Дисертації з теми "Nucleoside Diphosphate Kinase (NDK)"
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SELLAM, OLIVIER. "La nucleoside diphosphate kinase des proprietes regulatrices pour une enzyme du metabolisme ? contribution a l'etude de la ndp kinase de dictyostelium discoideum." Paris 7, 1998. http://www.theses.fr/1998PA077149.
Повний текст джерелаMILON, LAURENCE. "La famille des nm23/ndp kinases humaines clonage de l'adnc, caracterisation biochimique et localisation mitochondriale de la nucleoside diphosphate kinase nm23-h4." Paris 6, 2000. http://www.theses.fr/2000PA066332.
Повний текст джерелаMassé, Karine. "Caractérisation des isoformes C et D de la NDP kinase chez la souris : étude préliminaire du rôle des isoformes A et B sur l'expression du protooncogène." Bordeaux 2, 1999. http://www.theses.fr/1999BOR28669.
Повний текст джерелаXU, YING-WU. "Crystallographique etude de nucleoside diphosphate kinase." Paris 11, 1998. http://www.theses.fr/1998PA112087.
Повний текст джерелаJohansson, Monika. "The role of nucleoside diphosphate kinase in plant mitochondria /." Uppsala : Dept. of Plant Biology and Forest Genetics, Swedish University of Agricultural Sciences, 2006. http://epsilon.slu.se/200674.pdf.
Повний текст джерелаHammargren, Jenni. "Novel functions of the mitochondrial nucleoside diphosphate kinase in plants /." Uppsala : Dept. of Plant Biology and Forest Genetics, Swedish University of Agricultural Sciences, 2007. http://epsilon.slu.se/200787.pdf.
Повний текст джерелаMorera, Solange. "Etude cristallographie de la nucleoside diphosphate kinase de dictyostelium discoideum." Paris 11, 1994. http://www.theses.fr/1994PA112251.
Повний текст джерелаMEYER, PHILIPPE. "Structure et fonction de la nucleoside diphosphate kinase : interaction avec les analogues de nucleoside antiviraux." Paris 11, 2000. http://www.theses.fr/2000PA112117.
Повний текст джерелаThomas, Simon. "Secretion of nucleoside diphosphate kinase by the parasitic nematode Trichinella Spiralis." Thesis, Imperial College London, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.405764.
Повний текст джерелаSchneider, Benoît. "Phosphorylation des analogues de nucleotides antiretroviraux par la nucleoside diphosphate kinase." Paris 6, 2001. http://www.theses.fr/2001PA066223.
Повний текст джерелаSharma, Rita. "Phosphorylation of chloroplast preproteins and the characterisation of nucleoside diphosphate kinase 2." Diss., [S.l.] : [s.n.], 2006. http://edoc.ub.uni-muenchen.de/archive/00005826.
Повний текст джерелаSun, Jim. "Role of Mycobacterium tuberculosis nucleoside diphosphate kinase in the pathogenesis of tuberculosis." Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/42000.
Повний текст джерелаWALLET, VALERIE. "Nucleoside diphosphate kinase de dictyostelium discoideum : clonage de l'adnc et etude biochimique de la proteine." Paris 6, 1992. http://www.theses.fr/1992PA066366.
Повний текст джерелаDabernat, Sandrine. "Création de souris transgéniques appliquée à l'étude de la nucléoside diphosphate kinase A." Bordeaux 2, 1998. http://www.theses.fr/1998BOR28625.
Повний текст джерелаErent, Murielle. "Nucléoside diphosphate kinases. Stabilisation de la protéine par la structure quaternaire." Bordeaux 2, 1997. http://www.theses.fr/1997BOR28510.
Повний текст джерелаGonin, Philippe. "Nucléoside diphosphate kinases : étude du mécanisme catalytique et utilisation comme domaine d'hexamérisation pour l'ingénierie des protéines." Bordeaux 2, 2000. http://www.theses.fr/2000BOR28815.
Повний текст джерелаMESNILDREY, SEBASTIEN. "Le role de la structure quaternaire de la nucleoside diphosphate kinase dans son activite catalytique et sa capacite a interagir avec les acides nucleiques." Paris 7, 1997. http://www.theses.fr/1997PA077251.
Повний текст джерелаFrançois-Moutal, Liberty. "Interactions protéines-membranes : conséquences sur l'état physique et l'organisation des lipides." Thesis, Lyon 1, 2013. http://www.theses.fr/2013LYO10062/document.
Повний текст джерелаNucleoside diphosphate kinase isoenzymes (NDPK) have been known for nearly 60 years and, until recently, have been considered as housekeeping enzymes. The discovery of a nme gene, an antimetastatic gene that codes for a NDPK, revived the interest for this family. It is now known that the multiplication of nme genes throughout evolution has been accompanied with structural and functional diversification. I studied the binding of NDPK-A, -B and –D (which ae retrieved associated to cellular membranes where they are thought to play several roles) to model membranes and found differences in their behavior towards different compositions of phospholipids. I showed the ability of the NDPKD mitochondrial isoform to interact with both anionic and zwitterionic membranes, to modify their fluidity and to form proteolipidic domains in presence of CL, a mitochondrial inner membrane specific anionic lipid. I observed this ability to form proteo-cardiolipin domains with other CL interacting protein like creatine kinase but not with cytochrome c. NDPK-A was not able to bind to inner leaflet plasma membrane mimicking systems suggesting another partner in vivo. Concerning NDPK-B, it interacted only with anionic membranes via a two step-process, induced a decrease of the membrane fluidity and was able to form proteolipidic domains. Such anionic lipid segregation triggered by protein binding may contribute to platforms formation within membranes. Those platforms are then susceptible to provide a functional docking platform for numerous molecules and thus to modulate cellular functions
Bhagavat, Raghu B. R. "Structural Bioinformatics of Ligand Recognition in Proteins : A large-scale Analysis and Applications in Drug Discovery." Thesis, 2017. http://etd.iisc.ac.in/handle/2005/4249.
Повний текст джерелаMishra, Saurabh. "Molecular Characterisation Of Mycobacterium Tuberculosis Fic Protein And Its Gene And Identification And Characterisation Of A Novel Functional Interaction Between FtsZ And NDK in Mycobacteria." Thesis, 2012. https://etd.iisc.ac.in/handle/2005/2530.
Повний текст джерелаMishra, Saurabh. "Molecular Characterisation Of Mycobacterium Tuberculosis Fic Protein And Its Gene And Identification And Characterisation Of A Novel Functional Interaction Between FtsZ And NDK in Mycobacteria." Thesis, 2012. http://etd.iisc.ernet.in/handle/2005/2530.
Повний текст джерелаHuang, Jen-Yen, and 黃任延. "Crstal Structure of Nucleoside Diphosphate Kinase in Rice." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/30353441657038710704.
Повний текст джерела國立清華大學
生命科學系
91
Crystal Structure of Nucleosie Diphosphate Kinase in Rice Nucleoside diphosphate kinase (NDK) is a ubiquitous enzyme found in all organisms (eukaryotes and prokaryotes) and cell type. It catalyses the transfer of the tpphosphoryl group from a nucleoside triphosphate (NTP) to a nucleoside diphosphate (NDP). NDK is involved and required for coleoptile elongation in rice. The level of the enzyme changes during seed germination and the early stages of seedling growth. Although several NDK structures from bacteria and animals have previously been available, the structures from plants are not yet determined. Crystals of the rice NDK have been obtained and several sets of data were collected at SPring-8 BL12B2 in Japan. The crystals belong to the space group P2(1)2(1)2(1) with unit-cell parameters a = 70.98 Å, b = 182.26 Å, c = 188.30 Å, and diffract to 2.5 Å. The structure is determined by molecular replacement method and shows the overall folding with four -sheets surrounded by six -helices. The model contains 149 residues of a total 152 residues and averaged 18 water molecules. Hexameric molecular packing in both crystals and solution implies the rice NDKs function as hexamers. In this study, we have determined the first rice NDK structure, which provides the detailed structural-functional information to understand the functional significance of this enzyme during plants growth and development in rice as well as plants.
Mitchell, Kimberly Ann Parrott. "Association of nucleoside diphosphate kinase with microtubule-based structures." 2008. http://proquest.umi.com/pqdweb?did=1805427661&sid=3&Fmt=2&clientId=3507&RQT=309&VName=PQD.
Повний текст джерелаChang, Yu-Chen, and 張瑜真. "Essential Role of Nucleoside Diphosphate Kinase NME3 on Mitochondrial Morphogenesis." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/z6h8vc.
Повний текст джерела國立臺灣大學
分子醫學研究所
107
The fission and fusion dynamics of mitochondria are crucial for their role in physiological processes and are precisely regulated. As protein machineries governing mitochondrial dynamics have been fully discovered, how lipids affect mitohcondrial morphology remains comparatively unclear. Highly conserved nucleoside diphosphate kinases are previously discovered as GTP fueling enzymes for dynamin superfamily proteins during membrane remodeling processes. Here we demonstrated that NME3 is required for mitochondrial morphology maintenance that depletion of NME3 caused mitochondrial fragmentation in C2C12 myoblast as well as in myotube. Surprisingly, a kinase-dead NME3 could still rescued this phenotype, yet the N-terminus truncated NME3 could not. Utilizing biochemical reconstitution experiments, we found NME3 directly binds to phosphatidic acid (PA) and functions as a mitochondrial tethering protein through the amphipathic helix formation and oligomeric architecture. Together my study proposes a function of amphipathic helix in organelle integrity maintenance and provides a mechanistic explanation for the role of PA in mitofusin-mediated mitochondrial fusion.
Tsao, Ning, and 曹甯. "The Contribution of CMP Kinase and Nucleoside Diphosphate Kinase 3 in DNA Repair." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/04750490829043069513.
Повний текст джерела國立臺灣大學
生物化學暨分子生物學研究所
103
Cellular supply of deoxynucleoside triphosphates (dNTPs) is crucial for DNA replication and repair. Ribonucleotide reducatse (RNR) is a rate-limiting enzyme for dNTP synthesis required for DNA repair, by reduction of four ribonucleoside diphosphates to generate corresponding dNDPs. In my thesis, the functional importance of UMP/CMP kinase (CMPK), an enzyme catalyzes (d)CDP formation and nucleoside diphosphate kinase 3 (NME3), one of ten isoforms of NME that converts (d)NDPs to (d)NTPs in DNA repair are demonstrated. Knockdown of CMPK delayed DNA repair after UV-irradiation in serum-deprived cells but had no effect on proliferating cells, while knockdown of NME3 declined DNA repair rate after doxorubicin exposure in proliferating cells. In addition, these two enzymes could form a complex with RNR and Tip60, a histone acetyltransferase by their N-terminal regions and recruited to DNA damages sites in a Tip60-depedent manner. The mutants of CMPK and NME3 with their N-terminal sequences deletion to eliminate their interaction with Tip60 also show the functional deficiency in DNA repair as compared to wild-type enzymes. I propose that the site-specific multienzyme complex formation provides a means for local synthesis of dNTPs to facilitate DNA repair in serum-deprived cells, which contain low cellular dNTP supply from cytosol. In addition to Tip60/RNR interaction for dNTPs supply at DNA damage sites, another function of NME3 in proliferating cells for DNA repair may involve the local production of ribonucleoside triphosphates (rNTPs).
Dharmasiri, Sunethra. "Molecular cloning and characterization of nucleoside diphosphate kinase in cultured sugarcane cells." Thesis, 1995. http://hdl.handle.net/10125/9478.
Повний текст джерелаAnn, Kyoungsook. "Cyclic GMP-dependent protein kinase and nucleoside diphosphate kinase from Paramecium tetraurelia biochemical and immunological studies /." 1991. http://catalog.hathitrust.org/api/volumes/oclc/25734262.html.
Повний текст джерелаTypescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 202-218).
Arumugam, Muthu. "Structural, Functional And Transcriptional Analysis Of Nucleoside Diphosphate Kinase From Mycobacterium Smegmatis mc2 155." Thesis, 2009. https://etd.iisc.ac.in/handle/2005/1338.
Повний текст джерелаArumugam, Muthu. "Structural, Functional And Transcriptional Analysis Of Nucleoside Diphosphate Kinase From Mycobacterium Smegmatis mc2 155." Thesis, 2009. http://etd.iisc.ernet.in/handle/2005/1338.
Повний текст джерелаDeng, Yu-Jyun, and 鄧伃君. "To investigate the role of nucleoside diphosphate kinase 3 (NME3) in DNA repair." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/13291767040510607537.
Повний текст джерела國立陽明大學
生化暨分子生物研究所
102
Deoxyribonucleic acid (DNA) is composed of four deoxynucleoside triphosphates (dATP, dTTP, dCTP, dGTP). The adequate intracellular dNTPs supply is crucial for DNA replication and repair. It has been reported that the rate-limiting enzyme of de novo pathway, ribonucleotide reductase(RNR) interacts with histone acetyltransferase 5 (Tip60) through R1 subunit, by which RNR is recruited to DNA damage sites. DNA repair needs dNTPs for material. dNDPs are generated by RNR, which required the coupling of nucleoside diphosphate kinase (NME) to complete dNTPs synthesis. There are 8 NME isoforms in human cells. In this study, I aimed to address whether NMEs are involved in DNA repair by forming complex with Tip60 and RNR. By using immunoprecipation, I identified NME3,NME4 and NME6 capable of interacting with Tip60. NME3 and NME4 complexes contain R2 subunit of endougenous RNR. Moreover, NME3 can form a complex with CMPK. Deletion analysis indicated that N-terminal extension fragment of NME3 is required for Tip60 complex formation, but not required for CMPK. By in vitro binding assay, I found that NME3 can directly interact with Tip60. Knockdown of NME3 reduces DNA repair efficiency during recovery from doxorubicin-induced DNA damage. Re-expression of wild type but not N-terminal deletion of NME3 restores the efficiency in DNA repair in NME3 knockdown cells. I proposed that complex formation of NME3 and Tip60 for dNTPs synthesis is critical for DNA repair.
Sharma, Rita [Verfasser]. "Phosphorylation of chloroplast preproteins and the characterisation of nucleoside diphosphate kinase 2 / vorgelegt von Rita Sharma." 2006. http://d-nb.info/981352340/34.
Повний текст джерелаMaheux, Emilie. "Caractérisation et étude de la régulation d’une isoforme cytosolique de peroxyrédoxine chez les solanacées." Thèse, 2012. http://hdl.handle.net/1866/9085.
Повний текст джерелаThe peroxiredoxins (PRXs) are a recently discovered family of peroxidases found in all organisms and ubiquitous in the cell. An important particularity of these proteins is the presence of one or two active cysteines that accomplish an oxydo-reduction cycle with an electron donor. The PRXs are sensitive to the redox potential and are implicated in the detoxification of the H2O2, an oxidante molecule induced in stress situations. The PRXs should be induced in stress situations and regulated by phosphorylation. Indeed, in vitro experimentations have shown that the NDPK1 can phosphorylate a cytosolic PRX isoform of the potato. This dissertation describes the experimentation made to acquire a preliminary understanding of the function of the PRX. For this purpose, we cloned a PRX isoform, followed by a biochemical characterization and expression studies of the protein. The sequencing data shown a type II PRX phylogenetically related to the cytosolic isoforms. The cDNA of this peroxiredoxin (PRX1) has been cloned in Solanum chacoense. The recombinant protein produced had a N-terminal (6xHis) tag. Enzymatic assays confirmed the antioxidant activity of the recombinant protein and a polyclonal antibody has been generated from the rabbit. This antibody was used in conjunction with an antibody anti-NDPK1 to determine the general expression patterns of those proteins during stresses in Solanum lycopersicum and Solanum tuberosum. The results obtained showed that the two proteins are generally co-expressed but not co-regulated. Obvious experimental facts displayed an induction of the PRX1 in biotic and abiotic stresses situations.
Ananvoranich, Sirinart. "Molecular cloning and characterization of flavonol sulfotranferase and nucleoside diphosphate kinase cDNA clones from Flaveria bidentis, and the regulation of flavonol 3-sulfotransferase in cell suspension cultures." Thesis, 1994. http://spectrum.library.concordia.ca/6163/1/NN01269.pdf.
Повний текст джерела