Добірка наукової літератури з теми "NOTCH 1 Intracellular Domain Indicate"
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Статті в журналах з теми "NOTCH 1 Intracellular Domain Indicate"
Kitagawa, Motoo, Toshinao Oyama, Taichi Kawashima, Barry Yedvobnick, Anumeha Kumar, Kenji Matsuno, and Kenichi Harigaya. "A Human Protein with Sequence Similarity to DrosophilaMastermind Coordinates the Nuclear Form of Notch and a CSL Protein To Build a Transcriptional Activator Complex on Target Promoters." Molecular and Cellular Biology 21, no. 13 (July 1, 2001): 4337–46. http://dx.doi.org/10.1128/mcb.21.13.4337-4346.2001.
Повний текст джерелаBlokzijl, Andries, Camilla Dahlqvist, Eva Reissmann, Anna Falk, Annalena Moliner, Urban Lendahl та Carlos F. Ibáñez. "Cross-talk between the Notch and TGF-β signaling pathways mediated by interaction of the Notch intracellular domain with Smad3". Journal of Cell Biology 163, № 4 (24 листопада 2003): 723–28. http://dx.doi.org/10.1083/jcb.200305112.
Повний текст джерелаChandiran, Karthik, and Lisa M. Minter. "Notch-1 regulation of microRNAs alter the expression of proinflammatory cytokines and Th1 response." Journal of Immunology 196, no. 1_Supplement (May 1, 2016): 127.1. http://dx.doi.org/10.4049/jimmunol.196.supp.127.1.
Повний текст джерелаKoshizaka, Masaya, Minoru Takemoto, Seiya Sato, Hirotake Tokuyama, Masaki Fujimoto, Emiko Okabe, Ryoichi Ishibashi, et al. "An Angiotensin II Type 1 Receptor Blocker Prevents Renal Injury via Inhibition of the Notch Pathway in Ins2 Akita Diabetic Mice." Experimental Diabetes Research 2012 (2012): 1–10. http://dx.doi.org/10.1155/2012/159874.
Повний текст джерелаNobta, Masuhiro, Tomoo Tsukazaki, Yasuaki Shibata, Chang Xin, Takeshi Moriishi, Seiji Sakano, Hiroyuki Shindo, and Akira Yamaguchi. "Critical Regulation of Bone Morphogenetic Protein-induced Osteoblastic Differentiation by Delta1/Jagged1-activated Notch1 Signaling." Journal of Biological Chemistry 280, no. 16 (February 4, 2005): 15842–48. http://dx.doi.org/10.1074/jbc.m412891200.
Повний текст джерелаKusano, Shuichi, and Nancy Raab-Traub. "An Epstein-Barr Virus Protein Interacts with Notch." Journal of Virology 75, no. 1 (January 1, 2001): 384–95. http://dx.doi.org/10.1128/jvi.75.1.384-395.2001.
Повний текст джерелаKim, Su Hwan, Jin Hyun Kang, Tae Ki Uhm, Do Jin Kim, and Il Yup Chung. "Notch signaling promotes MUC5AC expression through epidermal growth factor receptor-extracellular regulated kinase pathway (163.1)." Journal of Immunology 186, no. 1_Supplement (April 1, 2011): 163.1. http://dx.doi.org/10.4049/jimmunol.186.supp.163.1.
Повний текст джерелаHoebeke, Inge, Magda De Smedt, Inge Van de Walle, Katia Reynvoet, Greet De Smet, Jean Plum, and Georges Leclercq. "Overexpression of HES-1 is not sufficient to impose T-cell differentiation on human hematopoietic stem cells." Blood 107, no. 7 (April 1, 2006): 2879–81. http://dx.doi.org/10.1182/blood-2005-05-1815.
Повний текст джерелаKindler, Thomas, Melanie G. Cornejo, Claudia Scholl, Jianing Liu, Dena S. Leeman, J. Erika Haydu, Stefan Fröhling, Benjamin H. Lee та D. Gary Gilliland. "K-RasG12D–induced T-cell lymphoblastic lymphoma/leukemias harbor Notch1 mutations and are sensitive to γ-secretase inhibitors". Blood 112, № 8 (15 жовтня 2008): 3373–82. http://dx.doi.org/10.1182/blood-2008-03-147587.
Повний текст джерелаWallberg, Annika E., Kia Pedersen, Urban Lendahl, and Robert G. Roeder. "p300 and PCAF Act Cooperatively To Mediate Transcriptional Activation from Chromatin Templates by Notch Intracellular Domains In Vitro." Molecular and Cellular Biology 22, no. 22 (November 15, 2002): 7812–19. http://dx.doi.org/10.1128/mcb.22.22.7812-7819.2002.
Повний текст джерелаДисертації з теми "NOTCH 1 Intracellular Domain Indicate"
Petit-Paitel, Agnès. "Étude du rôle des présénilines dans la maturation de la protéine précurseur du peptide amyloi͏̈de dans la maladie d'Alzheimer et dans la maturation du récepteur Notch-1 : une fonction controversée." Paris 7, 2002. http://www.theses.fr/2002PA077149.
Повний текст джерелаKUAN, YU-HSIN, and 官予馨. "To investigate the proliferation mechanism of hMSC by transducing Notch 1 intracellular domain-coupled magnetic nanoparticle." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/k66q4j.
Повний текст джерела國立中正大學
化學工程研究所
106
Notch family proteins play an important role in cell proliferation, differentiation, and apoptosis. The intracellular domain of activated Notch 1 receptor (NICD) can form complexes with transcription factors of the CSL family, resulting in subsequent activation of downstream target genes: Myc, p21, and the HES family. In this study, glutathione (GSH)-bound superoxide paramagnetic iron oxide nanoparticles (SPION@SiO2-MA-GSH) were prepared, and then separately coupled with the various lengths of Notch 1 intracellular domain fragments: N1IC, RA, and ANK via the interaction of GSH and GST-tagged proteins. Impulsed magnetic field was employed to deliver these protein-magnetic nanoparticle conjugates to human mesenchymal stem cells (hMSC) derived from bone marrow. After a culture for two days, the cell viability was measured by MTT assay. Then the regulated effect of NICD fragment to downstream gene and protein were checked by RT-PCR and Western-Blot respectively. The results show that the cell viability of hMSC was most significantly enhanced by transduction with N1IC-coupled SPION@SiO2-MA-GSH. The cell viability was improved from 100% to 139.63±19.69 %, which was than those transduced with conjugates of RA and ANK, 123.64±12.95 and 109.57±10.93 respectively, suggesting that the activation of downstream gene of N1IC caused hMSC to proliferate. From the results of RT-PCR and Western-Blot, we found that the expression level of HES 1 gene in transduced hMSC was much higher than that non-transduced hMSC. The higher HES 1 expression level resulted in the enhanced expression of phosphorylated-Akt protein, and then consequently promoted the proliferation of hMSC.
Yu, Ching-ping, and 于青平. "Promote the directed differentiation of mesenchymal stem cells by the transduction of Notch-1 intracellular domain using magnetic nanoparticles." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/75495558410076850980.
Повний текст джерела國立中正大學
化學工程所
95
Notch signaling has been shown to play an important role in cell proliferation and differentiation, as well as in cell-fate decision. Previous studies revealed that the transfection of Notch-1 intracellular domain (N1IC) could impair osteoblast differentiation and enhance adipogenesis in culture of stromal cells from murine bone marrow, and that bone marrow stromal cells from both rat and human sources can be induced to differentiate into cells with neuronal characteristics using gene transfection with N1IC and subsequent with certain trophic factors. Our study consists of two major parts. We first investigated Notch express in mesenchymal stem cell (MSC) and liver cells. We found that the Notch expression decreased during the differentiation from MSCs into liver cells, while Notch was expressed in both normal and liver tumor tissues. According to these results, we used a high efficient method for the transduction of MSCs with protein of N1IC and investigated the role of N1IC in the in vitro differentiation. The results suggest that N1IC has different roles in different differentiated cells. The transduction of N1IC could enhance the proliferation of MSCs and maintain MSCs in the state of progenitor. The transduced N1IC could also promote bone differentiation of MSCs.
Mungamuri, Sathish Kumar. "Notch1-Induced Survival Signaling And Its Implications In Cancer Therapeutics." Thesis, 2006. http://hdl.handle.net/2005/455.
Повний текст джерелаЧастини книг з теми "NOTCH 1 Intracellular Domain Indicate"
Hasan, Sana S., and Andreas Fischer. "Notch Signaling in Familial Cerebral Cavernous Malformations and Immunohistochemical Detection of Cleaved Notch1 Intracellular Domain." In Methods in Molecular Biology, 427–35. New York, NY: Springer US, 2020. http://dx.doi.org/10.1007/978-1-0716-0640-7_31.
Повний текст джерелаТези доповідей конференцій з теми "NOTCH 1 Intracellular Domain Indicate"
Jorgensen, M. J., MJ Rabiet, A. B. Cantor, B. Furie, C. L. Brown, C. B. Shoemaker та B. C. Furie. "VITAMIN K-DEPENDENT γ-CARBOXYLATION OF FACTOR IX REQUIRES A RECOGNITION SITE CONTAINED WITHIN THE PROPEPTIDE". У XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643564.
Повний текст джерела