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Статті в журналах з теми "On-Demand release"
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Field, Rachel D., Margaret A. Jakus, Xiaoyu Chen, Kelia A. Human, Xuanhe Zhao, Parag V. Chitnis, and Samuel K. Sia. "Ultrasound-responsive hydrogel microcapsules for on-demand drug release." Journal of the Acoustical Society of America 154, no. 4_supplement (October 1, 2023): A279. http://dx.doi.org/10.1121/10.0023522.
Повний текст джерелаАнотація:
Hydrogel-based implantable systems offer viable solutions for localized drug delivery but often lack the ability to easily achieve on-demand actuation or real-time tuning of release kinetics in response to physiological changes. Here, we present a hydrogel microcapsules produced using two-phase microfluidics that can release drugs on demand as triggered by focused ultrasound (FUS). The biphasic microcapsules consist of an outer phase of mixed molecular weight (MW) poly(ethylene glycol) diacrylate that mitigates premature payload release and an inner phase of high MW dextran with payload that breaks down in response to FUS. Compound release from microcapsules could be triggered as desired; 0.4 μg of payload was released across 16 on-demand steps over days. We detected broadband acoustic signals amidst low heating, suggesting inertial cavitation as a key mechanism for payload release. Overall, FUS-responsive microcapsules are a biocompatible and wirelessly triggerable structure for on-demand drug delivery over days to weeks.
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Wood, Jonathan. "Coatings release corrosion inhibitors on demand." Materials Today 8, no. 10 (October 2005): 10. http://dx.doi.org/10.1016/s1369-7021(05)71113-5.
Повний текст джерела
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Vakil, Anand Utpal, Maryam Ramezani, and Mary Beth B. Monroe. "Magnetically Actuated Shape Memory Polymers for On-Demand Drug Delivery." Materials 15, no. 20 (October 18, 2022): 7279. http://dx.doi.org/10.3390/ma15207279.
Повний текст джерелаАнотація:
Repeated use of intravenous infusions to deliver drugs can cause nerve damage, pain, and infection. There is an unmet need for a drug delivery method that administers drugs on demand for prolonged use. Here, we developed magnetically responsive shape memory polymers (SMPs) to enhance control over drug release. Iron oxide magnetic nanoparticles (mnps) were synthesized and incorporated into previously developed SMPs to enable magnetically induced shape memory effects that can be activated remotely via the application of an alternating magnetic field. These materials were tested for their shape memory properties (dynamic mechanical analysis), cytocompatibility (3T3 fibroblast viability), and tunable drug delivery rates (UV–VIS to evaluate the release of incorporated doxorubicin, 6-mercaptopurine, and/or rhodamine). All polymer composites had >75% cytocompatibility over 72 h. Altering the polymer chemistry and mnp content provided methods to tune drug release. Namely, linear polymers with higher mnp content had faster drug release. Highly cross-linked polymer networks with lower mnp content slowed drug release. Shape memory properties and polymer/drug interactions provided additional variables to tune drug delivery rates. Polymers that were fixed in a strained secondary shape had a slower release rate compared with unstrained polymers, and hydrophobic drugs were released more slowly than hydrophilic drugs. Using these design principles, a single material with gradient chemistry and dual drug loading was synthesized, which provided a unique mechanism to deliver two drugs from a single scaffold with distinct delivery profiles. This system could be employed in future work to provide controlled release of selected drug combinations with enhanced control over release as compared with previous approaches.
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Singh, Baljinder, Kibeom Kim, and Myoung-Hwan Park. "On-Demand Drug Delivery Systems Using Nanofibers." Nanomaterials 11, no. 12 (December 16, 2021): 3411. http://dx.doi.org/10.3390/nano11123411.
Повний текст джерелаАнотація:
On-demand drug-delivery systems using nanofibers are extensively applicable for customized drug release based on target location and timing to achieve the desired therapeutic effects. A nanofiber formulation is typically created for a certain medication and changing the drug may have a significant impact on the release kinetics from the same delivery system. Nanofibers have several distinguishing features and properties, including the ease with which they may be manufactured, the variety of materials appropriate for processing into fibers, a large surface area, and a complex pore structure. Nanofibers with effective drug-loading capabilities, controllable release, and high stability have gained the interest of researchers owing to their potential applications in on-demand drug delivery systems. Based on their composition and drug-release characteristics, we review the numerous types of nanofibers from the most recent accessible studies. Nanofibers are classified based on their mechanism of drug release, as well as their structure and content. To achieve controlled drug release, a suitable polymer, large surface-to-volume ratio, and high porosity of the nanofiber mesh are necessary. The properties of nanofibers for modified drug release are categorized here as protracted, stimulus-activated, and biphasic. Swellable or degradable polymers are commonly utilized to alter drug release. In addition to the polymer used, the process and ambient conditions can have considerable impacts on the release characteristics of the nanofibers. The formulation of nanofibers is highly complicated and depends on many variables; nevertheless, numerous options are available to accomplish the desired nanofiber drug-release characteristics.
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Gupta, R. K., F. Mirza, M. U. F. Khan, and J. Esquivel. "Aluminum containing Na2CrO4: Inhibitor release on demand." Materials Letters 205 (October 2017): 194–97. http://dx.doi.org/10.1016/j.matlet.2017.06.080.
Повний текст джерела
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Wang, Joseph. "On-Demand Electrochemical Release of Nucleic Acids." Electroanalysis 13, no. 8-9 (May 2001): 635–38. http://dx.doi.org/10.1002/1521-4109(200105)13:8/9<635::aid-elan635>3.0.co;2-j.
Повний текст джерела
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Chen, Menglin, Yan-Fang Li, and Flemming Besenbacher. "Electrospun Nanofibers-Mediated On-Demand Drug Release." Advanced Healthcare Materials 3, no. 11 (May 30, 2014): 1721–32. http://dx.doi.org/10.1002/adhm.201400166.
Повний текст джерела
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Fallahi, Hedieh, Haotian Cha, Hossein Adelnia, Yuchen Dai, Hang Thu Ta, Sharda Yadav, Jun Zhang, and Nam-Trung Nguyen. "On-demand deterministic release of particles and cells using stretchable microfluidics." Nanoscale Horizons 7, no. 4 (2022): 414–24. http://dx.doi.org/10.1039/d1nh00679g.
Повний текст джерелаАнотація:
This paper reports a stretchable microfluidic cell trapper for the on-demand release of particles and cells in a deterministic manner. The size of particles to be trapped and released can be tuned by stretching the device.
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Eslami, Parisa, Martin Albino, Francesca Scavone, Federica Chiellini, Andrea Morelli, Giovanni Baldi, Laura Cappiello, et al. "Smart Magnetic Nanocarriers for Multi-Stimuli On-Demand Drug Delivery." Nanomaterials 12, no. 3 (January 18, 2022): 303. http://dx.doi.org/10.3390/nano12030303.
Повний текст джерелаАнотація:
In this study, we report the realization of drug-loaded smart magnetic nanocarriers constituted by superparamagnetic iron oxide nanoparticles encapsulated in a dual pH- and temperature-responsive poly (N-vinylcaprolactam-co-acrylic acid) copolymer to achieve highly controlled drug release and localized magnetic hyperthermia. The magnetic core was constituted by flower-like magnetite nanoparticles with a size of 16.4 nm prepared by the polyol approach, with good saturation magnetization and a high specific absorption rate. The core was encapsulated in poly (N-vinylcaprolactam-co-acrylic acid) obtaining magnetic nanocarriers that revealed reversible hydration/dehydration transition at the acidic condition and/or at temperatures above physiological body temperature, which can be triggered by magnetic hyperthermia. The efficacy of the system was proved by loading doxorubicin with very high encapsulation efficiency (>96.0%) at neutral pH. The double pH- and temperature-responsive nature of the magnetic nanocarriers facilitated a burst, almost complete release of the drug at acidic pH under hyperthermia conditions, while a negligible amount of doxorubicin was released at physiological body temperature at neutral pH, confirming that in addition to pH variation, drug release can be improved by hyperthermia treatment. These results suggest this multi-stimuli-sensitive nanoplatform is a promising candidate for remote-controlled drug release in combination with magnetic hyperthermia for cancer treatment.
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Onuora, Sarah. "Implanted ‘smart’ cells release biologic drugs on demand." Nature Reviews Rheumatology 17, no. 11 (September 29, 2021): 643. http://dx.doi.org/10.1038/s41584-021-00705-z.
Повний текст джерелаДисертації з теми "On-Demand release"
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Anderson, Stacey N. "Carbon Monoxide on Demand: Light-Induced CO Release of Flavonols." DigitalCommons@USU, 2018. https://digitalcommons.usu.edu/etd/7388.
Повний текст джерелаАнотація:
Carbon monoxide (CO) is an extremely useful molecule with applications in industrial manufacturing, synthetic procedures as a C1 building block, and as a potential pharmaceutical to produce anti-inflammatory effects and vasodilation. However, the toxicity associated with CO has prevented its full utilization. In order to safely handle CO, compounds and molecules have been developed that act as storage materials for the gas. Ideal storage platforms only release CO upon stimulation via a trigger. Light activation is the most desirable trigger as it can be regulated in terms of the intensity and the wavelength of light used. The majority of light-induced CO-storage platforms that have been reported to date consist of metal carbonyl compounds where CO is bound directly to a metal center. However, disadvantages inherent to this motif, such as potential toxicity associated with the metal and lack of characterization of CO release remnant(s), has pushed the research community to search for alternative CO storage structures.
The research presented in this dissertation outlines our approach toward the development of safe-to-handle, light-induced CO release platforms. We use a flavonol structure similar to those found in fruits and vegetables, such as quercetin, as a light-induced CO release unit. Through changes in the structure of the flavonol and its surrounding environment in chemical compounds, we have found ways to strategically control the light-induced CO release reactivity of the flavonol. Chemical compounds developed in this project are of interest for studying the effects of CO in biological systems and applications in synthetic processes.
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Sinha, Piyush M. "Nanoengineered implantable devices for controlled drug delivery." The Ohio State University, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=osu1115138930.
Повний текст джерела
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Kovacik, P., M. Soltys, and F. Stepanek. "Core-shell Structured Composite Silica Micro- and Nanoparticles with Ability Release a De fined Quantity „on Demand“." Thesis, Sumy State University, 2013. http://essuir.sumdu.edu.ua/handle/123456789/35571.
Повний текст джерелаАнотація:
The aim of this work was the preparation of biocompatible micro- and nanoparticles with a hollow in-terrior. The particles must be able to encapsulate and store a chemical payload for a certain time, followed by the release on demand of this payload. In our previous work [13] we have prepared silica microparticles with a hollow core and found that the diffusion across the mesoporous silica shell was strongly dependent on temperature. In this work, we used this dependence and attached iron oxide nanoparticles on the sur-face of the silica shell to create composite iron oxide/silica particles. The iron oxide nanoparticles were able to heat up in the presence of an alternating magnetic field. This property allowed us to use magnetic field as a tool for remote control of diffusion across the particle shell. To avoid spontaneous leakage of encapsu-lated payload in time, we have modified the surface of the composite micropaticles with a layer of palm oil. Palm oil is a phase change material which is solid under 37 °C. We showed that the resultant composite particles are able to store a payload for several months and release a defined quantity on demand by the application of a magnetic field. The particles were characterised in shape, size, heating ability and their mass transport properties.
When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/35571
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Chiu, Stanley Kai Him. "A hybrid P2P pre-release distribution framework for flash crowd avoidance in P2P video on demand streaming." Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/4067.
Повний текст джерелаАнотація:
In recent years, the high maintenance cost of centralized video on demand sys
tems has led to the development of peer to peer video on demand systems.
These peer to peer systems help to remove the cost and bandwidth limitations
of a centralized group of servers. In a peer to peer scenario, the publisher and a
small set of peers who were published to must handle all video requests. If many
peers request a video after it is released, the small set of peers with the video
cached may not have enough bandwidth to satisfy all requests. This situation
is known as a flash crowd. We propose a hybrid peer to peer framework that
allows publishers to publish videos before release time. For marketing purposes,
it is common for videos that are ready for distribution to be kept from being
released until a preset release time. By distributing a video before the release
time, more peers will have the video at release time, thus allowing more requests
to be handled. A hybrid peer to peer encryption management system is used
to prevent users from viewing videos before release time. In order to determine
who to distribute a video to before users are allowed to view the video, we design
a hybrid peer to peer subscription system. In this system, users may specify
interest in sets of videos and are notified of new videos matching the interest
so that retrieval may start. Finally, we modify an existing peer to peer video
on demand framework to better handle concurrent streaming and downloading.
Our experiments show that this framework can greatly increase a peer to peer
streaming system’s ability to handle flash crowd situations.
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Sanchez, Velasquez Camilo. "Conception rationnelle d'un revêtement antimicrobien contrôlable basé sur des réseaux de nanofils d'argent : Une étude combinée de la science des matériaux et du marketing." Electronic Thesis or Diss., Université Grenoble Alpes, 2024. http://www.theses.fr/2024GRALI040.
Повний текст джерелаАнотація:
Les revêtements antimicrobiens à libération ont fait l'objet de recherches intensives en raison de leur potentiel à prévenir les infections bactériennes via les surfaces contaminées. Cependant, en raison de leur profil de libération incontrôlée des charges antimicrobiennes, leur action peut entraîner une toxicité systémique dans les cellules humaines et dans l'environnement, ainsi qu'un épuisement rapide des composés antimicrobiens pré-chargés jusqu'à ce que les quantités libérées tombent en dessous des concentrations bactériennes sous-inhibitrices, se traduisant par une faible activité biocide au fil du temps. Ces limitations entravent leur application généralisée et soulignent le besoin de stratégies d'ingénierie pour développer de nouveaux revêtements antimicrobiens incorporant des systèmes de libération contrôlables. Une façon de remédier à ces lacunes est le développement de systèmes de libération déclenchés à la demande. Ces plateformes intègrent un matériau sensible au stimulus qui subit des changements morphologiques en réponse à un stimulus, permettant une libération ultérieure contrôlable des charges antimicrobiennes.Cette étude se concentre principalement sur le développement d'un design rationnel, complet et étape par étape, d'une plateforme de libération d'argent à la demande déclenchée par le chauffage Joule, basée sur des réseaux de nanofils d'argent (AgNW) revêtus. Nous présentons, pour la première fois, l'utilisation de ce type de systèmes comme matériaux sensibles aux stimuli, exploitant les voies de dégradation du réseau via la diffusion des atomes d'argent depuis la surface du nanofil lorsqu'il est soumis à des contraintes électriques ou thermiques. Ici, la libération d'argent induite par le chauffage Joule sert d'agent antimicrobien pour une activité antimicrobienne contrôlée à la demande. De plus, nous proposons l'utilisation d'une architecture multicouche comme design configurationnel pour les revêtements antimicrobiens à base de AgNW dans le but de fabriquer une plateforme antimicrobienne multifonctionnelle. Cette architecture permet l'incorporation d'un déclencheur de libération thermique et de capacités de stockage dans une plateforme unifiée tout-en-un. Une première démonstration du concept est présentée où un réseau stable de AgNW est utilisé comme élément chauffant, et un réseau de AgNW sacrificiel sert de réservoir d'atomes d'argent.Cependant, bien que les avancées actuelles en nanotechnologie ouvrent de nouvelles opportunités pour l'ingénierie de nouvelles plates-formes antimicrobiennes visant à prévenir et à inhiber la croissance des bactéries, les applications basées sur la nanotechnologie sont souvent perçues par les consommateurs comme risquées pour la santé et associées à des taux élevés d'incertitude, ce qui entrave leur acceptation et leur adoption. Les préoccupations concernant un usage non contrôlé peuvent entraîner des représentations mentales négatives et des associations chez les utilisateurs, influençant ainsi leur réponse à cette technologie. Par conséquent, il est nécessaire de mieux comprendre le processus de prise de décision des consommateurs et le traitement de l'information individuelle concernant les applications antimicrobiennes basées sur les nanomatériaux.Sur cette base, afin de comprendre en profondeur les intentions comportementales des individus à l'égard des innovations basées sur la nanotechnologie intégrant des fonctionnalités antimicrobiennes, qu'elles soient contrôlables ou non, ce travail développe un cadre conceptuel original et complet basé sur le Modèle d'Acceptation de la Technologie (TAM), mais intégrant des considérations plus holistiques et cognitives. À travers ce modèle multifacette, l'étude vise à éclairer les interactions de l'activité mentale individuelle, en termes d'imagerie mentale et d'associations mémorielles, et des principales variables de l'acceptation de la technologie selon le TAM (utilité perçue et facilité d'utilisation perçue)Release-based antimicrobial coatings have been intensively investigated due to their potential to prevent bacterial infections via contaminated surfaces. However, owing to their uncontrollable burst release profile of antimicrobial payloads, their action may cause systemic toxicity in human cells and the environment, as well as rapid depletion of the antimicrobial pre-loaded compounds until the released quantities drop below bacterial sub-inhibitory concentrations, translating into poor biocidal activity over time. These limitations hinder their widespread application and emphasize the need for engineering strategies to develop novel antimicrobial coatings that incorporate controllable release systems. One way to address these shortcomings is with the development of on-demand triggered release systems. These platforms incorporate a stimulus-responsive material that undergoes morphological changes in response to specific stimuli allowing subsequent controllable release of antimicrobial payloads.This study primarily focuses on developing a comprehensive, step-by-step, rational design of a Joule-heating-triggered on-demand silver release platform based on coated silver nanowire (AgNW) networks. We present, for the first time, the use of these sorts of systems as stimuli-responsive materials, taking advantage of the network degradation pathways via silver atom diffusion from the nanowire surface when subjected to electrical or thermal stress. Here, the release of silver induced by Joule heating serves as an antimicrobial agent for on-demand controlled antimicrobial activity. In addition, we propose the use of a multilayer architecture as a configurational design for AgNW-based antimicrobial coatings with the aim of fabricating a multifunctional antimicrobial platform. This architecture enables the incorporation of a heat-based release trigger and storage capabilities within a unified all-in-one platform. A first demonstration of the concept is presented where a stable AgNW network is used as a heater element, and a sacrificial AgNW network serves as an Ag atom reservoir.Nevertheless, although current advances in nanotechnology open up new opportunities for engineering novel antimicrobial platforms aimed at preventing and inhibiting bacteria growth, nanotechnology-based applications are often perceived by consumers as risky for health and associated with high rates of uncertainty, hindering acceptance and adoption. Concerns about uncontrolled use may lead to negative mental representations and associations among users, shaping their response to such technology. Therefore, there is a need for a deeper understanding of the consumer decision-making process and individual information processing toward nanomaterials-based antimicrobial applications.On this basis, in order to get an in-depth understanding of individuals' behavioural intentions towards nanotechnology-based innovations integrating antimicrobial features, either controllable or not controllable, this work develops an original and comprehensive conceptual framework based on the Technology Acceptance Model (TAM), but integrating more holistic and cognitive considerations and variables. Through this multifaceted model, the study aims to elucidate insight about the interplay of individual mental activity, in terms of mental imagery and memory associations, and the main variables of technology acceptance from TAM (perceived usefulness and perceived ease of use)
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Kuan-WenWang and 王冠雯. "Near-Infrared Sensitive Microneedles for On-demand Controlled Release." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/84349717607950745490.
Повний текст джерелаАнотація:
碩士國立成功大學
化學工程學系碩博士班
100
Microneedle (MN) patches, combining the advantages of hypodermic needles and transdermal patches, have been proposed as a new tool for transdermal drug delivery, because of their efficient delivery and lack of pain. Drug release from current available polymeric microneedles mostly depends on the physical properties of polymer; however, little work involves microneedles which can provide “on demand” drug delivery. In this study, a polymeric microneedle patch, which is consisted of biodegradable polymer and photothermal nanoparticles, silica-coated lanthanum hexaboride nanoparticles (LaB6@SiO2 NPs), using near-infrared (NIR) light as a trigger for drug release was reported as a novel transdermal drug delivery device. The skin insertion tests showed that the developed polymeric microneedles were strong enough to insert into the epidermis layer (~150 m) of porcine cadaver skin. After encapsulating LaB6@SiO2 NPs within MNs, the resulting microneedles were shown to have NIR-sensitive property and melt by stimulation with NIR light due to the local heating of the NPs. In vitro triggered release study showed that the drug release from the microneedles can be easily and non-invasively controlled by the adjustment of the irradiation time and frequency of NIR light. The continuous irradiation test demonstrated the encapsulated drugs can be released from the melted microneedles, and the amount of released drug was increased with increasing the irradiation time. The intermittent irradiation test demonstrated the melting of NIR-sensitive MNs exhibit reversible and repeatable heating when exposed to NIR light, and the drug release occurred in a stepwise fashion, where LASER ON induced a steep increase in drug release, and LASER OFF permitted only very little drug from being released over a long period. The animal study demonstrated the feasibility of the NIR-sensitive MNs for in vivo applications. It is expected that the NIR-sensitive microneedles may provide a simple and convenient technology for transdermal delivery of heat-stable drugs (such as DNA vaccine, or anti-cancer drugs etc.) and facilitate the development of drug delivery system.
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Yi, Yen-Tsai, and 易延才. "Programmable On-Demand Drug Release Device：An Electro-stimulated Approach." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/74315425608828124991.
Повний текст джерелаАнотація:
碩士國立臺灣大學
化學工程學研究所
100
Drug therapy efficacy depends on therapeutic concentrations of drugs at disease sites. An ideal controlled drug delivery device should safely contain a large quantity of drugs, release little or no drug in the “off ” state, be repeatedly switchable to the “on” state without mechanically disrupting the device, and can actively control release rates. In this thesis, an electro-stimulated membrane-based drug delivery device was developed to release drugs on demand. Drugs over a broad range of molecular weights (300-40000 Da) and different charge properties can be delivered by the same drug delivery approach. Ionic drug molecules were electrically ejected from polyelectrolyte hydrogels into bulk solution in vitro, the response time between electric stimulus and release amounts was fast, and without mechanically disrupting the membrane-based drug delivery device .We showed that the dose of drug delivered across drug delivery device could be tuned by different material of membrane, the strength of applied voltage, and the waveform of applied voltage, allowing for pulsatile drug delivery system of model drug, we could control the release rate at 1 order of magnitude (100~1000 ng / hr) during release processes. The system reported here has great potential for use in biomaterials, tissue engineering, implant technology, and biosensors for biomedical applications.
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Chen, Pei-Ying, and 陳佩瑩. "Development of Magnetically-targeted Drug Carriers for On-demand NIR-triggered Drug Release." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/65877063051141724347.
Повний текст джерелаАнотація:
碩士國立清華大學
生醫工程與環境科學系
103
An ideal carrier for chemotherapeutics delivery shall contain features such as cancer cell-targeting capability, low cytotoxicity and efficient killing effect on multiple drug resistant cancer cells. In this study, we proposed a novel nano-sized drug delivery system combining the advantages of: (1) NIR-triggered drug release; (2) magnetically-targeting and (3) magnetic resonance imaging (MRI) contrast. The drug carrier is mainly composed of poly-lactic-co-glycolic acid (PLGA), which is a highly biocompatible, biodegradable and US Food and Drug Administration (FDA)-approved materials for clinical uses. PLGA is widely used for drug delivery applications due to its advantages on protecting drug from loss of activity, reducing drug-associated cytotoxicity and improving drug stability. By utilizing single emulsion method, we have successfully encapsulated doxorubicin (a chemotherapeutic drug), superparamagnetic iron oxide nanoparticles (SPIONs) and gold nanorods (Au NRs) within the hydrophobic core of PLGA nanoparticles (NP). The size and surface potential of the resultant AFP were approximately 200 nm and -24 mV respectively. The prepared DOX@SPIONs/Au NRs/ PLGA nanoparticle(DOX@SAPP)were successfully verified with the following features, including: (1) Hydrophilic nanoparticle surface: the DOX@SAPP were covered with hydrophilic polyethylene glycol (PEG), which helps maintaining particle stability and may extend its in vivo circulation time. (2) Capability of loading of various theranostic materials: The loading contents for doxorubicin, SPIONs were 3.77% and 5.8% respectively. By tuning the feeding amount of dodecane-Au NRs (O.D. value 33, 100 and 300), PLGA nanoparticles with different Au NRs loading content (1.31%, 2.73% and 8.19%) can be prepared. (3) Well colloidal stability: the prepared DOX@SAPP were stable up to 3 days in various mediums such as: water, PBS and 25% FBS DMEM medium. The size of DOX@SAPP was not changed significantly in PBS for 15 days. (4) Magnetically-assisted drug delivery and MRI contrast: the DOX@SAPP exhibits superparamagnetism with the saturation magnetization of 3.04 emu/g. The cellular uptake of DOX@SAPP was greatly enhanced by the presence of external magnetic field. Cell-number dependent T2-weighing MRI was demonstrated from the DOX@SAPP -uptake cancer cells. The DOX@SAPP enters cells via endocytosis which can avoid the “drug pumping out” effect by multiple drug resistant cancer cells. Under the irradiation of NIR, the Au NRs-mediated photothermal effect effectively triggered rapid drug release from DOX@SAPP Finally, the combined photothermal- and chemo- therapeutic effect was successfully demonstrated on astrocytoma tumor cell line (ALTS1C1), human breast cancer cells (MCF7) and its multiple drug resistant strain (ADR-MCF7).
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Pitto-Barry, Anaïs, A. Lupan, C. Ellingford, A. A. A. Attia, and Nicolas P. E. Barry. "New class of hybrid materials for detection, capture, and "on-demand" release of carbon monoxide." 2018. http://hdl.handle.net/10454/15942.
Повний текст джерелаАнотація:
YesCarbon monoxide (CO) is both a substance hazardous to health and a side product of a number of industrial processes, such as methanol steam reforming and large-scale oxidation reactions. The separation of CO from nitrogen (N2) in industrial processes is considered to be difficult because of the similarities of their electronic structures, sizes, and physicochemical properties (e.g., boiling points). Carbon monoxide is also a major poison in fuel cells because of its adsorption onto the active sites of the catalysts. It is therefore of the utmost economic importance to discover new materials that enable effective CO capture and release under mild conditions. However, methods to specifically absorb and easily release CO in the presence of contaminants, such as water, nitrogen, carbon dioxide, and oxygen, at ambient temperature are not available. Here, we report the simple and versatile fabrication of a new class of hybrid materials that allows capture and release of carbon monoxide under mild conditions. We found that carborane-containing metal complexes encapsulated in networks made of poly(dimethylsiloxane) react with CO, even when immersed in water, leading to dramatic color and infrared signature changes. Furthermore, we found that the CO can be easily released from the materials by simply dipping the networks into an organic solvent for less than 1 min, at ambient temperature and pressure, which not only offers a straightforward recycling method, but also a new method for the “on-demand” release of carbon monoxide. We illustrated the utilization of the on-demand release of CO from the networks by carrying out a carbonylation reaction on an electron-deficient metal complex that led to the formation of the CO-adduct, with concomitant recycling of the gel. We anticipate that our sponge-like materials and scalable methodology will open up new avenues for the storage, transport, and controlled release of CO, the silent killer and a major industrial poison.
The Royal Society, The Romanian Ministry of Education and Research, The University of Bradford, European Regional Development Fund of the European Union
Research Development Fund Publication Prize Award winner.
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Tseng, Ya-Ching, and 曾雅晴. "Reduction- and pH-Sensitive Polymersomes Formed from Dithiomaleimide-Linked AB2-Type Amphiphilic Block Copolymers for On-Demand Drug Release." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/425pmy.
Повний текст джерелаКниги з теми "On-Demand release"
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Redbooks, IBM. Workspace On-Demand Handbook Release 2.0. Ibm, 1998.
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Naghib;, Seyed Morteza. Localized Micro/Nanocarriers for Programmed and on-Demand Controlled Drug Release. Bentham Science Publishers, 2022.
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Naghib, Seyed Morteza, Samin Hoseinpour, and Shadi Zarshad. Localized Micro/Nanocarriers for Programmed and on-Demand Controlled Drug Release. Bentham Science Publishers, 2022.
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Naghib;, Seyed Morteza. Localized Micro/Nanocarriers for Programmed and on-Demand Controlled Drug Release. Bentham Science Publishers, 2022.
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Managing Your Java Software With IBM Secureway On-Demand Server Release 2.0. Ibm, 1999.
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Self-Publishing on Demand: How to Create, Publish and Release Your Next Non-Fiction Book. Jones Media Publishing, 2016.
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Surdam, David George. An Overview of the Hearings. University of Illinois Press, 2017. http://dx.doi.org/10.5406/illinois/9780252039140.003.0003.
Повний текст джерелаАнотація:
This chapter provides an overview of the hearings conducted by Congress in the wake of player unrest after World War II and growing demand for new baseball franchises. The Congressional hearings began in 1951, when Emanuel Celler (N.Y.), chair of the House Subcommittee on Anti-trust and Monopoly, initiated an inquiry into Major League Baseball (MLB). For the first hearings, Celler told reporters that the committee's purpose was to “help baseball against itself.” During the hearings, few of the legislators impressed with their savvy. Some did not appear to understand the testimony. On occasion a few made dubious comments. The hearings occasionally lapsed into farce. The chapter considers sports owners' reluctance to release their financial records as well as professional sports leagues' search for antitrust exemptions.
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Buła, Piotr, and Bogdan Nogalski, eds. The Future of Management. Industry 4.0 and Digitalization. Wydawnictwo Uniwersytetu Jagiellońskiego, 2020. http://dx.doi.org/10.4467/k7123.106/20.20.15521.
Повний текст джерелаАнотація:
We believe that the world is standing on the very edge of the fastest industrial revolution ever. A revolution which will rapidly increase the efficiency of many production processes. Automation (both mechanical and the one happening with computer processes) will reduce the demand for human work and release a huge amount of time we can use for further development. With this book we try to provide the reader with information about various aspects of life and the socio-economic environment. For this purpose, we have invited authors representing the leading scientific research centers in Poland and specialists from foreign universities. Piotr Buła Bogdan Nogalski The monograph stands out from the publications related to change management in the context of entrepreneurial opportunities and flexibility of the organization. The authors attempt to integrate retrospective and prognostic approaches, so they not only assess the current status, but also point to challenges for management science. The work has been prepared by scholars whose authority in management sciences is undisputed. I positively assess the empirical and methodological layer of individual chapters of the monograph. Discussing the results of their scientific and research work, the authors presented the determinants of management processes described from the perspective of entrepreneurial opportunities and flexibility of the organization. Szymon Cyfert
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Buła, Piotr, and Bogdan Nogalski, eds. The Future of Management. Entrepreneurship, Change and Flexibility. Wydawnictwo Uniwersytetu Jagiellońskiego, 2019. http://dx.doi.org/10.4467/k7124.89/20.20.15520.
Повний текст джерелаАнотація:
We believe that the world is standing on the very edge of the fastest industrial revolution ever. A revolution which will rapidly increase the efficiency of many production processes. Automation (both mechanical and the one happening with computer processes) will reduce the demand for human work and release a huge amount of time we can use for further development. With this book we try to provide the reader with information about various aspects of life and the socio-economic environment. For this purpose, we have invited authors representing the leading scientific research centers in Poland and specialists from foreign universities. Piotr Buła Bogdan Nogalski The monograph stands out from the publications related to change management in the context of entrepreneurial opportunities and flexibility of the organization. The authors attempt to integrate retrospective and prognostic approaches, so they not only assess the current status, but also point to challenges for management science. The work has been prepared by scholars whose authority in management sciences is undisputed. I positively assess the empirical and methodological layer of individual chapters of the monograph. Discussing the results of their scientific and research work, the authors presented the determinants of management processes described from the perspective of entrepreneurial opportunities and flexibility of the organization. Szymon Cyfert
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Grewal, J. S. The Second Battle. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780199467099.003.0024.
Повний текст джерелаАнотація:
In May 1960, Master Tara Singh declared that the Sikhs would win or die in the battle for ‘Punjabi Suba’. Arrested two days later, he was released on 4 January 1961 for consultation with Sant Fateh Singh who was on fast. After Master Tara Singh’s assurance that the demand had been accepted in principle, Sant Fateh Singh broke his fast. But nothing came out of his talks with Nehru. Now Master Tara Singh went on fast on 15 August 1961. After his meeting with Jai Prakash Narayan, he was willing to accept arbitration. Three names suggested for a commission were acceptable to him and he broke his fast on 1 October. The Das Commission, instituted by the government with totally different personnel, was boycotted by the Akalis. Its verdict came in February 1962 that there was no discrimination against the Sikhs.
Частини книг з теми "On-Demand release"
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Yoshikawa, Jun-ichi, Kenzo Makino, and Akira Furusawa. "On-Demand Release of a Heralded Quantum State from Concatenated Optical Cavities." In Engineering the Atom-Photon Interaction, 217–40. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-19231-4_8.
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Riool, Martijn, and Sebastian A. J. Zaat. "Biomaterial-Associated Infection: Pathogenesis and Prevention." In Urinary Stents, 245–57. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-04484-7_20.
Повний текст джерелаАнотація:
AbstractThe use of medical devices, such as urinary stents, catheters, artificial heart valves, prosthetic joints and other implants, collectively often referred to as “biomaterials” has increased dramatically over the past century, and has become a major part of modern medicine and our daily life. With the aging society, the higher demand on these devices to restore function and quality of life, combined with the ever improving technology within the medical field, the problem of biomaterial-associated infection (BAI) is expected to increase.The most common causative microorganisms in BAI are Staphylococcus aureus, a major pathogen in wound infections, and Staphylococcus epidermidis, the harmless skin commensal. Depending on the type of device and location of application, other pathogens such as coagulase-negative staphylococci, enterococci, streptococci, Propionibacterium acnes and yeast can also cause BAI.Prevention of BAI is a challenging problem, in particular due to the increased risk of resistance development associated with current antibiotic-based strategies. Here we showed the evidence of biofilms as a source for peri-implant tissue colonization, clearly showing the importance of preventive measures to be able to act both against implant and tissue colonization. Subsequently, we described different strategies to prevent BAI and other difficult-to-treat biofilm infections. We conclude that future research should focus on the development of combination devices with both anti-fouling or contact-killing capacities—to protect the implant—and controlled release of an antimicrobial agent to protect the surrounding tissue.
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Turner-Adams, Hana, and Christine Rubie-Davies. "New Zealand: The Experiences of Māori Teachers as an Ethnic Minority in English-Medium Schools." In To Be a Minority Teacher in a Foreign Culture, 453–69. Cham: Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-25584-7_29.
Повний текст джерелаАнотація:
AbstractThis chapter discusses the experiences of Māori teachers who are currently or were previously employed in English-medium schools and early childhood centers in New Zealand. The New Zealand education system has a long history of failing to meet the educational needs of Māori students, and the demand for teachers to improve students’ academic outcomes has increased. Māori teachers connect and engage more readily with Māori students due to their shared culture and background. In contrast, many Pākehā/New Zealand European teachers have a limited understanding of Māori language, knowledge systems, values, and customs, and often hold low expectations for Māori student achievement. Findings from our study revealed that Māori teachers carried a substantial cultural and pastoral workload. On average, teachers reported spending at least 5½ hours per week working with Māori students and their whānau (family) in addition to their full-time teaching responsibilities. Although most teachers were acknowledged for their contributions through additional remuneration or time-release, others received no recognition. Participants were committed to their students but often worked in unwelcoming and unsupportive Eurocentric environments. Teachers were also disheartened by the general lack of commitment of their non-Māori colleagues to Māori language, culture, and values, yet were expected to guide, support, and educate these colleagues on how to meet their obligations to Māori students. The chapter concludes with suggestions for how school principals, center managers, and other teachers, could better support Māori teachers so that they continue making valuable contributions to their students’ education and remain employed in the teaching profession.
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Wendt, Jonas, Astrid Weyand, Boris Barmbold, and Matthias Weigold. "Approach for Design of Low Carbon Footprint Paint Shops in the Automotive Industry." In Lecture Notes in Mechanical Engineering, 490–98. Cham: Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-28839-5_55.
Повний текст джерелаАнотація:
AbstractTo mitigate the ongoing progress of climate change, the European Commission announced in the European Green Deal to reduce greenhouse gas emissions by 55% until 2030 compared to the reference year 1990 and to achieve climate neutrality by 2050 [1]. In this context, the industry in particular faces environmental challenges due to its high energy demand. To achieve the objective of becoming climate-neutral, increasing the energy and resource efficiency in the industry is crucial, because a large proportion of the greenhouse gases released are emitted during the provision of energy. In the automotive industry, paint shops are among the most energy-intensive processes and have great potentials for efficiency measures. These potentials can be identified with the assistance of energy or CO2 balancing methods. This publication presents a tool to analyse the energy efficiency potentials of automotive paint shops. The approach offers the possibility to parameterize different painting processes and their sub-processes. After defining the process requirements, a thermodynamic and process engineering simulation of the individual process steps enables the identification of potentials for energy and resource savings and CO2 reduction in existing or planned painting processes. In a validation on a real reference scenario, the simulated CO2 emissions of a paint shop were reduced by up to 24%.
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Bouacida, Ines. "France’s Hydrogen Strategy: Focusing on Domestic Hydrogen Production to Decarbonise Industry and Mobility." In Studies in Energy, Resource and Environmental Economics, 67–84. Cham: Springer Nature Switzerland, 2024. http://dx.doi.org/10.1007/978-3-031-59515-8_4.
Повний текст джерелаАнотація:
AbstractFrance was one of the European frontrunners in formulating policies to develop hydrogen for decarbonisation, releasing its first hydrogen plan in 2018. This was followed by a larger, €9-billion strategy in 2020 (to be updated in 2024), hot on the heels of plans released by the European Commission and Germany. The French strategy for hydrogen deployment focuses in particular on applications where hydrogen is key for deep decarbonisation, including refineries and the chemical industry as well as steel production, and the mobility sector. The country aims to have a head start on European and world competitors thanks to its large electricity resources from the existing nuclear fleet and by building new nuclear capacity. Additionally, it relies on several existing innovation hubs specialising in hydrogen, as well as on the support of many local governments involved in hydrogen development and a relatively structured hydrogen industry. The French strategy for hydrogen includes few ambitions at the international level beyond scientific and technological cooperation within the European Union. The political priority is to develop a domestic industry sized to meet national demand, which is seen as a more secure sourcing strategy than relying on imports. This comes in contrast with the positions of France’s neighbours, notably Spain, Portugal and Germany, which are pushing to enable cross-border trade of hydrogen as early as possible. This situation has generated political tensions within the European Union and in particular in the Franco-German relationship.
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Naghib, Seyed Morteza, Samin Hoseinpour, and Shadi Zarshad. "Exogeneous-triggered Delivery in Localized Controlled Drug Delivery Systems (LCDDSs)." In Localized Micro/Nanocarriers for Programmed and On-Demand Controlled Drug Release, 120–51. BENTHAM SCIENCE PUBLISHERS, 2022. http://dx.doi.org/10.2174/9789815051636122010007.
Повний текст джерелаАнотація:
Stimuli-sensitive materials and micro/nanostructures can be manipulated to release their therapeutic drugs in the target site. The release is based on a particular extracellular/cellular stimuli, triggered via physical, biochemical, and chemical changes. The trigger may change the carrier structure/chemistry to release the therapeutic drug at a specific site. When a therapeutic drug is encapsulated with a stimuli-triggered material/polymer, the release may start with changes in structures like charge switching, surface layers de-shedding and degradation of materials. Furthermore, the disruption of the bonds may result in the release of therapeutic agents that are covalently immobilized in the functional groups of materials. Exogenous stimuli are the activation of reactions/phenomena from outside the body, such as ultrasound, temperature and light. Herein, we will describe thermosensitive, light.sensitive, and ultrasound-sensitive controlled drug release of LCDDS, as the mentioned exogenous stimuli have been extensively used in LCDD applications.
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Naghib, Seyed Morteza, Samin Hoseinpour, and Shadi Zarshad. "Composites in Localized Controlled Drug Delivery Systems (LCDDSs)." In Localized Micro/Nanocarriers for Programmed and On-Demand Controlled Drug Release, 93–119. BENTHAM SCIENCE PUBLISHERS, 2022. http://dx.doi.org/10.2174/9789815051636122010006.
Повний текст джерелаАнотація:
Localized controlled drug delivery systems (LCDDSs) have become the main topic in drug delivery, tissue engineering and pharmaceutical science by enhancing formulations and processes of controlled delivery. The side effects and problems of materials/biomaterials are critical and may lead to several issues, such as reducing the effective drug dose, delaying the treatment process, and not having a particular continuous treatment. Therefore, composites composed of hybrid materials/biomaterials with excellent release properties, biocompatibility, stability and biodegradability, with local adjusted release rates, are an alternate choice for protective drug delivery. Several approaches to fabricating composite-based LCDDSs include emulsification-solvent evaporation, spray drying, electrospraying, supercritical fluids processing, microfluidics, and nanoprecipitation/solvent displacement and emulsion. This chapter describes the advances in micro/nanoscaled composite-based LCDDSs and their fabrication methods.
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Hoseinpour, Samin, and Shadi Zarshad. "Introduction to Localized Controlled Drug Delivery Systems (LCDDSs)." In Localized Micro/Nanocarriers for Programmed and On-Demand Controlled Drug Release, edited by Seyed Morteza Naghib, 1–19. BENTHAM SCIENCE PUBLISHERS, 2022. http://dx.doi.org/10.2174/9789815051636122010002.
Повний текст джерелаАнотація:
Localized controlled drug delivery systems (LCDDS) that can control drug release profiles to ensure high therapeutic efficacy and reduced side effects are highly desired in the pharmaceutical and biomedical fields. Biodegradable drug delivery depots have been investigated over the last several decades as the means to improve tumor targeting and severe systemic morbidities associated with intravenous chemotherapy treatments. These localized therapies exist in a variety of factors designed to facilitate the controlled drug delivery, directly to the disease site, sparing off-target tissue toxicities. Many of these depots are biodegradable and designed to maintain therapeutic concentrations of drugs at the tumor site for a prolonged period of time. The depots are placed inside the body through a single implantation procedure, sometimes simultaneously with the tumor excision surgery, following the complete release of the loaded active agent. Even though localized depot delivery systems have been widely investigated, only a small subset have demonstrated curative preclinical results for cancer applications, from which just a few have reached commercialization.
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Naghib, Seyed Morteza, Samin Hoseinpour, and Shadi Zarshad. "Additive Manufacturing in Developing Localized Controlled Drug Delivery Systems (LCDDSs)." In Localized Micro/Nanocarriers for Programmed and On-Demand Controlled Drug Release, 211–37. BENTHAM SCIENCE PUBLISHERS, 2022. http://dx.doi.org/10.2174/9789815051636122010010.
Повний текст джерелаАнотація:
Patients may show various defects to medications depending on race, gender, fitness, age, pharmacokinetic and health conditions. To address this challenge, there is a need to establish personalized, on-demand, programable and smart carriers that can control drug release with new and robust techniques. Additive manufacturing (AM) is the key sustenance of digital technology that has been developing and growing recently. AM offers several opportunities in localized controlled drug delivery systems (LCDDS), including materials recycling as well as on-site manufacturing, design freedom and full customization. Moreover, the industrial, biomedical and academic requests for AM for LCDDS have been continually rising, demonstrating significant marks for an extensive range of products. This chapter outlines AM approaches and their functions for LCDDS and describes AM technologies, such as recent advances in controlled drug release, as well as their processed materials and working principles. Furthermore, the benefits of 3D printing in the progressions of the LCDDS, the advantages of 4D printing, the impression of designing and material selection in these techniques are discussed. Finally, the potentials of AM approaches and their LCDD applications that designate a promising healthcare future are described.
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Naghib, Seyed Morteza, Samin Hoseinpour, and Shadi Zarshad. "Carbon Nanostructures in Localized Controlled Drug Delivery Systems (LCDDSs)." In Localized Micro/Nanocarriers for Programmed and On-Demand Controlled Drug Release, 20–45. BENTHAM SCIENCE PUBLISHERS, 2022. http://dx.doi.org/10.2174/9789815051636122010003.
Повний текст джерелаАнотація:
Nanotechnology has possible potential for developing future clinical applications. Nanoparticles may be used for biological and medical purposes due to their opportunities for multi-modal systems. Moreover, carbon nanostructures have received considerable attention in biomedicine. As an example, carbon nanomaterials have been extensively used to deliver therapeutic molecules in multi-functional controlled release systems. Carbon nanostructures may be used as nanocarriers, owing to their large surface area, privileged cumulation in tumors and excellent internalization in cancer cells. Carbon nanostructures may be used to deliver therapeutic agents preferentially to cancer tissues, to decrease side effects and cytotoxicity of drugs. However, the intrinsic cellular toxicity of carbon nanostructures remains a challenge. This chapter represents different characteristics of carbon nanostructures, resulting in their various applications in localized controlled drug delivery systems. Recent progress in methods and techniques for biofunctionalization, delivering and targeting by carbon nanostructures are presented and discussed.
Тези доповідей конференцій з теми "On-Demand release"
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Yao-Joe Yang, Yu-Jie Huang, Hsin-Hung Liao, Tao Wang, Pen-Li Huang, Chii-Wan Lin, Yao-Hong Wang, and Shey-shi Lu. "A release-on-demand wireless CMOS drug delivery SoC based on electrothermal activation technique." In 2009 IEEE International Solid-State Circuits Conference (ISSCC 2009). IEEE, 2009. http://dx.doi.org/10.1109/isscc.2009.4977421.
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Perkins, Jessica L., Salil Desai, Benjamin Harrison, and Jagannathan Sankar. "Understanding Release Kinetics of Calcium Alginate Microcapsules Using Drop on Demand Inkjet Printing." In ASME 2009 International Mechanical Engineering Congress and Exposition. ASMEDC, 2009. http://dx.doi.org/10.1115/imece2009-12819.
Повний текст джерелаАнотація:
This paper investigates the use of calcium alginate microcapsules to transport biomaterials for drug delivery. Rhodamine 6G dye was encapsulated in microcapsules for different formulations of the hydrogels using drop-on-demand printing. An experimental design was constructed to compare the effect of different concentrations of calcium chloride (M) and sodium alginate (% w/v) solutions in addition to the microcapsule diameter on the release kinetics profiles of the microcapsules. The results of these findings provide a basis to identify favorable sizes of microcapsules and concentrations of sodium alginate and calcium chloride solutions for controlled release behavior of microcapsules.
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Walter, Ian, Philip E. Paré, and Jitesh H. Panchal. "Modeling the Dynamics of Customer Demand to Determine the Optimal Time to Release Product Updates: A Cognitive Approach." In ASME 2023 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2023. http://dx.doi.org/10.1115/detc2023-115259.
Повний текст джерелаАнотація:
Abstract The nature of modern products is changing, and design processes need to change accordingly. As products become increasingly software-enabled and with the rise of software-as-a-service models, customer-facing updates can be released more frequently than was previously possible. The development pipelines for software-enabled products are shifting towards agile processes, which emphasize regular product updates, choosing the timing of these updates is important, and requires an understanding of how demand will be influenced by each release. However, the existing discrete-choice models used to predict demand do not capture the dynamic aspects of consumer decision making. To address this gap, we propose a dynamic demand model and demonstrate how it can be used to determine the optimal time to release product updates. The demand model is based on decision field theory (DFT), which enables the modeling of the dynamic and time-varying behavior of human decision makers. The primary contribution in this paper is a product strategy for update release schedules which accounts for the dynamic and time-varying behavior of potential customers. We demonstrate the method using simulations of multiple scenarios.
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Takatsuka, Shuhei, Takeshi Kubota, Yuta Kurashina, and Hiroaki Onoe. "Near Infrared-Triggered On-Demand Adeno-Associated Virus Release From Hydrogel Microbeads For Gene Therapy." In 2022 IEEE 35th International Conference on Micro Electro Mechanical Systems Conference (MEMS). IEEE, 2022. http://dx.doi.org/10.1109/mems51670.2022.9699702.
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Chiu, Stanley K. H., and Son T. Vuong. "A novel method for flash crowd avoidance in P2P video on demand streaming via pre-release distribution." In 2008 International Conference on Advanced Technologies for Communications (ATC). IEEE, 2008. http://dx.doi.org/10.1109/atc.2008.4760559.
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Nubli, Haris, Jung Min Sohn, and Dongho Jung. "Temperature Reduction on LNG Bunkering Ship Structure Under Accidental Cryogenic Gas Release Using CFD Simulation." In ASME 2022 41st International Conference on Ocean, Offshore and Arctic Engineering. American Society of Mechanical Engineers, 2022. http://dx.doi.org/10.1115/omae2022-78729.
Повний текст джерелаАнотація:
Abstract Liquefied Natural Gas (LNG) fuel has been proven to minimize sulfur oxide, nitrogen oxide, and particulate matter emissions. LNG fuel becomes a good option to fulfill an alternative fuel demand in shipping industries. Consequently, LNG bunkering ships have to deploy in order to meet the LNG bunkering infrastructure demand. In the event of an accidental LNG release, the cryogenic exposure causes embrittlement of steel that leads to the ship’s structural failure. The scope of this work is to establish accidental LNG release scenarios considering the leak and environment-related parameters, to observe the cryogenic flow and gas accumulation on the LNG bunkering ship’s structure. The reservoir pressure, leak size, leak directions, leak positions, and release rates are provided as the leak-related parameter. A wind rose data of Ulsan Port (South Korea) is utilized to determine the wind speed, wind direction, and ambient temperature as the environment-related parameter. The release duration is set in 15 minutes which is the emergency shutdown valve reaction time. Kameleon FireEx (KFX) was employed to execute the LNG release simulation. The grid and iteration convergence tests were presented to ensure the current model’s accuracy. Finally, the thermal footprints of structure and gas accumulation characteristics are discussed in this paper.
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Justin, G. A., Siqiang Zhu, T. R. Nicholson, J. Maskrod, J. Mbugua, M. Chase, June-ho Jung, and R. M. L. Mercado. "On-demand controlled release of anti-inflammatory and analgesic drugs from conducting polymer films to aid in wound healing." In 2012 34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). IEEE, 2012. http://dx.doi.org/10.1109/embc.2012.6346153.
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Stewart, Tiffanie, Emmanuel Stimphil, Rakesh Guduru, Alexandra Rodzinski, Ping Liang, Carolyn Runowicz, Ren-Zhi Cai, Luis Salgueiro, Andrew Schally, and Sakhrat Khizroev. "Abstract 1346: Magnetoelectric particles cross blood brain barrier to deliver anti-tumor peptide to glioblastoma cells with on-demand release." In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-1346.
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Kahl, Torsten, Georg Greifzu, Marion Herrmann, Wolfgang Lippmann, and Antonio Hurtado. "Particle Release During Laser Decontamination of Concrete Surfaces." In 2018 26th International Conference on Nuclear Engineering. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/icone26-81578.
Повний текст джерелаАнотація:
The phase–out of all Nuclear Power Plants (NPP) until 2022 in Germany offer the opportunity to apply new and efficient decommissioning technologies, which allow further reduction of decommissioning costs and minimization of the collective dose for personnel. One challenging task in this process is the decontamination of protective paints containing polychlorinated biphenyl (PCB). PCB-containing surfaces demand consecutive radiological decontamination and removal of the PCB-containing paints before the demolition is possible. Laser technology, commonly used in many different industrial sectors, presents an advanced approach to this problem. Successful thermal decomposition of PCB-containing paints using high power diode lasers has been reported by our group in former publications [1]. Ongoing investigations focus on the technology transfer from static laboratory state to industrial application. This includes the verification of safety and efficiency issues for the complete laser supported process. The current presentation covers all aspects of the laser process: concrete sample preparation as well as an experimental set-up utilizing a mobile laser system that includes an innovative laser head. Particular focus will be on the phenomena of the generated concrete surfaces and the arising by-products during laser processing. A 10 kW high power diode laser, Laserline LDF 1500-10000 was used for the ablation experiments. Concrete samples were coated with typical decontamination epoxy-based paints, which match the commonly used paint systems in German NPPs in terms of composition, structure and thickness. The influence of significant processing parameters (laser power, feed rate, type of concrete and composition of paint) on the laser ablation are shown in relation to the energy input per length. The release of particles is subjected to these parameters as well. Therefore the size and the shape of the arising particles have been measured online in accordance with these processing parameters by an Engine Exhaust Particle Sizer (EEPS, Model RP-3090, TSI) in a range between 5.6 to 560 nm. The quantity of particles has also been counted by a Condensation Particle Counter (CPC, Model 3022, TSI). Overall up to 6 million particles per cubic decimeter are detected with a dilution factor of 1:100 throughout the experiments. Both measuring systems are connected to the exhaust air pipe downstream, next to the laser head. The shift of the particle size in accordance with the above mentioned parameters is crucial for a comprehensive understanding of the laser decontamination. The mobile laser supported decontamination technology will be tested in 2018 in a German nuclear facility. This test will contain the decontamination process with actual surface configurations like floors, walls, ceilings and corners, and will act as an effective proof-of-concept for the developed laser system prototype.
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Rodzinski, Alexandra, Ali Hadjikhani, Tiffanie Stewart, Emmanuel Stimphil, Rakesh Guduru, Ping Liang, Carolyn Runowicz, and Sakhrat Khizroev. "Abstract B47: A novel mechanism for field-controlled high-specificity targeted anticancer drug delivery and on-demand release using magnetoelectric nanoparticles." In Abstracts: Fourth AACR International Conference on Frontiers in Basic Cancer Research; October 23-26, 2015; Philadelphia, PA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.fbcr15-b47.
Повний текст джерелаЗвіти організацій з теми "On-Demand release"
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Dabrovolskas, Audrius. In Search of Film Policy and Film Exhibition Model Based on Mission Economy: the Case of the Baltic Film Industries. Publishing House - Vilnius Business College, June 2023. http://dx.doi.org/10.57005/ab.2023.1.2.
Повний текст джерелаАнотація:
In Europe film industries are regulated through film policies at national and supra-national levels. The biggest attention is paid to film production and distribution, because they are considered as the most crucial sectors regarding financial investment. Film exhibition on the other hand is more about whole commercial life of a film and since theatrical admissions in European Union increased by 5.3 % (in 2019) before covid-19 pandemic it demonstrates that theatrical release is still among one of the most important release windows. Yet Lithuanian, Latvian, and Estonian film exhibition trends and their role for developing film policy were not examined. The qualitative and quantitative research methods applied: descriptive statistics and its analysis of secondary sources such as cinema attendance, the number of multiplexes and digital screens, premieres of national films and box-office and the analysis of film policy (regulatory) documents in Lithuania, Latvia, and Estonia. Economically film exhibition sector during covid-19 pandemic was heavily influenced and challenged by enormous decline in cinema attendance and the competition and rising role of audiovisual video-on-demand platforms. The article provides insights and findings based on the analysis of current role of film exhibition for the development of film policy and its possible model in the Baltic film industries.
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Baldos, Uris Lantz. Development of GTAP 9 Land Use and Land Cover Data Base for years 2004, 2007 and 2011. GTAP Research Memoranda, August 2017. http://dx.doi.org/10.21642/gtap.rm30.
Повний текст джерелаАнотація:
Understanding the challenges of achieving environmental sustainability goals given future demand for food, fiber and fuel requires economic models and databases that incorporate spatially explicit information on land use and land cover (LULC). The GTAP LULC database and its variants have been extensively used in a wide variety of applications aimed at examining the land-environment-energy nexus. Looking back the development of the first GTAP LULC was no simple task as it required the expertise of several researchers to identify and process relevant geospatial information. And because of this, succeeding updates of the GTAP LULC database (namely v.7 for 2004 and v.8 for 2004, 2007) relied heavily on AEZ-region level data from GTAP LULCv.6 in order to update land cover and land use as well as share-out land rents. This memorandum documents the development of the GTAP LULC v.9 database. In keeping with the multi-year release of GTAP v.9, the GTAP LULC v.9 data is developed for each benchmark year (i.e. 2004, 2007 and 2011). But unlike previous releases, GTAP LULCv.9 is created directly from publicly available high-resolution (i.e. 5-minute grid) spatial land cover and land use maps. Since these maps can be readily downloaded online, it is possible to replicate GTAP LULCv.9 if users know how to handle spatial data and if they follow the methods outlined in this document. Furthermore, by developing the capacity to handle spatial data within the Center, new spatial LULC information can be easily incorporated in future releases of the GTAP LULC.
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Baldos, Uris Lantz, and Erwin Corong. Development of GTAP 10 Land Use and Land Cover Data Base for years 2004, 2007, 2011 and 2014. GTAP Research Memoranda, November 2020. http://dx.doi.org/10.21642/gtap.rm36.
Повний текст джерелаАнотація:
Understanding the challenges of achieving environmental sustainability goals given future demand for food, fiber and fuel requires economic frameworks that incorporate spatially explicit information on land use and land cover (LULC). The GTAP LULC Data Base and its variants have been extensively used in a wide variety of applications aimed at examining the land-environment-energy nexus (Golub et al., 2012; Hertel et al., 2010; Johnson et al., 2019; Liu et al., 2014; Peña-Lévano et al., 2019; Stevenson et al., 2013; Taheripour et al., 2010; Taheripour & Tyner, 2012). The first release of the GTAP LULC Data Base combines geospatial data on land use and land cover into GTAP 6 Data Base – benchmarked to year 2001 (GTAP LULC v6). The methodology for creating and using this database is well documented (Lee et al., 2009; C. Monfreda et al., 2009; Sohngen et al., 2008). Succeeding updates of the GTAP LULC Data Base (namely v7 and v8 for 2004 and v8 for 2004, 2007) relied on readily available but aggregated GTAP LULC v6, albeit using national-level data from FAOSTAT (2020) (Avetisyan et al., 2010; Baldos & Hertel, 2012). Starting with GTAP 9, LULC was created directly from the latest, high-resolution (i.e. 5-minute) spatial land cover and land use maps in combination with national-level statistics (Baldos, 2017). This memorandum documents the development of the GTAP LULC version10A which is based on the GTAP v10A Data Base for years 2004, 2007, 2011 and 2014 (Aguiar et al., 2019). This update heavily relies on the methodology for creating GTAP LULC v9 which downscales national-level land cover and crop production statistics from FAOSTAT (2020) using publicly available spatial data (see Appendix I).
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Harris, Jeremy, Paolo Giordano, and Matthew Shearer. INTrade: Latin America Trade Trend Estimates: 2012. Inter-American Development Bank, December 2012. http://dx.doi.org/10.18235/0008200.
Повний текст джерелаАнотація:
After posting double digit gains in 2010-2011, Latin America's export growth declined to just 1.5% in 2012 for a total value of slightly more than $1 trillion, according to figures just released by the Integration and Trade Sector of the Inter-American Development Bank (IDB). These results reflected uneven economic conditions in Latin America's major trade partners. In Europe, economic setbacks resulted in a 5% drop in demand for Latin American exports, while lower growth in the People's Republic of China and the Republic of Korea sharply slowed the region's export growth to Asia as a whole, from 25% in 2011 to only 1% this year. In one bright spot, incipient recovery in the United States fueled growth in Latin American exports to that country by an estimated 3%. The 2012 trade estimates, published in the IDB's Latin American Trade Trend Estimates 2012, are based on partial monthly and quarterly data of 16 Latin American countries from official national and international sources, as well as the Bank's INTrade Information System.
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The underserved middle: defining excluded enterprises in agricultural value chains. Commercial Agriculture for Smallholders and Agribusiness (CASA), 2020. http://dx.doi.org/10.1079/20240191181.
Повний текст джерелаАнотація:
This brief is intended to establish the concept and quantify the size of the "underserved middle" in the agricultural value chains of sub-Saharan Africa, Latin America and Asia; this is the sector underserved by financial, policy and market-making institutions. The aim is to build on existing concepts and published information to provide clarity to the investor community and their financing partners on the definition and size of the underserved middle, as well as on existing opportunities for investment, as identified by the Commercial Agriculture for Smallholders and Agribusiness (CASA) programme. The underserved middle represents a diverse range of small and medium-sized enterprises (SMEs) at all stages of the value chain - though predominantly downstream of production - characterized as being unable to exploit the potential to scale up that exists in the market due to their effective exclusion from normal market-supporting policies, financing and institutions. This exclusion is largely due to the size of the enterprises: they are typically larger than micro enterprises, which can self-finance and operate successfully within their local social, political and economic ecosystem, but are smaller than large companies, which are attractive to external financiers and have the capacity to engage with and influence decision makers and institutions. Although figures are not available for the number of agricultural SMEs or their specific financing needs, very rough estimates of the financing gap range from $170 billion annually for all smallholder financing needs in sub-Saharan Africa, Latin America and Asia to $100 billion for agricultural SMEs in sub-Saharan Africa alone. More recent thinking is currently being done by Reardon and Jayne, and by institutions such as the World Bank on the complexity of the underserved middle, particularly in terms of access to finance, institutions and policymakers. Whilst formal financing remains difficult to obtain and is expensive, informal sources are likely to be more important than previously thought. Both the demand and supply of formal and informal financing vary considerably by type of enterprise and funding need. However, investors and other stakeholders also need to consider how changes to policy, regulation and infrastructure will unshackle excluded SMEs and release their ability to scale themselves up.
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The Competitive Advantage of Nations: A Successful Experience, Realigning the Strategy to Transform the Economic and Social Development of the Basque Country. Universidad de Deusto, 2015. http://dx.doi.org/10.18543/xiqr3861.
Повний текст джерелаАнотація:
Why do the new economy and welfare societies recommend a new station on the long journey towards competitiveness initiated within the framework of “The Competitive Advantage of Nations”, published as long as 25 years ago? A little more than twenty-five years ago, the Basque Country decided to equip itself with its own development strategy, undertaking to meet the challenge of designing its own future. The Basque Country aspired to give itself the maximum degree of self-government as a nation without a State, following its release from a long dictatorship which had plunged it into autarchy and isolation from the Western democracies around it, limiting its ability and responsibility to shape its own destiny and to offer its Society the highest standards of welfare, facing one of the greatest economic, political and social crises of its history and suffering from the ravages of terrorism within an economy castigated by soaring unemployment above 25%, a drop in its GDP, the fall, like dominoes, of its key industrial sectors, locked into the monoculture of the steel and metal working industry, outside the Europe which was being constructed by the then Economic Community of the Six, marginalized as a peripheral area from the future axis and development of the so-called “blue banana” of the London-Milan backbone and with an incipient and inexperienced administration, full of youth and enthusiasm, and a business world undergoing conversion, learning to live with a trade union phenomenon that the former dictatorship had bypassed. Faced with this complex and exciting challenge, those of us who had the privilege of addressing the aforementioned proposal, interpreting (by means of our analyses, as well as the wish to make our desires and dreams come true) the main keys to explain the state of the world economy, the main trends of change and their foreseeable impact on the Basque economy (“What the world economy taught us”), began the task of defining what we call “A strategy for the modernization and internationalization of our economy and our Country” trying to give some meaning to the role expected of the new players (States, city-regions, provinces, etc.), a role in which our small Country, with features of a City-Region, a sub-national entity, an invertebrate area on the two sides of the Pyrenees, could assume the figure of co-protagonist and provide society with a prosperous future. We also needed the framework and tools desirable for tackling the success strategy. We identified the gap between the needs that would be generated by the new paradigms and the tools offered by the existing political-economic framework (contents, skills, potential developments), accompanied by our own Country-strategy, with special emphasis on the initiatives, factors and critical vectors our society would demand and its aspirations for well-being and development. Within this context, the Basque Government approached Michael E. Porter, his ideas and concepts of the moment, and we began a collaborative process (which lasts until this day), constructing much more than our “Competitive Advantage of the Basque Country” in a thrilling and unfinished “Journey towards Competitiveness and Prosperity”. The Basque Country enjoys the privilege of having been the first nation to apply, in a strategic and comprehensive manner, the concepts which, a few years later, came to light in the prestigious publication we celebrate today, titled “The Competitive Advantage of Nations”, which has inspired the design of numerous policies and strategies throughout the world, which has brought about a proliferation of followers, which has trained instructors and which has generated a large number of new researchers and academics, new policy makers, new instruments for competitiveness and extraordinary levels of prosperity throughout the world. Since then, we have shared our own particular project which, alive and changing, responds to the new economic and social challenges and conflicts by constructing and applying a Country strategy with distinctive achievements and results beyond our economic environment. It lies within the conceptual framework inspired by the complementary tripod of Michael E. Porter's conceptual movement in his Competitive Advantage (Competitiveness, Shared Value Initiative and Social Progress) and our contributions learned from day to day in keeping with our vocation, identity, will and commitment. It is a never-ending process based on a model and a way of understanding the former pledge to give ourselves a single strategy designed by and for people.