Дисертації з теми "Neurons Models"
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Boatin, William. "Characterization of neuron models." Thesis, Available online, Georgia Institute of Technology, 2005, 2005. http://etd.gatech.edu/theses/available/etd-04182005-181732/.
Повний текст джерелаDr. Robert H. Lee, Committee Member ; Dr. Kurt Wiesenfeld, Committee Member ; Dr Robert J. Butera, Committee Member.
Dobbins, Allan C. (Allan Charles). "Difference models of visual cortical neurons." Thesis, McGill University, 1992. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=39539.
Повний текст джерелаEndstopped neurons respond to short or highly curved oriented patterns. Their behaviour results from the difference in activation of their classical receptive field and inhibitory endzones. Two models of endstopped neurons are evaluated mathematically and by computer simulation. It is concluded that a model with displaced complex cell-like endzones is both more computationally robust and more consistent with the physiological evidence.
Other visual cortical neurons have inhibitory zones which are displaced normally rather than tangentially with respect to the neuron's receptive field orientation. These sidestopped cells are selective for narrow patterns. In other visual cortical neurons the side inhibition is derived from a different eye than the classical receptive field. Because of the geometry of projection these are referred to as binocular Near and Far cells. A difference model of sidestopped and Near and Far neurons is developed which captures their principal features.
Neurons in visual cortical area MT of primates have been shown to exhibit a velocity-specific antagonism between the receptive field and a surrounding region. It is argued that center-surround antagonism is an attempt to resolve competing constraints. Signal reliability increases with spatial averaging, but the variation of the flow field invariably increases with area. A unifying perspective is that difference models provide a means of estimating the range over which a visual quantity is constant or linear. Varieties of these models exist with a more refined property--selectivity for sign of contour curvature or, under certain circumstances, the sign of convexity of the surface generating a binocular disparity or motion field.
戚大衛 and Tai-wai David Chik. "A numerical study of Hodgkin-Huxley neurons." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2000. http://hub.hku.hk/bib/B31224210.
Повний текст джерелаQuadroni, Reto. "Realistic models of medial vestibular nuclei neurons /." [S.l.] : [s.n.], 1993. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=10255.
Повний текст джерелаHuss, Mikael. "Computational models of lamprey locomotor network neurons." Licentiate thesis, Stockholm : KTH Numerical Analysis and Computer Science, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-304.
Повний текст джерелаShepardson, Dylan. "Algorithms for inverting Hodgkin-Huxley type neuron models." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2009. http://hdl.handle.net/1853/31686.
Повний текст джерелаCommittee Chair: Tovey, Craig; Committee Member: Butera, Rob; Committee Member: Nemirovski, Arkadi; Committee Member: Prinz, Astrid; Committee Member: Sokol, Joel. Part of the SMARTech Electronic Thesis and Dissertation Collection.
Shaw, Ivan Ting-kun. "Cell death in motor neurons, two complementary models." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape11/PQDD_0028/NQ50259.pdf.
Повний текст джерелаShaw, Ivan Ting-kun 1966. "Cell death in motor neurons : two complementary models." Thesis, McGill University, 1998. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=35486.
Повний текст джерелаWe report similar findings with primary embryonic rat motor neurons identified by surface immunoreactivity for p75 LA NGFR, the low-affinity neurotrophin receptor (Bloch-Gallego et al. 1991; Camu and Henderson 1992; Chao and Hempstead 1995). The p75+ motor neuron population could be maintained for more than 48 hours in mixed suspension cultures supplemented with 10% fetal calf serum. However, the p75+ cell population was rapidly depleted in serum-deprived cultures, a phenomenon accompanied by the appearance of oligonucleosomal ladders. Serum-deprived p75+ cells were supported by the motor neuron-relevant factors BDNF, CNTF, GDNF and IGF-1, but not the non-relevant factor NGF. Serum-deprived p75 + cells were also protected by cycloheximide, suggesting a role for apoptosis in the cell death.
We have investigated the role of reactive oxygen species in acquired and genetic motor neuron diseases. Interestingly, a rapid burst of reactive oxygen species is observable within one hour of serum deprivation in both NSC34 and rat motor neuron systems. This burst precedes measurable cell death by at least one day, indicating that oxygen species generation may be an initial hallmark of target-dependent death. The amplitude and temporal nature of this burst may be altered by manipulating various cellular ROS defence mechanisms. Such manipulations also alter cell death progression, suggesting that the apoptotic cascade may be dependent upon this early ROS burst. The identity, source and activity of the relevant ROS may provide insight into the etiology and treatment of human motor neuron diseases.
Clay, Robert Christopher. "Computer models to simulate ion flow in neurons." Thesis, University of Nottingham, 2017. http://eprints.nottingham.ac.uk/42951/.
Повний текст джерелаMo, Mimi Shin Ning. "Neural vulnerability in models of Parkinson's disease." Thesis, University of Oxford, 2007. http://ora.ox.ac.uk/objects/uuid:ac82e1c1-5d9f-473f-97ac-fcb70b2587ca.
Повний текст джерелаVintch, Brett. "Structured hierarchical models for neurons in the early visual system." Thesis, New York University, 2013. http://pqdtopen.proquest.com/#viewpdf?dispub=3591363.
Повний текст джерелаThe early visual system is composed of a set of anatomically distinct areas that are linked together in a hierarchy. This structure uses simple rules at each stage but supports an impressive array of processing capabilities. In order to capture the full range of these computations, neuronal models in these areas should include this hierarchical architecture. Neurons in the earliest stages receive information directly from sensory transducers, yielding linear-like visual representations that are closely tied to visual stimulation. Neurons further downstream are more abstract and nonlinear in their representation, being both more selective for relevant stimulus visual and invariant across irrelevant features. Despite these computational differences, individual neurons among all areas are anatomically similar and they can be described in simple terms; inputs are summed across dendritic synapses and arbors and outputs are generated by a spiking nonlinearity in the soma and axon hillock. This regularity can be exploited to build simple but powerful hierarchical models that approximate the stages of visual processing in cortex.
A realistic model architecture can reduce, and in some cases eliminated altogether, the need for ad-hoc priors or regularizers. Incorporating physiological and anatomical constraints, and careful experimental design (including the choice of stimuli), simplifies models and allows for more direct and efficient estimation procedures. In this thesis I present a series of hierarchical models for neurons in the early visual system (V1 & V2) and show that they can accurately capture the computations performed by real neurons. I also demonstrate that a stage-wise structure avoids overfitting and that it allows for a more efficient estimation procedure than generic statistical models.
Al-Gonaiah, Majed A. "Investigating xanthine oxidase toxicity models in cultured cerebellar granule neurons." Thesis, University of Glasgow, 2009. http://theses.gla.ac.uk/1057/.
Повний текст джерелаZhou, Yi-Xiong. "Responses to envelope patterns in visual cortical neurons." Thesis, McGill University, 1993. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=41806.
Повний текст джерелаDüsterwald, Kira M. "Exploring the determinants of chloride homeostasis in neurons using biophysical models." Master's thesis, University of Cape Town, 2018. http://hdl.handle.net/11427/29611.
Повний текст джерелаZotov, Alexander. "Models of disparity gradient estimation in the visual cortex." Birmingham, Ala. : University of Alabama at Birmingham, 2007. https://www.mhsl.uab.edu/dt/2008r/zotov.pdf.
Повний текст джерелаPurvis, Liston Keith. "Models of Single Neurons and Network Dynamics in the Medullary Transverse Slice." Diss., Georgia Institute of Technology, 2006. http://hdl.handle.net/1853/14125.
Повний текст джерелаPopova, Dina. "In vitro cellular models for neurotoxicity studies : neurons derived from P19 cells." Doctoral thesis, Umeå universitet, Institutionen för farmakologi och klinisk neurovetenskap, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-133030.
Повний текст джерелаPoznanski, R. R., and L. Lee Glenn. "Estimating the Effective Electrotonic Length of Dendritic Neurons With Reduced Equivalent Cable Models." Digital Commons @ East Tennessee State University, 1994. https://dc.etsu.edu/etsu-works/7549.
Повний текст джерелаWhite, William E. "Use of Empirically Optimized Perturbations for Separating and Characterizing Pyloric Neurons." Ohio University / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1368055391.
Повний текст джерелаBishop, Matthew William. "Electrophysiological properties of midbrain dopamine neurons in genetic mouse models of Parkinson's disease." Thesis, Imperial College London, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.528309.
Повний текст джерелаMeyer, Georg. "Models of neurons in the ventral cochlear nucleus : signal processing and speech recognition." Thesis, Keele University, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.334715.
Повний текст джерелаTakeuchi, Hiroki. "Nicotinic receptor stimulation protects nigral dopaminergic neurons in rotenone-induced Parkinson's disease models." Kyoto University, 2009. http://hdl.handle.net/2433/124255.
Повний текст джерелаLuhr, Katarina. "Prion processing and propagation in neuronal and dendritic cell culture models /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-991-9.
Повний текст джерелаZhang, Xinmei, and 張新梅. "Generation of mouse models to study intracellular transportation in purkinje cells and melanocytes." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B42577779.
Повний текст джерелаZhang, Xinmei. "Generation of mouse models to study intracellular transportation in purkinje cells and melanocytes." Click to view the E-thesis via HKUTO, 2004. http://sunzi.lib.hku.hk/hkuto/record/B42577779.
Повний текст джерелаClarkson, Jenny, and n/a. "Activation of Gonadotropin-releasing hormone neurons by Kisspeptin in the mouse." University of Otago. Department of Physiology, 2008. http://adt.otago.ac.nz./public/adt-NZDU20081208.114143.
Повний текст джерелаMcCormack, Alison. "The non-human primate as a model of human parkinsonism /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-624-7/.
Повний текст джерелаPitcher, Toni Leigh, and n/a. "In vivo electrophysiology of striatal spiny projection neurons in the spontaneously hypertensive rat (SHR)." University of Otago. Department of Anatomy & Structural Biology, 2007. http://adt.otago.ac.nz./public/adt-NZDU20070321.114819.
Повний текст джерелаReid, Michael Steven. "The Role of Heterogeneity in Rhythmic Networks of Neurons." Diss., Georgia Institute of Technology, 2007. http://hdl.handle.net/1853/14565.
Повний текст джерелаKaram, Philippe Chucri. "Modeling passive and active mechanisms in motoneuron dendrites." Thesis, Georgia Institute of Technology, 2003. http://hdl.handle.net/1853/13713.
Повний текст джерелаLaudanski, Jonathan. "Integrate-and-fire models in the auditory system : Dynamics of single neurons and neural populations." Thesis, University of Nottingham, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.523713.
Повний текст джерелаAquili, Luca. "Refinement of biologically inspired models of reinforcement learning." Thesis, St Andrews, 2010. http://hdl.handle.net/10023/886.
Повний текст джерелаAhmadi, Ferogh Ali. "The mechanism of pesticide rotenone-induced cell death in models of Parkinson's disease /." Connect to full text via ProQuest. IP filtered, 2005.
Знайти повний текст джерелаTypescript. Includes bibliographical references (leaves 110-128). Free to UCDHSC affiliates. Online version available via ProQuest Digital Dissertations;
Capanni, Niccolo Francesco. "The functionality of spatial and time domain artificial neural models." Thesis, Robert Gordon University, 2006. http://hdl.handle.net/10059/241.
Повний текст джерелаBrook, Sapoty, and mikewood@deakin edu au. "A physical theory of organisation and consequent neural model of spatio-temporal pattern acquisition." Deakin University. School of Architecture and Engineering, 1987. http://tux.lib.deakin.edu.au./adt-VDU/public/adt-VDU20050825.121850.
Повний текст джерелаZhang, Yalun, and 张亚伦. "Pax6/c-Myb regulates neuronal apoptosis in a mouse model of Alzheimer's disease." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B47331148.
Повний текст джерелаHKU 3 Minute Thesis Award, Champion (2011)
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Biochemistry
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Doctor of Philosophy
Weber, Cornelius. "Maximum a posteriori models for cortical modeling feature detectors, topography and modularity." Saarbrücken VDM Verlag Dr. Müller, 2000. http://d-nb.info/989177149/04.
Повний текст джерелаWeber, Franz. "System identification of optic-flow processing neurons in the fly: single cell and small circuit models." Diss., lmu, 2012. http://nbn-resolving.de/urn:nbn:de:bvb:19-139155.
Повний текст джерелаHoyland, Darren Stephen. "Integrated data collection and automated parameter estimation in the construction of computational models of neostriatal neurons." Thesis, University of Sheffield, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.522410.
Повний текст джерелаFain, Misty, Brooke Beasley, Ryan Abens, Kyla Scott, Wesley Gill, and Michelle Chandley. "NTRK2 Gene Expression Levels in Laser Captured Glutamatergic Neurons From Animal Models of Social Behavior Deficits." Digital Commons @ East Tennessee State University, 2019. https://dc.etsu.edu/asrf/2019/schedule/43.
Повний текст джерелаScullion, Sarah. "Investigating the neurophysiology of layer II/III neurons in the perirhinal cortex in models of dementia." Thesis, University of Bristol, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.684362.
Повний текст джерелаEllis, William Joseph. "Application of statistical mechanics to a model neuron /." Title page, contents and abstract only, 1993. http://web4.library.adelaide.edu.au/theses/09PH/09phe479.pdf.
Повний текст джерелаNorman, Timothy Alfred Jr. "Molecular and morphological analyses of basal forebrain cholinergic neurons in mouse models of aging and Alzheimer's disease." Thesis, Boston University, 2013. https://hdl.handle.net/2144/12173.
Повний текст джерелаBasal forebrain cholinergic neurons (BFCNs) of the medial septal nuclei, the diagonal bands of Broca and the nucleus basalis magnocellularis synthesize acetylcholine (ACh) and their projections extend to the cerebral cortex, hippocampus and the amygdala. ACh neurotransmission is essential for learning, attention, memory, arousal and sleep. BFCNs are dependent on a regulated neurochemical environment for the induction, development, maturation and maintenance of their phenotype and viability. However, events that compromise this neurochemical environment can contribute to BFCN dysfunction and/or degeneration, decreased ACh levels and disrupted brain function. During normal aging and Alzheimer’s disease (AD) BFCNs become more vulnerable to dysfunction due to trophic factor withdrawal, cell signaling impairments and other cytopathologic changes. AD is characterized by the deposition of Amyloid-beta (Aβ) plaques and neurofibrillary Tau tangles (NFTs) in the cortex and hippocampus. These pathological AD hallmarks overlap with cortical and hippocampal cholinergic dysfunction, implicating both as the drivers of cognitive and behavioral decline associated with AD. Since, BFCNs are highly vulnerable to AD pathophysiology, factors that support the BFCN phenotype may have practical use in preserving neuronal networks and cognitive function. There is now strong evidence that bone morphogenetic protein-9 (BMP9 also known as growth/differentiating factor 2, GDF2) acts as an induction and maintenance factor that regulates BFCN differentiation in-vitro and in-vivo. Here we used transgenic mice that express green fluorescent protein (GFP) in BFCNs to make observations concerning the BFCN phenotype in aging and AD. We found qualitative evidence that BFCNs of the 24-month old WT/ChAT-GFP mice were smaller and more rounded with shorter processes when compared to 6- month old mouse BFCNs. We analyzed the effects of intracerebroventricular infusion of BMP9 on BFCN projection fibers in the APPswe/PS1dE9 mouse model of AD using laser scanning confocal microscopy. BMP9 not only increased the density of cholinergic projection fibers in the hippocampus of wild type and AD model APPswe/PS1dE9 mice, but it also reduced the plaque burden in the hippocampus of the AD mouse model. These data indicate that BMP9 ameliorated two major pathophysiologic hallmarks of AD, observable in these transgenic APPswe/PS1dE9 mice. BMP9 reduced Aβ plaque burden in this AD model, and enhanced the outgrowth and viability of cholinergic fibers within the hippocampus of both wild-type and APPswe/PS1dE9 mice. [TRUNCATED]
Kaplan, Eitan S. "Visual cortical plasticity : the role of parvalbumin expressing inhibitory neurons and abnormalities in models of neurodevelopmental disorders." Thesis, Massachusetts Institute of Technology, 2016. http://hdl.handle.net/1721.1/103210.
Повний текст джерелаCataloged from PDF version of thesis. Vita.
Includes bibliographical references (pages 121-134).
The roles played by cortical inhibitory neurons in experience-dependent plasticity and learning are not well understood. Here we evaluate the participation of parvalbumin-expressing (PV+) GABAergic neurons in two forms of experience-dependent modification of primary visual cortex (V1) in adult mice: ocular dominance (OD) plasticity resulting from monocular deprivation and stimulus-selective response potentiation (SRP) resulting from supplemental visual experience. These two forms of plasticity are triggered by different events but lead to a similar increase in visual cortical response. Both also require the NMDA class of glutamate receptor (NMDAR). However, we find that PV+ inhibitory neurons in V1 play a critical role in the expression of SRP and its behavioral correlate of familiarity recognition, but not in the expression of OD plasticity. Furthermore, NMDARs expressed within PV+ cells play a critical role in SRP, but not in the induction or expression of adult OD plasticity. We also explore the use of visual cortical plasticity paradigms to better understand the function of proteins implicated in autism spectrum disorders (ASDs) and schizophrenia. We find that NMDAR-dependent long-term depression (LTD) and deprived-eye depression in layer 4 of V1 require metabotropic glutamate receptor 5 (mGluR5) signaling during postnatal development. Additionally, schizophrenia-associated protein neurogranin overexpression in V1 disrupts juvenile ocular dominance plasticity. Finally, we evaluate SRP in two models of ASDs associated with excitatory/ inhibitory imbalance: Rett syndrome (RTT) and tuberous sclerosis complex (TSC). Surprisingly, mouse models of RTT and TSC exhibit abnormal SRP phenotypes, but in opposite directions.
by Eitan S. Kaplan.
Ph. D. in Neuroscience
Wedin, Mattias, and Isak Bengtsson. "A Comparative Study on Machine Learning Models for Automatic Classification of Cell Types from Digitally Reconstructed Neurons." Thesis, KTH, Skolan för elektroteknik och datavetenskap (EECS), 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-301744.
Повний текст джерелаUnder det senaste decenniet har användningen av maskininlärning i neurovetenskaplig forskning blivit ett populärt ämne. Exempelvis har bildigenkänning med hjälp av maskininlärning använts för att upptäcka och även förbättra diagnostisering av sjukdomar. I denna studie jämförs noggrannheten i ett Convolutional Neural Network (CNN), en support vector classifier och en random forest classifier för att undersöka vilka som är bättre lämpade för klassificering av celltyper utifrån digitalt rekonstruerade bilder av hjärnceller från möss. Alla modeller tränades på både ett större obalanserad dataset som innehöll 49 olika celltyper och en mindre balanserat dataset som endast innehöll 3 typer. Varje modell utvärderades på hur väl de kunde klassificera alla celltyper men också deras noggrannhet på enskilda celltyper. Resultaten visade att CNN hade bästa medelprecision, med 51 och 83 procent på respektive datamängder. Vid klassificeringen av enskilda celltyper hade alla modeller god noggrannhet på åtminstone några celltyper, även här hade CNN den bästa individuella noggrannheten och var mer konsekvent. Sammanfattningsvis visar resultaten att ett convolutional neural network förmodligen är bättre lämpad vid klassificerar av celltyper från digitalt rekonstruerade bilder av hjärnceller, men även de andra metoderna kan vara lämpliga vid vissa celltyper. Vidare forskning inom ämnet är dock nödvändigt för att nå en högre precision och pålitlighet av resultatet.
Jiang, Lixian. "Interactions of Neurons, Astrocytes and Microglia with HUCB Cell Populations in Stroke Models: Migration, Neuroprotection and Inflammation." [Tampa, Fla] : University of South Florida, 2008. http://purl.fcla.edu/usf/dc/et/SFE0002552.
Повний текст джерелаOcchipinti, Rossana. "In Silico Testing of Hypotheses for Brain Energy Metabolism with New Computational Models within a Statistical Framework." Case Western Reserve University School of Graduate Studies / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=case1244144388.
Повний текст джерелаTofighi, Roshan. "In vitro models to study mechanisms of neural cell death induced by toxic agents /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-459-4/.
Повний текст джерелаGalpern, Wendy R. "Neuroprotection and Neurotransplantation Strategies in Models of Parkinson’s Disease." eScholarship@UMMS, 1996. https://escholarship.umassmed.edu/gsbs_diss/143.
Повний текст джерелаShi, Tie-Jun. "Regulation of signaling molecules in sensory neurons and spinal cord : studies on nerve injury models and transgenic mice /." Stockholm, 2001. http://diss.kib.ki.se/2001/91-628-4837-2/.
Повний текст джерела