Дисертації з теми "NSF system"
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Golby, Jessica A. "Genetic analysis of Drosophila NSF function /." Thesis, Connect to this title online; UW restricted, 2003. http://hdl.handle.net/1773/10247.
Повний текст джерелаBoumenot, Christopher M. "The performance of a Linux NFS implementation." Link to electronic thesis, 2002. http://www.wpi.edu/Pubs/ETD/Available/etd-0523102-121726/.
Повний текст джерелаMuchie, M., and A. Baskaran. "Towards a Unified Conception of Innovation Systems." Tshwane University of Technology, 2010. http://encore.tut.ac.za/iii/cpro/DigitalItemViewPage.external?sp=1001626.
Повний текст джерелаDietrich, Hans. "Vergleich des Kreiskolbenmotors System NSU-Wankel mit dem Hubkolbenmotor." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2013. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-115035.
Повний текст джерелаMarshall, Chrissiejoy. "Yengarrahween Narrloo: Developing an Aboriginal dispute resolution program for NSW." Thesis, Indigenous Heath Studies, 1999. http://hdl.handle.net/2123/5691.
Повний текст джерелаAurikko, Jukka Petteri. "Structural studies of FGF and NGF signalling systems." Thesis, University of Cambridge, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.613132.
Повний текст джерелаMatinrad, Arash. "Design & development of an HSPA system simulator for network planning." Thesis, Linköpings universitet, Kommunikations- och transportsystem, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-69673.
Повний текст джерелаPhan, Kandy Q. "Design and implementation of NFS for a multilevel secure system." Thesis, Monterey, Calif. : Springfield, Va. : Naval Postgraduate School ; Available from National Technical Information Service, 2004. http://handle.dtic.mil/100.2/ADA422487.
Повний текст джерелаThesis Advisor(s): Cynthia E. Irvine, David J. Shifflett. "March 2004." Includes bibliographical references (p. 73-74). Also available in print.
Min, Bryan B. "Selection of disposal method for nuclear spent fuel : a plan for the application of the systems engineering process /." Master's thesis, This resource online, 1996. http://scholar.lib.vt.edu/theses/available/etd-02162010-020330/.
Повний текст джерелаAlghamedy, Fatemah. "ENHANCE NMF-BASED RECOMMENDATION SYSTEMS WITH AUXILIARY INFORMATION IMPUTATION." UKnowledge, 2019. https://uknowledge.uky.edu/cs_etds/79.
Повний текст джерелаSHA, Tim Wai. "Functional studies of Influenza A virus NS1 protein." Kyoto University, 2020. http://hdl.handle.net/2433/259078.
Повний текст джерелаDietrich, Hans [Verfasser]. "Vergleich des Kreiskolbenmotors System NSU-Wankel mit dem Hubkolbenmotor / Hans Dietrich." Dresden : Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2013. http://d-nb.info/1068152753/34.
Повний текст джерелаYalgashev, Olimjon. "Towards nanoscale interconnect for system-on-chip." Thesis, Belfort-Montbéliard, 2015. http://www.theses.fr/2015BELF0270/document.
Повний текст джерелаNanocommunication is a new paradigm that enables connectivity at the nanoscale through molecular, electromagnetic, acoustic, or nanomechanical mechanisms. The general context of this thesis concerns wireless nanosensor networks and nanonetworks on chips. More precisely, the thesis deals with interconnection architectures and communication protocols in the terahertz band. The existing network architectures and communication protocols should be revisited taking into account the communication mechanisms at the nanoscale.First, dissemination approaches in the context of wireless nanosensor networks are addressed. An efficient broadcasting approach is presented and the simulation performance results with Nano-Sim and NS3 show that the proposed scheme is superior to flooding, especially in the cases of excessive broadcasts.Second, we investigated the impact of transmission ranges on the performance of broadcast mechanisms based on electromagnetic waves at the nanoscale. Adaptive transmission range of electromagnetic-based communication approaches are proposed. Simulations are conducted with fixed and adaptive transmission ranges to show the efficiency of the proposed approaches in terms of throughput and latency according to the network density.The third part addresses the hypothesis of using EM-based nanonetwok as an on-chip interconnect for SoCs
Kratzsch, Alexander. "An Automated, Operating System-independent and Centralized Hardware Inventory : Keeping track of client computers in the NSA lab environment at the University of Skövde." Thesis, Högskolan i Skövde, Institutionen för informationsteknologi, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-11435.
Повний текст джерелаArsenio, Janilyn. "Development and application of a vaccinia virus based system to study viral proteins modulating interferon expression and interferon induced antiviral activities." Elsevier, 2008. http://hdl.handle.net/1993/5068.
Повний текст джерелаRizzi, Caterina. "NGF steers microglia toward a neuroprotective phenotype." Doctoral thesis, Scuola Normale Superiore, 2019. http://hdl.handle.net/11384/85996.
Повний текст джерелаBenedetti, Andrea. "A new method for continuous quality control of nsm cfrp systems." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2014. http://amslaurea.unibo.it/6835/.
Повний текст джерелаMay, Linda E. "Development of the Cardiac Beta-Adrenergic System in BAX and NGF Knockout Mice." Kent State University / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=kent1122136806.
Повний текст джерелаWilson-Salt, Anne-Marie. "NSW out-of-home care system: What is the problem represented to be?" Thesis, The University of Sydney, 2022. https://hdl.handle.net/2123/30038.
Повний текст джерелаHagberg, Mikael, Stefan Skedebäck, and Barlas Jonas Ramsin. "Jämförelse av nätverksfilsystemsprotokoll i Windowsmiljö." Thesis, University of Kalmar, School of Communication and Design, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:hik:diva-2060.
Повний текст джерелаDetta arbete handlar om nätverksfilsystemsprotokollen SMB/CIFS, SMB2 och NFSv3. Arbetet baseras på artikeln ”A New Network File System is Born: Comparison of SMB2, CIFS, and NFS” som skrivits av Steven M. French på IBM, Samba Team. I den artikeln saknas det prestandatester och därför känns det relevant att göra prestandatester för att få fram vilket protokoll som har högst hastighet med olika filstorlekar i Windowsmiljö. Dessa tester utfördes mellan två Dell PowerEdge 2900 servar där den första agerade som klient och den andra som filserver. Testerna utfördes en gång utan nätverksfördröjningar (även kallat latens/latency) och en gång med. Detta resulterade i att vi fick stora skillnader i hur snabba protokollen är med och utan nätverksfördröjningar.
This essay is about the networkfilesystem protocols SMB/CIFS, SMB2 and NFSv3. The work is based on the article ”A New Network File System is Born: Comparison of SMB2, CIFS, and NFS” which is written by Steven M. French at IBM, Samba Team. In the article there are no performance tests, we found it relevant to do performance tests to see which networkfilesystem protocol was the fastest with different filesizes in a Windows client environment. These tests were performed between two Dell PowerEdge 2900 servers where one of them was acting client and the other one fileserver. The tests were done once without network latency and once with. This resulted in that we got differences in how fast the protocols were with and without network latency.
CONVERTINO, Domenica. "Interfacing graphene with peripheral neurons: influence of neurite outgrowth and NGF axonal transport." Doctoral thesis, Scuola Normale Superiore, 2020. http://hdl.handle.net/11384/90468.
Повний текст джерелаIPPOLITO, VITA MARIA. "Mechanisms of glia-mediated neurodegeneration: modulation by Nerve Growth Factor (NGF) and the purinergic system." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2015. http://hdl.handle.net/10281/70478.
Повний текст джерелаThe objective of my thesis project was to understand mechanisms of neurodegeneration mediated by glial cells and characterize the molecular events involved in neuroprotection by Nerve Growth Factor (NGF). The interest in glial cells is based on the new concept of tripartite synapses and the existence of a bidirectional communication between neurons and astrocytes. For this study, we used a model of in-vitro reactive gliosis based on pure populations of astrocytes and/or microglia activated by Lipopolysaccharide (LPS) or the pro-inflammatory cytokine Tumor Necrosis Factor-α (TNFα). Initially, this system was used to study the effects of glial activation on astrocytes proliferation and evaluate the anti-gliosis activity of Nerve Growth Factor (NGF). Experiments of growth rate and BrdU incorporation showed that both LPS and TNFα determined a significant increase in astrocytes proliferation, which was reduced by co-treatment with NGF. At molecular level, we studied expression levels of NGF receptors: TrkA and p75. Our data indicated that treatments with LPS increased expression levels of p75 and decreased TrkA levels. This effect was prevented by co-treatment with NGF. We also studied the effects of glial activation on neuronal survival and functions by using a model of cortical neurons exposed to conditioned medium (CM) from activated astrocytes following treatment with LPS or TNFα. In fact, treatment with the CM from activated astrocytes decreased the survival of neurons and significantly reduced the levels of TrkA, but not in the presence of NGF. It was also seen that CM from glial cells activated with TNFα, induced a significant increase of ROS, that was completely inhibited by pre-incubation (ON) with NGF. A potential mechanism of toxicity may be mediated by pro-NGF (precursor of NGF), through the increase of metalloproteinase- 9 (MMP-9), the main protease responsible for maturation and degradation of NGF. RT-PCR analysis also led to the identification of a series of genes that participate to synaptic function and are down- or up-regulated by the treatment with CM and NGF. Finally, we assessed the effect of NGF on astrocytic mitochondrial function. Preliminary experiments, by Seahorse, indicated that NGF increased the respiratory capacity of astrocytes both in basal conditions and under stress conditions. In parallel, we studied the role of the purinergic system in neuroinflammation. Indeed, several studies have shown that activation of P2X7 receptors (a class of purinergic receptors), induces the secretion of pro-inflammatory cytokines and chemokines, such as TNFα, and also stimulates the production of superoxides in microglial cells. The effect of the purinergic system on glial activation was assessed by using OxATP, a P2X7 receptor antagonist. Our data showed that chronic co-treatment with OxATP significantly prevented the proliferation of astrocytes. Furthermore, treatment with OxATP had no effect on neuronal survival and astrocytes, but prevented the production of ROS. Finally, OxATP inhibited the decrease of astrocytic and neuronal vGLUT, the glutamate transporter, both in neurons and activated astrocytes. In conclusion, these studies identify two main mechanisms of glia-mediated neurodegeneration: one based on the alteration of neurotrophic support by NGF, the other due to activation of the purinergic system.
Lee, Lynette Ann. "Demand planning for specialist medical services for adults with intellectual disability in NSW 2003-2043." Thesis, The University of Sydney, 2015. http://hdl.handle.net/2123/14524.
Повний текст джерелаHermann, Everton. "Dinamismo de servidores de dados no sistema de arquivos dNFSp." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2006. http://hdl.handle.net/10183/7821.
Повний текст джерелаOne of the most important challenges to high performance systems designers is storing and transfering large amounts of data between the nodes on the system. Different approaches have been proposed to solve this storage performance problem. Cluster file systems, like PVFS, Lustre and NFSp are examples of such systems, as they distribute the functionality of a file system across the nodes of cluster, achieving a high level of parallelism and offering a larger storage space than centralized solutions. Usually the file system nodes are of two types: metadata servers and data servers. The placement of those services on a cluster is left to the cluster administrator. Such configuration is not an obvious task, as most file systems do not allow changing the configuration after the installation. A suboptimal initial configuration may result on a file system that does not fit the users need and changing such configuration may require a file system reinstall. The objective of this work is to propose a model to treat the dynamism of data servers on a cluster file system. Three scenarios were studied and for each one we have designed suitable reconfiguration strategies. The first case has its origin on the system administrator’s actions, adding or removing data servers to change the capacity of the file system. The tests have shown that with an homogeneous load distribution across the servers it was possible to obtain the best results. The second scenario treats the temporary data server insertion by the user. This case aims to provide extra storage capacity to a specified application. Tests were performed comparing applications with and without temporary data servers. On all the cases the application with temporary data server has had better performance results, reaching 20% of performance gain. The last scenario, combines replication techniqueswith server dynamism. Thisway, itwas possible to keep the file systemworking even on data servers failure. The tests have shown that the losts of a nodemay result on load unbalancing on data servers, degrading the overall file system performance.
Carroll, Brett. "Microbial and geochemical aspects of selenium cycling in an estuarine system Lake Macquarie, NSW /." Connect to full text, 1999. http://hdl.handle.net/2123/378.
Повний текст джерелаTitle from title screen (viewed Apr. 21, 2008). Submitted in fulfilment of the requirements for the degree of Doctor of Philosophy to the Dept. of Chemical Engineering, Graduate School of Engineering. Includes bibliography. Also available in print form.
Fishwick, Elaine. "When the stars align’: decision-making in the NSW juvenile justice system 1990-2005." Thesis, The University of Sydney, 2014. http://hdl.handle.net/2123/13250.
Повний текст джерелаGómez, Colom Javier. "Bond behaviour between CFRP and concrete for NSM systems under sustained loading." Doctoral thesis, Universitat de Girona, 2022. http://hdl.handle.net/10803/673911.
Повний текст джерелаDurant les últimes dècades, la rehabilitació d’estructures civils ha adquirit especial importància. Els materials compostos de fibra de carboni i matriu polimèrica (en anglès, Carbon Fibre Reinforced Polymers, CFRP) s’han introduït en el sector com a solució excel·lent per al reforç estructural de formigó armat, gràcies a les seves propietats mecàniques, la seva resistència a la corrosió i la seva lleugeresa. La tècnica del reforç inserit al recobriment (en anglès, Near-Surface Mounted, NSM) ha resultat ser una de les principals metodologies emprades gràcies a la protecció de l’FRP envers als agents externs. No obstant això, la durabilitat del reforç extern es pot veure afectada durant la seva vida útil, ja que les estructures es troben sotmeses a agents externs com càrregues sostingudes i temperatures cícliques degudes al cicle dia-nit. Per tal de dissenyar correctament el sistema de reforç i evitar fallades prematures per desenganxament del CFRP, és extremadament important estudiar com aquestes accions poden afectar a l’adherència entre el formigó i el reforç NSM CFRP. Aquesta tesi presenta un estudi del comportament de la unió adherida NSM CFRP-formigó des d’un punt de vista experimental i numèric. Inicialment, es va dissenyar una metodologia numèrica basada en un model de diferències finites per a predir la resposta global instantània de les unions adherides. Posteriorment, per a verificar el model numèric, es va realitzar una campanya d’assajos experimentals per estudiar l’adherència de la unió NSM CFRP-formigó a través d’assajos d’adherència fins a la ruptura. Es van assajar espècimens amb diferents valors d’amplada de regata i de longituds adherides per investigar l’efecte d’aquests paràmetres en la càrrega última i el mode de falla de la unió adherida. Mitjançant la metodologia numèrica, es va realitzar un estudi paramètric per investigar la influència dels principals paràmetres de la llei adherència-lliscament en la càrrega última i en la longitud d’adhesió efectiva de les unions adherides. A continuació, es va estudiar l’efecte de diferents temperatures de servei i nivells de càrrega sostinguda en la fluència de la unió adherida a través de (i) assajos d’adherència d’espècimens NSM CFRP-formigó i (ii) assajos a tracció d’espècimens d’adhesiu epòxid. Es va realitzar un total de cinc campanyes experimentals. Els espècimens es van assajar dins d’una cambra climàtica combinant tres nivells de càrrega sostinguda i diverses temperatures durant 1000 hores. Dels resultats experimentals es va observar que l’evolució de la deformació unitària (en adhesius) i de lliscament a l’extrem carregat (en espècimens NSM CFRP-formigó) augmentava a mesura que la temperatura mitjana de la cambra i el nivell de càrrega sostinguda augmentaven. Tot seguit, els espècimens sotmesos a assajos en servei es van assajar fins a ruptura per tal d’estudiar-ne la capacitat residual d’aquests. D’aquests assajos es va observar un decreixement general de les propietats mecàniques de les unions adherides (en termes de càrrega última i rigidesa) i dels espècimens d’adhesiu (en termes de resistència a tracció i mòdul elàstic). Finalment, el procediment numèric desenvolupat per a predir el comportament instantani de les unions adherides va ser adaptat per al càlcul del comportament a llarg termini de la unió NSM CFRP-formigó a partir de la implementació de la degradació de la llei adherència-lliscament amb el temps. Amb aquesta metodologia numèrica es va calcular l’evolució del lliscament a l’extrem carregat amb el temps per a cada configuració d’espècimen i es va fer la comparació amb el corresponent assaig experimental
Programa de Doctorat en Tecnologia
Yassine, Lobna. "Governing through ‘neutrality’: A Poststructural Analysis of Risk Assessment in the NSW Juvenile Justice System." Thesis, The University of Sydney, 2019. https://hdl.handle.net/2123/21228.
Повний текст джерелаLombard, Pierre. "NFSP : Une solution de stockage distribué pour architectures grande échelle." Phd thesis, Grenoble INPG, 2003. http://tel.archives-ouvertes.fr/tel-00004373.
Повний текст джерелаWittenby, Stephanie, and Mathilda Gunnarsson. "Skolans relevans för socialt arbete : En fallstudie om skolkonceptet NPF-säkring." Thesis, Linnéuniversitetet, Institutionen för socialt arbete (SA), 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-86203.
Повний текст джерелаRandolph, Christopher Lee. "REGULATION OF NEUROTROPHIN EXPRESSION IN PERIPHERAL TARGETS." Miami University / OhioLINK, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=miami1152646527.
Повний текст джерелаKim, Dal-Young. "The application of a PRRSV reverse genetic system for the study of nonstructural protein (nsp) function." Diss., Manhattan, Kan. : Kansas State University, 2007. http://hdl.handle.net/2097/317.
Повний текст джерелаNoronha, Ranjit Mario. "Designing High-Performance And Scalable Clustered Network Attached Storage With Infiniband." The Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=osu1218608130.
Повний текст джерелаJonsson, Lisa, and Karin Sallhammar. "User Interface Design for Analysis of Sensor Systems." Thesis, Linköping University, Department of Science and Technology, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1670.
Повний текст джерелаIn the future network-based Swedish Defence (NBD), attaining information superiority will be of great importance. This will be achieved by a network of networks where decision-makers, information- and weapon-systems are linked together. As a part of the development of NBD, we have performed a study of user interface design for a future network-based tool package for analysis of sensor systems, referred to as the C2SR-system.
This thesis was performed at Ericsson Microwave Systems AB, Sensor and Information Networks, during the autumn 2002. A pre-study concerning the requirements of usability, trustworthiness and functionality of a userinterface for the C2SR-system was performed. Officers representing the future users in the NBD played an important role when gathering these requirements. Another important part of the pre-study was the evaluation of software that contains parts of the functionality necessary for the C2SR-system.
On the basis of the results from the pre-study, we have designed a user interface to the future C2SR-system. To demonstrate the most important conclusions, a prototype was implemented.
Fyfe, Julian. "Performance evaluation of two dairy shed waste management systems in the Southern Highlands of NSW." Faculty of Engineering, 2004. http://ro.uow.edu.au/theses/387.
Повний текст джерелаPeyrouze, Nadine. "Conception et realisation d'un systeme de gestion de fichiers nfs efficace et sur de fonctionnement." Rennes 1, 1995. http://www.theses.fr/1995REN10118.
Повний текст джерелаSalazar, Ayala Olinda. "El sistema de detracciones del IGV y su influencia en la gestión financiera de la empresa NCF servicios compartidos S.A. año 2017." Bachelor's thesis, Universidad Ricardo Palma, 2018. http://cybertesis.urp.edu.pe/handle/urp/1420.
Повний текст джерелаKumža, Mantas. "RFID technologijų panaudojimas gamybos kokybės valdyme." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2007. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2007~D_20070816_144255-99814.
Повний текст джерелаManufactory industry is the most profitable sector of world’s market. Companies confronts with competitive market advantages to keep working successfully in continually changing market conditions. Therefore activities development strategies are created, new technologies are used in installation process, perfection of business control process, increasing quality of products, use of standards and quality requirements. The solution of these problems can be use of RFID (Radio Frequency Identification) technologies in manufacture management process. RFID is an automatic identification technology that relies on cheap tags (transponders) that can be attached to objects and storage information on it. The results of this project are RFID systems components witch can be used with other users applications such as „QMS“ (Quality Management Systems) of “RTech” company or other users applications. The successful integration of RFID technologies in manufacture quality management process can give effect in: • Automate and computerize manufacture quality management process; • Increase efficiency of product traceability system process; • Reduce rejects on product supply for consumer’s process. One of the master’s work goals is to evaluate the system, which was created in this work. The system can be improved by ISO standard models and made more flexible to use it for other works.
Alencar, JÃsy Maria Arruda de. "Seminal plasma proteomic and gene expression and ngf location and receptors (TRK1 and NGFR) in rabbit genital system." Universidade Federal do CearÃ, 2015. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=15600.
Повний текст джерелаThe aim this study were (i) to map and identify proteins in seminal plasma of New Zealand white rabbits strain, using the techniques of two-dimensional electrophoresis coupled to mass spectrometry and to estimate associations between these proteins with sperm parameters and (ii) characterize expression of the nerve growth factor polypeptide beta ( -NGF) and its cognate neurotrophic receptor tyrosine kinase type 1 (NTRK1), and nerve growth factor receptor (NGFR) at gonads and sex glands in adult New Zealand white rabbits as well as the NGF concentration in seminal plasma of sexually mature animals, using RT - PCR and immunohistochemistry. Also was measured the NGF concentration in the blood and seminal plasma by ELISA. Study 1 was performed at Federal University of CearÃ, in Fortaleza-Ce. Semen samples were collected from 18 adult rabbits, using an artificial vagina. After collecting proceeded to the evaluation of semen quality parameters: total motility, individual progressive motility, sperm concentration, sperm morphology and functional tests: membrane integrity (HOST), acrosomal integrity and vitality. The seminal plasma was obtained by centrifugation of semen, and subjected to two-dimensional electrophoresis. Gels were stained with colloidal Coomassie, scanned and analyzed in PDQuest application. The individual spots were excised from the gels, digested with trypsin, and submitted to mass spectrometry (ESI-QUAD-TOF) to identification. The results were subjected to statistical analysis to verify the existence of associations between the presence and / or intensity of the spots present in the protein maps of seminal plasma with the semen quality parameters. The associations between the parameters of ejaculated sperm and the expression of seminal plasma proteins of rabbits were estimated by multiple regression models using the REG procedure of SAS statistical application (v.9.0, 2002) with STEPWISE selection. 232  69.5 spots/gel were detected with 34 spots consistently present in all gels. These 34 spots corresponded to 15% of the total number of spots, representing 32% of the optical intensity of all the spots. Mass spectrometry identified approximately 95% of the detected spots (identified: 220 spots; analyzed: 232 spots), which corresponded to 87 different proteins. The most abundant proteins were the annexins, zeta-globin, lipocalin, FAM 115 protein and a serpins cluster. Other proteins also have been identified, such as transferrin, heat shock protein, glutathione transferase and others. The NGF (protein nerve growth factor) presence also has been identified which has been reported in other species such as ovulation induction factor. This 87 proteins identified in seminal plasma of rabbits participate mainly of biological processes associated with cellular processes (65.25%), regulation (64.25%) and response to stimuli (22.9%). Significant associations were observed between the proteins identified in seminal plasma of rabbits with sperm evaluated parameters such as individual progressive motility, sperm viability, cells with morphology and functional membranes have been associated with specific proteins. Associations were observed for several proteins with the same sperm parameter. According to literature, this is first report about the proteome of seminal plasma of rabbits and its role on the seminal parameters. Knowledge of these proteins contributes to a better understanding of the regulatory mechanisms of seminal plasma on sperm function in rabbits. Study 2 was conducted at Università Degli Studi di Perugia in the city of Perugia-Pe, Italy. It was evaluated the expression of NGF protein that was previously identified during study 1. The immunoreactivity and gene expression of NGF and cognate receptors were detected in testis, prostate and seminal vesicle. The highest levels of NGF and NTRK1 transcripts were found in prostate, while intermediate expressions were found in testis. NGFR transcripts were expressed at the same level on both the testis and prostate, and were more abundant than in seminal vesicles. The widespread distribution of NGF in all glandular cells of the prostate, coupled with its high abundance of mRNA on confirm that the prostate is a major source of this neurotrophin in rabbits. In conclusion, the present data suggest that NGF is involved in developmental system and spermatogenesis of testis rabbits and that NGF can act as a potential factor for induction of ovulation, being abundantly present in seminal plasma.
Os objetivos deste estudo foram (i) mapear e identificar as proteÃnas do plasma seminal de coelhos da raÃa Nova ZelÃndia Branca, utilizando as tÃcnicas de eletroforese bidimensional associada à espectrometria de massa e estimar associaÃÃes entre essas proteÃnas com os parÃmetros espermÃticos e (ii) caracterizar a expressÃo do fator de crescimento nervoso, poliptido beta ( -NGF), e os seus receptores cognatos neurotrÃficos da tirosina-quinase de tipo 1 (NTRK1) e receptor fator de crescimento nervoso (NGFR) nas gÃnadas e glÃndulas sexuais de coelhos da raÃa Nova ZelÃndia Branca, bem como as concentraÃÃes de NGF no plasma seminal de animais sexualmente maduros, utilizando as tÃcnicas de RT - PCR e imunohistoquÃmica. TambÃm foi dosada a concentraÃÃo da NGF no sangue e no plasma seminal atravÃs da tÃcnica de ELISA. O estudo 1 foi realizado na Universidade Federal do CearÃ, na cidade de Fortaleza-Ce. Foram coletados amostras de sÃmen de 18 coelhos adultos, utilizando- se uma vagina artificial. ApÃs a coleta procedeu-se a avaliaÃÃo dos parÃmetros qualidade seminal: motilidade, vigor, concentraÃÃo espermÃtica, morfologia espermÃtica e os testes funcionais: integridade de membrana, integridade acrossomal e vitalidade. O plasma seminal foi obtido pela centrifugaÃÃo do sÃmen, e submetido à eletroforese bidimensional. Os gÃis foram corados com Coomassie coloidal, digitalizados e analisados no aplicativo PDQuest. Os spots foram cortados individualmente dos gÃis, digeridos com tripsina, e submetidos à identificaÃÃo por espectrometria de massa (ESI- QUAD-TOF). Os resultados obtidos foram submetidos a avaliaÃÃo estatÃstica para verificar a existÃncia de associaÃÃes entre entre a presenÃa e/ou intensidade dos spots presentes nos mapas protÃicos do plasma seminal com os parÃmetros de qualidade seminal. As associaÃÃes entre os parÃmetros dos espermatozoides ejaculados e a expressÃo das proteÃnas do plasma seminal dos coelhos foram estimadas por modelos de regressÃo mÃltipla usando o procedimento REG do aplicativo estatÃstico SAS (v.9.0, 2002) com a seleÃÃo STEPWISE. Foram detectados 232  69,5 spots protÃicos por gel, com 34 spots presentes consistentemente em todos os gÃis. Esses 34 spots corresponderam a 15 % do total do nÃmero de spots, representando 32 % da intensidade Ãptica de todos os spots. A espectometria de massa identicou aproximadamente 95% dos spots detectados (220 spots de um total de 232), que corresponderam a 87 proteÃnas diferentes. As proteÃnas mais abundantes foram as anexinas, zeta-globina, lipocalinas, proteina FAM 115 e um grupamento de serpinas. Outras proteÃnas tambÃm foram identificadas, tais como: transferrina, heat shock protein, glutationa transferase, entre outras. TambÃm foi identificada apresenÃa da proteÃna fator de crescimento nervoso (NGF) que tem sido relatada em outras espÃcies como fator de induÃÃo à ovulaÃÃo. As 87 proteÃnas identificadas no plasma seminal de coelhos participam principalmente dos processos biolÃgicos associados a processos celulares (65,25 %), regulaÃÃo (64,25 %) e resposta a estÃmulos (22,9 %). Foram observadas associaÃÃes significativas entre as proteÃnas identificadas no plasma seminal de coelhos com os parÃmetros espermÃticos avaliados,tais como vigor, nÃmero de cÃlulas viÃveis, morfologia espermÃtica e cÃlulas com membranas funcionais foram associados com proteÃnas especÃficas. Foram observadas associaÃÃes de vÃrias proteÃnas com um mesmo parÃmetro espermÃtico. De acordo com a literatura, este representa o primeiro relato sobre o proteoma do plasma seminal de coelhos e seu papel sobre os parÃmetros seminais. O conhecimento dessas proteÃnas contribuirà para uma melhor compreensÃo dos mecanismos de regulaÃÃo do plasma seminal sobre a funÃÃo espermÃtica em coelhos. O estudo 2 foi conduzido na Università Degli Studi di Perugia, na cidade de Perugia-Pe, ItÃlia. Foi avaliada a expressÃo da proteÃna NGF que foi previamente identificada no estudo 1. A imunorreatividade e a expressÃo gÃnica da NGF e os seus receptores cognatos foram detectados nos testÃculos, prÃstata e vesÃcula seminal. Os nÃveis mais elevados de NGF e NTRK1 transcritos foram encontrados na prÃstata, enquanto expressÃes intermediÃrias foram encontradas no testÃculo. NGFR transcritos foram expressos nos mesmos nÃveis em ambos os testÃculos e da prÃstata e eram mais abundantes do que nas vesÃculas seminais. A distribuiÃÃo generalizada de NGF em todas as cÃlulas glandulares da prÃstata, juntamente com a sua abundÃncia de RNAm relativo, confirmam que a prÃstata à das principais fontes desta neurotrofina em coelhos. Em conclusÃo, os presentes dados sugerem que o sistema NGF està envolvido no desenvolvimento testicular e espermatogÃnese de coelhos e que o NGF pode atuar como um potencial fator de induÃÃo à ovulaÃÃo, sendo abundantemente presentes no plasma seminal.
Barreto, Linara Souza da Costa. "Shell para desenvolvimento de sistemas especialistas na área de saúde." Universidade Federal do Amazonas, 2007. http://tede.ufam.edu.br/handle/tede/4467.
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CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
The expert systems are computational tools built from argument of strong methods in artificial intelligence. This argument states that the resolution of complex problems is only possible when specific knowledge of the nature of the problem to be solved is known. The construction of expert systems in addition to be a very complex task involves a precious expenditure of time. Due to this, there are tolls called Shell that allow rapid prototyping of an expert system, demonstrating or not the viability of a Integral System construction. In this work, the main concern was to develop a Shell that was used with priority, but not exclusively, to diagnosis applications in medicine. In this sense, the system has been provided with the ability to handle linguistic data, data like image and numeric interval data (expressed by ranges of values: a x b). The possibility of working with numerical interval data and with multivalued variables is the main difference between Shell proposed in this work compared to other publications found in literature. In order to be possible to deal with interval data, a specific inference algorithm that incorporates an unification algorithm was developed. It has been given to the system the treatment of uncertainty through certainty factors. There is the possibility of working with multiples targets simultaneously. In the results, an original system was developed for atherosclerosis diagnostics that uses rules with interval variables and a system for AIDS treatment that uses multivalued variables. Moreover, the uncertainty treatment in the Shell proposed is compared with the uncertainty treatment in two other systems nationally developed. As a conclusion, the great application of the proposed system is highlighted, which allows the diagnosis in areas so varied that ranges from radiology to laboratory diagnosis.
Os sistemas especialistas são ferramentas computacionais construídas a partir do argumento dos métodos fortes em inteligência artificial. Esse argumento afirma que a resolução de problemas complexos só é possível quando se dispõem de conhecimentos específicos sobre a natureza do problema a ser resolvido. A construção dos sistemas especialistas, além de ser uma tarefa assaz complexa, envolve o dispêndio de tempo. Devido a isso, dispõe-se de ferramentas denominadas de Núcleo de Sistemas Especialistas (NSE) ou Shell, que permitem a prototipagem rápida de um Sistema Especialista, demonstrando ou não a viabilidade da construção de um Sistema Integral. Neste trabalho, a principal preocupação foi desenvolver um NSE que fosse utilizado de forma prioritária, mas não exclusiva, para aplicações diagnósticas em medicina. Nesse sentido, dotou-se o sistema da capacidade de lidar com dados literais, dados tipo imagem e dados numéricos intervalares (dados expressos por meio de faixas de valores: a x b). A possibilidade de trabalhar com dados numéricos intervalares e com variáveis multivaloradas é o principal diferencial entre o NSE proposto neste trabalho em relação a outras publicações. Para tornar possível o tratamento de dados intervalares, desenvolveu-se um algoritmo de inferência próprio que incorpora algoritmo de unificação também original. Dotou-se o sistema de um tratamento da incerteza por meio de fatores de certeza. Existe a possibilidade de trabalhar-se com múltiplas metas simultaneamente. Nos resultados, desenvolveu-se um sistema original para diagnóstico da aterosclerose que utiliza regras com variáveis intervalares, um sistema para tratamento da AIDS que utiliza variáveis multivaloradas. Compara-se, outrossim, o tratamento da incerteza no NSE proposto com o tratamento da incerteza em outros dois sistemas desenvolvidos nacionalmente. Como conclusão, destaca-se o amplo espectro de aplicações do sistema proposto, que permite o diagnóstico em áreas tão variadas que vão desde a radiologia à diagnóstico com dados laboratoriais.
Pelissier-Rota, Marjolaine. "Le stress et les maladies inflammatoires cryptogénétiques de l'intestin (MICI) : rôle anti-inflammatoire de la neurostimulation vagale (NSV)." Thesis, Grenoble, 2014. http://www.theses.fr/2014GRENV057/document.
Повний текст джерелаInflammatory Bowel Disease (IBD) patients, such as Crohn's disease or ulcerative colitis suffer from chronic and relapsing intestinal inflammation that favours the development of colitis associated cancer (CAC). This inflammation is initiated by aberrant activations of the innate immune responses associated to intestinal barrier defects. The conventional medical therapies consist to decrease the inflammatory response, which also decrease the risk of colon carcinoma but lead to severe side-effects. Recently, a number of animal studies have demonstrated that innate immune responses are attenuated by stimulation of the efferent arm of vagus nerve (VN) through its neurotransmitter acetylcholine (ACh) that acts on resident macrophages α7 nicotinic receptor (α7 nAChR). ACh also acts as a signalling molecule in epithelial cells through cholinergic receptors such as nAChR or muscarinic (mAChR) receptors. In the current study, we aimed to extend these findings to CAC prevention by treating human adenocarcinoma cell lines through targeting cholinergic receptors with nicotine (which binds nAChR) and ACh (which binds both cholinergic receptors). Using HT-29 and Caco-2 cell lines, we demonstrated that ACh-induced activation of mAChR results in cell dissociation together with changes in expression and localization of intestinal tight and adherens junction proteins. ACh-induced modulation of cell adhesion proprieties correlates with the acquisition of invasive potential. By contrast, nicotine-mediated activation of nAChR maintains epithelial cell organisation. ACh-released by VN stimulation (VNS) could effectively preserve epithelium integrity thus limiting inflammatory response and tumor development. However, attention should be paid on the nature of the cholinergic receptor solicited. Indeed, regarding to the protective effects of nAChR signalling on epithelial cells, activation of mAChR would worsen the disease and led to increase inflammation. These data have important repercussions on the therapeutic potential of VNS in IBD and CAC, which may represent “the yin and yang” of the intestinal homeostasis
Marshall, Christine Louise. "The role of APPRAISAL in the National Research Foundation (NRF) rating system evaluation and instruction in peer reviewer reports." Thesis, Rhodes University, 2010. http://hdl.handle.net/10962/d1002638.
Повний текст джерелаKalayci, Ahmet Serhat. "Development of Surface Flaw Thresholds for Pre-Cured Fiber Reinforced Polymer and Groove Size Tolerance for Near Surface Mounted Fiber Reinforced Polymer Retrofit Systems." FIU Digital Commons, 2008. http://digitalcommons.fiu.edu/etd/21.
Повний текст джерелаMontero-Menei, Claudia. "Reparation du systeme cholinergique septo-hippocampique lese : etude et caracterisation du role du nerve growth factor (ngf)." Paris 7, 1991. http://www.theses.fr/1991PA077190.
Повний текст джерелаJones, Elizabeth Ellen. "NEUROTROPHIN EXPRESSION IN SYMPATHETIC NEURONS: INFLUENCES OF EXOGENOUS NGF AND AFFERENT INPUT." Oxford, Ohio : Miami University, 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=miami1089903903.
Повний текст джерелаPierce, Suzanne Marie. "Expectations and experience of complaints and notifications about registered health professionals in the Australian national and NSW regulatory systems: A comparative study of complaints and notifications from the perspective of ‘system users’." Thesis, The University of Sydney, 2017. http://hdl.handle.net/2123/17985.
Повний текст джерелаPrachomrat, Pattamaporn. "Public sector R&D and innovation in an emerging country : an analysis of knowledge flow between public and private sectors in the Thai National System of Innovation." Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/33115.
Повний текст джерелаVerrell, Andrew George. "Water, nitrogen, crown rot and common root rot interact to limit wheat production in northern NSW cropping systems." Thesis, The University of Sydney, 2004. https://hdl.handle.net/2123/27955.
Повний текст джерелаSakala, Peter. "Laboratorní scénáře popisující systém DNS." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2018. http://www.nusl.cz/ntk/nusl-377122.
Повний текст джерелаLacheiner, Karen. "Tubules composed of non-structural protein NS1 of african horsesickness virus as a system for the immune display of foreign peptides." Pretoria : [s.n.], 2006. http://upetd.up.ac.za/thesis/available/etd-07092008-103908.
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