Дисертації з теми "Nse4"
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Diaz, Smoje Mariana Andrea [Verfasser], and George [Gutachter] Coupland. "Functional characterization of NSE4 paralogs in Arabidopsis thaliana / Mariana Andrea Diaz Smoje ; Gutachter: George Coupland." Köln : Universitäts- und Stadtbibliothek Köln, 2018. http://d-nb.info/1160379386/34.
Повний текст джерелаZelkowski, Mateusz [Verfasser]. "Arabidopsis NSE4 proteins act in somatic nuclei and meiosis to ensure plant viability and fertility / Mateusz Zelkowski." Halle, 2019. http://d-nb.info/117779859X/34.
Повний текст джерелаHu, Bin. "Functional analysis of the middle domain of Hsp90, and characterisation of QR12/NSE4, an essential cell cycle gene that is found in an Hsp90 complex." Thesis, King's College London (University of London), 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.424460.
Повний текст джерелаGibbons, Thomas Field. "Rotavirus NSP4 in extrareticular sites: support for its pathogenic role as an enterotoxin." Diss., Texas A&M University, 2007. http://hdl.handle.net/1969.1/85890.
Повний текст джерелаYang, Weiming. "Functional studies of the group A rotavirus non-structural protein NSP4." Thesis, University of Warwick, 2010. http://wrap.warwick.ac.uk/35683/.
Повний текст джерелаKrohn, Michael. "Immunhistochemische Untersuchungen mittels S100 und NSE nach Schädel-Hirn-Trauma." Doctoral thesis, Universitätsbibliothek Leipzig, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-189289.
Повний текст джерелаDe, La Torre Sousa César Augusto, Navarro Catherine Vanessa Figueroa, Rios Carlos Flavio Huamaní, and Rodríguez César Oswaldo Ramírez. "Factores críticos del sector inmobiliario para incursionar del NSE A y B al NSE C y D de Lima Metropolitana." Master's thesis, Pontificia Universidad Católica del Perú, 2013. http://tesis.pucp.edu.pe/repositorio/handle/123456789/8696.
Повний текст джерелаLa investigación se centra en conocer los factores críticos para incursionar en el sector inmobiliario con departamentos en los niveles socioeconómicos (NSE) C y D para que promotores-constructores de pequeñas empresas de Lima Metropolitana, quienes actualmente construyen para los NSE A y B, puedan enfocar sus ventas en dichos niveles socioeconómicos. El conocimiento de los factores críticos, la identificación del tipo de mindset de un grupo de promotores-constructores entrevistados de pequeñas empresas y la propuesta de un tipo de departamento para incursionar en sectores populares ayudarán a solucionar en parte la problemática de aquellos promotores-constructores que no pueden dirigirse a los NSE C y D con proyectos masivos, permitiendo que estas empresas tengan mayores posibilidades de ampliar sus mercados y aprovechar las oportunidades que presenta la coyuntura inmobiliaria donde la demanda de viviendas en dicho sector sigue creciendo y la oferta actual no es suficiente. La investigación es del tipo exploratorio y ha utilizado un enfoque cualitativo. La muestra de promotores-constructores fue no probabilística, bajo el tipo experto y homogéneo. Los datos fueron recolectados de entrevistas en profundidad con una guía de preguntas que se indican en el capítulo 3. Las respuestas han sido grabadas y transcritas con la autorización de los entrevistados. Para procesar la información, se usó como herramienta el software Atlas TI, el cual permitió agrupar las respuestas de cada entrevistado ordenándolas de acuerdo con la antigüedad en el negocio. Los resultados indican que los factores críticos son cinco: parámetros urbanísticos del distrito, respaldo económico, importancia en la compra del terreno, optimización de los costos en la construcción y experiencia del promotor. Asimismo, se infiere que el tipo de mindset predominante en el grupo de promotores-constructores entrevistados es del tipo no empresarial, constringente y colectivo. III A partir de estos resultados, se construye un gráfico (mapa mental) de la relación entre los factores críticos y el tipo de mindset, para luego generar cuatro proposiciones que explica la relación del factor parámetros urbanísticos con el tipo de mindset fixed. Asimismo, el de los factores respaldo económico, compra de terreno y experiencia del promotor con el tipo de mindset constringente, y el del factor optimizar costos en construir con el tipo de mindset no empresarial. Sobre la alternativa de un tipo de departamento para incursionar en los NSE C y D en forma no masiva, se propone departamentos tipo loft, al ser un ambiente con pocos muros y espacios integrados de acuerdo con lo mencionado en el capítulo 2. El loft permite optimizar los costos de construcción, que es uno de los factores críticos identificados. Esta propuesta de vivienda puede dirigirse a los siguientes grupos sociales de los NSE C y D: (a) jóvenes profesionales y estudiantes universitarios; (b) personas con estilo de vida del tipo emprendedores y sensoriales, seleccionado de Arellano (2003); (c) hogares con pocos integrantes como los del tipo partida, tipo inicio y tipo fuera de ciclo, tomado de Ipsos Apoyo (2012); y (d) inversionistas. Las ventajas de ofrecer departamentos tipo loft para los NSE C y D son: (a) ampliación del negocio, al captar un público objetivo cuya demanda de vivienda no es atendida; y (b) al ser un departamento de transición, se podría construir mayor número de ambientes de uno o dos dormitorios para un público objetivo específico
The research is focused on identifying the critical factors to invest in real estate with apartments designed for socioeconomic status C and D so order that the developers-builders, which belong to small companies of Lima Metropolitan, who currently build for socioeconomic status A and B wil focus their sales in socioeconomic status C and D. Identifying the critical factors, finding the type of mindset of the group of developersbuilders, which compose the research sample, and proposing a type of housing, mainly apartments, to move into popular sectors, will help party to solve the problems of those developers-builders who currently can not address the socioeconomic status C and D with massive projects, allowing these companies to have greater opportunities to expand their markets and take advantage of opportunities presented by the real estate situation where the demand for housing in said sectors continues to grow and the current supply is not sufficient. The research is exploratory and uses a qualitative approach. The developers-builders sample was not random under the expert and homogeneous type. Data were collected from interviews with a guide of questions listed in Chapter 3. The responses were recorded and transcribed with the permission of the interviewees. In order to process the data we used a software tool called Atlas TI which allowed us to group the responses of each interviewee according to their years of experience in the business. The results showed five critical factors: zoning parameters of the districts, economic support, importance of the land purchase, optimization of construction cost and the developer´s experience. Also, it seems that the type of mindset prevalent in the group of developers-builders is the non-business, constricting and collectivistic type. From these results we built a graphical map of the relationship between the critical factors and the type of mindset, in order to generate four proposals that will explain, for instance, the relationship among the zoning parameters of districts, the fixed mindset, the V economic support, the important of the land purchase and developer´s experience with the constricting mindset, and finally the optimization of construction cost with the non-business mindset. The type of housing proposed to venture into socioeconomic status C and D in a nonmassive way will be the loft apartment since it implies few walls and integrated spaces as mentioned in Chapter 2. The loft apartment allows optimizing construction costs, which is one of the critical factors identified. The target market for this type of housing in the socioeconomic status C and D will be: (a) young professionals and college students, (b) people with an enterprising and sensorial lifestyle, according to author Arellano (2003), (c) households with few members such as departure type, initiation type and off-cycle type, taken from Ipsos Apoyo (2012), and (d) investors. The advantages of offering loft apartments for socioeconomic status C and D are: (a) business expansion identifying a target audience whose housing demands are not satisfied, and (b) building a higher number of one or two-bedroom apartments for a specific target audience
Tesis
Mir, Kiran D. "The rotavirus nonstructural protein 4 (NSP4) interacts with both the N- and C- termini of caveolin-1." Texas A&M University, 2003. http://hdl.handle.net/1969.1/3976.
Повний текст джерелаUlrich, Anett. "S100B-Protein und Neuronenspezifische Enolase bei leichten Schädel-Hirn-Verletzungen im Kindesalter." Doctoral thesis, Universitätsbibliothek Leipzig, 2011. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-63800.
Повний текст джерелаPerera, Natascha. "Investigation of the biochemistry and function of neutrophil serine protease 4 (NSP4)." Diss., Ludwig-Maximilians-Universität München, 2014. http://nbn-resolving.de/urn:nbn:de:bvb:19-167536.
Повний текст джерелаDie Granula-assoziierten Serinproteasen der Neutrophilen, genannt Neutrophilen-Elastase, Cathepsin G (CG) und Proteinase 3, werden bereits seit über 30 Jahren intensiv erforscht. Sie sind hauptsächlich für ihre Funktion bei der intrazellulären Degradation von pathogenen Keimen bekannt. Außerdem werden sie zunehmend als wichtige Regulatoren der angeborenen Immunantwort angesehen. Im Jahr 2009 identifizierte ich eine vierte Serinprotease in Neutrophilen, die bis dahin komplett übersehen wurde. Das Ziel dieser Arbeit war eine ausführliche Untersuchung der Biochemie und Funktion dieser neuen Serinprotease 4 (NSP4) in humanen Neutrophilen. NSP4 konnte in immunhistochemischen Analysen normaler Gewebe nur in Neutrophilen und deren Vorläuferzellen im Knochenmark nachgewiesen werden. Die Menge von NSP4 im Gesamtzelllysat von Neutrophilen war 20-fach geringer als die von CG. Dennoch konnte ich nachweisen, dass NSP4 von aktivierten Neutrophilen sezerniert wird. In subzellulären Neutrophilen-Fraktionen war NSP4 in erster Linie mit azurophilen Granula assoziiert. Die Produktion und Ausbeute rekombinanter, aktiver NSP4 wurde mithilfe verschiedener DNA-Konstrukte und Expressionssysteme deutlich verbessert. Für die Bestimmung der proteolytischen Spezifität wurden E. coli Peptidbibliotheken, Massenspektrometrie und synthetische Peptidbibliotheken eingesetzt. Alle Ergebnisse ergaben eindeutig eine Arginin-Spezifität für NSP4. NSP4 wurde sehr gut von Heparin-Antithrombin, C1 Inhibitor und mit geringerer Effizienz von α1-Proteinase-Inhibitor (α1PI) blockiert. Die Ergebnisse ermöglichten die Herstellung einer NSP4-spezifischen α1PI Variante, die nachweislich mit der gesamten NSP4 aus Neutrophilen-Zelllysat und aus Überständen aktivierter Neutrophilen einen kovalenten Komplex bildete. Dies war ein klarer Hinweis für die Speicherung und Sekretion der NSP4 als aktive Endoprotease. Außerdem konnte ich zeigen, dass NSP4 in vivo von Dipeptidylpeptidase I (DPPI) aktiviert wird, da in einem Papillon-Lefèvre Patienten ohne funktionelle DPPI auch NSP4 nicht nachweisbar war. Intrazelluläre Kalziummessungen in HaCaT-Zellen ergaben, dass der Proteinase-aktivierte Rezeptor-2 ein mögliches natürliches Substrat für NSP4 sein könnte. In einer Pathogen-freien Reinraumumgebung zeigten NSP4-defiziente Mäuse bislang noch keinen Phänotyp. Auch die Aktivierung isolierter Neutrophilen durch Phorbolester oder Immunkomplexe war nicht beeinträchtigt. In dieser Arbeit gelang es mir, die erste aktive Arginin-spezifische Serinprotease (NSP4) in azurophilen Granula von Neutrophilen zu identifizieren. Wegen ihres Vorkommens in allen sequenzierten Genomen höherer Vertebraten könnte NSP4 eine wichtige Rolle bei der Steuerung und Verstärkung Neutrophilen-abhängiger Immunantworten zukommen.
Бурий, С. О., та Юрій Михайлович Краснопольський. "Удосконалення біотехнології процесу виробництва вакцини для профілактики ротавірусної інфекції". Thesis, Національний університет біоресурсів і природокористування України, 2019. http://repository.kpi.kharkov.ua/handle/KhPI-Press/44498.
Повний текст джерелаБурий, С. О., Юрій Михайлович Краснопольський та Олександр Миколайович Огурцов. "Удосконалення біотехнології процесу виробництва вакцини для профілактики ротавірусної інфекції". Thesis, Національний технічний університет "Харківський політехнічний інститут", 2019. http://repository.kpi.kharkov.ua/handle/KhPI-Press/44316.
Повний текст джерелаFisher, Christine Marie. "Perceptions of Elementary School Children`s Parents Regarding Sexuality Education." University of Toledo / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1404314459.
Повний текст джерелаJin, Yi. "Characterisation of the African horse sickness virus NS4 protein." Thesis, University of Glasgow, 2018. http://theses.gla.ac.uk/8973/.
Повний текст джерелаCortavarria, Erick, Francisco González, Akira Mejía, and Alberto Romani. "Lanzamiento de alimento para bebés dirigido al NSE C "Sanitos"." Universidad Peruana de Ciencias Aplicadas - UPC. Escuela de Postgrado, 2009. http://hdl.handle.net/10757/273874.
Повний текст джерелаBlanchi, Véronique. "Interet diagnostique de l'enolase neuron-specifique (nse) en pathologie pleuropulmonaire." Nice, 1988. http://www.theses.fr/1988NICE6510.
Повний текст джерелаStorey, Stephen Michael. "Intracellular trafficking and plasma membrane microdomain distribution of the NSP4 enterotoxin during rotavirus infection in epithelial cells." [College Station, Tex. : Texas A&M University, 2006. http://hdl.handle.net/1969.1/ETD-TAMU-1210.
Повний текст джерелаRodríguez, Díaz Jesús. "Estudios sobre la inmunogenicidad y los mecanismos fisiopatológicos de la proteína NSP4 de rotavirus." Doctoral thesis, Universitat de València, 2005. http://hdl.handle.net/10803/10106.
Повний текст джерелаThe baculovirus expression system in insect cells was utilized to produce and purify the biologically active form of the NSP4 protein from rotavirus strains isolated from different animal and human strains. After the immunization of mice with the different ourified NSP4 proteins the super-immune sera obtained from NSP4 immunized mice, strongly recognize the carboxi-end of the protein (aminoacids 114 to 175), being indicative of the immunodominance of this region.One of the objebtives of this thesis was to obtain monoclonal antibodies, using the phage display technique that showed to be a useful tool in producing antibodies that recognize different epitopes in the NSP4 protein, thus being able to conduct inhibitory studies to identify biological activity. One interesting result when using this technique was that the phage display technique allowed us for the isolation of single chain monoclonal antibodies against non-immunodominant regions of NSP4.We also present data on the immunogenicity of the NSP4 protein in natural rotavirus infections in humans. Our results show that the NSP4 protein elicits a humoral immune response in children that had been naturally infected by rotavirus. The IgG serical antibodies developed against the NSP4 in children suffering acute rotavirus gastroenteritis, present cross reactivity against more than one genotype of the protein in 40% of the studied cases, indicating that the recognition of A and B NSP4 genotypes is not always heterotypic.Finally we studied the possible role of the nitric oxide (NO) in rotavirus pathophysiology. The NSP4 protein produced an increase in NO secretion in cultured HT-29 human epithelial cells. This increase occurred in parallel to the intracellular calcium increase previously observed in the same cell line in response to the NSP4.The rotaviral infections in Blab/c mice produced an increase in the concentration of the nitric oxide derived products in the urine of the infected animals, through the induction of the inducible nitric oxide enzyme (iNOS) in the murine model. This increase was also observed in the urine of children suffering acute rotaviral gastroenteritis.
Kalluri, Anila. "EXPRESSION OF CHOLERA TOXIN B SUBUNIT-ROTAVIRUS NSP4 ENTEROTOXIN FUSION PROTEIN IN TRANSGENIC CHLOROPLASTS." Master's thesis, University of Central Florida, 2005. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/3069.
Повний текст джерелаM.S.
Department of Molecular Biology and Microbiology
Burnett College of Biomedical Sciences
Molecular Biology and Microbiology
TAVARES, Talissa de Moraes. "Caracterização dos genes de NSP4 e VP6 de amostras de rotavírus do grupo A provenientes de crianças da região Centro-Oeste do Brasil." Universidade Federal de Goiás, 2008. http://repositorio.bc.ufg.br/tede/handle/tde/1579.
Повний текст джерелаGroup A rotaviruses are the major cause of gastroenteritis in children throughout the world. Epidemiological surveys and molecular analysis of rotavirus strains are required for gastroenteritis control and prevention. Studies using VP6, an important immunogenic structural protein, and NSP4, a transmembrane nonstructural glycoprotein which is critical to rotavirus morphogenesis and pathogenesis, have been performed. In this study, 330 rotavirus-positive fecal samples previously obtained from children with or without diarrhea, between 1987 and 2003, in three cities of Central West Region of Brazil (Goiânia, Brasília and Campo Grande), were characterized for VP6- and NSP4-encoding genes. The VP6 and NSP4 genes were amplified by reverse transcription- polymerase chain reaction followed by sequencing and phylogenetic analysis. Detection rates of 84.8% and 78.5% were observed for VP6 and NSP4 genes, respectively. Two distinct genotypes could be recognized for NSP4 (A and B). It was observed that the G9P[6] samples were associated with genotype A, whereas the G1P[6], G1P[8], G2P[8], G3P[8], G4P[8] and G9P[8] samples were associated with genotype B. The analysis of VP6 gene allowed genogrouping of samples in two clusters, genogroups I and II. The G2P[4], G3P[4] and G9P[6] samples were identified as genogroup I, whereas the G1P[6], G1P[8], G2P[8], G4P[6], G4P[8] and G9P[8] samples were identified as genogroup II. In addition, it was showed that samples identified as VP6 genogroup I were associated with NSP4 genotype A and samples identified as VP6 genogroup II were associated with NSP4 genotype B. This investigation described different genetic groups representing diversity of group A rotavirus samples circulating in the Central West Region of Brazil.
Os rotavírus do grupo A são considerados como os principais agentes de gastroenterite em crianças em todo o mundo. Investigações de vigilância epidemiológica e molecular são importantes para o controle e prevenção da doença. Nesse sentido, destacam-se os estudos utilizando VP6, proteína estrutural que se tem mostrado como a mais imunogênica, e NSP4, uma glicoproteína não estrutural transmembrana envolvida na morfogênese e patogênese viral. No presente estudo, 330 amostras de rotavírus coletadas de 1987 a 2003, provenientes de espécimes fecais de crianças com ou sem diarréia, em três cidades da Região Centro-Oeste do Brasil (Goiânia, Brasília e Campo Grande), foram caracterizadas em relação aos genes que codificam as proteínas VP6 e NSP4. Inicialmente, foi feita a amplificação dos genes de VP6 e NSP4 pela reação em cadeia pela polimerase pós-transcrição reversa, seguida do seqüenciamento genômico e de análise filogenética. Os genes de VP6 e NSP4 foram detectados em 84,8% e 78,5% das amostras, respectivamente. Dois genótipos de NSP4 foram identificados (A e B). Foi observado que as amostras G9P[6] associaram-se ao genótipo A e as amostras G1P[6], G1P[8], G2P[8], G3P[8], G4P[8] e G9P[8] associaram-se ao genótipo B. A análise do gene VP6 permitiu a identificação de dois genogrupos distintos (I e II). As amostras G2P[4], G3P[4] e G9P[6] foram caracterizadas como genogrupo I, enquanto as amostras G1P[6], G1P[8], G2P[8], G4P[6], G4P[8] e G9P[8] foram caracterizadas como genogrupo II. Ainda foi evidenciado que as amostras genogrupo I de VP6 estavam associadas com genótipo A de NSP4, e as amostras genogrupo II de VP6 estavam associadas com genótipo B de NSP4. A presente investigação identificou diferentes variantes genéticas, mostrando a diversidade dos rotavírus do grupo A circulantes na Região Centro-Oeste do Brasil.
BARJAUD, PASCAL. "Etude d'un protocole d'utilisation dans la determination de la nse et du rapport nse/nne pour le suivi des cancers anaplasiques a petites cellules du poumon." Clermont-Ferrand 1, 1992. http://www.theses.fr/1992CLF13051.
Повний текст джерелаGruber, Christine. "Differentialdiagnose beim Lungenkarzinom durch CEA, CYFRA 21-1, NSE und ProGRP." Diss., lmu, 2008. http://nbn-resolving.de/urn:nbn:de:bvb:19-90260.
Повний текст джерелаFontenoy, Claudia, Maria Ines Ortiz, and Julio Santillana. "Relanzamiento y consolidación de la marca Trois en el NSE A." Master's thesis, Universidad Peruana de Ciencias Aplicadas (UPC), 2016. http://hdl.handle.net/10757/596581.
Повний текст джерелаZboril, Sabrina. "Diagnóstico da síndrome da disfunção cognitiva em cães idosos após procedimento cirúrgico-anestésico." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/10/10137/tde-16092015-112158/.
Повний текст джерелаCognitive dysfunction is defined as changes in mental processes and it detection is performed with the aid of neuropsychological tests. Recently research has been conducted in attempt to establish early neuro biochemicals markers to estimate neuronal death. This study evaluated 24 dogs that were distributed into two groups: CG - control group (up to 8 years old) (n = 10) and EG - elderly group (over 8 years) (n = 14). All animals underwent periodontal treatment under general anesthesia and were previously evaluated to detect the presence of systemic diseases. A complete neurological and cardiac examination were performed in all animals and also a peripheral venous blood samples were collected for blood count, kidney and liver profile. The animals were assessed for cognition by using two neuropsychological scales (ARCAD and CCDR) and the assessment of serum levels of protein markers of neuronal damage (NSE and S100β) pre and postoperatively. A significant increase in S100β protein in EG compared to the CG (p = 0.014) in the preoperative period was observerd and also between the post-extubation times in the animals of CG (p = 0.04). Through behavioral scales used it was not possible to detect cognitive dysfunction in the postoperative elderly dogs underwent surgical - anesthetic procedure. The values of S100β protein suggest that elderly animals may have preoperative neuroinflammation caused by systemic or central inflammation; however we could not correlate with the behavioral scales
Sarras, Marcella. "Påverkan av hemolys vid analys av neuronspecifikt enolas på Cobas." Thesis, Malmö universitet, Fakulteten för hälsa och samhälle (HS), 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-44406.
Повний текст джерелаNeuron Specific Enolase (NSE) is an important biomarker for diagnosing e.g. neuroendocrine tumors, especially small cell lung cancer (SCLC) and neuroblastoma. NSE is also used as a part of the investigation of brain damage in cardiac arrest. Because NSE is present in high concentrations in erythrocytes, hemolysis in the blood sample can cause falsely elevated NSE levels in serum without brain damage. The purpose of this study was to evaluate how hemolysis affects NSE analysis on Cobas, a fully automated analytical instrument. Measurement of NSE concentration was performed on Cobas 8000 from Roche Elecsys, based on immunochemical sandwich method with ElectroChemi-Luminescence Immunoassay (ECLI) detection technique. To study the effect of hemolysis, hemolysates were prepared from 20 patient samples. These hemolysates were added to pooled serum, with NSE levels within the reference range (<17 μg/L). The degree of hemolysis was also determined on Cobas 8000. The result showed a linear relationship between the measured hemolysis index (HI) values and S-NSE values. The variation in NSE contribution at the individual level was examined with the result that each hemolysis unit corresponds to an NSE contribution of 0.33 ± 0.07 µg/L, which is released from erythrocytes. A suggestion to solve the problem of hemolysis relating to NSE analysis is to use a compensatory factor to correct the NSE concentration. Compensation can be performed by using the relationship obtained in the study (1 HI = 0.33 ± 0.07 µg/L NSE contribution) and subtracting the contribution from the measured NSE concentration.
Small, Lauren. "An investigation into the function of the SUMOylation of Nse2 and PCNA in S. pombe." Thesis, University of Sussex, 2014. http://sro.sussex.ac.uk/id/eprint/52751/.
Повний текст джерелаRomero, Meza Verónica Patricia. "Sensibilidad materna y problemas de conducta en niños preescolares de NSE bajo." Bachelor's thesis, Pontificia Universidad Católica del Perú, 2016. http://tesis.pucp.edu.pe/repositorio/handle/123456789/7481.
Повний текст джерелаAinsworth and Bowlby raised that maternal sensitivity is a factor associated with the development of a secure attachment in the child, has been supported by several studies over time. In this way, the child, with a secure attachment, would be less likely to develop behavioral problems throughout his life. The present study aims to explore the relationship between maternal sensitivity and behavior problems in preschool children of low socioeconomic status belonging to Lima Metropolitana. In order to achieve this, 36 children with ages in a range of 36 to 59 months (M = 44.31 , SD = 7.09) were evaluated, as well as their mothers, whose age oscillated between 22 and 42 years (M = 28.33 , SD = 5.14). Also, to evaluate maternal sensitivity was used the Maternal Behavior for Preschooler´s Q-set (MBPQS) (Posada, Kaloustian, Richmond & Moreno, 2007) and for behavior problems the Child Behavior Check List 1.5- 5 (CBCL 1.5- 5) (Rescorla, 2005; ASEBA, 2014). The results show there were not significant relation between maternal sensitivity and behavior problems in the child. Likewise, we found one significant difference in global behavior problems in relation to the sex of the child, where boys tend to have greater problems of conduct than girls. Moreover, the externalizing scale was shown that boys are more likely to develop this kind of problems than girls, showing no significant difference in internalizing scale.
Tesis
Toledo, Flavia Dutra de. "Biomarcadores de lesão cerebral em pacientes idosos submetidos à anestesia subaracnoidea para tratamento de fraturas de fêmur." Universidade Estadual Paulista (UNESP), 2018. http://hdl.handle.net/11449/157335.
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Introdução: A última atualização demográfica do Instituto Brasileiro de Geografia e Estatística realizada em 2017 mostrou que a população acima de 60 anos representava 14,6% dos 207,1 milhões de habitantes do Brasil, o que corresponde a aproximadamente 30 milhões de idosos, com expectativa de vida de 75,8 anos. Entre 2007 e 2011, o número acumulado de internações por fraturas de fêmur em pacientes acima de 60 anos, nos hospitais do Sistema Único de Saúde, foi de 175.781 O delirium pós-operatório é uma complicação comum nos pacientes idosos, e está associado a hospitalizações prolongadas, maiores taxas de institucionalização após a alta, deterioração cognitiva prolongada, diminuição da capacidade funcional, além de ser fator independente de mortalidade em 6-12 meses. Estudo disponível na literatura mostra que 14 a 24% dos pacientes idosos com fratura de quadril apresentam delirium já na admissão hospitalar, sendo que a prevalência durante a internação chega a 56%. Os mecanismos fisiopatológicos do desenvolvimento do delirium pós-operatório (DPO) e do déficit cognitivo pós-operatório têm sido estudados em nível molecular, porém ainda com pouco ganho. Maiores esforços de pesquisa são colocados na identificação de biomarcadores diagnósticos e prognósticos que estejam relacionados com mecanismos moleculares que levam ao DPO. Objetivos: Primariamente, relacionar os níveis séricos de dois biomarcadores de neuroinflamação (S100B e enolase neurônio-específica) com a ocorrência de delirium pré e pós-operatório em pacientes idosos submetidos a cirurgias de correção de fratura de quadril (fêmur proximal). Como objetivo secundário, foi proposto avaliar a influência dos fatores sexo, hipotensão perioperatória, classificação de risco anestésico ASA, uso de fármacos anestésicos para sedação (midazolam e fentanil), além de duração e tipo de cirurgia realizada (artroplastia de quadril ou osteossíntese de fêmur) sobre os níveis dos biomarcadores. Métodos: Foi realizado estudo clínico observacional prospectivo com pacientes acima de 60 anos internados no HCFMB para correção de fratura de quadril (terço proximal do fêmur) no período de maio de 2017 a abril de 2018; todos os pacientes assinaram o Termo de Consentimento Livre e Esclarecido. Os pacientes foram avaliados em dois momentos: dentro das 24 horas que antecederam a cirurgia (M1) e, novamente, 24 horas após o final da cirurgia (M2). Em cada momento, foi realizado o diagnóstico de presença ou ausência de delirium por meio da escala CAM (Confusion Assessment Method), instrumento validado em Português, e foram coletadas amostras de sangue para dosagem de S100B e Enolase plasmáticos. As dosagens dos biomarcadores foram realizadas por método ELISA. Resultados: Dos 42 pacientes analisados, 33 eram do sexo feminino e 9 do sexo masculino (78,57% e 21,4%, respectivamente), com idade média de 71,97 ± 8,68 anos. Delirium ocorreu em 11,9% dos pacientes em M1 e 16,7% em M2. Não houve variação dos níveis médios de S100B entre pacientes com e sem delirium, nem dentro do mesmo momento, quanto de um momento para outro (p=0,12). Os valores médios de NSE foram estatisticamente diferentes quando comparados os pacientes sem delirium pré-operatório e aqueles com delirium pós-operatório (p=0,002); entretanto, pacientes que não tiveram delirium em qualquer momento também apresentaram variação significante do marcador entre M1 e M2 (p=0,004). Ainda, pacientes com delirium pós-operatório tiveram níveis mais altos de NSE dosados em M2 (p=0,02). Mulheres apresentaram maiores níveis de S100B (p=0,03), enquanto as médias de NSE foram maiores entre homens (p=0,04). Não houve influência da classificação ASA tanto nos níveis de S100B quanto de NSE (p=0,67 e p=0,12, respectivamente). Níveis mais altos de S100B foram verificados em pacientes que apresentaram algum episódio de hipotensão perioperatória (p=0,035), porém não houve relação entre este último evento e a ocorrência de delirium pós-operatório (p=0,65). Quanto ao uso de sedação intraoperatória, doses maiores de midazolam foram administradas aos pacientes que não desenvolveram DPO (p=0,001), enquanto as doses de fentanil não diferiram entre pacientes com e sem DPO (p=0,21). Não houve relação entre o tipo de procedimento cirúrgico executado e duração média da cirurgia (p=0,89 e p=0,15, respectivamente) com a ocorrência de DPO. Conclusões: Não foi encontrada associação entres os níveis do marcador S100B e a presença de delirium em qualquer momento; entretanto, níveis pré-operatórios aumentados de NSE foram relacionados à ocorrência de delirium pós-operatório. Pacientes com episódios de hipotensão perioperatória apresentaram níveis mais altos de S100B na avaliação pós-operatória. São necessárias investigações futuras quanto ao nível de expressão destas proteínas por outros tecidos e se existem outras vias de sinalização celular ainda desconhecidas, para que assim possamos entender melhor o comportamento destes biomarcadores e a sua relação com a patogênese do delirium.
Background: According to the latest census from IBGE (Instituto Brasileiro de Geografia e Estatística), population over 60 years-old accounted for 14,3% of a total 204,9 million habitants in Brazil. From 2007 to 2011, 175.781 elder patients were admitted after a hip fracture in brazilian public hospitals. Post-operative delirium (POD) is an usual complication in the elderly and is associated to longer hospital stay, cognitive impairment, functional decline and increased 6-12 months mortality rate. Delirium rates between the elder population can be as high as 14 to 24% already at admission, being the prevalence as high as 56% during hospital stay. Pathophysiologic mechanisms of delirium have been studied at molecular level, but research efforts are still needed in order to develop sensitive and specific early markers for this condition, so that diagnosis and effective treatment would be readily given. Objectives: This research project aims to correlate two neuroinflamation biomarkers serum levels (S100B protein and Neuron Specific Enolase - NSE) and the incidence of pre and postoperative delirium in elderly patients undergoing hip fracture repair. Also, we intent to evaluate how gender, ASA Physical Status classification and perioperative hypotension may contribute to changes in the levels of these biomarkers. Methods: An observational prospective study was proposed envolving patients aged 60 or more who were admitted at Clinics Hospital of Botucatu Medical School (Botucatu, São Paulo, Brazil) for hip fracture repair, from May, 2017 to April, 2018. All patients signed the Informed Consent. The CAM (Confusion Assessment Method) short scale was used to assess the presence of delirium first at admission and again, 24 hours after surgery. Blood samples were also collected at two moments, by the patient’s admission to the operating room and then 24 hours after surgery, to assess NSE and S100B plasmatic levels. S100B and NSE levels were measured on the Synergy HT Biotec analyzer using ELISA technique (Elabscience ® kits). Results: Of 42 patients included, 33 were female and 9 male (78.57% vs 21.4%), with mean age of 71.97 ± SD 8.68 years). Delirium occurred in 11.9% of patients at M1 and 16.7% at M2. S100B mean levels did not significantly change between patients with and without delirium, neither at the same moment (p=0.95 and p=0.96, respectively) nor from M1 to M2 (p=0,12). NSE levels in delirious and non-delirious patients at M1 were elevated at M2 (p=0.04); however, higher NSE levels at M1 were significantly related to emergence of delirium at M2 (p=0.002). Moreover, despite of the fact that NSE levels increased at M2 in patients without delirium (p=0.004), delirious patients at M2 had significantly higher NSE levels (p=0.02). S100B levels were higher in female patients (p=0.03), whereas NSE was higher in male ones (p=0.04). Perioperative hypotension was linked to higher S100B levels at M2 (p=0.035), but not to postoperative delirium 9p=0,65). ASA classification had no influence on biomarkers levels. Regarding the use of intraoperative sedation, higher amounts of midazolam were administered to patients who did not further develop POD (p=0.001); fentanyl doses did not differ between patients with or without POD (p=0.21). Surgical technique (hip replacement or osteosynthesis) and surgery duration had no influence on POD occurrence (p=0.89 and p=0.15, respectively). Conclusions: No association was found between S100B levels and delirium, but increased preoperative NSE levels were related to emergence of postoperative delirium. Patients with records showing episodes of perioperative hypotension had higher postoperative levels of S100B. Further investigation of yet unidentified tissue expression and signaling pathways of these proteins are needed in order for them to be used as predictors of delirium in clinical practice.
Skilton, Andrew Michael. "Investigation of SUMO phosphorylation and analysis of selected targets of the two sumo ligases NSE2 and PLI1." Thesis, University of Sussex, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.496854.
Повний текст джерелаPerera, Natascha [Verfasser], and Elisabeth [Akademischer Betreuer] Weiß. "Investigation of the biochemistry and function of neutrophil serine protease 4 (NSP4) / Natascha Perera. Betreuer: Elisabeth Weiß." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2014. http://d-nb.info/1049393120/34.
Повний текст джерелаApostolova, Sonia. "The RING domain of Nse1: roles in Smc5/6 complex stability and genome integrity in human cells." Doctoral thesis, Universitat de Lleida, 2021. http://hdl.handle.net/10803/672395.
Повний текст джерелаEl complejo Smc5/6, es uno de los tres complejos de mantenimiento de la estructura de los cromosomas (Structural Maintenance of Chromosomes, SMC). En esta tesis se muestra que el dominio RING de la subunidad Nse1 del complejo Smc5/6, tiene un papel crucial en el mantenimiento de la estabilidad genómica en células humanas. Mediante CRISPR-Cas9 hemos creado mutantes estables de NSE1 en el dominio RING C-terminal, en células HEK293T. En estos mutantes no se detecta la proteína Nse1, ni otras subunidades del complejo. Además, presentan un fenotipo de inestabilidad genómica, caracterizado por un crecimiento lento, mitosis más prolongadas, daño endógeno en el ADN, ralentización en la progresión de las horquillas de replicación y sensibilidad a el agente genotóxico MMS. Estos resultados sugieren que los mutantes en NSE1 entran en mitosis con la presencia de zonas del DNA no replicadas o con estructuras de recombinación no resueltas, que llevan a la rotura de cromosomas y a inestabilidad genómica en la siguiente generación.
The Smc5/6 complex is one of the three Structural Maintenance of Chromosomes (SMC) complexes. This thesis shows that the RING domain of the Nse1 subunit of the Smc5/6 complex plays a crucial role in maintaining genomic stability in human cells. Using CRISPR-Cas9 we created stable mutants of NSE1 in the C-terminal RING domain, in HEK293T cells. Nse1 protein and other subunits of the complex are not detected in these mutants. In addition, they present a phenotype of genomic instability, characterized by slow growth, prolonged mitosis, endogenous DNA damage, slowing in the progression of replication forks and sensitivity to the genotoxic agent MMS. These results suggest that mutants in NSE1 enter mitosis with the presence of unreplicated DNA regions or with unresolved recombination structures, leading to chromosome breakage and genomic instability, in the next generation.
Perera, Natascha Cynthia [Verfasser], and Elisabeth [Akademischer Betreuer] Weiß. "Investigation of the biochemistry and function of neutrophil serine protease 4 (NSP4) / Natascha Perera. Betreuer: Elisabeth Weiß." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2014. http://nbn-resolving.de/urn:nbn:de:bvb:19-167536.
Повний текст джерелаZhang, Zhihan. "NSEA: n-Node Subnetwork Enumeration Algorithm Identifies Lower Grade Glioma Subtypes with Altered Subnetworks and Distinct Prognostics." Case Western Reserve University School of Graduate Studies / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=case148595901371196.
Повний текст джерелаStoll, Alexander. "Neurologische Komplikationen nach Herzoperationen unter der Berücksichtigung der Hypoxiemarker NSE und Protein S100 /." Hamburg : Akademos Wiss.-Verl, 2003. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=010456703&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.
Повний текст джерелаSantAnna, Alexandre Magno de Souza. "Efeito da hidrogenação em solução NS4 nas propriedades do aço API 5L X-65." Universidade do Estado do Rio de Janeiro, 2010. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=1287.
Повний текст джерелаThe behavior of API 5L X-65 steel immersed in synthetic solution NS4 was studied. The changes caused on the effect of the hydrogen when applying a cathodic electrical potential on tensile and impact samples were also studied. The samples were immersed into saturate solution of copper sulfate to avoid the hydrogen desorption and after that, were performed tensile and impact tests. Some samples were submitted to shot peening process before suffering the hydrogen action. After these treatments the residual stress was determined by X ray tensometry. Additionally, cathodic and anodic polarization curves were obtained in NS4 solution deaerated with nitrogen gas. Moreover, the chemical balance of NS4 solution was performed. The fracture surfaces of the samples were analyzed using scanning electron microscopy.
Alfaro, Prieto Gladys Consuelo. "Sensibilidad materna y apoyo social percibido en madres de niños preescolares de NSE bajo." Bachelor's thesis, Pontificia Universidad Católica del Perú, 2017. http://tesis.pucp.edu.pe/repositorio/handle/123456789/9386.
Повний текст джерелаThe research aims at exploring the relationship between maternal sensitivity and perceived social support in mothers of pre-school children of low socioeconomic status. Twenty-nine mothers between the ages of 23 and 44 (M = 29.57, SD = 5.65), whose children were between 49 and 73 months of age (M = 57, SD = 6.87). This study used the Maternal Behavior for Preschoolers' Q-Set (Posada, Moreno, & Richmond, 1998) in observation mode, and the Social Support Medical Outcomes Questionnaire (Sherbourne & Stewart, 1991) validated in Spanish by Rodríguez and Enrique (2007). The results showed a significant and positive association of medium magnitude between instrumental type social support and the overall level of maternal sensitivity, as well as with the scale supervision and monitoring and safe base support. A specific objective was to describe maternal sensitivity, which was found a low level in her grades, as well as a negative correlation of marginal significance with the mother's age. Regarding the second specific objective, the social support was described and it was identified that the instrumental support is the one that is perceived in a smaller proportion than the other types of support, besides finding differences in the level of support according to the family structure of the mother. These findings indicate that in contexts of poverty, as mothers perceive behavioral and material assistance in the care of their preschool child and in their daily tasks, they tend to be more sensitive in parenting.
Tesis
Quantin, Xavier. "Intérêt pronostic de la NSE sérique pour le cancer bronchique non à petites cellules." Montpellier 1, 1995. http://www.theses.fr/1995MON11020.
Повний текст джерелаZwart, Lizahn. "Investigating two AHSV non-structural proteins : tubule-forming protein NS1 and novel protein NS4." Diss., University of Pretoria, 2013. http://hdl.handle.net/2263/62198.
Повний текст джерелаDissertation (MSc)--University of Pretoria, 2013.
Genetics
MSc
Unrestricted
Elias, Bruno Cesar. "Comparação dos valores séricos de enolase neuronal específica (NSE) em cães com e sem encefalite." Universidade Estadual de Londrina. Centro de Ciências Agrárias. Programa de Pós-Graduação em Ciência Animal, 2016. http://www.bibliotecadigital.uel.br/document/?code=vtls000205310.
Повний текст джерелаThe use of biomarkers in human and veterinary medicine is important to help the clinical management. Regarding to this, the specific neuronal enolase (NSE) is a biomarker resultant of the neuronal cell lysis, which demonstrate stability in extracellular fluids such as blood and cerebrospinal fluid. In human clinical researchs, was observed reliability in serum samples to distinguish and estimate the central nervous system damage in cases of encephalitis. In veterinary medicine, there are no studies evaluating the expression of NSE in serum samples from dogs with encephalitis. Thus, the objectives of this study was to compare the values of serum NSE in healty dogs and dogs with encephalitis and to evaluate theefficacy of the ELISA test using human antibodies in the detection of biomarker. For this, we used 38 dogs in total, divided into two groups, 19 dogs with encephalitis (GE) and 19 dogs without encephalitis (GS). The criteria for inclusion in to the GS were aged 1 to 7 years, with normal clinical and laboratory tests. For the GE inclusion, criteria were dogs with neurological signs brain injury, positive molecular diagnosis for distemper, and no signs of hemolysis. Regarding the results obtained it was found that for the GE serum NSE values higher with greater variation, and higher mean and median GS, there was a significant difference between the groups (p = 0.0053). In the serum samples tested, the NSE was effectivelly measured, demonstrating the feasibility of ELISA ?using human antibodies. Conclusions: in dogs with encephalitis the NSE values werer higher when compared to dogs without encephalitis, presenting a significant difference between the groups and contributing to the validation of serum NSE as a biomarker; the ELISA test can be used to measure the NSE in serum samples of dogs.
Neri, Pierre. "Use of GNSS signals and their augmentations for Civil Aviation navigation during Approaches with Vertical Guidance and Precision Approaches." Thesis, Toulouse, INPT, 2011. http://www.theses.fr/2011INPT0073/document.
Повний текст джерелаSince many years, civil aviation has identified GNSS as an attractive mean to provide navigation services for every phase of flight due to its wide coverage area. However, to do so, GNSS has to meet relevant requirements in terms of accuracy, integrity, availability and continuity. To achieve this performance, augmentation systems have been developed to correct the GNSS signals and to monitor the quality of the received Signal-In-Space (SIS). We can distinguish GBAS (Ground Based Augmentation Systems), ABAS (Airborne Based Augmentation Systems) SBAS (Satellite Based Augmentation Systems). In this context, the aim of this study is to characterize and evaluate the GNSS position error of various positioning solutions which may fulfil applicable civil aviation requirements for GNSS approaches. In particular, this study focuses on two particular solutions which are: • Combined GPS/GALILEO receivers augmented by RAIM where RAIM is a type of ABAS augmentation. This solution is a candidate to provide a mean to conduct approaches with vertical guidance (APV I, APV II and LPV 200). • GPS L1 C/A receivers augmented by GBAS. This solution should allow to conduct precision approaches down to CAT II/III, thus providing an alternative to classical radio navigation solutions such as ILS. This study deals with the characterization of the statistics of the position error at the output of these GNSS receivers. It is organised as following. First a review of civil aviation requirements is presented. Then, the different GNSS signals structure and the associated signal processing selected are described. We only considered GPS and GALILEO constellations and concentrated on signals suitable for civil aviation receivers. The next section details the GNSS measurement models used to model the measurements made by civil aviation receivers using the previous GNSS signals. The following chapter presents the GPS/GALILEO and RAIM combination model developed as well as our conclusions on the statistics of the resulting position error. The last part depicts the GBAS NSE (Navigation System Error) model proposed in this report as well as the rationales for this model
Yildirim, Gokce. "Smoke Simulation On Programmable Graphics Hardware." Master's thesis, METU, 2005. http://etd.lib.metu.edu.tr/upload/12606545/index.pdf.
Повний текст джерелаPozo, Romero Jaime Augusto del. "Plan de Negocios: Livian: “Yogurt Probiótico Natural con Frutas para el NSE “B” de Lima Metropolitana"." Tesis, Universidad de Chile, 2010. http://www.repositorio.uchile.cl/handle/2250/102278.
Повний текст джерелаWiener, Carolina David. "Níveis séricos de ácido úrico e as atividades a superóxido dismutase e da catalase nos transtornos de humor." Universidade Catolica de Pelotas, 2013. http://tede.ucpel.edu.br:8080/jspui/handle/tede/517.
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Objectives: The aim of this study was evaluate uric acid level in a population–based sample of young adults (18 to 24 years old). People with bipolar and depression disorder were compared with healthy psychiatric subjects without a history of mood episodes. Methods: Case-control study nested in a population-based sample. The diagnosis was confirmed with the Structured Clinical Interview for DSM-IV. The uric acid was assessed by commercial kits Results: The sample consisted of 216 subjects, 49 with diagnosis for bipolar disorder, 76 with depression and 91 population control. The uric acid levels were similar (control = 4.08 ± 1.27 mg/dL, depression = 3.78 ± 1.00 mg/dL e bipolar disorder =3.86 ± 1.33 mg/dL, p= 0,251). For maniac/hippomaniac and depressive episodes, were observed a tendency to increase in acid uric levels in maniac/hippomaniac episodes (4.43 ± 1.74 mg/dL) and a decrease in depressive episodes (3.70 ± 0.99 mg/dL) when compared to control subjects (4.08 ± 1.27 mg/dL)(p= 0.106). Conclusion: Uric acid levels is not correlated with diagnosis group, but the uric acid level have a tendency to presented increased in manic and/ or mixed episodes and decreased in depression episode, these result observed that levels of uric acid in mood disorders are altered according to the manifestation of symptoms.
Objetivo: O objetivo deste estudo é avaliar o nível de acido úrico em pacientes com transtornos de humor oriundo de uma amostra de base populacional com jovens adultos (18 a 24 anos), para este fim jovens com transtorno de humor bipolar e depressão foram comparados com jovens sem histórico de transtorno de humor. Métodos: Trata-se de um estudo de caso-controle aninhado a um estudo de base populacional, o diagnostico foi realizado através da Entrevista Clínica Estruturada para o DSM-IV (SCID) e os níveis de acido úrico séricos foram dosados utilizando-se kits comerciais. Resultados: A amostra foi constituída de 216 jovens, 49 com diagnostico de transtorno bipolar, 76 com depressão e 91 controles sem historia psiquiátrica prévia, os níveis de acido úrico entre os três grupos foram similares (controle = 4.08 ± 1.27 mg/dL, depressão = 3.78 ± 1.00 mg/dL e transtorno bipolar =3.86 ± 1.33 mg/dL, p= 0,251). Quando avaliados os níveis de ácido úrico entre os episódios mania/hipomania e depressivo, observa-se uma tendência no aumento do ácido úrico no episódio maníaco/misto (4,43 ± 1,74 mg/dL) e uma diminuição no episódio depressivo (3,70 ± 0,99 mg/dL) quando comparados aos jovens do grupo controle (4,08 ± 1,27 mg/dL)(p= 0,106). Conclusão: Os níveis de ácido úrico não foram significativos entre os grupos diagnósticos, porém os níveis de acido úrico apresentaram uma tendência para o aumento nos episódios maníacos e/ou mistos e uma diminuição no episódio depressivo, com estes resultados podemos observar que os níveis de acido úrico nos transtornos de humor podem estar alterados de acordo com a manifestação dos sintomas
Torres, Andre L. "An inexpensive, plant-derived, dual vaccine for rotavirus and cholera." Honors in the Major Thesis, University of Central Florida, 2009. http://digital.library.ucf.edu/cdm/ref/collection/ETH/id/1333.
Повний текст джерелаBachelors
Medicine
Biotechnology
Outwin, Emily Anthea. "Investigation of SUMO phosphorylation and characterisation of the SUMO ligase NSE2, a member of the SMC5-6 complex, in fission yeast." Thesis, University of Sussex, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.418452.
Повний текст джерелаMeyer, Oliver Frank Peter. "Diagnostischer Wert der Serummarker S-100[beta] [S100Beta] und NSE für ein postoperatives kognitives Defizit nach Allgemeinnarkosen." [S.l.] : [s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=975023357.
Повний текст джерелаKrohn, Michael [Verfasser], Christoph [Gutachter] Müller, and Michael [Gutachter] Bernhard. "Immunhistochemische Untersuchungen mittels S100 und NSE nach Schädel-Hirn-Trauma / Michael Krohn ; Gutachter: Christoph Müller, Michael Bernhard." Leipzig : Universitätsbibliothek Leipzig, 2015. http://d-nb.info/1239740263/34.
Повний текст джерелаCoral, Chávez Evelyn Desiree. "Conducta de base segura y sensibilidad materna en diadas de NSE bajo, y la satisfacción con la pareja." Bachelor's thesis, Pontificia Universidad Católica del Perú, 2016. http://tesis.pucp.edu.pe/repositorio/handle/123456789/7083.
Повний текст джерелаThe current study aims to explore and describe the relationship between maternal sensitivity and child's secure base behavior and the relationship satisfaction in a group of mothers and children of a low socioeconomic status of a district of Lima Metropolitana. For this purpose, 27 mothers were evaluated aged between 21 and 38 years (M = 26.63, DE = 4.42) and their children, aged between 36 and 59 months (M = 43.37, DE = 6.72), using the Maternal Behavior for Preschoolers Q-set (MBPQS; Posada, Kaloustian, Jacobs, Richmond y Moreno, 1998) for maternal sensitivity, the Attachment Q-set (AQS) (Waters, 1995) for secure base behavior, and, the Relationship Assessment Scale (RAS; Hendrick, 1988) for relationship satisfaction. Significant differences were found between the behavior of the mothers and the theoretical criterion for the secure base behavior and for the maternal sensitivity, both variables being very low in contrast with the ideal mean. Also, a positive and significant relationship was found between both constructs. The Proximity-seeking to mother dimension of the AQS was related in a positive way with Contribution to Harmonious Interactions, Safe Base Support and Supervision of the MBPQS. Additionally, the scale Smooth interactions with mother was related in a direct way with Contribution to Harmonious Interactions and Setting limits scales of the MBPQS. On the other hand, the partial correlation analysis was used between secure base behavior and maternal sensitivity, controlling the relationship satisfaction effects and there was a positive and significant relation.
Tesis
Vallejo, Santa María Helí Jesús. "Diseño de un servicio de Internet para el hogar adecuado al segmento del mercado de NSE C/D." Bachelor's thesis, Universidad Peruana de Ciencias Aplicadas (UPC), 2013. http://hdl.handle.net/10757/273436.
Повний текст джерелаÁlvarez, Elías Ana Fabiola, Sandoval Maritza Benites, Gonzales Luis Enrique Flores, and Farfán Eugenia Mercedes Mont. "Plan de negocios de una empresa comercializadora de granos andinos para el segmento NSE C de Lima Metropolitana." Master's thesis, Universidad Peruana de Ciencias Aplicadas (UPC), 2021. http://hdl.handle.net/10757/656742.
Повний текст джерелаThis business plan seeks to evaluate the feasibility for the creation of a commercial company for conventional Andean grains, mainly quinoa, kiwicha, tarwi and cañihua, which will enter the market with the brand “Grandino”. So, the analysis of the macro and microenvironment was carried out to evaluate the conditions, the business opportunity and the attractive of the market. To better understand the consumer, a survey has been carried out, which allowed to conclude that there is willingness and interest in the consumption of Andean grains; and it facilitated the definition of various aspects related to the business model. As a competitive advantage, Grandino will offer products that meet current food needs, with the attributes of being nutritious and at the best price. For the launch, the actions will focus on generating knowledge and trust in our brand and products, and that our target audience verifies the quality / price factor of our offer. Grandino’s management seeks to be agile and modern, so the conditioning of the products, the transportation and the distribution will be outsourced, focusing on the commercial objectives for the positioning of the brand in the market of Lima City. In general, and after evaluating the demand and the operational, commercial, economic, and financial viability, it is a business opportunity with adequate profitability levels, which serves an expanding market, on which this initiative can start its activity.
Trabajo de investigación