Дисертації з теми "Neuropathology"
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Spillantini, Maria Grazia. "Molecular neuropathology of Alzheimer's disease." Thesis, University of Cambridge, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.282037.
Повний текст джерелаHuseby, Carol. "Molecular Neuropathology in Alzheimer's Disease." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1543314678552794.
Повний текст джерелаBetts, Joanne. "The molecular neuropathology of mitochondrial disease." Thesis, University of Newcastle Upon Tyne, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.421187.
Повний текст джерелаTofaris, George Kynacov. "Molecular neuropathology of Lewy body disorders." Thesis, University of Cambridge, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.619824.
Повний текст джерелаDavis, Brittany. "Modelling the neuropathology of Ehmt1 haploinsufficiency." Thesis, Cardiff University, 2014. http://orca.cf.ac.uk/73068/.
Повний текст джерелаTabata, Rena Christina. "Neuropathology induced by sterol glucosides in mice." Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/24178.
Повний текст джерелаNagy, Zsuzsanna. "Aspects of the neuropathology of Alzheimer's disease." Thesis, University of Oxford, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.240537.
Повний текст джерелаBleshoy, Hans. "Neuropathology and sensitivity in the keratoconic cornea." Thesis, City University London, 1990. http://openaccess.city.ac.uk/7670/.
Повний текст джерелаPitts, Georgia Eloise Rollo. "Neuropathology and cognitive dysfunction after early hypoglycaemia." Thesis, University College London (University of London), 2017. http://discovery.ucl.ac.uk/10025822/.
Повний текст джерелаHenkes, Greta. "Neuropathologie primärer und sekundärer Mitochondriopathien im Rahmen entzündlicher Muskelerkrankungen." Doctoral thesis, Universitätsbibliothek Leipzig, 2011. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-71313.
Повний текст джерелаQuerol, Vilaseca Marta. "Novel digital neuropathology methods applied to neurodegenerative diseases." Doctoral thesis, Universitat Autònoma de Barcelona, 2020. http://hdl.handle.net/10803/671999.
Повний текст джерелаCada tres segundos alguien en el mundo desarrolla demencia. Las enfermedades neurodegenerativas, con la enfermedad de Alzheimer (EA), enfermedad de Parkinson y la demencia frontotemporal como las formas más prevalentes, son un grupo de desórdenes que afectan a millones de personas alrededor del mundo. La neuropatología de muestras post-mortem humanas aún es necesaria para esclarecer los mecanismos subyacentes alterados en las enfermedades neurodegenerativas. En esta tesis hemos combinado immunoensayos clásicos, técnicas de microscopía óptica y herramientas computacionales automatizadas para investigar la neuroinflamación y la acumulación anormal de proteínas en las enfermedades neurodegenerativas. En particular, hemos investigado alteraciones de los astrocitos y células gliales en la EA y otras taupatías. Hemos aprovechado las técnicas de super-resolución emergentes y hemos aplicado y optimizado el array tomography (AT) combinándolo con stimulated emission depletion microscopy (STED) para estudiar las placas de amiloide humanas a nivel nanométrico. Finalmente, hemos aplicado métodos digitales y AT para analizar cuantitativamente los cambios cerebrales en un paciente tratado con un inhibidor de BACE-1. Estos tres trabajos ilustran cómo las herramientas digitales pueden integrarse con los métodos neuropatológicos clásicos para la investigación de la EA y otras enfermedades neurodegenerativas.
Every 3 seconds someone in the world develops dementia. Neurodegenerative diseases (NDDs) with Alzheimer's disease (AD), Parkinson's disease (PD) and frontotemporal dementia (FTD) as the most prevalent forms are a group of disorders affecting millions of people worldwide. Neuropathology of post-mortem human samples is still needed to elucidate the underlying altered mechanisms of NDDs. In this thesis we combined classical immunoassays, light microscopy techniques and automated computational tools in order to investigate neuroinflammation and abnormal protein accumulation in NDDs. In particular, we investigated astrocytic and glial abnormalities in AD and other tauopathies. We took advantage of emerging super-resolution techniques and applied and optimized array tomography (AT) combined with stimulated emission depletion microscopy (STED) to study human amyloid plaques at a nanoscale level. Finally, we applied digital methods and AT to quantitative analyse the brain changes in a patient treated with a BACE-1 inhibitor. These three works illustrate how digital tools can be integrated with classical neuropathological methods in the investigation of AD and other NDDs.
Universitat Autònoma de Barcelona. Programa de Doctorat en Neurociències
Moore, David Joseph. "Regional neuropathology and cognitive abilities in HIV infection /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2003. http://wwwlib.umi.com/cr/ucsd/fullcit?p3083453.
Повний текст джерелаRahim, Rani Sadia. "Neuropathology in a Mouse Model of Zellweger Syndrome." Thesis, Griffith University, 2017. http://hdl.handle.net/10072/367161.
Повний текст джерелаThesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Natural Sciences
Science, Environment, Engineering and Technology
Full Text
Highley, J. Robin. "The asymmetry, interhemispheric connectivity, and gyral structure of the brain in schizophrenia : a post mortem study." Thesis, University of Oxford, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.244561.
Повний текст джерелаCotter, David Richard. "Abnormal brain development in schizophrenia : an investigation of potental mechanisms." Thesis, King's College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299927.
Повний текст джерелаArotcarena, Marie-Laure. "Approches multifactorielles et translationnelles dans la modélisation des synucléinopathies : implications mécanistiques et thérapeutiques." Thesis, Bordeaux, 2019. http://www.theses.fr/2019BORD0164/document.
Повний текст джерелаMy thesis project was dedicated to the study of synucleinopathies. Synucleinopathies are neurodegenerative diseases characterized by the presence of alpha-synuclein positive intracytoplasmic inclusions which are present either in neurons for Parkinson’s disease (i.e. Lewy Bodies) or in oligodendrocytes for Multiple system atrophy (i.e. Glial Cytoplasmic Inclusions). The aim of my work was to establish a multifactorial and translational approach through modeling, mechanistic and therapeutic aspects associated with synucleinopathies. First, we focused on dissecting the underlying alpha-synuclein-mediated mechanisms of neurodegeneration using a non-human primate model of Parkinson’s disease. We confirmed the toxic role of alpha-synuclein in the pathology and highlighted unpredictable cellular processes involved in neurodegeneration. Using the same Parkinson’s disease model, we studied the hypothesis of a pathological propagation between the central and peripheric nervous systems in an attempt to decipher the initiation point and the direction of propagation of the associated pathology. We thus demonstrated a bidirectional route of propagation of alpha-synuclein between the CNS and the ENS and within the ENS. Finally, we focused on the restoration of the autophagic function as a potential common therapeutic target for all synucleinopathies. We demonstrated through a gene-based restoration of the autophagy, we efficiently reestablish alpha-synuclein physiological protein levels, while inducing neuroprotection in a Parkinson’s disease and Multiple system atrophy rodent models. Thus, this work corroborates the key role of alpha-synuclein in the etiology of synucleinopathy and offers new common therapeutic strategies for all synucleinopathies to decrease alpha-synuclein-induced toxicity into the central nervous system
Schumann, Cynthia Mills. "Neuropathology of the amygdaloid complex in autism spectrum disorders /." For electronic version search Digital dissertations database. Restricted to UC campuses. Access is free to UC campus dissertations, 2005. http://uclibs.org/PID/11984.
Повний текст джерелаGolder, Mark Stephen. "An investigation into the neuropathology of uncomplicated diverticular disease." Thesis, Queen Mary, University of London, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.497886.
Повний текст джерелаLiu, Jia [Verfasser], and Adrian [Akademischer Betreuer] Danek. "Neuropathology of Chorea-acanthocytosis / Jia Liu. Betreuer: Adrian Danek." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2014. http://d-nb.info/1098130839/34.
Повний текст джерелаDickson, Jonathan Mark. "The neuropathology of Parkinson's disease : cognitive and motor consequences." Thesis, University of Sheffield, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.340171.
Повний текст джерелаVan, Paesschen Wim. "Quantitative MRI and hippocampal neuropathology of temporal lobe epilepsy." Thesis, University College London (University of London), 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.265249.
Повний текст джерелаMcKavanagh, Rebecca. "The neuropathology of the social cognitive network in autism." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:e189c42c-7c87-470d-ab8f-c6b66a430f5e.
Повний текст джерелаHahn, Caroline Nora. "Central neuropathology and clinicopathological correlates in equine grass sickness." Thesis, University of Edinburgh, 2000. http://hdl.handle.net/1842/30244.
Повний текст джерелаMudariki, Temba. "Diagnostic neuropathology of brain tumours using biophotonics and spectrometry." Thesis, University of Central Lancashire, 2016. http://clok.uclan.ac.uk/16665/.
Повний текст джерелаOrdway, Gregory A. "Neuropathology of Central Norepinephrine in Psychiatric Disorders: Postmortem Research." Digital Commons @ East Tennessee State University, 2007. https://dc.etsu.edu/etsu-works/8613.
Повний текст джерелаLanoue, Amelie Cecile. "Neuropathology in the dorsolateral prefrontal cortex in Parkinson's disease." Thesis, Boston University, 2013. https://hdl.handle.net/2144/11112.
Повний текст джерелаDegeneration of dopaminergic neurons in the substantia nigra pars compacta is the hallmark neuropathological feature of Parkinson's disease (PD). Multiple lines of evidence from anatomical and imaging studies indicate that cell loss or cell dysfunction also occur in other brain regions. The dorsolateral prefrontal cortex (DLPFC) is a region of interest because it could be implicated in both cognitive and motor symptoms of PD. However, studies in this brain region are limited and the extent of pathology is unclear. Work in this thesis was aimed at identifying possible neuropathology in post-mortem PD tissue from Brodmann area 9 (BA9), a region of the DLPFC. In the first study, using design-based stereology and radioisotopic in situ hybridization histochemistry (ISHH), we found that expression of two mitochondrial genes, NDUFS1 and COX1, was not altered and that no global loss of neurons occurs in BA9 in PD. In a second study, using ISHH and gene expression microarray analysis (One-Color Agilent 60-mer Whole Human Genome Microarray), we found decreased gene expression of the GABA-synthesizing enzyme glutamic acid decarboxylase (GAD67) in BA9 in PD, an effect that was not paralleled by a decrease in the numbers of GAD67 mRNA-expressing neurons. In a third study, using ISHH, we found that gene expression of the calcium-binding protein parvalbumin, which is selectively expressed in a subset of cortical GABAergic interneurons, is decreased in BA9 in PD. However, we found no loss of immunolabeled parvalbumin-positive neurons in BA9 in PD. In summary, the results indicate that expression of two key markers of GABAergic activity, GAD67 and parvalbumin, is depressed in BA9 in PD and that these effects are not due to a loss of neurons. This suggests that GABAergic neurotransmission is deficient in the DLPFC in PD and we propose that treatments aimed at restoring GABAergic inhibition in BA9 would have therapeutic efficacy in the symptomatic treatment of PD.
Bristow, Greg. "Investigations of the potential schizophrenia susceptibility gene Kinase Interacting with Stathmin (KIS)." Thesis, University of Oxford, 2010. http://ora.ox.ac.uk/objects/uuid:432fc195-815c-4bc6-945f-c2b59aa3538c.
Повний текст джерелаMochida, Rumi. "Survey of Neuropathology in Obese and Diabetic ZDSD Rat Brain." Available to subscribers only, 2009. http://proquest.umi.com/pqdweb?did=1966536741&sid=1&Fmt=2&clientId=1509&RQT=309&VName=PQD.
Повний текст джерелаThompson, Lachlan H. (Lachlan Heath) 1974. "Receptor and neurochemical changes in models of Alzheimer-like neuropathology." Monash University, Dept. of Pharmacology, 2002. http://arrow.monash.edu.au/hdl/1959.1/7931.
Повний текст джерелаThomas, Alan J. "A study of vascular neuropathology in late-life major depression." Thesis, University of Newcastle Upon Tyne, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.394641.
Повний текст джерелаWest, Daniel Alexander. "The development of experimental models for NMR studies of neuropathology." Thesis, University College London (University of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.406284.
Повний текст джерелаGenoud, Sian. "The role of biometals in the neuropathology of Parkinson’s disease." Thesis, The University of Sydney, 2020. https://hdl.handle.net/2123/22449.
Повний текст джерелаMilosevic, Javorina, Sigrid C. Schwarz, Vera Ogunlade, Anne K. Meyer, Alexander Storch, and Johannes Schwarz. "Emerging role of LRRK2 in human neural progenitor cell cycle progression, survival and differentiation." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-184308.
Повний текст джерелаCullen, Thomas. "The neuropathology of the prefrontal cortex and mediodorsal thalamus in schizophrenia." Thesis, University of Oxford, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.427875.
Повний текст джерелаKam, Korey. "On neuronal hyperexcitability in a mouse model of B-amyloid neuropathology." Thesis, New York University, 2017. http://pqdtopen.proquest.com/#viewpdf?dispub=10192483.
Повний текст джерелаAt present, Alzheimer’s disease (AD) is an incurable neurodegenerative dementia. It has been suggested that neuronal hyperexcitability contributes to AD, so we asked how hyperexcitability develops in a common mouse model of β-amyloid neuropathology - Tg2576 mice. These mice overexpress the Swedish familial mutation of human-amyloid precursor protein (hAPP). Using video-EEG recordings, we found synchronized, large amplitude potentials resembling interictal spikes (IIS) in epilepsy at just 5 weeks of age, long before memory impairments or β-amyloid deposition. Seizures were uncommon, but occurred later in life, suggesting that IIS are possibly the earliest form of hyperexcitability. Interestingly, IIS primarily occurred during rapid-eye movement (REM) sleep prior to the deposition of β-amyloid. The interests are twofold. First, REM sleep is associated with increased cholinergic tone. Second, cholinergic impairments as well as degeneration are implicated in AD. Although previous studies suggest that cholinergic antagonists would worsen pathophysiology, the muscarinic antagonist atropine but not nicotinic antagonists reduced IIS frequency in animals prior to β-amyloid deposition. In addition, we found a role for brain hyperexcitability during general anesthesia. Epileptiform discharges are both hyperexcitable and hypersynchronous across age in Tg2576 mice and wildtypes. Our findings identify that epileptiform discharges elicited during anesthesia mediates cognitive dysfunction and is exacerbated in Aβ depositing brains. Taken together with results from prior studies, the data suggest that surprising and multiple mechanisms contribute to neural hyperexcitability. The data also suggest that IIS during sleep may be a biomarker for early detection of AD.
Manner, Cathyryne Kapiolani. "The consequences of CAT2 arginine transporter ablation in cancer and neuropathology /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2003. http://wwwlib.umi.com/cr/ucsd/fullcit?p3091320.
Повний текст джерелаHeath, P. D. "Cortical somatosensory evoked potentials in parkinsonism." Thesis, University of Oxford, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.233645.
Повний текст джерелаJamieson, Elizabeth Ann. "Distribution and regulation of proteins related to neuronal degeneration." Thesis, University of Glasgow, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.284705.
Повний текст джерелаPaine, Simon Marcus Liddell. "Conditional proteasome gene deletion : molecular neuropathology and the pathogenesis of Parkinson’s disease." Thesis, University of Nottingham, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.580175.
Повний текст джерелаBrown, Nolan J. "Localization of hemoglobin in MS cortex and its relevance to MS neuropathology." Kent State University Honors College / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1399400834.
Повний текст джерелаTurner, Gareth David Huw. "An immunohistochemical study of the pathology of malaria." Thesis, University of Oxford, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.318458.
Повний текст джерелаPearce, Janice. "The trafficking of apolipoprotein E and its effect upon tau phosphorylation." Thesis, King's College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325158.
Повний текст джерелаÖsterman, Hanna. "Olfactory performance and neuropathology in the Tg6799 strain of Alzheimer’s disease model mice." Thesis, Linköpings universitet, Institutionen för fysik, kemi och biologi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-56816.
Повний текст джерелаBayram-Weston, Zubeyde. "Longitudinal characterisation of neuropathology in transgenic and knock-in Huntington's disease mouse lines." Thesis, Cardiff University, 2011. http://orca.cf.ac.uk/14609/.
Повний текст джерелаPurushothuman, Sivaraman. "The neuropathology of age-related degenerations: Cause and protection assessed in rodent models." Thesis, The University of Sydney, 2014. http://hdl.handle.net/2123/11488.
Повний текст джерелаBOI, LAURA. "Neuroinflammation in Parkinson’s Disease: role in neuropathology and L-DOPA-induced motor complications." Doctoral thesis, Università degli Studi di Cagliari, 2020. http://hdl.handle.net/11584/284805.
Повний текст джерелаMilosevic, Javorina, Sigrid C. Schwarz, Vera Ogunlade, Anne K. Meyer, Alexander Storch, and Johannes Schwarz. "Emerging role of LRRK2 in human neural progenitor cell cycle progression, survival and differentiation." Biomed Central, 2009. https://tud.qucosa.de/id/qucosa%3A28998.
Повний текст джерелаTAKAHASHI, AKIRA, YOSHIO HASHIZUME, and NOBUKO UJIHIRA. "A CLINICO-NEUROPATHOLOGICAL STUDY ON BRAIN DEATH." Nagoya University School of Medicine, 1993. http://hdl.handle.net/2237/15930.
Повний текст джерелаSloan, Maximilian. "The behavioural and molecular characterisation of a novel LRRK2 BAC transgenic rat model of Parkinson's disease." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:c2058b71-df43-47cd-a794-13184bacf313.
Повний текст джерелаIRITANI, SHUJI. "What Happens in the Brain of Schizophrenia Patients?: An Investigation from the Viewpoint of Neuropathology." Nagoya University School of Medicine, 2013. http://hdl.handle.net/2237/17597.
Повний текст джерела