenças locais no sistema imune da mucosa oral e pele poderiam explicar a diversidade no comportamento clínico do LP. Quanto à ELD, há poucas publicações sobre as alterações imunes que atuam no seu desenvolvimento. A citotoxidade celular é mediada, dentre outros mecanismos, por grânulos contendo granzima B e perforina, produzidos por linfócitos T citotóxicos e células natural killers. Com o objetivo de estudar a citotoxicidade celular na patogênese destas doenças, foram analisadas 29 amostras de LPO, 16 de LPC e 6 de ELD. Os cortes foram corados pela H&E e técnica de imuno-histoquímica, para a demonstração de linfócitos CD4 e CD8, macrófagos HAM 56+ e MAC 387+, granzima B, perforina e ICAM-1. As amostras de LPO apresentaram maior densidade de células granzima B+ e perforina+, em comparação às do LPC. Nos dois grupos de doenças, quanto maior era o número de células perforina+, maior era o de células granzima B+. Maior número de células CD4-positivas foi encontrado nas lesões ativas, quando comparado com o das regressivas, no LPO, mas não no LPC. À comparação entre o LPC e a ELD, quanto maior o número de células CD8-positivas, maior era o número de células que expressavam a perforina no grupo LPC. Quanto maiores eram os valores da granzima B, maiores os da perforina, no grupo LPC. Quanto maiores eram os valores da granzima B, maiores os de células apoptóticas agregadas, no grupo da ELD. Nas amostras do LPC, quanto maiores os valores das células T, maiores os dos macrófagos HAM56-positivos e vice-versa. Nas amostras da ELD, foi encontrada correlação negativa entre o número de células T e o de histiocitos jovens (MAC 387+). Havia correlação positiva entre o número de células T e o de células CD8, no grupo da ELD. O mesmo não ocorreu, no grupo do LPC. Concluindo, a expressão aumentada dos grânulos citotóxicos no LPO pode estar associada à maior gravidade da doença na mucosa. Os resultados favorecem um papel mais importante da granzima B e linfócitos TCD8+, no mecanismo patogenético da ELD, comparativamente com o da perforina, de maior importância no LPC. É possível que a ação da granzima B esteja ligada ao número abundante de clusters encontrado na ELD. Embora o LPC e a ELD apresentem semelhanças clínicas e histológicas, a etiopatogênese parece ser distinta
Abstract: Lichen planus (LP) can affect the skin and/or mucous membranes. Histologically it presents lymphohistiocytic infiltrate in the epithelium-connective tissue junction and apoptosis of basal epithelial cells. In oral LP (OLP), erosion occurs frequently by higher intensity of necrosis. Cutaneous LP (CLP) and OLP present similar histopathological features, but the clinical course is diverse. Spontaneous remission is common in CLP, but OLP follows a prolonged course, with periods of remission and relapse. Lichenoid drug eruption (LDE) develops after weeks of drug intake and the resolution of lesions is slow after drug discontinuation, hampering the differential diagnosis with (idiopathic) LP. Clinical and histological findings of LDE may be indistinguishable from those of LP, but LDE pathogenesis is poorly understood Local differences in the immune system of the skin and oral mucosa could explain the diversity in the clinical behavior of CLP and OLP. Regarding LDE, there are few publications on the immune changes that act in its development. Cellular cytotoxicity is mediated, among other mechanisms, by granules containing perforin and granzyme B, produced by cytotoxic T lymphocytes and NK cells. In order to study cellular cytotoxicity in the pathogenesis of these diseases, we analyzed 29 samples of OLP, 16 of CLP and 6 of LDE. The sections were stained for H&E and immunohistochemically targeted with CD4, CD8, HAM 56, MAC387, granzyme B, perforin and ICAM-1. OLP specimens exhibited higher density of cytotoxic granules (perforin and granzyme B) when compared with CLP. In both groups of diseases, the greater the number of perforin+ cells, the greater was the number of granzyme B+ cells. Increased number of CD4+ cells was found in active lesions as compared with the regressive ones in OLP but not in the CLP. The comparison between CLP and LDE revealed that the greater the number of CD8+ cells, the greater the number of cells expressing perforin in CLP group. The higher were the values of granzyme B, the higher the perforin values in the CLP group; the higher were the values of granzyme B, the higher the number of clusters of apoptotic cells in the LDE group. Within CLP group, the higher were the values of T cells, the greater the number of HAM56+ macrophages and vice versa. In LDE samples, negative correlation was found between the number of T cells and young histiocytes (MAC 387+). There was a positive correlation between the number of T cells and CD8 cells in LDE group, but not in CLP group. Concluding, increased expression of cytotoxic granules in OLP may be associated with greater mucosa severity. The results favor a greater role of granzyme B and CD8+ lymphocytes in the pathogenic mechanism of LDE, when compared with perforin, of greater importance in CLP. It is possible that the action of granzyme B is connected to the abundant number of clusters found in LDE. Although CLP and LDE present clinical and histological similarities, the etiopathogenesis appears to be distinct
Doutorado
Anatomia Patologica
Doutora em Ciências Médicas
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Erfanian, Nima, and Kaiser Ghodbeni. "Clinical Description of Patients Diagnosed with Oral and Genital Lichen Planus, a Register Study." Thesis, Umeå universitet, Institutionen för odontologi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-143876.

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ABSTRACT   The aim of this study is to chart a cohort of patients in the county of Västerbotten in Sweden who have been diagnosed with lichen planus. In addition to charting, the cohort has also been compared to similar previously studied groups.   The studied group consist of patients who have been referred to the Department of Medical Biosciences and Pathology between years 2009-2015 with suspicious diagnosis of LP.   After exclusion, 214 patients remained of which 130 were diagnosed with Oral LP and 84 with Genital LP. Different data such as age, medications and diseases was extracted from the dental journals.   In this cohort women were more likely to be affected by LP. The mean age for females was 63 years and 53 years for men. In the studied group 17 % were being treated for hypertension, 14 % were treated with 5 or more different medications. Tobacco use was found in 17 % and 12 % were diagnosed with an autoimmune disease.   The results from the studied cohort were in accordance with similar populations in previous studies. There is an undergoing discussion whether OLP and LP are the same disease that affects different sites.
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Olivieri, Charles-Vivien. "Inflammations orales et infection par le virus d’Epstein-Barr : vers un nouveau paradigme en pathogenèse orale." Thesis, Université Côte d'Azur (ComUE), 2018. http://www.theses.fr/2018AZUR4201/document.

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La cavité buccale constitue une porte d’entrée et un site réservoir majeur pour une diversité de virus. Mis à part l’herpèsvirus simplex, peu d’études virologiques détaillent le rôle des virus pathogènes de la sphère orale dont le virus d’Epstein-Barr. Le consensus est que les inflammations orales surviennent principalement en réaction à des infections bactériennes et fongiques provoquant une dysbiose du biofilm oral. Toutefois, ce modèle n’est pas parfait et il explique mal les récidives observées après décontamination, le découplage entre dysbiose et poussées inflammatoires, la proximité de dents atteintes et saines dans un environnement bactérien similaire. L’hypothèse d'un mécanisme synergique combinant virus et bactéries a été proposée pour la parodontite. Selon ce modèle, l’action complémentaire des 2 types d’agents infectieux sur le microenvironnement immunitaire favoriserait la chronicité inflammatoire et l’évolution de la maladie. Nos travaux se concentrent sur l’étude de l’infection de la cavité orale par EBV. EBV est un virus ubiquitaire infectant l’homme de manière persistante. La cavité orale est le site privilégié pour sa réplication avec une production salivaire quasi-constante. Outre un rôle transformant majeur, l’implication de EBV est aussi suspectée pour plusieurs maladies inflammatoires. Tout d’abord, nous nous sommes intéressés au lichen plan oral (LPO), une maladie auto-immune dont l'étiopathogénie n’est pas clairement établie. Sur des biopsies de patients atteints de LPO (n=99), nous avons démontré par hybridation in situ que le LPO est fréquemment infecté par EBV (74%), notamment les formes cliniques érosives. Nous montrons que le degré d’infiltration des lésions par des cellules infectées par EBV (EBV+) est corrélé avec les paramètres inflammatoires et que les cellules EBV+ infiltrées sont des plasmocytes. Cela apporte un élément nouveau dans la mesure où les plasmocytes sont reconnus comme des cellules immunitaires régulatrices majeures. Nous décrivons des profils cytokiniques différents entre LPO infectés ou non, sans qu’il soit possible à ce stade de pouvoir impliquer directement les plasmocytes. Nous confirmons par microscopie électronique que les plasmocytes hébergent les stades tardifs du cycle d’EBV et produisent des virions dans le LPO, suggérant un mécanisme d’amplification locale de l'infection. Ensuite, nous nous sommes intéressés à la parodontite, maladie inflammatoire chronique commune qui détruit la structure parodontale et provoque le déchaussement dentaire. Cette maladie est clairement identifiée comme facteur aggravant de nombreuses maladies systémiques. Nos études avaient déjà mis en évidence un lien direct entre infection EBV et la sévérité de la parodontite. Mes travaux ont permis de montrer que le parodonte inflammatoire est infiltré par des cellules EBV+ qui semblent être majoritairement des plasmocytes. La présence de plasmocytes producteurs de virus au sein de la lésion inflammatoire pourrait expliquer l’infection des épithéliums adjacents. De plus, une étude clinique menée sur une petite cohorte de patients traités pour parodontite met en évidence une corrélation entre la diminution de la charge EBV salivaire et l’amélioration clinique de patients après traitement. Si ce résultat se confirme, il constituerait un argument supplémentaire en faveur d’une contribution de l’infection parodontale par EBV à la globalité de la charge EBV salivaire. En conclusion, nos données mettent en évidence la présence quasi constante d’EBV dans deux types de lésions orales inflammatoires. Cette infection virale contribue à aggraver une situation inflammatoire locale associée ou pas à une dysbiose bactérienne. L’observation majeure concerne la présence, souvent massive, de plasmocytes infectés dont le rôle reste à identifier. Ces observations constituent des avancées significatives qui permettent d’étayer un nouveau modèle de pathogénie orale associant virus et bactéries
The oral cavity is a major entry point and reservoir site for a variety of viruses. Apart from herpesvirus simplex, few virological studies detail the role of oral pathogenic viruses, including Epstein-Barr virus. The consensus is that oral inflammation occurs mainly in response to bacterial and fungal infections causing dysbiosis of the oral biofilm. However, this model is not perfect and does not explain well the recurrences observed after decontamination, the decoupling between dysbiosis and inflammatory outbreaks, the proximity of affected and healthy teeth in a similar bacterial environment. The hypothesis of a synergistic mechanism combining viruses and bacteria has been proposed for periodontitis. According to this model, the complementary action of the 2 types of infectious agents on the immune microenvironment would promote inflammatory chronicity and disease progression. Our work focuses on the study of oral cavity infection with EBV. EBV is a ubiquitous virus that persistently infects humans. The oral cavity is the preferred site for its replication with almost constant saliva production. In addition to a major transformative role, EBV's involvement is also suspected for several inflammatory diseases. First, we focused on oral plan lichen (OPL), an autoimmune disease whose etiopathogeny is not clearly established. On biopsies of patients with OPL (n=99), we demonstrated by in situ hybridization that OPL is frequently infected with EBV (74%), particularly in erosive clinical forms. We show that the degree of infiltration of lesions by EBV-infected cells (EBV+) is correlated with inflammatory parameters and that the infiltrated EBV+ cells are plasma cells. This brings a new element to the extent that plasma cells are recognized as major regulatory immune cells. We describe different cytokinic profiles between infected and uninfected OPL, although it is not possible at this stage to directly involve plasma cells. We confirm by electron microscopy that plasma cells host the late stages of the EBV cycle and produce virions in the OPL, suggesting a local amplification mechanism of infection. Then, we focused on periodontitis, a common chronic inflammatory disease that destroys the periodontal structure and causes tooth loosening. This disease is clearly identified as an aggravating factor in many systemic diseases. Our studies had already shown a direct link between EBV infection and the severity of periodontitis. My work has shown that the inflammatory periodontium is infiltrated by EBV+ cells, which appear to be predominantly plasma cells. The presence of virus-producing plasma cells within the inflammatory lesion may explain the infection of adjacent epithelia. In addition, a clinical study conducted on a small cohort of patients treated for periodontitis showed a correlation between the decrease in salivary EBV load and the clinical improvement of patients after treatment. If this result is confirmed, it would be an additional argument in favour of a contribution of periodontal EBV infection to the overall salivary EBV burden. In conclusion, our data show the almost constant presence of EBV in two types of inflammatory oral lesions. This viral infection contributes to worsening a local inflammatory situation associated or not with bacterial dysbiosis. The main observation concerns the presence, often massive, of infected plasma cells whose role remains to be identified. These observations represent significant advances that support a new model of oral pathogenesis combining viruses and bacteria
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Camargo, Alessandra Rodrigues de. "Líquen plano oral associado a Hepatite C." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/23/23139/tde-20032015-154058/.

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O presente estudo teve como objetivo verificar a associação entre o líquen plano oral (LPO) e a infecção de hepatite C (HCV) crônica em duas populações distintas do município de São Paulo. Foram avaliados um total de 308 pacientes distribuídos em dois grupos de estudo: grupo HCV composto por 275 pacientes (132 homens e 143 mulheres; idade média = 49,8 anos) com infecção de HCV crônica; e o grupo LPO composto por 33 pacientes (10 homens e 23 mulheres; idade média = 52,9 anos) com LPO. No grupo HCV o diagnóstico da infecção crônica foi estabelecido através de sorologia para anti-HCV (MEIA, kit AxSYM® HCV version 3.0, Abbott Laboratories, North Chicago, Illinois) confirmado pela pesquisa de RNA-HCV através do teste PCR qualitativo (Cobas Amplicor HCV MonitorTM test, version 2.0, Roche Diagnostic Systems, NJ, USA). No grupo LPO o diagnóstico para lesões orais seguiu critérios estabelecidos pela World Health Organization (WHO) em 1978 e posteriormente modificados por van der Meij e van der Waal em 2003. Como critérios de exclusão para o grupo HCV pacientes que fizeram uso de interferon e/ou ribavirina por um período menor que 6 meses foram excluídos do estudo, assim como pacientes que encontravam-se em terapia antiviral para HCV. Neste grupo a presença de co-infecções - HIV, HBV, HTLV - também foi desconsiderada. No grupo LPO pacientes com diagnóstico clínico sugestivo de reação liquenóide por uso a drogas (RLD) e reação liquenóide por contato (RLC) foram excluídos da amostra, assim como pacientes tratados local ou sistemicamente para LPO por um período menor que 6 meses. Casos com achados histopatológicos de displasia liquenóide também foram desconsiderados. Para análise dos resultados duas comparações foram efetuadas: (1) no grupo HCV a prevalência de LPO foi determinada e comparada com a prevalência de LPO em nossa instituição (grupo controle); (2) no grupo LPO a prevalência da infecção de HCV foi determinada e comparada com a prevalência da infecção de HCV na população de São Paulo. A prevalência de LPO em pacientes com HCV crônica (grupo HCV) foi de 2,18% e de 1,54% no grupo controle (P = 0,39). A prevalência de HCV crônica em pacientes com diagnóstico de LPO (grupo LPO) foi de 3,03% e de 1,42% na população em geral (P = 0,39). Nenhuma diferença estatisticamente significante foi verificada quando os grupos foram comparados. Em nossa análise não foi verificada associação entre o LPO e a infecção de HCV crônica, nas duas populações avaliadas no município de São Paulo.
The objective of the present study was to verify the association between oral lichen planus (OLP) and chronic hepatitis C virus infection (HCV) in two distinct populations in the municipality of São Paulo. A total of 308 patients were evaluated distributed in two study groups: group HCV, comprising 275 patients (132 men and 143 women; average age = 49.8 years old) with chronic HCV infection; and group OLP, comprising 33 patients (10 men and 23 women; average age = 52.9 years old) with OLP. In group HCV, the diagnosis of chronic infection was established through serology for anti-HCV (MEIA, kit AxSYM® HCV version 3.0, Abbott Laboratories, North Chicago, Illinois) confirmed by RNA-HCV research through qualitative PCR testing (Cobas Amplicor HCV MonitorTM test, version 2.0, Roche Diagnostic Systems, NJ, USA). In group OLP, the diagnosis of oral lesions followed the criteria established by the World Health Organization (WHO) in 1978 and later modified by van der Meij and van der Waal in 2003. As exclusion criteria for group HCV, patients that made use of interferon and/or ribavirin for a period below 6 months were excluded from the study, as well patients that were under antiviral treatment for HCV. In this group the presence of co-infections - HIV, HBV, HTLV - was also discarded. In group OLP, patients with clinical diagnosis suggestive of drug-induced lichenoid reactions (DLR) and oral lichenoid lesions related to dental materials (LLDM) were excluded from the sample, as well as patients treated locally or systemically for OLP for a period below 6 months. Cases with histopathological findings of lichenoid dysplasia were also discarded. For result analysis, two comparisons were conducted: (1) in group HCV, OLP prevalence was determined and compared to OLP prevalence in our institution (control group); (2) in group OLP, the prevalence of HCV infection was determined and compared to the prevalence of HCV infection in the São Paulo population. OLP prevalence in patients with Chronic HCV (group HCV) was 2.18% and 1.54% in the control group (P = 0.39). Chronic HCV prevalence in patients with a diagnosis of OLP (group OLP) was 3.03% and 1.42% in the general population (P = 0.39). No statistically significant difference was verified when groups were compared. Our study did not verify an association between OLP and chronic HCV infection in the two populations assessed in the municipality of São Paulo.
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9

Zwet, Marwa. "The extent of the role of apoptosis in oral lichen planus – a morphometric study." University of the Western Cape, 2016. http://hdl.handle.net/11394/5491.

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Magister Chirurgiae Dentium (MChD)
Oral lichen planus (OLP) is a T-cell mediated chronic inflammatory disease with different clinical types that remains inscrutable in respect of its pathogenetic mechanisms and effective therapy. Increased apoptosis may influence the histopathological criteria of oral lichen planus (decrease in thickness of the epithelium and band of inflammatory infiltrate). Null hypothesis: The apoptotic rate does not correlate with a decrease in the epithelial thickness as well as the thickness of the band of inflammatory infiltrate in OLP. Aim: The present study aims to quantify apoptotic activity and to correlate the apoptotic rate with epithelial thickness as well as thickness of the inflammatory infiltrate of OLP cases diagnosed at Tygerberg Hospital from 2006 – 2015. Further, the epithelial thickness and thickness of the inflammatory infiltrate were also assessed for their association, if any. Materials and Methods: The study sample comprised 17 diagnostically verified cases of OLP. Sections stained with Haematoxylin and Eosin (H&E) were used to identify and count the number of apoptotic cells as well as measure the thickness of epithelium and the thickness of the lymphocytic inflammatory infiltrate by using software morphometric analysis (Zen Blue lite 2012). Statistical analysis was applied to analyse the correlation between apoptotic cells and histopathological features of OLP. Results: The present study's results showed no statistically significant association between the apoptotic rate, the epithelial thickness and the thickness of the lymphocytic inflammatory infiltrate.
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Altersved, Karin, and Agneta Wallén. "Patienters upplevelse av oral hälsa vid diagnosen erosiv oral lichen planus : En kvalitativ studie." Thesis, Karlstads universitet, Fakulteten för hälsa, natur- och teknikvetenskap (from 2013), 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-26876.

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Книги з теми "Oral lichen planu"

1

Migliari, Dante Antonio. Critical Thoughts on Oral Lichen Planus. Nova Science Publishers, Incorporated, 2020.

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Agrawal, Rahul, Akhilesh Chandra, and Romi Agrawal. Oral Lichen Planus: Past and Present. LAP LAMBERT Academic Publishing, 2013.

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Upadhyay, Ram Ballabh, Juhi Upadhyay, and Sunitha Carnelio. oxidatve stress in oral lichen planus and oral lichenoid reactions: Oxidative stress and antioxidant defence in oral lichen planus and oral lichenoid reactions. LAP Lambert Academic Publishing, 2012.

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Taghipour, Kathy. Mucosal disease. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0255.

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This chapter discusses the following mucous membrane disorders: pemphigus vulgaris, lichen planus, and Stevens–Johnson syndrome. Pemphigus vulgaris is an autoimmune disease that affects the skin and the mucosal membranes with blisters and erosions. Lichen planus is a cell-mediated immunological mucocutaneous disease; oral lichen planus may present with erosions, white streaks, or plaques in the oral cavity. Stevens–Johnson syndrome is an emergency dermatological condition in which an immunological hypersensitivity causes erosions and inflammation of mucosal membranes and the skin. As well as providing definitions of these diseases, this chapter discusses their etiology, typical symptoms, uncommon symptoms, demographics, natural history, complications, diagnostic approach, other diagnoses that should be considered, prognosis, and treatment.
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Dudhia, Sonal, Bhavin Dudhia, and Jigna Shah. Oral Lichen Planus: An Etiopathologic Study With Various Therapies. LAP Lambert Academic Publishing, 2013.

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Grover, Vishakha, Anoop Kapoor, and Poonam Sikri. Erosive oral lichen planus: Surgical therapy with bio-resorbable membrane. LAP Lambert Academic Publishing, 2012.

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Частини книг з теми "Oral lichen planu"

1

Herman, Bjorn, and Zoukaa B. Sargi. "Oral Lichen Planus." In Encyclopedia of Otolaryngology, Head and Neck Surgery, 1903–5. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-23499-6_66.

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van der Wal, Jacqueline E. "Oral Lichen Planus." In Encyclopedia of Pathology, 1–4. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-28845-1_736-1.

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3

McCullough, Michael J., Mohammad S. Alrashdan, and Nicola Cirillo. "Oral Lichen Planus." In Contemporary Oral Medicine, 1043–82. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-319-72303-7_14.

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McCullough, Michael J., Mohammad S. Alrashdan, and Nicola Cirillo. "Oral Lichen Planus." In Contemporary Oral Medicine, 1–40. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-28100-1_14-1.

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Nayee, Shalini, Cameron Herbert, and Jane F. Setterfield. "Oral Lichen Planus." In Diseases of the Oral Mucosa, 111–24. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-82804-2_11.

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van der Wal, Jacqueline E. "Oral Lichen Planus." In Encyclopedia of Soil Science, 290–93. Dordrecht: Springer Netherlands, 2016. http://dx.doi.org/10.1007/978-3-319-28085-1_736.

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Bragazzi, Nicola Luigi, and Claudio Nicolini. "Lichen Planus." In Genomics, Personalized Medicine and Oral Disease, 185–217. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-17942-1_9.

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8

Laeijendecker, R. "Orale lichen planus." In Praktijkboek tandheelkunde, 594–601. Houten: Bohn Stafleu van Loghum, 2008. http://dx.doi.org/10.1007/978-90-313-7318-5_47.

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9

Li, Yan, Kun Wang, Bo Zhang, Qichao Tu, Yufei Yao, Bomiao Cui, Biao Ren, et al. "Mycobiome Dysbiosis in Oral Lichen Planus." In Atlas of Oral Microbiology: From Healthy Microflora to Disease, 315–32. Singapore: Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-7899-1_9.

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De Carli, João Paulo, Soluete Oliveira da Silva, Bethânia Molin Giaretta De Carli, Angélica Zanata, Micheline Sandini Trentin, Maria Salete Sandini Linden, and Daniela Cristina Miyagaki. "Clinical Correlation of Oral Candidosis and Oral Lichen Planus." In Oral Candidosis, 75–82. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-662-47194-4_11.

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Тези доповідей конференцій з теми "Oral lichen planu"

1

Ganesha, Raziv, and Priyo Hadi. "Management of Oral Lichen Planus Due to Stress." In The 7th International Meeting and The 4th Joint Scientific Meeting in Dentistry. SCITEPRESS - Science and Technology Publications, 2017. http://dx.doi.org/10.5220/0007293601300134.

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2

Taranu, Tatiana, Magda Constantin, Didona Ungureanu, Irina Mihaela Esanu, and Mihaela Paula Toader. "IL6 is correlated with metabolic syndrome parameters in oral lichen planus." In 2015 E-Health and Bioengineering Conference (EHB). IEEE, 2015. http://dx.doi.org/10.1109/ehb.2015.7391410.

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Prasetyaningtyas, Neken, Ayu Fresno Argadianti, and Iwan Hernawan. "Management of Oral Lichen Planus Due to Stress In Post-Menopausal Women." In The 7th International Meeting and The 4th Joint Scientific Meeting in Dentistry. SCITEPRESS - Science and Technology Publications, 2017. http://dx.doi.org/10.5220/0007295302200226.

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4

Kistenev, Yury, Alexey Borisov, Alexander Shapovalov, Olga Baydik, and Maria Titarenko. "Diagnostics of oral lichen planus based on analysis of volatile organic compounds in saliva." In SPIE BiOS, edited by Valery V. Tuchin, Kirill V. Larin, Martin J. Leahy, and Ruikang K. Wang. SPIE, 2017. http://dx.doi.org/10.1117/12.2252131.

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Tabeti-Bentahar, CF, F. F Bouzouina, and F. F. Bénali. "Lichen plan buccal et transformation maligne : dix ans de suivi au Service de Pathologie et Chirurgie Buccales CHU Oran." In 62ème Congrès de la SFCO. Les Ulis, France: EDP Sciences, 2014. http://dx.doi.org/10.1051/sfco/20146203004.

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Звіти організацій з теми "Oral lichen planu"

1

Spirito, Francesca, Lorenzo Lo Muzio, and Mario Dioguardi. Oral lichen planus in children: systematic review. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, September 2022. http://dx.doi.org/10.37766/inplasy2022.9.0106.

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Ai, Huangping, Hang Yan, Lingfeng Li, Wenqing Jin, Chuncai Li, Zhao Jin, and Yuling Zuo. Efficacy of Traditional Chinese Medicine in Combination with Triamcinolone Acetonide in the Treatment of Erosive Oral Lichen Planus: A Systematic Review and Meta-Analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, January 2022. http://dx.doi.org/10.37766/inplasy2022.1.0101.

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