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G. Robayo, D. Adriana, Raquel F. Hernandez, Alveiro T. Erira, Ljubov Kandaurova, Celia L. Juarez, Victoria Juarez, and Angel Cid-Arregui. "Oral Microbiota Associated with Oral and Gastroenteric Cancer." Open Microbiology Journal 14, no. 1 (February 10, 2020): 1–17. http://dx.doi.org/10.2174/1874285802014010001.
Повний текст джерелаАнотація:
When the normal microbiota-host interactions are altered, the commensal microbial community evolves to a dysbiotic status resulting in some species becoming pathogenic and acting synergistically in the development of local and systemic diseases, including cancer. Advances in genetics, immunology and microbiology during the last years have made it possible to gather information on the oral and gastrointestinal microbiome and its interaction with the host, which has led to a better understanding of the interrelationship between microbiota and cancer. There is growing evidence in support for the role of some species in the development, progression and responses to treatment of various types of cancer. Accordingly, the number of studies investigating the association between oral microbiota and oral and gastrointestinal cancers has increased significantly during the last years. Here, we review the literature documenting associations of oral microbiota with oral and gastroenteric cancers.
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Savita Sharma. "Oral Cancer and HPV Connection: A Review." International Healthcare Research Journal 1, no. 8 (November 10, 2017): 240–42. http://dx.doi.org/10.26440/ihrj/01_08/122.
Повний текст джерелаАнотація:
HPV is the leading cause of oropharyngeal cancers and a few oral cavity cancers with increasing mortality across the globe. The risk factors for oral cancer are well known. Factors like tobacco chewing, smoking, alcohol consumption and actinic radiation have been extensively studied and clinically validated. However , Recently HPV has been shown to be a significant risk factor for oral and oropharyngeal cancers. The HPV family contains around 200 strains but it is important to note that only nine out of them are high risk and associated with cancers. Amongst them HPV16 is most strongly related with oral cancer. HPV associated cancers are different from cancers originating from other etiologies and thus , require a novel multidisciplinary treatment approach. The article is a review of Molecular Biology , Risk Factors ,Clinical aspects ,Diagnosis ,and Treatment of HPV associated Oral cancer .
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Soufi, Hissam E., Mohan Kameswaran, and Tarek Malatani. "Khat and oral cancer." Journal of Laryngology & Otology 105, no. 8 (August 1991): 643–45. http://dx.doi.org/10.1017/s0022215100116913.
Повний текст джерелаАнотація:
AbstractOral cancers in the Asir region of Saudi Arabia have been observed to occurmostly among patients who have been long-term khat users. In a survey that reviewed cancers for the past two years there were 28 head and neck cancer patients, 10 of whom presented with a history of having chewed khat. One of these was a case of metastatic cervical lymph node and unknown primary, one was a parotid tumour, and the remaining eight presented with oral cancers. All were non-smoking khat chewers and all of them had used itover a period of 25 years or longer. We conclude that this strong correlation between khat chewing and oral cancer warrants attention.
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Takano, Atsushi, Yoshihiro Yoshitake, Masanori Shinohara, Yohei Miyagi, and Yataro Daigo. "Characterization of URST1 as a prognostic biomarker and therapeutic target for lung and oral cancers." Journal of Clinical Oncology 35, no. 15_suppl (May 20, 2017): e14057-e14057. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.e14057.
Повний текст джерелаАнотація:
e14057 Background:Lung cancer and oral cavity cancer belong to aerodigestive cancers whose clinical outcome after multimodal therapy remains poor. Methods:To identify new biomarkers and therapeutic targets for lung and oral cancers, we screened genes using our original gene expression profile database for various solid cancers, and characterized clinical and oncogenic values of up-regulated in solid tumor 1 (URST1) protein as a candidate. Results: URST1 was highly expressed in the most of lung or oral cancer cell lines and tumor tissues, but was hardly detected in normal lung or oral epithelial cells and tissues as detected by real-time PCR and western blot analyses. Immunocytochemical analysis revealed that URST1 was mainly localized in the nucleus and cytoplasm of lung or oral cancer cell lines. Immunohistochemical analysis using tissue microarray showed that positive staining of URST1 was observed in 231 of 358 (64.5%) lung cancers, but not in normal lung, and it was significantly associated with poor prognosis after curative surgery. In addition, URST1 was expressed in 64 of 96 (66.7%) oral cancers, but not in oral mucosa, and it was significantly correlated with poor clinical outocome after surgery. Multivariate analysis confirmed that URST1 expression was an independent prognostic factor for oral cancer. Suppression of URST1 expression by siRNA or treatment with synthesized inhibitor specific for URST1 activity inhibited mitosis and growth of lung or oral cancer cell lines. Conclusions:URST1 is likely to be a prognostic biomarker and therapeutic target for aerodigestive cancers such as lung and oral cancers.
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Lim, Asher AT, Tze Haur Wee, and Raymond CW Wong. "Epidemiology of Oral Cancer Diagnosed at a Singapore Tertiary Healthcare Institution." Annals of the Academy of Medicine, Singapore 43, no. 2 (February 15, 2014): 96–101. http://dx.doi.org/10.47102/annals-acadmedsg.v43n2p96.
Повний текст джерелаАнотація:
Introduction: Oral and pharyngeal cancers grouped together are the sixth most common cancer seen worldwide. Oral cancers are, however, relatively not common in Singapore. There are few published epidemiological studies of oral cancers seen in Singapore. This article is a retrospective study of oral cancer incidence in a major tertiary institution in Singapore from 1991 to 2001. Materials and Methods: All oral cancers diagnosed from 1991 to 2001 were extracted from the register of histopathology results and case notes were reviewed. Results: In our study, it was found that oral malignancies preferentially affect older males. Chinese, being the predominant ethnicity, reports the highest incidence of oral malignancy. Squamous cell carcinoma was the most common oral malignancy with the tongue being the most commonly affected site. The majority of patients who sought treatment had complaints of swelling and were referred from restructured government hospitals and clinics. Conclusion: Dental professional should be aware of the common clinical presentation of oral cancers. As oral cancer is a disease of high morbidity and mortality, a concerted effort from the government and healthcare profession will be required to improve the outcome of the disease. Key words: Oral malignancies, Oral squamous cell carcinoma
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Bora, Panchali, Sanjeet Singh, Kanika Sharma, Nishant Singh, and Paramjit Singh. "ADVANCED DIAGNOSTIC AIDS IN ORAL PATHOLOGY." International Journal of Advanced Research 10, no. 08 (August 31, 2022): 511–17. http://dx.doi.org/10.21474/ijar01/15204.
Повний текст джерелаАнотація:
Oral cancers are one of the most common cancers worldwide today. They are usually neglected by the common population when compared to systemic cancers such as the lung cancer, colon cancer etc. However, they also may be extremely fatal if left untreated even at a very initial stage of the lesion. Early detection and treatment gives the best chance for its cure. The five-year survival rate of oral cancer still remains low and delayed diagnosis is suggested to be one of the major reasons. The detection and diagnosis are currently based on clinical examination, histopathological evaluation of the biopsy material and molecular methods. Several diagnostic aids have been developed over the years for early detection of oral cancer. The purpose of this article is to review the advanced available diagnostic adjuncts for the detection of oral cancer.
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Komma, Siva Teja, Anil Kumar Sakalecha, Mohiyuddin S. M. Azeem, A. V. Darshan, Rajeswari, and G. R. Varshitha. "Multi detector computed tomographic evaluation of neck spaces in locally advanced oral cancers." JOURNAL OF CLINICAL AND BIOMEDICAL SCIENCES 12, no. 1 (March 15, 2022): 22–29. http://dx.doi.org/10.58739/jcbs/v12i1.7.
Повний текст джерелаАнотація:
Background: Malignancy of the oral cavity account for about 7.6% of total cancer in India. Local anatomical spread of oral cancers into the face and maxilla and further extension into neck spaces is critical for staging of cancers. Cancer staging helps in the treatment of oral cancers. CT is considered the primary modality of investigation as it helps in delineating the size and extent of primary tumor. Objective: To perform multi-detector computed tomography (MDCT) and to evaluate its usefulness in as-sessing the involvement of deep neck spaces in locally advanced oral cancers. To assess CT morphology specifi-cally to know resectability or non-resectability of oral cancers. Methods and Material: Study included a total of 39 cases of locally advanced oral cancer referred for CECT neck. MDCT findings were analyzed with regard to location, size and extent of the disease and findings were correlated with either clinical follow up or surgical findings. Results: In our study highest number of cases were of carcinoma buccal mucosa (71.8 %) followed by carcinoma tongue and lower alveolus. Most commonly involved neck space was buccal space (94.9 %). CT was 100% accurate in detecting the bone erosion. Conclusion: MDCT evaluation of neck spaces in locally advanced oral cancers is a superior diagnostic tool in tumour staging and appropriate treatment planning. Surgical management of T4b oral cancers in our study subjects showed good results with > 50% of patients showing loco-regionally controlled disease after surgery. Keywords: Computed tomography, Neck spaces, Oral, Cancers
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Shinohara, Shogo, Masahiro Kikuchi, Hiroyuki Harada, Kiyomi Hamaguchi, Ryo Asato, Hisanobu Tamaki, Masanobu Mizuta, et al. "Clinicopathological Characteristics and Survival Outcomes of Patients with Buccal Squamous Cell Carcinoma: Results of a Multi-Institutional Study." Medicina 57, no. 12 (December 13, 2021): 1361. http://dx.doi.org/10.3390/medicina57121361.
Повний текст джерелаАнотація:
Background and Objectives: To investigate clinicopathological characteristics and survival outcomes of patients with buccal cancer in Japan. Materials and Methods: This study was conducted using a database of 1055 patients with oral cancers treated between 2010 and 2017 at 12 institutions in Japan. Ninety-two patients (8.7%) with primary buccal cancer were extracted and clinicopathological characteristics and survival outcomes were compared between patients with buccal cancers and patients with other oral cancers. Results: Ages were significantly higher in the patients with buccal cancer (73 years old vs. 69 years old). Buccal cancer had less advanced cT stage and cN stage than other oral cancers. Overall 5-year survival (OS) was 80.6%, and recurrence-free 5-year survival (RFS) of buccal cancers was 67.8%, and there were no significant differences in survival compared with other oral cancers in terms OS or RFS (5y-OS: 82.5%, 5y-RFS: 74.4%). However, patients with stage IV buccal cancer showed poorer prognosis in terms of OS and RFS compared with the same stage patients with other oral cancer. Advanced T stage was the only factor independently associated with both OS and RFS of patients with buccal cancer in this study. Conclusions: Postoperative radiotherapy or chemoradiotherapy should be considered to improve survival outcome of buccal cancer patients, especially for the patients with advanced primary site disease or a higher cancer stage.
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Reitano, Elisa, Nicola de’Angelis, Paschalis Gavriilidis, Federica Gaiani, Riccardo Memeo, Riccardo Inchingolo, Giorgio Bianchi, Gian Luigi de’Angelis, and Maria Clotilde Carra. "Oral Bacterial Microbiota in Digestive Cancer Patients: A Systematic Review." Microorganisms 9, no. 12 (December 14, 2021): 2585. http://dx.doi.org/10.3390/microorganisms9122585.
Повний текст джерелаАнотація:
The relation between the gut microbiota and human health is increasingly recognized. Recently, some evidence suggested that dysbiosis of the oral microbiota may be involved in the development of digestive cancers. A systematic review was conducted according to the PRISMA guidelines to investigate the association between the oral microbiota and digestive cancers. Several databases including Medline, Scopus, and Embase were searched by three independent reviewers, without date restriction. Over a total of 1654 records initially identified, 28 studies (2 prospective cohort studies and 26 case-controls) were selected. They investigated oral microbiota composition in patients with esophageal squamous cell carcinoma (n = 5), gastric cancer (n = 5), colorectal cancer (n = 9), liver carcinoma (n = 2), and pancreatic cancer (n = 7). In most of the studies, oral microbiota composition was found to be different between digestive cancer patients and controls. Particularly, oral microbiota dysbiosis and specific bacteria, such as Fusobacterium nucleatum and Porphyromonas gingivalis, appeared to be associated with colorectal cancers. Current evidence suggests that differences exist in oral microbiota composition between patients with and without digestive cancers. Further studies are required to investigate and validate oral–gut microbial transmission patterns and their role in digestive cancer carcinogenesis.
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Chaturvedi, Anil K., Neal D. Freedman, and Christian C. Abnet. "The Evolving Epidemiology of Oral Cavity and Oropharyngeal Cancers." Cancer Research 82, no. 16 (August 16, 2022): 2821–23. http://dx.doi.org/10.1158/0008-5472.can-22-2124.
Повний текст джерелаАнотація:
In 1988, Blot and colleagues reported results from a U.S. case–control study of oral cavity or pharyngeal (oropharyngeal and hypopharyngeal) cancers, with results showing independent associations of smoking and alcohol with increased risk, multiplicative interaction effects between smoking and alcohol, and that nearly three-quarters of these cancers are attributable to smoking and alcohol. The report by Blot and colleagues represents a landmark in oropharyngeal cancer epidemiology. This study, the largest at the time, introduced several novel concepts in oropharyngeal cancer epidemiology that remain relevant today—etiologic heterogeneity, statistical interaction effects, adjusted attributable fractions, and disparities by sex and race/ethnicity. Perhaps the most significant recognition in the field since 1988 is the etiologic association of human papillomavirus (HPV, primarily HPV16) with cancers arising in the oropharynx. Today, more than 80% of oropharyngeal cancers in the United States are caused by HPV while only approximately 3% of oral cavity cancers are caused by HPV. This etiologic heterogeneity across head and cancer subsites revealed by HPV is manifest at the genetic/genomic, epidemiologic, and clinical levels. Tobacco and alcohol remain the major etiologic factors for oral cavity cancers while HPV is the major cause of oropharyngeal cancers. Thus, tobacco and alcohol control and prophylactic HPV vaccination remain the most promising prevention tools for oral cavity and oropharyngeal cancers at this time. Importantly, the ever-emerging alternative tobacco products, such as smokeless tobacco/snus, hookah and water pipes, e-cigarettes, flavored cigars and cigarillos, and oral dissolvable products, represent a key public health concern and the carcinogenic effects of these products remains an active area of investigation. See related article by Blot and colleagues, Cancer Res 1988;48:3282–7
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Katiar, Vikas, Kumar Vineet, Amit Yadav, Ankita Kamthan, and Shubham Singh. "Malignant Bowel Obstruction due to Metastatic Carcinoma of Buccal Mucosa - A Case Report." Journal of Evidence Based Medicine and Healthcare 8, no. 23 (June 7, 2021): 1998–2000. http://dx.doi.org/10.18410/jebmh/2021/375.
Повний текст джерелаАнотація:
Cancers of the oral cavity are one of the most common malignancies encountered among cancer patients in India.1 There are different histological variants of oral cavity cancers, and squamous cell carcinoma (SCC) is most common among them. The main etiological factors implicated for development of oral cavity cancers are tobacco chewing and alcohol use.2 In India, carcinoma of buccal mucosa has the highest incidence among all the oral cavity cancers.3 The mean age of presentation is 50 years.4 Incidence among males is three times that of females.5 Most of the patients present in advanced stage (Stage III & IV) with majority in stage IV.6 Metastasis from oral cavity cancer takes place by detachment, invasion, proliferation and evasion through lymphatic system and blood vessels. It is regulated at various levels in the body.7 Most common sites of distant metastasis from oral cavity cancers are lungs and liver. Sometimes vertebral bone metastasis is also seen among patients. Metastasis to omentum and intra peritoneal organs other than liver is very rare.
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Chan, Man Hin, Feng Wang, Wai kong Mang, and Lap Ah Tse. "Sex Differences in Time Trends on Incidence Rates of Oropharyngeal and Oral Cavity Cancers in Hong Kong." Annals of Otology, Rhinology & Laryngology 127, no. 12 (September 29, 2018): 895–902. http://dx.doi.org/10.1177/0003489418802287.
Повний текст джерелаАнотація:
Objectives: Worldwide studies have shown an increasing trend of oropharyngeal squamous cell carcinoma (OPSCC) but a decreasing trend of oral cavity cancers over the past 2 decades, particularly in developed countries with successful tobacco control. This trend has been attributed to the increase in the incidence of human papillomavirus (HPV)–associated OPSCC. The aim of this study was to examine sex differences in incidence trends of oropharyngeal and oral cavity cancers in Hong Kong from 1983 to 2014. Methods: Using data from the Hong Kong Cancer Registry from 1983 to 2014, age-standardized incidence rates for potentially HPV-associated sites (oropharyngeal) and non-HPV-associated sites (oral cavity) were calculated, stratified by sex and age groups. Joinpoint regression and an age-period-cohort model were used to assess incidence trends. Results: A total of 1,972 cases of oropharyngeal cancer and 7,389 cases of oral cavity cancer were diagnosed from 1983 to 2014. The male/female ratios were 4.16:1 for oropharyngeal cancers and 1.63:1 for oral cavity cancers. A significant increasing trend was observed in oropharyngeal cancers from 1994 to 2014 (average annual percentage change = 2.66, P < .05). In contrast, a significant decreasing trend was observed in oral cavity cancers from 1983 to 1994 (average annual percentage change = −5.36, P < .05). The trends were more significant in men and in patients aged 45 to 69 years. A positive birth cohort effect was observed for oropharyngeal cancer in men. Conclusions: The rising trend of oropharyngeal cancer and decreasing trend of oral cavity cancer in Hong Kong from 1983 to 2014 are consistent with worldwide trends. Increase in high-risk sexual behaviors and oral HPV infection may influence the difference in trends.
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Kamer, A. R., L. Krebs, S. A. Hoghooghi, and C. Liebow. "Proliferative and Apoptotic Responses in Cancers With Special Reference To Oral Cancers." Critical Reviews in Oral Biology & Medicine 10, no. 1 (January 1999): 58–78. http://dx.doi.org/10.1177/10454411990100010301.
Повний текст джерелаАнотація:
The study of signal transduction pathways for mechanisms of apoptosis and proliferation has significantly advanced our understanding of human cancer, subsequently leading to more effective treatments. Discoveries of growth factors and oncogenes, especially those that function through phosphorylation on tyrosine residues, have greatly benefited our appreciation of the biology of cancer. The regulation of proliferation and apoptosis through phosphorylation via tyrosine kinases and phosphatases is discussed, as well as the contributions of other systems, such as serine and threonine kinases and phosphatases. Receptors with seven-transmembrane domains, steroid hormones, genes, and "death domains" will also be discussed. This review attempts to compare the regulation of the growth of normal tissues and cancers with an effort to highlight the current knowledge of these factors in the growth regulation of oral/oropharyngeal cancers. Despite the strides made in our understanding of growth regulation in human cancers, the study of oral/oropharyngeal cancer specifically lags behind. More research must be done to further our understanding of oral cancer biology, if we are to develop better, more effective treatment protocols.
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Arya, Supreeta, Devendra Chaukar, and Prathamesh Pai. "Imaging in oral cancers." Indian Journal of Radiology and Imaging 22, no. 3 (2012): 195. http://dx.doi.org/10.4103/0971-3026.107182.
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Ahmad, A. "Oral and Oropharyngeal Cancers." CA: A Cancer Journal for Clinicians 39, no. 6 (November 1, 1989): 397. http://dx.doi.org/10.3322/canjclin.39.6.397.
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Zanner, J. P. "Oral and Oropharyngeal Cancers." CA: A Cancer Journal for Clinicians 39, no. 6 (November 1, 1989): 398. http://dx.doi.org/10.3322/canjclin.39.6.398-a.
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Chowdhury, RiponMd. "Mitophagy and oral cancers." National Journal of Maxillofacial Surgery 13, no. 1 (2022): 11. http://dx.doi.org/10.4103/njms.njms_123_20.
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Bouquot, JE. "Oral cancers with leukoplakia." Oral Diseases 5, no. 3 (June 28, 2008): 183–84. http://dx.doi.org/10.1111/j.1601-0825.1999.tb00299.x.
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Shigematsu, Hisao, Keiichi Hosokawa, Masaaki Kaburagi, Akio Tanaka, Kaoru Kusama, and Hideaki Sakashita. "Multiple Primary Oral Cancers." Asian Journal of Oral and Maxillofacial Surgery 20, no. 2 (June 2008): 74–80. http://dx.doi.org/10.1016/s0915-6992(08)80014-3.
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Babu, K. Govind. "Oral cancers in India." Seminars in Oncology 28, no. 2 (April 2001): 169–73. http://dx.doi.org/10.1053/sonc.2001.21960.
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Dimitrov, Borislav D. "Epidemiology of oral cancers." Lancet Oncology 1, no. 3 (November 2000): 135. http://dx.doi.org/10.1016/s1470-2045(00)00049-8.
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D'Cruz, Anil K., Richa Vaish, and Harsh Dhar. "Oral cancers: Current status." Oral Oncology 87 (December 2018): 64–69. http://dx.doi.org/10.1016/j.oraloncology.2018.10.013.
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BABU, K. "Oral cancers in India." Seminars in Oncology 28, no. 2 (April 2001): 169–73. http://dx.doi.org/10.1016/s0093-7754(01)90088-0.
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Nayyar, AbhishekSingh, ManishaB Patil, T. Lavanya, CMeena Kumari, ShishirRam Shetty, Khalid Gufran, Vipin Viswanath, C. Swarnalatha, and JSuresh Babu. "Serum ceruloplasmin as cancer marker in oral pre-cancers and cancers." Journal of Carcinogenesis 20, no. 1 (2021): 15. http://dx.doi.org/10.4103/jcar.jcar_10_21.
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Hazarey, V., and A. Deshmukh. "Cancer-Free Drive in Rural India: Constituency Wise Initiatives by Member of Legislative Assembly." Journal of Global Oncology 4, Supplement 2 (October 1, 2018): 136s. http://dx.doi.org/10.1200/jgo.18.42500.
Повний текст джерелаАнотація:
Background and context: Reducing the rate of cancer through awareness and prevention programs as well improvements in screening and treatment techniques is paramount. Citizen especially in rural India tend to neglect health due to routine chores of family life. The nonavailability of facilities worsen the issue. Tobacco habits leads to potentially malignant disorders and oral cancers. There is increasing trend of breast cancer, uterine and cervical cancers and also oral cancers. In India oral cancers are main cancers in males. Member of legislative assembly is public representative to represent state of Maharashtra. Cancer Free Constituency Drive was for creating awareness and screening for villagers. Katol is a rural constituency. There are 288 constituencies in Maharashtra state. Aim: 1) To create public awareness of all types of cancers. 2) To provide diagnosis and investigations and treatment to affected population. 3) Capacity building of young medical and dental professionals in cancer diagnosis and paramedical workers in screening all types of cancers. Strategy/Tactics: 72,056 house visits by 220 Asha workers and 129 nursing students and 30 dental interns to sensitize about 3,00,000 people through well designed brochure for all cancers. Self-Mouth mirror examination was designed for oral cancers and awareness against tobacco. The persons with complaints were told to visit camps on scheduled dates at 10 primary health centers. Program/Policy process: The mammography facilities and Papanicolaou test examination, dental examination in mobile vans and self-mouth mirror examination for oral cancers with trained professional carried out diagnosis in 10 primary health centers with the help of experts in medical and dental professionals. Suspeced cases were referred to tertiary referral medical hospitals. Outcomes: 5100 (males 2216 and females 2954) with complaints visited. Total 813 patients suspected to have cancers were examined by specialists from gynecology(84) general surgery (374) otorhinolaryngology (77) pediatrics (37) dermatology (19) and dentistry (131). 38 abnormal on mammography in 132 females, 55 abnormal reports from Pap smears in 472 females were evaluated, however no cancer detected in three months span. Twelve cases of oral cancers were detected and treated. Six breast cancers were detected and treated. Seven other cancers were reported by medicine and pediatric specialists. 150 cases of potentially malignant disorders were also identified. 90 had the oral submucous fibrosis (inability to open the mouth) caused due to areca quid chewing. The self-mouth mirror examination helped to create awareness against tobacco. What was learned: Awareness of cancer leading to early detection and treatment is possible in rural areas through “Cancer-Free Constituency”. The concept will help to pave the way for improved strategies and policies to better control occurrence and treatment of cancer and to address tobacco related health disparities across cancer care continuum.
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Giuliano, Antonio. "Companion Animal Model in Translational Oncology; Feline Oral Squamous Cell Carcinoma and Canine Oral Melanoma." Biology 11, no. 1 (December 31, 2021): 54. http://dx.doi.org/10.3390/biology11010054.
Повний текст джерелаАнотація:
Companion animals with naturally occurring cancers can provide an advantageous model for cancer research and in particular anticancer drug development. Compared to commonly utilized mouse models, companion animals, specifically dogs and cats, share a closer phylogenetical distance, body size, and genome organization. Most importantly, pets develop spontaneous, rather than artificially induced, cancers. The incidence of cancer in people and companion animals is quite similar and cancer is the leading cause of death in dogs over 10 years of age. Many cancer types in dogs and cats have similar pathological, molecular, and clinical features to their human counterparts. Drug toxicity and response to anti-cancer treatment in dogs and cats are also similar to those in people. Companion animals share their lives with their owners, including the environmental and socioeconomic cancer-risk factors. In contrast to humans, pets have a shorter life span and cancer progression is often more rapid. Clinical trials in companion animals are cheaper and less time consuming compared to human trials. Dogs and cats with naturally occurring cancers are an ideal and unique model for human cancer research. Model selection for the specific type of cancer is of pivotal importance. Although companion animal models for translational research have been reviewed previously, this review will try to summarize the most important advantages and disadvantages of this model. Feline oral squamous cell carcinoma as a model for head and neck squamous cell carcinoma and canine oral melanoma as a model for mucosal melanoma and immunotherapy in people will be discussed as examples.
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Arora, Nitin, Jai Lal Davessar, and Jyoti Singh. "Oral cancer profile in a tertiary care center." International Journal of Otorhinolaryngology and Head and Neck Surgery 3, no. 2 (March 25, 2017): 343. http://dx.doi.org/10.18203/issn.2454-5929.ijohns20171191.
Повний текст джерелаАнотація:
<p class="abstract"><strong>Background:</strong> Head and neck cancers constitute around 5-50% of all cancers worldwide. <sup> </sup>Head and Neck Cancers constitute about 30% of all cancers that are found in India. It is the 8<sup>th</sup> most common cancer in the world. Oral cancer forms a major public health issue in India due to its rising incidence, especially in women and in younger age group. The purpose of our study was to evaluate, the epidemiologic profile of patients with oral cancer, its incidence according to age and sex, site distribution, risk factors involved and clinical stage at presentation.</p><p class="abstract"><strong>Methods:</strong> It is a prospective study done from January 2014 to November 2014, in a total of 100 patients in age group 21 to 70 years, irrespective of gender, with a proven malignancy confined to the oral cavity. Patients were observed for the age and sex distribution, tumour staging, location and<strong> </strong>metastasis, commonly associated risk factor and most common site. </p><p class="abstract"><strong>Results:</strong> Oral cavity cancers were more common in males, than females. It is most prevalent in age group of 51-60 years. Oral tongue is the most common site. Betel nut chewing is the most significant risk factor associated with oral cavity cancer.T1 and T2 is the most the most common primary T stage. Neck metastasis occurs most commonly at N2 stage. Most common neck node level involved is level 2.</p><p><strong>Conclusions:</strong> Oral cancers presents at advanced stage and age. It has also been seen in younger generations, which is due to increasing use of tobacco, its related products and alcohol. We see patient’s reports at advanced age and stage, which is increasing the<strong> </strong>morbidity and mortality related to oral cancers. Hence, today there is great need to create awareness about oral cancers. Preventive strategies must be designed in order to lessen the burden of Oral cancers. </p>
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Kerr, William C., and Yu Ye. "US Time Series Evidence regarding Alcohol-Related Risk of Oral Cancers and Protection against Stomach Cancers: Are Higher Concentration Beverages Different?" Contemporary Drug Problems 34, no. 3 (September 2007): 495–511. http://dx.doi.org/10.1177/009145090703400308.
Повний текст джерелаАнотація:
Autoregressive integrated moving average modeling procedures are utilized on population-level mortality rates for oral and stomach cancers in relation to per capita consumption of total alcohol, beer, wine, spirits and cigarettes to estimate long-term population-level relationships between alcohol consumption series and oral and stomach cancer mortality rates, and to determine whether higher-concentration alcoholic beverages, as represented by spirits, are more strongly related to these cancers than beer or wine. Total alcohol consumption is found to increase oral cancer rates by 3.5% per litre of ethanol. Spirits consumption is found to be the only significant predictor in multivariate models. For stomach cancers, total alcohol and especially spirits are found to be protective, with each litre of spirits associated with a 10% reduction in rates. High-concentration beverages, as represented by spirits, are found to be significant risk factors for oral cancers but potentially protective for stomach cancer.
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Tanaka, Takuji, Mayu Tanaka, and Takahiro Tanaka. "Oral Carcinogenesis and Oral Cancer Chemoprevention: A Review." Pathology Research International 2011 (May 22, 2011): 1–10. http://dx.doi.org/10.4061/2011/431246.
Повний текст джерелаАнотація:
Oral cancer is one of the major global threats to public health. The development of oral cancer is a tobacco-related multistep and multifocal process involving field cancerization and carcinogenesis. The rationale for molecular-targeted prevention of oral cancer is promising. Biomarkers of genomic instability, including aneuploidy and allelic imbalance, are possible to measure the cancer risk of oral premalignancies. Understanding of the biology of oral carcinogenesis will yield important advances for detecting high-risk patients, monitoring preventive interventions, and assessing cancer risk and pharmacogenomics. In addition, novel chemopreventive agents based on molecular mechanisms and targets against oral cancers will be derived from studies using appropriate animal carcinogenesis models. New approaches, such as molecular-targeted agents and agent combinations in high-risk oral individuals, are undoubtedly needed to reduce the devastating worldwide consequences of oral malignancy.
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Jewett, A., C. Head, and N. A. Cacalano. "Emerging Mechanisms of Immunosuppression in Oral Cancers." Journal of Dental Research 85, no. 12 (December 2006): 1061–73. http://dx.doi.org/10.1177/154405910608501201.
Повний текст джерелаАнотація:
Mounting effective anti-tumor immune responses against tumors by both the innate and adaptive immune effectors is important for the clearance of tumors. However, accumulated evidence indicates that immune responses that should otherwise suppress or eliminate transformed cells are themselves suppressed by the function of tumor cells in a variety of cancer patients, including those with oral cancers. Signaling abnormalities, spontaneous apoptosis, and reduced proliferation and function of circulating natural killer cells (NK), T-cells, dendritic cells (DC), and tumor-infiltrating lymphocytes (TILs) have been documented previously in oral cancer patients. Several mechanisms have been proposed for the functional deficiencies of tumor-associated immune cells in oral cancer patients. Both soluble factors and contact-mediated immunosuppression by the tumor cells have been implicated in the inhibition of immune cell function and the progression of tumors. More recently, elevated levels and function of key transcription factors in tumor cells, particularly NFκB and STAT3, have been shown to mediate immune suppression in the tumor microenvironment. This review will focus on these emerging mechanisms of immunosuppression in oral cancers.
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Murithi, Mary K., Teresa K. Ogeto, Michael N. Walekhwa, Richard K. Njunge, Micah K. Lagat, and Zablon L. Malago. "Oral contraceptives and intrauterine devices as risk factors for breast and cervical cancers: a systematic review." International Journal of Research in Medical Sciences 8, no. 6 (May 26, 2020): 2350. http://dx.doi.org/10.18203/2320-6012.ijrms20202294.
Повний текст джерелаАнотація:
Breast and cervical cancers have commandingly become major public health threats across the world. While studies have reported on the nexus between the use of oral contraceptives (OCs) and intrauterine devices (IUDs) as risk factors for breast and cervical cancers, there exists a paucity of explicit data on the nature of the association. Authors report the effect of oral contraceptives and the use of IUDs on the development of breast and cervical cancers. Several databases (Cochrane Library, Google Scholar and PubMed) were searched using well-specified criteria and a total of 15 papers selected. Meta-analyses, systematic reviews and studies that used cross-sectional designs were excluded from the review. Three and twelve cohort and case-control studies were reviewed respectively. Four of these studies reported an increased association between oral contraceptives and the risk of cervical cancer while nine showed positive correlation between oral contraceptives and risk of breast cancer. One study showed association between levonogestrel IUDs and risk of breast cancer while the other study did not show association between both levonogestrel and copper IUDs with risk of breast cancer. Use of copper IUDs was associated with diminishing risk of cervical cancer. Overall, use of oral contraceptives upsurges risk of breast and cervical cancers especially when used for longer periods of time. Further studies should therefore be done to understand the mechanisms of action of oral contraceptives and IUDs on the development of both cancers.
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Takano, Atsushi, Yoshihiro Yoshitake, Masanori Shinohara, and Yataro Daigo. "Characterization of OASEP1 as a biomarker and therapeutic target for oral cancer." Journal of Clinical Oncology 37, no. 15_suppl (May 20, 2019): e14627-e14627. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.e14627.
Повний текст джерелаАнотація:
e14627 Background: The improved understanding of cancer-specific oncoproteins could lead to the development of new biomarkers or therapeutic strategies for oral cancers. Methods: We conducted this study as follows: i) Identification of up-regulated genes in oral cancers by means of cDNA microarray, ii) Validation of clinicopathological significance of their protein expression by tissue microarray, iii) Examination of the growth on cancer cells by siRNA, iv) Elucidation of their biological effects on tumor growth. Results: We selected a secreted protein, OASEP1 (oral cancer-associated serum protein 1) as a candidate. Immunohistochemical staining showed that OASEP1 protein expression in cytoplasm was observed in 73 (74.4%) of 98 oral cancers that had undergone curative surgery. In addition, high level of OASEP1 expression was associated with poor prognosis for oral cancer patients ( P = 0.0158, by log-rank test). Suppression of OASEP1 expression by siRNA for OASEP1 significantly suppressed the growth of oral cancer cell lines partly through apoptosis as detected by flow cytometric analysis, apoptosis assays, and time lapse imaging. In addition, siRNAs for a candidate receptor of OASEP1 also significantly inhibited its expression and the growth of oral cancer cells, indicating that the functional interaction between OASEP1 and its receptor could regulate the growth of oral cancer cells. Conclusions: Our data suggest that OASEP1 is a possible prognostic biomarker and therapeutic target for oral cancer.
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Gerson, Stanley J. "Oral Cancer." Critical Reviews in Oral Biology & Medicine 1, no. 3 (July 1990): 153–66. http://dx.doi.org/10.1177/10454411900010030101.
Повний текст джерелаАнотація:
In the U.S. oral cancer accounts for 2.1% of all cancers and 1% of cancer deaths. Two to three times as many males as females are affected. Blacks have more intra-oral cancer than whites, and their incidence and mortality rates have increased in recent years. The etiologic process very likely involves several factors. The major etiologic agents are tobacco (all types) and alcoholic beverages. Herpes simplex virus, human papilloma virus, and Candida have been implicated. Host factors include poor state of dentition, nutritional aberrations, cirrhosis of liver, lichen planus, and immunologic impairmant. Cellular changes include amplification of some oncogenes, alterations in antigen expression, production of gamma-glutamyl transpeptidase, and disturbance of keratin and involucrin production. Experimentally, cancer is readily produced on the hamster cheek pouch and rat oral mucosa. Unlike oral cancer in humans, most experimental lesions are exophytic, and they rarely metastasize.
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Narasimhan, N. Sangeetha, and N. Malathi Narasimhan. "The Emerging Role of Micro RNA21 in Oral Cancer." Biomedical and Pharmacology Journal 11, no. 4 (December 25, 2018): 1961–66. http://dx.doi.org/10.13005/bpj/1569.
Повний текст джерелаАнотація:
Oral cancer is one among the leading causes of death in developing countries of south Asia. A very high incidence of oral cancer in India has resulted due to the prevalence of tobacco use both in smokable and Chewable forms. Though molecular level changes that occur in the initiation and progression of oral cancer has been studied, the disease process is still poorly understood unlike other cancers. MicroRNAs are the trending name in cancer research. They are non-coding RNAs that control the genome by their complementarity and affect protein synthesis. Their role in various cancers have been well studied. This paper enlightens the role of MicroRNA21 in oral cancer.
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Kedar, Ashwini, Roopa Hariprasad, Vipin Kumar, Kavitha Dhanasekaran, and Ravi Mehrotra. "Association of metabolic NCD risk factors with oral, breast and cervical precancers and cancers in India." Family Medicine and Community Health 7, no. 4 (October 2019): e000180. http://dx.doi.org/10.1136/fmch-2019-000180.
Повний текст джерелаАнотація:
ObjectiveTo find an association between metabolic non-communicable disease (NCD) risk factors (high blood pressure (BP), high random blood sugar (RBS) and overweight /obesity) and oral, breast, cervical cancers/precancerous or potentially malignant conditions.DesignThis is an observational study using convenience sampling. The participants were screened through opportunistic or population-based screening.SettingThe study was conducted at a health promotion clinic (HPC) located in Northern India under the Indian Council of Medical Research. HPC is a screening clinic where screening is done for hypertension (HT), diabetes mellitus (DM), obesity, and oral, breast and cervical cancers. The study was conducted between December 2016 and January 2019.ParticipantThe number of participants screened was 8352 (6712 women and 1640 men). All consenting men and women above 18 years were included. All participants were screened for oral cancer, DM, HT and obesity. All women were also screened for breast and cervical cancers. Cervical screening was done for non-pregnant women 21 years and above with history of sexual activity.ResultOral potentially malignant disease (OPMD) was the most prevalent, followed by breast cancer, oral cancer, cervical cancer and cervical precancer. High RBS had a strong association with oral cancer (OR=2.29, 95% CI 1.09 to 4.82, p=0.03) and breast cancer (OR=1.95, 95% CI 1.01 to 3.76, p=0.05). High BP had a strong association with breast cancer (OR=2.50, 95% CI 1.43 to 4.35, p<0.0001). An inverse association was noted between oral cancer and overweight/obesity (OR=0.20, 95% CI 0.08 to 0.48, p<0.0001). Current tobacco use was strongly associated with oral cancer (OR=6.51, 95% CI 3.63 to 11.67, p<0.0001) and OPMD (OR=9.82, 95% CI 8.13 to 11.86, p<0.0001). No association was elicited between the metabolic NCD risk factors and cervical cancer/precancer.ConclusionsThe study reaffirms that NCD metabolic risk factors determine oral and breast cancers. Besides NCD risk factors, current tobacco use was a strong determinant of OPMD and oral cancer. Hence, primary and primordial prevention measures to control NCD metabolic risk factors and tobacco use should move along with secondary prevention of breast and oral cancers.
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Vilen, Suvi-Tuuli, Tuula Salo, Timo Sorsa, and Pia Nyberg. "Fluctuating Roles of Matrix Metalloproteinase-9 in Oral Squamous Cell Carcinoma." Scientific World Journal 2013 (2013): 1–11. http://dx.doi.org/10.1155/2013/920595.
Повний текст джерелаАнотація:
One hallmark of cancer is the degradation of the extracellular matrix (ECM), which is caused by proteinases. In oral cancers, matrix metalloproteinases (MMPs), especially MMP-9, are associated with this degradation. MMPs break down the ECM allowing cancer to spread; they also release various factors from their cryptic sites, including cytokines. These factors modulate cell behavior and enhance cancer progression by regulating angiogenesis, migration, proliferation, and invasion. The development of early metastases is typical for oral cancer, and increased MMP-9 expression is associated with a poor disease prognosis. However, many studies fail to relate MMP-9 expression with metastasis formation. Contrary to earlier models, recent studies show that MMP-9 plays a protective role in oral cancers. Therefore, the role of MMP-9 is complicated and may fluctuate throughout the different types and stages of oral cancers.
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Khan, Mohammad Sayedur Rahman, Fatama Siddika, Sun Xu, Xiao Lin Liu, Mei Shuang, and Hao Fu Liang. "Diagnosing oral squamous cell carcinoma using salivary biomarkers." Bangabandhu Sheikh Mujib Medical University Journal 11, no. 1 (March 4, 2018): 1. http://dx.doi.org/10.3329/bsmmuj.v11i1.35399.
Повний текст джерелаАнотація:
<p class="Abstract">Oral cancer is becoming frightful public health issue because of its raising incidence as well as mortality rates worldwide. Out of all types of oral cancer, the oral squamous cell carcinoma is the most common malignant tumor with an incidence of about 90%. This fatal disease is diagnosed through a comprehensive clinical examination followed by the histological assessments forming the diagnostic gold standard. Although the oral cavity is simply accessible, but maximum oral cancers are usually diagnosed at the late stage. Consequently, it is necessary to implicate newer screening and early diagnosing approaches which will diminish the morbidity as well as mortality related to this disease. Saliva which is a complex biological fluid has a direct relation with the oral cancer lesion and contains abnormal DNA, RNA, protein molecules released by the malignant cells. These can be labelled as neoplastic biomarkers proposed to play an important role in diagnostic, therapeutic and prognostic purposes for oral cancers as well as other diseases. The aim of this review paper is to concisely discuss the different types of potential salivary biomarkers as well as their interaction for screening of oral cancers.</p>
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Dendy, Richard A. "Oral cancer." Morecambe Bay Medical Journal 1, no. 8 (May 1, 1992): 206–8. http://dx.doi.org/10.48037/mbmj.v1i8.1179.
Повний текст джерелаАнотація:
Cancers of the oral cavity and surrounding structures constitute approximately 3% of malignancies in the Lancaster area, the majority of which are squamous cell carcinomas. Although they are relatively uncommon, they can be very distressing to patients and relatives alike. It is important to note that a proportion of squamous cell carcinomas are preceded by visible premalignant lesions, and these can be eliminated. In addition, early cancers are more easily treated.
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Panneerselvam, Karthika, Shigeo Ishikawa, Rajkumar Krishnan, and Masahiro Sugimoto. "Salivary Metabolomics for Oral Cancer Detection: A Narrative Review." Metabolites 12, no. 5 (May 12, 2022): 436. http://dx.doi.org/10.3390/metabo12050436.
Повний текст джерелаАнотація:
The development of low- or non-invasive screening tests for cancer is crucial for early detection. Saliva is an ideal biofluid containing informative components for monitoring oral and systemic diseases. Metabolomics has frequently been used to identify and quantify numerous metabolites in saliva samples, serving as novel biomarkers associated with various conditions, including cancers. This review summarizes the recent applications of salivary metabolomics in biomarker discovery in oral cancers. We discussed the prevalence, epidemiologic characteristics, and risk factors of oral cancers, as well as the currently available screening programs, in India and Japan. These data imply that the development of biomarkers by itself is inadequate in cancer detection. The use of current diagnostic methods and new technologies is necessary for efficient salivary metabolomics analysis. We also discuss the gap between biomarker discovery and nationwide screening for the early detection of oral cancer and its prevention.
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Thobias, Ashi Robert, Kinjal Ankit Patel, Supreet Dhananjay Bhatt, Kruti Ashvinkumar Mehta, Chetana Deepal Parekh, Pariseema Sharad Dave, and Prabhudas Shankarbhai Patel. "Human papillomavirus: footprints in the population of western India." Epidemiology and Health 43 (February 3, 2021): e2021013. http://dx.doi.org/10.4178/epih.e2021013.
Повний текст джерелаАнотація:
OBJECTIVES: Cancer is a multi-factorial disease, with various intrinsic and environmental factors contributing to its occurrence. Human papillomavirus (HPV) has been associated with the occurrence of many cancers. India severely suffers from 3 HPV-associated cancers (cervical cancer, oral cancer, and oropharyngeal cancer). Hence, the present study aimed to evaluate the HPV burden in these 3 cancers among patients from the western region of India.METHODS: DNA was isolated from samples from 400 cervical cancer, 127 oral cancer, and 75 oropharyngeal cancer patients. Polymerase chain reaction was performed using degenerate primers for HPV infection.RESULTS: Overall, HPV infection was observed in 87% of cervical cancer cases, 12.5% of oral cancer cases, and 26.7% of oropharyngeal cancer cases when analyzed with a cumulative detection method using the MY 09/11, GP 5+/6+, and CP I/II primer sets.CONCLUSIONS: A significant prevalence of HPV infection was detected in all 3 cancers using the degenerate primer sets. This finding implies that testing for HPV infection using multiple primer sets is crucial for determining its actual prevalence in various malignancies.
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Grulich, Andrew E., Fengyi Jin, E. Lynne Conway, Alicia N. Stein, and Jane Hocking. "Cancers attributable to human papillomavirus infection." Sexual Health 7, no. 3 (2010): 244. http://dx.doi.org/10.1071/sh10020.
Повний текст джерелаАнотація:
Although the human papillomavirus (HPV) vaccine was introduced primarily as a cervical cancer prevention vaccine, HPV has a causal role in several types of cancer. This article reviews the epidemiological evidence for the role of HPV in human cancer, and describes Australian trends in these cancers. HPV is a necessary cause of cervical cancer. The currently vaccine-preventable subtypes of HPV 16 and 18 are responsible for ~70% of cervical cancer. The introduction of an organised Pap smear program in Australia led to a steep decline in incidence over the past decades. HPV can be detected in ~40% and 70% of vulval and vaginal cancers respectively. Rates of these cancers have been stable over the past 20 years. The prevalence of HPV in penile cancer is ~50% and incidence has not recently changed. For anal cancer, ~85% of cases are HPV positive, and incidence has increased significantly in both men and women over the past 20 years. In the oral cavity, ~35% of oropharyngeal cancers and ~25% of other oral cavity cancers are HPV positive. The incidence of HPV-related oral cavity and oropharyngeal cancers is increasing, whereas incidence at HPV-unrelated sites is decreasing. Overall, 1154 HPV-related cancer cases were potentially preventable by vaccination. If HPV-related cancers at non-cervical sites are prevented by vaccination, then a similar number of cancer cases will be prevented as in the cervix. However, almost one-quarter of the potentially preventable cancer cases are in men, who are not included in the current national immunisation program.
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Coon, Jeffrey, and Karl Kingsley. "Assessment of MicroRNA (miR)-365 Effects on Oral Squamous Carcinoma Cell Line Phenotypes." Biomolecules 11, no. 6 (June 12, 2021): 874. http://dx.doi.org/10.3390/biom11060874.
Повний текст джерелаАнотація:
miR-365 is a microRNA that regulates transcription and has been demonstrated to promote oncogenesis and metastasis in some cancers while suppressing these effects in others. Virtually no information is known about the presence or function of miR-365 in oral cancers. Based upon this information, the primary goal of this project was to evaluate the expression of miR-365 in existing oral cancer cell lines. Five commercially available oral cancer cell lines (SCC4, SCC9, SCC15, SCC25, and CAL27) were obtained and cultured. RNA was then screened by PCR using primers specific for miR-365, as well as matrix metalloproteinase (MMP-2) and a downstream cancer stem cell regulator (NKX2.1), and structural and metabolic standards (beta actin, GAPDH). miR-365 was detected among these oral cancers, and some cells also expressed NKX2.1 and MMP-2, which correlated with miR-365 levels. The relative expression of miR-365, NKX2.1, and MMP-2 RNA was higher than expected. Transfection of miR-365 resulted in a significant increase in proliferation, which was not observed in the negative controls. These data appear to confirm miR-365 expression in oral cancers, which may also be correlated with MMP-2 and NKX2.1 expression. Moreover, the fastest growing oral cancers with the highest viability produced the most miR-365. In addition, miR-365 transfected into cells significantly increased growth, even in normal cells. More research is needed to elucidate the pathways responsible for these observations.
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Khan, Yasmin, Avani Verma, Anila Varghese, and Sidharth Sekhar Mishra. "The compelling necessity for improvement in cancer screening in India in this decade." Indian Journal of Community Health 34, no. 4 (December 31, 2022): 577–78. http://dx.doi.org/10.47203/ijch.2022.v34i04.024.
Повний текст джерелаАнотація:
In 2020, cancers of the breast, lip and oral cavity and cervix were the three most common cancers in India.(1) The national programme for prevention and control of cancer, diabetes, cardiovascular diseases and stroke (NPCDCS) recommends a population-based screening for identifying pre-cancerous lesions and early detection of these three cancers by front line health workers.(2) Data about cancer screening has been included in the latest National Family Health Survey (NFHS-5).(3) We have tried to understand the current status of cervical, breast and oral cancer screening in India.
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Hounkpatin, Spéro H. Raoul, Fatiou Alabi Bouraima, Marius Claude Flatin, Marie-Claire Balle, and Luc Valere C. Brun. "Epidemiological profile of oral cancers in Benin." International Journal of Otorhinolaryngology and Head and Neck Surgery 6, no. 2 (January 24, 2020): 234. http://dx.doi.org/10.18203/issn.2454-5929.ijohns20200134.
Повний текст джерелаАнотація:
<p class="abstract"><strong>Background:</strong> The objective of the study was to study the epidemiological profile of malignant tumours of the oral cavity in Benin from January 2009 to 31 December 2014.</p><p class="abstract"><strong>Methods:</strong> This was a descriptive cross-sectional study that examined cancers of the oral cavity collected in the registers of the 5 anatomy and pathology laboratories in Benin as well as the only hospital in the country that sends its requests for histological examinations abroad. </p><p class="abstract"><strong>Results:</strong> With a rate of 19.8%, oral cavity cancer was the most frequent cancer localization in the ENT, head and neck sphere in Benin. The most frequent sites of cancers in the oral cavity were the palate (32.2%) followed by the tongue (25.4%) and the inner face of the cheeks (16.9%). The average age of the patients was 53.18±20.60 years with extremes of 1 year and 90 years. The sex ratio was 0.90. Squamous cell carcinoma was the most common histological type with 67.80%.</p><p class="abstract"><strong>Conclusions:</strong> Cancer of the oral cavity must be a priority for health authorities in Benin. Research must be initiated to determine the factors that contribute to it.</p>
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Gupta, Pankaj. "An update on light-based technologies and fluorescent imaging in oral cancer detection." Oncobiology and Targets 04 (2017): 1. http://dx.doi.org/10.18639/onbt.2017.04.511587.
Повний текст джерелаАнотація:
Oral cancer is a potentially fatal disease that constitutes an important portion of tumors of head and neck region. More than 90% of oral cancers are oral squamous cell carcinomas (OSCC). Regardless of the fact that the oral cavity is easily accessible to the accumulation of carcinogens, most oral cancers are typically detected at an advanced stage leading to lower survival rate among subjects. Therefore, early detection of the oral cancer and its precursor lesions may be the most effective means to improve prognosis and treatment in most patients. One of the emerging technologies is the use of optical methods to capture the molecular changes at high-resolution to improve the detection capability of early stage disease. Optical diagnosis techniques when compared with traditional approaches such as vital staining, biopsy has many advantages such as objectivity, speed, and cost. Moreover, these incorporate particularly noninvasive methods of oral cancer detection. The present article highlights various optical methods and their role in oral cancer detection.
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Kurasawa, Yasuhiro, Akihiko Iida, Kaya Narimatsu, Hideki Sekiya, Yutaka Maruoka, and Yukihiro Michiwaki. "Effects of Perioperative Oral Management in Patients with Cancer." Journal of Clinical Medicine 11, no. 21 (November 6, 2022): 6576. http://dx.doi.org/10.3390/jcm11216576.
Повний текст джерелаАнотація:
Perioperative oral management (POM) is used to prevent pneumonia in patients with cancer. However, the factors that expose hospitalized patients to increased risk of developing pneumonia remain unclear. For example, no study to date has compared the incidence of pneumonia in hospitalized patients by cancer primary lesion, or POM implementation, or not. We determined which patients were most likely to benefit from POM and examined the effects of POM on pneumonia prevention and mortality. In a total of 9441 patients with cancer who underwent surgery during hospitalization, there were 8208 patients in the No POM group, and 1233 in the POM group. We examined between-group differences in the incidence of pneumonia and associated outcomes during hospitalization. There was no significant between-group difference in the incidence of pneumonitis, however, patients with lung, or head and neck cancers, demonstrated a lower incidence of postoperative pneumonia. Among patients with lung and pancreatic cancers, mortality was significantly lower in the POM group. POM appears effective at reducing the risk of postoperative pneumonia in patients with certain cancers. Further, mortality was significantly lower in patients with lung and pancreatic cancers who received POM; hence, POM may be an effective adjuvant therapy for patients with cancer.
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Chan, Wei-Jen, Han-Lin Cho, Venkanagouda Goudar, Sasinan Bupphathong, Chi-Hung Shu, Chi Kung, and Fan-Gang Tseng. "Boron-enriched polyvinyl-alcohol/boric-acid nanoparticles for boron neutron capture therapy." Nanomedicine 16, no. 6 (March 2021): 441–52. http://dx.doi.org/10.2217/nnm-2020-0401.
Повний текст джерелаАнотація:
Background: Due to the noninvasive nature of boron neutron capture therapy (BNCT), it is considered a promising cancer treatment method. Aim: To investigate whether polyvinyl alcohol/boric acid crosslinked nanoparticles (PVA/BA NPs) are an efficient delivery system for BNCT. Materials & methods: PVA/BA NPs were synthesized and cocultured with brain and oral cancers cells for BNCT. Results: PVA/BA NPs had a boron-loading capacity of 7.83 ± 1.75 w/w%. They accumulated in brain and oral cancers cells at least threefold more than in fibroblasts and macrophages. The IC50 values of the brain and oral cancers cells were at least ninefold and sixfold lower than those of fibroblasts and macrophages, respectively. Conclusion: Theoretically, PVA/BA NPs target brain and oral cancers cells and could offer improved therapeutic outcomes of BNCT.
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Coelho, Ken Russell. "Challenges of the Oral Cancer Burden in India." Journal of Cancer Epidemiology 2012 (2012): 1–17. http://dx.doi.org/10.1155/2012/701932.
Повний текст джерелаАнотація:
Oral cancer ranks in the top three of all cancers in India, which accounts for over thirty per cent of all cancers reported in the country and oral cancer control is quickly becoming a global health priority. This paper provides a synopsis of the incidence of oral cancer in India by focusing on its measurement in cancer registries across the country. Based on the International Classification of Disease case definition adopted by the World Health Organisation, and the International Agency for Research on Cancer, this review systematically examines primary and secondary data where the incidence or prevalence of oral cancer is known to be directly reported. Variability in age-adjusted incidence with crude incidence is projected to increase by 2030. Challenges focus on measurement of disease incidence and disease-specific risk behavior, predominantly, alcohol, and tobacco use. Future research should be aimed at improving quality of data for early detection and prevention of oral cancer.
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Chen, Ping-Ho, Chia-Min Chung, Yen-Yun Wang, Hurng-Wern Huang, Bin Huang, Ka-Wo Lee, Shyng-Shiou Yuan, Che-Wei Wu, Lee-Shuan Lin, and Leong-Perng Chan. "CYP26A1 Is a Novel Biomarker for Betel Quid-Related Oral and Pharyngeal Cancers." Diagnostics 10, no. 11 (November 21, 2020): 982. http://dx.doi.org/10.3390/diagnostics10110982.
Повний текст джерелаАнотація:
Betel quid (BQ) has been classified as a Group I human carcinogen in light of evidence demonstrating an association with an elevated risk of oral and pharyngeal cancers. To date, the incidence rate of oral and pharynx cancers among Taiwanese men ranks the highest worldwide. However, no study has yet confirmed variants of CYP26A1 was associated with the risks of oral and pharyngeal cancers. A case-control study was conducted (n = 339). CYP26A1 polymorphism was performed using SNP assay. Real-time qRT-PCR and Western blotting were used to determine the levels of CYP26A1 expression. The cancer cell model involved treatment with arecoline. Our findings showed that the downregulation of CYP26A1 mRNA and protein expression are more frequently observed in cancerous tissues than adjacent normal tissues in patients with oral and pharynx cancers (p < 0.01). We found that CYP26A1 was downregulated as the arecoline dose increased. We hypothesized that lower levels of CYP26A1 mRNA expression can be utilized a clinically biomarker causes oral and pharynx cancers. Arecoline appears to modulate CYP26A1 expression through specific pathways. Carriers of CYP26A1 SNP, rs2068888 (G/G)/rs4418728 (G/G) and who have lower levels of CYP26A1 expression are associated with an increased risk of oral and pharyngeal cancers.
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Agrawal, Swati, Vrinda Saxena, Swapnil Jain, Vijayta Sharva, Shibani Sarangi, and Chandrahas Thakur. "Early detection and prevention of oral cancer: an appraisal." International Journal Of Community Medicine And Public Health 7, no. 1 (December 25, 2019): 367. http://dx.doi.org/10.18203/2394-6040.ijcmph20195883.
Повний текст джерелаАнотація:
Oral cancers (OC) represent the majority of head and neck cancers with more than half million patients being affected each year worldwide. Oral squamous cell carcinoma is the sixth commonest cancer worldwide, accounting for approximately 4% of all cancers. Therefore, an improvement in the prevention and control of oral cancer is of critical importance. This may be achieved by reducing the risk through avoidance of tobacco and alcohol, recognizing and treating premalignant lesions and detecting developed OC at an early stage. Data search for the present review was done electronically. Electronic search was conducted using databases such as Pubmed and Medline, Cochrane library, articles published in peer-reviewed journals, text books, grey literature and from sites of World Health Organization, Centre For Diseases Control Report, Global Adult Tobacco Survey and Global Youth Tobacco Survey reports. This review ruled out web of causation and web of prevention including early detection and prevention to be an ideal strategy to reduce the prevalence of oral cancer and its impact on quality of life. Screening and early detection in population at risk have been proposed to decrease both morbidity and mortality associated with the oral cancer.