Дисертації з теми "Novel Molecules"
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Walsh, Anthony. "Novel methods to access bioactive molecules." Thesis, University of Huddersfield, 2015. http://eprints.hud.ac.uk/id/eprint/26947/.
Повний текст джерелаOdenthal, Katherine Jane Chemistry Faculty of Science UNSW. "Novel redox molecules for surface electrochemistry." Publisher:University of New South Wales. Chemistry, 2009. http://handle.unsw.edu.au/1959.4/43661.
Повний текст джерелаStrelko, Cheryl. "Novel Small Molecules and Tumor Cells." Thesis, Boston College, 2012. http://hdl.handle.net/2345/3778.
Повний текст джерелаThesis advisor: Eranthie Weerapana
Small molecules are of interest both as metabolites in tumor cell biology and as potential therapeutics in the fight against cancer. In this work, small molecules in both roles have been examined. Modulation of tumor cell metabolism holds promise as a strategy to combat cancer, and both glucose and glutamine have been identified as critical fuels for tumor cell growth and proliferation. However, the reason for glutamine addiction is poorly understood. The differential metabolism of glutamine and glucose was therefore examined using ¹³C labeling and NMR-based metabolomics in the VM-M3 tumor cell line, which requires both glucose and glutamine for survival and proliferation. In the course of this study, a novel mammalian metabolite itaconic acid was identified. Itaconic acid was detected in extracts and tissue culture media from the murine macrophage-derived tumor cell lines VM-M3 and RAW 264.7 as well as in primary macrophages. Production and secretion of itaconic acid was increased upon stimulation. LC-MS and NMR based metabolomics studies show that this metabolite is synthesized by the decarboxylation of cis-aconitate from the TCA cycle, and provided evidence for a novel mammalian homologue of the enzyme cis-aconitic decarboxylase. D-3-deoxy diC₈PI is a small molecule of interest as a potential cancer therapeutic. This compound was designed to induce apoptosis in tumor cells by competitively binding to the Akt PH domain and preventing Akt translocation. However, high resolution ³¹P field-cycling studies show that both D-3-deoxy diC₈PI and an inactive analogue L-3,5-dideoxy diC₈PI bind to the same site on the PH domain, which is distinct from the binding site of the ligand diC₈PI(3,4,5)P₃. This makes the aforementioned mechanism of cytotoxicity unlikely. Aggregation of the PH domain in the presence of soluble headgroup IP₆ was also observed, which may be related to a physiological function of this protein and invalidates at least one other binding assay. Investigation into alterations in signaling pathways in the MCF-7 breast cancer cell line showed that D-3-deoxy diC₈PI activates the p38MAPK pathway which results in CREB hyperphosphorylation. However, activation of this pathway appears to be compensatory and unrelated to the mechanism of action. D-3-deoxy diC₈PI also decreases levels of cyclin D1 and cyclin D3, which regulate the progression of the cell cycle. These decreases appear to be occurring at the transcriptional level rather than due to increased proteasomal degradation. The loss of these two proteins does not cause apoptosis in MCF-7 cells, but siRNA knockdown of specifically cyclin D1 inhibits proliferation. This is consistent with the cell cycle arrest observed upon D-3-deoxy diC₈PI treatment in these cells. These findings do not conclusively elucidate the mechanism of cytotoxicity of D-3-deoxy diC₈PI, but provide a characterization of some of its effects in the MCF-7 cell line which may be useful for further studies
Thesis (PhD) — Boston College, 2012
Submitted to: Boston College. Graduate School of Arts and Sciences
Discipline: Chemistry
Adamson, R. D. "Novel methods for large molecules in quantum chemistry." Thesis, University of Cambridge, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.595361.
Повний текст джерелаSmith, Euan Christopher. "Ultrafast third-order nonlinearities in novel zwitterionic molecules." Thesis, Heriot-Watt University, 1998. http://hdl.handle.net/10399/599.
Повний текст джерелаDrayna, Garrett Korda. "Novel Applications of Buffer-Gas Cooling to Cold Atoms, Diatomic Molecules, and Large Molecules." Thesis, Harvard University, 2016. http://nrs.harvard.edu/urn-3:HUL.InstRepos:26718757.
Повний текст джерелаChemical Physics
Tetteh, Kevin Kwaku Adjei. "Molecular characterisation of novel functionally important molecules of the model parasitic nematode, Toxocara canis." Thesis, University of Edinburgh, 1999. http://hdl.handle.net/1842/11455.
Повний текст джерелаNeri, Tommaso. "Novel organic semiconducting small molecules for X-ray detection." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2017. http://amslaurea.unibo.it/14809/.
Повний текст джерелаShen, Dong. "Syntheses and mesophase characterizations of novel bent core molecules." [S.l. : s.n.], 2000. http://deposit.ddb.de/cgi-bin/dokserv?idn=961481889.
Повний текст джерелаDattani, Hema. "Novel Tripodal Receptors Designed to Recognize Anionic Guest Molecules." Thesis, University of Oxford, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.489428.
Повний текст джерелаFortuin, Elton E. "Novel aminoquinoline-polycyclic hybrid molecules as potential antimalarial agents." University of the Western Cape, 2014. http://hdl.handle.net/11394/4463.
Повний текст джерелаPlasmodium falciparum malaria continues to be a worldwide health problem, especially in developing countries in Africa and is responsible for over a million fatalities per annum. Chloroquine (CQ) is low-cost, safe and was the mainstay aminoquinoline derived chemotherapeutic agent that has been used for many years against blood-stage malaria. However, today the control of malaria has been complicated by increased resistance of the malaria parasite to existing antimalarial agents such as CQ. The primary cause of resistance is mutation in a putative ATP-powered multidrug efflux pump known as the p-glycoprotein (pGP) pump, and point mutation in P. falciparum CQ resistance transporter (PfCRT) protein. These mutations are responsible for the reduced accumulation of CQ at its primary site of action, the acidic digestive food vacuole of the parasite.To overcome the challenges of CQ resistance in P. falciparum, chemosensitiser offer an attractive approach. Chemosensitisers or reversal agents are structurally diverse molecules that are known to reverse CQ resistance by inhibiting the pGP efflux pump and/or the PfCRT protein associated with CQ export from the digestive vacuole in CQ resistant parasites. Chemosensitisers include the well-studied calcium channel blocker verapamil and antihistaminic agent chlorpheniramine. These drugs have little or no inherent antimalarial activity but have shown to reverse CQ resistance in P. falciparum when co-administered with CQ. Because of the channel blocking abilities of pentacycloundecylamines (PCUs) such as NGP1-01, it is postulated that these agents may act as chemosensitisers and circumvent the resistance of the Plasmodium parasite against CQ. Therefore as a proof of concept we conducted an experiment using CQ co- administered with different concentrations of NGP1-01 to evaluate the ability of NGP1-01 to act as a chemosensitiser.Herein, we report the ability of NGP1-01, the prototype pentacycloundecylamine (PCU), to reverse CQ resistance (> 50 %) and act as a chemosensitiser. NGP1-01 alone exhibited very low intrinsic antimalarial activity against both the resistant and sensitive strain (> 2000 nM), with no toxicity to the parasite detected at 10 µM. A statistically significant (p < 0.05) dose dependent shift was seen in the CQ IC50 values at both 1 µM and 10 µM concentration of co-administeredNGP1-01 against the resistant strain. Based on this finding we set out to synthesise a series of novel agents comprising of a PCU moiety as the reversal agent (RA) conjugated to a CQ-like aminoquinoline (AM) molecule and evaluate the potential of these PCU-AM derivatives as antimalarial- and/or reversed CQ agents. As recently shown by Peyton et al., (2012), the conjugation of a CQ-like molecule with a RA such as the chemosensitiser imipramine and derivatives thereof is a viable strategy to reverse CQ resistance in multidrug-resistant P. falciparum. The novel compounds were obtained by amination and reductive amination reactions. The synthetic procedures involved the conjugation of the Cookson’s diketone with different tethered 4-aminoquinoline moieties to yield the respective carbinolamines and the subsequent imines. This was followed by a transannular cyclisation using sodium cyanoborohydride as reducing agent to yield the desired PCU-AM derivatives. The CQ-like AMderivatives were obtained using a novel microwave (MW) irradiation method. Structure elucidation was done by utilising 1H- and 13C NMR spectroscopy as well as IR absorption spectrophotometry and mass spectrometry. Five PCU-AM reversed CQ derivatives were successfully synthesised and showed significant in vitro antimalarial activity against the CQ sensitive strain (NF54). PCU-AM derivatives 1.1 – 1.4 showed antimalarial IC50 values in the ranges of 3.74 – 17.6 ng/mL and 27.6 – 253.5 ng/mL against the CQ-sensitive (NF54) and CQ-resistant strains (Dd2) of Plasmodium falciparum, respectively. Compound 1.1 presented with the highest antimalarial activity against both strains and was found to be 5 fold more active against the resistant strain than CQ. The reversed CQ approach resulted in improved resistance reversal and a significantly lower concentration PCU was required compared to NGP1-01 and CQ in combination. This may be attributed to the improved ability of compound 1.1 to actively block the pGP pump and/or the increased permeability thereof because of the lipophilic aza-PCU moiety. Compound 1.1 also showed the lowest RMI value confirming that this compound has the best potential to act as a reversed CQ agent in the series. Cytotoxicity IC50 values observed for compounds 1.1 – 1.4 were in the low micromolar concentrations (2.39 – 9.54 µM) indicating selectivity towards P. falciparum (SI = 149 – 2549) and low toxicity compared to the cytotoxic agent emetine (IC50 = 0.061 µM).These results indicate that PCU channel blockers and PCU-AM derived conjugates can be utilised as lead molecules for further optimisation and development to enhance their therapeuticpotential as reversal agents and reversed CQ compounds.
Wheeler, Martyn David. "Two novel laser-based techniques for molecular spectroscopy." Thesis, University of Bristol, 1997. http://hdl.handle.net/1983/99fefda0-4274-4bb3-8f37-9506f028d011.
Повний текст джерелаMakha, Mohamed 1965. "Novel sulfonated extended arm calixarenes." Monash University, School of Chemistry, 2001. http://arrow.monash.edu.au/hdl/1959.1/8295.
Повний текст джерелаSheldon, Alexander. "A novel desymmetrisation approach towards chiral molecules, using 'click' chemistry." Thesis, University of East Anglia, 2016. https://ueaeprints.uea.ac.uk/59616/.
Повний текст джерелаEllis, Samantha. "Induction of the antigen presentation machinery using novel small molecules." Thesis, University of British Columbia, 2017. http://hdl.handle.net/2429/60473.
Повний текст джерелаTinarelli, Alessandro <1975>. "Novel Methodologies for the Synthesis of Scaffolds for Bioactive Molecules." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2010. http://amsdottorato.unibo.it/2291/.
Повний текст джерелаBateman, James. "Novel schemes for the optical manipulation of atoms and molecules." Thesis, University of Southampton, 2009. https://eprints.soton.ac.uk/66189/.
Повний текст джерелаRudge, James B. "An investigation into the synthesis of potentially chemiluminescent novel molecules." Thesis, Swansea University, 2004. https://cronfa.swan.ac.uk/Record/cronfa43129.
Повний текст джерелаLi, Mingxuan. "Self-Assemble of Novel Discotic Nano-Molecules Based on Polyhedraloligomericsilsesquioxanes." University of Akron / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=akron1399242960.
Повний текст джерелаMeyer, Amanda R. "Novel approaches for the chromatographic and electrophoretic separation of molecules." Diss., Manhattan, Kan. : Kansas State University, 2008. http://hdl.handle.net/2097/1031.
Повний текст джерелаMollentze, Theodorus Bernardus. "Rabies virus emergence in novel hosts : from molecules to landscapes." Thesis, University of Glasgow, 2018. http://theses.gla.ac.uk/8935/.
Повний текст джерелаWarrier, Thulasi. "Novel small molecules targeting Ag85C, mycolyl transferase of Mycobacterium tuberculosis." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2010. http://dx.doi.org/10.18452/16160.
Повний текст джерелаMycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB) infects about one-third of the world’s population. Therefore there is an urgent need to improve existing intervention strategies. This study evaluated the Mtb Ag85C protein, a mycolyl transferase, as a novel target for drug mediated intervention. Ag85C belongs to a family of three cognate proteins, Ag85A, B and C. They are involved in the final steps of Mtb cell envelope biogenesis. A panel of chemical molecules, Ag85C-1-4, which bind to Ag85C were utilized as inhibitors of Ag85C. All compounds inhibited growth of Mtb in vitro in liquid medium cultures but only Ag85C-3 had an effect on intracellular bacteria in macrophage infection system. Importantly, Ag85C-3 can inhibit in vitro survival of a MDR strain of Mtb making it a relevant molecule in the search for novel classes of anti-mycobacterial compounds. Furthermore a detailed functional characterization of Ag85C-3 effect on Mtb was performed. It modified the cell wall mycolic acid containing lipid amounts by blocking Ag85 function that led to changes in permeability of Mtb envelope. A comprehensive analysis of Mtb signalling pathways regulated by Ag85C-3 was investigated through microarray analysis. It showed modification of vital siderophore biosynthesis indicating multiple mechanisms of action. Thus the target, Ag85C and the inhibitor, Ag85C-3 are promising candidates for future TB drug research aimed at combating broad spectrum resistance development. This study also reinforces target based identification of chemical inhibitors as a valid and valuable approach in drug development.
Muneer, Saiqa. "Novel nanoformulations and nanosensors for bioactive molecules of biomedical significance." Thesis, Queensland University of Technology, 2021. https://eprints.qut.edu.au/213224/1/Saiqa_Muneer_Thesis.pdf.
Повний текст джерелаHermann, Keith R. "Novel Architectures in Cavitand Chemistry: Shaping Molecular Inner Space." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1406148569.
Повний текст джерелаChang, Yuan-Pin. "Novel probes of angular momentum polarization." Thesis, University of Oxford, 2010. http://ora.ox.ac.uk/objects/uuid:d3880edf-436a-415e-8a74-6b1c0fd26e65.
Повний текст джерелаTalló, Parra Marc 1992. "Circular RNAs : from host RNA molecules to novel broad-spectrum antivirals." Doctoral thesis, Universitat Pompeu Fabra, 2019. http://hdl.handle.net/10803/668309.
Повний текст джерелаThe clinical importance of the mosquito-borne viruses, such as dengue virus (DENV), zika virus (ZIKV) chikungunya virus (CHIKV) and West Nile virus (WNV), has dramatically increased over the last years, resulting in a global health problem. Currently, there are no available treatments or effective vaccines to treat these infections. All these viruses produce acute infections that require to be treated early after the onset of the symptoms for drugs to be effective. However, an early diagnosis remains still as an unsolved challenge. This brings to the spotlight the need to uncover novel fundamental virus-cell interactions that could be targeted and to develop efficient broad-spectrum antiviral therapies that could be administered before an accurate diagnosis is achieved. In this thesis we addressed these two major concerns with a focus in circular RNAs (circRNAs). CircRNAs are a class of RNAs generated from linear RNA progenitors by an alternative splicing mechanism termed back splicing. They are highly stable relative to their linear spliced counterparts due to exonuclease resistance. Currently, cellular circRNAs are described to be involved in viral infections. However, their precise role is mainly unknown. The first chapter of the thesis addresses this intriguing issue using HCV as a model system and analyzing the effect of the identified circRNAs in mosquito-borne viruses that belong to the same viral group. By RNA-Seq analyses we identified 73 HCV-differentially expressed circRNAs whose changes could not be explained by parallel changes in linear mRNAs. Silencing of five selected HCV-induced up-regulated circRNAs altered viral infectivity, acting either as anti-viral or pro-viral molecules. Further characterization of one of the selected circRNAs, cPSD3, show, that it also impaired DENV infections. The second chapter focuses on the generation of a novel circRNA-based platform that is versatile, hampers the emergence of resistant mutants, and allows developing broad-spectrum antivirals. In contrast to other RNA-based therapies, circRNAs are highly stable molecules, a trait that will simplify their therapeutic use. The designed synthetic circRNAs contain long sequences that hybridize to multiple target sequences in the viral RNA genome involved in forming RNA structures essential for virus survival. As a proof of concept, we have successfully validated circRNAs that inhibit HCV, DENV, CHIKV or WNV. Furthermore, we have generated circRNAs with broad-spectrum antiviral capacity and optimized the production in vitro of these molecules to obtain high amounts at low price. In conclusion, our results (i) emphasize the complexity of the interaction between cellular circRNAs and viruses and (ii) uncover the great potential of artificial circRNAs as novel platforms for drug development.
Tennant, Ian. "Antibody-based strategies for identifying novel apoptotic-cell surface-associated molecules." Thesis, University of Edinburgh, 2005. http://hdl.handle.net/1842/29395.
Повний текст джерелаTriana-Baltzer, Gallen B. "Nicotinic synapse formation between neurons novel roles for cell adhesion molecules /." Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2007. http://wwwlib.umi.com/cr/ucsd/fullcit?p3259623.
Повний текст джерелаTitle from first page of PDF file (viewed June 21, 2007). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references.
Cárdenas, Rafael. "Infrared studies on the spectra and structures of novel carbon molecules." Fort Worth, Tex. : Texas Christian University, 2007. http://etd.tcu.edu/etdfiles/available/etd-12062007-092327/unrestricted/Cardenas.pdf.
Повний текст джерелаHerrmann, Leonie. "Identification and characterization of novel candidate molecules for posttraumatic stress disorder." Diss., Ludwig-Maximilians-Universität München, 2012. http://nbn-resolving.de/urn:nbn:de:bvb:19-157327.
Повний текст джерелаBell, I. S. "Novel phosphorus-bearing transient molecules studied by infrared diode laser spectroscopy." Thesis, University of Cambridge, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.596544.
Повний текст джерелаAli, S. M. "Relaxation studies of various molecules using a novel modulated temperature technique." Thesis, University of Salford, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.353963.
Повний текст джерелаAndrews, Gracie L. "A novel role for cell adhesion molecules in nervous system development." abstract and full text PDF (free order & download UNR users only), 2008. http://0-gateway.proquest.com.innopac.library.unr.edu/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3307129.
Повний текст джерелаKarageorgis, George. "A novel evolutionary approach for the discovery of small bioactive molecules." Thesis, University of Leeds, 2015. http://etheses.whiterose.ac.uk/8343/.
Повний текст джерелаFoster, Michael Scott. "Design, synthesis, kinetic analysis, molecular modeling, and pharmacological evaluation of novel inhibitors of peptide amidation." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/31816.
Повний текст джерелаCommittee Chair: Dr. Sheldon W. May; Committee Member: Dr. James C. Powers; Committee Member: Dr. Nicholas Hud; Committee Member: Dr. Niren Murthy; Committee Member: Dr. Stanley H. Pollock. Part of the SMARTech Electronic Thesis and Dissertation Collection.
Jenkins, Jerry W. "Novel efficient simulation techniques for use in molecular modeling." Diss., Georgia Institute of Technology, 2000. http://hdl.handle.net/1853/11238.
Повний текст джерелаDhillon, Jatinder Kaur. "Novel antibody based molecules for detection of the microbial pathogen Yersinia pestis." Thesis, University of Aberdeen, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.416572.
Повний текст джерелаMoorthy, Ramkumar. "Novel Asymmetric Approaches for Construction of Small Molecules by Cyclization and Cycloaddition." Diss., North Dakota State University, 2015. http://hdl.handle.net/10365/25538.
Повний текст джерелаWeightman, John S. "Spectroscopic and electrochemical sensing of anions and cations using novel receptor molecules." Thesis, Loughborough University, 1996. https://dspace.lboro.ac.uk/2134/13771.
Повний текст джерелаLarcher, Leon Maria. "Development of novel oligonucleotide therapeutic molecules targeting microRNAs for tackling brain cancers." Thesis, Larcher, Leon Maria (2018) Development of novel oligonucleotide therapeutic molecules targeting microRNAs for tackling brain cancers. Honours thesis, Murdoch University, 2018. https://researchrepository.murdoch.edu.au/id/eprint/42397/.
Повний текст джерелаBubner, Timothy Paul. "Synthesis of novel sterically constrained aryl-alkyne type molecules for nonlinear optical studies /." Title page, table of contents and abstract only, 1996. http://web4.library.adelaide.edu.au/theses/09PH/09phb9173.pdf.
Повний текст джерелаRodgers, Mark Andrew. "Using non-immunoglobulin proteins to develop novel impedimetric biosensors for small hydrophobic molecules." Thesis, University of Leeds, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.522978.
Повний текст джерелаAl, Suleimani Yousuf Mohammed. "An investigation into the actions of novel lipid signalling molecules in the vasculature." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610210.
Повний текст джерелаEugster, Bickle Anne Caroline. "COP I domains required for coatomer integrity and novel interactions with regulatory molecules." Thesis, University of Cambridge, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.620984.
Повний текст джерелаCameron, Joseph. "Small molecules based on novel electron-deficient acceptor units for organic electronic applications." Thesis, University of Strathclyde, 2016. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=26932.
Повний текст джерелаAlqahtani, Hanan Dhafer S. "Studying the Mechanism of Ferroptosis Induced by a Novel Class of Small Molecules." University of Toledo / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1470398949.
Повний текст джерелаXiao, Li. "Synthetic Apratoxin F and Novel Analogues - Molecules for Anticancer Mechanistic and Therapeutic Applications." The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1512083096370725.
Повний текст джерелаMao, Yifan. "SYNTHESIS AND CHARACTERIZATION OF NOVEL p-CONJUGATED MOLECULES FOR ORGANIC REDOX-FLOW BATTERIES." University of Akron / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=akron1522333087480595.
Повний текст джерелаHassanain, Waleed A. "Novel nanoscale platforms for the isolation and ultra-trace detection of bioactive molecules." Thesis, Queensland University of Technology, 2019. https://eprints.qut.edu.au/124159/1/Waleed_Hassanain_Thesis.pdf.
Повний текст джерелаAl-Safadi, Sherin. "Mechanism of action of novel single arm alkylating "combi-molecules" and bi-functional "bis-combi-molecules"." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=112376.
Повний текст джерела