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Статті в журналах з теми "Oocyte-secreted"
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Hussein, Tamer S., Jeremy G. Thompson, and Robert B. Gilchrist. "Oocyte-secreted factors enhance oocyte developmental competence." Developmental Biology 296, no. 2 (August 2006): 514–21. http://dx.doi.org/10.1016/j.ydbio.2006.06.026.
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Gilchrist, Robert B., Michelle Lane, and Jeremy G. Thompson. "Oocyte-secreted factors: regulators of cumulus cell function and oocyte quality." Human Reproduction Update 14, no. 2 (January 5, 2008): 159–77. http://dx.doi.org/10.1093/humupd/dmm040.
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Vanderhyden, Barbara C. "Oocyte-secreted factros regulate granulosa cell steroidogenesis." Zygote 4, no. 04 (November 1996): 317–21. http://dx.doi.org/10.1017/s0967199400003324.
Повний текст джерелаАнотація:
Investigations of strains of mice defective in germ cell development have revealed the importance of oocytes for the initial stages of folliculogenesis (Pellaset al., 1991; Huanget al., 1993). Various aspects of follicular development are dependent upon and/or influenced by the presence of oocytes, including granulosa cell proliferation (Vanderhydenet al., 1990, 1992) and cumulus expansion (Buccioneet al., 1990; Salustriet al., 1990; Vanderhydenet al., 1990; Vanderhyden, 1993). We are investigating the possibility that oocytes influence one of the primary functions of granulosa cells: steroidogenesis. In many species, granulosa cells removed from preovulatory follicles luteinisein vitro(Channinget al., 1982), presumably due to loss of contact with follicular luteinisation inhibitory factor(s). Indeed, follicular fluid can prevent granulosa cell luteinisationin vitro(Ledwitz-Rigbyet al., 1977). Follicular fluid, however, may simply be the medium for transport of factors secreted by oocytes to regulate granulosa cell activities.
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Gilchrist, Robert B. "Actions of Oocyte-Secreted TGFbeta Superfamily Ligands." Biology of Reproduction 78, Suppl_1 (May 1, 2008): 279–80. http://dx.doi.org/10.1093/biolreprod/78.s1.279b.
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da Silveira, Juliano C., Ana Clara F. C. M. de Ávila, Hannah L. Garrett, Jason E. Bruemmer, Quinton A. Winger, and Gerrit J. Bouma. "Cell-secreted vesicles containing microRNAs as regulators of gamete maturation." Journal of Endocrinology 236, no. 1 (January 2018): R15—R27. http://dx.doi.org/10.1530/joe-17-0200.
Повний текст джерелаАнотація:
Mammalian gamete maturation requires extensive signaling between germ cells and their surrounding somatic cells. In the ovary, theca cells, mural granulosa cells, cumulus cells and the oocyte all secrete factors throughout follicle growth and maturation that are critical for ovulation of a high-quality oocyte with the competence to develop into an embryo. Similarly, maturation of sperm occurs as it transits the epididymis during which epididymal epithelium and sperm exchange secretory factors that are required for sperm to gain motility and fertility. Recent studies in a variety of species have uncovered the presence of cell-secreted vesicles in follicular fluid (microvesicles and exosomes) and epididymal fluid (epididymosomes). Moreover, these cell-secreted vesicles contain small non-coding regulatory RNAs called microRNAs, which can be shuttled between maturing gametes and surrounding somatic cells. Although little is known about the exact mechanism of how microRNAs are loaded into these cell-secreted vesicles or are transferred and modulate gene expression and function in gametes, recent studies clearly suggest that cell-secreted vesicle microRNAs play a role in oocyte and sperm maturation. Moreover, a role for cell-secreted vesicular microRNAs in gamete maturation provides for novel opportunities to modulate and discover new diagnostic markers associated with male or female fertility. This manuscript provides an overview of cell-secreted vesicles in ovarian follicular fluid and epididymal fluid and microRNAs and discusses recent discoveries on the potential function of cell-secreted vesicles as carriers of microRNAs in oocyte and sperm maturation.
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Cakmak, Hakan, Federica Franciosi, A. Musa Zamah, Marcelle I. Cedars, and Marco Conti. "Dynamic secretion during meiotic reentry integrates the function of the oocyte and cumulus cells." Proceedings of the National Academy of Sciences 113, no. 9 (February 10, 2016): 2424–29. http://dx.doi.org/10.1073/pnas.1519990113.
Повний текст джерелаАнотація:
The differentiation of the female gamete into a developmentally competent oocyte relies on the protected environment of the ovarian follicle. The oocyte plays a key role in establishing this microenvironment by releasing paracrine factors that control the functions of surrounding somatic cells. Growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) are secreted during follicle growth and play pivotal roles in this local regulation. The current view is that the function of these secreted factors declines in the periovulatory period when the oocyte reenters the meiotic cell cycle. Here, we provide evidence that oocyte reentry into meiosis is instead associated with a shift in the pattern of secretion with a new set of bioactive molecules synthesized before ovulation. Using interleukin 7 (IL7) as a prototypic secreted factor, we show that its secretion is dependent on activation of mRNA translation in synchrony with the cell cycle and that its translation is under the control of somatic cells. IL7 is part of a local feedback loop with the soma because it regulates cumulus cell replication. Similar conclusions are reached when IL7 secretion is measured in human follicular fluid during in vitro fertilization cycles. IL7 concentration in the follicular fluid correlates with the oocyte ability to reach the MII stage of maturation. These findings are consistent with the hypothesis that a new set of local factors is secreted by the oocyte during ovulation. These dynamic secretions are likely critical for promoting the final stages of maturation and oocyte developmental competence.
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Yan, Changning, Frank L. Pendola, Renu Jacob, Anthony L. Lau, John J. Eppig, and Martin M. Matzuk. "Oosp1 encodes a novel mouse oocyte-secreted protein." genesis 31, no. 3 (2001): 105–10. http://dx.doi.org/10.1002/gene.10010.
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RICHANI, Dulama, Yiqing ZHAO, Xiuhua LIAO, Jared M. CAMPBELL, Abbas HABIBALAHI, William A. STOCKER, Ewa M. GOLDYS, Craig A. HARRISON, and Robert B. GILCHRIST. "Novel Oocyte-Secreted Factors Improve Mouse IVM Outcomes." Fertility & Reproduction 04, no. 03n04 (September 2022): 132. http://dx.doi.org/10.1142/s2661318222740449.
Повний текст джерелаАнотація:
Background: In vitro maturation (IVM) is a technology designed to obtain mature oocytes following culture of immature cumulus–oocyte complexes (COC) in vitro. IVM is characterized by minimal patient stimulation, making it attractive for patients with excessive AFC or those requiring immediate fertility preservation. However, the clinical uptake of IVM has been slow, primarily due to lower embryo yield and live birth rate relative to IVF, therefore improving IVM culture is required. Aim: To assess whether supplementation of IVM culture medium with the novel in-house engineered TGFβ proteins cumulin and super-GDF9 improves subsequent embryo development. Method: Immature mouse COCs were cultured by standard IVM or bi-phasic IVM ± cumulin or super-GDF9. Following IVM, cumulus expansion was scored and COCs were fertilized, and cultured to assess embryo development. Differential staining was performed on day 6 blastocysts following bi-phasic IVM to assess cell allocation. In a separate experiment, hyperspectral imaging of autofluorescence was carried out on oocytes and cumulus cells following standard IVM ± cumulin to assess the molecular composition of these cells. Results: Both cumulin and super-GDF9 in standard IVM significantly increased cumulus expansion (P<0001; n=104-115 COCs) and blastocyst rate (53.9% control, 73.6% cumulin, 70.4% super-GDF9; P=0.006; n=382-406 oocytes). Hyperspectral imaging showed that oocytes (n=115-158) and cumulus cells (n=532-600) exposed to cumulin during IVM had a distinct spectral profile that varied dramatically (P<0.005) from untreated cells, demonstrating that cumulin has a major impact on the molecular composition of these cells, likely contributing to the improved oocyte quality. In bi-phasic IVM, cumulin did not significantly alter embryo yield (n=387-424 oocytes) or blastocyst cell number or allocation (n=84-112 blastocysts). Conclusion: Cumulin did not provide an additional beneficial effect in bi-phasic IVM, however in standard IVM, cumulin and super-GDF9 significantly improve oocyte developmental competence suggesting that their effects in human IVM should be investigated.
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Dragovic, Rebecca A., Lesley J. Ritter, Samantha J. Schulz, Fred Amato, David T. Armstrong, and Robert B. Gilchrist. "Role of Oocyte-Secreted Growth Differentiation Factor 9 in the Regulation of Mouse Cumulus Expansion." Endocrinology 146, no. 6 (June 1, 2005): 2798–806. http://dx.doi.org/10.1210/en.2005-0098.
Повний текст джерелаАнотація:
Abstract Oocyte-secreted factors are required for expansion of the mouse cumulus-oocyte complex, which is necessary for ovulation. Oocyte-secreted growth differentiation factor 9 (GDF9) signals through the bone morphogenetic protein receptor II and is currently the primary candidate molecule for the cumulus-expansion enabling factor. This study was conducted to determine whether GDF9 is the mouse cumulus-expansion enabling factor. Cumulus-oocyte complexes were collected from mice, and the oocyte was microsurgically removed to generate an oocytectomized (OOX) complex. OOX complexes treated with FSH alone or recombinant mouse GDF9 alone failed to expand, whereas expansion was induced in the presence of FSH by GDF9, TGFβ1, or coculture with oocytes. A specific GDF9-neutralizing antibody, mAb-GDF9–53, neutralized the expansion of OOX complexes in response to GDF9 but not the expansion of OOX complexes cocultured with oocytes. Using real-time RT-PCR, hyaluronan synthase 2 (HAS2) mRNA expression by OOXs was up-regulated 4- to 6-fold by oocytes and GDF9. Monoclonal neutralizing antibody-GDF9–53 attenuated GDF9-induced OOX HAS2 expression but not oocyte-induced HAS2 expression. A TGFβ antagonist neutralized TGFβ-induced, but not oocyte-induced, expansion of OOX complexes, and when combined with monoclonal neutralizing antibody-GDF9–53 also failed to neutralize oocyte-induced expansion. Furthermore, a soluble portion of the bone morphogenetic protein receptor II extracellular domain, which is a known GDF9 antagonist, completely antagonized GDF9-induced expansion but only partially neutralized oocyte-induced expansion. This study provides further evidence that like TGFβ, GDF9 can enable FSH-induced cumulus expansion, but more importantly, demonstrates that neither GDF9 nor TGFβ alone, nor the two in unison, account for the critical oocyte-secreted factors regulating mouse cumulus expansion.
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Hussein, Tamer S., Melanie L. Sutton-McDowall, Robert B. Gilchrist, and Jeremy G. Thompson. "Temporal effects of exogenous oocyte-secreted factors on bovine oocyte developmental competence during IVM." Reproduction, Fertility and Development 23, no. 4 (2011): 576. http://dx.doi.org/10.1071/rd10323.
Повний текст джерелаАнотація:
We investigated whether paracrine signalling between the bovine oocyte and cumulus cells is altered during the course of in vitro maturation (IVM). Bovine COCs were cocultured with denuded oocytes or treated with specific oocyte-secreted factors, namely recombinant bone morphogenetic protein (BMP)-15 or growth differentiation factor (GDF)-9, beginning from 0 or 9 h IVM. To generate a 9-h denuded oocyte (DO) group, COCs were cultured intact for the first 9 h of IVM and then denuded. Coculturing intact COCs with DOs denuded immediately after collection or following 9 h of maturation did not affect cleavage rate, but improved blastocyst yield (P < 0.05) on Day 8 (51 and 61%, respectively; P < 0.05) and cell number compared with COCs cultured alone (41%). Significantly, we observed higher levels of endogenous GDF-9 and BMP-15 protein in oocytes of COCs matured for 9 h compared with no incubation. The addition of 175 ng mL–1 GDF-9 or 10% v/v BMP-15 from partially purified transfected 293H cell supernatant for 24 h IVM significantly enhanced development to the blastocyst stage from 40% (control) to 51 and 47%, respectively (P < 0.05). However, treatment of COCs with GDF-9 or BMP-15 between 9 and 24 h of IVM did not increase blastocyst yield. These results provide evidence of quantitative and possibly qualitative temporal changes in oocyte paracrine factor production during IVM.
Дисертації з теми "Oocyte-secreted"
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Brankin, Victoria. "Porcine oocyte secreted factors and somatic ovarian cell growth and function." Thesis, University of Nottingham, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.395710.
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Dhawan, Anil. "The role of oocyte- and embryo-secreted factors in cumulus cell differentiation and their relationship to embryo quality and developmental competence." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0028/MQ52295.pdf.
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Lopes, Eliana Franco. "Expressão gênica em complexos cumulus-oócito bovinos selecionados pela atividade da glicose-6-fosfato desidrogenase." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2013. http://hdl.handle.net/10183/72040.
Повний текст джерелаАнотація:
O objetivo desse trabalho foi avaliar a expressão de genes envolvidos no transporte de monocarboxilatos (Mct1, Mct2, Mct3 e Mct4) e de genes específicos da oogênese (Bmp15, Gdf9 e Has2) em complexos cumulus-oócito (CCOs) selecionados pelo teste BCB. Após seleção morfológica com base no grau de compactação das células do cumulus (CCs) e no grau de homogeneidade do citoplasma, os CCOs foram corados com 26 μM BCB (azul cresil brilhante) por 90 min e divididos em dois grupos: BCB+, que apresentavam o ooplasma corado de azul, e BCB-, com ooplasma não corado. Foram utilizados dois grupos controles não expostos ao BCB: o grupo holding foi submetido às mesmas condições que os grupos corados e o outro grupo controle foi diretamente submetido à maturação in vitro (MIV), após a seleção morfológica dos CCOs. A expressão gênica relativa foi determinada por RT-PCR em CCOs coletados antes e ao final da maturação. A expressão também foi avaliada, separadamente, em oócitos desnudos (ODs) e células do cumulus (CCs) antes e após a maturação. A análise dos transcritos demonstrou que houve aumento significativo (p < 0,05) na expressão relativa de Gdf9 e Bmp15 nos grupos BCB+, BCB- e holding antes da MIV, enquanto Has2 teve aumento significativo (p < 0,01) após a MIV apenas no grupo controle. Os outros genes analisados (Mct1, Mct2 e Mct4) mantiveram-se estáveis durante a maturação. O aumento na abundância relativa de alguns transcritos durante a MIV pode ser atribuído as condições de incubações durante o teste BCB. Nossos resultados demonstraram, pela primeira vez, a expressão de Mct1, 2 e 4 em CCOs bovinos. Enquanto o mRNA de Mct1 e Mct4 estava presente em ODs e em CC, o Mct2 foi detectado somente em CCs. Não detectamos a expressão de transcritos de Mct3 em CCOs. As diferenças na expressão dessas três isoformas sugerem um papel único para esses transportadores durante a maturação.The aim of this study was to determine the relative expression of genes involved in transport of monocarboxylates (Mct1, Mct2, Mct3 e Mct4) and oogenesis specific genes (Bmp15, Gdf9 and Has2) in immature and mature bovine cumulus-oocyte complexes (COC) after selection by BCB. Immature COCs underwent morphological selection and were stained with 26 mM BCB for 90 min. Based on ooplasm staining, oocytes were distributed in two groups BCB+ (blue color) and BCB- (non-stained). The holding control group was exposed to the same incubation conditions as stained COCs, but without BCB. Control group was submitted to in vitro maturation (IVM) immediately after morphological selection. mRNA expression was investigated by RT-PCR in COCs before and after IVM. No relationship was observed in the relative expression of Has2, Gdf9, Bmp15 or Mct1, 2 and 4 transcripts between BCB- and BCB+ COCs. Transcripts analysis showed that Gdf9 and Bmp15 in BCB+, BCB- and holding groups were upregulated (p < 0.05) before IVM, while Has2 was up-regulated (p < 0.01) after IVM in the control group. Others genes remained stable during maturation (Mct1, 2 and 4). The increase in relative abundance of some transcripts during IVM may be attributed to incubation conditions during the BCB test. Our results showed, for the first time, Mct1, 2 and 4 expression in bovine COCs. Mct1 and Mct4 transcripts were present in denuded oocytes and cumulus cell, while Mct2 was detected only in cumulus cells. These differences between the three isoforms in localization suggest unique roles for each in monocarboxylate transport during maturation.
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Hussein, Tamer. "Role of oocyte-secreted factors in prevention of cumulus cell apoptosis and enhancement of oocyte developmental competence." 2006. http://hdl.handle.net/2440/58191.
Повний текст джерелаАнотація:
Title page, table of contents and abstract only. The complete thesis in print form is available from the University of Adelaide Library.Paracrine factors secreted by the oocyte (oocyte-secreted factors, OSFs) regulate a broad range of cumulus cell functions. The capacity of oocytes to regulate their own microenvironment by OSFs may in turn contribute to oocyte developmental competence. The aim of this thesis was to examine whether cumulus cells exhibit a low incidence of apoptosis due to their close association with oocytes and their exposure to OSFs, and to investigate if OSFs have a direct influence on bovine oocyte developmental competence during in vitro maturation (IVM). This thesis includes a series of studies designed to examine by various means the nature of the paracrine network of bone morphogenetic proteins (BMPs) and their binding proteins involved in the regulation of cumulus cell apoptosis. OSFs, in particular BMP- 15 and BMP-6, but not growth differentiation factor 9 (GDF-9), reduced apoptosis of cumulus cells by following a gradient from the site of the oocytes. Morever, follistatin and a BMP6 neutralizing antibody, which antagonized the anti-apoptotic effects of BMP15 and BMP6, respectively, whether alone or combined, blocked ~50% of the antiapoptotic actions of oocytes. These results demonstrated that OSFs, particularly BMP-15 and BMP-6, maintain the low incidence of apoptosis by establishing a localized gradient of bone morphogenetic proteins. Results from the present thesis also demonstrated that OSFs enhance oocyte developmental competence during IVM, whether in their native form as an uncharacterized mix of growth factors secreted by the oocyte, throughout the oocyte maturation period, or as exogenous BMP-15 and GDF-9, during the first 9 hour of IVM. Also, OSFs improved embryo quality as evident by increased blastocyst total and trophectoderm cell numbers. These results were further verified in neutralization experiments of the exogenous growth factors and of the native OSFs. Follistatin and the kinase inhibitor SB-431542, which antagonize BMP-15 and GDF-9, respectively, neutralized the stimulatory effects of the exogenous growth factors, and impaired the developmental competence of control cumulus-oocyte complexes (COCs). The work presented in this thesis has provided multiple lines of evidence that OSFregulation of the COC microenvironment is an important determinant of cumulus cell apoptosis and oocyte developmental programming.
http://proxy.library.adelaide.edu.au/login?url= http://library.adelaide.edu.au/cgi-bin/Pwebrecon.cgi?BBID=1260892
Thesis (Ph.D.) -- University of Adelaide, School of Paediatrics and Reproductive Health, 2006
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Hussein, Tamer. "Role of oocyte-secreted factors in prevention of cumulus cell apoptosis and enhancement of oocyte developmental competence." Thesis, 2006. http://hdl.handle.net/2440/58191.
Повний текст джерелаАнотація:
Paracrine factors secreted by the oocyte (oocyte-secreted factors, OSFs) regulate a broad range of cumulus cell functions. The capacity of oocytes to regulate their own microenvironment by OSFs may in turn contribute to oocyte developmental competence. The aim of this thesis was to examine whether cumulus cells exhibit a low incidence of apoptosis due to their close association with oocytes and their exposure to OSFs, and to
investigate if OSFs have a direct influence on bovine oocyte developmental competence during in vitro maturation (IVM). This thesis includes a series of studies designed to examine by various means the nature of the paracrine network of bone morphogenetic proteins (BMPs) and their binding proteins involved in the regulation of cumulus cell apoptosis. OSFs, in particular BMP- 15 and BMP-6, but not growth differentiation factor 9 (GDF-9), reduced apoptosis of cumulus cells by following a gradient from the site of the oocytes. Morever, follistatin and a BMP6 neutralizing antibody, which antagonized the anti-apoptotic effects of BMP15 and BMP6, respectively, whether alone or combined, blocked ~50% of the antiapoptotic actions of oocytes. These results demonstrated that OSFs, particularly BMP-15 and BMP-6, maintain the low incidence of apoptosis by establishing a localized gradient of bone morphogenetic proteins. Results from the present thesis also demonstrated that OSFs enhance oocyte developmental competence during IVM, whether in their native form as an uncharacterized mix of growth factors secreted by the oocyte, throughout the oocyte maturation period, or as exogenous BMP-15 and GDF-9, during the first 9 hour of IVM. Also, OSFs improved embryo quality as evident by increased blastocyst total and trophectoderm cell numbers. These results were further verified in neutralization experiments of the exogenous growth factors and of the native OSFs. Follistatin and the kinase inhibitor SB-431542, which antagonize BMP-15 and GDF-9, respectively,
neutralized the stimulatory effects of the exogenous growth factors, and impaired the developmental competence of control cumulus-oocyte complexes (COCs). The work presented in this thesis has provided multiple lines of evidence that OSFregulation of the COC microenvironment is an important determinant of cumulus cell apoptosis and oocyte developmental programming.Thesis (Ph.D.) -- University of Adelaide, School of Paediatrics and Reproductive Health, 2006
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Cerqueira, Ana Catarina Sotomaior Neto. "Hormona anti-muleriana e oocyte secreted factors no líquido folicular humano na avaliação de distúrbios da infertilidade." Master's thesis, 2014. https://repositorio-aberto.up.pt/handle/10216/89988.
Повний текст джерела
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Cerqueira, Ana Catarina Sotomaior Neto. "Hormona anti-muleriana e oocyte secreted factors no líquido folicular humano na avaliação de distúrbios da infertilidade." Dissertação, 2014. https://repositorio-aberto.up.pt/handle/10216/89988.
Повний текст джерела
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Martin, Georgia Alice. "GDF9 and BMP15: species difference and synergistic interactions." Thesis, 2014. http://hdl.handle.net/2440/87852.
Повний текст джерелаАнотація:
GDF9 and BMP15 are two oocyte-secreted proteins which have been shown to be essential for normal mammalian fertility. There are a number of factors which impact their efficiency, including species difference of the proteins, GDF9/BMP15 interactions and the presence of post-translational modifications. However, factors such as species difference and post-translational modifications have yet to be investigated in terms of their effects on GDF9/BMP15 interactions. The aims of this study were to produce well purified human and mouse GDF9 and human BMP15 to test the effects of these factors. We found clear species differences between mouse and human GDF9 in thymidine incorporation in mouse and bovine granulosa cells. However, not only did we find a species difference due to the species of the protein, but also a difference due to the species of the cells on which the proteins were acting. GDF9 and BMP15 were found to interact synergistically on mouse granulosa cells, but not on bovine cells. Human GDF9 was found to be dependent on the presence of BMP15 for bioactivity in both species of cell however, the introduction of mouse-like residues into the human GDF9 sequence was able to produce a protein capable of functioning independent of BMP15 and with even higher bioactivity than wild-type mouse GDF9. Post-translational modifications were also found to have significant effects on synergistic GDF9/BMP15 synergistic interactions. Both GDF9 and BMP15 have previously been shown to be phosphorylated. This appears to be more important to the correct functioning of GDF9. Loss of GDF9 phosphorylation was found not only to decrease its bioactivity but also to decrease its synergistic interactions with BMP15. Phosphorylation was not found to affect BMP15 however; the loss of o-linked glycosylation decreased its ability to synergise with GDF9. To fully assess the implications and applications of this work, there is still a great deal of work to be done however, it is clear that for any embryological studies, the species differences of the proteins and cells need to be carefully considered.Thesis (M.Phil.) -- University of Adelaide, School of Paediatrics and Reproductive Health, 2014
Частини книг з теми "Oocyte-secreted"
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Thompson, Jeremy G., David G. Mottershead, and Robert B. Gilchrist. "Oocyte-Secreted Factors in Domestic Animals." In Oocyte Physiology and Development in Domestic Animals, 55–70. Oxford, UK: Wiley-Blackwell, 2013. http://dx.doi.org/10.1002/9781118538074.ch4.
Повний текст джерела