Статті в журналах: "One-day diagnosis"

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Nusynowitz, M. L. "One Day Diagnosis and Treatment of Hyperthyroidism." Clinical Nuclear Medicine 31, no. 4 (April 2006): 244. http://dx.doi.org/10.1097/00003072-200604000-00027.

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Foley, Kevin F. "A Dozen Testosterone Samples From One Patient, on One Day?" Laboratory Medicine 52, no. 1 (June 15, 2020): e5-e7. http://dx.doi.org/10.1093/labmed/lmaa032.

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Abstract The differential diagnosis of female virilization and infertility can be significantly narrowed using routine laboratory testing. The case presented herein is an example of a 28 year old Caucasian female patient with amenorrhea, hirsutism, and infertility in the context of markedly elevated serum testosterone levels. This case highlights the use of bilateral ovarian vein sampling for testosterone as a means to localize the ectopic testosterone production and to guide future surgical procedures. Adrenal vein sampling procedures are relatively more common than other methods. Ovarian vein sampling is less common, yet in this case, it proved diagnostic. This case demonstrates the needed cooperation of the clinical laboratory and the patient care team performing the catheterization, for this type of testing to be useful. In this unique case, we discovered bilateral production of androgens.

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Putnis, S., R. Merville-Tugg, and S. Atkinson. "'One-stop' inguinal hernia surgery – day-case referral, diagnosis and treatment." Annals of The Royal College of Surgeons of England 86, no. 6 (November 1, 2004): 425–27. http://dx.doi.org/10.1308/147870804506.

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PERRY, SARAH HOPKINS. "Caring for Jason ...one day at a time." Nursing 27, no. 10 (October 1997): 46–48. http://dx.doi.org/10.1097/00152193-199710000-00040.

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&NA;. "CAROL WAS UP ONE DAY, DOWN THE NEXT." Nursing 19, no. 1 (January 1989): 44–48. http://dx.doi.org/10.1097/00152193-198901000-00018.

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SANTANABOADO, C. "SPET 99mTc-tetrofosmin perfusion SPECT one day protocol in the diagnosis of CAD." Journal of Nuclear Cardiology 4, no. 1 (February 1997): S35. http://dx.doi.org/10.1016/s1071-3581(97)91252-6.

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7

Falagario, Ugo Giovanni, Oscar Selvaggio, Francesca Sanguedolce, Paola Milillo, Maria Chiara Sighinolfi, Salvatore Mariano Bruno, Marco Recchia, et al. "One-Day Prostate Cancer Diagnosis: Biparametric Magnetic Resonance Imaging and Digital Pathology by Fluorescence Confocal Microscopy." Diagnostics 12, no. 2 (January 21, 2022): 277. http://dx.doi.org/10.3390/diagnostics12020277.

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In this prospective observational study, we tested the feasibility and efficacy of a novel one-day PCa diagnosis path based on biparametric magnetic resonance (bpMRI) and digital pathology by fluorescence confocal microscopy (FCM). Patients aged 55–70 years scheduled for PBx due to increased PSA levels (3–10 ng/mL) and/or abnormal digitorectal examination were enrolled. All patients underwent bpMRI and PBx with immediate FCM evaluation of biopsy cores. Patients were asked to fill out a dedicated Patient Satisfaction Questionnaire. Patients’ satisfaction rates and concordance between digital pathology and standard HE evaluation were the outcomes of interest. Twelve patients completed our one-day PCa diagnosis path. BpMRI showed suspicious lesions in 7 patients. Digital pathology by FCM identified PCa in 5 (41.7%) of the 12 patients. Standard pathology confirmed the diagnosis made through digital pathology in all the cases. At a per patient level, high concordance between the methods was achieved in Gleason Grading (4 out of 5 patients). The level of agreement in the number of positive cores was lower but did not affect the choice of treatment in any of the 5 PCa cases. At a per core level, the agreement was very high for the diagnosis of anyPCa (96.2%) and csPCa (97.3%), with a k coefficient of 0.90 and 0.92, respectively (near perfect agreement). In conclusion, one-day PCa diagnosis by FCM represents a feasible, reliable, and fast diagnostic method that provides significant advantages in optimizing time and resources, leading to patients having a higher quality standard of care perception.

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Moreira Amorim, Gustavo, Ingrid Reuwsaat Paul, Bruna Molozzi, Elisa Rohsig Dannebrock, Timotio Volnei Dorn, and Roberto Moreira Amorim Filho. "Dermoscopy’s Contribution for the Diagnosis of Folliculotropic Mycosis Fungoides." Dermatology and Dermatitis 6, no. 1 (June 4, 2021): 01–04. http://dx.doi.org/10.31579/2578-8949/071.

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Folliculotropic mycosis fungoides (FMF) is one of the three recognized variants of mycosis fungoides. FMF predominates in men over 50 years old. Often it takes a long time for the definitive diagnosis after the onset of skin lesions. Dermoscopy today represents almost an extension of the clinical dermatological examination, with its application being expanded day after day in medical literature. The authors demonstrate the dermoscopic findings recently described in the context of FMF (follicular accentuation / white halo around the follicles), in a case of typical clinical presentation, with a diagnosis confirmed by the clinical-dermatological correlation.

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Patel, A., A. Schmidt, and M. A. Jackson. "Visual Diagnosis: 20-month-old Boy With a One-Day History of Fever and Cough." Pediatrics in Review 36, no. 7 (July 1, 2015): e22-e25. http://dx.doi.org/10.1542/pir.36-7-e22.

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Patel, Anik, Angela Schmidt, and Mary Anne Jackson. "Visual Diagnosis: 20-month-old Boy With a One-Day History of Fever and Cough." Pediatrics In Review 36, no. 7 (July 1, 2015): e22-e25. http://dx.doi.org/10.1542/pir.36.7.e22.

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Pónusz, R., N. Németh, D. Kovács, B. Molics, D. Endrei, and I. Boncz. "PNS139 EVALUATION OF HUNGARIAN ONE-DAY SURGERY IN LIGHT OF DIAGNOSIS RELATED GROUPSâ€™ VALUE." Value in Health 22 (May 2019): S309. http://dx.doi.org/10.1016/j.jval.2019.04.1496.

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Pessaux, P., V. Faucher, R. Cuny, M. Stephan, F. Klein, C. González, S. Blanes, E. Leost, B. Delattre, and C. Lugiez. "One-day diagnosis for hepatobiliary and pancreatic lesions: An innovative patient-centered care pathway organization." Journal of Visceral Surgery 155, no. 6 (December 2018): 439–43. http://dx.doi.org/10.1016/j.jviscsurg.2018.02.005.

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Glick, Henry, Taiga Miyazaki, Katsuji Hirano, Jose Suaya, Elisa Gonzalez, Bradford D. Gessner, Raul E. Isturiz, Adriano G. Arguedas, and Shigeru Kohno. "1453. Ninety-One Day Quality of Life Post-Pneumonia Diagnosis in Adult Patients in Japan." Open Forum Infectious Diseases 5, suppl_1 (November 2018): S449. http://dx.doi.org/10.1093/ofid/ofy210.1284.

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Mather, Rebecca L., Henry Andrews, Hardev Pandha, Elena Jachetti, Jake Micallef, Yuzhuo Wang, and Francesco Crea. "The Open University's first one-day symposium on treatment-emergent neuroendocrine prostate cancer." Future Oncology 16, no. 6 (February 2020): 147–49. http://dx.doi.org/10.2217/fon-2019-0718.

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The Open University's first one-day symposium on treatment-emergent neuroendocrine prostate cancer attracted world-leading figures, early career researchers and industry colleagues. The symposium proved insightful into the ‘real-world’ impact and current problems faced in the diagnosis and treatment of neuroendocrine prostate cancer. It was important for this meeting to take place as the incidence of neuroendocrine prostate cancer is increasing due to the widespread use of next-generation androgen deprivation drugs. The symposium discussions proposed new molecularly driven deadlines to accelerate research and improved the treatment of this deadly and poorly recognized malignancy.

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Walker, M. P., G. A. Ayre, J. L. Cummings, K. Wesnes, I. G. McKeith, J. T. O'Brien, and C. G. Ballard. "The Clinician Assessment of Fluctuation and the One Day Fluctuation Assessment Scale." British Journal of Psychiatry 177, no. 3 (September 2000): 252–56. http://dx.doi.org/10.1192/bjp.177.3.252.

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BackgroundThe identification of fluctuating confusion is central to improving the differential diagnosis of the common dementias.AimsTo determine the value of two rating scales to measure fluctuating confusion.MethodThe agreement between the clinician-rated scale and the scale completed by a non-clinician was determined. Correlations between the two scales were calculated; variability in attention was calculated on a computerised cognitive assessment and variability in delta rhythm on an electroencephalogram (EEG).ResultsThe Clinician Assessment of Fluctuation and the computerised cognitive assessment were completed for 155 patients (61 Alzheimer's disease, 37 dementia with Lewy bodies, 22 vascular dementia, 35 elderly controls). A subgroup (n=40) received a further evaluation using the One Day Fluctuation Assessment Scale and an EEG. The two scales correlated significantly with each other, and with the neuropsychological and electrophysiological measures of fluctuation.ConclusionsBoth scales are useful instruments for the clinical assessment of fluctuation in dementia.

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Cherkaoui, Zineb, Barbara Seeliger, Vanina Faucher, Céline Biermann, Arne Kock, and Patrick Pessaux. "Evaluation of an Innovative Care Pathway in the Diagnostic and Therapeutic Management of Hepatobiliary and Pancreatic Pathologies: “One-Day Diagnosis”." Journal of Personalized Medicine 13, no. 1 (December 21, 2022): 12. http://dx.doi.org/10.3390/jpm13010012.

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“One-Day Diagnosis” (1DD) for hepatobiliary and pancreatic (HBP) diseases is an innovative care pathway that combines, on the same day, surgical consultation, medical imaging, anesthesia, diagnosis announcement, and therapeutic support consultations. The objective was to evaluate the length of the 1DD care pathway compared to a conventional one. The prospective “1DD care pathway” arm included 330 consecutive patients (January 2017–April 2019) vs. 152 (November 2014–November 2015) in the retrospective “conventional” one. In the 1DD group, diagnosis was made on the same day in 83% of consultations vs. 68.4% (p = 0.0005). Although there was no difference in overall time to diagnosis, diagnostic and therapeutic management was faster in the 1DD group (1 day vs. 15 days, p < 0.0004). In addition, 77% of patients who benefited from 1DD were very satisfied with their treatment overall. The mean cost of the 1DD consultation was EUR 176.8 +/− 149 (range: 50–546). The median cost of the overall program was similar (EUR 584 vs. EUR 563, p = 0.67). As an organizational innovation, the 1DD for HBP pathologies is a promising care pathway that optimizes diagnostic and therapeutic management, without creating medical overconsumption or additional costs. Given patient satisfaction, this model should be generalized to optimize cancer care by adapting it to the constraints of different healthcare structures.

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Pradhan, Gourahari, Manoranjan Pattnaik, HemantaKumar Sethy, Jyoti Patnaik, Thitta Mohanty, and PradeepKumar Giri. "Diagnosis and treatment of pulmonary tuberculosis in one day : Way forward for END TB Strategy 2015." Journal of Family Medicine and Primary Care 8, no. 1 (2019): 184. http://dx.doi.org/10.4103/jfmpc.jfmpc_358_16.

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Noriega-Álvarez, Edel, María T. Bajén, Julio Rodríguez-Rubio, Ana M. Benítez, Alba Rodrígez-Gasén, Judith Suils, Rafael Jaller, Guillermo A. Martínez, Inmaculada Romero, and Jaime Mora. "One-day protocol versus two-day protocol in acquisition of scintigraphy with “in vitro” labelled white blood cells for diagnosis of osteoarticular infection." Revista Española de Medicina Nuclear e Imagen Molecular (English Edition) 37, no. 5 (September 2018): 277–84. http://dx.doi.org/10.1016/j.remnie.2018.03.003.

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Saifullah Khan Niazi, Aymen Bibi, Eijaz Ghani, Ali Rathore, Hammad Hussain, and Hina Hammad. "Significance of Serological Markers in Diagnosis of Acute Dengue Infection: 2021 Outbreak." Pakistan Armed Forces Medical Journal 74, no. 2 (April 29, 2024): 429–32. http://dx.doi.org/10.51253/pafmj.v74i2.8942.

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Objective: To highlight the significance of Dengue anti-IgM and Dengue NS1 antigen in diagnosing Acute Dengue infection. Study Design: Cross-sectional study. Place and Duration of Study: Virology Department, Armed Forces Institute of Pathology, Rawalpindi Pakistan, from Sep to Nov 2021. Methodology: One hundred and fifty Dengue NS1-positive patients of either gender with age≥5 years were included. ELISA tested patients for detection of Dengue anti-IgM antibody. A questionnaire was used to collect demographic and personal data of each patient. Results: Out of 150 dengue NS1 positive samples, 26(17%) were positive for dengue anti-IgM. In collected samples, Dengue serological markers (NS1 and anti-IgM) positivity was observed based on ‘the day of onset of symptoms. On days 1 and 2, 54 and 44 NS1 positive samples were collected, respectively, but no one was found positive for anti-IgM. Anti-IgM was detected on day-3 and onwards. 27% Dengue anti-IgM positivity was found on day-3, which increased gradually as the time of infection increased. On day four, it was 53%; on day 5, it was 55%; on day-6, it was 60%; on day 7, it was 75%; and on day 8, it was 100%. Conclusions: The findings of present study suggested that anti-Dengue IgM antibodies are less significant than the Dengue NS1 antigen in diagnosing acute dengue infection.

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A, Ravi Teja. "Sonographic Eye on Dengue during Clinical Evaluation and Early Diagnosis in Children." Pediatrics & Neonatal Biology Open Access 4, no. 2 (2019): 1–4. http://dx.doi.org/10.23880/pnboa-16000142.

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The study was done during epidemic of dengue in South India tertiary paediatric Hospital during 2019, for a period of one mon th. Role of ultrasound in early identification of dengue and its complications along with clinical and laboratory investigations. Ultrasound was performed on 112 patients (1 – 14 years) referred from dept. of paediatrics for ultrasound with features of dengu e and its complication and later confirmed the diagnosis with serology proven. 30 patients were serologically negative for dengue fever hence excluded from the study. Out of 92 serologically positive cases 31 cases visited hospital at early stage and under gone ultrasound during 2/3 rd day and 5/7 th day of fever. During 2/3 rd day ultrasound showed as almost all showed gall bladder wall thickening and pericholecystic fluid (in different patterns), 32.5% had hepatomegaly, 16.12% had splenomegaly and 19.35% righ t minimal pleural effusion, 3.25% left plural effusion. Follow - up ultrasound on fifth to seventh day revealed ascites in 93.5%, hepatomegaly in 90.3%, right plural effusion 80.6%, left pleural effusion in 41.9% and pericardial effusion in 29%. Of the 61 pa tients who underwent the study on fifth to seventh day of fever for the first time almost all had gall bladder wall thickening, 95.0%had hepatomegaly, 27.8% had splenomegaly, 96.7% had ascites, 95.08% had right pleural effusion, 75.4% had left pleural effu sion and 22.9% had pericardial fluid. To conclude, in an epidemic of dengue, ultrasound features of thickened gall bladder wall, pleural effusion heaptomegaly and ascites should strongly favour the diagnosis of dengue fever.

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Budiono, Novericko Ginger, Rahmaulana Bayu Dewaruci, Nurul Annisa Tuliman, Zahrizada Zamrudina Dewaruci, and Arni Diana Fitri. "Diagnosis and Treatment of Constipation and Bladder Contusion Hematuria Due to Trauma in a Cat." Jurnal Veteriner 24, no. 3 (September 30, 2023): 279–94. http://dx.doi.org/10.19087/jveteriner.2023.24.3.279.

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A two-year-old, spayed female, calico, domestic shorthair cat (Felis catus) was admitted to IPB University Veterinary Teaching Hospital with a history of hematuria, constipation, and inappetence after being hit by a car. Clinical examination showed pyrexia and the presence of pain when the patient was palpated in the abdomen. Laboratory results showed leukocytosis, lymphocytosis, increased glutamic-oxaloacetic transaminase, increased blood urea nitrogen, proteinuria, over-creatinine, as well as blood and struvite in the urine. The radiographic analysis reported abnormalities in os vertebrae lumbalis I and radiolucent of the colon and rectum. Sonographic findings were cholecystitis, cholelithiasis, nephritis, enteritis, and cystitis. The treatments given were intravenous infusion with normal saline, a single Melovem® injection 0.35 cc, Dulcolax® one 5 mg tablet SID for two days, Samylin®Medium Breed ½ tablet once a day, Cystaid Plus® for cats SID one tab, phytomenadione injection 3 mg/kg SID for two days, Claneksi® syrups 20 mg/kg of body weight per oral BID for five days, Renate® SID per oral for eight days. On the second day of hospitalization, the patient had not pooped, so intra-rectal flushing with physiologic saline was performed, and the patient pooed with normal consistency each day after the enema procedure. Hematuria was observed during the first two days of hospitalization, while no hematuria was observed on the third day. The patient recovered after three days of hospitalization with no hematuria or other abnormal clinical signs or complications. The veterinarian discharged the patient with home treatment with the remaining oral medications.

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Haponiuk, Ireneusz, Maciej Chojnicki, Aneta Szofer-Sendrowska, Jacek Juscinski, Mariusz Steffens, Radoslaw Jaworski, Iwona Domzalska-Popadiuk, Katarzyna Gierat-Haponiuk, Katarzyna Leszczynska, and Krzysztof Preis. "“Planned” permanent pacemaker implantation in one-day-old newborn after prenatal diagnosis of congenital complete atrioventricular heart block." Polish Journal of Cardio-Thoracic Surgery 1 (2014): 76–78. http://dx.doi.org/10.5114/kitp.2014.41937.

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Kahraman, D., and S. Sahinduran. "DIAGNOSIS OF PERSISTENT BVD IN ONE DAY OLD AND OLDER THAN 30 DAYS CALVES WITH RAPID KIT TESTS." Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies 18, no. 4(72) (October 13, 2016): 96–106. http://dx.doi.org/10.15421/nvlvet7201.

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Bovine Viral Diarrhoea (BVD) is an important disease of cattle which causes alimentary, respiratory and reproductive disorders and serious economic losses. Today, eradication of disease is compulsory for the increase of dairies and achieving more healthier herds. In cattle, if the calves are infected with BVD from the uterus in the first trimester of pregnancy, they are born persistent infected (PI) antigen(+). The PI calves are smaller or normal in apperance than normal calves. Persistent infected (PI) calves spread the virus throughout their lives and infect their surroundings. BVD causes early embrionic death, calves born with anomalies and immunosuppression in infected animals. In this study 200 calves between 1–30 days old from Burdur province are screened with BVD rapid test kit. In the screening, 13 calves (6.5%) are found BVDV ag(+). The gender of PI calves are found 4% female (8/200) and 2.5% male (5/200). In the 5% of PI calves (10/200), respiratory and alimentary problems were clinically seen. The antigen(+) animals are put out of the herd and vaccination protocols are recommended. In this study, diagnosing the disease can be made rapidly by both clinicians and farmers, also putting the virus spreading persistent calves out of herd without losing time and a successful struggle can be made against BVD, are shown.

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Almendra, R., A. R. Figueiredo, V. Espirito Santo, A. Almeida, P. Guimarães, and A. G. Velon. "Tardive dyskinesia: When one should suspect of another diagnosis?" European Psychiatry 33, S1 (March 2016): S375. http://dx.doi.org/10.1016/j.eurpsy.2016.01.1347.

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IntroductionTardive dyskinesia is a collection of symptoms related to the side effects of neuroleptic medications that can mimic other types of disorders. Accurate diagnosis can be challenging, as there is no single test for tardive dyskinesia.Case reportFemale patient, 64 years old, with personal history of Chronic Myeloid Leukaemia and psychosis since forth decade, currently medicated with quetiapine 350 mg/day, risperidone IM 50 mg 15/15 days and trazodone 150 mg/day (previously medicated with haloperidol, amisulpride and olanzapine). She started with involuntary movements interpreted as tardive dyskinesia after 2 years on neuroleptic treatment. The difficult control of involuntary movements motivated the reference to ambulatory Neurology department. The review of personal history suggested a family history of involuntary movements and psychiatric illness. Physical examination showed generalized choreic movements. The analytical and imagiologic study was unremarkable. The presence of family history and involuntary movements atypical to be classified as tardive dyskinesia supported a genetic test for Huntington's disease who detected a CAG expansion with 43 repetitions in HTT gene. Despite treatment with amantadine and riluzole she maintains disease progression and evident cognitive deterioration.ConclusionThe diagnostic process of involuntary movements may involve more than one physician and requires the review of a detailed medical history, a physical examination and a neuropsychological evaluation in order to determine whether one is indeed suffering from tardive dyskinesia or a different neurological disorder.Disclosure of interestThe authors have not supplied their declaration of competing interest.

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Howell, D. N., A. LeFurgey, A. Tuszynski, and J. D. Shelburne. "Telemicroscopy in Pathology Diagnosis." Microscopy and Microanalysis 7, S2 (August 2001): 846–47. http://dx.doi.org/10.1017/s1431927600030300.

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Telepathology, derived from the Greek words tele, or “far off,” and pathologia, literally, “study of the emotions,” is a branch of telemedicine in which information about tissue or body fluid samples obtained at one location is transmitted to a distant site for analysis. in its broadest sense, telepathology can be thought of as encompassing any form of remote information transfer about specimens harboring potential disease processes, including verbal communication via telephone. in a majority of cases, however, the term is used to describe interactions involving transmission of microscopic images, or telemicroscopy. Such transmission can occur through a wide variety of media; sharing of printed images is one venerable mechanism that persists in robust form to this day, facilitated and expedited by efficient express-mail systems. Increasingly, however, the terms telepathology and telemicroscopy have acquired the connotation of rapid electronic transmission of digitized images. Facsimile transmission of micrographs is a rudimentary version of this process, but most modern systems employ some form of digital camera attached to a microscope.

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Sturua, Darejan G., Nino J. Jojua, and Tamar T. Dundua. "X-RAY DIAGNOSIS OF LUNG HYPOPLASIA." Caucasus Journal of Medical and Psychological Sciences 1, no. 2-3 (October 10, 2023): 52–56. http://dx.doi.org/10.61699/cjmps-v1-i2-3-p52-56.

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Pulmonary hypoplasia is a rare form of congenital disorder that leads to the underdevelopment of structural elements of the lungs. Although rare, it is associated with significant neonatal morbidity and mortality. Congenital lung abnormalities are frequently discovered in the early life following routine radiographic imaging and investigations. We report the case of a baby, at the age of one day. He was transferred to the NICU (Neonatal Intensive Care Unit, Tbilisi) with acute respiratory failure. This case report aims to aid future early detection to achieve better diagnostic outcomes.

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Love, Bryan, Christopher Finney, and Jill Gaidos. "P133 PRESCRIPTION OPIOID USE AMONG VETERANS WITH INFLAMMATORY BOWEL DISEASE." Inflammatory Bowel Diseases 26, Supplement_1 (January 2020): S27. http://dx.doi.org/10.1093/ibd/zaa010.063.

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Abstract Background Opioids are commonly prescribed to manage pain in patients with IBD despite increasing evidence of harm associated with chronic use. The aim of the current study was to describe trends in opioid use among veterans with IBD. Methods This was a retrospective cohort study derived from the Veterans Affairs (VA) Health Care System. A unique patient identifier facilitated longitudinal evaluation of electronic databases that include medical diagnoses, surgical procedures, pharmaceuticals, labs, vital status information, dates of treatment, and radiology findings. Veterans were labeled as having IBD if there were at least 2 outpatient or 1 inpatient health care encounters with an ICD-9/10 diagnostic code consistent with IBD from fiscal years 2002 to 2016. Veterans without a minimum of 2 years of follow-up or who had a cancer diagnosis within 1 year before or after IBD diagnosis were excluded. In order to standardize the quantity of opioid exposure, morphine milligram equivalents (MME) for each prescription was calculated using published conversion factors. Individual prescriptions with missing quantity or day’s supply and prescriptions exceeding 1000 MME/day were excluded. Opioid exposure during the first year following the initial diagnosis date was determined as the average MME/day for those with at least one opioid prescription. Annual opioid prescribing rates per 100 IBD patients were calculated. Comorbidities were assessed using a modified Charlson Comorbidity Index (CCI), excluding cancer from the calculation. Results During the study period, 65,817 veterans with IBD were identified. The majority were males (92.1%), Caucasian (78.2%), and had a mean age of 58.2 years. In total, 1,471,019 individual opioid prescriptions were evaluated. The quantity and rate of opioid prescriptions peaked in 2012, with 115,774 unique prescriptions and 698.5 opioid prescriptions per 100 IBD patients, respectively. Twenty-seven percent (n=17,844) of IBD patients had at least one opioid prescription within the initial year of diagnosis. Mean opioid exposure during the initial year of diagnosis averaged 33.2 MME/day, and 12.2% had mean opioid exposure greater than 50 MME/day. Opioid exposure peaked in 2005 at 37.4 MME/day and consistently declined to 29.3 MME/day in 2016. Conclusion There has been a significant decline in opioid prescriptions, prescribing rate, and mean opioid exposure since peaking in 2012. These trends are similar to those seen in the non-veteran US population.

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Falagario, U. G., O. Selvaggio, F. Sanguedolce, P. Milillo, M. C. Sighinolfi, S. M. Bruno, M. Recchia, et al. "One day prostate cancer screening and diagnosis using Magnetic Resonance imaging and Digital Prostate Biopsy with fluorescence confocal microscopy." European Urology 79 (June 2021): S1314—S1315. http://dx.doi.org/10.1016/s0302-2838(21)01308-7.

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Cook, Sara, Thomas Byrnes, Mia Hagen, Albert Gee, Christopher Kweon, and Casey Slattery. "Increased Costs and Health Care Utilization Associated with Delay in Diagnosis of ACL Injuries." Orthopaedic Journal of Sports Medicine 8, no. 7_suppl6 (July 1, 2020): 2325967120S0048. http://dx.doi.org/10.1177/2325967120s00484.

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Objectives: Anterior cruciate ligament (ACL) injuries can be difficult to diagnose, especially among providers with limited musculoskeletal training. Early and accurate diagnosis of ACL injuries is important for initiating proper treatment and limiting inefficient or costly healthcare utilization. We hypothesized that a delayed diagnosis in patients sustaining ACL injuries would result in treatment that is more costly and utilizes more healthcare resource compared to patients diagnosed without delay. Methods: A large national private insurance database (Truven MarketScan) was utilized to identify all patients aged 10-63 years-old diagnosed with an ACL tear from 2011 through 2015. Patients with a possible delay in diagnosis were determined via a database search for the most commonly assigned alternative knee-related diagnosis codes found in patients who were later diagnosed with an ACL tear. Patients were stratified into three groups according to time from non-specific knee diagnosis code to ACL diagnosis: 1) no delay (0 days), short delay (1-30 days) and long delay (>30 days). Subsequent cost and healthcare utilization data including physical therapy, medication use, and number of clinic visits were collected for a period of one-year after initial presentation with an ACL tear or knee-related diagnosis. Results: A search from 2011 through 2015 identified 87,435 patients meeting inclusion criteria that were diagnosed with an ACL injury. There were 24.1% of patients diagnosed at initial presentation whereas 43.5% were diagnosed between one day and 30 days. There were 38.2% of patients that were treated without surgery and had the lowest total cost regardless of delay in diagnosis (Table 1). ACL reconstruction combined with other knee procedures had the highest total cost, particularly with a longer delay in diagnosis. Each day of delay in diagnosis was three times more costly in the non-surgical (additional $27.06 cost per day of delay) versus the surgical groups ($8.09 cost per day of delay). Conclusions: A timely diagnosis of ACL injuries is associated with a lower cost of treatment and less visits to healthcare providers. Non-operative injuries may benefit the most from a timely diagnosis given the high additional cost per day of diagnosis delay. In order to further decrease the burden on the healthcare system, future studies should assess methods than can decrease delays in diagnosis while measuring cost and utilization differences as well as outcomes after ACL tears.

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KAVALIAUSKIENĖ, Liubov, Rimantas PEČIŪRA, and Virginija ADOMAITIENĖ. "Trends in depression diagnosis and consumption of antidepressants in Lithuania in 2004–2009." Acta medica Lituanica 18, no. 1 (January 1, 2011): 17–22. http://dx.doi.org/10.6001/actamedica.v18i1.1809.

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Background. One in five people affected by depression will not recover fully from a first episode, and in 70–80% of those achieving remission, depression will recur. The aim of this study was to evaluate the consumption of antidepressants during six years (2004–2009) in Lithuania, to analyze the trends in the diagnosis of depression and its compliance with the use of antidepressants for the future investigation of rationalizing medicamentous depression treatment costs in Lithuania opportunities. Materials and methods. Data on the total sales of antidepressants were obtained from the IMS (Intercontinental Marketing Service) Health Incorporated. The data were calculated by the DDD (Defined Daily Dose) methodology and expressed in DDDs per 1.000 inhabitants per day. Data on depression diagnosis were obtained from the National Psychiatric Health Centre and expressed as the number of diagnoses in total and by depression types and gender. Results. The total consumption of antidepressants increased from 10.17 DDD / 1000 inhabitants / day in 2004 to 15.0 DDD / 1000 inhabitants / day in 2009. The number of total depression diagnoses increased by 12%. The number of first time diagnosed depression increased not as significantly as relapsed depression diagnoses – by 27%. In 2009, women were diagnosed with depression 4.5 times more frequently than men. Moreover, depression relapse numbers grew up by 33% during the six study years among women. Conclusions. During the study period, the consumption of antidepressants increased by 48%. Women were diagnosed with depression more frequently than men. The results of our study show that the number of depression diagnoses are growing because of depression relapse in women. Keywords: antidepressants consumption, depression relapse, pharmacoeconomics

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Adhikari, Anindya, Ashis Sardar, Tripti Das, Goutam Dey, Prantick Kumar Bhunia, and Debasish Chakraborty. "Diagnostic Diversities of Pus-like Aspirates Encountered during Fine-needle Aspiration Cytology: An Observational Study in a Tertiary Medical Center in Eastern India." CHRISMED Journal of Health and Research 10, no. 4 (October 2023): 329–32. http://dx.doi.org/10.4103/cjhr.cjhr_117_22.

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Abstract Background: Pus-like aspirates (PLAs) are not uncommon in day-to-day cytology practice. An apparently looking simple pus may yield a diagnostic diversity ranging from simple suppurative inflammation to a carcinomatous lesion. Proper processing followed by patient examination may be lifesaving for a patient. Very few cytological studies on PLAs have been conducted in Eastern India. Materials and Methods: One hundred and four PLAs from 104 patients (53 males, 51 females) received during 6 months (January 2022–June 2022) were included in this study. Results: The adult age group (19–60 years) and involvement of the head-and-neck area were most common in this study. The sex ratio (male: female) was almost equal. Simple pyogenic abscess is the most common diagnosis, followed by granulomatous and tuberculous abscess. Some special diagnoses were revealed, such as fungal infection, lymphoma, and carcinoma. Conclusion: This study emphasizes the importance of careful examination of PLAs as it may unmask some special diagnoses, even malignancy too. As a simple and quick outdoor-based study, prompt diagnosis and timely intervention may be lifesaving for some patients.

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Balzer, Boos, Rassaf, Heiss, Preik, Matern, Schoebel, Kelm, and Lauer. ""One-Stop-Shop" ultrasound diagnosis of functional, structural and physicomechanical properties of the brachial artery." Vasa 36, no. 2 (May 1, 2007): 100–106. http://dx.doi.org/10.1024/0301-1526.36.2.100.

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Background: The pathogenesis of atherosclerosis comprises endothelial dysfunction, thickening as well as impaired compliance of the arterial vessel wall. Early assessment of these alterations of the vessel wall at the same site of the vascular tree has yet been hampered by the lack of highly sensitive diagnostic approaches suitable for clinical routine. We therefore aimed to develop and validate a single non-invasive examination of the brachial artery for simultaneous and highly accurate measurement of functional, structural and physicomechanical parameters of the brachial artery. Patients and methods: 20 healthy individuals were investigated using high resolution ultrasound. Flow-mediated dilation (FMD), fractional diameter changes (FDC) and intima-media-thickness (IMT) were measured in the same segment of the brachial artery. Coefficients of variation, day-to-day-variability, between- and within-observer-variability were investigated in 5 individuals. All measurements were performed manually and by an automated PC-based analyzing system. Results: Mean values for all measured parameters were 7.65 ± 0.8% for FMD, 0.02 ± 0.002 for FDC, 0.351 ± 0.007 mm for IMT and followed an even distribution throughout the study population. Automated analysis of coefficient of variation, day-to-day-, between- and within-observer variabilities were: 0.78%, 1.3%, 0.8%, 0.8% (FMD); 4.7%, 2.8%, 4.2%, 2.7% (FDC); 1.8%, 1.1%, 1.9%, 1.1% (IMT). Coefficient of variation, day-to-day-, between- and within-observer variabilities for the manual readings were significantly higher. Conclusions: Functional, structural and physicomechanical parameters of the brachial artery can be quantified consecutively, time-saving and highly reproducibly as an "one-stop-shop" in a single session using high resolution ultrasound with digitized post-processing. This highlights the future possibility of early, sensitive and non-invasive diagnostic testing of vascular function in patients prone to vascular disease.

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Martin, Fern, Lekha Mikkilineni, Kinjal Parikh, Dolores Grosso, Benjamin E. Leiby, Onder Alpdogan, Matthew Carabasi, et al. "Creatinine > 1.5 Mg/Dl and MDS Diagnosis Predicts Poor Outcome Following HSCT." Blood 126, no. 23 (December 3, 2015): 3220. http://dx.doi.org/10.1182/blood.v126.23.3220.3220.

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Abstract Introduction Acute renal failure (ARF) after hematopoietic stem cell transplantation (HSCT) is an important complication associated with transplant-related mortality (TRM). In the first 100 days after HSCT, ARF can be secondary to other major complications, such as sepsis, sinusoidal obstruction syndrome, acute graft-versus-host disease (GVHD), and viral reactivation.ARF also occurs in the setting of nephrotoxic drugs, such as amphotericin B,and calcineurin inhibitors. We hypothesize that risk factors for ARF after HSCT include pre-transplant comorbidities, such as chronic kidney disease (CKD), acute kidney injury (AKI) prior to HSCT and hypertension. Mortality is greater in patients with ARF after HSCT than those without ARF. When ARF requires hemodialysis (HD), the mortality rate rises to greater than 80%. The aim of this study was to identify prognostic indicators for the development of ARF requiring HD or leading to death within 100 days after HSCT. Methods We performed a retrospective analysis of patients undergoing allogeneic HSCT at Thomas Jefferson University Hospital to identify prognostic indicators for poor outcomes after HSCT. We analyzed data for all patients who underwent allogeneic HSCT between the years of 2004-2014. After initial analysis, we excluded subjects who had diagnoses for which there were less than twenty patients. Univariate analysis was performed to identify risk factors for ARF requiring HD, 30-day mortality and 100-day mortality. Univariate association of categorical variables with outcomes and potential confounding variables was assessed using exact Chi-square tests. All variables associated with outcomes with p<0.2 were entered into a logistic regression model with the final model being selected using a backward elimination procedure until all variables had p<0.2. Results We analyzed 373 consecutive patients who underwent allogeneic HSCT at our institution between 2004 and 2014. After excluding diagnoses with less than twenty patients, we analyzed the remaining 332 patients. Median age was 54 years (range 19-78) and 42% of subjects were female. Diagnoses included acute myeloid leukemia (44.3 %), non-Hodgkin lymphoma (22.3%), acute lymphoid leukemia (14.8 %), myelodysplastic syndrome (MDS) (11.8%) and multiple myeloma (6.9%). Univariate associations between risk factors and three outcomes- renal failure requiring HD, 30-day mortality and 100-day mortality, were assessed. Within this set of 332 subjects, the incidence of renal failure requiring HD was 11.8%., 30-day mortality was 6.3%, and 100-day mortality was 16.6%. Creatinine >1.5 mg/dL at the time of HSCT was significantly associated with these outcomes. In addition, the diagnosis of MDS was associated with both 100-day mortality (p <0.001) and HD (p =0.0091). An increase in creatinine by 50% or greater between the time of admission and the day of HSCT was associated with need for HD (p =0.0026). Final logistic regression models show that candidate variables for predicting 30-day mortality were creatinine >1.5 mg/dL on the day of HSCT (p =0.045), use of amphotericin (p =0.052), and diagnosis of MDS (p =0.11). Candidate variables for predicting 100-day mortality were creatinine >1.5 mg/dL on the day of (p =0.023), diagnosis of MDS (p =0.035), and each one year increase in age (p =0.013). Candidate variables for renal failure requiring HD were creatinine >1.5 mg/dL on the day of HSCT (p <0.001) and a diagnosis of MDS (p =0.03). Creatinine at HSCT and diagnosis were included in all models. Discussion Although preexisting renal disease is incorporated into current models of risk at the time of transplant (e.g. HCT-CI), the specific risk for HD has not previously been quantified. Our analysis shows an 11.8% risk of ARF requiring HD following HSCT, with increased risk related to preexisting renal disease and underlying diagnosis of MDS. This suggests that patients should be counseled appropriately about this specific risk of renal failure requiring HD if the creatinine is >1.5 mg/dL. Similarly, patients with creatinine >1.5 mg/dL at time of HSCT are also at increased risk of 30-day and 100-day mortality compared to their counterparts with creatinine ≤1.5. Disclosures No relevant conflicts of interest to declare.

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Hurley, R. Morrison. "Enuresis: The Difference Between Night and Day." Pediatrics In Review 12, no. 6 (December 1, 1990): 167–70. http://dx.doi.org/10.1542/pir.12.6.167.

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The differentiation between night and day wetting allows the application of practical developmental and behavioral approaches to the diagnosis, evaluation, and therapy of each problem. Wetting the bed is mainly a developmental issue, and wetting the pants is a behavioral one.

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de Sousa, V. Teixeira, J. Marques, A. Martins, I. Domingues, R. Pedrosa, R. Curral, and A. Roma Torres. "Diagnostic Stability of Mood Disorders in a Psychiatry Day-hospital." European Psychiatry 24, S1 (January 2009): 1. http://dx.doi.org/10.1016/s0924-9338(09)70968-x.

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Mood disorders are common and account for one of the greatest causes of disability worldwide. Accordingly, those conditions are frequent among patients treated in Psychiatry Day-Hospitals facilities. Patients referred for treatment in Hospital de São João Day-Hospital have a previous variable period of follow-up in ambulatory clinic or hospitalization, commonly, with an established diagnosis. Notwithstanding, during the Day-Hospital stay, diagnosis may be reviewed because of new clinical data. Diagnostic stability over time is an important issue in clinical practice because it may influence treatment and, therefore, the final outcome. It is closely related with the contact between the patient and the healthcare system. Diagnostic instability is commonly due to fluctuation of disease manifestation over time or presence of co-morbid psychiatric illness in combination with rigid diagnostic criteria. The main objective of this study is to evaluate the diagnosis stability of Mood Disorders among patients treated in a Psychiatry Day-Hospital, applying ICD-10. The clinical sample includes patients admitted to Hospital de São João Psychiatry Day-Hospital whose main diagnosis is a Mood Disorder (F30-39), in the period between January 2005 and June 2008. Admission and delivery diagnosis were compared for each patient in this diagnostic category. Results suggest a high level of stability in this diagnostic group in the Day Hospital setting. For global conclusions about stability of Mood Disorders it would be interesting to replicate this study with larger samples and in different settings.

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Drevets, Peter, Jane M. Chung, Stephanie Schampaert, and Carsten Schroeder. "Hybrid Operating Room: One-Stop-Shop for Diagnosis, Staging, and Treatment." Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery 14, no. 5 (July 25, 2019): 463–67. http://dx.doi.org/10.1177/1556984519863800.

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The Hybrid Operating Room allows the thoracic surgeon to image, biopsy, diagnose, and operate in the same setting. With this streamlined model, time from referral to diagnosis to treatment is reduced. Increased efficiency allows for diagnosis and definitive surgical therapy sooner, thereby improving patient outcomes. A team-based approach is required for this one-stop-shop model of thoracic surgical practice to succeed. We present a series of prospective registry chart reviews demonstrating the utility of same-day diagnosis for thoracic oncology patient outcomes. Of the 21 patients presented, we were able to successfully obtain a diagnosis in 20 patients, resulting in a >95% single-session diagnostic rate.

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El Morshedy, H., A. Y. Shehab, A. Zaki, and H. F. Farag. "Intra-specimen and day-to-day variations of Fasciola egg counts in human stools." Eastern Mediterranean Health Journal 8, no. 4-5 (August 31, 2021): 619–25. http://dx.doi.org/10.26719/2002.8.4-5.619.

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Intra-specimen and day-to-day variations of Fasciola egg counts in stools were investigated for 16 cases of established fascioliasis. For each case six Kato slides from a single stool sample were examined daily for 5 consecutive days. The results indicated the presence of significant intra-specimen variations in more than one-third of the examined series, while the inter-specimen variation was almost negligible. The sensitivity of the Kato-Katz test for diagnosing Fasciola infection with three Kato slides from the same specimen or on different days ranged from 96.0%-99.1%. The examination of three Kato smears from a single stool specimen, which is more feasible in field studies, would give an accurate diagnosis of fascioliasis. Used as such, the Kato-Katz technique is highly sensitive in the diagnosis of fascioliasis

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Kalb, Rosalind. "Wellness for People Living with Multiple Sclerosis Begins on Day One—With Comprehensive, Coordinated Care that is Our Shared Responsibility." US Neurology 12, no. 02 (2016): 78. http://dx.doi.org/10.17925/usn.2016.12.02.78.

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Living well with multiple sclerosis (MS) requires the integration of neurologic and primary care, psychosocial support and wellness strategies from diagnosis onward. Promotion of healthy lifestyle behaviors and management of co-morbidities may help to improve quality of life, slow disease progression, reduce hospitalizations and prolong life. The National MS Society’s new Wellness Discussion Guide is available to facilitate conversations with patients as well as shared decision-making around wellness strategies.

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Singh, H., R. Sen, S. Singh, S. B. Siwach, Jagdish, and R. M. Singh. "Utility of Intradermal Smear in the Diagnosis of Malaria." Tropical Doctor 33, no. 2 (April 2003): 108–10. http://dx.doi.org/10.1177/004947550303300220.

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The objective of this preliminary study was to evaluate the usefulness of the intradermal smear test in the diagnosis of malaria. One hundred cases of suspected malaria (having received no prior antimalarials) were investigated. Both peripheral blood film (PBF) and intradermal smears (IDS) were simultaneously prepared and patients placed on antimalarial therapy. The slides were repeated for the next 2 days. At admission, 70 cases were positive on PBF −59 were Plasmodium falciparum (PF) and 11 were Plasmodium vivax (PV) whereas surprisingly 62 cases were positive on IDS at admission −61 were PF, one was PV. IDS identified two more cases of PF [ P value (not significant)] but failed to identify any new cases of PV ( P value NS). On subsequent days IDS positivity for PF was higher than for PBF ( P< 0.05 for day 1 and P < 0.001 for day 2). However, the PV yield was poor for any further statistical evaluation on subsequent days. We conclude that IDS is simple, easy to perform, requires no special infrastructure compared to PBF, and is a helpful diagnostic tool in cases where malaria is strongly suspected but peripheral blood slides are repeatedly negative due to prior use of antimalarial therapy. IDS may be added to routine PBF in malaria (especially PF).

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Yin, Zhihong, Wenbo Huang, Kapil Dev Singh, Zhaoming Chen, Xing Chen, Zhen Zhou, Zifeng Yang, Pablo Sinues, and Xue Li. "In vivo monitoring of volatile metabolic trajectories enables rapid diagnosis of influenza A infection." Chemical Communications 57, no. 39 (2021): 4791–94. http://dx.doi.org/10.1039/d1cc01061a.

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Demiroglu, Yusuf Ziya, Tuba Turunc Yeter, Can Boga, Hakan Ozdogu, Ebru Kizilkilic, Nebil Bal, Ilhan Tuncer, and Hande Arslan. "Bone Marrow Necrosis: A Rare Complication of Herbal Treatment with Hypericum Perforatum (St. John’s Wort)." Acta Medica (Hradec Kralove, Czech Republic) 48, no. 2 (2005): 91–94. http://dx.doi.org/10.14712/18059694.2018.38.

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A 22-year-old man presented with fever and ulceration of the oral mucosa. The patient had pharyngeal and esophageal candidiasis. For the 3 weeks prior to presentation, he had been taking approximately 1000 mg/day of flowering herbs (Hypericum perforatum L, known as St. John’s wort) for treatment of depression. A complete blood count on the first day of hospitalization showed agranulocytosis and normocytic anemia. His condition worsened, and he developed progressive dysphagia. A bone marrow biopsy on day 3 revealed bone marrow necrosis. After the diagnosis was established (day 3 of hospitalization), treatment with granulocyte colony-stimulating factor 48 U/day, intravenous immunoglobulin 400 mg/kg, and amphotericin B 100 mg/day was initiated. The patient did not respond, and died within one week of the diagnosis. This cases suggests that Hypericum species may lead to severe hematologic toxicity, with conditions involving bone marrow necrosis.

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Koffman, Jonathan, Naomi J. Fulop, David Pashley, and Ken Coleman. "Ethnicity and use of acute psychiatric beds: One-day survey in North and South Thames regions." British Journal of Psychiatry 171, no. 3 (September 1997): 238–41. http://dx.doi.org/10.1192/bjp.171.3.238.

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BackgroundPrevious studies have shown higher rates of psychiatric admissions, compulsory admissions, and diagnosed schizophrenia in Black ethnic groups compared with other population groups.MethodIn a point-prevalence study, demographic and clinical data were collected for adult acute and low-level secure psychiatric in-patients in all National Health Service and seven private psychiatric units in North and South Thames regions on 15 June 1994ResultsA total of 3710 adult acute and 268 low-level secure psychiatric patients were surveyed; 75% of the patients were White, 16% were Black, and 4% were Asian. Analysis reveals that a high proportion of the Black population were admitted to a psychiatric unit; that Black patients are more likely to be admitted under Section; to be located in locked wards; have an inpatient diagnosis of schizophrenia; and not be registered with a general practitioner.ConclusionsThese findings demonstrate the over-representation of Black ethnic groups within current psychiatric provision. The complement of services to all minority ethnic groups should be examined in terms of access, appropriateness and quality of care. Racism awareness and staff training need to be incorporated into mental health service provision as a matter of priority.

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Bajjad, Adeel Ahmed, Anil Sharma, Santosh Verma, and Sayantan Choudhury. "Management of Maxillary Buccal and Palatal Impacted Canines – Case Reports." Orthodontic Journal of Nepal 12, no. 1 (August 15, 2022): 55–60. http://dx.doi.org/10.3126/ojn.v12i1.47490.

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Maxillary impacted canine is one of the most common entity which a clinician encountered in day to day life. The management of impacted canines need precise diagnosis and careful application of biomechanics for optimum result. In this article 2 different case reports have been discussed which were treated with different mechanotherapy.

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Arbelo, N. "MALIGNANT CATATONIA IN MEDICAL WARDS: A BROAD DIFFERENTIAL DIAGNOSIS." European Psychiatry 66, S1 (March 2023): S771—S772. http://dx.doi.org/10.1192/j.eurpsy.2023.1626.

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IntroductionCatatonia is an uncommon and heterogeneous psychomotor syndrome. It can be not only the manifestation of a psychiatric disorder but also a wide range of medical conditions. The malignant catatonia is a subtype of catatonia which includes dysautonomic signs such as hyperthermia or hemodynamic instability, and because most of the affected patients are taking antipsychotics or antidepressants previously, it can be confounded with medical conditions such as neuroleptic or serotonin syndrome.ObjectivesTo present a case of malignant catatonia admitted in a medical wardMethodsThe present study is a case report of a patient admitted with initial diagnosis of serotonin syndrome in a medical ward of our hospital and referred to the consultation and liaison psychiatry (CLP) unit. We also searched previously case reports, series and systematic reviews about catatonia secondary to medical conditions and hyperthermia catatonia.ResultsMs. TN is a 71-year-old woman, with prior history of major depressive disorder. One month ago she was admitted in a psychiatric ward of another hospital for a depressive episode with psychotics features, and was treated with escitalopram 10mg/day, vortioxetine 10mg/day, mirtazapine 15mg/day, trazodone 50mg/day, quetiapine 700mg/day and haloperidol 5mg/day. She had a worsening of depressive symptoms with suicidal thoughts, negativism and psychomotor retardation, and subsequently hyperthermia, rigidity, mydriasis, tachicardia and increased bowel sound. She was tranfered to our medical ward, and diagnosed of serotonin syndrome. She was stopped all the psychiatric drugs and was treated with dantrolene and support measures. After 10 days without antidepressants or antipsychotics she maintened the same symptomatology and was referred to our CLP unit. The psychopathological evaluation showed stupor, mutism, waxy flexibility and negativism, and she responded to a challenge test with intravenous clonazepam 0,5mg. She was diagnosed of malignant catatonia and was started oral clonazepam 2mg/day. Although there was a partial response, she did not tolerate higher doses because of sedation and finally was treated with electroconvulsive therapy (ECT). She dad a remission of catatonic symptoms after only two sessions of ECT.ConclusionsMalignant catatonia can be confounded with other medical conditions such as serotonin or neuroleptic syndromes. All of them can have catatonic signs, and it is important to recognize them (a challenge test with a benzodiacepine can be helpful). The key to distingish malignant catatonia from them is that some of the catatonic signs (negativism and psychomotor retardation) happened before the dysautonomic signs. Also, it is uncommon that a serotonin syndrome persisted more than 3-5 days after the suspension of antidepressants. Consultation and liaison psychiatrists can help for the differential diagnosis and management of patients with suspected catatonia in medical wards.Disclosure of InterestNone Declared

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Hanh, N. V., Q. X. Huu, N. T. Uoc, B. X. Nguyen, J. Sulon, N. M. Sousa, and J. F. Beckers. "162 ESTRUS SYNCHRONIZATION, ARTIFICIAL INSEMINATION, AND PREGNANCY DIAGNOSIS IN WATER BUFFALOES (BUBALUS BUBALIS)." Reproduction, Fertility and Development 19, no. 1 (2007): 198. http://dx.doi.org/10.1071/rdv19n1ab162.

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One of the big obstacles in management of reproductive activity in water buffaloes is their silent estrus. This characteristic prevents the determination of time for artificial insemination (AI), resulting in lengthening of the calving interval (Nguyen et al. 1990 Proc. FAO Workshop, Bulgaria, 210–216). Pregnancy-associated glycoprotein (PAG) measurement in maternal blood is an effective method of early pregnancy diagnosis in ruminant species (Zoli et al. 1992 Biol. Reprod. 46, 83–92). The present study describes a preliminary attempt to improve buffalo reproductive performance by association of three different approaches: synchronization of estrus by hormonal treatment, followed by two AI, and finally pregnancy diagnosis based on PAG measurements. A total of 33 buffalo females (4 to 15 years old), with no apparent estrus during a period of 9 to 36 months after last calving, were used. Each female received 2 injections of 5 mL of PGF2α (Intervet, France) 10 days apart (Day −12 and Day −2), one injection of 500 IU of PMSG (SABC, Vietnam) at Day −5, and 1000 IU of hCG (Intervet, France) on the day of AI (Day 0). A second AI was performed 8 h after hCG injection. Blood samples (9 mL) were collected from each female at Days 20, 25, 40, and 45 after AI. Blood samples were withdrawn by jugular venipuncture (heparinized Vacutainer tubes) and kept in a cool box until centrifugation (500g, 10 min). Plasma samples were stored at −20°C until assayed for PAG. Pregnancy diagnosis was considered negative, doubtful, or positive according to the PAG concentrations (<0.6 ng mL−1, 0.6 to 0.8 ng mL−1, and >0.8 ng mL−1, respectively). Clinical observation of females after insemination showed that the total rate of animals that exhibited signs of estrus until Day 45 was 9.1% (3/33). These 3 females were not considered for pregnancy diagnosis. Table 1 shows the results of pregnancy diagnosis in 30 water buffalo females. These results show that fertilization is easily obtained after estrus synchronization in buffaloes and that measurement of PAG concentrations in maternal plasma can be used for pregnancy diagnosis from Day 40 after AI. Table 1.Number of water buffalo females considered as non-pregnant, doubtful or pregnant on the basis of PAG concentrations This work was supported by a grant from the Belgian Technical Cooperation.

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Thioub, Daouda, Ndeye Amy Sarr, Christine Amengo Kogwapa, Khardiata Diallo Mbaye, Ndeye Aïssatou Lakhe, Aboubakar Sidikh Badiane, Daye Ka, Ndeye Maguette Fall, Viviane Marie Pierre Cisse, and Moussa Seydi. "Pulmonary Involvement during Varicella in a Patient with Sickle Cell Disease: Diagnosis and Treatment." Asian Journal of Research in Infectious Diseases 15, no. 2 (February 28, 2024): 31–36. http://dx.doi.org/10.9734/ajrid/2024/v15i2329.

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Introduction: Pulmonary involvement during chickenpox is one of the most serious complications. However, it can be difficult to distinguish between varicella pneumonia, bacterial superinfection and an acute chest syndrome. We report a case of varicella complicated by pneumonia in a young adult with sickle cell disease. Observation: It was a 24-year-old woman with sickle cell disease. Examination on admission revealed generalized skin lesions of varying ages, associated with scratching lesions. On day 3 of hospitalization, she presented an acute respiratory distress associated with fever (40°C). Thoracic CT angiography revealed diffuse pulmonary nodules and micronodules in both lung fields. Blood culture isolated Staphylococcus spp. The patient was put on oxygen therapy combined with antiviral treatment and antibiotic therapy. The course was marked by symptoms regression, with disappearance of respiratory distress on day 2 and apyrexia on day 3 of treatment. The follow-up chest CT scan carried out at month 4, came back normal. Conclusion: Although pneumonia is one of the most common complications of varicella, it can be difficult to diagnose in patients with sickle cell disease, considering the frequency of pulmonary involvement of various etiologies

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Armstrong, Heather, and Katie Koehler. "What happens now? A post-diagnosis workshop for parents of children with Asperger’s syndrome/high functioning autism." Clinical Psychology Forum 1, no. 195 (March 2009): 19–22. http://dx.doi.org/10.53841/bpscpf.2009.1.195.19.

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Martinez-Subiela, S., and Ceron JJ. "Evaluation of acute phase protein indexes in dogs with leishmaniasis at diagnosis, during and after short-term treatment." Veterinární Medicína 50, No. 1 (March 27, 2012): 39–46. http://dx.doi.org/10.17221/5595-vetmed.

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An acute phase index based on a combination of acute phase proteins which permitted monitoring the response to therapy of canine leishmaniasis was developed and evaluated in this study. Six dogs naturally infected by Leishmania infantum were treated with meglumine antimoniate (Glucantime<sup></sup>, Merial, Lyon, France) 100 mg/kg/day sc, given concurrently for 20 days with allopurinol (Zyloric®, Glaxo Wellcome, Madrid, Spain) 30 mg/kg/day po and then, allopurinol alone for one month at the same dosage. Blood samples for acute phase proteins were obtained on different days before and after the beginning of treatment and two groups of indexes were calculated: (1) Indexes that combined one positive and one negative acute phase protein and (2) Indexes that combined two positive and one negative acute phase proteins. All calculated indexes were significantly higher in animals with leishmaniasis compared with clinically healthy dogs (n = 8) and a decrease was observed in all dogs tested during the treatment. Indexes that combined C-reactive protein (CRP) and ceruloplasmin (CP) with other proteins showed greater percentages of decrease that were statistically significant. Among these, the index CRP*CP/Alb was selected as the optimum since it showed a larger and faster decrease compared with the others as well as with individual proteins alone. These results would support the use of selected acute phase indexes, especially the CRP*CP/Alb index, to suspect about a leishmaniotic dogs and to monitor their response to treatment.

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Speckhart, Dawn, Scott R. Solomon, Asad Bashey, Lawrence Morris JR, Tina Berry, and H. Kent Holland. "The Impact of a Pre-Existing Psychiatric Diagnoses on a Newly Diagnosed Acute Leukemia Patient's Emotional Functioning During Induction Chemotherapy as Measured by the Brief Symptom Inventory-18 (BSI-18)." Blood 116, no. 21 (November 19, 2010): 1505. http://dx.doi.org/10.1182/blood.v116.21.1505.1505.

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Abstract Abstract 1505 The psychological distress patients feel when diagnosed with acute leukemia is often devastating and overwhelming. For those already struggling with depression, anxiety or other psychiatric symptoms, it is hypothesized that the addition of a diagnosis of acute leukemia would exacerbate the psychiatric symptoms already present. Anecdotal case reports have shown that upon being diagnosed with cancer, typically the first hours to first several days, patients are overwhelmed and unable to process all of the information being given to them by the oncology physician/team. In the case of acute leukemia patients, there is the additional layer of distress due to an urgency to start treatment within days of diagnosis. In this study, psychological data was prospectively collected on 40 patients newly diagnosed with acute leukemia. Each patient was assessed for pre-existing psychiatric diagnosis based on DSM-IV criteria. Patients were placed into one of two groups: psychiatric diagnosis prior to acute leukemia (n=22) or no psychiatric diagnosis prior to acute leukemia (n=18). Each patient completed the Brief Symptom Inventory -18 (BSI-18) at Days 1, 7 and 21 during their induction chemotherapy for acute leukemia. There were no significant differences in gender, age, or disease (AML vs. ALL) between the two groups. The BSI-18 has a Global Stress Index (GSI) score and subscale scores, including Anxiety and Depression. Patients with psychiatric diagnoses prior to having acute leukemia had significantly higher GSI scores at Days 1 (p=.005) and 7 (p=.02) as compared to those patients who did not have a psychiatric diagnosis. This trend was the same when looking at the Anxiety subscale which also found a significant difference between groups, with the patients having psychiatric diagnoses reporting significantly more anxiety at Days 1 (p=.003) and 7 (p=.02). With regard to symptoms of Depression, patients with pre-existing psychiatric diagnoses reported significantly more symptoms of depression at Day 7 (p=.009) as compared to those patients without a psychiatric diagnosis. By Day 21, there was no significant difference in GSI, Anxiety or Depression between groups. During the induction chemotherapy, all patients were evaluated by the program's Health Psychologist within 72 hours of admission to the leukemia unit and psychological follow-up during their chemotherapy treatment. All 40 patients remained hospitalized from Day 1 of chemotherapy until count recovery. The data indicates that those patients with pre-existing psychiatric diagnoses have significantly more difficulty coping during the first week of their induction chemotherapy for acute leukemia. However, by the time patients have been in treatment for 21 days, all patients appear to be coping moderately well with no objective evidence of clinical depression or anxiety. One may conclude that although psychosocial factors impact a patient's ability to cope with a major stressor, such as being diagnosed with acute leukemia, these differences are most apparent immediately following diagnosis. It appears that in time, both groups of patients appear to be able to deal with the emotional distress related to the diagnosis of acute leukemia. Additionally, it would appear that patients with a history of psychiatric diagnoses might require more psychosocial support during the early days of treatment. Further research is needed to identify what factors (time, education, family support, health psychology services, etc…) are most useful in assisting these psychiatric patients with their psychological distress. Disclosures: No relevant conflicts of interest to declare.

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Turhan, İpek, and Kübra Akcan. "Current Diagnosis and Treatments of Female Sexual Dysfunction." Gevher Nesibe Journal IESDR 7, no. 17 (March 21, 2022): 57–63. http://dx.doi.org/10.46648/gnj.384.

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Sexual health is an important part of health. The definition of sexual health is one of the basic rights of all people, men, women, young and old, which includes being in complete physical and emotional well-being, as in the definition of health. Sexual dysfunctions are problems that occur due to psychophysiological changes in the sexual response cycle and sexual desire. Although sexual dysfunctions vary according to societies, they are frequently seen problems that reduce the quality of life of the individual and force the individual. Although the incidence of sexual dysfunctions is increasing day by day, it is an important health problem that is little known and less intervened by health professionals. Sexuality has been recognized as an important and integral part of nursing by organizations covered by the American Nursing Association (ANA). The North American Nursing Diagnosis Association added the diagnosis of sexual dysfunction to the list of nursing diagnoses in 1980. Sexuality is an issue that is considered taboo in our country as well as in most societies and is ignored by health professionals. Sexual dysfunction in women is affected by many factors, and sexual dysfunction in women causes lack of self-confidence, emotional stress and deterioration in personal relationships. Sexual problems are affected by biological and psychological factors. Therefore, they must be considered together. In this review, the current diagnosis and treatment of sexual dysfunctions in women are discussed.

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