Дисертації з теми "Newborn infants Diseases Prevention"
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溫錫剛 and Shek-kong Thomas Wan. "Neutrophil function tests in Chinese newborn infants." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1991. http://hub.hku.hk/bib/B43893363.
Повний текст джерелаWang, Ding. "Application of mass spectrometry in enzyme deficiency assay for newborn screening purpose /." Thesis, Connect to this title online; UW restricted, 2006. http://hdl.handle.net/1773/11557.
Повний текст джерелаOliver, Lawrence Tommy Victor. "Study on factors associated with low birth weight babies at Uitenhage Hospital." Thesis, University of the Western Cape, 2000. http://etd.uwc.ac.za/index.php?module=etd&.
Повний текст джерелаZhao, Qian Sissi, and 赵茜. "The impact of human behaviors on healthcare-associated infections in neonatal intensive care unit: systematicreview." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B46944175.
Повний текст джерелаPikora, Cheryl A. "Type-Specific Immunity in HIV-1 Vertically Infected Infants." eScholarship@UMMS, 1995. https://escholarship.umassmed.edu/gsbs_diss/83.
Повний текст джерелаZanchim, Camila Cristina [UNESP]. "Identificação das áreas com maior risco de morbimortalidade neonatal a partir de geoprocessamento." Universidade Estadual Paulista (UNESP), 2013. http://hdl.handle.net/11449/98420.
Повний текст джерелаA vigilância da mortalidade infantil e fetal é uma das prioridades do Ministério da Saúde. Contribui para o cumprimento dos compromissos assumidos pelo Governo Brasileiro em defesa da criança, tais como o Objetivo de Desenvolvimento do Milênio, o Pacto pela Redução da Mortalidade Neonatal; o Pacto pela Vida e, mais recentemente, o Programa Mais Saúde e Rede Cegonha. O objetivo geral deste estudo foi identificar as áreas do município de Botucatu/SP, com maior concentração de recém-nascidos classificados como com risco de adoecer ou morrer, considerando-se o ano de 2010 e utilizando técnicas de geoprocessamento. Para análise de dados, buscou-se identificar as ocorrências por setor censitário, relacionandoas a condições sociais e ambientais. Trata-se de estudo observacional de caráter analítico. Foram utilizados como fonte de dados: o Sistema de Informações de Nascidos Vivos e informações sobre condições sociais e ambientais obtidas do banco de dados do Censo Demográfico 2010 para o município de Botucatu. Como resultados do estudo foram identificados um agrupamento alto (Jardim Riviera e Jardim Santa Elisa) e outro baixo (Jardim Paraíso II e Jardim Altos do Paraíso), áreas com grande e pequeno número de casos, respectivamente. Nenhuma relação dos casos com condições ambientais foi identificada. Quanto às condições sociais, as análises encontraram associação entre renda e risco social. Ausência de companheiro e idade materna inferior a 19 anos foram importantes fatores de risco neonatal no município. Concluiu-se que o município de Botucatu é homogêneo para questões ambientais, não havendo associação entre estas e o risco do recém-nascido. A renda foi o único fator capaz de captar eventuais desigualdades existentes, influenciando indiretamente na classificação de risco do neonato ao nascer. Mostrou-se necessário o desenvolvimento de ações que incentivem a...
Surveillance on child and fetal mortality is one of the priorities of the Ministry of Health. It contributes to the fulfillment of commitments taken by the Brazilian Government for children’s defense, such as the Millennium’s Development Objective; Agreement for Reduction of Neonatal Mortality; Agreement for Life and, more recently, the Mais Saúde and Rede Cegonha Programs. The goal of this study is to identify areas in the city of Botucatu/SP with a higher concentration of newborns classified as at risk for falling ill or dying by considering the year of 2010 and using geoprocessing techniques. For data analysis, was sought to identify occurrences per census tract, relating them to the social and environmental conditions. This was an observational study of analytical character. Were used as the data source: the System of Information on Live Newborns and information of social and environmental conditions obtained from the database of the 2010 Demographic Census for the city of Botucatu. As results from the study, was identified a high cluster (Jardim Riviera e Jardim Santa Elisa) and a low one (Paraíso II e Jardim Altos do Paraíso), areas with large and small numbers of cases, respectively. No relationship of cases with environmental conditions has been identified. As social conditions, the analysis found an association between income and social risk. Lack of partner and maternal age less than 19 years were significant neonatal risk factors in municipality. It was concluded that Botucatu is homogeneous for environmental issues, there was no association between them and newborn risk. Income was the only factor capable of capturing any inequalities, indirectly influencing the risk rating of the neonate at birth. Proved necessary to develop actions that promote the inclusion of family planning in the context of life of young people, especially at the neighborhoods of the high cluster, where ...
Zanchim, Camila Cristina. "Identificação das áreas com maior risco de morbimortalidade neonatal a partir de geoprocessamento /." Botucatu, 2013. http://hdl.handle.net/11449/98420.
Повний текст джерелаCoorientador: Cassiano Victória
Banca: Maria Candida de Carvalho Furtado
Resumo: A vigilância da mortalidade infantil e fetal é uma das prioridades do Ministério da Saúde. Contribui para o cumprimento dos compromissos assumidos pelo Governo Brasileiro em defesa da criança, tais como o Objetivo de Desenvolvimento do Milênio, o Pacto pela Redução da Mortalidade Neonatal; o Pacto pela Vida e, mais recentemente, o Programa Mais Saúde e Rede Cegonha. O objetivo geral deste estudo foi identificar as áreas do município de Botucatu/SP, com maior concentração de recém-nascidos classificados como com risco de adoecer ou morrer, considerando-se o ano de 2010 e utilizando técnicas de geoprocessamento. Para análise de dados, buscou-se identificar as ocorrências por setor censitário, relacionandoas a condições sociais e ambientais. Trata-se de estudo observacional de caráter analítico. Foram utilizados como fonte de dados: o Sistema de Informações de Nascidos Vivos e informações sobre condições sociais e ambientais obtidas do banco de dados do Censo Demográfico 2010 para o município de Botucatu. Como resultados do estudo foram identificados um agrupamento alto (Jardim Riviera e Jardim Santa Elisa) e outro baixo (Jardim Paraíso II e Jardim Altos do Paraíso), áreas com grande e pequeno número de casos, respectivamente. Nenhuma relação dos casos com condições ambientais foi identificada. Quanto às condições sociais, as análises encontraram associação entre renda e risco social. Ausência de companheiro e idade materna inferior a 19 anos foram importantes fatores de risco neonatal no município. Concluiu-se que o município de Botucatu é homogêneo para questões ambientais, não havendo associação entre estas e o risco do recém-nascido. A renda foi o único fator capaz de captar eventuais desigualdades existentes, influenciando indiretamente na classificação de risco do neonato ao nascer. Mostrou-se necessário o desenvolvimento de ações que incentivem a ...
Abstract: Surveillance on child and fetal mortality is one of the priorities of the Ministry of Health. It contributes to the fulfillment of commitments taken by the Brazilian Government for children's defense, such as the Millennium's Development Objective; Agreement for Reduction of Neonatal Mortality; Agreement for Life and, more recently, the Mais Saúde and Rede Cegonha Programs. The goal of this study is to identify areas in the city of Botucatu/SP with a higher concentration of newborns classified as at risk for falling ill or dying by considering the year of 2010 and using geoprocessing techniques. For data analysis, was sought to identify occurrences per census tract, relating them to the social and environmental conditions. This was an observational study of analytical character. Were used as the data source: the System of Information on Live Newborns and information of social and environmental conditions obtained from the database of the 2010 Demographic Census for the city of Botucatu. As results from the study, was identified a high cluster (Jardim Riviera e Jardim Santa Elisa) and a low one (Paraíso II e Jardim Altos do Paraíso), areas with large and small numbers of cases, respectively. No relationship of cases with environmental conditions has been identified. As social conditions, the analysis found an association between income and social risk. Lack of partner and maternal age less than 19 years were significant neonatal risk factors in municipality. It was concluded that Botucatu is homogeneous for environmental issues, there was no association between them and newborn risk. Income was the only factor capable of capturing any inequalities, indirectly influencing the risk rating of the neonate at birth. Proved necessary to develop actions that promote the inclusion of family planning in the context of life of young people, especially at the neighborhoods of the high cluster, where ...
Mestre
Costa, Evaldo Lima da [UNESP]. "Fatores associados e desfechos perinatais em gestação na adolescência em uma amostra de gestantes do Distrito Federal." Universidade Estadual Paulista (UNESP), 2011. http://hdl.handle.net/11449/99210.
Повний текст джерелаFundação de Ensino e Pesquisa em Ciências da Saúde (FEPECS)
A análise da evolução e principais características dos nascimentos no Brasil no período de 2000 a 2007 evidencia que mulheres com idade de 15 a 19 anos, no momento do parto, respondem por 20% dos nascimentos no país. Estudos indicam que a gravidez na adolescência, etapa da vida de 10 a 19 anos, está associada a eventos adversos no recém- -nascido como baixo peso, prematuridade e comprometimento das condições de vitalidade ao nascimento. Dois objetivos foram definidos: 1.Revisar a ocorrência de partos prematuros e de baixo peso ao nascer com a gravidez em adolescentes e sua condição socioeconômica e cultural. Analisar os nascimentos, descrevendo-os segundo características da gestação, do parto e do recém-nascido. Dois trabalhos foram realizados para responder os objetivos. O primeiro compreende um artigo de revisão de um levantamento bibliográfico onde foram identificados textos que abordam assunto e o segundo um artigo original. Neste trabalho foram analisadas 24.800 declarações de nascidos vivos, correspondentes aos partos hospitalares ocorridos no Hospital Regional da Asa Sul (HRAS), no período de 1º de janeiro de 2006 a 31 de dezembro de 2009. As faixas etárias maternas foram estratificadas em: adolescente precoce, idade entre 10 a 14 anos; adolescente tardia, idade de 15 a 19 anos e adultas jovens, de 20 a 35 anos. Foi utilizando o programa estatístico SPSS versão 17.0 e aplicado o Qui-quadrado de Pearson com significância de 5 %. Rocha et al apuraram que a ocorrência de baixo peso logo após o nascimento no grupo de gestantes precoces foi muito maior (13,5%) em relação ao grupo de gestantes tardias (3,1%); identificaram no seu estudo que 91,3% das gestantes precoces possuíam somente o ensino fundamental, enquanto que as gestantes tardias representavam 55,5%. Ainda nessa pesquisa...
An analysis of the development and main characteristics of births in Brazil from 2000 to 2007 suggests that women aged 15 to 19 at childbearing represent 20% of births in this country. Studies have demonstrated that pregnancy among teenagers, a stage of life between the ages of 13 and 19, is associated with adverse birth outcomes such as low-birth weight, prematurity and compromised vitality conditions at birth. Two objectives were defined:To revise the incidence of preterm births and low-birth weight in teenage pregnant mothers and their socioeconomic and cultural condition. To analyse the births, describing them according to pregnancy, delivery and newborn infant characteristics. Two studies were carried out to meet the objectives. The first one is a review article based on reference materials in which article s related to the topic were identified, and the second one, the original article. In the present study, we analysed 24.8000 declarations of live births corresponding to hospital births at the Hospital Regional da Asa Sul (HRAS), from January 1, 2006, to December 31, 2009. The mother age groups were stratified in: precocious adolescent, aged between 10 to 14; late adolescent, between 15 to 19; and young adult, between 20 to 35. We used the statistical program SPSS version 17.0 and applied the Chi-square Pearson with 5% level of significance. Rocha et al concluded that the incidence of low-birth weight in the group of precocious pregnant adolescents was much higher (13.5%) if compared to the group of late pregnant adolescents (3.1%); it was also showed that 91.3% of precocious pregnant adolescents had just basic schooling while in the late pregnant adolescents, 55.5%. Still in this study it has been showed that 37.5% of precocious pregnant adolescents had poor prenatal care, having fewer than 07 visits... (Complete abstract click electronic access below)
Trevors, Tanya. "Neonatal morbidity among macrosomic infants in the James Bay Cree population of northern Quebec." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=33034.
Повний текст джерелаVerrall, Tanya Christine. "Preventing iron deficiency anemia : communication strategies to promote iron nutrition for at-risk infants in northern Quebec." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=85102.
Повний текст джерелаMass media (i.e., radio dialogues, key messages, print material, point-of-purchase grocery store display) and interpersonal (i.e., homemade baby food cooking activity) communication strategies were developed in collaboration with community members and implemented in partnership with an existing community program. Reach and exposure of the strategies were measured using a questionnaire administered to a post-intervention sample (n = 45). Sales of promoted iron-rich infant food were examined pre- and post-intervention period. A repeat cross-sectional design was used for the impact evaluation. Two groups of mothers with infants, aged 7-10 months at Time 1 (n = 32) and Time 2 (n = 22) were interviewed. Outcome variables were infants' total iron and complementary food iron intakes measured by two 24-hour recalls. Secular trends in infants' hemoglobin values and milk type consumption were examined in the study community and two comparison communities.
Multiple communication channels increased awareness of IDA and influenced self-reported use of iron-rich infant food. Iron-rich infant food sales increased from pre- to post-intervention (p < 0.05). Complementary food intake iron increased between Time 1 (3.2 +/- 0.8 mg) and Time 2 (4.4 +/- 1.1 mg) (p < 0.05). The proportion of infants with anemia (hemoglobin < 110 g/L) significantly decreased from the period before (37.2%) to during (14.3%) the intervention (p < 0.05). No significant difference was found for this variable within the comparison communities. The proportion of infants receiving iron-fortified formula in the study community did not differ between Time 1 and Time 2, but increased from Time 1 (55%) to Time 2 (73%) (p < 0.05) in the comparison communities, indicating an erosion of breastfeeding practice.
These results suggest the effectiveness of communication strategies to improve infant iron nutrition in a community with good access to iron-rich infant food. The potential for this strategy in other communities warrants further investigation.
Costa, Evaldo Lima da. "Fatores associados e desfechos perinatais em gestação na adolescência em uma amostra de gestantes do Distrito Federal /." Botucatu : [s.n.], 2011. http://hdl.handle.net/11449/99210.
Повний текст джерелаCoorientador: Maria Cristina Ferreira Sena
Banca: Olímpio Barbosa de Moraes Filho
Banca: Adriano Bueno Tavares
Resumo: A análise da evolução e principais características dos nascimentos no Brasil no período de 2000 a 2007 evidencia que mulheres com idade de 15 a 19 anos, no momento do parto, respondem por 20% dos nascimentos no país. Estudos indicam que a gravidez na adolescência, etapa da vida de 10 a 19 anos, está associada a eventos adversos no recém- -nascido como baixo peso, prematuridade e comprometimento das condições de vitalidade ao nascimento. Dois objetivos foram definidos: 1.Revisar a ocorrência de partos prematuros e de baixo peso ao nascer com a gravidez em adolescentes e sua condição socioeconômica e cultural. Analisar os nascimentos, descrevendo-os segundo características da gestação, do parto e do recém-nascido. Dois trabalhos foram realizados para responder os objetivos. O primeiro compreende um artigo de revisão de um levantamento bibliográfico onde foram identificados textos que abordam assunto e o segundo um artigo original. Neste trabalho foram analisadas 24.800 declarações de nascidos vivos, correspondentes aos partos hospitalares ocorridos no Hospital Regional da Asa Sul (HRAS), no período de 1º de janeiro de 2006 a 31 de dezembro de 2009. As faixas etárias maternas foram estratificadas em: adolescente precoce, idade entre 10 a 14 anos; adolescente tardia, idade de 15 a 19 anos e adultas jovens, de 20 a 35 anos. Foi utilizando o programa estatístico SPSS versão 17.0 e aplicado o Qui-quadrado de Pearson com significância de 5 %. Rocha et al apuraram que a ocorrência de baixo peso logo após o nascimento no grupo de gestantes precoces foi muito maior (13,5%) em relação ao grupo de gestantes tardias (3,1%); identificaram no seu estudo que 91,3% das gestantes precoces possuíam somente o ensino fundamental, enquanto que as gestantes tardias representavam 55,5%. Ainda nessa pesquisa... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: An analysis of the development and main characteristics of births in Brazil from 2000 to 2007 suggests that women aged 15 to 19 at childbearing represent 20% of births in this country. Studies have demonstrated that pregnancy among teenagers, a stage of life between the ages of 13 and 19, is associated with adverse birth outcomes such as low-birth weight, prematurity and compromised vitality conditions at birth. Two objectives were defined:To revise the incidence of preterm births and low-birth weight in teenage pregnant mothers and their socioeconomic and cultural condition. To analyse the births, describing them according to pregnancy, delivery and newborn infant characteristics. Two studies were carried out to meet the objectives. The first one is a review article based on reference materials in which article s related to the topic were identified, and the second one, the original article. In the present study, we analysed 24.8000 declarations of live births corresponding to hospital births at the Hospital Regional da Asa Sul (HRAS), from January 1, 2006, to December 31, 2009. The mother age groups were stratified in: precocious adolescent, aged between 10 to 14; late adolescent, between 15 to 19; and young adult, between 20 to 35. We used the statistical program SPSS version 17.0 and applied the Chi-square Pearson with 5% level of significance. Rocha et al concluded that the incidence of low-birth weight in the group of precocious pregnant adolescents was much higher (13.5%) if compared to the group of late pregnant adolescents (3.1%); it was also showed that 91.3% of precocious pregnant adolescents had just basic schooling while in the late pregnant adolescents, 55.5%. Still in this study it has been showed that 37.5% of precocious pregnant adolescents had poor prenatal care, having fewer than 07 visits... (Complete abstract click electronic access below)
Mestre
Ikeakanam, Ottilie Tangeni Omuwa. "Infant feeding practices in the prevention of mother to child transmission in Onandjokwe district hospital, Namibia." Thesis, Stellenbosch : Stellenbosch University, 2011. http://hdl.handle.net/10019.1/17794.
Повний текст джерелаENGLISH ABSTRACT: The impact of infant feeding practices in the prevention of mother-to-childtransmission of HIV raised concerns in the field of health services. Breast feeding adds an additional 15-30% risk of HIV transmission to the infant; therefore, mothers who are HIV-positive are in need of information regarding safe infant feeding. A descriptive design for this particular study was applied with a primary quantitative approach. A convenient sample of sixty (n=60) participants between the ages of 15 – 37 were taken from subjects that enrolled in the prevention of mother-to-child transmission (PMTCT) programme in Onandjokwe district. The sample formed 85% of the target population (N=71). A structured questionnaire with closed and openended questions was used and completed by the researcher. Ethical approval for the study was obtained from the Ethics Committee at the Faculty of Health Sciences, University of Stellenbosch. Permission to conduct the research was obtained from the Ministry of Health and Social Services, Namibia, and the Onandjokwe district Hospital. A pilot study was conducted that constituted 25% of the sample. Validity and reliability was insured by the pilot study and the consultation of an expert in HIV research and an expert in nursing research. The presentation of results was mostly descriptive in nature by using frequency tables and a pie chart. The results showed that all participants (n=60/100%) were offered HIV counselling and testing during antenatal care. Mothers who were HIV positive knew that there is a possibility that the baby might be infected through breast milk. Furthermore, the study found that 70% (n=42) of participants used breast feeding exclusively, 20% (n=12) used replacement feeding and 10% (n=6) used mixed feeding practices. It was concluded that pregnant women and mothers known to be HIV-infected should be informed of the infant feeding practice recommended by the national or subnational authority to improve HIV-free survival of HIV-exposed infants. This includes information about the risks and benefits of various infant feeding options based on local assessments and guidance in selecting the most suitable option for their own situation.
AFRIKAANSE OPSOMMING: Die invloed van voedingspraktyke vir babas by die voorkoming van moeder-na-kindoordrag van die menslike immuungebrekvirus (MIV) het kommer op die gebied van gesondheidsdienste laat ontstaan. Borsvoeding dra ’n addisionele 15–30% risiko van MIV-oordrag tot die baba by en daarom benodig moeders wat MIV-positief is inligting ten opsigte van veilige voeding van hulle babas. 'n Beskrywende ontwerp vir hierdie besondere studie is gebruik tesame met 'n primêr kwantitatiewe benadering. 'n Gerieflikheidsteekproef van sestig (n=60) deelnemers tussen die ouderdomme 15–37 jaar is gekies uit persone wat ingeskryf het vir die voorkoming van moeder-na-kind-oordrag (VMNKO) program in Onandjokwe-distrik. Die steekproef het 85% van die teikenpopulasie (N=71) uitgemaak. 'n Gestruktureerde vraelys met geslote en oop vrae is gebruik en deur die navorser voltooi. Etiese goedkeuring vir die studie is verkry van die Etiese Kommitee van die Fakulteit Gesondheidswetenskappe, Universiteit Stellenbosch. Toestemming om die navorsing te doen, is verkry van die Ministerie van Gesondheid en Maatskaplike Dienste, Namibië, en die Onandjokwe Distrikshospitaal. 'n Loodsstudie is onderneem wat 25% van die steekproef behels het. Geldigheid en betroubaarheid is verseker deur die loodsstudie en oorlegpleging met 'n kundige op die gebied van MIV-navorsing en 'n kundige in verpleegnavorsing. Die aanbieding van resultate was meestal deskriptief van aard deur van frekwensietabelle en 'n sektordiagram gebruik te maak. Die resultate het getoon dat MIV-berading en -toetsing gedurende voorgeboortesorg aan alle deelnemers (n=60/100%) aangebied is. Moeders wat MIV-positief is, het geweet dat daar 'n moontlikheid bestaan dat die baba moontlik deur moedersmelk geïnfekteer kan word. Verder het die studie bevind dat 70% (n=42) van deelnemers uitsluitlik borsvoeding gebruik, 20% (n=12) gebruik ’n vervanging vir moedersmelk en 10% (n=6) gebruik gemengde voedingspraktyke. Daar is tot die slotsom gekom dat swanger vroue en moeders van wie bekend is dat hulle MIV-geïnfekteer is, ingelig behoort te word oor die babavoedingspraktyk aanbeveel deur die nasionale of subnasionale owerheid vir die verbetering van MIVvrye oorlewing van babas wat aan die MIV blootgestel is. Dit sluit in inligting oor die risiko’s en voordele van verskeie babavoedingsopsies gebaseer op plaaslike assesserings en leiding ten opsigte van die kies van die geskikste opsie vir hulle eie situasie.
Camillo, Débora de Fátima. "Avaliação tecnológica e clínica de protetores nasais empregados na ventilação não invasiva de recém-nascidos." Universidade Tecnológica Federal do Paraná, 2016. http://repositorio.utfpr.edu.br/jspui/handle/1/2518.
Повний текст джерелаThe nasal injury resulting from the use of non-invasive ventilation (NIV) is an adverse event increasingly common in the newborn intensive care unit (NICU) and shows the short and long term consequences. This lesion can result both aesthetic and functional sequelae, limit the use of NIV in newborns who need this ventilatory support, cause discomfort and septicemia, may thereby increase the length of stay in NICU. This research aims to evaluate technological and clinically nasal protectors used with NIV of newborns admitted to the NICU. The methodology consisted primarily in raising the possible causes of nasal injury and assess the risk factors associated with its development. Then, it was conducted a randomized clinical trial to compare the effects of three kind of nasal protector and new and sterilized prongs on the severity of nasal lesions. And finally, it was performed the thermal and structural characterization of nasal protection after being aged with temperature and humidity inside the neonatal incubator. The main causes of injury were related to characteristics of the material, equipment problems, assistive, neonatal and professional factors. In this study, it was found as risk factors: gestational age, weight at birth, the total time stay in the NIV, the reuse of this support, the time of first use and reuse of NIV and the length of stay in the NICU. They were not observed significant differences in lesion severity when compared the three protectors studied, nor when used new and sterilized prongs. The materials analysis indicated that exposure to temperature and humidity changed the percentage of crystallinity and the roughness of the nasal protections studied.
Hurlimann, Thierry. "The duty to treat very defective neonates as "persons" : from the legal and moral personhood of very defective neonates to their best interests in medical treatment." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=80929.
Повний текст джерелаOppenheimer, Stephen James. "Iron deficiency and susceptibility to infection : a prospective study of the effects of iron deficiency and iron prophylaxis in infants in Papua New Guinea." Thesis, University of Oxford, 1987. http://ora.ox.ac.uk/objects/uuid:1891d054-1564-47f5-b2e0-b6da5f60e996.
Повний текст джерелаDavis, Annemarie, D. Labadarios, D. Marais, and M. F. Cotton. "Prevention of mother-to-child transmission programme : how "informed" is the literate mother's decision regarding infant feeding options in the Gert Sibande district, Mpumalanga province, South Africa." Thesis, Stellenbosch : University of Stellenbosch, 2005. http://hdl.handle.net/10019.1/4957.
Повний текст джерелаDigitized at 330 dpi color PDF format (OCR), using KODAK i 1220 PLUS scanner.
Thesis (MNutr (Interdisciplinary Health Sciences))--University of Stellenbosch, 2005.
ENGLISH ABSTRACT: "A comprehensive package of care for the Prevention of Mother- To-Child Transmission (PMTCT) of HIV" states that all mothers participating in the PMTCT Programme should receive education that will enable them to make informed decisions about infant feeding options. Rapid, same-day HIV testing and results that are available immediately, enable health care workers to be responsible for providing pre- and post-test counselling (which includes infant feeding options) on the same day. This could place a tremendous workload and time pressure on the health care workers. The aim of this study was to determine how "informed" is the literate mother's decision regarding infant feeding options, who participated in the PMTCT Programme, in the Gert Sibande District, Mpumalanga, South Africa. Method: Data was collected from health care workers and mothers on the PMTCT Programme at 23 PMTCT sites in the Gert Sibande District, with the help of 6 field workers and the PMTCT site manager at each PMTCT site, by means of once-off, self-administered questionnaires, which had been previously tested and validated. Results: Health care workers' attitude towards the PMTCT Programme was positive, although some (14%) indicated that what was expected of them was not achievable in their working environment. The most prominent change relating to the personal preferences of health care workers regarding infant feeding options for HIV-infected mothers, after attending the 5-day PMTCT course, was from formula-feeding to breast-feeding. Most (65%) indicated it was possible to stay neutral in a counselling session regardless of personal preference for infant feeding and 60% of those who could not stay neutral, still thought it was in the mother's best interest to be counselled by them. Most (98%) agreed mothers had the right to make informed decisions and 80% agreed mothers were able to make such a decision. Most (67%) health care workers indicated that not enough staff was stationed at PMTCT sites, only 53% used the feeding option cards when counselling mothers and indicated that more educational material was needed. Sixty one percent of the health care workers demonstrated the preparation of the formula to the mothers and allowed the mothers to demonstrate back to them. Between 49-82% and 37-56% of the health care workers knew the correct answers to knowledge questions relating to breastfeeding and formula-feeding, respectively. Not one health care worker, nor mother, knew all the steps in preparing a formula feed. Most (80%) mothers made decisions based on information provided to them by health care workers and only a small (13%) percentage were influenced by the community to practise a different feeding option than what they had chosen. Conclusions: The attitude, personal preferences, knowledge of and resources available to health care workers, influenced the decision made by mothers regarding infant feeding options and seeing that most mothers made their decision, based on information provided by health care workers, it is concluded that mothers can only make an informed decision about infant feeding options if they are advised appropriately by well trained, equipped and informed health care workers.
AFRIKAANSE OPSOMMING: "A comprehensive package of care for the Prevention of Mother-To-Child Transmission of HIV", vermeld dat moeders, wat deelneem aan die Voorkoming van Moeder-Tot-Kind Oordrag (VMTKO) progam, voorligting behoort te ontvang ten opsigte van voedingsopsies vir hul babas, sodat hulle in staat sal wees om 'n ingeligte keuse te maak. Gesondheidswerkers is verantwoordelik om voorligting voor en na die HIV toets te gee, wat die voedingsopsies vir babas insluit, op dieselfde dag. Dit kan 'n ontsaglike werkslading op die gesondheidswerkers plaas. Die doel van die studie was om te bepaal hoe "ingelig" is die geletterde moeder se keuse ten opsigte van voedingsopsies, wat deelneem aan die VMTKO program, in die Gert Sibande distrik, Mpumalanga, Suid-Afrika. Metode: Die data is ingesamel by 23 VMTKO-klinieke en -hospitale in die Gert Sibande distrik onder gesondheidswerkers en moeders op die VMTKO-program, met behulp van 6 veldwerkers en VMTKO-bestuurders, deur middel van eenmalige, selfvoltooide vraelyste, wat van tevore getoets en gevalideer was. Resultate: Die gesondheidswerkers se houding teenoor die VMTKO-program was positief, alhoewel 14% aangedui het dat wat van hulle verwag word nie prakties of moontlik is in hul werksomgewing nie. Die prominentste verandering rakende die persoonlike voorkeure van die gesonheidswerkers teenoor voedingsopsies vir HIV -geinfekteerde moeders, na die 5-dag VMTKO kursus, was van formulevoeding na borsvoeding. Meeste (65%) het aangedui dit is moontlik om neutraal te bly gedurende 'n voorligtingssessie, ten spyte van persoonlike voorkeure vir voedingsopsies en 60% van die wat nie neutraal kon bly nie, het steeds gedink dit is in die beste belang van die moeder om deur hulle voorgelig te word. Meeste (98%) het saamgestem dat dit die moeder se reg is om 'n ingeligte keuse te maak en 80% het saamgestem dat die moeder wel in staat is om so 'n besluit te neem. Meeste (67%) gesondheidswerkers het aangedui dat personeel tekorte bestaan by die VMTKO klinieke en hospitale. Slegs 53% gebruik die voedingsopsie kaarte gedurende 'n voorligtingsessie met die moeder en het aangedui dat meer voorligtingsmateriaal benodig word. Een en sestig persent van die gesondheidswerkers het die voorbereiding van die formulevoeding aan die moeders gedemonstreer en het moeders toegelaat om ook die demonstrasie te doen. Nege en veertig tot twee en tagtig persent en 37-56% van die gesondheidswerkers kon die korrekte antwoorde verskaf vir vrae oor borsvoeding en formulevoeding, afsonderlik. Nie een gesondheidswerker of moeder kon al die stappe vir die voorbereiding van die formulevoeding noem nie. Meeste (80%) moeders maak keuses gebaseer op inligting wat aan hulle verskaf word deur die gesondheidswerkers en slegs 'n klein persentasie (13%) word beinvloed deur familielede om die teenoorgestelde voedingsopsie te praktiseer as wat hulle gekies het. Gevolgtrekking: Die houding, persoonlike voorkeure, kennis van en hulpbronne beskikbaar aan die gesongheidswerkers, beinvloed die besluit wat moeders neem ten op sigte van voedingsopsies en aangesien die moeders hulle besluit baseer op inligting wat deur die gesondheidswerkers aan hulle gegee word, word die gevolgtrekking gemaak dat moeders slegs 'n ingeligte keuse aangaande voedingsopsies kan maak indien hulle voorligting ontvang deur goed opgeleide en ingeligte gesondheidswerkers.
La, Grange Heleen. "Respiratory pathogens in cases of Sudden Unexpected Death in Infancy (SUDI) at Tygerberg forensic pathology service mortuary." Thesis, Stellenbosch : Stellenbosch University, 2014. http://hdl.handle.net/10019.1/86628.
Повний текст джерелаENGLISH ABSTRACT: Background: Sudden infant death syndrome (SIDS) is considered the second most frequent cause of infant mortality worldwide. Research specifically pertaining to SIDS is limited in the South African setting. Identifiable causes for sudden infant death remain challenging despite full medico-legal investigations inclusive of autopsy, scene visit and ancillary studies. Viral infections could contribute to some sudden unexpected death in infancy (SUDI) cases, especially since a multitude of respiratory viruses have been detected from autopsy specimens. The specific contribution of viruses in the events preceding death, including the subsequent involvement of the immature immune response in infants, still warrants deciphering. Infancy is characterised by marked vulnerability to infections due to immaturities of their immune systems that may only resolve as infants grow older when these sudden deaths rarely still occur. In South Africa there is a lack of a standard protocol for investigations into the causes of SIDS, including the lack of standard guidelines as to which specimens should be taken, which viruses should be investigated and which laboratory assays should be utilised. Objectives: In this prospective descriptive study we aimed to investigate the prevalence of viruses in SUDI and SIDS cases at Tygerberg Forensic Pathology Service (FPS) Mortuary over a one year period. The primary aim was to explore possible respiratory viral infections in SUDI and SIDS cases and to determine the usefulness of molecular techniques to detect viruses from SUDI cases. To determine the significance of viruses, we assessed signs of infection from lung histology. The secondary objectives included collecting demographic data to investigate possible risk factors for SUDI and to look for possible similarities between viruses confirmed in living hospitalised infants at Tygerberg, during the study period compared to viruses detected from SUDI cases. Methods: Between May 2012 and May 2013 samples were collected from 148 SUDI cases presenting at Tygerberg FPS Mortuary. As part of the mandatory routine investigations into SUDI, shell vial culture (SVC) results were collected from lung and liver tissue specimens and bacterial culture results were collected from left and right lung and heart swabs at autopsy. To investigate the possibility of viruses implicated in some of the infant deaths we used the Seeplex® RV15 Ace detection multiplex polymerase chain reaction (PCR) assay to establish the frequency of 13 ribonucleic acid (RNA) respiratory viruses (influenza A and B, human parainfluenza 1-4, human coronavirus [OC43, 229E/NL63], human rhinovirus A, B and C, respiratory syncytial virus A and B, human enterovirus and human metapneumovirus) from RNA extracted from tracheal and lower left and right lung lobe swabs. Tissue from the lower left and right lung lobes were also assessed for histology signs of infection. Results: During our study we confirmed multiple known demographic risk factors for SIDS, such as the age peak around 1-3 months, the male predominance, bed-sharing, sleeping in the prone position, heavy wrapping in warm blankets, prenatal smoke exposure, and socio-economic factors. With the Seeplex® RV15 Ace detection assay between one and three viruses were detected in 59.5% (88/148) of cases. Of the 88 cases that had viruses detected, 75% (66/88) had one virus and 25% (22/88) had co-detections of two to three viruses. The most common viruses detected were HRV in 77% (68/88) of cases, RSV in 18% (16/88) of cases and HCoV in 14% (12/88) of cases. Many of the viruses we detected from our cases are included in the SVC test that forms part of the medico-legal laboratory investigation for all SUDI cases at Tygerberg FPS Mortuary. SVCs were positive in 9.5% (14/148) of all cases only. We showed that the SVC method is potentially missing most of the 13 respiratory viruses we investigated that could contribute to death in some of the SUDI cases. Conclusion: In some cases that had a Cause of Death Classification - SIDS, the PCR viruses detected cannot be ignored, especially when it is supported by histological evidence of infection. We thus propose that the use of PCR could alter a Cause of Death Classification from SIDS to Infection in some of these cases. Further research is needed to determine the significance of detecting viruses from SUDI cases wherein no significant histological evidence of infection was observed. This questions whether PCR may be too sensitive and is detecting past and latent viral infections that do not play any role in the cause of death. The histological picture also requires further characterisation to determine if it accurately predicts infections or lethal events and can truly support virology findings, especially in young infants whose immune systems are still maturing. Without determining the true prevalence of viruses in SUDI cases and the viral-specific immune response, the contribution of virus-specific infections to this syndrome will remain largely undetermined.
AFRIKAANSE OPSOMMING: Agtergrond: Wiegiedood (“SIDS/SUDI”) word beskou as die tweede mees algemene oorsaak van sterftes in kinders jonger as een jaar wêreldwyd. Toegewyde SIDS-spesifieke navorsing in die Suid-Afrikaanse samelewing is beperk. Dit bly steeds „n uitdaging om oorsake te probeer identifiseer vir hierdie onverwagte sterftes in kinders (SUDI) ten spyte van volledige medies-geregtelike ondersoeke, insluitende die lykskouing, ondersoek van die doodstoneel en aanvullende ondersoeke. Virusinfeksies kan aansienlik bydra tot sommige onverwagte sterftes in kinders, aangesien verskeie respiratoriese virusse alreeds aangetoon is in monsters verkry tydens outopsies. Die spesifieke rol wat virusse speel in die prosesse wat die dood voorafgaan, asook die bydraende rol van „n onder-ontwikkelde immuunrespons in babas, regverdig verdere ondersoek. Die eerste jaar van lewe word gekenmerk deur verhoogde vatbaarheid vir infeksies weens die ontwikkelende immuunstelsels soos wat babas ouer word, en die voorkoms van SUDI neem stelselmatig af met „n toename in ouderdom. In Suid-Afrika bestaan daar tans geen standaard protokol vir die ondersoek van wiegiedood nie en daar is ook nie standaard riglyne oor die tipe monsters wat geneem moet word, watter virusse ondersoek moet word en watter laboratorium toetse uitgevoer moet word nie. Doelstellings: In hierdie prospektiewe beskrywende studie is gepoog om die virusse wat in gevalle van wiegiedood of SUDI voorkom te ondersoek. Die studie is uitgevoer by die Tygerberg Geregtelike Patologie Dienste lykshuis oor 'n tydperk van een jaar. Molekulêre tegnieke om virusse aan te toon in hierdie gevalle is gebruik om spesifieke virusinfeksies te ondersoek. Die resultate is met histologiese tekens van infeksie in longweefsel gekorreleer. Demografiese data is verder versamel om moontlike risikofaktore vir wiegiedood te ondersoek. Dit is verder vergelyk met virusse wat met dieselfde diagnostiese tegnieke in babas geïdentifiseer is wat tydens die studieperiode in Tygerberg Hospitaal opgeneem was met lugweginfeksies. Metodes: Monsters van 148 SUDI gevalle wat by die Tygerberg lykshuis opgeneem is, is versamel tussen Mei 2012 en Mei 2013. As deel van die roetine ondersoeke in SUDI gevalle, was selkultuur resultate verkry van long en lewer weefsel, asook bakteriële kulture van deppers wat van beide longe en hart geneem was tydens die lykskouings. „n Seeplex® RV15 Ace polimerase kettingreaksie (PKR) toets is gebruik om die teenwoordigheid van virusse te ondersoek wat moontlik by die babasterftes betrokke kon wees. Trageale- en longdeppers wat tydens die lykskouings versamel was, was getoets vir 13 ribonukleïensure (RNS) respiratoriese virusse (influenza A and B, human parainfluenza 1-4, human coronavirus [OC43, 229E/NL63], human rhinovirus A, B and C, respiratory syncytial virus A and B, human enterovirus and human metapneumovirus). Resultate: Ons studie het verskeie bekende demografiese risikofaktore vir SUDI bevestig, byvoorbeeld „n ouderdomspiek tussen een en drie maande ouderdom, manlike predominansie, deel van „n bed met ander persone, slaap posisie op die maag, styf toedraai in warm komberse, blootstelling aan sigaretrook voor geboorte en sosio-ekonomiese faktore. Die Seeplex® RV15 Ace toets het tussen een en drie virusse geïdentifiseer in 59.5% (88/148) van die gevalle. Uit die 88 gevalle waarin virusse opgespoor was, was selgs een virus in 75% (66/88) van gevalle gevind en twee en drie virusse in 25% (22/88). Die mees algemene virusse was HRV in 77% (68/88) van gevalle, RSV in 18% (16/88) van gevalle en HCoV in 14% (12/88) van gevalle. Baie van die virusse wat tydens hierdie studie ondersoek was, was ingesluit in die roetine selkultuur toets wat deel vorm van die standaard medies-geregtelike laboratoriumondersoeke in alle SUDI gevalle by die Tygerberg lykshuis, alhoewel die selkulture positief was in slegs 9.5% (14/148) van gevalle. Ons het gevind dat baie respiratoriese virusse potensieel gemisdiagnoseer word wat „n rol kon speel in of bydra tot die dood van sommige SUDI gevalle. Gevolgtrekking: In sommige gevalle waarin SIDS geklassifiseer is as die oorsaak van dood, kan die virusse wat met PKR toetse opgespoor is nie geïgnoreer word nie, veral waar die bevinding ondersteun word deur histologiese bewyse van infeksie. Ons stel dus voor dat die gebruik van PKR toetse die oorsaak van dood klassifikasie kan verander van SIDS na Infeksie in sommige van hierdie gevalle. Verdere navorsing is nodig om die waarde van gelyktydige opsporing van virusse in SUDI gevalle te bepaal wanneer daar geen noemenswaardige histologiese bewyse van infeksie gevind word nie. Dit bevraagteken of die PKR toets dalk te sensitief is en gevolglik vorige en latente virusinfeksies identifiseer wat nie noodwendig 'n rol in die oorsaak van dood speel nie. Die diagnostiese en kliniese waarde van die histologiese beeld in terme van die rol van virusinfeksies as bydraende oorsaak van dood moet verder ondersoek word, veral in jong kinders wie se immuunstelsels nog nie volledig ontwikkel is nie. Indien die werklike voorkoms van virusse in SUDI gevalle en die virus-spesifieke immuunrespons nie bepaal word nie, sal die rol van virus-spesifieke infeksies in hierdie sindroom grootliks onbekend bly.
Harry Crossley Foundation
Poliomyelitis Research Foundation (PRF)
National Health Laboratory Services Research Trust
Madrid, Castillo María Dolores. "Understanding different opportunities to prevent severe disease and reduce mortality in African infants and children: From vertical transmission prevention to enhanced diagnosis of life-threatening conditions of childhood = Oportunidades para prevenir enfermedades graves y reducir la mortalidad en lactantes y niños africanos. Prevención de la transmisión vertical y mejora del diagnóstico de enfermedades que amenazan la vida de los niños." Doctoral thesis, Universitat de Barcelona, 2018. http://hdl.handle.net/10803/523483.
Повний текст джерелаLa mortalidad de lactantes y niños ha jugado un papel crucial en los patrones de transición de la salud y es considerado un buen indicador de desarrollo y modernización demográfica a lo largo del tiempo. El establecimiento de los Objetivos de Desarrollo del Milenio (MDGs) supuso una importante inyección de fondos y recursos para la mejora de la salud y un compromiso nacional e internacional con la salud infantil, que condujo a un progreso sin precedentes en la reducción de la mortalidad infantil en todo el mundo. En términos de infecciones neonatales, la sepsis neonatal y la meningitis son bien conocidas causas de muerte y enfermedades que pueden producir secuelas graves tanto en los bebés prematuros y como aquello a término en países industrializados. Sin embargo, la información sobre estas enfermedades y su impacto en los países empobrecidos del África subsahariana es más limitada. Otras enfermedades infecciosas también consideradas como contribuyentes importantes a la morbi-mortalidad neonatal, del lactante e incluso de niños más mayores son las infecciones englobadas en el síndrome TORCH. La pandemia del VIH y el brote del virus del Zika han suscitado gran preocupación en todo el mundo y han destacado la importancia de otros patógenos que afectan a los niños incluyendo virus, parásitos y hongos. La detección de algunas de estas enfermedades, como la sífilis o el VIH, se ofrece de forma rutinaria a las mujeres atendidas en las consultas prenatales (ANC) de países empobrecidos. Sin embargo, no ocurre lo mismo con la detección de otros posibles patógenos potencialmente transmisibles al feto durante el embarazo y parto, como citomegalovirus (CMV), rubéola, toxoplasma, enterovirus (EV), parvovirus B19 (B19V), virus del herpes simple (HSV) o hepatitis B (HBV), entre otros. La infección congénita por CMV (cCMV) es la más frecuente y la principal causa de sordera en los países desarrollados. Sin embargo, como sucede con la mayoría de las infecciones congénitas, permanece olvidada en entornos con recursos limitados, y se desconoce en gran parte su carga real y su impacto. En muchos países de renta media o baja, al menos la mitad de las muertes de niños se producen en casa, a menudo sin haber sido visitados por un clínico. Sin embargo, en algunos casos, los niños mueren en casa justo después de haber sido atendidos en un centro sanitario. La mortalidad hospitalaria es un contribuyente bien conocido de la mortalidad infantil y se han desarrollado e implementado con éxito guías e intervenciones para reducirla. Aunque la mortalidad posterior al alta hospitalaria (PDM) puede ser tan alta como la mortalidad hospitalaria en entornos con recursos limitados, es un fenómeno olvidado y poco estudiado. De hecho no se han desarrollado guías, recomendaciones o estrategias adicionales para abordar los días inmediatamente posteriores a alta hospitalaria, el cual es un período crítico para la supervivencia infantil. La fragilidad de los sistemas de salud en LIC, los altos costos inasequibles para atender enfermedades agudas y la falta generalizada de conciencia sobre la carga y las implicaciones del PDM por parte de los trabajadores de salud y los responsables políticos explican en parte que la mortalidad durante el periodo inmediato al alta hospitalaria permanezca relegada al olvido. Para alcanzar el nuevo objetivo de mortalidad infantil establecido por los Objetivos de Desarrollo Sostenible (SDGs) para 2030, es necesario mejorar el conocimiento en enfermedades graves en aquellos países con mayor morbi-mortalidad y desarrollar e implementar intervenciones para abordar las enfermedades que causan el mayor número de muertes entre los niños menores de 5 años. Esta tesis pretende abordar cuestiones relacionadas con las enfermedades graves que causan la mayoría de las muertes en lactantes y niños menores de cinco años y para las cuales no se han implementado intervenciones específicas en Manhiça, un área semirural en el sur de Mozambique.
Smith, Elaine. "An exploration of emerging problems for infant feeding options : some obstacles for the rapid expansion of the HIV mother-to-child transmission prevention programme : the KwaZulu-Natal experience." Thesis, 2003. http://hdl.handle.net/10413/4363.
Повний текст джерелаRamaboea, Moyahabo Joyce. "The factors contributing to high neonatal morbidity and mortality in Limpopo Province." Diss., 2014. http://hdl.handle.net/10500/18830.
Повний текст джерелаHealth Studies
M.A. (Health Studies)
Dlamini, Phumzile Lucia. "Knowledge, attitudes and practices associated with PMTCT among breastfeeding mothers living with HIV in a King Sobhuza II public health unit, Swaziland." Diss., 2015. http://hdl.handle.net/10500/19240.
Повний текст джерелаThe purpose of the study was to assess knowledge, explore attitudes and determine practices of breastfeeding mothers living with HIV regarding post-natal PMTCT interventions and services. The study was quantitative and descriptive in nature, utilising a retrospective cohort design. The study sample included breastfeeding mothers living with HIV, who attended the King Sobhuza II public health unit in the Manzini region of Swaziland. A written questionnaire was administered to a non-random sample of 90 consecutively selected mothers living with HIV attending the above-cited public health unit for post-natal health purposes. The overall study results revealed that the majority of breastfeeding mothers living with HIV in the afore-mentioned region (77.8%) presented high levels of knowledge on PMTCT, and 90% demonstrated a positive attitude; while a further 90% also demonstrated positive behaviour towards PMTCT. However, stigma and discrimination among family members, non-disclosure of HIV status to sexual partners; as well as poverty and fear of future drug-resistance are the cause of non-adherence to ARV prophylaxis. Furthermore, inconsistent condom use, mixed-feeding methods and wet-nursing also emerged as other contributing factors to the increase of post-natal mother-to-child transmission of HIV among breastfeeding mothers living with HIV.
Health Studies
M.A. (Nursing Science)
Moyo, Idah. "Experiences of HIV positive women who utilised the PMTCT programme in one of the central hospitals in Bulawayo, Zimbabwe." Thesis, 2016. http://hdl.handle.net/10500/21007.
Повний текст джерелаThis qualitative descriptive phenomenological study explored the experiences of HIV positive women utilising PMTCT services at a central hospital in Zimbabwe. Data was collected using in-depth interviews of fifteen participants. The interviews were audio recorded and transcribed verbatim. Using the Interpretive Phenomenological Analysis framework for data analysis, two super-ordinate themes emerged, namely resources for provision of PMTCT services and approaches and nature of PMTCT care. The study revealed challenges experienced by HIV positive women emanating from material, financial and human resource related constraints in the PMTCT setting. The resource challenges negatively affected access and utilisation of PMTCT services. A practice model, whose purpose is to enhance the quality and utilisation of PMTCT services, was developed and described. The model was evaluated using Chin and Krammer (2011) criteria plus a modified form of the Delphi technique. These findings have implications for effective PMTCT service provision. The key lessons learnt for programmatic improvement were that in order to provide quality and accessible PMTCT services the health care system will need to be well resourced. There is need to strengthen the health care system in line with HIV related programmatic changes.
Health Studies
D. L.itt. et Phil. (Health Studies)
"Necrotizing enterocolitis versus spontaneous intestinal perforation in high risk neonates: comparative investigations of plasma profiles of immunoregulatory proteins and specific expressions in intestinal tissues." 2011. http://library.cuhk.edu.hk/record=b5894836.
Повний текст джерелаThesis (M.Phil.)--Chinese University of Hong Kong, 2011.
Includes bibliographical references (leaves 179-204).
Abstracts in English and Chinese.
Abstract --- p.i
中文摘要 --- p.v
Acknowledgement --- p.viii
List of Abbreviations and Symbols x --- p.vi
List of Tables --- p.xx
List of Figures --- p.xxi
Chapter CHAPTER ONE --- Introduction --- p.1
Chapter 1.1 --- General Overview --- p.1
Chapter 1.2 --- Necrotizing Enterocolitis (NEC) --- p.3
Chapter 1.2.1 --- Epidemiology of NEC --- p.3
Chapter 1.2.2 --- "Clinical Presentation, Diagnosis and Management of NEC" --- p.5
Chapter 1.2.3 --- Pathophysiology of NEC --- p.9
Chapter 1.2.3.1 --- Prematurity --- p.9
Chapter 1.2.3.2 --- Bacterial Colonization --- p.12
Chapter 1.2.3.3 --- Enteral Feeding --- p.15
Chapter 1.2.3.4 --- Hypoxia and Ischemia --- p.16
Chapter 1.2.3.5 --- Genetic Polymorphism --- p.17
Chapter 1.2.3.6 --- Inflammatory Mediators --- p.20
Chapter 1.3 --- Spontaneous Intestinal Perforation (SIP) --- p.24
Chapter 1.3.1 --- Epidemiology of SIP --- p.24
Chapter 1.3.2 --- "Clinical Presentation, Diagnosis and Management of SIP" --- p.26
Chapter 1.3.3 --- Risk Factors of SIP --- p.28
Chapter 1.3.3.1 --- Prematurity --- p.29
Chapter 1.3.3.2 --- Use of Drugs --- p.30
Chapter 1.4 --- Comparison between NEC and SIP --- p.32
Chapter 1.5 --- Role of Cytokines in Pathogenesis of NEC and SIP --- p.38
Chapter 1.6 --- Immunoregulatory Molecules of Interest in This Study --- p.46
Chapter 1.6.1 --- Angiopoietin-2 (Ang-2) --- p.46
Chapter 1.6.2 --- v-erb-b2 Erythroblastic Leukemia Viral Oncogene Homolog 2 (avian) (ErbB3) --- p.48
Chapter 1.6.3 --- Type II Interleukin-1 Receptor (IL-1RII) --- p.52
Chapter 1.6.4 --- Urokinase Plasminogen Activator Receptor (uPAR) --- p.54
Chapter CHAPTER TWO --- Objectives --- p.57
Chapter CHAPTER THREE --- Materials and Methodology --- p.58
Chapter 3.1 --- Overview of the Experimental Procedures --- p.58
Chapter 3.1.1 --- Investigation on the Profile of Circulatory Immunoregulatory Proteins in Plasma of NEC and SIP High Risk Neonates --- p.58
Chapter 3.1.2 --- Investigation on the mRNA Expression Level of Targeted Immunoregulatory Molecules on Resected Intestinal Tissues in NEC and SIP Neonates --- p.58
Chapter 3.1.3 --- Investigation on the mRNA and Protein Expression Levels of Targeted Immunoregulatory Molecules in Human Intestinal Cell Lines --- p.60
Chapter 3.2 --- Reagents and Lab-wares with Their Sources --- p.61
Chapter 3.3 --- Study Population --- p.63
Chapter 3.4 --- Collection of Neonatal Whole Blood Samples --- p.65
Chapter 3.5 --- Cytokine Antibody Array Analyses --- p.67
Chapter 3.6 --- Enzyme-linked Immunosorbant Assays (ELISA) --- p.69
Chapter 3.6.1 --- Angiopoietin-2 --- p.69
Chapter 3.6.2 --- sErbB3 --- p.71
Chapter 3.6.3 --- sIL-lRII --- p.72
Chapter 3.6.4 --- suPAR --- p.74
Chapter 3.7 --- Collection of Neonatal Resected Intestinal Tissues --- p.76
Chapter 3.8 --- Resected Intestinal Tissue RNA Isolation --- p.78
Chapter 3.9 --- Purity Assessment of the Purified Tissue RNA Samples --- p.80
Chapter 3.10 --- Integrity Assessment of the Purified Tissue RNA Samples --- p.81
Chapter 3.11 --- In vitro Stimulation of Human Enterocytes by Lipopolysaccharides (LPS) and/or Platelet Activating Factor (PAF) --- p.84
Chapter 3.12 --- mRNA Expression Level Assessment of Selected Target Genes in Resected Intestinal Tissues and Human Intestinal Cell Lines --- p.86
Chapter 3.12.1 --- Synthesis of First Strand cDNA --- p.86
Chapter 3.12.2 --- Quantitative Polymerase Chain Reaction (qPCR) --- p.87
Chapter 3.13 --- Statistical Analysis --- p.89
Chapter CHAPTER FOUR --- Screening of Immunoregulatory Target Protein Molecules in Plasma of NEC and SIP Patients by Cytokine Array Analyses --- p.104
Chapter 4.1 --- Results --- p.104
Chapter 4.1.1 --- Screening of Detectable Immunoregulatory Target Molecules --- p.104
Chapter 4.1.2 --- Selection of Target Molecules Based on the Fold Change in NEC or SIP Compared with Control Samples --- p.105
Chapter 4.1.2.1 --- Similar Regulation of Target Molecules in Both NEC and SIP patients --- p.105
Chapter 4.1.2.2 --- Differential regulation of Target Molecules in NEC and SIP Patients --- p.106
Chapter 4.1.2.3 --- "Relative Normalized Expressions of Selected Circulatory Immunoregulatory Protein Molecules in NEC, SIP and Control Neonates" --- p.108
Chapter 4.1.2.3.1 --- Anti-inflammation --- p.108
Chapter 4.1.2.3.2 --- Pro-inflammation --- p.109
Chapter 4.1.2.3.3 --- Cell Growth --- p.110
Chapter 4.1.2.3.4 --- Wound Healing --- p.110
Chapter 4.1.2.3.5 --- Angiogenesis --- p.111
Chapter 4.1.2.3.6 --- "Anti-apoptosis, Cell Adhesion and Extracellular Matrix Organization" --- p.112
Chapter 4.1.3 --- Further Selection of Novel Target Molecules Based on Statistical Significance and Fold Change of NEC versus SIP --- p.113
Chapter 4.2 --- Discussion --- p.115
Chapter CHAPTER FIVE --- Validation of Target Proteins in Plasma of NEC and SIP Patients by Enzyme-linked Immunosorbant Assay --- p.132
Chapter 5.1 --- Results --- p.133
Chapter 5.1.1 --- Demographic Data of the Study Group --- p.133
Chapter 5.1.2 --- "Comparison of Plasma Levels of Target Proteins between NEC, SIP and Respective Controls" --- p.134
Chapter 5.1.3 --- Longitudinal Study of the Pre- and Post-operative Target Proteins Levels in Plasma --- p.136
Chapter 5.2 --- Discussion --- p.138
Chapter CHAPTER SIX --- Investigation on mRNA Expression Levels of Target Immunoregulatory Protein Molecules in Intestinal Tissue and Intestinal Cell Lines --- p.151
Chapter 6.1 --- Results --- p.152
Chapter 6.1.1 --- mRNA Expression Levels of Target Molecules in the Diseased Margin of Resected Intestinal Tissues of NEC and SIP patients --- p.152
Chapter 6.1.2 --- mRNA Expression Levels of Target Molecules in the Macroscopically Normal and Diseased Margin of Resected Intestinal Tissues of NEC and SIP patients --- p.154
Chapter 6.1.3 --- mRNA Expression Levels of Target Molecules in Human Intestinal Cell Lines upon LPS and PAF Challenge --- p.156
Chapter 6.1.3.1 --- FHs-74 Int Cell Line --- p.156
Chapter 6.1.3.2 --- Caco-2 Cell Line --- p.157
Chapter 6.2 --- Discussion --- p.158
Chapter CHAPTER SEVEN --- General Discussion --- p.171
Chapter 7.1 --- Overall Findings --- p.171
Chapter 7.2 --- Limitations of Study --- p.174
Chapter 7.3 --- Future Investigations --- p.177
References --- p.179
Khorshed, Mahmuda. "Preventable and treatable causes of infant death : examining neonatal and post neonatal mortality in rural Bangladesh." Master's thesis, 2010. http://hdl.handle.net/1885/150276.
Повний текст джерелаMulonda, Seani Adrinah. "Competence of midwives regarding prevention of low Apgar score among neonates." Diss., 2010. http://hdl.handle.net/11602/1016.
Повний текст джерела"The interaction between human leucocyte antigen-G and natural killer cells at the placental interface in HIV-1 infected pregnant women and the significance, if any, to in utero transmission." Thesis, 2007. http://hdl.handle.net/10413/2989.
Повний текст джерелаThesis (Ph.D.)-University of KwaZulu-Natal, Durban, 2007.
Guta, Yonas Regassa. "Post-mortem lessons : community-based model for preventing maternal mortality and newborn death in Ethiopia." Thesis, 2016. http://hdl.handle.net/10500/21911.
Повний текст джерелаHealth Studies
D. Litt. et Phil. (Health Studies)
Mashego, M. P. A. "Survival of very low birth and extreme low birth weight infants at Mankweng Neonatal Care Unit." Thesis, 2019. http://hdl.handle.net/10386/2930.
Повний текст джерелаObjectives To determine the prevalence and survival rate; and to assess the maternal risk factors as well as complications of prematurity, associated with the mortality of very low and extremely low birth weight infants in the Neonatal Intensive Care Unit (NICU) of Mankweng Hospital. Materials and Methods A retrospective descriptive study was conducted at the NICU of Mankweng Hospital for a 7-month period from 1st January to 31st July 2015. The patient medical records and the Perinatal Problem Identification Programme (PPIP) data were used for the study. Results Prevalence of prematurity was 23%, Infants weighing between 500g-1499g represented 6.3% of the total live births and 25% of the admissions to the NICU; of which 4.9% were classified as extremely low birth weight (ELBW). Overall 77% of the study population survived until discharge. From the medical records, the survival to discharge of infants with weight 500g - 999g was 52%; and 84% for those with weight 1000g-1499g. Multivariable analysis found that improved survival was associated with an increase in gestational age (p <0.001), as well as birth weight (p <0.001) and prolonged length of stay. Variables associated with poor survival were spontaneous preterm labour (p = 0.031), low Apgar score at 1 and 5 minutes (p <0.001), sepsis (p = 0.001), respiratory distress syndrome (p <0.001), pulmonary hemorrhage (p <0.001), hypothermia (P = 0.005), resuscitation at birth (p = 0.002) and necrotising enterocolitis (p =0.044). Antenatal steroids were not associated with survival (p =0.111), however this was not documented in 53%(134/252) of the records, so the non-significance to outcome in this study may not be a true reflection. The use of NCPAP or SiPAP only was associated with improved survival of up to 69% and high mortality rates were recorded in babies who required invasive ventilator support. Multi-organ immaturity was found to be the most common cause of death, followed by sepsis. Conclusion: The prevalence and survival rates of very low and extremely low birth weight, found in this study are comparable to those found in other tertiary hospitals in South Africa. The survival rate of ELBW babies is low and must be improved. Reliable data and further research should address effective steps to prevent preterm labour, extreme prematurity and hypothermia. The documentation and provision of antenatal steroids is encouraged. KEY CONCEPTS: Prematurity, Extremely low and Very low birth weight, Risk factors, Prevalence, Survival, Neonatal mortality rate.
"The impact of pneumonia in human immunodeficiency virus (HIV-1) infected pregnant women on perinatal and early infant mortality." Thesis, 2007. http://hdl.handle.net/10413/2541.
Повний текст джерелаThesis (M.Med.Sc.)-University of KwaZulu-Natal, Durban, 2007.
Khumalo, Gugulethu Eve. "Evaluation of knowledge and of effects of haemolytic disease of the newborn amongst postnatal women in the public hospitals of the Umgungundlovu district." Thesis, 2014. http://hdl.handle.net/10321/1051.
Повний текст джерелаThe purpose of the study was to evaluate knowledge and effects of Haemolytic Disease of the Newborn (HDN) in postnatal women from the Umgungundlovu District. Although the prevalence of HDN has declined because of prophylaxis from 45 cases per 10,000 births to 10.2 cases per 10,000 births but it is still a cause of infant and neonatal morbidity and mortality. The effects of the disease range from jaundice, kernicterus and in severe cases death. Methodology : An interviewer-administered questionnaire was used to obtain information about the knowledge and effects of HDN amongst postnatal women. The incidence rate was calculated using the number of cases that were found divided by the total number of deliveries during the study period. A total of 300 women were interviewed. SPSS version 19.0 was used to analyse data. Findings : Fifteen (15) of the 300 women had babies with confirmed HDN and only four of the 15 (26%) women had knowledge of HDN. Two hundred and eighty five women had babies with jaundice but were not affected by HDN and, of these women, 12 (4.2%) of them knew what HDN was. Overall, only 16 (5.3%) knew what HDN was. All 15 women who had babies with HDN indicated financial and emotional effects because of HDN. The total incidence was 0.09% for the first 12 months of the study period. Conclusion : Postnatal women with jaundiced babies lack knowledge of HDN and HDN has financial and emotional effects on these women. Although the incidence rate of HDN was found to be even smaller than previously reported, it still exists and threatens the lives of infants and neonates.
Bolukaoto, Yenga John. "Incidence and mechanism of antibiotic resistance of Streptococcus Agalactiae isolates from pregnant women and their babies at Dr George Mukhari Academic Hospital, Pretoria." Diss., 2014. http://hdl.handle.net/10500/14402.
Повний текст джерелаHealth Studies
M.Sc. (Life Sciences (Microbiology))
Nyathi, Emmanuel Mzwakhe. "Evaluation of immunization coverage among 0 to 24 month old children in Dzimauli Village, Vhembe District, South South." Diss., 2015. http://hdl.handle.net/11602/294.
Повний текст джерелаMonyama, Maropeng Charles. "Epidemiology and multilocus sequence typing of group B streptococcus colonising pregnant women and their neonates at Dr George Mukhari Academic Hospital, Pretoria." Diss., 2013. http://hdl.handle.net/10500/18309.
Повний текст джерелаLife & Consumer Sciences
Life Sciences
M.Sc. (Life Sciences)
Plaatjie, Bulelwa. "The impact of HIV and AIDS on planned parenthood in the area of Mthatha." Diss., 2009. http://hdl.handle.net/10500/3092.
Повний текст джерела