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Дисертації з теми "NF-kappa B pathway"

Автор: Grafiati

Опубліковано: 11 березня 2023

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1

陳俊峯 and Chun-fung Anthony Chan. "Dysregulation of nuclear factor-kappa B (NF-KB) signaling pathway in hepatocellular carcinoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B31227156.

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2

Lupica, Joseph A. "Inhibition of the NF-kB signaling pathway and its effects on apoptosis and cancer." Cleveland, Ohio : Cleveland State University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=csu1214235115.

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Thesis (Ph.D.)--Cleveland State University, 2008.<br>Abstract. Title from PDF t.p. (viewed on Oct. 6, 2008). Includes bibliographical references (p. 213-240). Available online via the OhioLINK ETD Center. Also available in print.

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3

Guo, Xiaoxia. "Nuclear Factor Kappa B Pathway and human cancer therapeutics." Thesis, University of Wolverhampton, 2009. http://hdl.handle.net/2436/88553.

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Cancer is one of the major causes of morbidity in the world. Although the overall survival of cancer has been significantly improved by chemotherapy in the last three decades, the success of cancer chemotherapy is still severely limited by the lack of selectivity of anti-cancer drugs to malignant cells leading to dose-limiting toxicity and the resistance of cancer cells to the conventional anti-cancer drugs. Gene-directed enzyme prodrug therapy (GDEPT) was designed to direct the anti-cancer drugs to specifically target the cancer cells by using cancer specific promoter to drive the expression

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4

Sunami, Yoshiaki. "Molecular analysis of the non-canonical NF-kappaB pathway." Université Louis Pasteur (Strasbourg) (1971-2008), 2006. http://www.theses.fr/2006STR13177.

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On a montré ici que les voies canonique/non-canonique de NF-B ne sont pas indépendantes et qu’un rôle principal de la voie canonique est l’activation des acteurs de la voie non-canonique. La traduction est requise et la stimulation par LPS régule positivement un éventuel intermédiaire dans la signalisation par LPS/CD40 qui supporte l'activation de la voie non-canonique. De plus, la voie non-canonique est constitutivement activée dans les cellules de HL, impliquant la phosphorylation persistante de p100. L'activation transitoire et constitutive de la voie non-canonique implique l'incorporation

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5

Torrie, Lindsay J. "Characterisation of the lipopolysaccharide stimulated NF#kappa#B signal transduction pathway in rat aortic smooth muscle cell." Thesis, University of Strathclyde, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249146.

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6

Konieczkowski, David Joseph. "Systematic approaches to overcoming limitations of MAPK pathway inhibition in melanoma." Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:11094.

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Metastatic melanoma is an aggressive, incurable cancer with historically few therapeutic options. The discovery that 60% of melanomas harbor the oncogenic BRAF_V600E mutation, which constitutively activates the MAPK pathway, has provided a promising new therapeutic axis. Although MAPK pathway inhibitor therapy has shown striking clinical results in BRAF_V600-mutant melanoma, this approach faces three limitations. First, 10-20% of BRAF_V600-mutant melanomas never achieve meaningful response to MAPK pathway inhibitor therapy (intrinsic resistance). Second, among BRAF_V600-mutant melanomas in

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7

Bu, De-xiu. "The nuclear factor k[kappa]B signal transduction pathway : its role in atherogenesis and intimal hyperplasia /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-615-8/.

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8

Cai, Chunhui, and 蔡春晖. "TAK1 promotes ovarian cancer aggressiveness through activation of NF-kB pathway." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/193410.

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Ovarian cancer is one of the most deadly female malignancies. Despite advances in the treatment of ovarian cancer for the past decade, the cure rate of this disease is moderately improved. Emerging evidence suggests the molecular personalized therapeutic approach become popular for human cancer treatment. The nuclear factor-kappa B (NF-κB) signaling pathway has been shown to play multiple roles in cancer progression such as anti-apoptosis, cell cycle, angiogenesis and metastasis. This study attempted to characterize the functional roles of transforming growth factor (TGF)-β-activating kinase 1

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9

Shaikh, Raziya Banu. "Light related TNF cytokines and the NF-[kappa]B pathway in development and function of mucosal and NK T cells /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2003. http://wwwlib.umi.com/cr/ucsd/fullcit?p3091315.

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10

Cude, Kelly J. "Activation of a novel ERK5-NF-kappaB pathway is required for G2/M progression in the cell cycle /." Thesis, Connect to this title online; UW restricted, 2004. http://hdl.handle.net/1773/5003.

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11

Ryan, Sarah-Louise. "Targeting the nuclear factor kappa-light-chain-enhancer of activated b cells (NF-kb) pathway to overcome cisplatin-resistance in non-small cell lung cancer." Thesis, Queensland University of Technology, 2019. https://eprints.qut.edu.au/127346/1/Sarah-Louise_Ryan_Thesis.pdf.

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This project contributed to a greater understanding of chemotherapy resistance in non-small cell lung cancer (NSCLC), a prevalent issue to chemotherapy. The potential of the inflammatory transcription factor NF-ĸB as a therapeutic target was investigated to combat NSCLC chemo-resistance using in vitro and in vivo approaches. The activity of NF-ĸB was elucidated in models of chemo-resistant NSCLC and where specific inhibitors of NF-ĸB were used to block activity. In addition, a novel 3D model of chemo-resistance in NSCLC was generated which will serve as an important model in fut

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12

Lacey, Derek. "NFκB independent pathway activation of rheumatoid arthritis FLS by macrophage migration inhibitory factor (MIF)". Monash University, Faculty of Medicine, 2003. http://arrow.monash.edu.au/hdl/1959.1/9457.

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13

Mazzone, Graciela Lujan. "Role of unconjugated bilirubin in the endothelial dysfunction." Doctoral thesis, Università degli studi di Trieste, 2008. http://hdl.handle.net/10077/2647.

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2006/2007<br>Atherosclerosis, a progressive cardiovascular disease, is characterized by the accumulation of cholesterol in macrophage deposits (foam cells) and the formation of atherosclerotic plaques in the walls large- and medium- sized arteries. The earliest events in the development of atherosclerosis involve progressive modifications in the endothelial micro-environment. This endothelial dysfunction is a complex of multi-step mechanisms, for which reduced NO levels have been reported as a marker, is characterized by increasing expression of adhesion molecules (AMs), which mediate the diap

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14

Lee, Thomas H. "The Role of RIP1 in the TNFR1 Signal Transduction Pathway: a Dissertation." eScholarship@UMMS, 2004. http://escholarship.umassmed.edu/gsbs_diss/235.

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The cytokine tumor necrosis factor α (TNFα) stimulates the NF-кB, SAPK/JNK, and p38 mitogen-activated protein (MAP) kinase pathways by recruiting Rip1 and Traf2 proteins to the tumor necrosis factor receptor 1 (TNFR1). Genetic studies have revealed that Rip1 links the TNFR1 to the IкB kinase (IKK) complex, whereas Traf2 couples the TNFR1 to the SAPK/JNK cascade. We found TNFα-induced p38 MAP kinase activation and interleukin-6 (IL-6) production is impaired in rip1-/- murine embryonic fibroblasts (MEF) but unaffected in traj2-/- MEF, demonstrating that Rip1 is also a specific mediator

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15

Catley, Matthew Copeland. "The role of NF-kappa B in inflammatory gene expression in pulmonary A549 cells : transduction pathways and mechanisms." Thesis, Imperial College London, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.404397.

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16

Zhong, Cai-Yun. "Regulation of MAPK/AP-1 and NF-[kappa]B signal pathways in tobacco smoke-induced pulmonary cell proliferation and apoptosis /." For electronic version search Digital dissertations database. Restricted to UC campuses. Access is free to UC campus dissertations, 2005. http://uclibs.org/PID/11984.

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Thesis (Ph. D.)--University of California, Davis, 2005.<br>Degree granted in Comparative Pathology. On t.p. "[kappa]" appears as Greek letter. Also available via the World Wide Web. (Restricted to UC campuses)

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17

Astarci, Erhan. "Investigation Of The Inflammatory Pathways In Spontaneously Differentiating Caco-2 Cells." Phd thesis, METU, 2011. http://etd.lib.metu.edu.tr/upload/12613507/index.pdf.

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Intestinal epithelial differentiation entails the formation of highly specialized cells with specific absorptive, secretory, digestive and immune functions. Cell-cell and cell-microenvironment interactions appear to be crucial in determining the outcome of the differentiation process. Using the Caco-2 cell line that can undergo spontaneous differentiation when grown past confluency, we observed a loss of VCAM1 (vascular cell adhesion molecule-1) expression while ICAM1 (intercellular cell adhesion molecule-1) expression was seen to be stable in the course of differentiation. Protein kinase C th

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18

Huang, Xuesong. "The study on signal mechanism of protein kinase C zeta-involved NF-kB activation in LPS-stimulated TLR4 signaling pathways." Connect to Online Resource-OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=mco1193663177.

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Dissertation (Ph.D.)--University of Toledo, 2007.<br>"In partial fulfillment of the requirements for the degree of Doctor of Philosophy in Biomedical Sciences." Title from title page of PDF document. Bibliography: p. 72-96.

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19

Fears, Sharry L. "Effect of Inhibition of S-Nitrosoglutathione Reductase on the NF-κB Pathway". Thesis, 2009. http://hdl.handle.net/1805/1949.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>S-nitrosoglutathione reductase (GSNOR) also known as glutathione- dependent formaldehyde dehydrogenase (FDH), is a zinc-dependent dehydrogenase. GSNOR oxidizes long chain alcohols to an aldehyde with the help of a molecule of NAD+. GSNOR was initially identified as FDH because of its role in the formaldehyde detoxification pathway. The only S-nitrosothiol (SNO) substrate recognized by GSNOR is GSNO. A transnitrosation reaction transfers NO from nitrosylated proteins or S-nitrosothiols (RSNO) to glutathione to form S-nitrosoglutathion

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20

Moulakakis, Christina [Verfasser]. "Pulmonary surfactant protein A's anti-inflammatory modulation of the IκB-α [I-kappa-B-alpha], NF-κB [NF-kappa-B] signal transduction pathway / vorgelegt von Christina Moulakakis". 2008. http://d-nb.info/990817296/34.

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21

De, Silva Nilushi. "The alternative NF-kB pathway in mature B cell development." Thesis, 2015. https://doi.org/10.7916/D8125RZK.

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The nuclear factor-kB (NF-kB) signaling cascade is comprised of two branches, the canonical and alternative NF-kB pathways. Signaling through the alternative NF-kB pathway culminates in the activation of the downstream transcription factor subunits, RELB and NF-kB2. The biological roles of RELB and NF-kB2 within the B cell lineage have been obscured in constitutional knockout mice by the diverse functions of these subunits in non-B cell types. To overcome these limitations, conditional alleles were generated to investigate the roles of RELB and NF-kB2 in B cell development. These alleles allow

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22

Yao, Chen [Verfasser]. "Activation of NF-k63B [NF-kappa-B] via the canonical pathway in nephrotoxic serum nephritis in mice : possible therapeutic applications with specific IKKDβ, [IKKD-beta], IKK2 inhibition / vorgelegt von Chen Yao". 2010. http://d-nb.info/1009348531/34.

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23

Lucas, Bethany R. "Ectopic expression of TAL-1 increases resistance to TNF[alpha]-induced apoptosis in Jurkat cells via changes in the NF-kB signaling pathway." 2011. http://liblink.bsu.edu/uhtbin/catkey/1642170.

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TAL-1, ectopically expressed in 60% of T-cell acute lymphoblastic leukemia (T-ALL) patients, may contribute to poor chemotherapy response. This research sought to determine if TAL-1 influences expression of proteins involved in the NF-kB signaling pathway and thus, resistance to cell death. NF-kB, IKKy, and TRAF-2 expression levels were found to be TAL-1 dependent. Cell death levels were higher in staurosporine-treated cells compared to tumor necrosis factor a-treated or dual-treated cells. TAL-1, NF-kB, IKKy, and TRAF-2 expression levels were elevated in tumor necrosis factor a-treated ce

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24

"Deregulated NF-κB signalling pathways in EBV-positive nasopharyngeal carcinoma". 2011. http://library.cuhk.edu.hk/record=b5894717.

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Lou, Pak Kin.<br>Thesis (M.D.)--Chinese University of Hong Kong, 2011.<br>Includes bibliographical references (leaves 136-170).<br>Abstracts in English and Chinese.<br>Abstract --- p.i<br>Acknowledgements --- p.v<br>Table of Contents --- p.vi<br>List of Figures --- p.x<br>List of Tables --- p.xiii<br>List of Publications --- p.xv<br>Chapter Chapter 1 --- Introduction --- p.1<br>Chapter 1.1. --- Aims of Study --- p.1<br>Chapter 1.2. --- Literature Review --- p.2<br>Chapter 1.2.1. --- Nasopharyngeal Carcinoma --- p.2<br>Chapter 1.2.1.1. --- Overview --- p.2<br>Chapter 1.2.1.2. --- His

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25

Shakibaei, M., A. Mobasheri, C. Lueders, F. Busch, P. Shayan, and A. Goel. "Curcumin enhances the effect of chemotherapy against colorectal cancer cells by inhibition of NF-kappaB and Src protein kinase signaling pathways." 2013. http://hdl.handle.net/10454/6183.

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OBJECTIVE: Development of treatment resistance and adverse toxicity associated with classical chemotherapeutic agents highlights the need for safer and effective therapeutic approaches. Herein, we examined the effectiveness of a combination treatment regimen of 5-fluorouracil (5-FU) and curcumin in colorectal cancer (CRC) cells. METHODS: Wild type HCT116 cells and HCT116+ch3 cells (complemented with chromosome 3) were treated with curcumin and 5-FU in a time- and dose-dependent manner and evaluated by cell proliferation assays, DAPI staining, transmission electron microscopy, cell cycle analys

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26

Busch, F., A. Mobasheri, P. Shayan, C. Lueders, R. Stahlmann, and M. Shakibaei. "Resveratrol modulates interleukin-1beta-induced phosphatidylinositol 3-kinase and nuclear factor kappaB signaling pathways in human tenocytes." 2012. http://hdl.handle.net/10454/5903.

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Resveratrol, an activator of histone deacetylase Sirt-1, has been proposed to have beneficial health effects due to its antioxidant and anti-inflammatory properties. However, the mechanisms underlying the anti-inflammatory effects of resveratrol and the intracellular signaling pathways involved are poorly understood. An in vitro model of human tenocytes was used to examine the mechanism of resveratrol action on IL-1beta-mediated inflammatory signaling. Resveratrol suppressed IL-1beta-induced activation of NF-kappaB and PI3K in a dose- and time-dependent manner. Treatment with resveratrol enhan

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