Дисертації з теми "Nutrigenomics and personalised nutrition"
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Wilkins, Julianne G. "Knowledge and Perception of College Students Toward Genetic Testing for Personalized Nutrition Care." Kent State University / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=kent1491906065477344.
Повний текст джерелаTarasov, Stanislav. "Business solution for a food service company based on a modern nutrition concept (case of Russia)." Master's thesis, Vysoká škola ekonomická v Praze, 2011. http://www.nusl.cz/ntk/nusl-114364.
Повний текст джерелаGrosh, Kimberly Coile. "Nutrigenomics and Nutritional Epigenetics – The State of the Science in Academia." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1308247018.
Повний текст джерелаMcAuley, Emma. "Riboflavin, MTHFR genotype and blood pressure : implications for personalised nutrition." Thesis, Ulster University, 2016. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.706468.
Повний текст джерелаQuinn, Peter. "Applications of functional nutrition and nutrigenomics to improve public health through dietary interventions." Thesis, University of Liverpool, 2018. http://livrepository.liverpool.ac.uk/3023632/.
Повний текст джерелаStewart-Knox, Barbara J., A. Rankin, B. P. Bunting, L. J. Frewer, C. Celis-Morales, K. M. Livingstone, A. R. H. Fischer, et al. "Self-efficacy, habit strength, health locus of control and response to the personalised nutrition Food4Me intervention study." Emerald, 2006. http://hdl.handle.net/10454/18568.
Повний текст джерелаPurpose – Randomised controlled trials identify causal links between variables but not why an outcome has occurred. This analysis sought to determine how psychological factors assessed at baseline influenced response to personalised nutrition. Design/methodology/approach – Web-based, randomised, controlled trial (RCT) was conducted across seven European countries. Volunteers, both male and female, aged over 18 years were randomised to either a non-personalised (control) or a personalised (treatment) dietary advice condition. Linear mixed model analysis with fixed effects was used to compare associations between internal and external health locus of control (HLoC), nutrition self-efficacy (NS-E) and self-report habit index (S-RHI) at baseline (N 5 1444), with healthy eating index (HEI) and Mediterranean diet index (MDI) scores between conditions post-intervention (N 5 763). Findings – An increase in MDI scores was observed between baseline and six months in the treatment group which was associated with higher NS-E (p
EU FP7 Project “Personalised nutrition: an integrated analysis of opportunities and challenges” (Contract No. KBBE. 2010.2.3–02, Project No. 265494)
Stewart-Knox, Barbara, A. Rankin, B. P. Bunting, L. J. Frewer, C. Celis-Morales, K. M. Livingstone, A. R. H. Fischer, et al. "Self-efficacy, habit strength, health locus of control and response to the personalised nutrition Food4Me intervention study." Emerald, 2021. http://hdl.handle.net/10454/18568.
Повний текст джерелаPurpose – Randomised controlled trials identify causal links between variables but not why an outcome has occurred. This analysis sought to determine how psychological factors assessed at baseline influenced response to personalised nutrition. Design/methodology/approach – Web-based, randomised, controlled trial (RCT) was conducted across seven European countries. Volunteers, both male and female, aged over 18 years were randomised to either a non-personalised (control) or a personalised (treatment) dietary advice condition. Linear mixed model analysis with fixed effects was used to compare associations between internal and external health locus of control (HLoC), nutrition self-efficacy (NS-E) and self-report habit index (S-RHI) at baseline (N 5 1444), with healthy eating index (HEI) and Mediterranean diet index (MDI) scores between conditions post-intervention (N 5 763). Findings – An increase in MDI scores was observed between baseline and six months in the treatment group which was associated with higher NS-E (p
EU FP7 Project “Personalised nutrition: an integrated analysis of opportunities and challenges” (Contract No. KBBE. 2010.2.3–02, Project No. 265494)
Li, Sherly (Xueyi). "The interplay between genes and dietary factors in the aetiology of Type 2 Diabetes Mellitus." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/275094.
Повний текст джерелаCoelho, Carolina de Almeida. "Perfil metabólico e do estado nutricional de crianças e adolescentes de escolas da cidade de Ribeirão Preto, São Paulo, Brasil." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/17/17144/tde-11032014-090751/.
Повний текст джерелаIntroduction: Few studies have correlated metabolic profile and nutritional status in children and adolescents after dietary intervention . Objectives: To identify the existence of different metabolic groups formed by individuals 9-13 years undergoing nutritional intervention through biochemical data (glucose levels, total cholesterol, triglycerides, VLDL cholesterol, LDL cholesterol and HDL cholesterol) collected in three stages of the study, and to describe the longitudinal evolution of the nutritional and metabolic profile in these groups. Methodology: Clinical intervention self-controlled study, based on measuring the biochemical profile (glucose levels, total cholesterol, triglycerides, VLDL cholesterol, LDL cholesterol and HDL cholesterol) and nutritional status (anthropometry, body composition and dietary intake data) at three times: at baseline (before the intervention started), after six weeks of supplementation of vitamins and minerals and after more six weeks without this intervention, to assess how an individual, 9-13 years old answered the multiple micronutrient supplementation. Physical activity level was also assessed through a tool called bodybugg®. Results: One hundred and thirty six subjects were studied until the third moment of the data collection. 43.4% were male and 56.6% were female. The average age was 11.39 ± 1.10 years. Most participants belonged to pubertal stage 2 (43.4%) and 3 (35.3%). Regarding the economic status of the participants, the majority belonged to the category B2 (38.2%) and C1 (26.5%). Of the total sample, at moment 1, 4.4% of participants had severe underweight, 5.9% were underweight, 41.9% were with the proper weight, 22.8% were overweight and 25% were obese. At the moment 2, 3.7% of participants had severe underweight, 7.4% were underweight, 42.6% had normal weight, 22.1% were overweight and 24.3% were obese. And at the moment 3, 3.7% of participants had severe thinness, 6.6% were underweight, 41.2% had normal weight, 22.8% were overweight and 25.7% were obese. On average we found: 3.7% of participants with severe thinness, 5.9% with malnutrition, 41.9% with adequate weight, 24.3% overweight and 24.3% obese. The clustering of the participants used as criteria the metabolic profile (glucose levels, total cholesterol, triglycerides, VLDL cholesterol, LDL cholesterol and HDL cholesterol) of the three stages of the study through the statistical approach K - cluster. Cluster 1 (n = 111) had a higher proportion of females when compared to cluster 2 (n = 25) (p = 0.006) and better metabolic profile (lipid and glycemia). Participants who had better metabolic profile (cluster 1) showed lower weight, body mass index (BMI), waist circumference (WC) and fat mass (weight %) when compared to participants in cluster 2. Lean body mass (weight %) and total body water (% weight) were statistically higher in participants in cluster 1. The analysis of the habitual intake (food frequency questionnaire - FFQ) showed that participants in cluster 1 were had higher intake of vitamin B2 and vitamin B6 when compared to cluster 2 (p < 0,05). Cluster 1 also showed higher values C - reactive protein (CRP) and higher levels of iron. The latent capacity for iron binding (UIBC) and leukocytes were higher in cluster 2. There was no difference between the level of physical activity practiced by clusters 1 and 2, both had light physical activity. Longitudinal analysis showed that there was an increase in height and weight in clusters 1 and 2. A longitudinal assessment of usual intake (FFQ) in cluster 1 showed reduced intake of energy, carbohydrate, protein and lipid from moment 1 (M1) to moment 2 (M2) and moment 3 (M3). Supplementation with vitamins showed significant statistical results, consistent with supplementation and washout for most vitamins and minerals in clusters 1 and 2. A longitudinal analysis (correcting for age, gender, pubertal stage, and energy intake, carbohydrate and lipid) in cluster 1 showed that total cholesterol and LDL decreased throughout the study, blood glucose decreased from time 1 to time 2, but CRP increased in moment 2; hemoglobin and serum iron decreased from 1 to 2 and from 1 to 3. In cluster 2, total cholesterol and LDL decreased throughout the study, CRP increased throughout the study, serum iron decreased from time 1 to time 2. Conclusions: We found two reverse metabolic groups. Individuals may respond differently to the same intervention, and it is possible that multiple micronutrient supplementation has a role in improving glycemia and lipid profile of some subjects. Genotyping and proteomics studies may reinforce this hypothesis and help understand how the biological system of children and adolescents interact to culminate in a response against an intervention.
Lima, Ana Rita da Cunha. "Nutrigenómica." Master's thesis, [s.n.], 2014. http://hdl.handle.net/10284/4430.
Повний текст джерелаNuma sociedade cada vez mais preocupada com a saúde, a nutrição tem desempenhado um papel muito importante, não só com a causa da doença, mas também como uma forma de prevenção da doença. Isto ocorre porque os nutrientes são capazes de interagir com os mecanismos moleculares do organismo e assim, modificar as funções fisiológicas. A nutrigenómica (o estudo dos nutrientes na expressão dos genes) pode assim ser explorada de duas formas: os alimentos podem influenciar a atividade dos genes, e os genes podem influenciar a necessidade de certos nutrientes. Isto proporciona uma compreensão genética de como os componentes da dieta comum poderão afetar o equilíbrio entre a saúde e a doença, alterando desta forma a expressão e ou estrutura da composição genética de um individuo. Apesar de os indivíduos serem diferentes uns dos outros, o genoma é 99,9% semelhante entre eles. Esta diferença de 0.1% representa variações visíveis como a cor do cabelo, pele e olhos e diferenças mais subtis, como o aumento de predisposição para desenvolver doenças crónicas e a necessidade de determinados nutrientes e compostos bioativos. As várias mudanças nos hábitos alimentares e estilo de vida que surgem no dia-a-dia das pessoas podem assim estar relacionadas com o aparecimento de doenças influenciadas pela alimentação. Assim, lições de Nutrigenómica mostram a importância de consciencializar as pessoas para a importância da nutrição no estado de saúde de cada ser humano individual. No presente trabalho, pretende-se transmitir ao leitor uma visão compreensível mas ampla e detalhada de como a nutrigenómica é importante e quais as vantagens de usar esta ferramenta de estudo. In an increasingly health-conscious society, nutrition has played a very important role not only as the cause of disease but also as a way of disease prevention. This occurs because nutrients are able to interact with the organism’s molecular mechanisms and thereby modify physiological functions Nutrigenomics (the study of the influence of nutrients in gene expression) can thus be explored in two ways: food can influence the activity of genes and; genes can influence the need for certain nutrients. This provides an understanding of how the genetic components of common diets may affect the balance between health and disease, thereby altering the expression or structure and the genetic makeup of an individual. Despite being different from each other individual, the Human Genome is 99,9 % similar between individuals. This 0.1 % difference accounts for visible variations such in hair, skin and eye color and more subtle differences such as the increased predisposition to develop chronic diseases and the need for certain nutrients and bioactive compounds. The various changes in eating habits and lifestyle that arise in the day-to-day life of people can thus be related to the onset of diet-related disorders. Thus, lessons from Nutrigenomics indicate the importance of making people aware of the relevance of nutrition in the health status of every individual human being. The present work, aims at providing the reader with a comprehensive but broad and detailed view of how nutrigenomics is important and what are the advantages of using this study tool.
Sayruamyat, Suwanna. "Impacts of attitudes and personality traits on weight goals and willingness to pay for a personalised nutrition programme in Thailand." Thesis, University of Reading, 2018. http://centaur.reading.ac.uk/78983/.
Повний текст джерелаShiyab, Amy S. "Knowledge and Perception of Nutritional Genomics Among Registered Dietitian Nutritionists." Kent State University / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=kent1563187321042113.
Повний текст джерелаBOMBA, LORENZO. "Effect of dietary changes during weaning on gut gene expression in animal models." Doctoral thesis, Università Cattolica del Sacro Cuore, 2012. http://hdl.handle.net/10280/1314.
Повний текст джерелаAn incorrect diet increases the risk of diseases as insulin resistance and obesity. This thesis aims at assessing the effects of unbalanced diets on gut physiology and gene expression in pig and mouse during weaning. The first research explored the impact of a high fat diet in C57BL/6 mice. High-fat-fed mice and control-fed mice were sacrificed after two weeks of treatment. Gene expression level was assessed by 90K Combimatrix microarray technology. Four of seven genes found differentially expressed between control and high fat diet mice are involved in the regulatory pathway of the circadian clock system, which was recently shown to affect lipid metabolism and inflammatory processes. Those genes were successfully validated by real time PCR. The second study aimed at understanding the weaning effect with or without acidifier addition in the diet. Piglets at weaning (T0) were compared to piglets after one week (T1). The post-weaning group was fed a conventional diet, half of which received in addition sorbic acid. The sorbic acid supplementation evidenced no effects in terms of physiology and gene expression. 205 genes were significantly differentially expressed in T1 when compared with T0, evidencing a response to the metabolic adaptation and the stress suffered during weaning.
Konstantinidou, Valentini. "Molecular mechanisms involved in the protective effect of Mediterranean diet and olive oil consumption in humans." Doctoral thesis, Universitat Pompeu Fabra, 2010. http://hdl.handle.net/10803/7208.
Повний текст джерелаEl objetivo de este estudio es investigar si el papel protector de la dieta Mediterránea tradicional (TMD) y del aceite de oliva virgen (VOO), rico en compuestos fenólicos (PC), puede ser mediado a través de cambios en la expresión génica. Se realizaron dos ensayos clínicos para evaluar los efectos nutrigenómicos de la TMD y del VOO, in vivo, en voluntarios sanos. Los resultados mostraron a) cambios en la expresión génica de genes relacionados con el riesgo cardiovascular tras la ingestión del aceite virgen de oliva, b) una infra-expresión en la expresión de genes relacionados con el proceso aterosclerótico tras una intervención con TMD de 3 meses y c) que los compuestos fenólicos del aceite de oliva ejercen un efecto nutrigenómico protector en el marco de la TMD. Los cambios en la expresión génica fueron coherentes.
Castro, Rita de Cássia Borges de. "Efeito do ácido docosahexaenoico (DHA) sobre eventos epigenéticos em diferentes linhagens de câncer de mama." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/5/5155/tde-03102013-094648/.
Повний текст джерелаEpigenetic changes, such as DNA methylation and post-translational histone modifications, play an important role in mammary tumorigenesis. Epigenetic events are important as therapeutic targets, because of its reversible nature. Experimentally, docosahexaenoic acid (DHA), a member of the omega-3 fatty acids family, can reduce proliferation, induce apoptosis and decrease the invasive potential of breast tumor cells. However, the antitumor mechanism of DHA and its ability to modulate epigenetic events are not completely understood. Our objective was to verify, in vitro, the action of DHA in epigenetic events related to transcriptional reactivation of tumor suppressor gene, such as RASSF1A, in different human breast cancer cell lines. Three breast cancer cell lines (MCF-7, MDA-MB-231, SKBR-3) were treated with DHA (100 ?M) or vehicle (ethanol) for 72 hours. Western blot was used to analyze histone modification, as histone H3 lysine 9 (H3K9ac) and histone H4 lysine 16 (H4K16ac) acetylation, H3K9 trimethylation (H3K9me3) and H3K27 trimethylation (H3K27me3). Real time quantitative PCR (RT-qPCR) was performed for gene expression quantification of RASSF1A, DNMT1, DNMT3A and DNMT3B. DNA methylation of the promoter region of RASSF1A was evaluated by methylation specific PCR (MS-PCR). Moreover, we evaluated the phases of the cell cycle by flow cytometry. Compared to control cells, DHA induced H4K16ac in MCF-7 (p=0.04) and MDA-MB-231 (p=0.03). We observed that H3K9me3 was partially inhibited in MDA-MB-231 and SKBR-3 cells, after treatment with DHA, but did not reach a statistically significant value. We also found decreased levels of H3K27me3 after treatment with DHA in the three cell lines studied, but not statistically significant. DHA increased RASSF1A expression on MCF-7 (1.98 fold; p=0.03), but not in MDA-MB-231 and in SKBR-3 cells. There were no statistically significant changes in expression of genes DNMT1, DNMT3A and DNMT3B. These three breast cancer cells lines show methylation in specific region of RASSF1A promoter. DHA treatment increased RASSF1A promoter region hypomethylation in MCF-7 and SKBR-3. No significant difference was observed in the percentage of cell death nor cell distribution of MDA-MB-231, SKBR-3 and MCF-7 at different stages of the cell cycle after treatment with DHA. In conclusion, we suggest that DHA may act beneficially in epigenetic mechanisms and reactivation of tumor suppressor gene, RASSF1A as previously silenced by hypermethylation. It is hoped that these results can contribute to better understanding of the anticancer role of DHA in breast cancer
Abrahams, Mariëtte, L. J. Frewer, Eleanor J. Bryant, and Barbara Stewart-Knox. "Perceptions and experiences of early-adopting registered dietitians in integrating nutrigenomics into practice." 2017. http://hdl.handle.net/10454/13480.
Повний текст джерелаPurpose - This research explores the perceptions and experiences of early adopters of the technology. Design/Method/Approach - Registered Dietitians (RD´s) (N=14) were recruited from the UK, Canada, South-Africa, Australia, Mexico and Israel. Six qualitative interviews and two focus groups were conducted online using a conference calling platform. Data were recorded, transcribed and thematically analysed. Findings - Early adopters of Nutrigenomics (NGx) were experienced, self-efficacious RD’s who actively sought knowledge of NGx through communication with one another and the broader scientific community. They considered NGx an extension of current practice and believed RD’s had the skills to deliver it. Perceived barriers to widening the application of NGx were linked to skepticism among the wider dietetics community. Proliferation of unregulated websites offering tests and diets was considered ‘pseudoscience’ and detrimental to dietetics fully embracing NGx. The lack of a sustainable public health model for the delivery of NGx was also perceived to hinder progress. Results are discussed with reference to ‘diffusion of innovation theory’. Originality/Value - The views of RD’s who practice NGx have not been previously studied. These data highlight requirements for future dietetic training provision and more inclusive service delivery models. Regulation of NGx services and formal recognition by professional bodies is needed to address the research/practice translation gap.
Rankin, A., B. P. Bunting, R. Poinhos, der Lans I. A. van, A. R. H. Fischer, L. J. Frewer, and Barbara Stewart-Knox. "Food choice motives, attitudes toward and intention to adopt personalised nutrition." 2018. http://hdl.handle.net/10454/15509.
Повний текст джерелаObjective: This study explored associations between food choice motives, attitudes towards, 5 and intention to adopt personalised nutrition in order to inform communication strategies 6 based on consumer priorities and concerns. Design and Setting: A survey was administered 7 online which included the food choice questionnaire (FCQ), and items assessing attitudes 8 towards and intention to adopt personalised nutrition. Participants: Nationally representative 9 samples were recruited in 9 EU countries (N=9381). Results: Structural equation modelling 10 indicated that the food choice motives, weight control, mood, health and ethical concern had 11 a positive association and price had a negative association with attitude towards, and 12 intention to adopt, personalised nutrition. Health was positively associated and familiarity 13 negatively associated with attitude toward personalised nutrition. The effects of weight 14 control, ethical concern, mood and price on intention to adopt personalised nutrition were 15 partially mediated by the attitude. The effects of health and familiarity were fully mediated 16 by attitude. Sensory appeal was negatively and directly associated with intention to adopt 17 personalised nutrition. Conclusion: Personalised nutrition providers may benefit from taking 18 into consideration the importance of underlying determinants of food choice, particularly 19 weight control, mood and price, in potential users when promoting services and in tailoring 20 communications that are motivationally relevant.
Post peer-review accepted manuscript; changes are in red.
Stewart-Knox, Barbara, Jerko Markovina, A. Rankin, B. P. Bunting, S. Kuznesof, A. R. H. Fischer, der Lans I. A. van, et al. "Making personalised nutrition the easy choice: creating policies to break down the barriers and reap the benefits." 2016. http://hdl.handle.net/10454/8904.
Повний текст джерелаPersonalised diets based on people’s existing food choices, and/or phenotypic, and/or genetic information hold potential to improve public dietary-related health. The aim of this analysis, therefore, has been to examine the degree to which factors which determine uptake of personalised nutrition vary between EU countries to better target policies to encourage uptake, and optimise the health benefits of personalised nutrition technology. A questionnaire developed from previous qualitative research was used to survey nationally representative samples from 9 EU countries (N = 9381). Perceived barriers to the uptake of personalised nutrition comprised three factors (data protection; the eating context; and, societal acceptance). Trust in sources of information comprised four factors (commerce and media; practitioners; government; family and, friends). Benefits comprised a single factor. Analysis of Variance (ANOVA) was employed to compare differences in responses between the United Kingdom; Ireland; Portugal; Poland; Norway; the Netherlands; Germany; and, Spain. The results indicated that respondents in Greece, Poland, Ireland, Portugal and Spain, rated the benefits of personalised nutrition highest, suggesting a particular readiness in these countries to adopt personalised nutrition interventions. Greek participants were more likely to perceive the social context of eating as a barrier to adoption of personalised nutrition, implying a need for support in negotiating social situations while on a prescribed diet. Those in Spain, Germany, Portugal and Poland scored highest on perceived barriers related to data protection. Government was more trusted than commerce to deliver and provide information on personalised nutrition overall. This was particularly the case in Ireland, Portugal and Greece, indicating an imperative to build trust, particularly in the ability of commercial service providers to deliver personalised dietary regimes effectively in these countries. These findings, obtained from a nationally representative sample of EU citizens, imply that a parallel, integrated, public-private delivery system would capture the needs of most potential consumers.
Food4me is the acronym of the EU FP7 Project ‘‘Personalised nutrition: an integrated analysis of opportunities and challenges” (Contract No. KBBE.2010.2.3-02, ProjectNo.265494), http:// www.food4me.org/.
Rankin, A., B. P. Bunting, R. Poinhos, der Lans I. A. van, A. R. H. Fischer, S. Kuznesof, M. D. V. Almeida, Jerko Markovina, L. J. Frewer, and Barbara Stewart-Knox. "Food choice motives, attitude towards and intention to adopt personalised nutrition." 2018. http://hdl.handle.net/10454/18166.
Повний текст джерелаThe present study explored associations between food choice motives, attitudes towards and intention to adopt personalised nutrition, to inform communication strategies based on consumer priorities and concerns. Design/Setting: A survey was administered online which included the Food Choice Questionnaire (FCQ) and items assessing attitudes towards and intention to adopt personalised nutrition. Subjects: Nationally representative samples were recruited in nine EU countries (n 9381). Results: Structural equation modelling indicated that the food choice motives ‘weight control’, ‘mood’, ‘health’ and ‘ethical concern’ had a positive association and ‘price’ had a negative association with attitude towards, and intention to adopt, personalised nutrition. ‘Health’ was positively associated and ‘familiarity’ negatively associated with attitude towards personalised nutrition. The effects of ‘weight control’, ‘ethical concern’, ‘mood’ and ‘price’ on intention to adopt personalised nutrition were partially mediated by attitude. The effects of ‘health’ and ‘familiarity’ were fully mediated by attitude. ‘Sensory appeal’ was negatively and directly associated with intention to adopt personalised nutrition. Conclusions: Personalised nutrition providers may benefit from taking into consideration the importance of underlying determinants of food choice in potential users, particularly weight control, mood and price, when promoting services and in tailoring communications that are motivationally relevant.
Stewart-Knox, Barbara, A. Rankin, S. Kuznesof, R. Poinhos, Almeida M. D. V. de, A. R. H. Fischer, and L. J. Frewer. "Promoting healthy dietary behaviour through personalised nutrition: technology push or technology pull?" 2014. http://hdl.handle.net/10454/6720.
Повний текст джерелаThe notion of educating the public through generic healthy eating messages has pervaded dietary health promotion efforts over the years and continues to do so through various media, despite little evidence for any enduring impact upon eating behaviour. There is growing evidence, however, that tailored interventions such as those that could be delivered online can be effective in bringing about healthy dietary behaviour change. The present paper brings together evidence from qualitative and quantitative studies that have considered the public perspective of genomics, nutrigenomics and personalised nutrition, including those conducted as part of the EU-funded Food4Me project. Such studies have consistently indicated that although the public hold positive views about nutrigenomics and personalised nutrition, they have reservations about the service providers’ ability to ensure the secure handling of health data. Technological innovation has driven the concept of personalised nutrition forward and now a further technological leap is required to ensure the privacy of online service delivery systems and to protect data gathered in the process of designing personalised nutrition therapies.
Fallaize, R., A. L. Macready, L. T. Butler, J. A. Ellis, A. Berezowska, A. R. H. Fischer, M. C. Walsh, et al. "The perceived impact of the National Health Service on personalised nutrition service delivery among the UK public." 2015. http://hdl.handle.net/10454/7211.
Повний текст джерелаPersonalised nutrition (PN) has the potential to reduce disease risk and optimise health and performance. Although previous research has shown good acceptance of the concept of PN in the UK, preferences regarding the delivery of a PN service (e.g. online v. face-to-face) are not fully understood. It is anticipated that the presence of a free at point of delivery healthcare system, the National Health Service (NHS), in the UK may have an impact on end-user preferences for deliverances. To determine this, supplementary analysis of qualitative data obtained from focus group discussions on PN service delivery, collected as part of the Food4Me project in the UK and Ireland, was undertaken. Irish data provided comparative analysis of a healthcare system that is not provided free of charge at the point of delivery to the entire population. Analyses were conducted using the ‘framework approach’ described by Rabiee (Focus-group interview and data analysis. Proc Nutr Soc 63, 655-660). There was a preference for services to be led by the government and delivered face-to-face, which was perceived to increase trust and transparency, and add value. Both countries associated paying for nutritional advice with increased commitment and motivation to follow guidelines. Contrary to Ireland, however, and despite the perceived benefit of paying, UK discussants still expected PN services to be delivered free of charge by the NHS. Consideration of this unique challenge of free healthcare that is embedded in the NHS culture will be crucial when introducing PN to the UK.
Stewart-Knox, Barbara, B. P. Bunting, S. Gilpin, H. J. Parr, S. Pinhao, J. J. Strain, Almeida M. D. V. de, and M. J. Gibney. "Attitudes toward genetic testing and personalised nutrition in a representative sample of European consumers." 2009. http://hdl.handle.net/10454/6206.
Повний текст джерелаStewart-Knox, Barbara, S. Kuznesof, J. Robinson, A. Rankin, K. Orr, M. Duffy, R. Poinhos, et al. "Factors influencing European consumer uptake of personalised nutrition. Results of a qualitative analysis." 2013. http://hdl.handle.net/10454/6205.
Повний текст джерелаMota, Francisco Borges. "Relatórios de Estágio e Monografia intitulada “Nutrigenética e Nutrigenómica: Será Este o Futuro da Nutrição?”." Master's thesis, 2021. http://hdl.handle.net/10316/99134.
Повний текст джерелаNos últimos anos, o grande desenvolvimento nas áreas da biologia molecular, genética e nutrição, juntamente com a sequenciação completa do genoma humano, permitiram que a nutrição entrasse numa nova era, onde os nutrientes são reconhecidos como sendo capazes de interagir e alterar os mecanismos moleculares envolvidos nos processos fisiológicos do corpo humano, e, onde o perfil genético de cada indivíduo consegue determinar a resposta do nosso organismo a certos nutrientes. Surgem assim a nutrigenética, que estuda a influência que as variações genéticas têm na resposta do corpo à nossa alimentação, e a nutrigenómica, que estuda a influência dos nutrientes na expressão do nosso genoma. Estas duas ciências apresentam-se como o futuro promissor da nutrição, tendo o potencial para que, no futuro, consigam explicar a interação complexa entre os nutrientes e o genoma humano, permitindo aplicar estes conhecimentos na prevenção e controlo de doenças genéticas e crónicas. No entanto, a nutrigenética e a nutrigenómica ainda são áreas embrionárias, sendo necessário ainda muitos estudos para se conseguir perceber totalmente esta relação complexa, e de que forma podemos aplicar isso na prática clínica. O presente trabalho, pretende demonstrar que papel a nutrigenética e a nutrigenómica poderão ter no futuro desenvolvimento da nutrição, onde será apresentado de que forma a nutrigenética e a nutrigenómica, tentam perceber o papel da interação nutriente-genoma no aparecimento das várias doenças dentro da população, e de que forma a nutrição personalizada permite auxiliar na prevenção e controlo dessas doenças, melhorando assim a saúde da população. Além disto, serão abordados alguns riscos e obstáculos inerentes ao desenvolvimento destas ciências, e também qual o papel que o farmacêutico poderá desempenhar nestas áreas.
In the last few years, the great development in the fields of molecular biology, genetics and nutrition, alongside with the whole human genome sequencing, allowed nutrition to enter a new era, where the nutrients are capable of interacting and modulating the molecular mechanisms underlying the physiological processes of the human body, and where the genetic profile of each individual, can determine the organism’s response to the diet. Thus, this led to the arise of nutrigenetics, that studies the influence of genetic variations on the body’s response to the diet, and nutrigenomics, that studies the impact of the nutrients on genome expression. These two sciences are presented as the promising future of the nutritional science, having the potential in the future, to explain the complex interaction between nutrients and the human genome, allowing the application of this acknowledgments in the prevention and management of genetic and chronic diseases. However, nutrigenetics and nutrigenomics still are embryonic sciences, and numerous studies will be necessary for the understanding of this complex interaction, and how we can apply this to the clinical practice. This present work aims to demonstrate what role, nutrigenetic and nutrigenomics will have on the future development of nutrition, where it will be presented how nutrigenetics and nutrigenomics try to understand the nutrient-genome interaction’s role in the occurrence of the various diseases in the human population, and, how personalized nutrition can assist in the prevention and management of these diseases, improving the population’s overall health. Furthermore, it will be discussed the inherent risks and barriers in the development of these sciences, as well as the pharmacist’s role in these areas.
Stewart-Knox, Barbara. "Personalised nutrition: Making it happen." 2019. http://hdl.handle.net/10454/16829.
Повний текст джерелаPersonalised Nutrition allows individual variation in dietary, lifestyle, anthropometric, phenotypic and/or genomic information to be considered when giving dietary advice. Compared to ‘generic’ dietary health messages, personalised dietary advice has been shown more likely to result in healthy dietary change. Personalised regimes can help clients in this endeavour by putting them in control and taking into consideration individual propensity for behaviour change, motives for food choice as well as social and lifestyle factors impacting upon the eating context. Provision of personalised nutrition services across Europe should consider inter-country differences in perceived barriers to uptake of personalised nutrition including those associated with the process from the collecting of information and taking of biological samples through to how the results are interpreted and delivered. Irrespective of European country, potential consumers appear to trust health professionals such as dietitians over commercial agents to provide personalised nutrition. Dieticians, therefore, are likely to play a key role in making personalised nutrition happen in the future. Organisations representing nutrition and dietetics professionals will need to be consulted for guidance on how to address the ethical and legal issues around personalised nutrition and regulate practice. A future is envisaged where commercial personalised nutrition will work with existing health providers in bringing the benefits of personalised nutrition to the wider public.
The full text is unavailable in the repository due to copyright restrictions.
Fischer, A. R. H., A. Berezowska, der Lans I. A. van, A. Ronteltap, A. Rankin, S. Kuznesof, R. Poínhos, Barbara Stewart-Knox, and L. J. Frewer. "Willingness to pay for personalised nutrition across Europe." 2016. http://hdl.handle.net/10454/8120.
Повний текст джерелаPersonalised nutrition (PN) may promote public health. PN involves dietary advice based on individual characteristics of end users and can for example be based on lifestyle, blood and/or DNA profiling. Currently, PN is not refunded by most health insurance or health care plans. Improved public health is contingent on individual consumers being willing to pay for the service. Methods: A survey with a representative sample from the general population was conducted in eight European countries (N = 8233). Participants reported their will- 25 ingness to pay (WTP) for PN based on lifestyle information, lifestyle and blood information, and lifestyle and DNA information. WTP was elicited by contingent valuation with the price of a standard, non-PN advice used as reference. Results: About 30% of participants reported being willing to pay more for PN than for non-PN advice. They were on average prepared to pay about 150% of the reference price of a standard, non-personalised advice, with some differences related to socio-demographic factors. Conclusion: There is a potential market for PN 30 compared to non-PN advice, particularly among men on higher incomes. These findings raise questions to what extent personalized nutrition can be left to the market or should be incorporated into public health programs
EC (FW7) funded Food4me project
The full text will be available 12 months after publication
Furness, Denise Lyndal Fleur. "Genome damage and folate nutrigenomics in uteroplacental insufficiency." 2007. http://hdl.handle.net/2440/57508.
Повний текст джерелаhttp://proxy.library.adelaide.edu.au/login?url= http://library.adelaide.edu.au/cgi-bin/Pwebrecon.cgi?BBID=1309296
Thesis (Ph.D.) -- School of Paediatrics and Reproductive Health, 2007
Poinhos, R., der Lans I. A. van, A. Rankin, A. R. H. Fischer, B. P. Bunting, S. Kuznesof, Barbara Stewart-Knox, and L. J. Frewer. "Psychological Determinants of Consumer Acceptance of Personalised Nutrition in 9 European Countries." 2014. http://hdl.handle.net/10454/6721.
Повний текст джерелаObjective: To develop a model of the psychological factors which predict people’s intention to adopt personalised nutrition. Potential determinants of adoption included perceived risk and benefit, perceived self-efficacy, internal locus of control and health commitment. Methods: A questionnaire, developed from exploratory study data and the existing theoretical literature, and including validated psychological scales was administered to N = 9381 participants from 9 European countries (Germany, Greece, Ireland, Poland, Portugal, Spain, the Netherlands, the UK, and Norway). Results: Structural equation modelling indicated that the greater participants’ perceived benefits to be associated with personalised nutrition, the more positive their attitudes were towards personalised nutrition, and the greater their intention to adopt it. Higher levels of nutrition self-efficacy were related to more positive attitudes towards, and a greater expressed intention to adopt, personalised nutrition. Other constructs positively impacting attitudes towards personalised nutrition included more positive perceptions of the efficacy of regulatory control to protect consumers (e.g. in relation to personal data protection), higher self-reported internal health locus of control, and health commitment. Although higher perceived risk had a negative relationship with attitude and an inverse relationship with perceived benefit, its effects on attitude and intention to adopt personalised nutrition was less influential than perceived benefit. The model was stable across the different European countries, suggesting that psychological factors determining adoption of personalised nutrition have generic applicability across different European countries. Conclusion: The results suggest that transparent provision of information about potential benefits, and protection of consumers’ personal data is important for adoption, delivery of public health benefits, and commercialisation of personalised nutrition.
This project has received funding from the European Union’s Seventh Framework Programme for research, technological development and demonstration under grant agreement n u 265494 (http://cordis.europa.eu/fp7/home_en.html). Food4Me is the acronym of the project ‘‘Personalised nutrition: an integrated analysis of opportunities and challenges’’ (http://www.food4me.org/). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Rankin, A., S. Kuznesof, L. J. Frewer, K. Orr, J. Davison, Almeida M. D. V. de, and Barbara Stewart-Knox. "Public perceptions of personalised nutrition through the lens of Social Cognitive Theory." 2016. http://hdl.handle.net/10454/7761.
Повний текст джерелаSocial Cognitive Theory has been used to explain findings derived from focus group discussions (N = 4) held in the United Kingdom with the aim of informing best practice in personalised nutrition. Positive expectancies included weight loss and negative expectancies surrounded on-line security. Monitoring and feedback were crucial to goal setting and progress. Coaching by the service provider, family and friends was deemed important for self-efficacy. Paying for personalised nutrition symbolised commitment to behaviour change. The social context of eating, however, was perceived a problem and should be considered when designing personalised diets. Social Cognitive Theory could provide an effective framework through which to deliver personalised nutrition.
This work was supported by the European Commission under the Food, Agriculture, Fisheries and Biotechnology Theme of the 7th Framework Programme for Research and Technological Development (265494).
Abrahams, Mariëtte, L. J. Frewer, Eleanor J. Bryant, and Barbara Stewart-Knox. "Personalised nutrition technologies and innovations: A cross-national survey of registered dietitians." 2019. http://hdl.handle.net/10454/17245.
Повний текст джерелаBackground: Commercial technology-enabled personalised nutrition is undergoing 19 rapid growth, yet uptake in dietetics practice remains low. This survey sought the opinions 20 of dietetics practitioners on personalised nutrition and related technologies to understand 21 facilitators and barriers to its application in practice. 22 Method: A cross-section of Registered Dietitians were recruited in the US, UK, 23 Australia, Canada, Israel, Mexico, Portugal, Spain and South Africa. The questionnaire 24 sought views on risk of genetic technology, ethics of genetic testing, usefulness of new 25 personalised nutrition technologies, entrepreneurism and the perceived importance of 26 new technologies to dietetics. Validated scales were included to assess personality (Big 27 5) and self-efficacy (NGSEI). The survey was available in English, Spanish and 28 Portuguese. Regression analyses were performed to identify factors associated with 29 integration of nutrigenetic testing into practice, and to identify factors associated with the 30 perceived importance of bio, information and mobile technologies to dietetic practice. 31 Results: A total of 323 responses (response rate 19.7%) were analysed. Dietetic 32 practitioners who had integrated personalised nutrition technology into practice perceived 33 technologies to be less risky (P=0.02), biotechnology to be more important (P<0.01), and 34 professional skills to be less important (P=0.04) than those who had not. They were also 35 more likely to see themselves as entrepreneurs (P<0.01) and to perceive lower risks to be 36 associated with technology (P<0.01). Practitioners of nutrigenetics were lower on 37 neuroticism (P<0.01) and higher on self-efficacy (P<0.01), extraversion (P<0.01) and 38 agreeableness (P<0.01). Higher perceived importance of biotechnology to dietetic 39 practice was associated with higher perceived usefulness of omics tests (P<0.01). 40 Perceived importance of information technology was associated with perceived 41 importance of biotechnology (P<0.01). Mobile technologies were perceived as important 42 by dietitians with the highest level of education (P=0.02). 43 Conclusions: For dietitians to practice technology-enabled personalised nutrition, 44 training will be required to enhance self-efficacy, address risk perceived to be associated 45 with new technologies and to instil an entrepreneurial mindset.
Abrahams, Mariëtte, L. J. Frewer, Eleanor J. Bryant, and Barbara Stewart-Knox. "Factors determining the integration of nutritional genomics into clinical practice by registered dietitians." 2016. http://hdl.handle.net/10454/10682.
Повний текст джерелаPersonalized nutrition has the potential to improve health, prevent disease and reduce healthcare expenditure. Whilst research hints at positive consumer attitudes towards personalized nutrition that draws upon lifestyle, phenotypic and genotypic data, little is known about the degree to which registered dietitians (RD) are engaged in the delivery of such services. This review sought to determine possible factors associated with the integration of the emerging science of Nutritional Genomics (NGx) into the clinical practice setting by practicing registered dietitians. Scope Search of online databases (Pubmed; National Library of Medicine; Cochrane Library; Ovid Medline) was conducted on material published from January 2000 to December 2014. Studies that sampled practicing dietitians and investigated integration or application of NGx and genetics knowledge into practice were eligible. Articles were assessed according to the American Dietetic Association Quality Criteria Checklist. Key findings Application of nutritional genomics in practice has been limited. Reluctance to integrate NGx into practice is associated with low awareness of NGx, a lack of confidence in the science surrounding NGx and skepticism toward Direct to consumer (DTC) products. Successful application to practice was associated with knowledge about NGx, having confidence in the science, a positive attitude toward NGx, access to DTC products, a supportive working environment, working in the clinical setting rather than the public health domain and being in private rather than public practice. Conclusions There is a need to provide RGs with a supportive working environment that provides ongoing training in NGx and which is integrated with clinical practice.
Poínhos, R., B. Oliveira, der Lans I. A. van, A. R. H. Fischer, A. Berezowska, S. Kuznesof, Barbara Stewart-Knox, L. J. Frewer, and Almeida M. D. V. de. "Providing personalised nutrition: Consumers’ trust and preferences regarding sources of information, service providers and regulators, and communication channels." 2017. http://hdl.handle.net/10454/13280.
Повний текст джерелаBackground/Aims: Personalised nutrition has potential to revolutionise dietary health promotion if accepted by the general public. We studied trust and preferences regarding personalised nutrition services, how they influence intention to adopt these services, and cultural and social differences therein. Methods: A total of 9381 participants were quota sampled to be representative for each of nine EU countries (Germany, Greece, Ireland, Poland, Portugal, Spain, Netherlands, UK, Norway) and surveyed by questionnaire assessing their intention to adopt personalised nutrition, trust in service regulators and information sources, and preferences for service providers and information channels. Results: Trust and preferences significantly predicted intention to adopt personalised nutrition. Higher trust in the local department of healthcare was associated with lower intention to adopt personalised nutrition. General practitioners were the most trusted of service regulators, except for in Portugal, where consumer organisations and universities were most trusted. In all countries, family doctors were the most trusted information providers. Trust in the National Health Service as service regulator and information source showed high variability across countries. Despite its highest variability across countries, personal meeting was the preferred communication channel except in Spain (where an automated internet service was preferred). General practitioners were the preferred service providers, except in Poland, where dietitians and nutritionists were preferred. The preference for dietitians and nutritionists as service providers highly varied across countries. Conclusion: These results may assist in informing local initiatives to encourage acceptance and adoption of country specific tailored personalised nutrition services therefore benefiting individual and public health.
Macready, A. L., R. Fallaize, L. T. Butler, J. A. Ellis, S. Kuznesof, L. J. Frewer, C. Celis-Morales, et al. "Application of Behavior Change Techniques in a Personalized Nutrition Electronic Health Intervention Study: Protocol for the Web-Based Food4Me Randomized Controlled Trial." 2017. http://hdl.handle.net/10454/14283.
Повний текст джерелаIn order to determine the efficacy of behavior change techniques (BCT) applied in dietary and physical activity intervention studies, it is first necessary to record and describe techniques which have been used during such interventions. Published frameworks used in dietary and smoking cessation interventions undergo continuous development and most are not adapted for online delivery. The Food4Me study (N=1607) provided the opportunity to use existing frameworks to describe standardized online techniques employed in a large-scale internet-based intervention to change dietary behaviour and physical activity.
San-Cristobal, R., S. Navas-Carretero, C. Celis-Morales, K. M. Livingstone, Barbara Stewart-Knox, A. Rankin, A. L. Macready, et al. "Capturing health and eating status through a Nutritional Perception Screening Questionnaire (NPSQ9) in a randomised internet-based personalised nutrition intervention: the Food4Me study." 2017. http://hdl.handle.net/10454/13681.
Повний текст джерелаBackground: National guidelines emphasize healthy eating to promote wellbeing and prevention of non-communicable diseases. The perceived healthiness of food is determined by many factors affecting food intake. A positive perception of healthy eating has been shown to be associated with greater diet quality. Internet-based methodologies allow contact with large populations. Our present study aims to design and a short nutritional perception questionnaire, to be used as a screening tool for assessing nutritional status, and to predict an optimal level of personalisation in nutritional advice delivered via the Internet. Methods: Data from all participants who were screened and then enrolled into the Food4Me proof-of-principle study (n=2369) were used to determine the optimal items for inclusion in a novel screening tool, the Nutritional Perception Screening Questionnaire-9 (NPSQ9). Exploratory and confirmatory factor analyses were performed on anthropometric and biochemical data and on dietary indices acquired from participants who had completed the Food4Me dietary intervention (n=1153). Baseline and intervention data were analysed using linear regression and linear mixed regression, respectively. Results: A final model with 9 NPSQ items was validated against the dietary intervention data. NPSQ9 scores were inversely associated with BMI (β=-0.181, p<0.001) and waist circumference (Β=-0.155, p<0.001), and positively associated with total carotenoids (β=0.198, p<0.001), omega-3 fatty acid index (β=0.155, p<0.001), Healthy Eating Index (HEI) (β=0.299, p<0.001) and Mediterranean Diet Score (MDS) (β=0. 279, p<0.001). Findings from the longitudinal intervention study showed a greater reduction in BMI and improved dietary indices among participants with lower NPSQ9 scores. Conclusions: Healthy eating perceptions and dietary habits captured by the NPSQ9 score, based on 9 questionnaire items, were associated with reduced body weight and improved diet quality. Likewise, participants with a lower score achieved greater health improvements than those with higher scores, in response to personalised advice, suggesting that NPSQ9 may be used for early evaluation of nutritional status and to tailor nutritional advice.
European Union’s Seventh Framework Programme for 23 research, technological development and demonstration (grant agreement no. 265494). "la Caixa" Banking Foundation through a grant.
Μπαράκου, Αγλαΐα. "Υπηρεσίες διατροφογονιδιωματικής : απήχηση και κατανόηση του ρόλου τους από το ελληνικό κοινό". Thesis, 2012. http://hdl.handle.net/10889/5454.
Повний текст джерелаThis research constitutes a first attempt to understand the general public’s knowledge concerning basic notions and services in genetics-based nutrition, as well as reveal their attitudes and perceptions on Nutrigenomics. With this research we also aspire to assess the level of knowledge an interest of the general public in this field and evaluate their willingness to undergo such genetic analyses, in order to correlate their genetic profile with their nutrition and receive dietary recommendations. For the purposes of this study, we designed a questionnaire of 16 questions and conducted a general public survey. Our sample consists of 300 participants, randomly chosen from the public, in the city of Patras in Greece. The answers were analyzed by grouping them according to Gender, Age group and the BMI of the participants, in order to check for potential influence of these factors on the answers. Our analysis indicated that the public in Patras appears quite knowledgeable concerning DNA and the role of the genome in determining overall health. Participants also have a good grasp of the relation of nutrition to health conditions. A large proportion of the general public is aware of the existence of gene-based disorders and the potential benefits of genetic testing, although this proportion declines steadily with age. Our data revealed that only 9.7% of respondents from the general public had been advised to take a genetic test in order to explore the relationship between their genes and their nutritional status. However, 84% of them would be willing to undergo nutrigenomic analysis to correlate their genetic profile with their diet. Interestingly, to do so, the vast majority of the general public would prefer referral from a physician than from a dietitian/nutritionist. Our study has provided the first critical evaluation of the views of the general public with regard to genetics and genetic testing services in Greece and, since no other such study has been conducted so far, it should serve as a model for replication in other populations, so that we could target the groups that a) are in need of such analyses due to family history of obesity or cardiovascular disease, and b) are fundamentally scientifically aware and seem willing to undergo such tests.
Knoch, Bianca. "The effects of dietary eicosapentaenoic acid and arachidonic acid on gene expression changes in a mouse model of human inflammatory bowel diseases : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Nutritional Science at Massey University, Palmerston North, New Zealand." 2010. http://hdl.handle.net/10179/1529.
Повний текст джерелаGarofalo, Francesca. "Genetic Determinants of Plasma alpha-tocopherol." Thesis, 2012. http://hdl.handle.net/1807/35516.
Повний текст джерела