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Готові списки джерел за темами / Optimisation de hit en lead / Книги

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Книги з теми "Optimisation de hit en lead"

Автор: Grafiati

Опубліковано: 29 березня 2025

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1

Faller, Bernard, and Laszlo Urban, eds. Hit and Lead Profiling. Wiley, 2009. http://dx.doi.org/10.1002/9783527627448.

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2

Ramaswamy, Vijayan, and Vasanthanathan Poongavanam. Computational Drug Discovery: From Hit to Lead Optimization. Wiley & Sons, Limited, John, 2023.

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3

Optimisation of Corrosion Control for Lead in Drinking Water Using Computational Modelling Techniques. IWA Publishing, 2013.

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4

Hayes, Colin, Croft, T N. Optimisation of Corrosion Control for Lead in Drinking Water Using Computational Modelling Techniques. IWA Publishing, 2012.

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5

Urban, Laszlo, Gerd Folkers, Raimund Mannhold, Hugo Kubinyi, and Bernard Faller. Hit and Lead Profiling: Identification and Optimization of Drug-Like Molecules. Wiley & Sons, Limited, John, 2010.

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6

Urban, Laszlo, Gerd Folkers, Raimund Mannhold, Hugo Kubinyi, and Bernard Faller. Hit and Lead Profiling: Identification and Optimization of Drug-Like Molecules. Wiley & Sons, Limited, John, 2010.

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7

Urban, Laszlo, Gerd Folkers, Raimund Mannhold, Hugo Kubinyi, and Bernard Faller. Hit and Lead Profiling: Identification and Optimization of Drug-Like Molecules. Wiley & Sons, Limited, John, 2010.

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8

Hit and lead profiling: Identification and optimization of drug-like molecules. Weinheim: Wiley-VCH, 2009.

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9

Urban, Laszlo, Gerd Folkers, Raimund Mannhold, Hugo Kubinyi, and Bernard Faller. Hit and Lead Profiling: Identification and Optimization of Drug-Like Molecules. Wiley & Sons, Incorporated, John, 2009.

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10

Now Lead the Change: Repurpose Your Career, Future-Proof Your Organization, and Regenerate Our Crisis-Hit World by Mastering Transformational Leadership. Switch On Books, 2020.

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11

All Rhodes Lead Here: From the Author of the Sensational TikTok Hit, from LUKOV with LOVE, and the Queen of the Slow-Burn Romance! Headline Publishing Group, 2023.

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12

Oldenburg, Steve. Complete Conditioning for Volleyball. Human Kinetics, 2015. http://dx.doi.org/10.5040/9781718225084.

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From more powerful attacks to higher block points at the net, you will reach new levels of performance on the court with Complete Conditioning for Volleyball. In this one-of-a-kind video-enhanced resource, University of Illinois volleyball strength and conditioning coach Steve Oldenburg provides you with access to the elite-level training that has helped the Fighting Illini become one of the most powerful Division I programs in the country. Before you hit the court for your next match, add a copy of Complete Conditioning for Volleyball to your locker so you can become a dominant player on both ends of the court and lead your team to victory!

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13

Paris, Joel. The Relationship Between Childhood Adversity and Borderline Personality Disorder. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199997510.003.0005.

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Borderline personality disorder (BPD) is often associated with adverse events in childhood. However, early adversity does not necessarily lead to BPD, and not all BPD patients have experienced childhood adversity. The key to understanding this relationship is gene-environment interaction. Children who are vulnerable by temperament are more severely affected by adverse events. This “double hit” is a risk for developing a personality disorder. The missing piece in research on adversity and BPD is longitudinal data. This could involve research in community samples, but the frequency of BPD as an outcome is not high enough to make that strategy effective. Instead, a high-risk strategy is called for, in which children identified as suffering from abuse and neglect are followed well into adulthood. These investigations will need to be multivariate and to take temperament into account.

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14

Kothari, Jaimal, and Marie Scully. Thrombocytopenia in the critically ill. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0272.

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Thrombocytopenia is an extremely common finding in patients in intensive care. This can lead to serious morbidity and mortality from bleeding, and also uncertainty with regards to how to assess this risk in the wider context of the underlying pathology, which may be multifactorial, when specific blood products should be transfused, and the associated risks of carrying out interventional procedures. Haemodilution, platelet consumption, increased platelet destruction, reduced production, and increased sequestration are the main mechanisms that account for thrombocytopenia, and in the ICU setting there is typically an interplay of more than one of these that accounts for the counts seen. Sepsis and disseminated intravascular coagulation are the most common causes of thrombocytopenia in the ICU, with significant overlap between the pathologies. Less common causes in an intensive care unit setting include heparin-induced thrombocytopenia (HIT) and thrombotic thromobocytopenic purpura (TTP). The evidence base surrounding platelet thresholds remains poor and is an active area of research. Anticoagulation in the context of thrombocytopenia is problematic and requires a patient-specific approach.

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15

Aisiku, Imoigele, and Claudia S. Robertson. Epidemiology and pathophysiology of traumatic brain injury. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0341.

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Although medical management of traumatic brain injury (TBI) may have improved in developed countries, TBI is still a major cause of mortality and morbidity. The demographics are skewed towards the younger patient population, and affects males more than females, but in general follow a bimodal distribution with peaks affecting young adults and the elderly. As a result, the loss of functional years is devastating. Pathology due to brain trauma is a complex two-hit phenomenon, frequently divided into ‘primary’ and ‘secondary’ injury. Hypoxia, ischaemia, and inflammation all play a role, and the importance of each component varies between patients and in an individual patient over time. The initial injury may increase intracranial pressure and reduce cerebral perfusion due to the presence of mass lesions or diffuse brain swelling. Further secondary insults, such as hypotension, reduced cerebral perfusion pressure, hypoxia, or fever may exacerbate swelling and inflammation, and further compromise cerebral perfusion. Although there are currently no specific effective treatments for TBI, an improved understanding of the pathophysiology may eventually lead to treatments that will reduce mortality and improve long-term functional outcome.

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16

Guilliams, Todd. High-Scroing Baseball. Human Kinetics, 2013. http://dx.doi.org/10.5040/9781718218734.

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What is the definition of a high-scoring offense? How do you measure a player’s offensive productivity? How do you keep your team on track throughout the course of a long season? High-Scoring Baseball is the definitive guide for establishing an aggressive, opportunistic, and disciplined offense. Inside you’ll find detailed coverage of the four offensive team goals and the six ways to create offensive pressure that gives every team a chance to be high scorers. Then go inside the numbers for an in-depth analysis of run production. Discover the most common predictors for achieving a big inning, the importance of getting the lead-off hitter on, and the importance of collecting free bases. You’ll identify the most effective strategies based on specific game situations as well as the proper mental approach and physical adjustments to execute in those situations. Offense is more than a player’s batting average or a team’s ability to hit the long ball. It’s all about run production. It’s a player’s ability to achieve a high-quality at-bat and a team’s ability to create a big inning. High-Scoring Baseball will change the way you see and play the game.

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17

Kühn, Wolfgang, and Gerd Walz. The molecular basis of ciliopathies and cyst formation. Edited by Neil Turner. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0303.

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Abnormalities of the cilium, termed ‘ciliopathies’, are the prime suspect in the pathogenesis of renal cyst formation because the gene products of cystic disease-causing genes localize to them, or near them. However, we only partially understand how cilia maintain the geometry of kidney tubules, and how abnormal cilia lead to renal cysts, and the diverse range of diseases attributed to them. Some non-cystic diseases share pathology of the same structures. Although still incompletely understood, cilia appear to orient cells in response to extracellular cues to maintain the overall geometry of a tissue, thereby intersecting with the planar cell polarity (PCP) pathway and the actin cytoskeleton. The PCP pathway controls two morphogenetic programmes, oriented cell division (OCD) and convergent extension (CE) through cell intercalation that both seem to play a critical role in cyst formation. The two-hit theory of cystogenesis, by which loss of the second normal allele causes tubular epithelial cells to form kidney cysts, has been largely borne out. Additional hits and influences may better explain the rate of cyst formation and inter-individual differences in disease progression. Ciliary defects appear to converge on overlapping signalling modules, including mammalian target of rapamycin and cAMP pathways, which can be targeted to treat human cystic kidney disease irrespective of the underlying gene mutation.

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18

Cloninger, Susan C., and Steven A. Leibo, eds. Understanding Angry Groups. Praeger, 2017. http://dx.doi.org/10.5040/9798216029304.

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This book examines the dynamics that lead to anger in individuals, within groups, and between groups; identifies the role of the media in angry group behavior; and offers solutions for dealing with angry groups and channeling that negative energy in positive ways. In today’s society, we see angry groups in many forms—from animal rights and climate crisis activists to citizens opposed to allowing more immigrants of certain ethnicities or religions into the country, militia groups frustrated by acts of domestic terrorism and legislation that limits gun ownership and the ability to carry weapons in public, and those outraged by what they see as police brutality or the unnecessary use of deadly force against people of color. More than just evidence of civil unrest in society, angry groups across history and nations often ultimately affect our politics and our government, for better or worse, and sometimes result in injury, bloodshed, or financial costs that hit otherwise-uninvolved taxpayers. This book demonstrates how people across our nation are involved in, affected by, or harmed by angry groups; covers historical and modern perspectives on angry groups; ands offers suggestions for predicting and influencing the expression of angry group behavior. It provides readers with an understanding of such conflicts and of their origins and dynamics that may offer insights to successful resolution, and it identifies strategies that can reduce the suffering that comes from such conflicts.

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19

Erickson, Christina L. Spanked. Oxford University PressNew York, 2022. http://dx.doi.org/10.1093/oso/9780197518236.001.0001.

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Abstract Tracing the history of spanking from our earliest records, the trail of spankings’ influence on society and individuals is explored. The book covers the slow transition from the whip and rod to the hand, the first questioning of spankings’ utility, and the inception of spanking stigma. Stories of religion, school paddling, and the development of child protection in the United States highlight historical factors on the edges of spanking and show their connections to our modern conundrum—why do we hit people smaller than us who we love so much? To understand the real meaning of spanking, the book explores the private lives of family and the public sphere of our social lives. Spanking has been a common and accepted discipline for hundreds of years. Filled with stories of families, researchers, and community organizers, the book helps us see varied angles of family spanking we have avoided for far too long. The research outcomes on spanking are causal and clear, and the data have been repeated in many studies. Brain research, parent child synchrony, touch, trauma, and communication all lead us to new understandings of spanking’s impact on adults and children alike. Maybe most important of all is the question never asked before: Is spanking a child good for the parent? Book group questions and prompts for organizations and professionals provide a framework for conversation and dialogue. A rich appendix includes laws on physical discipline from each state, laws on school paddling, and corporal punishment laws around the world.

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20

Morton, David. Sound Recording. Greenwood, 2004. http://dx.doi.org/10.5040/9798216016700.

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How did one of the great inventions of the 19th century— Thomas Edison's phonograph— eventually lead to one of the most culturally and economically significant technologies of the 20th and 21st centuries?Sound Recordingtells that story, tracing the history of the business boom and the cultural revolution begun by Edison's invention. Ever since, recorded sound has been all around us—not just in reproducing and playing popular music, but also in more mundane areas, such as office dictation machines, radio and television programs, and even telephone answering machines. Just as the styles of music have evolved over the years, the formats on which this music was played have changed as well —from 78s to LPs, from LPs to cassette tapes, from cassettes to CDs—not to mention lesser-known innovations in the motion picture and television industries. The quest for better sound was one of the drivers of technological change, but so too were business strategies, patent battles, and a host of other factors. Sound Recordingcontains much information that will interest anyone interested in the history of recorded music and sound technology, such as: • The world-famous composer John Phillip Sousa once denounced sound recordings as a threat to good musical tasted. He nonetheless made many recordings over the years • Two innovative new products were introduced by RCA in 1958—the first modern cassette tape cartridge and the stereophonic LP record. The tape cartridge, which was about the size of a large paperback, flopped almost immediately; the stereo LP was the music industry's biggest hit ever • Chrysler automobiles of the late 1950s offered Highway Hi-Fi, a dashboard phonograph that could play a record without skipping • The predecessor of the Compact Disc was a 12-inch home videodisc system from the late 1970s—the first of its kind—called DiscoVision The volume includes a timeline and a bibliography for those interested in delving further into the history of recorded sound.

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