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Статті в журналах з теми "Novel marker"

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Автор: Grafiati

Опубліковано: 14 березня 2023

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1

Chen, Yingying, Jiafan Yang, Cunlei Cai, Junjie Shi, Yongxiang Song, Junying Ma, and Jianhua Ju. "Development of Marker Recycling Systems for Sequential Genetic Manipulation in Marine-Derived Fungi Spiromastix sp. SCSIO F190 and Aspergillus sp. SCSIO SX7S7." Journal of Fungi 9, no. 3 (February 26, 2023): 302. http://dx.doi.org/10.3390/jof9030302.

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Marine-derived fungi are emerging as prolific workhorses of structurally novel natural products (NPs) with diverse bioactivities. However, the limitation of available selection markers hampers the exploration of cryptic NPs. Recyclable markers are therefore valuable assets in genetic engineering programs for awaking silent SM clusters. Here, both pyrG and amdS-based recyclable marker cassettes were established and successfully applied in marine-derived fungi Aspergillus sp. SCSIO SX7S7 and Spiromastix sp. SCSIO F190, respectively. Using pyrG recyclable marker, a markerless 7S7-∆depH strain with a simplified HPLC background was built by inactivating a polyketide synthase (PKS) gene depH and looping out the pyrG recyclable marker after depH deletion. Meanwhile, an amdS recyclable marker system was also developed to help strains that are difficult to use pyrG marker. By employing the amdS marker, a backbone gene spm11 responsible for one major product of Spiromastix sp. SCSIO F190 was inactivated, and the amdS marker was excised after using, generating a relatively clean F190-∆spm11 strain for further activation of novel NPs. The collection of two different recycle markers will guarantee flexible application in marine-derived fungi with different genetic backgrounds, enabling the exploitation of novel structures in various fungi species with different genome mining strategies.

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2

Yongbin, Qi, Patcharaporn Summat, Natjaree Panyawut, Kannika Sikaewtung, Khanittha Ditthab, Keasinee Tongmark, Sriprapai Chakhonkaen, et al. "Identification of Rice Accessions Having Cold Tolerance at the Seedling Stage and Development of Novel Genotypic Assays for Predicting Cold Tolerance." Plants 12, no. 1 (January 3, 2023): 215. http://dx.doi.org/10.3390/plants12010215.

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Rice is susceptible to cold stress at the seedling stage, which can delay growth and decrease yield. We evaluated 187 rice accessions for cold tolerance at the seedling stage and developed genotypic assays for three markers. All japonica (20/20) and 20/140 indica accessions were highly cold tolerant. Two SNP markers specific for COLD1 and LOC_Os10g34840 were practical to use by normal agarose gel. The SNP marker specific for COLD1 was highly specific for predicting cold tolerance. However, the sensitivity of this marker was low as several cold-tolerant indica accessions lacked the cold-tolerant allele. The LOC_Os10g34840 marker was slightly more sensitive than the COLD1 marker for predicting highly cold-tolerant accessions. An insertion/deletion variant in the NAC6 gene was identified as a novel cold tolerance marker. The NAC6 marker predicted more highly cold-tolerant accessions compared with the other two markers. The SNP marker specific for LOC_Os10g34840 and the NAC6 marker were present in several tested subgroups, suggesting their wide effects and distribution. The three markers combined predicted the most highly cold-tolerant accessions, indicating that the marker combination is superior for applications such as marker-assisted breeding. The cold-tolerant accessions and the genotypic marker assays will be useful for future rice breeding.

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3

de Ridder, Mischa, Lara C. Gerbrandy, Theo M. de Reijke, Karel A. Hinnen, and Maarten C. C. M. Hulshof. "BioXmark® liquid fiducial markers for image-guided radiotherapy in muscle invasive bladder cancer: a safety and performance trial." British Journal of Radiology 93, no. 1111 (July 2020): 20200241. http://dx.doi.org/10.1259/bjr.20200241.

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Objective: This study evaluated the performance of the novel liquid fiducial marker (BioXmark®) in IGRT for bladder cancer. Methods: 20 patients with muscle invasive bladder cancer were entered in this prospective, single center, Phase I-II study. The novel BioXmark® liquid markers were injected around the tumor using a flexible cystoscopy. Visibility and stability of the markers were evaluated on planning-CT and CBCT. Prospectively defined threshold for success was set at a visibility of 75%. Results: In total, 76 markers were implanted in 20 patients. Of those, 60 (79% 95% CI ± 9%) were visible on CT scan. Due to the learning curve of the technique, the visibility improved in the last 75% of patients (86% visibility) compared to the first 25% of patients with 58% visibility. Concerning stability of the BioXmark® marker, all visible markers after CT acquisition were still detectable at the last CBCT without displacement. In 15/20 (75%) of the patients, three or more markers were visible on CT. No BioXmark® related adverse events were reported. Conclusion: The success rate of this novel fiducial marker was 79%, which is above the prospectively defined threshold rate. A distinct learning curve of the injection of the liquid marker was seen over the study period. The marker showed sustained visibility and positional stability during treatment phases and also appears to be safe and easy to inject. Advances in knowledge: This novel liquid BioXmark® marker seems to be a very promising tool in daily-adaptive IGRT for bladder preserving chemoradiotherapy in muscle invasive bladder cancer.

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4

Luukinen, Jean-Marc, Daniel Aalto, Jarmo Malinen, Naoko Niikuni, Jani Saunavaara, Päivi Jääsaari, Antti Ojalammi, Riitta Parkkola, Tero Soukka, and Risto-Pekka Happonen. "A Novel Marker Based Method to Teeth Alignment in MRI." Measurement Science Review 18, no. 2 (April 1, 2018): 79–85. http://dx.doi.org/10.1515/msr-2018-0012.

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AbstractMagnetic resonance imaging (MRI) can precisely capture the anatomy of the vocal tract. However, the crowns of teeth are not visible in standard MRI scans. In this study, a marker-based teeth alignment method is presented and evaluated. Ten patients undergoing orthognathic surgery were enrolled. Supraglottal airways were imaged preoperatively using structural MRI. MRI visible markers were developed, and they were attached to maxillary teeth and corresponding locations on the dental casts. Repeated measurements of intermarker distances in MRI and in a replica model was compared using linear regression analysis. Dental cast MRI and corresponding caliper measurements did not differ significantly. In contrast, the marker locationsin vivodiffered somewhat from the dental cast measurements likely due to marker placement inaccuracies. The markers were clearly visible in MRI and allowed for dental models to be aligned to head and neck MRI scans.

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5

Shapoval, S. D., I. L. Savon, L. V. Vasylevska, and M. M. Sofilkanych. "PRESEPSIN IS A NOVEL HIGHLY EFFECTIVE SEPSIS MARKER(REVIEW)." Modern medical technologies 44, no. 1 (March 1, 2020): 84–87. http://dx.doi.org/10.34287/mmt.1(44).2020.13.

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Abstract In this review the most effective markers of septic process like Procalcitonin, C-reactive protein, and cytokines compared to the new marker – Presepsin (PSP) are analyzed. At sepsis initiation, PSP increases 30 to 60 minutes after the onset of systemic infection. PSP levels at admission to the hospital predict the risk of adverse and adverse effects that other markers used for the diagnosis of sepsis do not have.

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6

Mortensen, Ole Hartvig, Anders Rinnov Nielsen, Christian Erikstrup, Peter Plomgaard, Christian Philip Fischer, Rikke Krogh-Madsen, Birgitte Lindegaard, Anne Marie Petersen, Sarah Taudorf, and Bente Klarlund Pedersen. "Calprotectin — A Novel Marker of Obesity." PLoS ONE 4, no. 10 (October 12, 2009): e7419. http://dx.doi.org/10.1371/journal.pone.0007419.

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7

Ordóñez, Nelson G. "Podoplanin: A Novel Diagnostic Immunohistochemical Marker." Advances in Anatomic Pathology 13, no. 2 (March 2006): 83–88. http://dx.doi.org/10.1097/01.pap.0000213007.48479.94.

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8

Rudnicka, M., D. Hinton, and C. A. Miller. "A NOVEL MARKER FOR OLIGODENDROGLIAL CELLS." Journal of Neuropathology and Experimental Neurology 48, no. 3 (May 1989): 363. http://dx.doi.org/10.1097/00005072-198905000-00193.

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9

Volk, Andrea L., and Gene P. Siegal. "MDA-7: a novel prognostic marker?" Advances in Anatomic Pathology 9, no. 5 (September 2002): 323. http://dx.doi.org/10.1097/00125480-200209000-00007.

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10

Deschamps, Kevin, Philip Roosen, Ivan Birch, Bart Dingenen, Herman Bruyninckx, Kaat Desloovere, Erwin Aertbelien, and Filip Staes. "A Novel Device for Standardizing Marker Placement at the Calcaneus." Journal of the American Podiatric Medical Association 104, no. 1 (January 1, 2014): 43–49. http://dx.doi.org/10.7547/0003-0538-104.1.43.

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Background The determination of anatomical reference frames in the rearfoot during three-dimensional multisegment foot modeling has been hindered by a variety of factors. One of these factors is related to the difficulty in palpating, or the absence of, anatomical landmarks. A novel device (the Calcaneal Marker Device) aimed at standardizing marker placement at the calcaneus was, therefore, developed and evaluated for its reliability. Methods Throughout a random repeated-measures design, the repeatability of calcaneal marker placement was evaluated for two techniques: manual placement and placement using the Calcaneal Marker Device. Translational changes after marker placement and the clinical effect on intersegment angle calculation were quantified. Results Intraobserver variability was greater in therapist 2 (<5.3 mm) compared with therapist 1 (<2.9 mm). Intraobserver variability was also found to be less than 1.6 mm throughout use of the device. Interobserver variability was found to be significantly higher for the position of markers placed manually (5.8 mm), whereas with the Calcaneal Marker Device, the variability remained lower (<1.3 mm). The effect on the computed intersegment angles followed a similar trend, with variability of 0.4° to 4.0° and 1.0° to 8.7° for CMD and manual placement, respectively. Conclusions These findings suggest that variations in marker placement are considerably reduced when the novel Calcaneal Marker Device is used, possibly toward the limits dictated by the fine motor skills of therapists and tissue artifacts.

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11

Kochar, Shruti, Neeraj Israni, Amol Kadu, and Shreya Shah. "Slit-lamp assisted TORic Marker (STORM): A novel corneal axis marker." Indian Journal of Ophthalmology 71, no. 3 (2023): 1057. http://dx.doi.org/10.4103/ijo.ijo_2779_22.

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12

Susylowati, Eka. "ASPEKTUALITAS DALAM NOVEL THE GREAT GATSBY OLEH F. SCOTT FITZGERALD." PRASASTI: Journal of Linguistics 4, no. 1 (May 11, 2019): 19. http://dx.doi.org/10.20961/prasasti.v4i1.28848.

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<p><em>This research aims to reveal the form and marker of aspectuality in The Great Gatsby novel written by F. Scott Fitzgerald. The data in this study are written data in the form of words, clauses, and sentences in the novel The Great Gatsby. It was written by F. Scott Fitzgerald consists of three forms of aspectuality namely perfective / completed, progressive, and repetitive / habitual. The aspect that is often used is perfective / completed aspiration. Aspectuality markers used including perfective aspect characterized by past verb or had + past participle verb, while progressive aspect are marked to be + verb ing, and repetitive / habitual are marked with past verb or infinitive forms.</em></p>

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13

Lauc, Gordan, Mirna Flögel, and Werner E. G. Müller. "Biotinylated Carbohydrate Markers -A Novel Tool for Lectin Research." Zeitschrift für Naturforschung C 49, no. 11-12 (December 1, 1994): 843–48. http://dx.doi.org/10.1515/znc-1994-11-1220.

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One of the key obstacles in lectin research is the lack of specific techniques for their detection. Novel markers, biotin-labeled carbohydrates, could contribute to overcome this problem. Being at least 10 times more sensitive than neoglycoproteins in the membranescreening assays, they also enable direct detection of lectins in complex mixtures. The markers were synthesized by linking biotin to one, and a carbohydrate (galactose or glucose) to the other amino group of (the amino acid) lysine. After synthesis the markers were chromatographically purified on lectin (RCA for galactose marker, ConA for glucose marker) and avidin affinity columns. The applicability of the markers to detect lectins was demonstrated e.g. with sponge extracts (from Geodia cydonium). Following incubation with biotin-labeled carbohydrates covalent cross-linking between lectins and markers was induced by UV radiation. After transfer to the blotting membrane, lectins were detected with deglycosylated antibiotin antibody labeled with alkaline phosphatase. Besides for the cross-linking technique, the biotinylated carbohydrate markers were also used for detection of lectins on the nitrocellulose membrane in gene library screening and slot blotting.

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14

Kovaleva, Olga V., Madina A. Rashidova, Daria V. Samoilova, Polina A. Podlesnaya, Rasul M. Tabiev, Valeria V. Mochalnikova, and Alexei Gratchev. "CHID1 Is a Novel Prognostic Marker of Non-Small Cell Lung Cancer." International Journal of Molecular Sciences 22, no. 1 (January 5, 2021): 450. http://dx.doi.org/10.3390/ijms22010450.

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There is an urgent need for identification of new prognostic markers and therapeutic targets for non-small cell lung cancer (NSCLC). In this study, we evaluated immune cells markers in 100 NSCLC specimens. Immunohistochemical analysis revealed no prognostic value for the markers studied, except CD163 and CD206. At the same time, macrophage markers iNOS and CHID1 were found to be expressed in tumor cells and associated with prognosis. We showed that high iNOS expression is a marker of favorable prognosis for squamous cell lung carcinoma (SCC), and NSCLC in general. Similarly, high CHID1 expression is a marker of good prognosis in adenocarcinoma and in NSCLC in general. Analysis of prognostic significance of a high CHID1/iNOS expression combination showed favorable prognosis with 20 months overall survival of patients from the low CHID1/iNOS expression group. For the first time, we demonstrated that CHID1 can be expressed by NSCLC cells and its high expression is a marker of good prognosis for adenocarcinoma and NSCLC in general. At the same time, high expression of iNOS in tumor cells is a marker of good prognosis in SCC. When used in combination, CHID1 and iNOS show a very good prognostic capacity for NSCLC. We suggest that in the case of lung cancer, tumor-associated macrophages are likely ineffective as a therapeutic target. At the same time, macrophage markers expressed by tumor cells may be considered as targets for anti-tumor therapy or, as in the case of CHID1, as potential anti-tumor agents.

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15

Alieva, A. M., A. V. Sozykin, N. V. Teplova, E. V. Reznik, D. V. Izimarieva, N. A. Novikova, I. V. Lozovsky, Е. E. Averin, R. K. Valiev, and I. G. Nikitin. "Tenascin-C as a cardiovascular marker." Russian Journal of Cardiology 27, no. 8 (September 3, 2022): 5150. http://dx.doi.org/10.15829/1560-4071-2022-5150.

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Novel biological markers, such as fibrosis marker galectin-3, peptide hormone adrenomedullin, soluble ST2, chemokine CX3CL1, surrogate marker of vasopressin, and others, are every year one step closer to being introduced into health practice. Over the past decades, significant progress has been made in the study of cardiovascular biomarkers. A key moment was the introduction of deter mining the concentration of natriuretic peptides used as markers for the diagnostic and prognostic evaluation of patients with heart failure. Currently, in order to search for novel markers for early diagnosis and risk stratification, studies have been conducted on the analysis of promising inflammatory marker tenascin-C (TNC) in cardiovascular patients. Data have been obtained that allow us to consider TNC as a tool for risk stratification and assessment of cardiovascular disease prognosis. The combination of TNC with other biological markers, in particular brain natriuretic peptide, may improve prognostic power. Nevertheless, serial testing to assess the prognosis and effectiveness of ongoing treatment, including in the conditions of a multimarker model, requires further research.

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16

Kane, Laura E., Gregory S. Mellotte, Eimear Mylod, Rebecca O'Brien, Fiona O'Connell, Khanh Nguyen, Croí E. Buckley, et al. "Abstract PO-008: Diagnostic accuracy of blood-based multi-omic biomarkers for pancreatic adenocarcinoma: A systematic review and meta-analysis." Cancer Research 81, no. 22_Supplement (November 15, 2021): PO—008—PO—008. http://dx.doi.org/10.1158/1538-7445.panca21-po-008.

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Abstract Background: Pancreatic ductal adenocarcinoma (PDAC) is the most lethal form of pancreatic cancer, being responsible for ~90% of all pancreatic cancers and having a 5-year survival rate of ~8.5%. The current clinical gold-standard for diagnosis of PDAC is the blood-based biomarker CA19-9. However, many studies have highlighted the limitations of CA19-9, specifically its relatively low sensitivity and specificity, and its inaccuracy in patients with certain underlying conditions. As such, there is an unmet need for robust diagnostic biomarkers for PDAC. Here, the diagnostic accuracy of all blood-based biomarkers examined in PDAC, reporting specifically on CA19-9, multi-marker panels containing CA19-9, novel single markers, and novel multi-marker panels for the diagnosis of PDAC. Methods: A systematic review of blood-based biomarkers for the diagnosis of PDAC was conducted in accordance with PRISMA standards. Individual search strategies using medical subject headings (MeSH) and ‘text words’ were developed for three academic databases: Medline, EMBASE and Web of Science. The 5,885 studies identified were subjected to two rounds of screening by two independent reviewers, with 250 studies being included in the meta-analysis. Data were extracted and assessed for bias using the QUADAS-2 Risk of Bias tool. Data were separated into two subgroups: those including CA19-9, and those without CA19-9 (novel). Patient cohorts examined were classified as “PDAC vs healthy”, “PDAC vs benign” and “PDAC vs mixed”. A multivariate three-level meta-analysis with subgroup moderators was run in R (v1.3.959) on all CA19-9 containing biomarker studies and subsequently on all novel biomarker studies, using reported AUC values as effect size. Results: Based on the three-level meta-analytic model, the pooled AUC value for CA19-9 alone (AUC=0.8473, 95% CI: 0.82-0.87) was significantly lower compared to the multi-marker panels containing CA19-9 (AUC=0.91, 95% CI:0.90-0.93) (p<0.0001). The estimated between-study variance in the model was I2Level 3= 63.55%, and the within-study variance was I2Level 2=36.45%. For the novel markers, the pooled AUC for single markers (AUC=0.79, 95% CI:0.75-0.83) was also significantly lower compared to novel multi-marker panels (AUC=0.87, 95% CI:0.85-0.89) (p<0.0001). Marker robustness was also influenced by the patient cohort examined, with CA19-9 markers performing best in all cohorts compared to novel markers; PDAC vs healthy (AUC=0.91, 95% CI:0.88-0.94), PDAC vs benign (AUC=0.85, 95% CI:0.84-0.87), and PDAC vs mixed (AUC=0.87, 95% CI:0.82-0.91) (p<0.0001). Conclusion: Overall, multi-marker panels show higher pooled AUC values than single markers, for both CA19-9 and novel datasets. Multi-marker panels containing CA19-9 demonstrate the most promising pooled AUC value, with CA19-9 alone performing inferiorly to novel multi-marker panels. These results indicate that CA19-9 may be best used as an addition to a panel of markers rather than alone, and that multi-marker panels ultimately generate the most robust results in a diagnostic capacity. Citation Format: Laura E. Kane, Gregory S. Mellotte, Eimear Mylod, Rebecca O'Brien, Fiona O'Connell, Khanh Nguyen, Croí E. Buckley, Jennifer Arlow, David Mockler, Aidan D. Meade, Barbara M. Ryan, Stephen G. Maher. Diagnostic accuracy of blood-based multi-omic biomarkers for pancreatic adenocarcinoma: A systematic review and meta-analysis [abstract]. In: Proceedings of the AACR Virtual Special Conference on Pancreatic Cancer; 2021 Sep 29-30. Philadelphia (PA): AACR; Cancer Res 2021;81(22 Suppl):Abstract nr PO-008.

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17

OROLE, Olukayode Olugbenga, Dooshima Ngulianga NEVKAA, Faith Chidinma TERNA, Alexander Lanzema OLOKUN, Jebes Ngolo LAMINI, and Oluwafemi Matthew SALAMI. "Biological Markers as a Novel Approach in Clinical Diagnosis and Management of Diseases." Journal of Drug Delivery and Therapeutics 10, no. 3-s (June 15, 2020): 341–47. http://dx.doi.org/10.22270/jddt.v10i3-s.4105.

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The adoption and use of biological marker also known as biomarkers in clinical studies and management of disease conditions spans over 40 years. Biological marker are measurable biochemical or molecular alterations that can be adopted as indicator of normal biological or responses to the action of pathogen or pharmacological responses to a therapeutic intervention. Molecules, macro and micro molecules, metabolites, and chemical compounds from the body adopted for use in predicting and monitoring health outcomes are constant from individual to another which qualify them as standard biomarker parameters. Use of biological markers spans clinical screening of an underlying cause of disease, prognosis, predisposition to a disease condition and predicting outcomes of treatment. In the environment, biological markers can be applied to determine the effects of xenobiotic chemicals and reaction effect on living cell. A good marker while being specific, should be easy to measure, cheap, provide correct measurement and outcomes. The objective of this review paper is highlight the different types of biological markers and areas where they are applicable.

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18

Thirumalai, Arthi, Fiona Yuen, John K. Amory, Andrew N. Hoofnagle, Ronald S. Swerdloff, Peter Y. Liu, Jill E. Long, Diana L. Blithe, Christina Wang, and Stephanie T. Page. "Dimethandrolone Undecanoate, a Novel, Nonaromatizable Androgen, Increases P1NP in Healthy Men Over 28 Days." Journal of Clinical Endocrinology & Metabolism 106, no. 1 (October 22, 2020): e171-e181. http://dx.doi.org/10.1210/clinem/dgaa761.

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Abstract Context Dimethandrolone undecanoate (DMAU) is being developed as a male contraceptive. Daily oral administration of DMAU, a potent androgen that is not aromatized, markedly suppresses serum testosterone (T) and estradiol (E2) in healthy men. E2 deficiency can increase bone resorption in men. Objective This work aimed to assess changes in bone turnover markers with DMAU administration in a 28-day study. Design A randomized, double-blind, placebo-controlled study was conducted. Setting This study took place at 2 academic medical centers. Participants Healthy men, age 18 to50 years (n = 81), participated. Intervention Men received 0, 100, 200, or 400 mg of oral DMAU for 28 days. Serum C-terminal telopeptide of type I collagen (CTX; bone resorption marker) and procollagen type I amino-terminal propeptide (P1NP; bone formation marker) were measured on days 1 and 28. Main Outcome Measures Changes in bone turnover markers and serum hormones over the treatment period were measured. Results On day 28, median serum T and E2 were markedly suppressed in all treatment groups vs placebo (P < .001 for both). Percentage change (%) in serum P1NP significantly differed across treatment groups (P = .007): Serum P1NP significantly increased in the 200 mg (5%, interquartile range [IQR] –7% to 27%) and 400 mg (22%, IQR –1% to 40%) groups relative to placebo (–8%, IQR –20% to 0%). Change (%) in serum CTX did not differ between groups (P = .09). Conclusions DMAU administration for 28 days to healthy men leads to marked suppression of serum T and E2, yet increases P1NP, a serum marker of bone formation. Longer-term studies of the potent androgen DMAU are warranted to determine its impact on bone health in men.

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19

Meslet-Cladière, Laurence, and Olivier Vallon. "Novel Shuttle Markers for Nuclear Transformation of the Green Alga Chlamydomonas reinhardtii." Eukaryotic Cell 10, no. 12 (October 14, 2011): 1670–78. http://dx.doi.org/10.1128/ec.05043-11.

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ABSTRACTThe green algaChlamydomonas reinhardtiitoday is a premier model organism for the study of green algae and plants. Yet the efficient engineering of its nuclear genome requires development of new antibiotic resistance markers. We have recoded, based on codon usage in the nuclear genome, the AadA marker that has been used previously for chloroplast transformation. The recoded AadA gene, placed under the control of theHSP70A-RBCS2hybrid promoter and preceded by the RbcS2 chloroplast-targeting peptide, can be integrated into the nuclear genome by electroporation, conferring resistance to spectinomycin and streptomycin. Transformation efficiency is markedly increased when vector sequences are completely eliminated from the transforming DNA. Antibiotic resistance is stable for several months in the absence of selection pressure. Shuttle markers allowing selection in bothChlamydomonasandEscherichia coliwould also be a useful asset. By placing an artificial bacterial promoter and Shine-Dalgarno sequence in frame within the AadA coding sequence, we generated such a shuttle marker. To our surprise, we found that the classical AphVIII construct already functions as a shuttle marker. Finally, we developed a method to introduce the AadA and AphVIII markers into the vector part of the bacterial artificial chromosomes (BACs) of theChlamydomonasgenomic DNA library. Our aim was to facilitate complementation studies whenever the test gene cannot be selected for directly. After transformation of apetCmutant with a modified BAC carrying the AphVIII marker along with thePETCgene in the insert, almost half of the paromomycin-resistant transformants obtained showed restoration of phototrophy, indicating successful integration of the unselected test gene. With AadA, cotransformation was also observed, but with a lower efficiency.

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20

Baumann, Raymond P., David H. Sherman, and Alan C. Sartorelli. "Novel Selection Marker for Mammalian Cell Transfection." BioTechniques 32, no. 5 (May 2002): 1030–36. http://dx.doi.org/10.2144/02325st03.

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21

Ochiya, Takahiro. "Secretory microRNA as a novel diagnostic marker." Drug Delivery System 26, no. 1 (2011): 10–14. http://dx.doi.org/10.2745/dds.26.10.

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22

Xin, Pan, Zeng Siliang, Cai Jialin, Zhang Bin, Pan Boju, Pan Zhonglei, Wu Ying, et al. "Screening novel diagnostic marker of Mycobacterium tuberculosis." African Journal of Microbiology Research 8, no. 8 (February 19, 2014): 776–82. http://dx.doi.org/10.5897/ajmr2013.6576.

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23

Tomita, N., T. Ohnishi, M. Tada, M. Ohue, M. Sekimoto, I. Sakita, Y. Tamaki, M. Monden, and K. Ohkubo. "A Novel Gene Marker for Colon Cancer." Nippon Daicho Komonbyo Gakkai Zasshi 51, no. 10 (1998): 1125–31. http://dx.doi.org/10.3862/jcoloproctology.51.1125.

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24

Doglioni, Claudio, Angelo P. Dei, Licia Laurino, Paolo Iuzzolino, Concetta Chiarelli, Marco R. Celio, and Giuseppe Viale. "Calretinin: A Novel Immunocytochemical Marker for Mesothelioma." American Journal of Surgical Pathology 20, no. 9 (September 1996): 1037–46. http://dx.doi.org/10.1097/00000478-199609000-00001.

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25

Yeung, Cecilia C. S., Jason C. Mills, Anjum Hassan, Frederike H. Kreisel, TuDung T. Nguyen, and John L. Frater. "MIST1—a Novel Marker of Plasmacytic Differentiation." Applied Immunohistochemistry & Molecular Morphology 20, no. 6 (December 2012): 561–65. http://dx.doi.org/10.1097/pai.0b013e31824e93f2.

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26

Simboeck, Elisabeth, and Luciano Di Croce. "HDAC1, a novel marker for benign teratomas." EMBO Journal 29, no. 23 (December 1, 2010): 3893–95. http://dx.doi.org/10.1038/emboj.2010.281.

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27

Bosevski, Marijan. "Carotid plaque typisation: a novel risk marker?" Heart 100, no. 1 (August 23, 2013): 79.1–79. http://dx.doi.org/10.1136/heartjnl-2012-303138.

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28

Toutouzas, Konstantinos, Maria Drakopoulou, Constantina Aggeli, Charalampia Nikolaou, Ioannis Felekos, Haralampos Grassos, Andreas Synetos, et al. "Carotid plaque typisation: a novel risk marker?" Heart 100, no. 1 (August 23, 2013): 79.2–80. http://dx.doi.org/10.1136/heartjnl-2013-304621.

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29

Jørgensen, D. R., M. Lillholm, and E. B. Dam. "A novel OA efficacy marker: cartilage activity." Osteoarthritis and Cartilage 21 (April 2013): S21—S22. http://dx.doi.org/10.1016/j.joca.2013.02.067.

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30

Beer, Martin, Ilona Reimann, Bernd Hoffmann, and Klaus Depner. "Novel marker vaccines against classical swine fever." Vaccine 25, no. 30 (July 2007): 5665–70. http://dx.doi.org/10.1016/j.vaccine.2006.12.036.

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31

Frank, Steven J., R. Jason Stafford, James A. Bankson, Chun Li, David A. Swanson, Rajat J. Kudchadker, and Karen S. Martirosyan. "A Novel MRI Marker for Prostate Brachytherapy." International Journal of Radiation Oncology*Biology*Physics 71, no. 1 (May 2008): 5–8. http://dx.doi.org/10.1016/j.ijrobp.2008.01.028.

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32

Clark, Amanda J., Haichun Yang, and Valentina Kon. "Urinary apoAl: novel marker of renal disease?" Pediatric Nephrology 34, no. 11 (August 11, 2019): 2425–26. http://dx.doi.org/10.1007/s00467-019-04328-1.

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33

Swain, Niharika, Shwetha V. Kumar, Samapika Routray, Jigna Pathak, and Shilpa Patel. "Podoplanin—a novel marker in oral carcinogenesis." Tumor Biology 35, no. 9 (June 27, 2014): 8407–13. http://dx.doi.org/10.1007/s13277-014-2266-5.

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34

Sayan, Berna S., Gulayse Ince, A. Emre Sayan, and Mehmet Ozturk. "NAPO as a novel marker for apoptosis." Journal of Cell Biology 155, no. 5 (November 19, 2001): 719–24. http://dx.doi.org/10.1083/jcb.200106044.

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Анотація:

Apoptosis or programmed cell death plays a pivotal role in embryonic development and maintenance of homeostasis. It is also involved in the etiology of pathophysiological conditions such as cancer, neurodegenerative, autoimmune, infectious, and heart diseases. Consequently, the study of apoptosis is now at center of both basic and clinical research applications. Therefore, sensitive and simple apoptosis detection techniques are required. Here we describe a monoclonal antibody–defined novel antigen, namely NAPO (negative in apoptosis), which is specifically lost during apoptosis. The anti-NAPO antibody recognizes two nuclear polypeptides of 60 and 70 kD. The antigen is maintained in quiescent and senescent cells, as well as in different phases of the cell cycle, including mitosis. Thus, immunodetection of NAPO antigen provides a specific, sensitive, and easy method for differential identification of apoptotic and nonapoptotic cells.

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35

Young, Shamar, Jeffrey Vogel, Sean Wiley, and James Caridi. "Transarterial Fiducial Marker Placement: A Novel Technique." Journal of Vascular and Interventional Radiology 24, no. 5 (May 2013): 756–58. http://dx.doi.org/10.1016/j.jvir.2013.01.011.

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36

Pierik, Frank, Alex Burdorf, Frank de Jong, and Robertus Weber. "Inhibin B: a novel marker of spermatogenesis." Annals of Medicine 35, no. 1 (January 2003): 12–20. http://dx.doi.org/10.1080/07853890310004084.

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37

Ogawa-Mitsuhashi, Kaoru, Koji Sagane, Junro Kuromitsu, Hiroshi Takagi, and Kappei Tsukahara. "MPR1as a novel selection marker inSaccharomyces cerevisiae." Yeast 26, no. 11 (November 2009): 587–93. http://dx.doi.org/10.1002/yea.1708.

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38

ASTUTI, SRI PUJI. "Kohesi dalam Novel Surat Kecil untuk Tuhan." Nusa: Jurnal Ilmu Bahasa dan Sastra 14, no. 3 (August 5, 2019): 364. http://dx.doi.org/10.14710/nusa.14.3.364-375.

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Анотація:

This study uses the Surat Kecil untuk Tuhan novel (NSK) as a data source. The language used in this novel is very interesting. Therefore, cohesion is used in this novel as a marker. This study aims to decipher lexical cohesion markers and grammatical cohesion markers used in the Surat Kecil untuk Tuhan. In collecting data, the researchers first listened to the use of the language used in the novel then continued with the note taking technique. The results of the analysis found that to form a coherent discourse the author of the Surat Kecil untuk Tuhan uses lexical cohesion markers and grammatical cohesion markers.

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39

Prihatini, Riry, Diny Dinarti, Agus Sutanto, and Sudarsono. "Development of Hermaphrodite Salacca (Salacca zalacca) SNAP Marker: A Novel Conservation Tool." IOP Conference Series: Earth and Environmental Science 1105, no. 1 (December 1, 2022): 012030. http://dx.doi.org/10.1088/1755-1315/1105/1/012030.

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Анотація:

Abstract Salacca (Salacca zalacca) or snake fruit is a tropical fruit, which is considered to be originated from Indonesia. One of the challenges in salacca conservation is the wide genetic diversity of the plants due to their natural cross-breeding. Most S. zalacca are dioecious plants by having fertile female and male flowers on different individuals, except for Salak Bali which is regarded to be monoecious. Morphological and cytogenetic markers have failed to differentiate the salacca plants’ sex types during the vegetative phase, thus the molecular marker is an alternative. We explored the specific salacca gene sequence on various sex types of salacca plants to identify sex-related single nucleotide polymorphism. The SNAP markers were then developed using the chosen SNP and validated on a total of 30 salacca samples. Nine samples of salacca’s female, male, and hermaphrodites were amplified using designed primers. The produced bands were sequenced and analyzed using Geneious Prime software. The analysis implied 9 SNPs on the 446 bp of salacca’s specific partial sequences. The SNAP markers were designed based on SNP validation showed that the marker potentially used a hermaphrodite-specific marker. The development of molecular markers as an early salacca sex type detection tool may be helpful in fruit cultivation, accelerating the plant breeding program, as well as on conservation management.

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40

Kirik, Heli, Lea Tummeleht, Tobias Lilja, and Olavi Kurina. "Novel Mitochondrial DNA Lineage Found among Ochlerotatus communis (De Geer, 1776) of the Nordic-Baltic Region." Insects 11, no. 6 (June 26, 2020): 397. http://dx.doi.org/10.3390/insects11060397.

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Анотація:

The Ochlerotatus (Oc.) communis complex consist of three Northern American species as well as a common Holarctic mosquito (Diptera: Culicidae) Oc. communis (De Geer, 1776). These sister species exhibit important ecological differences and are capable of transmitting various pathogens, but cannot always be differentiated by morphological traits. To investigate the Oc. communis complex in Europe, we compared three molecular markers (COI, ND5 and ITS2) from 54 Estonian mosquitoes as well as two COI marker sequences from Sweden. These sequences were subjected to phylogenetic analysis and screened for Wolbachia Hertig and Wolbach symbionts. Within and between groups, distances were calculated for each marker to better understand the relationships among individuals. Results demonstrate that a group of samples, extracted from adult female mosquitoes matching the morphology of Oc. communis, show a marked difference from the main species when comparing the mitochondrial markers COI and ND5. However, there is no variance between the same specimens when considering the nuclear ITS2. We conclude that Oc. communis encompasses two distinct mitochondrial DNA lineages in the Nordic-Baltic region. Further research is needed to investigate the origin and extent of these genetic differences.

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41

Chiawwit, Phatcharaporn, Monchanok Boonyahong, Unchana Thawornwan, Potjanee Srimanote, and Pongsri Tongtawe. "Identification of VPA1327 (vopT) as a Novel Genetic Marker for Detecting Pathogenic Vibrio parahaemolyticus." Journal of Pure and Applied Microbiology 12, no. 2 (June 30, 2018): 429–38. http://dx.doi.org/10.22207/jpam.12.2.01.

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42

Jawahar, Devi, Muruganantham Arunagirinathan, and Induja Murali. "CD 10: A Novel Stromal Marker in Pathogenesis and Prognosis of Invasive Breast Carcinoma." Annals of Pathology and Laboratory Medicine 7, no. 4 (April 29, 2020): A157–161. http://dx.doi.org/10.21276/apalm.2650.

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43

See, Pao Theen, and Caroline S. Moffat. "Evaluation of a Novel Molecular Marker Associated with the Tan Spot Disease Response in Wheat." Agriculture 11, no. 6 (June 1, 2021): 513. http://dx.doi.org/10.3390/agriculture11060513.

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Анотація:

After nearly 40 years of DNA molecular marker development in plant breeding, the wheat research community has amassed an extensive collection of molecular markers which have been widely and successfully used for selection of agronomic, physiological and disease resistance traits in wheat breeding programs. Tan spot is a major fungal disease of wheat and a significant global economic challenge and is caused by the necrotrophic fungal pathogen Pyrenophora tritici-repentis (Ptr). Here, the potential for using a PCR-based marker (Ta1AS3422) present on the short arm of wheat chromosome 1A, was evaluated for effectiveness in distinguishing tan spot disease susceptibility. The marker was initially screened against 40 commercial Australian hexaploid wheat varieties, and those that amplified the marker had an overall lower disease score (2.8 ± 0.7 for seedlings and 2.4 ± 0.4 for plants at the tillering stage), compared to those lacking the marker which exhibited a higher disease score (3.6 ± 0.8 for both growth stages). The potential of Ta1AS3422 as a marker for the tan spot disease response was further assessed against a panel of 100 commercial Australian hexaploid wheat varieties. A significant association was observed between marker absence/presence and tan spot disease rating (Pearson’s chi-squared test, χ2 (6) = 20.53, p = 0.002), with absence of Ta1AS3422 associated with susceptibility. This simple and cost-effective PCR-based marker may be useful for varietal improvement against tan spot, although further work is required to validate its effectiveness.

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44

Biller, Sebastian, Daniel Baumgarten, and Jens Haueisen. "A Novel Marker Design for Magnetic Marker Monitoring in the Human Gastrointestinal Tract." IEEE Transactions on Biomedical Engineering 58, no. 12 (December 2011): 3368–75. http://dx.doi.org/10.1109/tbme.2011.2166074.

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45

Hentges, Pierre, Benoit Van Driessche, Lionel Tafforeau, Jean Vandenhaute, and Antony M. Carr. "Three novel antibiotic marker cassettes for gene disruption and marker switching inSchizosaccharomyces pombe." Yeast 22, no. 13 (2005): 1013–19. http://dx.doi.org/10.1002/yea.1291.

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46

Signorelli, Rossana, Teresa Maidana Giret, Oliver Umland, Marco Hadisurya, Shweta Lavania, John Lalith Charles Richard, Ashley Middleton, et al. "ALCAM: A Novel Surface Marker on EpCAMlow Circulating Tumor Cells." Biomedicines 10, no. 8 (August 16, 2022): 1983. http://dx.doi.org/10.3390/biomedicines10081983.

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Background: Current strategies in circulating tumor cell (CTC) isolation in pancreatic cancer heavily rely on the EpCAM and cytokeratin cell status. EpCAM is generally not considered a good marker given its transitory change during Epithelial to Mesenchymal Transition (EMT) or reverse EMT. There is a need to identify other surface markers to capture the complete repertoire of PDAC CTCs. The primary objective of the study is to characterize alternate surface biomarkers to EpCAM on CTCs that express low or negligible levels of surface EpCAM in pancreatic cancer patients. Methods: Flow cytometry and surface mass spectrometry were used to identify proteins expressed on the surface of PDAC CTCs in culture. CTCs were grown under conditions of attachment and in co-culture with naïve neutrophils. Putative biomarkers were then validated in GEMMs and patient samples. Results: Surface proteomic profiling of CTCs identified several novel protein biomarkers. ALCAM was identified as a novel robust marker in GEMM models and in patient samples. Conclusions: We identified several novel surface biomarkers on CTCs expressed under differing conditions of culture. ALCAM was validated and identified as a novel alternate surface marker on EpCAMlow CTCs.

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47

Rajender, Singh, Kumarasamy Thangaraj, Nalini J. Gupta, N. Leelavathy, Deepa Selvi Rani, Renjini G. Nambiar, Vadivelu Kalavathy, et al. "A Novel Human Sex-Determining Gene Linked to Xp11.21-11.23." Journal of Clinical Endocrinology & Metabolism 91, no. 10 (October 1, 2006): 4028–36. http://dx.doi.org/10.1210/jc.2006-0950.

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Abstract Context: The molecular basis for about 70–80% of 46,XY sex-reversed females remains unexplained, because they carry normal copies of the genes (SRY, SOX9, DAX1, DMRT, SF1, WT1) involved in sex determination pathway. Objective: The objective of this study is to map the chromosomal locus responsible for an unexplained sex-reversed phenotype. Design: The study implemented a genome-wide scan using families with multiple sex-reversed individuals. Setting: The patients, along with the family members, were selected from different hospitals/reproductive centers. Participants: Sex-reversed individuals and their siblings and parents participated in the study. Main Outcome Measures: Identification of the chromosomal locus responsible for sex reversal in these families and sequence analysis of candidate genes were the main outcome measures. Results: Parametric linkage analysis revealed a maximum two-point LOD score of 5.70 with marker DXS991 (Xp11.21) and 4.57 with marker DXS1039 (Xp11.23-Xp11.22), and a multipoint LOD score of 5.77 with marker DXS991 and 5.22 with marker DXS1039. The two markers (DXS991 and DXS1039) with highest LOD score span approximately 3.41 cM (75.79–79.2 cM) on the short arm of the X-chromosome. Conclusion: Our findings provide evidence for a major susceptibility locus for sex reversal/gonadal dysgenesis on the short arm of the X-chromosome (Xp11.21-11.23). Furthermore, molecular exploration of the expression of candidate genes in the embryonic gonad/gonadal ridge will help in the identification of the underlying gene for sex reversal.

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48

Michael, Vincent Njung’e, Yuqing Fu, Swati Shrestha, and Geoffrey Meru. "A Novel QTL for Resistance to Phytophthora Crown Rot in Squash." Plants 10, no. 10 (October 6, 2021): 2115. http://dx.doi.org/10.3390/plants10102115.

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Анотація:

Phytophthora capsici Leonian causes significant yield losses in commercial squash (Cucurbita pepo) production worldwide. The deployment of resistant cultivars can complement integrated management practices for P. capsici, but resistant cultivars are currently unavailable for growers. Moderate resistance to Phytophthora crown rot in a selection of accession PI 181761 (C. pepo) (designated line #181761-36P) is controlled by three dominant genes (R4, R5 and R6). Introgression of these loci into elite germplasm through marker-assisted selection (MAS) can accelerate the release of new C. pepo cultivars resistant to crown rot, but these tools are currently unavailable. Here we describe the identification of a quantitative trait locus (QTL), molecular markers and candidate genes associated with crown rot resistance in #181761-36P. Five hundred and twenty-three SNP markers were genotyped in an F2 (n = 83) population derived from a cross between #181761-36P (R) and Table Queen (S) using targeted genotyping by sequencing. A linkage map (2068.96 cM) consisting of twenty-one linkage groups and an average density of 8.1 markers/cM was developed for the F2 population. The F2:3 families were phenotyped in the greenhouse with a virulent strain of P. capsica, using the spore-spray method. A single QTL (QtlPC-C13) was consistently detected on LG 13 (chromosome 13) across three experiments and explained 17.92–21.47% of phenotypic variation observed in the population. Nine candidate disease resistance gene homologs were found within the confidence interval of QtlPC-C13. Single nucleotide polymorphism (SNP) markers within these genes were converted into Kompetitive Allele Specific PCR (KASP) assays and tested for association with resistance in the F2 population. One SNP marker (C002686) was significantly associated with resistance to crown rot in the F2 population (p < 0.05). This marker is a potential target for MAS for crown rot resistance in C. pepo.

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Chaicharoen, Adcharapun, Suwaluk Amawan, Jeeraporn Kansup, Aroonothai Sawwa, and Krittaya Petchpoung. "Novel SNP Markers and Their Application in Low-Cyanide Cassava (Manihot esculenta crantz) Breeding Program." Trends in Sciences 20, no. 4 (January 19, 2023): 6456. http://dx.doi.org/10.48048/tis.2023.6456.

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Анотація:

The major flaw of cassava is its indigenous cyanide. Traditional breeding program for diminishing cyanide in cassava take a long waiting time for harvesting cassava tubers to assess cyanide content. Genetic markers are useful for selection of good agricultural traits, which also applied in low-cyanide cassava breeding programs by detecting gene associate with cyanide content in cassava. Therefore, the objective of this study was to develop SNP markers to detect low cyanide trait in cassava. Genotype analysis was carried out using Genotyping by Sequencing (GBS) technology assembling with phenotype analysis. Then, the SNP markers associated with cyanide content were found. Afterward, the primers of SNP marker associated with cyanide content 2 positions were developed using tetra-primer ARMS-PCR techniques. S16_640082 and S16_735381 SNP markers on chromosome 16 showed potential ability of the selection of cassava varieties with cyanide content less than 250 mg HCN/kg fresh weight. The selection accuracy of S16_640082 and S16_735381 SNP markers was 73.33 and 76.64 %, respectively. These markers could be used in marker assisted selection (MAS) in cassava seedling. It substantially reduces cassava breeding programs cost and time. HIGHLIGHTS The major flaw of cassava is its indigenous cyanide. Up to our knowledge, there is rarely report on SNP marker related to cyanide content in Thai cassava population By performing genome wide association mapping (GWAS) to characterize the genome position related to HCN, 2 novel SNP markers associated with cyanide content were found The primers to detect the SNP markers were developed using tetra-primer ARMS-PCR techniques The markers showed ability of the selection of cassava varieties with cyanide content less than 250 mg HCN/kg fresh weight GRAPHICAL ABSTRACT

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50

Huang, Zhaoyang, Xiaokun Pan, Weihong Pan, Weikang Bian, Yan Xu, Ka Chun Cheung, Guofeng Zhang, and Hongsheng Li. "NeuralMarker." ACM Transactions on Graphics 41, no. 6 (November 30, 2022): 1–10. http://dx.doi.org/10.1145/3550454.3555468.

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Анотація:

We tackle the problem of estimating correspondences from a general marker, such as a movie poster, to an image that captures such a marker. Conventionally, this problem is addressed by fitting a homography model based on sparse feature matching. However, they are only able to handle plane-like markers and the sparse features do not sufficiently utilize appearance information. In this paper, we propose a novel framework NeuralMarker, training a neural network estimating dense marker correspondences under various challenging conditions, such as marker deformation, harsh lighting, etc. Deep learning has presented an excellent performance in correspondence learning once provided with sufficient training data. However, annotating pixel-wise dense correspondence for training marker correspondence is too expensive. We observe that the challenges of marker correspondence estimation come from two individual aspects: geometry variation and appearance variation. We, therefore, design two components addressing these two challenges in NeuralMarker. First, we create a synthetic dataset FlyingMarkers containing marker-image pairs with ground truth dense correspondences. By training with FlyingMarkers, the neural network is encouraged to capture various marker motions. Second, we propose the novel Symmetric Epipolar Distance (SED) loss, which enables learning dense correspondence from posed images. Learning with the SED loss and the cross-lighting posed images collected by Structure-from-Motion (SfM), NeuralMarker is remarkably robust in harsh lighting environments and avoids synthetic image bias. Besides, we also propose a novel marker correspondence evaluation method circumstancing annotations on real marker-image pairs and create a new benchmark. We show that NeuralMarker significantly outperforms previous methods and enables new interesting applications, including Augmented Reality (AR) and video editing.

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