Статті в журналах з теми "Optimized guar gum solution preparation"
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1
Khan, S., S. Rustagi, A. Kumari, and A. Singh. "Optimization of the recipe for composite flour-based sugar-free biscuits." Food Research 7, no. 2 (March 8, 2023): 11–18. http://dx.doi.org/10.26656/fr.2017.7(2).982.
Повний текст джерелаАнотація:
Biscuits are widely consumed bakery products around the globe. Its excess consumption has led to many health problems such as diabetes, obesity, and cardiovascular diseases. Although sugar replacement may be a step in solving most health-related issues, the complication is in its formulation. It is tedious to replace sugar and prepare biscuits with quality attributes, including aeration, texture, and mouthfeel. The present study aimed to formulate composite flour-based sugar-free biscuits. A composite flour, millet-legumebased mixture, was used for biscuit preparation. The central composite design of response surface methodology (RSM) (Design Expert 11 version) was used to analyse the effect of eliminating sugar using polydextrose (A) (10-15%) and guar-gum (B) (0-1.5%) at different levels on physical (thickness and spread ratio) and textural (hardness and fracturability) attributes. The optimized biscuit was prepared, and the precision of the optimized biscuit was determined using a one-sample T-test in SPSS Statistics version 22. The optimization with the design expert resulted in the best solution, i.e., polydextrose (12.488%) and guar-gum (0.921%) with the highest desirability value of 0.993. The ANOVA, R2 , and R2 adjusted values for thickness, spread ratio, hardness and fracturability showed that the formulated sugar-free biscuits were statistically significant. Sugar elimination from the control biscuits noticeably affects its physical and textural attributes. Biscuits prepared were of lesser diameter, spread ratio, comparable hardness and fracturability than control biscuits, mainly due to the composite flour used in the formulation of experimental biscuits. The protein present in the flour restricts the spread of sugar-free biscuits because of its higher binding capacity. However, the addition of polydextrose and guar-gum resulted in the preparation of accepted quality sugar-free biscuits. To conclude, the proposed sugar-free biscuits may be a solution to the presen
2
Su, Ying, Yi Ding Shen, Xiao Juan Lai, and Xiao Rong Wang. "Preparation and Property of Hydrophobic Modified Guar Gum Thickener." Advanced Materials Research 631-632 (January 2013): 260–64. http://dx.doi.org/10.4028/www.scientific.net/amr.631-632.260.
Повний текст джерелаАнотація:
The modified guar gum was synthesized with guar gum as material and bromododecane as etherifying agent by suspension polymerization method. The solution and gel of the modified guar gum were also prepared. The structure and the property of the modified guar gum were analysized by Fourier transform infrared spectrum (FT-IR), X-ray diffraction (XRD) and thermogravimetric analysis (TGA). The heat resistance and the viscoelasticity modulus of the gel were also researched by rheometer. The results of FT-IR and XRD show that the hydrophobic long chain has been introduced into the guar gum successfully. TGA indicates that the modified guar gum has higher thermal stability. The rheology tests reflect that with different temperature conditions, the shear viscosity, the viscoelasticity modulus of the gel and the heat resistance of the modified guar gum are both better than that of the unmodified guar gum. The modified guar gum can be used as thickener of fracturing fluid, and it can reduce its amount.
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Chen, Feng, Xu Guang Wang, and Ren Shu Yang. "Preparation of Low Molecular Weight Guar Gum for Fracturing by Enzymatic Degradation." Advanced Materials Research 971-973 (June 2014): 127–30. http://dx.doi.org/10.4028/www.scientific.net/amr.971-973.127.
Повний текст джерелаАнотація:
Guar gum was subjected to degradation in high concentration aqueous solution by enzymatic treating to obtain high concentration low molecular weight guar gum for fracturing. The study indicates that the high concentration guar gum aqueous solution can be degraded effectively by enzymatic treating. The enzymatic treating conditions were investigated and the optical enzymatic treating pH, temperature and enzyme add amount are respectively 6, 50°C and 0.1g/L, and various of low molecular weight guar gum with different molecular weight can be obtained by controlling the enzymatic treating time.
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Xiong, Yun, Xu Zhang, and Ming Zhu Liu. "Surface-Crosslinked Guar Gum-g-Sodium Polyacrylate Superabsorbents: Swelling Characteristics and Mechanics Performance." Applied Mechanics and Materials 729 (January 2015): 39–46. http://dx.doi.org/10.4028/www.scientific.net/amm.729.39.
Повний текст джерелаАнотація:
Guar gum grafted sodium polyacrylate have been prepared via aqueous solution graft polymerization. Furthermore, the polymers were then surface-crosslinked using trimethylolpropane triglycidyl ether (TMPTGE) to improve the properties of swollen hydrogel. Polymerization conditions were systematically optimized to achieve the optimum swelling capacity. FTIR and DSC spectra confirmed that sodium acrylate had been grafted onto guar gum chains. SEM observations showed morphology of the samples. The results confirmed that introducing guar gum into the superabsorbent could improve the swollen hydrogel mechanics performance, including hydrogel strength, resilience and dispersion, although making the water absorbency decreasing slightly. The good mechanics performance will make it feasible in hygiene application.
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Wang, Jin, Bingbing Bai, Yan Wei, Qingchen Wang, Qiang Deng, Tingting Kong, Chengtun Qu, and Ying Tang. "Catalytic Oxidation of Polymers Remained in Oilfield by Transition Metal-Ethylenediamine Complex." Journal of Biobased Materials and Bioenergy 16, no. 5 (October 1, 2022): 765–69. http://dx.doi.org/10.1166/jbmb.2022.2233.
Повний текст джерелаАнотація:
This work is intended to seek for an efficient Fe-based Fenton reagent for clean oxidation of waste fracturing fluid containing hydroxypropyl guar gum (HGG) and other polymers in wide pH range. A series of complex was prepared with transition metal and ethylenediamine (L) by the coordination. The catalytic performance of the complexes were evaluated in the degradation of HGG, and the reaction conditions were optimized. The kinetics of HGG degradation was evaluated by means of the chemical oxygen demand (COD) and the viscosity. The results show that Fe(II)L exhibits high catalytic performance for the degradation of hydroxypropyl guar gum in a wide pH range of 7.0–11.0, the COD removal can reach to 86.4%. Under the optimum experimental conditions, the relative viscosity of hydroxypropyl guar gum solution can be reduced effectively to 7.99 from 247 with 10.0% H2O2 in presence of 5.0% Fe(II)L. Besides, under the optimized condition, three typical polymers used in oilfield can be degradated effectively.
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Gaur, Anchal. "Preparation and Evaluation of anti-viral drug Zanamivir using different polymers." YMER Digital 21, no. 07 (July 29, 2022): 1240–47. http://dx.doi.org/10.37896/ymer21.07/a3.
Повний текст джерелаАнотація:
The dosage forms that stay in the stomach for longer period of time are much more effective to treat any disease. Thus, most approachable and feasible way is to prolong the drug delivery and controlling gastric residence time (GRT) and such kind of dosage forms are known as gastro retentive dosage forms (GRDF). The present study is focused to develop GRDF of Zanamivir. About four formulations of Zanamivir tablets were prepared with different ratios of drug and polymers. The prepared tablets were further evaluated on the basis of precompression and post-compression parameters. The dissolution study of the formulations revealed that formulation F3 using polymer (guar gum) showed 93.4% of in vitro drug release for 8 hours and is the optimized formulation. It was thus concluded that guar gum complies all the properties of floating tablets. Keywords: Zanamivir, Dissolution, Gastro retentive drug delivery system, First pass elimination, Influenza, Prophylaxis
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Wang, Lili, Xiancheng Wang, Yifeng Shen, Jianzhong Shao, and Fuyu Pei. "Synthesis and properties of s-triazine di-sulfanilic guar gum as a thickener in reactive printing." Textile Research Journal 88, no. 15 (May 15, 2017): 1766–75. http://dx.doi.org/10.1177/0040517517708541.
Повний текст джерелаАнотація:
S-triazine di-sulfanilic guar gum (TSG) was successfully prepared by monochlorotriazine di-sulfanilic (TS) and guar gum (GG) in order to improve the printing properties in reactive printing. The results showed that the optimized synthesis condition of TSG was at sodium carbonate solution 1.2 g/L at 90℃ for 75 min through the single-factor experiment. Compared to GG, TSG had better flowability, mainly viscous effects and higher viscosity recoverability, which was more appropriate as a thickener in reactive printing. In the cotton printing experiment, TSG had higher paste add-on, color yield, penetration and levelness than GG. Furthermore, the printing effects of TSG on cotton drew near to those of sodium alginate, which could obtain evenly colored large patterns and excellent outline sharpness.
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J. Meena, S. K. Verma, R. Rameshwari, and D. K. Verma. "POLYANILINE/CARBOXYMETHYL GUAR GUM NANOCOMPOSITES: AS BIODEGRADABLE, CONDUCTIVE FILM." RASAYAN Journal of Chemistry 15, no. 02 (2022): 1021–27. http://dx.doi.org/10.31788/rjc.2022.1526820.
Повний текст джерелаАнотація:
Biomaterial-based nanocomposites have been increased in demand in industries for a purpose of packaging and sensing because of their low cost and environmentally friendly nature. But less work has been done on conductive, biodegradable film preparations. This article is devoted to the preparation of Polyaniline/ Carboxymethyl guar gum nanocomposites film and their applications. Controlled synthesis of polyaniline in the presence of carboxymethyl guar gum solution has been carried out for the synthesis of these nanocomposites. Then nanocomposite films have been obtained by solution casting method in one step. The object of this research work was to prepare a conductive, biodegradable, flexible film. Such made nanocomposites film has been further tested for FTIR, SEM, UTM, Conductivity, Swelling behavior and biodegradability. The results have been concluded that by this method a fine flexible, conductive, biodegradable film may be prepared that can be applied in different fields for further study.
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Sai, S. M., R. P. Swain, and A. K. Mahapatra. "PREPARATION AND IN VITRO EVALUATION OF BIODEGRADABLE ZIDOVUDINE LOADED CONTROLLED RELEASE MICROSPHERES USING NATURAL GUMS AS RELEASE RETARDANTS." INDIAN DRUGS 56, no. 06 (June 28, 2019): 37–45. http://dx.doi.org/10.53879/id.56.06.11667.
Повний текст джерелаАнотація:
The objective of the present investigation was to evaluate the entrapment efficiency of the anti-HIV drug, zidovudine, using natural gums and study the zidovudine release. Zidovudine-loaded microspheres were prepared by external ionotropic gelation technique. Sodium alginate in combination with guar gum or xanthan gums in different ratios were used. The microspheres of different core: coat ratios were formulated and evaluated for entrapment efficiency, particle size, percentage yield, swelling index, in vitro drug release and kinetic studies. Drug polymer compatibility studies were performed by Fourier Transform Infrared (FTIR) spectroscopy. The formulation was characterized by X-ray powder diffraction (XRD) and scanning electron Microscope (SEM). The zidovudine loaded microspheres have a particle diameter ranging approximately 450-779 μm. The FTIR showed compatibility between drug and excipients. Processing parameters (stirring speed, concentration of cross linking agent, volume of the processing medium on drug entrapment efficiency were optimized. F20 (1 g of sodium alginate and 0.150 g of guar gum) and F13 (1 g of sodium alginate, 0.250 g of xanthan gum) formulations showed better release (ANOVA, ˂0.05) profiles over a period of 12 h. Natural gums are biodegradable, safe, non-toxic and are used as release retardants and these can be extended to prepare microspheres of other drugs.
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Sugita, Purwantiningsih, Bambang Srijanto, Budi Arifin, and Ellin Vina Setyowati. "STABILITY OF KETOPROFEN COATED BY CHITOSAN-GUAR GUM GEL." Indonesian Journal of Chemistry 9, no. 3 (June 24, 2010): 391–97. http://dx.doi.org/10.22146/ijc.21504.
Повний текст джерелаАнотація:
The coating stability of ketoprofen by chitosan-guar gum gel has been studied. Into 228.6 mL of 1.75% (w/v) chitosan solution in 1% (v/v) acetic acid, 38.1 mL of guar gum (gg) solution was added with concentration variation of 0.35, 0.55, and 0.75% (w/v) for ketoprofen microcapsules, and stirred with magnetic stirrer until homogenous. Afterwards, 7.62 mL of glutaraldehyde (glu) was added slowly under stirring, with concentrations varied: 3, 3.5, and 4% (v/v). All mixtures were shaked for 20 min for homogenization. Into each microcapsule mixture for ketoprofen, a solution of 2 g of ketoprofen in 250 mL of 96% ethanol was added. Every mixture was then added with 5 mL of 2% Tween-80 and stirred with magnetic stirrer for an hour at room temperature. Conversion of suspension into fine powders/granules (microcapsules) was done by using spray dryer. Every microcapsule formula was packed into capsules, as much as 100 g per capsule. The capsules were contained in 100-mL dark bottles and the bottles were kept in climatic chamber at (40 ± 2) °C and RH (75 ± 5) % for 3 months. The microcapsule stabilities were tested chemically and physically. The result showed that formulation of ketoprofen preparation composed of 1.75% (w/v) chitosan, 0.35% (w/v) gg, and 3.50% (v/v) glu, was relatively the best, with ketoprofen percentage left in microcapsule after 3 months, degradation rate constant, and shelf life of 80.33%, 0.0351 % week-1, and 18.92 months, respectively. Reaction kinetic model for this formula followed Prout-Tompkins equation and the degradation of ketoprofen was seem to follow autocatalytic reaction mechanism controlled by the formation and growth of reaction core. Keywords: Ketoprofen, chitosan-guar gum gel
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Aman, Junaid, Navin Chandra Shahi, Umesh Chandra Lohani, Divya Balodhi, Rajat Singh, Naveen Kumar, Mohd Ishfaq Bhat, and Avvaru Praveen Kumar. "Process Optimization for Development of Guar Gum-Based Biodegradable Hydrogel Film Using Response Surface Methodology." Bioinorganic Chemistry and Applications 2022 (August 16, 2022): 1–13. http://dx.doi.org/10.1155/2022/9180000.
Повний текст джерелаАнотація:
In the current study, a guar-gum-based biodegradable hydrogel film was prepared using an initiator (potassium persulfate), crosslinker (N-N methyl bis acrylamide), and plasticizer (glycerol) for packaging of fruits and vegetables. The effect of independent variables (initiator, crosslinker, and plasticizer) on the biodegradation (% wt. loss), color difference (ΔE), hardness (N), swelling index (%), and transparency (%) of the film was studied using Box–Behnken design, random surface methodology (RSM). The results showed significant effects on all the abovementioned parameters, and it was observed that the developed model was accurate, with a prediction error of only −3.19 to 2.99%. The optimized formulation for the preparation of hydrogel film was 0.15% initiator, 0.02% crosslinker, and 2.88% plasticizer exhibiting satisfactory biodegradability, color difference, hardness, swelling index, and transparency. Results showed that a guar-gum-based biodegradable hydrogel film has adequate physical, optical, and biodegradable properties and can be successfully utilized in the food packaging industry.
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Lakshmi, P. K., D. Lavanya, and M. M. Husnien Ali. "Effect of synthetic super disintegrants and natural polymers in the preparation of donepezil hydrochloride fast disintegration films." International Current Pharmaceutical Journal 3, no. 3 (February 5, 2014): 243–46. http://dx.doi.org/10.3329/icpj.v3i3.17892.
Повний текст джерелаАнотація:
The main aim of the present research was to develop a fast dissolving oral polymeric film with good mechanical properties, faster disintegration and dissolution when placed on tongue. Donepezil hydrochloride (DPH) is prescribed in the treatment of mild to moderate Alzheimers disease (AD). The polymers selected for preparing films were sodium alginate (SA), poly vinyl alcohol (PVA) and guar gum (GG). Three batches of films were prepared by solvent casting method with sodium alginate, sodium alginate & PVA and with the combination of sodium alginate & guar gum. From these three batches, three optimized film formulations S3, SP7 and SG8 were selected based on disintegration time. To these three selected film formulations, superdisintegrants sodium starch glycolate (SSG), cross carmellose sodium (CCS) and cross povidone (CP) were added at a concentration of 4% w/w of polymer to improve the disintegration time. The films prepared with or without superdisintegrants were compared for fast releasing properties. Based on DT and in vitro dissolution data, S3CP was selected as the best formulation among the all formulations.DOI: http://dx.doi.org/10.3329/icpj.v3i3.17892 International Current Pharmaceutical Journal, February 2014, 3(3): 243-246
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Khan, Sheeba, Shivani Rustagi, and Avinash Singh. "Optimization of composite flour-based sugarfree muffins." emergent Life Sciences Research 08, no. 02 (2022): 31–40. http://dx.doi.org/10.31783/elsr.2022.823140.
Повний текст джерелаАнотація:
Muffins are among high sucrose-containing bakery products enjoyed globally for their soft texture and great taste. Its excess consumption results in high-calorie intake, leading to many health problems such as diabetes, obesity, cardiovascular disorders, etc. Replacement of sucrose from muffins helps in the preparation of low-calorie bakery products. The objective of the current study was the preparation of sugar-free muffins and examining their effect on the height and textural attributes. Refined flour was replaced with millet-legume-based composite flour selected from our previous work. Statistical analysis was done using the central composite design of Design Expert, v.11. Polydextrose and guar-gum were the variables, and height, hardness, fracturability, springiness, adhesiveness, cohesiveness, and resilience were the responses in the experimental design. The ANOVA, R2, and R2 adjusted values for all the responses except cohesiveness and resilience showed a significant effect of polydextrose and guar-gum on the height and textural quality of sugarfree muffin. Replacement of sucrose resulted in muffins with lower height (p ˂0.01), more hardness, more fracturability, lesser springiness, adhesiveness (p˂0.05), and no significant effect on cohesiveness and resilience. Incorporating composite flour containing high fiber and protein in the muffin formulation may be another reason for the present findings. However, adding polydextrose and guar-gum to sugar-free muffins has helped to prepare low-calorie products with accepted quality attributes. The best solution from optimization with a design expert was polydextrose (12.627%) and guar-gum (0.707%) with a desirability value of 0.791. These sugar-free muffins will help the bakery industry achieve the new goal of preparing less energy-containing functional foods. In the future, this research will help food technologists and bakery experts to prepare sugar-free muffins with desirable quality
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Wang, Wen Bo, and Ai Qin Wang. "Preparation, Swelling and Water-Retention Properties of Crosslinked Superabsorbent Hydrogels Based on Guar Gum." Advanced Materials Research 96 (January 2010): 177–82. http://dx.doi.org/10.4028/www.scientific.net/amr.96.177.
Повний текст джерелаАнотація:
Utilization of natural polymer as matrix for preparing hydrogels can improve the performance of the materials and render them environmentally friendly. In this work, the guar gum-g-poly(sodium acrylate) (GG-g-PNaA) superabsorbent hydrogels were prepared by the solution graft copolymerization of natural guar gum (GG) with partially neutralized acrylic acid (NaA) using ammonium persulfate (APS) as initiator and N,N′-methylenebisacrylamide (MBA) as crosslinker. FTIR spectra confirmed that NaA had been grafted on GG chains. The effects of reaction variables including the concentration of APS and MBA, the weight ratio of acrylic acid (AA) to GG and the neutralization degree of AA on water absorption were investigated. The superabsorbent hydrogel prepared under optimal condition gives the best absorption of 1107 g∙g–1 in distilled water and 88 g∙g–1 in 0.9 wt% NaCl solution. Effects of external pH on the swelling properties of hydrogels were investigated, and the practical water retention properties of the hydrogels were also evaluated. Results indicated that the hydrogels exhibited excellent pH-stability in a wide pH range from 4 to 11, and the water-retention capabilities of sand soils were also greatly improved after utilizing the superabsorbent hydrogels. This superabsorbent hydrogels could be used as potential eco-friendly water-saving materials for agricultural or ecological application.
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Parashar, Tarun, and Nardev Singh. "FORMULATION AND IN VITRO EVALUATION OF BILAYER TABLET OF ATENOLOL FOR BIPHASIC DRUG RELEASE." Asian Journal of Pharmaceutical and Clinical Research 11, no. 5 (May 1, 2018): 114. http://dx.doi.org/10.22159/ajpcr.2018.v11i5.22975.
Повний текст джерелаАнотація:
Objective: In the present research work, the aim was to prepare the bilayer tablet of atenolol for biphasic drug release to improve its bioavailability and absorption in the lower gastrointestinal tract. Methods: In the formulation of immediate release crospovidone, croscarmellose sodium, and sodium starch glycolate was used as super disintegrate and was directly compressed. For a sustained release portion different grade hydroxypropyl methylcellulose (HPMC) K4M, HPMC K15M, gum tragacanth, gum acacia, guar gum, and ethyl cellulose. Preformulation studies were performed before compression. The compressed bilayer tablets were evaluated for weight variation, dimension, hardness, friability, drug content, disintegration time, and in vitro drug release using USP dissolution apparatus type 2 (paddle). Results: The formulation IR3 showed 95% drug release in 30 min, and regression coefficient value (r2) value was found to be 0.994 suggesting first-order drug release kinetics. The F9 formulation using HPMC K15M and gum acacia (1:1) showed 91.20% drug release at the end of 12 h, and regression coefficient value (r2) was 0.992 suggesting zero-order drug release kinetics. Formulation IR3F9 showed faster drug release for bilayer tablet containing 5%w/w crospovidone in immediate release layer and HPMC and guar gum (1:1) in sustained release. Formulation IR3F9 showed swelling index 206%, floating lag time was found to be 2 min and total floating time up to 12 h. Conclusion: The formulation IR3F9 showed a faster drug release profile among the others in the preparation of the atenolol bilayer tablet. Hence, it was considered as an optimized formulation.
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Naseem, Faiza, Shefaat Ullah Shah, Sheikh Abdur Rashid, Arshad Farid, Mazen Almehmadi, and Saad Alghamdi. "Metronidazole Based Floating Bioadhesive Drug Delivery System for Potential Eradication of H. pylori: Preparation and In Vitro Characterization." Polymers 14, no. 3 (January 27, 2022): 519. http://dx.doi.org/10.3390/polym14030519.
Повний текст джерелаАнотація:
Metronidazole has the potential to produce local stomach specific action in order to treat Helicobacter pylori induced peptic ulcer disease. The current project executes the development of osmotically controlled bioadhesive metronidazole loaded effervescent floating tablets with optimized floating and swelling behavior. Direct compression technique was used to prepare the tablets. The designed formulations exhibited physico-chemical properties within acceptable optimum limits as per pharmacopeial requirements. The results of tablet floating studies revealed that all formulations, except F1 and F5, had good buoyancy characteristics (TFT > 12 h except F2 and F8 with TFT of 6 h). Formulation F2 containing guar gum in higher concentration with carbopol and formulation F8 containing guar gum in 50% decreased concentration in combination with HPMC and carbopol had enhanced FLT appreciably, with least TFT as compared to formulations F3, F4, and F6 (ANOVA; p ≤ 0.05). Formulation batches of F3, F4, and F6 exhibited appreciable FLT as well as TFT and were optimized formulations. Out of the above mentioned optimized batches, F4 and F6 formulations showed low FLT (4 and 5 s respectively). The results of the swelling study indicated a proportionate increase in the swelling index with increase in time. A significantly higher swelling ratio was found with formulation F6 and F4 compared with that of F7 and F8 (ANOVA; p ≤ 0.05). Additionally, the impact of pH change, agitational intensity, as well as increasing concentration of NaCl was investigated on drug release. It was observed that agitational intensity had no effect on drug release rate while increasing concentration of NaCl produced an increased drug release from the dosage form as compared to the drug release exhibited by the formulations in the absence of NaCl. Overall, this project could have valuable contribution in the fabrication of metronidazole loaded effervescent floating tablets. Gastro-retentive systems are expected to enhance local stomach specific action of anti H. pylori agents based on their buoyancy and swelling behavior.
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Zhang, Wen, Xuening Ren, Lele Zhang, and Jianghu Chen. "Preparation and Performance of Thickened Liquids for Patients with Konjac Glucomannan-Mediated Dysphagia." Molecules 27, no. 7 (March 28, 2022): 2194. http://dx.doi.org/10.3390/molecules27072194.
Повний текст джерелаАнотація:
The present study sought to characterize the rheological and thickening properties of Konjac glucomannan (KGM) and prepare thickening components for special medical purposes using KGM and maltodextrin as the primary raw materials and guar gum (GG), xanthan gum (XG), locust bean gum (LBG), and carrageenan (KC) as the supplemented materials. The formulation and preparation processes were optimized through single factor experiments taking sensory evaluation as an indicator. The results confirm that KGM had excellent thickening performance, reaching about 90 times its own mass. The optimal formulation process of the thickening components based on KGM was as follows: the mass concentration of the compound thickener (KGM/GG/XG/LBG/KC = 13:2:2:2:1) was 5.0–7.0 mg/mL; the maltodextrin concentration was 10.0 mg/mL; the brewing temperature of the thickening component was 60 °C with no restriction on consumption time. The rheology test results revealed that the thickening components had shear thinning characteristics, which could provide three different thickening effects of nectar-thick level (350 mPa·s), honey-thick level (1250 mPa·s), and pudding-thick level (1810 mPa·s) suitable for people with different degrees of chewing disorders. Overall, this study provides a theoretical basis and technical reference for KGM as a dietary nutrition support for patients with dysphagia.
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Rani, T. Neelima. "Formulation Development and Optimization of Oral Thin Films of Zolpidem Tartarate." Medical Science & Healthcare Practice 1, no. 1 (April 6, 2017): 26. http://dx.doi.org/10.22158/mshp.v1n1p26.
Повний текст джерелаАнотація:
<em>The aim of the present study was to formulate and evaluate oral thin films of zolpidem tartarate. Zolpidem tartarateis used to treat insomnia. It affects chemicals in your brain that may become unbalanced and cause sleep problems (insomnia). Zolpidem tartarate oral thin films were prepared by using solvent casting method. In this method, water soluble polymer is completely dissolved in to form uniform clear viscous solution other ingredients including API are dissolved in a small portion of aqueous solvent by using a high shear processor. This viscous solution is degassed under the vacuum to remove the air bubbles. This bubble free solution is poured into a glass mold and kept in oven at 40 º-50ºC. Oral disintegrating films are prepared using three grades of polymers HPMC E5, GUAR GUM and SODIUM ALGINATE Compatibility of Zolpidem tartarate with polymers was confirmed by FT-IR studies. All the formulations were evaluated for their physical appearance, average weight and thickness, folding endurance, disintegration time, tensile strength, percentage elongation, drug content, content uniformity and in vitro drug dissolution studies. From the result, it was concluded that the fast dissolving films of Zolpidem tartarate can be made by solvent casting technique with enhanced dissolution rate and taste masking by using suitable combination of sweeteners, flavors and citric acid. The final composition optimized was drug to Guar Gum ratio of 1:1, plasticizer concentration of 15% w/w of polymer. The film had acceptable physical properties, assay and uniformity values and in vitro dissolution within 2 minutes.</em>
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Rangari, Nalanda Tulsiram, and Prashant K. Puranik. "DEVELOPMENT OF MULTIPARTICULATE FORMULATION AND EVALUATION OF COLON TARGETED DRUG DELIVERY SYSTEM OF CIPROFLOXACIN: IN VIVO STUDY WITH INDUCED COLITIS MODEL IN RATS." Asian Journal of Pharmaceutical and Clinical Research 10, no. 1 (January 1, 2016): 167. http://dx.doi.org/10.22159/ajpcr.2017.v10i1.14634.
Повний текст джерелаАнотація:
ABSTRACTObjective: The objective of this research work was to develop a multiparticulate containing chitosan and guar gum for the treatment of ulcerativecolitis.Method: Method for the formulation of multiparticulate was done by extrusion-spheronization method using Eudragit L-100 and Eudragit S-100 as acoating solution and ciprofloxacin as a model drug.Result: Result from preliminary trial batches was previously assessed for physicochemical characterization, in vitro release, ex vivo mucoadhesionstudy, swelling studies, and in vivo evaluation and showed that the formulations appeared to be a good candidate to deliver the drug to the colon.Box-Behnken design was used to statistically optimize the formulation parameters and evaluate the main effects, interaction effects, and quadraticeffects of the process parameters of enteric-coated multiparticulate on drug polymer ratio and coat composition. In this work, the effectivenessof optimized batch (C4) in the treatment of inflammatory bowel disease was evaluated. Experimentally, colitis was induced by rectal instillationof 2, 4, 6, trinitrobenzene sulfonic acid into male Wistar rats. The histological evaluations were done as inflammatory indices. In vivo gammascintigraphy studies of multiparticulate without a drug demonstrate degradation of multiparticulate whenever they reach colon.Conclusion: The conclusion from results of studies such as gamma scintigraphy and histological study of optimized formulation (C4) clearly indicatesthat there is a great potential in delivery of ciprofloxacin to the colonic region. The animals treated with ciprofloxacin (C4) formulation had animprovement in pathology and may be useful for the treatment of inflammatory bowel disease.Keywords: Chitosan, Guar gum, Ciprofloxacin, Gamma scintigraphy, Histology, Ulcerative colitis, Box-Behnken design.
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Shaikh, Bilal Jilani, Indrayani D. Raut, Manojkumar M. Nitalikar, Shrinivas K. Mohite, and Chandrakant S. Magdum. "An Overview on In-Situ Gel: A Novel Drug Delivery System." International Journal of Pharmaceutical Sciences and Nanotechnology(IJPSN) 15, no. 5 (October 1, 2022): 6180–89. http://dx.doi.org/10.37285/ijpsn.2022.15.5.10.
Повний текст джерелаАнотація:
Controlled and sustained drug delivery has recently become the industry standard, and extensive research has been conducted in order to improve drug product effectiveness, reliability, and safety. The ‘in-situ gel' system has emerged as one of the best innovative drug delivery systems; its unique feature of ‘Sol to Gel' transition aids in the sustained and controlled release of drugs. A formulation that is in solution form before entering the body, but changes to gel form under certain physiological conditions, is known as an in-situ gelling system. The advantages of in-situ forming polymeric delivery systems, including simplicity of administration and reduced frequency of administration, increased patient compliance and comfort, have spurred attention. In-situ gels are a type of hydrogel that starts off as a solution and gels when exposed to bodily fluids or changes in pH. Guar gum, gellan gum, xanthan gum, carrageenan, xyloglucan, pectin, chitosan, and thiolated chitosan are some of the polymers employed in in-situ gelling systems. This review focused on introduction, advantages and disadvantages, approaches and mechanism, preparation methods, polymers used, characterization as well as applications.
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Sui, Chunxia, Wenzhao Zhang, Fei Ye, Xiaoming Liu, and Guoping Yu. "Preparation, physical, and mechanical properties of soy protein isolate/guar gum composite films prepared by solution casting." Journal of Applied Polymer Science 133, no. 18 (January 18, 2016): n/a. http://dx.doi.org/10.1002/app.43382.
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Jenifer, Preethi, Mangathayaru Kalachaveedu, Arun Viswanathan, Arumugam Gnanamani, and Mubeena. "Fabricated approach for an effective wound dressing material based on a natural gum impregnated with Acalypha indica extract." Journal of Bioactive and Compatible Polymers 33, no. 6 (September 25, 2018): 612–28. http://dx.doi.org/10.1177/0883911518801046.
Повний текст джерелаАнотація:
Although acute wounds are common, treatment for a scarless condition remains limited and ineffective as medicated dressings act only as an epidermal coverage and no interdermal interactions happen. This study examined the benefit of Acalypha indica, a traditionally acclaimed plant for wound healing, as a three-dimensional nanofibrous dressing. guar gum, a natural polysaccharide, was chosen as the raw material, in combination with a synthetic copolymer polyvinyl alcohol. A series of polymer blend nanofibers made of 3:7 of 1% wt guar and 10% wt polyvinyl alcohol along with varied ratios of A. indica were prepared using electrospinning. The effect of cross-linking by citric acid on the nanofibers was studied using Fourier transform infrared. A 5% wt A. indica content was optimized in the electrospun solution to get nanosized morphology, roughness, water absorbing capacity, thermal stability, and tensile strength. The composite material was found inhibitory to both Gram-positive and Gram-negative strains as measured by zone of inhibition. The ability of the dressing to support and proliferate human dermal fibroblasts was evaluated by cell proliferation assay and Calcein acetomethyl (AM) staining assay. The results confirmed that the composite dressing could support long-term cell growth in the 9-day cell culture study. The incorporation of A. indica to guar/polyvinyl alcohol composite nanofibers has thus resulted in a wound dressing material with nanosized morphology for mimicking the extracellular matrix, surface roughness for the absorbtion of proteins, swelling capacity for the absorption of exudates, antimicrobial activity for prevention of microbial infections, and cell proliferation activity for the complete wound closure. The electrospun guar/polyvinyl alcohol/ A. indica composite which proved to be a suitable dressing for acute wounds when ascertained in vitro can surely be developed as an ethical plant bioactive wound healant.
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Solanke, Nikhil D., and Pradip A. Pawar. "Preparation and study the physical properties of snacks product Chakli by incorporation of gaur gum and gum Arabic." FOOD SCIENCE RESEARCH JOURNAL 11, no. 2 (October 15, 2020): 70–76. http://dx.doi.org/10.15740/has/fsrj/11.2/70-76.
Повний текст джерелаАнотація:
In this study used of gaur gum and gum arabic in different amounts as independent variables were produced 13 different combinations, two variables, five levels. The purpose of this study was the effect of gaur gum and gum arabic on physical properties of chakli sample using response surface methodology. Multiple regression equations were obtained to describe the effects of each variable on product responses. From this study it was concluded that, optimum solution by numerical optimization for chakli content gaur gum content 1.45 g, gum arabic content 1.82 g and optimized condition for deep fat fried snacks chakli given best snacks product with positive results that increased in water solubility index and lateral expansion while negative effect on moisture content, shearing force and hygroscopicity.
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Shaikh, Hamid M., Arfat Anis, Anesh Manjaly Poulose, Niyaz Ahamad Madhar, and Saeed M. Al-Zahrani. "Development of Bigels Based on Date Palm-Derived Cellulose Nanocrystal-Reinforced Guar Gum Hydrogel and Sesame Oil/Candelilla Wax Oleogel as Delivery Vehicles for Moxifloxacin." Gels 8, no. 6 (May 24, 2022): 330. http://dx.doi.org/10.3390/gels8060330.
Повний текст джерелаАнотація:
Bigels are biphasic semisolid systems that have been explored as delivery vehicles in the food and pharmaceutical industries. These formulations are highly stable and have a longer shelf-life than emulsions. Similarly, cellulose-based hydrogels are considered to be ideal for these formulations due to their biocompatibility and flexibility to mold into various shapes. Accordingly, in the present study, the properties of an optimized guar gum hydrogel and sesame oil/candelilla wax oleogel-based bigel were tailored using date palm-derived cellulose nanocrystals (dp-CNC). These bigels were then explored as carriers for the bioactive molecule moxifloxacin hydrochloride (MH). The preparation of the bigels was achieved by mixing guar gum hydrogel and sesame oil/candelilla wax oleogel. Polarizing microscopy suggested the formation of the hydrogel-in-oleogel type of bigels. An alteration in the dp-CNC content affected the size distribution of the hydrogel phase within the oleogel phase. The colorimetry studies revealed the yellowish-white color of the samples. There were no significant changes in the FTIR functional group positions even after the addition of dp-CNC. In general, the incorporation of dp-CNC resulted in a decrease in the impedance values, except BG3 that had 15 mg dp-CNC in 20 g bigel. The BG3 formulation showed the highest firmness and fluidity. The release of MH from the bigels was quasi-Fickian diffusion mediated. BG3 showed the highest release of the drug. In summary, dp-CNC can be used as a novel reinforcing agent for bigels.
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Palakurthi, Sushesh Srivatsa, Deeksha Jakka, Harpreeth Singh, Sahithi Bollavaram, Sininandini B, Durga Nitya Pinnamraju, and Abbulu Konde. "Preparation and Evaluation of Chewable Tablets of Syzygium cumini Seed Powder." Journal of Drug Delivery and Therapeutics 10, no. 3 (May 15, 2020): 58–64. http://dx.doi.org/10.22270/jddt.v10i3.4069.
Повний текст джерелаАнотація:
Aim of this study is to develop chewable tablets of Syzygium cumini seed powder. It has been chosen to do so as there are no oral solid dosage forms of this seed powder developed so far. There are numerous health benefits and nutrient properties of this seed powder, thus it can be used as a nutraceutical. Phytochemical screening of the Syzygium cumini seed powder has been conducted and the various phyto constituents present were detected. Seven different formulations have been developed by direct compression method out of which five were optimized. All these formulations were developed with Syzygium cumini seed powder as the active ingredient and lactose, acacia, glucose, talc, magnesium stearate, hydroxy propyl methyl cellulose, sodium alginate, guar gum and stevia were used as excipients. Various evaluations tests were performed to check the stability of the chewable tablets. Fourier Transform Infrared Spectroscopy (FTIR) analysis was conducted to check the interactions among the seed powder and the excipients. Anti-bacterial activity of the chewable tablets was tested against three different species of bacteria (Escherichia coli and Bacillus subtilis) by agar diffusion method. It is concluded that the Syzygium cumini seed powder and the developed chewable tablets were active against Escherichia coli and Bacillus subtilis.
Keywords: Syzygium cumini, Chewable tablet, anti-bacterial activity
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Palakurthi, Sushesh Srivatsa, Deeksha Jakka, and Durga Nithya Pinnamraju. "Preparation and Evaluation of Oral Thin Films of a Natural Product: Syzygium cumini seed powder." Journal of Drug Delivery and Therapeutics 12, no. 1-S (February 15, 2022): 64–70. http://dx.doi.org/10.22270/jddt.v12i1-s.5343.
Повний текст джерелаАнотація:
Aim of this project is to develop oral thin films of Syzygium cumini seed powder. Though there were chewable tablets of Syzygium cumini reported in the literature, it has been chosen to formulate oral thin films of Syzygium cumini seed powder as they are expected to be more accepted by pediatrics, over the chewable tablets. Because of its high health benefits, these dosage forms have a potential to be nutraceuticals. Various phyto constituents present in the Syzygium cumini seed powder were screened through phytochemical screening. Four different formulations of oral thin films have been developed out of which two were optimized. Oral thin films were formulated with Syzygium cumini as the active ingredient and hydroxy propyl methyl cellulose, sodium alginate, glucose, guar gum, stevia, polyethylene glycol, water and dichloromethane were used as excipients. Different evaluation studies were performed for the oral thin films. Fourier Transform Infrared Spectroscopy (FTIR) analysis was performed for the oral thin films to check the interactions between the active ingredients and the excipients. Antibacterial activity of the oral thin films was performed against two different bacterial species viz, Escherichia coli and Bacillus subtilis. It is concluded that the developed oral thin films were depicting antibacterial activity.
Keywords: Syzygium cumini, oral films, natural product, nutraceuticals, anti-bacterial activity
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Varma, M. Mohan, and H. L. N. Rao. "Evaluation of Aceclofenac Loaded Alginate Mucoadhesive Spheres Prepared by Ionic Gelation." International Journal of Pharmaceutical Sciences and Nanotechnology 5, no. 4 (February 28, 2013): 1847–57. http://dx.doi.org/10.37285/ijpsn.2012.5.4.4.
Повний текст джерелаАнотація:
Controlled release aceclofenac spheres were prepared in a cross-linked alginate matrix using ionotropic gelation technique. A suspension of aceclofenac in sodium alginate solution was added drop wise into 10% w/v calcium chloride solution and the resulting spheres were evaluated for their drug content, flow properties, mucoadhesive property and the dissolution rate. The aceclofenac loaded alginate spheres were prepared using various mucoadhesive polymers: sodium alginate, HPMC, sodium CMC, guar gum, methyl cellulose and carbopol. The calcium chloride was used as the crosslinking agent. Fourier transform infrared spectroscopy (FTIR) was used to evaluate the drug-polymer interaction. The alginate spheres showed good rheological properties, drug content uniformity and high entrapment efficiency. The aceclofenac release from the spheres was slow and extended up to 10 hours. The drug loaded spheres exhibited good mucoadhesive property in the in vitro wash off test. The drug release from the optimized formulation (drug-sodium alginate-HPMC K15M; 1:0.9: 0.1 ratio) followed zero order kinetics and exhibited non-Fickian diffusion. The rate of release of aceclofenac decreased with increasing concentration of sodium alginate due to slow penetration of dissolution fluid in the spheres. The results suggest that alginate spheres can potentially deliver aceclofenac at zero-order controlled release following oral administration. The FTIR studies indicated the absence of the drug-polymer interaction in the solid state.
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Sulaiman, Halah Talal, Saba Abdulhadi Jabir, and Khalid Kadhem Al-kinani. "INVESTIGATING THE EFFECT OF DIFFERENT GRADES AND CONCENTRATIONS OF PH‑SENSITIVE POLYMER ON PREPARATION AND CHARACTERIZATION OF LIDOCAINE HYDROCHLORIDE AS IN SITU GEL BUCCAL SPRAY." Asian Journal of Pharmaceutical and Clinical Research 11, no. 11 (November 7, 2018): 401. http://dx.doi.org/10.22159/ajpcr.2018.v11i11.28492.
Повний текст джерелаАнотація:
Objective: The present study was aimed to develop a pH-triggered in situ gel for local release of lidocaine hydrochloride (lidocaine HCL) in the buccal cavity to improve the anesthetic effect of this amino amide drug which has very high water solubility. The formulations were introduced to the oral cavity as a spray to improve compliance and for easier administration.Methods: In this work, two grades of carbopol (934 and 940)-based in situ gel spray were designed. The formulations containing lidocaine HCl 5% were prepared by mixing different concentrations of carbopol with xanthan gum. Eight formulations were investigated and evaluated for gelation capacity, spray angle, volume of solution delivered per each actuation, rheological properties, and release kinetic model. Similarity factor (f2) was used for the comparison of dissolution profiles.Results: The prepared formulations undergo gelation after it had been actuated to the buccal cavity as a spray solution. The results showed that, as the concentration of polymer was increased, the release of drug decreased and the viscosity increased for both grades. The spray angle and volume of solution delivered per each actuation varied according to the composition of each formulation. The in situ gel containing 0.3% carbopol 934 and 0.2% xanthan gum regarded as a better candidate which had a good gelation and release property compared to other formulations. Drug release from optimized in situ gel spray followed Korsmeyer–Peppas model and was mediated by Fickian diffusion mechanism.Conclusion: Lidocaine HCl-loaded pH-sensitive in situ gel was successfully developed using carbopol 934 as polymer to be applied to the buccal cavity as spray solution for more effective anesthetic effect and painless treatment.
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Yuan, Jia, Xinzhong Wu, Xiaolan Shi, Feng Xiao, and Xiongjun Xu. "Preparation of Cobalt–Chromium Alloy Planting Materials and Its Application in the Treatment of Gum Restoration." Science of Advanced Materials 12, no. 10 (October 1, 2020): 1508–16. http://dx.doi.org/10.1166/sam.2020.3845.
Повний текст джерелаАнотація:
The preparation of cobalt–chromium alloy materials by different processes was studied and used to repair the full crown of experimental dogs. First, the casting method combined with 3D printing to obtain a cobalt–chromium alloy test piece, and the mechanical and microscopic properties of the test piece were analyzed during the preparation process; And then, selective laser melting (SLM) was used to perform single-channel, single-layer, and multi-layer scanning on the specimens obtained based on this technology during the preparation process. Two kinds of samples were selected from the cobalt–chromium test pieces obtained by the casting method, which were CS01 and CS02. And then selected one kind of sample from the cobalt–chromium test piece obtained by the SLM method, which was SLM01. Firstly, the roughness and contact angle of the planting material were compared, and the saliva-streptococcus mutant cell culture solution was configured to compare the amount of cell adhesion on the surface of different planting materials. Finally, the planting materials were used to repair the dog's full crown and establish animal models. The expressions of Bcl-2, Bax, Ki67 and p53 genes in gingival cells before and after canine crown wearing were compared in gingival tissues. The test results show that the mechanical properties and microstructure of the cobalt–chromium alloy material obtained based on the casting method meet the requirements. Based on the cobalt–chromium test piece obtained by the SLM method, the process parameters were optimized so that the corresponding density of the test piece reached 98.3%; Comparing roughness and surface contact angle, there was no statistical difference between different planting materials (P > 0.05 ). At the same time, the number of Streptococcus mutant adhered to the surface of different specimens was not statistically significant (P > 0.05 ); In the expression of gingival tissue, the implant material was obtained based on the SLM01 test piece, which promoted the decrease of Ki67 gene expression (P < 0.05 ), and also promoted the proliferation of other gingival cell genes (P < 0.05 ).
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Siriwardana, Jayani, and Isuru Wijesekara. "Analysis of the Effectiveness of an Antimicrobial Edible Coating Prepared from Sweet Whey Base to Improve the Physicochemical, Microbiological, and Sensory Attributes of Swiss Cheese." Advances in Agriculture 2021 (March 11, 2021): 1–13. http://dx.doi.org/10.1155/2021/5096574.
Повний текст джерелаАнотація:
In this research, an edible coating was developed to improve the physicochemical, microbiological, and sensory attributes of Swiss cheese using sweet whey as the main ingredient (84.1%wt/wt). Glycerol (5%wt/wt), sunflower oil (10%wt/wt), guar gum (0.7%wt/wt), and Tween 20 (0.2%wt/wt) were used as other ingredients. Use of sweet whey provided an antibacterial function due to the presence of lactic acid. Delvocid was used as the antifungal agent as it contains 50% of natamycin. In this research, antimicrobial efficiency of three Delvocid concentrations—0.250 g/L (solution 1), 0.275 g/L (solution 2), and 0.300 g/L (solution 3)—was determined. Subsequently, microbial, sensory, and physicochemical properties (hardness, moisture, weight loss, color, pH, fat, and salinity) of the antimicrobial edible solution-coated Swiss cheese obtained at 0, 10, 20, 40, and 60 days of storage at 10°C and 85% relative humidity (RH) were compared with those of commercial paraffin-coated and uncoated Swiss cheeses. Antimicrobial edible solution-coated cheeses exhibited decreased moisture loss, pH change, hardness, color change, salinity change, and fat change. Sensory evaluation tests were carried out by 10 trained panelists using seven-point hedonic scales. Solution 3-coated cheeses obtained the highest acceptability score on 20, 40, and 60 days of storage and exhibited an acceptable and relatively low level of Coliform, yeast, and mold counts throughout the storage. As such, solution 3 was selected as the best Delvocid concentration for coating preparation. Shelf life analysis of antimicrobial edible coating solutions revealed that the shelf life of solutions 2 and 3 extended up to 60 days, while that of solution 1 extended up to 40 days at 8°C and 85% RH. Proximate analysis according to the standard Association of Official Analytical Collaboration (AOAC) procedures revealed that total solid, moisture, protein, fat, total ash, lactose, titratable acidity, and antioxidant activity of the antimicrobial edible coating solution were 25.34% (wt/wt), 74.66% (wt/wt), 8.63% (wt/wt), 11.87% (wt/wt), 0.81% (wt/wt), 3.80% (wt/wt), 0.09% (v/v), and 37.13% (Au/Au), respectively.
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Zyaitdinov, Damir, Alexandr Ewteew, and Anna Bannikova. "Immobilization of Oat Bran Polyphenols in Complex Coacervates of Whey Protein and Malthodextrin." Food Processing: Techniques and Technology 50, no. 3 (October 12, 2020): 460–69. http://dx.doi.org/10.21603/2074-9414-2020-3-460-469.
Повний текст джерелаАнотація:
Introduction. Bioactive compounds are a very popular topic of modern food science, especially when it concerns obtaining polyphenols from cereals. The antiradical, antioxidant, and anti-inflammatory properties of these ingredients allow them to inhibit and prevent coronary, artery, and cardiovascular diseases, as well as several types of cancer. Encapsulation is an effective technology that protects bioactive ingredients during processing and storage. In addition, it also prevents any possible interaction with other food constituents. The research objective was to obtain effective tools of controlled delivery of bioactive compounds. The study featured whey protein as a wall material in combination with maltodextrin to encapsulate the bioactives from oat bran.
Study objects and methods. The processed material was oat bran. The technology of its biotransformation was based on ultrasound processing and enzymatic hydrolysis. The antioxidant properties were determined using a coulometer of Expert – 006-antioxidants type (Econix-Expert LLC, Moscow, Russia). Separation and quantitative determination of extract were followed using a Stayer HPLC device (Akvilon, Russia) and a system column Phenomenex Luna 5u C18(2) (250×4.6 mm). The total phenolic content was measured by a modified Folin-Ciocalteu method. To prepare microcapsules, whey protein concentrate (WPC) and maltodextrin (MD) solutions were mixed at ratios 6:4, 4:6, and 5:5. After that, the mixes were treated by ultrasonication and 10% w/w of guar gum solution as double wall material. The encapsulation efficiency (EE) was determined as a ratio of encapsulated phenolic content to total phenolic content. A digestion protocol that simulates conditions of the human gastric and intestinal tract was adapted to investigate the release kinetics of the extracts.
Results and discussion. Ferulic acid is the main antioxidant in cereals. Its amount during extraction was consistent with published data: 9.2 mg/mL after ultrasound exposure, 9.0 mg/mL after enzymatic extraction, and 8.6 mg/mL after chemical treatment. The antioxidant activity of the obtained polyphenols was quite high and reached 921 cu/mL. It depended on the concentration of the preparation in the solution and the extraction method. The polyphenols obtained by ultrasonic exposure and enzyme preparations proved to have a more pronounced antioxidant activity. The highest EE (95.28%) was recorded at WPC:MD ratio of 60:40. In vitro enzymatic hydrolysis protocol simulating digestion in the gastrointestinal tract was used to study the effect of capsule structural characteristics on the kinetics of polyphenol release. The percentage of o polyphenols released from capsules ranged from 70% to 83% after two hours of digestion, which confirmed the effectiveness of microencapsulation technology.
Conclusion. The research confirmed the possibility of using polyphenols obtained by the biotechnological method from oat bran as functional ingredients. Eventually, they may be used in new functional products with bifidogenic properties. Whey protein can be used to encapsulate polyphenols as the wall material of microcapsules.
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Kumari J, Krishna, Bandaru Hemanth Kumar, and Prasanthi D. "Natural Gums and Mucilage as Gelling agents in Topical Gel Formulation." Research Journal of Pharmacy and Technology, October 21, 2022, 4681–86. http://dx.doi.org/10.52711/0974-360x.2022.00785.
Повний текст джерелаАнотація:
The study was conducted to study the gelling efficiency of natural gums (tamarind seed gum) and mucilage (moringa mucilage) using ibuprofen as model drug. Topical drug delivery (TDS) eliminates first pass metabolism and improves bioavailability. Hydrogels are dispersions of network of polymer chains in water as colloidal gels. Ibuprofen an anti-inflammatory, was chosen as a model drug in the preparation of hydrogel for site targeted action and to avoid side effects. Physical properties like swelling index, solubility, loss on drying, flow properties were evaluated. Chemical characterization of isolated gum and mucilage revealed presence of polysaccharides. Ibuprofen topical gels with natural gum (tamarind seed gum (1-7%), moringa mucilage (2-8%) were compared with official xanthan gum (1-4%), guar gum (1-3%) as natural gelling agents and HPMC K4M (1-6%), HPMC K100M (1-6%) and sodium alginate (2-6%) as semi synthetic gelling agents. Drug and excipients are compatible with each other by FTIR studies. The prepared gel formulations were evaluated for clarity, homogeneity, spreadability, drug content, in-vitro diffusion, ex-vivo permeation, skin irritation and stability studies. All formulations have shown better physicochemical properties. Based on the maximum percentage of drug release, formulations containing natural polymers tamarind seed gum (5%), moringa mucilage (8%), xanthan gum (4%), guar gum (3%) were optimized. And semi synthetic polymers HPMC K4M (4%), HPMC K100M (3%), sodium alginate (6%) were optimized. NF10 formulation with guar gum (3%) is optimized based on the percentage of drug release (27.0±0.14%) for 8 hrs, flux of (427.2±0.09µg/cm2/hr), cumulative amount of drug permeated Q8 (329±1.53µg/cm²) and permeability coefficient of (17.08±1.04 ×10-3cm/hr) when compared with tamarind gum (5%), NF1 (23.8±0.13%), (290±1.04µg/cm²), (376.6±0.04µg/cm2/hr), (15.04±0.03×10-3cm/hr) and moringa mucilage (8%), NF3 (14.3±0.19%), (175±0.90µg/cm²), (227.1±0.03µg/cm2/hr), (9.08±0.02×10-3cm/hr). The drug release pattern was found to follow first order kinetics and korsemeyer peppas release mechanism with fickian diffusion release. Formulations were found to be non-irritant and stable. Tamarind gum and moringa mucilage were efficient as gelling agent in preparation of ibuprofen topical gel but showed retarding effect when compared with official guar gum.
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Tiwari, Gaurav, Garima Singh, Ravi Shekhar, and Ruchi Tiwari. "Development and qualitative evaluation of periodontal gel containing an antibacterial agent for periodontal disease." Research Journal of Pharmacy and Technology, November 24, 2022, 5225–31. http://dx.doi.org/10.52711/0974-360x.2022.00880.
Повний текст джерелаАнотація:
The present study aims at the development and evaluation of dental gel containing metronidazole non-biodegradable polymers for targeted delivery of drug and thus prolonging the action. Hot Method was used for the preparation of gel. Natural polymers like, Guar gum, Sodium alginate, Chitosan, Xanthan gum, Gellan gum were used in the formulations of gel. Prepared gels were evaluated for pH, rheological study, spreadability study, gelation, and gel melting study. At last Field Emission Scanning Electron Microscopy FESEM, Differential Scanning Calorimetry (DSC), Thermo Gravimetric Analysis (TGA), Texture Profile Analysis (TPA) have been done on an optimized gel formulation. All gels revealed pH ranged between 6.16 to 6.47, spreadability between 28.37 to 45.03 g.cm/sec, drug content between 90.01 to 99.10 % viscosity ranged between 3108.44 cps and 3645.47 cps and formulations F3 and F10 showed gelation temperature 39±0.12OC and 37±0.13OC respectively which is similar to the temperature of the body. Surface of the sample gels showed no drug particles, indicating a homogeneous mixture of polymers of drugs as well as natural agents. Formulation F10 containing Guar gum showed slower degradation in all media as compared to gels made of Sodium alginate, Xanthan gum, Chitosan, Gellan gum. DSC results revealed that the drug has the same state in the optimized formulation. TGA results showed that the formulation was found to have high stability in high-temperature settings. TPA results of optimized F10 revealed the parameters Mucoadhesive strength 92.54 ± 2.65 g, Hardness 25.34 ± 0.01N/mm², Compressibility 57.75 ± 0.40N mm, Adhesiveness−4.56 ± 0.26 N mm, Cohesiveness 0.83 ± 0.06. Hence, it is concluded that Metronidazole gel with gellan gum showed a longer degradation time and guar gum showed slower degradation in all over polymers used in gel formulations.
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Rathi, Sanjesh, Sohansinh Vaghela, Raj Shah, and Shrenik Shah. "Formulation and Evaluation of Gastroretentive Floating Tablets of Febuxostat." Research Journal of Pharmacy and Technology, October 31, 2021, 5359–65. http://dx.doi.org/10.52711/0974-360x.2021.00935.
Повний текст джерелаАнотація:
The present research work done with an objective of preparation and evaluation of floating tablets of Febuxostat drug with Hydroxypropylenemethyl cellulose (HPMC), Polyox N-60K, Carbopol 934 P and Guar gum polymers. Floating tablets were based on effervescent approach using sodium bicarbonate a gas releasing agent. Direct compression method was used in present study for preparation of tablets. Effect of polymers was evaluated by studying drug release and floating time. In-vitro drug release profile indicates that sustained nature increased by increasing the concentration of polymer. The formulation containing Polyox N-60K and Carbopol 934 P in combination was optimized as it showed drug release up to 12hrs. Optimized formulation F18 was found stable during stability condition up to 1 month.
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Rathi, Sanjesh G., and JayKumar G. Chaudhari. "Formulation and Evaluation of Floating Tablets of Tofacitinib Citrate." International Journal of Pharmaceutical Sciences Review and Research 69, no. 1 (July 15, 2021). http://dx.doi.org/10.47583/ijpsrr.2021.v69i01.025.
Повний текст джерелаАнотація:
The present research work done with an objective of preparation and evaluation of floating tablets of Tofacitinib Citrate drug with Hydroxy propylene methyl cellulose (HPMC), Polyox N-60K, Carbopol 934 P and Guar gum polymers. Floating tablets were based on effervescent approach using sodium bicarbonate a gas releasing agent. Direct compression method was used in present study for preparation of tablets. Effect of polymers was evaluated by studying drug release and floating time. In-vitro drug release profile indicates that sustained nature increased by increasing the concentration of polymer. The formulation containing Polyox N-60K and Carbopol 934 P in combination was optimized as it showed drug release up to 12hrs. Optimized formulation F18 was found stable during stability condition up to 1 month.
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Dabi, Neetu, and Sangeeta Loonker. "Preparation and Characterization of polysaccharide based superabsorbent nanocomposite and its use in efficient removal of Methylene blue dye." Ecology, Environment and Conservation, May 31, 2022, 492–98. http://dx.doi.org/10.53550/eec.2022.v28i03s.072.
Повний текст джерелаАнотація:
Novel guar gum-g-poly acrylic acid (GG-g-PAA) superabsorbent nanocomposites were prepared in aqueous solution using guar gum (GG), partially neutralized acrylic acid (AA), hydrogen peroxide (HP) as an initiator and N, N-methylene bisacrylamide (MBA) as crosslinkerby free radical graft copolymerization reaction. FTIR spectra confirmed that AA had been grafted onto GG chains. X-ray diffraction (XRD) to study its crystalline nature of the composite. Scanning Electron Microscopy (SEM) results shows that prepared composite have uneven and coarse surface. The present study concerns for the removal of Methylene blue dye using GG-g-PAA superabsorbent nanocomposite. The adsorption behavior of dye was studied using batch techniques at different pH values. The synthesized superabsorbent composite (SAC) was found to be effective in removing methylene blue dye up to 90 % at pH 8.5. The effect of various variables such as dye concentration, contact time, adsorbent dose, pH etc. was analyzed. Study shows that the adsorption kinetics favors pseudo second order reaction kinetics. The process of adsorption of dye follows Langmuir and Freundlich model.
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Naeini, Ali Hosseinian, Mohammadreza Kalaee, Omid Moradi, Ramin Khajavi, and Majid Abdouss. "Eco-friendly inorganic-organic bionanocomposite (Copper oxide — Carboxyl methyl cellulose — Guar gum): Preparation and effective removal of dye from aqueous solution." Korean Journal of Chemical Engineering, March 15, 2022. http://dx.doi.org/10.1007/s11814-022-1074-7.
Повний текст джерела
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Mehralian, Mohammad, Ahmadreza Fallah Faraghe, and Mohammad Khajeh Mehrizi. "Novel guar gum/MnO2 nanocomposite for photocatalytic degradation of reactive yellow (RY 145) from aqueous solution: optimization by BBD." Pigment & Resin Technology, September 9, 2022. http://dx.doi.org/10.1108/prt-06-2022-0081.
Повний текст джерелаАнотація:
Purpose This study aims to investigation of the guar gum-manganese dioxide (GG/MnO2) nanocomposite (NC) synthesized using an environment-friendly method and the degradation of reactive yellow (RY 145) dye in the UV system. Design/methodology/approach Characterization of the GG/MnO2 NCs were conducted using field emission scanning electron microscopy, X-ray diffraction and Fourier-transform infrared spectroscopy. Experiments were conducted using a 1 L glass reactor coupled with Ultraviolet (UV-C) blue light bulb of wavelength 250 nm and power of 8 W. Findings The NC (2.25 g/L) displayed high RY 145 dye degradation (81%) with 10 mg/L of concentration at pH 3. The coefficient of determination (R2 0.99) also depicted that the model fits the experimental data. The analysis of variance (ANOVA) showed that the F-values of 464.75, 276.04 and 5.15 are related to the dose of GG/MnO2 NCs, initial concentration of RY 145 dye and solution pH, respectively. Practical implications The GG/MnO2 NCs followed by photo oxidation process (UV-process) could be used to degrade the RY 145 dye from synthetic wastewater. Originality/value There are two main innovations. One is that the novel process is performed successfully for RY 145 dye degradation. The other is that the optimized conditions are obtained by Box–Behnken design. Also, the effects of different variables on the RY 145 dye removal efficiency were investigated.
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Kumar, M. Pradeep, G. Suryanarayana Murthy, A. Sreekanth, BV Ramana, and Badithala Siva Sai Kiran. "Design and Evaluation of Mebeverine Hydrochloride Microspheres with Novel Timed Release Polymers." International Journal of pharma and Bio Sciences 13, no. 2 (April 25, 2022). http://dx.doi.org/10.22376/ijpbs.2022.13.2.p9-15.
Повний текст джерелаАнотація:
Drugs having the shorter half life are needed to be administered frequently in order to maintain the required therapeutic concentrations. One of the strategies to overcome the frequent administration is by developing the controlled release formulations. Microspheres including the micro particles and microcapsules (having a core of the drug) of 1-1000 μm in diameter are one of the emerging controlled drug delivery systems that can eliminate the frequent drug administration. Hence, in the present study an effort was made to formulate microsphere of Mebeverine HCl by using different delayed-released polymers at different concentrations. Different formulations were prepared using guar gum and glutaraldehyde as delayed release polymers and evaluated for the properties like the effect of polymer concentrations on the microsphere formation, particle size, muco-adhesion etc. Also, the prepared microspheres were evaluated for flow properties along with the drug release rates. From the results, it was observed that higher concentrations of polymer resulted in better microsphere formation compared to low concentrations. Projection Microscopic images of optimized formulation showed that the microspheres have rough surface. In vitro drug release studies showed that the optimized formulation showed 96.26 percent Mebeverine HCl release at the end of 13 hours. Overall, it can be concluded that the preparation of Mebeverine HCl microspheres can eliminate the need for frequent administration thereby providing the better therapeutic compliance compared to the conventional dosage forms.
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Rani, E. Veena. "Formulation and Evaluation of Sintered Gastroretentive Tablets of Pioglitazone." International Journal of Pharmaceutical Sciences Review and Research 69, no. 1 (July 15, 2021). http://dx.doi.org/10.47583/ijpsrr.2021.v69i01.007.
Повний текст джерелаАнотація:
The aim of the present study is to prepare sintered gastroretentive tablets of Pioglitazone and to study the effect of sintering on invitro dissolution study, hardness and friability. Sintering is defined as the process of compaction or formation of compact at a temperature below the melting point of solid constituent for the purpose of increasing its strength by bonding the particles together. EVA 1802, stearic acid, carnauba wax, and natural polymers like almond gum, xanthun gum, guar gum were used. The tablets were prepared by direct compression and wet granulation technique using PVP as binder and EVA, carnauba wax, stearic acid in different concentration of 10%, 15% were used in preparation. The prepared tablets were subjected to sintering at three different temperatures of 50, 60, 70°C for three different time periods of 1hr, 2hr, 3hrs in hot air oven. Precompression and post compression parameters were performed. Results showed that the release rate of the drug was inversely related to the sintering temperature and time of sintering. The optimum drug retardation occurred in the tablets at 70°C for 3hrs. increasing the temperature and time of exposure to a particular temperature often decreases the release rate of the drug. In addition, the hardness of the sintered tablets was increased with increasing sintering temperature and duration of sintering whereas friability of tablets was found to be decreased with increasing time. The optimized formulations F3(SA+CW+XG), F4(SA+CW+EVA) sintered at 70°C for 3hrs showed the maximum release of 70-80%. from the kinetic profile it shows that the drug release followed zero order and nonfickian diffusion mechanism. Thus, the formulations F3 and F4 was considered to be the best formulations among all the 6 formulations sintered at various temperature and various time periods. Hence it shows the suitability of EVA,SA,CW, natural polymers for preparing the sintered gastroretentive tablets of Pioglitazone.
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R, Vibin Bose. "DESIGN AND DEVELOPMENT OF GASTRORETENTIVE DRUG DELIVERY SYSTEM OF CIPROFLOXACIN HYDROCHLORIDE." Asian Journal of Pharmaceutical and Clinical Research 11 (December 28, 2018). http://dx.doi.org/10.22159/ajpcr.2018.v11s4.31722.
Повний текст джерелаАнотація:
Objective: The aim is to prepare the floating tablet of ciprofloxacin and to improve their bioavailability in the treatment against the Gram-positive and Gram-negative microorganisms. Ciprofloxacin HCL is an acidic drug used for respiratory tract infection, diarrhea, skin infection, thyroid fever, and urinary tract infection. The ciprofloxacin HCL is primarily absorbed in the stomach and it has low bioavailability. Due to its low availability, it was chosen as an appropriate drug for the scheme of the gastroretentive floating drug delivery system. Method: Ciprofloxacin HCl is an acidic drug which was made by wet granulation process using various polymers, which include hydroxypropyl methylcellulose K4M, Eudragit, and Guar gum with a different composition. The gas generating agents such as saleratus and citric acid were used for the preparation. The prepared granules were subjected to pre-compression parameters technique and the formulated tablets were subjected to post-compression parameters, respectively. Result: The Fourier-transform infrared analysis reveal that the drug and excipients used for the formulations were compatible with each other. All formulated granules having good flow properties and all the post-compression parameter are within the limit in which the F4 formulation shows optimum drug release of about 98.7% at 12 h and which has the buoyancy lag time of about 134 s and floating time about 12.5 h. Kinetic treatment revealed of the optimized preparation is based on Korsmeyer–Peppas model. The value n=0.861 states the process of non-Fickian diffusion. Conclusion: Based on above observation found in the work, it was concluded that ciprofloxacin HCl can formulate as a floating drug delivery system which helps in increasing the gastric residence time, as a result, it increases the bioavailability and half-life of ciprofloxacin HCl.