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Статті в журналах з теми "Nuclear modifi- cation factor"
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Sabirov, I. S., J. A. Murkamilova, A. I. Sabirova, I. T. Murkamilov, V. V. Fomin, and F. A. Yusupov. "Risk factors for cardiovascular complications in chronic kidney disease." Clinical Medicine (Russian Journal) 100, no. 9-10 (December 13, 2022): 432–38. http://dx.doi.org/10.30629/0023-2149-2022-100-9-10-432-438.
Повний текст джерелаАнотація:
Risk factors are constitutional peculiarity and human behavior that infl uence the disease development and / or pathological condition in the future. With regard to certain nosological units, including cardiovascular diseases, modifi able and nonmodifi able risk factors are distinguished. Non-modifi able risk factors for the development and progression of cardiovascular diseases include age, gender, and genetic predisposition, which are used to develop risk stratifi cation systems. These risk factors cannot be adjusted, ie. modifi ed, and can only be taken into account when determining the level of risk of diseases development. On the contrary, modifi able risk factors can undergo changes and be subdivided into behavioral and biological ones. Behavioral risk factors include: smoking, unhealthy diet, low physical activity, excessive alcohol consumption, chronic psycho-emotional stress. These behavioral risk factors in the lifestyle of a modern person are becoming more common in the conditions of urbanization, and contribute to the development of cardiovascular diseases. It should be noted that with longterm exposure to behavioral risk factors on the human body, biological risk factors are also formed: arterial hypertension, dyslipidemia, overweight, obesity, diabetes mellitus, chronic kidney disease.This review discusses the contribution of chronic kidney disease as a risk factor, as well as the mechanisms of formation and progression of cardiovascular diseases in kidney dysfunction.
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Kizilcan, Nilgun, and Merve Istif. "Novel comonomer synthesis from thiophene-2-carbonyl chloride and polydimethylsiloxane modified cyclohexanone formaldehyde resin." Pigment & Resin Technology 43, no. 5 (August 26, 2014): 277–84. http://dx.doi.org/10.1108/prt-07-2013-0055.
Повний текст джерелаАнотація:
Purpose – The purpose of this paper is to produce an electroactive monomer containing ketonic resins and then to investigate redox reaction between Fe+3 and bounded thiophene in comonomers. First, thiophene functionalised ketonic resins (Th-CFPDMSR) were synthesised by esterification reaction of thiophene-2-carbonyl chloride (ThCCl) and hydroxyl groups of cyclohexanone formaldehyde resin (CFR). Th-CFPDMSR was then polymerised by ferric salt. Thiophene modified ketonic resins (Th-CFPDMSR) as comonomers were characterised by common techniques such as gel permeation chromatography, proton nuclear magnetic resonance spectroscopy, Fourier transform infrared spectroscopy, differential scanning calorimeter and scanning electron microscope. Design/methodology/approach – Th-CFPDMSR comonomers were synthesised by esterification reaction of ThCCl and hydroxyl groups of ketonic resins. Then, the in-situ chemical oxidation (ISCO) of ThC-CFR in the presence of iron (III) chloride salt (FeCl3) was accomplished in chloroform/acetonitrile mixture solutions at room temperature. Findings – Important structural factor determined quantitatively for Th-CFPDMSR is the CFPDMS/TCCl ratio after reaction. The mole ratio effect of TCCl and ketonic resin on the solubility, molecular weight, melting temperature (Tm) and glass transition temperature (Tg) values of the comonomers (TCCl-CFPDMSR) was investigated. Research limitations/implications – The ferric ion (Fe+3) has a standard oxidation potential. Furthermore, FeCl3 can react with thiophene to produce a cation radical. FeCl3 cannot react with hydroxyl groups of ketonic resins. When ferric is used for ISCO application at relatively low temperatures (e.g. < 20°C), the oxidation reactions are usually less aggressive. Practical implications – This work provides technical information for the synthesis of conducting block copolymer and for the synthesis of chain-extended resins. The modified resins contain thiophene. The chemical oxidation system has been used to polymerise these thiophene groups, and resins with much higher molecular weight might be produced. The resins may also promote the adhesive strength of a coating and corrosion inhibition to metal surfaces of a coating. Originality/value – Novel Th-CFPDMSR comonomers were synthesised. These comonomers have higher Tg and Tm values than CF-PDMSR alone. The chemical oxidation system has been used to polymerise these thiophene functionalised ketonic resins.
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Doschechkina, Irina. "The role of scale factor in the formation of prod-uct properties under the action of surface modifi-cation." Bulletin of Kharkov National Automobile and Highway University, no. 94 (December 16, 2021): 97. http://dx.doi.org/10.30977/bul.2219-5548.2021.94.0.97.
Повний текст джерелаАнотація:
Based on theoretical and experimental research in the fields of solid-state physics and physical materials science, it is proved that the surface layer of a solid body, which is deformed, is an independent functional subsystem and radically affects large-scale levels of plastic flow and destruction of the product as a whole. As is known, the most effective method of improving the performance of products is the grinding of grain, because it is the grain boundary (substructural) mechanism of strengthening which provides an increase in the structural strength of the product. In this regard, special attention is paid to submicro- and nano-structuring of the surface. Goal. The aim of the work is to study the process of structure formation of the surface layer under the action of ion bombardment (IB) and its effect on the properties of products taking into account the scale factor. To achieve this goal, the following tasks were set: to evaluate the characteristics of the surface microstructure after IB and to study its tensile behavior in cylindrical and flat samples of low-carbon steel in order to take into account the scale factor in changing their properties. The submicro-structuring of the surface by ion bombardment is carried out in the work and its influence on the behavior of products during tensile deformation is investigated. It is established that the presence of a thin modified layer (with a constant core) significantly changes the properties of the product under force. The decisive role belongs to the contribution of the surface layer (scale factor) – the ratio of the area of the modified layer to the volume of the product: if it is <1 the effect of hardening is better realized while maintaining plasticity, and if ˃ 1, it is a significant effect of plasticization which maintains (or even increases) hardening.
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KOZHEVNIKOV, YURIY A. "APPLICATION OF MICROALGAE CHLORELLA VULGARIS BY LIVESTOCK BREEDING ENTERPRISES." Agricultural engineering, no. 5 (2021): 31–35. http://dx.doi.org/10.26897/2687-1149-2021-5-31-35.
Повний текст джерелаАнотація:
Industrial production of microalgae phytomass from agricultural waste for energy production purposes can solve the internal energy supply and environmental issues in the farm sector. The closed-cycle energy supply scheme is used in the livestock breeding facility to get hot water, feed additives to the cattle diet, biohumus, motor biofuels, and carbon dioxide, which is advisable to use in microalgae cultivation. The article presents a study of the experimental process of microalgae cultivation in a photobioreactor. The study goal was to determine the infl uence of technological conditions on the productivity of microalgae and obtain initial data for the development of closed cycles of using the energy potential of algamass in the heat and power supply of farm enterprises (e.g. dairy and poultry farms etc.). The authors carried out experiments using a photobioreactor for microalgae cultivation with an intelligent control system. The developed photobioreactor diff ers from the conventional variants by the pulsating hydrodynamic mode of feeding the nutrient solution. This modifi cation increases the productivity of microalgae cultivation by up to 15%. The cultivation conditions of Chlorella vulgaris microalgae on combined nutrition showed a noticeable increase in crop productivity when adding cattle manure extract in the amount of 30 to 60% (vol.) to the nutrient medium. This factor can be used to design closed cycles of the rmal and electrical supply of cattle farms based on third-generation biofuels obtained from microalgae phytomass.
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Saborowski, Michael, Gerd A. Kullak-Ublick та Jyrki J. Eloranta. "The Human Organic Cation Transporter-1 Gene Is Transactivated by Hepatocyte Nuclear Factor-4α". Journal of Pharmacology and Experimental Therapeutics 317, № 2 (25 січня 2006): 778–85. http://dx.doi.org/10.1124/jpet.105.099929.
Повний текст джерела
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Tsuji, Masamichi, and Sridhar Komarneni. "Alkali metal ion exchange selectivity of Al-substituted tobermorite." Journal of Materials Research 4, no. 3 (June 1989): 698–703. http://dx.doi.org/10.1557/jmr.1989.0698.
Повний текст джерелаАнотація:
Alkali metal ion exchange isotherms at a total ionic strength of 0.001 M were determined at 25 °C on a 1.13 nm anomalous [Al3+ + Na+]-substituted tobermorite with the formula, Ca5Na0.75Al0.9Si5.1O16(OH)2 · 6.03H2O. The Kielland plots of Na+/K+, Na+/Rb+, and Na+/Cs+ exchange reactions showed straight lines. The slopes were steeper for Cs+ and Rb+ exchange reactions, as compared to K+ exchange. The cation-exchange selectivity for alkali metals was found to increase as follows: Cs+>Rb+>K+>Na+. A new evaluation method of the separation factor (αMN/KMd/KNd,Kd: distribution coefficient) for a combination of two cations at infinite dilution was proposed in terms of the selectivity coefficient (KMNa) which can be easily determined from the Kielland plot. An extremely large separation factor for Cs (αCsNa = 112) was found at infinite dilution. These basic studies of cation exchange selectivity are of relevance in cation separation and purification and nuclear waste disposal.
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Kuznetsova, Svetlana O., Kristina A. Mustafina, and Marina V. Takmakova. "THE RELATIONSHIP OF BODY MODIFICATION AND SELF-HARMING BEHAVIOR WITH PSYCHOLOGICAL TRAUMAS EXPERIENCED IN CHILDHOOD." Вестник Пермского университета. Философия. Психология. Социология, no. 3 (2022): 479–93. http://dx.doi.org/10.17072/2078-7898/2022-3-479-493.
Повний текст джерелаАнотація:
This article presents the results of empirical research on the relationship between body modification and self-harming behavior on the one hand and psychological trauma in childhood on the other hand. The problem appears to be topical due to the frequent occurrence of self-harming behavior and the increasing popularity of body modification. The hypotheses of the study were as follows: the extent of body modifi-cation and self-harm are positively associated with psychological traumas experienced in childhood; psy-chological traumas associated with violence experienced in childhood show a stronger correlation with body modification and self-harm in adulthood, compared with other types of psychological traumas. The study involved 105 women and 71 men aged 16 to 50 years (the average age of women was 21.5, the av-erage age of men was 25.2). The survey and subjective scaling methods were used. The analysis of rela-tionships between the variables was carried out with the help of nonparametric methods. The nonparamet-ric Spearman coefficient was used to study the correlation. The intergroup comparison of scale estimates was performed using a one-factor analysis of variance. We obtained statistically significant weak positive correlations between the number of body modifications and the overall indicator of adverse life events. The number of body modifications is significantly positively associated with the experience of family psycho-traumatic events and violence. The self-harm rate is significantly positively associated with the overall indicator of adverse life situations, experience of family psycho-traumatic situations and violence. The coefficients of correlation between self-harm and adverse life situations turned out to be slightly higher compared to the correlation between body modifications and adverse childhood experiences. Cor-relation analysis showed a weak but significant positive relationship between self-harm and the number of body modifications. Significant differences in the indicator of psycho-traumatic events were found be-tween subgroups of respondents with and without piercings. Respondents with piercings demonstrate sig-nificantly higher rates on the general scale of adverse life events, on the scale of family psycho-traumatic situations, and the scale of psycho-traumatic events related to violence, compared with respondents with-out piercings. Regression analysis showed a significant correlation between the coefficient of self-harm and the gender factor, the factor of family psycho-traumatic events and psycho-traumatic events related to violence. This model explained 16.2% of the variance of the self-injury coefficient. The number of body modifications was significantly related only to the gender factor and the factor of psycho-traumatic events related to violence, which explained only 7.4% of the variance in the number of body modifications.
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Zhu, Lei, Xiao-Yan Qi, Lamine Aoudjit, Flaviana Mouawad, Cindy Baldwin, Stanley Nattel, and Tomoko Takano. "Nuclear factor of activated T cells mediates RhoA-induced fibronectin upregulation in glomerular podocytes." American Journal of Physiology-Renal Physiology 304, no. 7 (April 1, 2013): F849—F862. http://dx.doi.org/10.1152/ajprenal.00495.2012.
Повний текст джерелаАнотація:
Glomerulosclerosis is featured by accumulation of the extracellular matrixes in the glomerulus. We showed previously that activation of the small GTPase RhoA in podocytes induces heavy proteinuria and glomerulosclerosis in the mouse. In the current study, we investigated the mechanism by which RhoA stimulates the production of one of the extracellular matrixes, fibronectin, by podocytes, specifically testing the role of nuclear factor of activated T cells (NFAT). Expression of constitutively active RhoA in cultured podocytes activated the fibronectin promoter, upregulated fibronectin protein, and activated NFAT. Expression of constitutively active NFAT in podocytes also activated the fibronectin promoter and upregulated fibronectin protein. RhoA-induced NFAT activation and fibronectin upregulation were both dependent on the calcium/calmodulin pathway and Rho kinase. NFAT activation was also observed in vivo in the rat and mouse models of podocyte injury and proteinuria, and NFAT inhibition ameliorated fibronectin upregulation in the latter. RhoA activation induced a rise of intracellular calcium ion concentration ([Ca2+]i), which was at least in part dependent on the transient receptor potential canonical 6 (TRPC6) cation channel. The results indicate that RhoA activates NFAT by inducing a rise of [Ca2+]i in podocytes, which in turn contributes to fibronectin upregulation. This pathway may be responsible for the pathogenesis of certain glomerular diseases such as hypertension-mediated glomerulosclerosis.
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Kozlova, Marina M., Artem E. Bobylev, Larisa N. Maskaeva, Vyacheslav F. Markov, and Maxim I. Smolnikov. "Catalytic oxidation of cation exchanger KU-2×8 with an aqueous solution of hydrogen peroxide." Butlerov Communications 58, no. 5 (May 31, 2019): 54–61. http://dx.doi.org/10.37952/roi-jbc-01/19-58-5-54.
Повний текст джерелаАнотація:
During the operation of nuclear power plants, spent ion-exchange resins are formed, which are heterogeneous radioactive low-level waste in the form of particles from a cross-linked organic polymer. Such resins may not always be regenerated. Therefore, the disposal of spent ion exchange resins is currently one of the primary problems at nuclear power plants. Conventional technologies for the processing of waste resins are relatively expensive. In addition, there are difficulties with transportation and storage of waste, and the disposal of spent ion exchange resins is a complex process. In the present study, an attempt has been made to solve the problem of spent ion-exchange resins utilization on example of the sulfonic acid cation exchanger’s KU-2×8 oxidative degradation with the Fenton reaction. The decomposition of the cation exchanger was carried out with 20% hydrogen peroxide in the temperature range 323-353 K in the presence of a catalyst – low concentration copper(II) sulfate (0.001-0.009 mmol/l). The influence of process temperature and catalyst concentration on the reaction rate was estimated. When determining the rate of the cation exchanger KU-2×8 heterogeneous oxidation reaction with hydrogen peroxide in the presence of a catalytic additive, the spherical shape of the sorbent granules, the surface area of which changed during reaction, was taken into account. It was shown that with a reaction temperature increasing from 323 to 353 K, the rate constant of cation exchanger's oxidative decomposition have increased by a factor of 20-37. The activation energy values of the sulfonic acid cation exchanger's KU-2×8 decomposition with hydrogen peroxide in the presence of copper(II) sulfate are 89.7-115.2 kJ/mol, which indicates that the process is in the kinetic mode. It was established with electron-microscopic studies that the beads of the cation exchanger KU-2×8, when decomposed in H2O2 solution in the presence of a catalyst can stick together, change their shape and volume, and their surface becomes covered with cracks. The studies performed showed almost complete catalytic decomposition of cation exchanger KU-2×8 in a hydrogen peroxide solution at 323-353 K after 420-220 minutes, which allows accelerating the oxidation at relatively low temperatures.
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Kajiwara, Moto, Tomohiro Terada, Jun-ichi Asaka, Masayo Aoki, Toshiya Katsura, Iwao Ikai, and Ken-ichi Inui. "Regulation of basal core promoter activity of human organic cation transporter 1 (OCT1/SLC22A1)." American Journal of Physiology-Gastrointestinal and Liver Physiology 295, no. 6 (December 2008): G1211—G1216. http://dx.doi.org/10.1152/ajpgi.90360.2008.
Повний текст джерелаАнотація:
Human organic cation transporter 1 (OCT1/SLC22A1) plays important roles in the hepatic uptake of cationic drugs. The functional characteristics of this transporter have been well evaluated, but molecular information regarding transcriptional regulation is limited. In the present study, therefore, we examined the gene regulation of OCT1 gene focusing on basal core expression. An ∼2.5-kb fragment of the OCT1 promoter region was isolated, and promoter activity was measured by luciferase assay in the human liver cell lines Huh7 and HepG2. Deletion analysis suggested that the region spanning −141/−69 was essential for the basal core transcriptional activity and that this region contained the sequence of a cognate E-box (CACGTG). The E-box is known to be bound by the basal transcription factors, upstream stimulating factors (USFs), and the functional involvements of USF1 and USF2 were confirmed by a transactivation effect, a mutational analysis of the E-box, and an electrophoretic mobility shift assay. The transactivation effect of USFs on the OCT1 promoter was further stimulated by hepatocyte nuclear factor 4α, a liver-enriched transcription factor. There were no polymorphisms in the proximal promoter region (about 400 bp) of OCT1 gene ( n = 109). These findings indicated that both USF1 and USF2 bind to an E-box sequence located in the OCT1 core promoter region and are required for the basal gene expression of this transporter.
Дисертації з теми "Nuclear modifi- cation factor"
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Zhou, Xiaodan [Verfasser]. "Investigations on the effects of peroxisome proliferator-activated receptors and of nuclear factor kappa B on novel organic cation transporter 2 and carnitine uptake in bovine kidney cells / Xiaodan Zhou." Gießen : Universitätsbibliothek, 2014. http://d-nb.info/106859151X/34.
Повний текст джерелаТези доповідей конференцій з теми "Nuclear modifi- cation factor"
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Centner, Baudouin, and David Charpentier. "Spent Resin Hot Compaction at Tihange NPP." In 17th International Conference on Nuclear Engineering. ASMEDC, 2009. http://dx.doi.org/10.1115/icone17-75696.
Повний текст джерелаАнотація:
Spent ion exchange media are considered to be problematic waste that, in many cases, requires special approaches and precautions during their immobilization to meet acceptance criteria for disposal. Waste acceptance criteria define, among others, the quality of waste forms for disposal and therefore, will sometimes define appropriate treatment options. Furthermore, the Volume Reduction Factor is a key criterion in Belgium. A technical and economical comparison of industrially available systems, was performed by Tractebel Engineering, and led to decide the installation of a spent resin hot compaction unit at Tihange NPP. Tractebel Engineering is in charge of the project management and takes an active part in the process optimization. The Resin Hot Compaction Process mainly consists of the following steps: wet resin beads filling into a dryer – dewatering – mixing with a binding additive – drying under deep vacuum, until a residual water content of 4% – discharge of the dried waste into compactable drums – drum lid positioning – supercompaction at 1000 tons. In order to avoid cracks on the compacted drum, and surface external contamination from resin leaks, some optimization has been made about additive selection and drum design. Powdered cation exchange resins (as used for BWR condensate polishing) were found to be less compressible than common polymer powders, and to minimize springback as well as crack risks of the drum walls. Placing the compactable drum inside a second, slightly larger drum, also guarantees clean and reproducible pellets with a powder additive proportion limited to 25% of the total waste volume. Without this safety wrapping, the additive proportion must be raised to at least 30%. The obtained matrix inside pellets is a water free, solid but somewhat brittle block. Volume reduction factors between 1.8 and 1.9 are achieved. Special care must be taken about the mortar quality if pellets are to be grouted. This paper describes the Resin Hot Compaction Process application at Tihange NPP.
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Morris, Ronald. "Chemical Decontamination for Decommissioning (DFD) and DFDX." In ASME 2010 13th International Conference on Environmental Remediation and Radioactive Waste Management. ASMEDC, 2010. http://dx.doi.org/10.1115/icem2010-40007.
Повний текст джерелаАнотація:
DFD is an acronym for the “Decontamination for Decommissioning” process developed in 1996 by the Electric Power Research Institute (EPRI). The process was designed to remove radioactivity from the surfaces of metallic components to allow these components to be recycled or free-released for disposal as non-radioactive. DFD is a cyclic process consisting of fluoroboric acid, potassium permanganate and oxalic acid. The process continues to uniformly remove base metal once oxide dissolution is complete. The DFD process has been applied on numerous components, sub-systems and systems including the reactor systems at Big Rock Point and Maine Yankee in the United States, and the Jose Cabrera (Zorita) Nuclear Power Plant (NPP) in Spain. The Big Rock Point site has been returned to Greenfield and at Maine Yankee the land under the license was reduced for an Independent Spent Fuel Storage Installation (ISFSI). In the upcoming months the Zorita NPP in Spain will initiate dismantlement and decommissioning activities to return the site to a non-nuclear facility. The development of the EPRI DFD process has been an ongoing evolution and much has been learned from its use in the past. It is effective in attaining very high decontamination factors; however, DFD also produces secondary waste in the form of ion exchange resins. This secondary waste generation adds to the decommissioning quota but this can be improved upon at a time when radioactive waste storage at nuclear facilities and waste disposal sites is limited. To reduce the amount of secondary waste, EPRI has developed the DFDX process. This new process is an enhancement to the DFD process and produces a smaller amount of metallic waste rather than resin waste; this reduction in volume being a factor of ten or greater. Electrochemical ion exchange cells are the heart of the DFDX system and contain electrodes and cation ion exchange resin. It has been used very successfully in small system applications and the next evolution is to design, build and implement a system for the chemical decontamination for decommissioning of larger reactor systems and components, and Full System Decontamination (FSD). The purpose of this paper is to provide a reference point for those planning future chemical decontaminations for plant decommissioning. It is based on actual experience from the work already performed to date and the planned development of the DFDX process.