Дисертації з теми "Oral iron"
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Al-Refaie, Faris Nouraldin. "Oral iron chelation therapy with deferiprone (L(207))." Thesis, University College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.286321.
Повний текст джерелаDaba, Alina. "Insights on systemic and cellular iron homeostasis: hepcidin responses to oral and parenteral iron loading and an alternative mechanism for ferritin mRNA translation." Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=107735.
Повний текст джерелаLe fer est vital pour tous les organismes vivants, cependant étant donné son habilité à donner ou accepter des électrons facilement, il a aussi le potentiel d'être toxique. Des mécanismes très précis ont évolué pour contrôler l'homéostasie du fer aux niveaux systémique et cellulaire. L'hormone peptidique, hepcidine, contrôle l'homéostasie du fer au niveau systémique par la dégradation de la ferroportine, l'exportateur cellulaire du fer. En conséquence, l'efflux du fer des entérocytes, des macrophages et des hépatocytes vers la circulation diminue. Au niveau cellulaire, le système IRE / IRP contrôle, d'une manière coordonnée, les niveaux des protéines impliquées dans l'acquisition, l'utilisation, l'exportation et le stockage du fer. L'excès de fer est stocké dans la ferritine. Dans ce travail, nous examinons comment l'excès de fer est géré aux niveaux systémique et cellulaire. Dans le chapitre II, nous émettons l'hypothèse que les surcharges orale et parentérale en fer ont des effets différents sur l'homéostasie systémique du fer et sur l'expression de l'hepcidine chez les souris. Nous comparons les effets des surcharges orale et parentérale en fer aux niveaux circulatoire et tissulaire. Nous démontrons que la surcharge orale en fer excède la capacité hypoferrémique de l'hepcidine alors que la surcharge parentérale en fer induit une réponse retardée de l'hepcidine. Nous apportons aussi la preuve que la holo – transferrine circulatoire et le fer hépatocytaire sont les signaux uniques de l'activation ferrique de l'hepcidine. Dans le chapitre III, nous examinons comment l'excès de fer est géré au niveau cellulaire. Nous émettons l'hypothèse que la ferritine bénéficie d'un mécanisme alternatif de traduction, dépendant d'une séquence IRES. Nous inhibons l'initiation de la traduction dépendante de la coiffe 5' globalement, ou spécifiquement pour la ferritine, et traitons les cellules avec une source de fer. Nous démontrons que la ferritine surpasse le blocage global ou spécifique de la traduction dépendante de la coiffe 5'. Nous testons la présence d'une séquence IRES dans l'extrémité 5' de l'ARNm et par la suite nous la validons.
Whiteside, Douglas P. "Evaluation of the oral iron chelator deferiprone in the white leghorn chicken and domestic pigeon." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/NQ61990.pdf.
Повний текст джерелаHileti, Dona. "Biological and pharmacokinetic studies on the oral iron chelator 1, 2 dimethyl-3-hydroxpyrid-4-one." Thesis, University College London (University of London), 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.307678.
Повний текст джерелаLiebe-Harkort, Carola. "Oral disease and health patterns : dental and cranial paleopathology of the early Iron Age population at Smörkullen in Alvastra, Sweden /." Stockholm : Department of Archaeology and Classical Studies, Stockholm University, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-37301.
Повний текст джерелаEscorcio, Carla Solange de Melo. "AvaliaÃÃo do tratamento da anemia em pacientes com insuficiÃncia renal crÃnica em hemodiÃlise em uso de eritropoetina, ferro oral e endovenoso." Universidade Federal do CearÃ, 2005. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=322.
Повний текст джерелаO objetivo deste estudo foi avaliar comparativamente a evoluÃÃo do tratamento da anemia em pacientes com insuficiÃncia renal crÃnica (IRC), em hemodiÃlise, em uso de eritropoetina recombinante humana (EPO), tratados com ferro oral e ferro endovenoso em Fortaleza, CearÃ, no perÃodo de janeiro de 2004 a janeiro de 2005. Trata-se de um estudo transversal observacional descrito em duas clÃnicas de hemodiÃlise em Fortaleza, CearÃ. Os dados foram coletados a partir dos prontuÃrios e mapas de exame realizados mensalmente pelos pacientes. De 165 casos selecionados, apenas 89 (54%) compuseram o banco de dados da pesquisa. Deste total 65 (71%) pacientes estavam usando exclusivamente sulfato ferroso oral, 09 (10%) faziam uso exclusivo do sacarato de hidrÃxido de ferro III administrado por via endovenosa, e 18 (19%) faziam uso de ambos. Os parÃmetros analisados durante o estudo foram: idade, sexo, tempo de diÃlise, doenÃa de base, dosagem da hemoglobina, determinaÃÃo do hematÃcrito, dosagem sÃricas do ferro sÃrico, ferritina sÃrica, Ãndice de saturaÃÃo da transferrina, capacidade latente e total de ligaÃÃo do ferro. Analisando os parÃmetros hematolÃgicos conclui-se que a anemia encontra-se bem controlada e estabilizada. PorÃm, a maioria dos pacientes apresentou ferritina sÃrica <400ng/ml e Ãndice de saturaÃÃo da transferrina (IST) <20%. Constatou-se, que houve melhora da anemia nos pacientes com IRC em hemodiÃlse, tratados com EPO e ferro oral. Todavia, para otimizar o tratamento da anemia na IRC deve-se levar em consideraÃÃo as complicaÃÃes da doenÃa de base, o grau da anemia, os estoques de ferro e os efeitos adversos relacionados a ferroterapia.
The object of this study was to compare the effectiveness of polynuclear iron (III) hydroxide sucrose complex, administered intervenously, with iron sulfate in the treatment of anemia in 89 patients with chronic renal insufficiency in hemodialysis, with r-HuEPO, in Fortaleza from January 2004 to January 2005. It was a transversal prospective study conducted in two hemodialysis clinics in Fortaleza â Cearà .the data were collected from the patients medical charts and expressed as arithmetic mean + - SD. In accordance with treatment, the patients were grouped in terms of treatment :oral and intervenous iron, and intervenous iron. The following parameters were analyzed during the study: age, gender, length of dialysis , baseline, hemogloibin, hematocrit , serum iron , serum ferritin, saturation level of transferrina, latent capacity and bonding of iron. It was establish that there occurred no superior effectiveness with polynuclear iron (III) hydroxide sucrose complex, administered intervaneously, in the treatment of anemia in patients with IRC in hemodialysis, in the use of r-HuEPO. The analyzed parameters during the study verified indirectly the supply of iron. Consequently, it was not possible to establish a confident and precise determination of the deficiency or oversupply of iron in these patients.
Back, Danielsson Ing-Marie. "Masking Moments : The Transitions of Bodies and Beings in Late Iron Age Scandinavia." Doctoral thesis, Stockholm : Department of Archaeology and Classical Studies, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-6737.
Повний текст джерелаAndersson, Josefina. "Bildstenarna och den muntliga traditionen på Gotland under yngre järnålder." Thesis, University of Kalmar, School of Human Sciences, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:hik:diva-2122.
Повний текст джерелаAndersson, J. 2008. Bildstenarna och den muntliga traditionen på Gotland under yngre järnålder. The Picture Stones and the Oral Tradition of Gotland During the Late Iron Age. Högskolan i Kalmar ht 2008.
This is a study of the picture stones of Gotland and the oral tradition connected to them. This study consists of two main parts; in the main part the discussion focus on the oral tradition and the continuity of the same, where the memory plays a significant role. It also contains a discussion of the physical environment and its influences of the oral tradition. The second part concentrates around the picture stones, the variation of the scenes and the numerous of them.
Keywords: oral traditions, picture stones, late iron age, Gotland, Nordic mythology.
Omur-Ozbek, Pinar. "Macromolecular Reactions and Sensory Perception at the Air-Water-Human Interface." Diss., Virginia Tech, 2008. http://hdl.handle.net/10919/77226.
Повний текст джерелаPh. D.
Méndez, Francia Paola Alexandra, and Capcha Talia Lizbethy Misayauri. "Análisis de estudio de cohorte: factores asociados a la adherencia mensual a la suplementación oral de hierro en gestantes de Ayacucho y Andahuaylas entre 2006 y 2007." Bachelor's thesis, Universidad Peruana de Ciencias Aplicadas (UPC), 2021. http://hdl.handle.net/10757/655227.
Повний текст джерелаAnemia in pregnant women is a major public health problem worldwide. According to the registered prevalence, in Peru it persists as a moderate problem. Poor adherence to oral iron supplementation is one of the main barriers to the effectiveness of this intervention. The aim of this study was to determine the variation in adherence to oral iron supplements over time and the factors associated with it. To do this, the sentinel surveillance database of the "Study of Adherence to Iron Supplementation During Pregnancy in the Health Directions of Apurimac and Ayacucho", of general directorate of epidemiology (DGE), a longitudinal prospective cohort, was reanalyzed. A descriptive analysis of the 416 registered pregnant women and a bivariate and multivariate analysis based on 376 pregnant women was carried out. Sociodemographic, gestational, supplementation in the previous and current pregnancy variables were identified. For the analysis of the factors associated with adherence, the GEE model was used. At the second and third follow-up visit, adherence increased by 4% and 8%, while at the fifth and sixth, it decreased by 8% and 20,6%, respectively. The factors that reduced adherence were: dispensing failure (25,3%), nausea (9,5%), interaction of nausea and vomiting (13,5%), and did not like the supplement (11%). In conclusion, adherence decreases with time and the factors related to the supplement and the failure in the distribution are related to its reduction.
Tesis
Fernstål, Lotta. "Delar av en grav och glimtar av en tid : Om yngre romersk järnålder, Tuna i Badelunda i Västmanland och personen i grav X." Doctoral thesis, Stockholms universitet, Institutionen för arkeologi och antikens kultur, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-277.
Повний текст джерелаAuktoriserad namnform i LIBRIS: Fernstål, Charlotte, 1974-
Achtiani, Maliheh. "Le rôle éducatif des contes iraniens." Paris 5, 1994. http://www.theses.fr/1994PA05H104.
Повний текст джерелаOliaei, Shadi. "L'art du conteur en Iran : la récitation des histoires du "Sâh-nâme" dans les cafés traditionnels iraniens." Thesis, Montpellier 3, 2010. http://www.theses.fr/2010MON30025.
Повний текст джерелаThe art of naqqâli in Iran is based on a long tradition of epics involving heroes of the Iranian National legend. The main source of these epics, Ferdowsi’s Book of the Kings, is a cornerstone of the national culture. Over long hours, professional naqqâl recite passages from the Book of the Kings to the audience in tea-houses, known as traditional cafes. The naqqâli performance lasts about one and half hours and up to three parts for about half an hour each. A session usually begins with an introduction followed by a poetic prelude to outline the story and ends with the story itself. The beginning and end of each part are salavât (prayer recited in unison) and recitations of classic poems which are not necessarily related to the history itself, but in general serve the purpose of gaining the public attention during the performance. The quality of the naqqâl’s recitation based on a set of methods to give a larger dimension to the show such as: oratory techniques, gesture and musical approach. Naqqâl use parchment scroll called tumâr prepared for the performance which help with the recitation while taking liberties with respect to the text in order to attract the attention of their audience. The formal features of this type of performance which refer to its minimal constraints are : the fixed duration of performance and its serial form, the more or less direct influence of the structure of the tumâr, particularly its division into 3 levels of structural units : chapter, instalment and episode
ZHAO, BEI-MING, and 趙蓓敏. "The effects of oral iron supplementation on iron, zinc and copper status during pregnancy." Thesis, 1991. http://ndltd.ncl.edu.tw/handle/28370801745544228603.
Повний текст джерелаChang, Yu-Chien, and 張雨倩. "Preclinical study of oral iron chelator Deferasirox in combination with chemo-therapeutic drug in acute myeloid leukemia." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/27012354602367818085.
Повний текст джерела國立中興大學
生命科學系所
104
Iron catalyzes the formation of mutagenic reactive oxygen species (ROS), which are critically involved in the whole process of cancer formation including cancer cell initiation, proliferation, metabolism, angiogenesis and metastasis. Recent evidence suggests iron chelators may work as a potential anti-tumor agent through disturbing the iron metabolism. Actually, there is an interesting case report showing that the iron chalation therapy with deferasirox, intended to treat transfusional iron overload initially, induced complete remission on a patient of refractory and relapsed acute myeloid leukemia (AML). The anti-proliferation effects of various iron chelators were also demonstrated in many cancer cell lines, including neuroblastoma, cervical carcinoma, ovarian, and human leukemia. Nevertheless, the anti-leukemic activity and mechanism of iron chelators remained largely to be clarified. Our study is to examine the anti-leukemic activity and explore the potential anti-leukemic mechanism of the widely available oral iron chelator, the Deferasirox (DFX). Our results showed that low concentration of DFX (clinically achievable concentration) could effectively inhibit the growth of primary human AML cells as well as human AML cell lines (THP1 and HL60) and murine AML cell line (WEHI-3). DFX disturbs the cell cycle of THP1 cells by increasing the percentage of sub-G1 phase and decreasing the percentage of G2-M phase in a dose-dependent manner. We clearly showed that DFX induce caspase-3-related apoptosis and also inhibit ERK phosphorylation, which may account for the anti-leukemic effect of DFX. We also try to enhance the anti-leukemic effect through combination of DFX with the most commonly used chemotherapeutic agents for AML – the Doxorubicin (DOX) and Cytarabine (Ara-C). Interestingly, we found DFX may antagonize the anti-leukemic effect of DOX when DFX and DOX were added to the cell culture concomitantly. We found DFX markedly reduces the intracellular ROS generated by DOX, which may well explain the antagonistic effect between these two drugs. On the other hand, the concomitant use of DFX and Ara-C has a synergistic effect on AML cells. The ultimate goal of this study is to improve current AML treatment, especially elderly patients, which are frequently unable to tolerate intensive chemotherapy. We now plan to apply these viable information to design a clinical trial of using DFX and low-dose Ara-C for the treatment of elderly AML.
Li-XingYang and 楊理行. "The Mechanism of Iron-containing Nanoparticles Induced Selective Cytotoxicity in Oral Cancer Cells than Its Normal Counterpart." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/58789191778589760748.
Повний текст джерела國立成功大學
口腔醫學研究所
100
Oral squamous cell carcinoma is one of the top ten malignancies in many developing countries. According to Department of Health in Taiwan, oral cancer is ranked fourth leading cause of cancer death in male’s group. How to cure cancer while decrease the side effect and mortality is a big challenge to cancer therapy. In previous published study, we discovered that iron-core-gold-shell nanoparticles (Fe@Au NPs) have selective cytotoxicity in oral cancer cells (DOK, OECM1, SCC25, HCDB1, SCC9), but not in normal cells (hNOK, HUVEC, Vero, and gingiva fibroblast). In addition, Fe@Au NPs can cause mitochondria membrane potential lost and induce autophagy in OEC-M1. However, the mechanism of the selective cytotoxicity remains unsolved. In this study, we discovered that many iron-containing nanoparticles (FeAu alloy, Fe@Ag, Armor-Fe) also have the same selective cytotoxicity in OECM1. Furthermore, there is literature report that iron-platinum alloy (FePt) nanoparticles exhibit high cytotoxicity to ovarian cancer cell (A2780). These results suggest that iron element is a key factor in cytotoxicity effect. Base on this thinking, we identified through the Fe/O ratio analyzed by EDS that these iron-containing nanoparticles share one common characteristic, the non-oxidized iron, a possible key factor of the cytotoxicity. Otherwise, we also found that these iron-containing nanoparticles with high Fe/O ratio would induce severe ROS in cancer cells and caused irreversible mitochondria membrane potential lost. Furthermore, these iron-containing nanoparticles could also induce autophagy that caused autophagic cell death in cancer cells through the increased dose and time. In animal study, the iron-containing nanoparticles could inhibit tumor growth. In summary, we discover from this study that the non-oxidized iron of the iron-containing nanoparticles can function as a ROS inducer that can cause cancer cell death through autophagy. According to these findings, we hope to develop a new theranostic anti-cancer drug that can kill cancer cells more effectively and safely in the future.
Froessler, Bernd. "Pre-operative anaemia management with intravenous iron: a systematic review." Thesis, 2013. http://hdl.handle.net/2440/82606.
Повний текст джерелаThesis (M.Phil.) -- University of Adelaide, School of Translational Health Science, 2013
Almeida, Ricardo Sergio Couto de [Verfasser]. "The exploitation of host iron sources by Candida albicans during oral infection / von Ricardo Sergio Couto de Almeida." 2009. http://d-nb.info/992377471/34.
Повний текст джерелаOrozco, Monica. "In situ and in vivo modification by palm fruit-derived carotenes and tocotrienols on the oxidative response to commonly-prescribed doses of oral iron." 2008. http://hdl.handle.net/1993/21270.
Повний текст джерелаRemington, Matthew Spencer. "Fragile mechanics : connecting Holocaust and art education through the creation of a graphic novel." 2013. http://hdl.handle.net/2152/21235.
Повний текст джерелаtext
Furmanek, Joanna. "Wpływ mikrostruktury na przebieg przemiany izotermicznej oraz właściwości mechaniczne żeliwa ADI." Rozprawa doktorska, 2008. https://repolis.bg.polsl.pl/dlibra/docmetadata?showContent=true&id=5557.
Повний текст джерелаFurmanek, Joanna. "Wpływ mikrostruktury na przebieg przemiany izotermicznej oraz właściwości mechaniczne żeliwa ADI." Rozprawa doktorska, 2008. https://delibra.bg.polsl.pl/dlibra/docmetadata?showContent=true&id=5557.
Повний текст джерела