Дисертації з теми "Neural cultures"
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De, La Garza Richard. "Determination of neuronal morphology in spinal monolayer cultures." Thesis, University of North Texas, 1989. https://digital.library.unt.edu/ark:/67531/metadc798395/.
Повний текст джерелаAmaral, Ana Isabel Porém. "Metabolic flux analysis of neural cell metabolism in primary cultures." Doctoral thesis, Universidade Nova de Lisboa. Instituto de Tecnologia Química e Biológica, 2011. http://hdl.handle.net/10362/6849.
Повний текст джерелаBrain energy metabolism results from a complex group of pathways and trafficking mechanisms between all cellular components in the brain, and importantly provides the energy for sustaining most brain functions. In recent decades, 13C nuclear magnetic resonance (NMR) spectroscopy and metabolic modelling tools allowed quantifying the main cerebral metabolic fluxes in vitro and in vivo. These investigations contributed significantly to elucidate neuro-glial metabolic interactions, cerebral metabolic compartmentation and the individual contribution of neurons and astrocytes to brain energetics. However, many issues in this field remain unclear and/or under debate.
To the financial support provided by Fundação para a Ciência a Tecnologia (SFRH/BD/29666/2006; PTDC/BIO/69407/2006) and to the Clinigene – NoE (LSHBCT2006- 010933). I further acknowledge the Norwegian Research Council for a fellowship that allowed me to perform part of my PhD work at NTNU, Norway.
Cullen, Daniel Kacy. "Traumatically-Induced Degeneration and Reactive Astrogliosis in 3-D Neural Co-Cultures: Factors Influencing Neural Stem Cell Survival and Integration." Diss., Georgia Institute of Technology, 2005. http://hdl.handle.net/1853/7584.
Повний текст джерелаCullen, Daniel Kacy. "Traumatically-induced degeneration and reactive astrogliosis in three-dimensional neural co-cultures." Available online, Georgia Institute of Technology, 2005, 2005. http://etd.gatech.edu/theses/available/etd-11282005-210117/.
Повний текст джерелаRobert McKeon, Committee Member ; Robert Lee, Committee Member ; Robert Guldberg, Committee Member ; Ravi Bellamkonda, Committee Member ; Michelle LaPlaca, Committee Chair. Vita.
Liu, Ning. "Expansion and Neural Differentiation of Embryonic Stem Cells in Three-Dimensional Cultures." The Ohio State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=osu1262281522.
Повний текст джерелаRioult-Pedotti, Marc Guy. "Optical multisite recording of neural activity patterns in organotypic spinal cord tissue cultures /." [S.l.] : [s.n.], 1991. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=9393.
Повний текст джерелаOlivero, Daniel. "Traumatic brain injury biomarker discovery using mass spectrometry imaging of 3D neural cultures." Thesis, Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/41102.
Повний текст джерелаBakkum, Douglas James. "Dynamics of embodied dissociated cortical cultures for the control of hybrid biological robots." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2007. http://hdl.handle.net/1853/22596.
Повний текст джерелаCommittee Chair: Steve M. Potter; Committee Member: Eric Schumacher; Committee Member: Robert J. Butera; Committee Member: Stephan P. DeWeerth; Committee Member: Thomas D. DeMarse.
Madhavan, Radhika. "Role of spontaneous bursts in functional plasticity and spatiotemporal dynamics of dissociated cortical cultures." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2007. http://hdl.handle.net/1853/24756.
Повний текст джерелаCommittee Chair: Potter, Steve; Committee Member: Butera, Robert; Committee Member: DeWeerth, Stephen; Committee Member: Schumacher, Eric; Committee Member: Wenner, Pete.
McLoughlin, Justin. "A novel in vitro shear device for inducing high strain rate deformation on neural cell cultures." Thesis, Georgia Institute of Technology, 2000. http://hdl.handle.net/1853/16011.
Повний текст джерелаPark, Deric M., Jinkyu Jung, Jimmy Masjkur, Stylianos Makrogkikas, Doreen Ebermann, Sarama Saha, Roberta Rogliano, et al. "Hes3 regulates cell number in cultures from glioblastoma multiforme with stem cell characteristics." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2013. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-127014.
Повний текст джерелаTeller, Amado Sara. "Functional organization and networ resilience in self-organizing clustered neuronal cultures." Doctoral thesis, Universitat de Barcelona, 2016. http://hdl.handle.net/10803/396114.
Повний текст джерелаDesvelar la relación entre la red de conexiones anatómica y su emergente dinámica es uno de los grandes desafíos de la neurociencia actual. En este sentido, los cultivos neuronales han tomado un papel muy importante para entender esta cuestión, ya que fenomenologías fundamentales pueden ser estudiadas a escalas más tratables. Los cultivos neuronales se obtienen típicamente a base de disociar tejido neuronal de una parte específica del cerebro, corteza cerebral de rata en nuestro caso, y su cultivo en un medio adecuado. Neuronas en cultivo constituyen en 1-2 semanas una red nueva con una actividad espontánea rica. Una de las preparaciones in vitro que ofrece mayor potencial es las 'redes clusterizadas'. Estas redes se auto-organizan de forma natural, formando grupos de neuronas (clústeres) interconectados a través de axones. La caracterización de la dinámica de estas redes clusterizadas, así como su sensibilidad a perturbaciones, ha sido el objetivo principal de esta tesis. Así, hemos caracterizado la red funcional del cultivo a partir de su dinámica espontánea, desarrollando para ello un novedoso modelo fisicomatemático. Hemos observado que las redes tienen una conectividad modular, donde clústeres tienden a conectarse fuertemente en pequeños grupos, los cuales a su vez se conectan entre ellos. Además, las redes funcionales muestran propiedades topológicas clave, en especial asortatividad (interconexión preferente de clústeres con número similar de conexiones) y la existencia de un 'rich club' (grupo de clústeres con una interconectividad tan destacada que forman el núcleo fundamental de la red). Estas propiedades confieren una gran robustez y flexibilidad a la red. Por esta razón, en la tesis hemos investigado diferentes perturbaciones físicas y bioquímicas, demostrando que las redes clusterizadas son mucho más resistentes a daño que otras configuraciones, lo que refuerza la relación entre las propiedades topológicas descritas y resistencia al daño. Además, observamos que las redes presentaron diferentes mecanismos de reforzamiento entre conexiones para preservar la actividad de la red. Por ello, las redes clusterizadas constituyen una plataforma ideal para estudiar resistencia en redes o como sistema modelo aplicado a estudios de enfermedades neurodegenerativas, como por ejemplo Alzheimer.
Sparks, Christopher A. "Investigations of neuronal network responses to electrical stimulation in murine spinal cultures." Thesis, University of North Texas, 2001. https://digital.library.unt.edu/ark:/67531/metadc3027/.
Повний текст джерелаLabour, Marie-Noëlle. "Collagène auto-assemblé en support 3D biomimétique fonctionnalisé pour la différenciation de cellules nerveuses." Thesis, Montpellier 1, 2012. http://www.theses.fr/2012MON13508/document.
Повний текст джерелаThe objective of this work was to develop a 3D compartmented cell culture set-up that allow the differentiation of nerve cells and the growth of neurites in the matrix depth. Biomimetic materials enable the formation of controlled microenvironments that orient cell behavior. They are particularly interesting for fundamental studies that aim to study signaling pathways involved in physiologic or pathologic processes. We focused on Alzheimer's disease, in which dystrophic neurites are associated to amyloid plaques. No direct relationship has yet been established between Aβ aggregates-neurite interaction, neurite dystrophy and cell death. First, we described and characterized the structure and properties of fibrillar collagen matrices with adapted thickness. Then, we adjusted functionalization of these matrices with neurotrophic growth factors (NGF and BDNF). Two methods were studied: impregnation/release and covalent coupling. Cell morphology studies confirmed that these functionalized matrices were efficient supports for nerve cells differentiation (PC-12 and SH-SY5Y). Finally, we have characterized Aβ aggregates that were formed inside collagen matrices by coprecipitation of amyloid peptide and collagen and we studied their toxicity on neural cells
Luca, Luminita Eugenia. "Oxygen Glucose Deprivation and Hyperthermia Induce Cellular Damage in Neural Precursor Cells and Immature Neurons." Scholarly Repository, 2008. http://scholarlyrepository.miami.edu/oa_dissertations/184.
Повний текст джерелаVernekar, Varadraj Nagesh. "Optimization of 3-d neural culture and extracellular electrophysiology for studying injury-induced morphological and functional changes." Diss., Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/39624.
Повний текст джерелаRambani, Komal. "Thick brain slice cultures and a custom-fabricated multiphoton imaging system: progress towards development of a 3D hybrot model." Thesis, Georgia Institute of Technology, 2007. http://hdl.handle.net/1853/22702.
Повний текст джерелаGarrido-Sanchez, Luis Edmundo. "Conception et mise en œuvre d'un système d'aide a la modélisation de procédés de fermentation utilisant un système expert et des réseaux de neurones." Vandoeuvre-les-Nancy, INPL, 1993. http://www.theses.fr/1993INPL023N.
Повний текст джерелаMorefield, Samantha I. (Samantha Irene). "Responses of Cultured Neuronal Networks to the Cannabinoid Mimetic Anandamide." Thesis, University of North Texas, 1998. https://digital.library.unt.edu/ark:/67531/metadc277717/.
Повний текст джерелаBeattie, Allison Jane. "Organised neural networks in culture." Thesis, University of Glasgow, 2006. http://theses.gla.ac.uk/1921/.
Повний текст джерелаMurphy, Eric James. "Cell culture models for neural trauma /." The Ohio State University, 1989. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487672245901403.
Повний текст джерелаIshikawa, Masaaki. "Transplantation of neurons derived from human iPS cells cultured on collagen matrix into guinea-pig cochleae." 京都大学 (Kyoto University), 2017. http://hdl.handle.net/2433/225472.
Повний текст джерелаWiskow, Ole. "Evaluation of the neuronal differentiation capacity of pluripotent stem cells and neural stem cells in monolayer culture." Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609417.
Повний текст джерелаGuo, Aobo. "Progranulin (PGRN) functions in neuronal cultures." Thesis, University of British Columbia, 2009. http://hdl.handle.net/2429/12702.
Повний текст джерелаEriksson, Malin. "Manipulating neural stem cells." Stockholm, 2010. http://diss.kib.ki.se/2010/978-91-7409-853-2/.
Повний текст джерелаCorradini, Daniele. "Statistical characterization of cultured neural networks activity recorded via MEA." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2020. http://amslaurea.unibo.it/20380/.
Повний текст джерелаKeefer, Edward W. "Unique applications of cultured neuronal networks in pharmacology, toxicology, and basic neuroscience." Thesis, University of North Texas, 2001. https://digital.library.unt.edu/ark:/67531/metadc2797/.
Повний текст джерелаDe, Faria Da Fonseca Bárbara. "Regulation of Mesenchymal Differentiation Potentials in the avian Neural Crest." Thesis, Paris 6, 2017. http://www.theses.fr/2017PA066146/document.
Повний текст джерелаThe neural crest (NC) is a transitory multipotent structure of the vertebrate embryo. The cephalic NC (CNC), not the trunk NC (TNC), gives rise to mesenchymal cell types (contributing to craniofacial skeleton, dermis and adipose tissue). This capacity of the CNC has been linked to the absence of Hox gene expression in the most rostral region of the embryo. However, TNC cells do have mesenchymal potentialities, although in a dormant state in vivo, but which can be disclosed after NC in vitro culture. The molecular mechanisms that regulate mesenchymal potentials of the NC cells along the rostral-caudal axis are still elusive. Here, we have used the avian embryo model to investigate the possible influence on NC mesenchymal fate, of Hox and Six transcription factor genes. On the one hand, in vivo and in vitro culture analyses show that Six1 gene is expressed in mesenchymal cell populations derived from both cranial NC and mesoderm, suggesting a role for Six1 in muscle-skeletal development in the head. On the other hand, we have tested the hypothesis of an inhibitory action of Hox genes on NC cell mesenchymal differentiation using NC in vitro cultures. In CNC cells, we found that ectopic expression of Hoxa2 strongly reduces the production of osteoblasts, while neural and melanocytic phenotypes are unaffected. In the cultured CNT cells, overexpression of Hoxa2 results in largely impaired differentiation into bone cells, chondrocytes and adipocytes, whereas other NC derivatives are unchanged. These results suggest that mesenchymal potentials of the CNC and TNC are controlled, at least in part, via a common mechanism that involves inhibition of Hoxa2 gene activity
Santa, Maria Cara L. "Optimization of Cell Culture Procedures for Growing Neural Networks on Microelectrode Arrays." Thesis, University of North Texas, 2007. https://digital.library.unt.edu/ark:/67531/metadc5126/.
Повний текст джерелаDian, Emese Emöke. "Application of Cultured Neuronal Networks for Use as Biological Sensors in Water Toxicology and Lipid Signaling." Thesis, University of North Texas, 2004. https://digital.library.unt.edu/ark:/67531/metadc5557/.
Повний текст джерелаJohnston, D. A. "The avian neural crest : behaviour and long-term survival in culture." Thesis, University of Southampton, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.376464.
Повний текст джерелаRogers, A. T. "Spinal cord cell culture : a model for neuronal development and disease." Thesis, University of Bath, 1988. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.234048.
Повний текст джерелаJohnston, Helen Barbara. "An investigation of aluminium neurotoxicity using in vitro neural culture systems." Thesis, University of Hertfordshire, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.358304.
Повний текст джерелаJones, Erin Boote. "Effects of substrate and co-culture on neural progenitor cell differentiation." [Ames, Iowa : Iowa State University], 2008.
Знайти повний текст джерелаKarbanová, Jana, Tomáš Soukup, Jakub Suchánek, Robert Pytlík, Denis Corbeil, and Jaroslav Mokrý. "Characterization of Dental Pulp Stem Cells from Impacted Third Molars Cultured in Low Serum-Containing Medium." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-136045.
Повний текст джерелаDieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich
Xydas, Dimitris. "Investigation of spatiotemporal state dynamics in neuronal cultures." Thesis, University of Reading, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.558807.
Повний текст джерелаJohnstone, Alex. "Microfluidic systems for neuronal cell culture." Thesis, University of Nottingham, 2016. http://eprints.nottingham.ac.uk/37822/.
Повний текст джерелаKonagaya, Shuhei. "Design of cell culture substrates for large-scale preparation of neural cells." 京都大学 (Kyoto University), 2013. http://hdl.handle.net/2433/174963.
Повний текст джерелаSanta, Maria Cara L. Gross Guenter W. "Optimization of cell culture procedures for growing neural networks on microelectrode arrays." [Denton, Tex.] : University of North Texas, 2007. http://digital.library.unt.edu/permalink/meta-dc-5126.
Повний текст джерелаJiang, Xiaosong. "Muscle induces neuronal expression of acetylcholinesterase in neuron-muscle co-culture : transcription regulation mediated by cAMP-dependent signaling /." View Abstract or Full-Text, 2003. http://library.ust.hk/cgi/db/thesis.pl?BIOL%202003%20JIANG.
Повний текст джерелаIncludes bibliographical references (leaves 132-149). Also available in electronic version. Access restricted to campus users.
Karbanová, Jana, Tomáš Soukup, Jakub Suchánek, Robert Pytlík, Denis Corbeil, and Jaroslav Mokrý. "Characterization of Dental Pulp Stem Cells from Impacted Third Molars Cultured in Low Serum-Containing Medium." Karger, 2011. https://tud.qucosa.de/id/qucosa%3A27697.
Повний текст джерелаDieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
Gómez, Orlandi Javier. "Noise, coherent activity and network structure in neuronal cultures." Doctoral thesis, Universitat de Barcelona, 2015. http://hdl.handle.net/10803/346925.
Повний текст джерелаAlbutt, Darren James. "Surface chemistry modification of glass and gold for low density neural cell culture." Thesis, University of Nottingham, 2013. http://eprints.nottingham.ac.uk/13823/.
Повний текст джерелаFonseca, Erika Toledo da. "Identificação de áreas neurogênicas no sistema nervoso central de cobaias (Cavia porcellus, Linnaeus 1758): cultura, caracterização e diferenciação de precursores neurais." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/10/10132/tde-04072013-120221/.
Повний текст джерелаThe present study concerns the identification of neurogenic areas, culture, identification and characterization of neural precursors obtained from the brain of guinea pigs. Potentially neurogenic areas in the brain of neonates were identified by immunohistochemistry for bromodeoxyuridine (BrdU), following administration of the drug. BrdU incorporation was detected mainly in cells underlying the lateral ventricle, in hippocampus and olfactory bulbs, indicating cell proliferation and suggesting a neurogenic potential for these areas. Subsequently, neural precursors were cultured from cells obtained from the subventricular zone (SVZ) of the lateral ventricles. After approximately one week culture, SVZ cells in active multiplication originated abundant cellular masses (neurospheres, NSFs). Cells dissociated from primary NSFs were capable of originating new NSFs after a few days of culture. NSFs proliferated in number and size, allowing 5-6 weekly subculturings and maintaining growth and viability for up to 60 days. In the meantime, NSFs were frozen and thawed, maintaining the viability and proliferative ability. Viability assays by the colorimetric MTT revealed viability differences among NSFs originated from SVZs from animals of different ages (fetuses, 7, 30 and 180 days of age). Dissociated NSFs underwent approximately 2.3% cell death by apoptosis and 3.1% death by necrosis. Intact and dissociated NSFs were submitted to immunofluorescence (IF), using antibodies for cell markers of stem cells (nestin), neurons (beta-III tubulin), oligodendrocytes (mGalC) and astrocytes (GFAP). A diffuse staining of variable intensity was observed in the cytoplasm of NSFS and dissociated cells, yet the rate of cells expressing each individual marker could not be determined. Upon culture in medium containing B27, without NSFs-specific growth factors, NSFs displayed evidence of neural differentiation, originating cells with morphology distinct from that of NSFs, suggesting differentiation. Flow cytometry analysis of NSFs cells after differentiation revealed approximately 13.3% positive for nestin, around 5.5% positive for beta-III-tubulin, 9% GFAP positive and approximately 7.8% positive for mGalC. Differentiated cells were then submitted to a functional test, by measuring calcium influx upon gamma butiric amino acid (GABA) and glutamate stimuli. GABA and glutamate stimulated some differentiated cells. Thus, cells cultured and differentiated from guinea pig SVZ present physiological indicators of neuronal physiology. Thus, the ability of guinea pig SVZ cells to originate functional neurons in vitro is promising towards further studies and potential therapeutic use of neural stem cells in disorders of the nervous system.
Cēbers, Gvido. "Modulation of AMPA glutamate receptor functions in primary neuronal cultures /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3424-X/.
Повний текст джерелаFardet, Tanguy. "Growth and activity of neuronal cultures : emergence of organized behaviors." Thesis, Sorbonne Paris Cité, 2018. http://www.theses.fr/2018USPCC002/document.
Повний текст джерелаIn this thesis, I provide models and numerical tools to better understand and predict the behavior and development of neuronal cultures and devices.Neuronal cultures have proven invaluable in improving our understanding of how the brain processes information, by enabling researchers to investigate neuronal and network response functions to various perturbations and stimuli.Furthermore, recent progress in microfluidics have opened the gate towards more elaborated neuronal devices, bringing us one step closer to complex signal processing with living in vitro neurons.In a first part, I propose a mechanism to explain the epileptiform bursts of activity present in cultures, mechanism which I formulate as a concise theoretical model. I subsequently test the predictions of this model on cultures and show that they are indeed compatible with the behavior observed in vitro.I further develop this description in the second part of the thesis, where I analyze its spatiotemporal dynamics and the fact that burst nucleate in specific areas in the network.Since predictions and analysis of these nucleation centers strongly depends on the network structure, I develop a simulation platform to enable efficient modeling of the network development. This software takes into account the interactions between the neurons and their environment and is the first platform to provide versatile and complete models to simulate the entire growth process of neurons. I demonstrate that this simulator is able to generate valid neuronal morphologies, then use it to propose new network topologies to describe neuronal cultures, as well as to reproduce existing neuronal devices. I then show that the activities sustained by these structures are compatible with the experimental recordings.Eventually, I discuss several future directions for which the use of neuronal devices would enable to circumvent current limitations of neuronal cultures, thus providing new information on the processes which underlie brain development and plasticity
Kershaw, Timothy Richard. "The development and transplantation of neural cell lines from the H-2K'b-tsA58 transgenic mouse." Thesis, King's College London (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.244043.
Повний текст джерелаChao, Zenas C. "Toward the neurocomputer goal-directed learning in embodied cultured networks/." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2007. http://hdl.handle.net/1853/19816.
Повний текст джерелаCommittee Chair: Potter, Steve; Committee Member: Butera, Robert; Committee Member: DeMarse, Thomas; Committee Member: Jaeger, Dieter; Committee Member: Lee, Robert.
Joshi, Pranav. "Three-Dimensional Human Neural Stem Cell Culture for High-Throughput Assessment of Developmental Neurotoxicity." Cleveland State University / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=csu155965254496159.
Повний текст джерелаShi, Xinglong. "DIFFERENTIATION OF NEURAL STEM CELL USING SMALL MOLECULES IN 2D AND 3D CULTURE SYSTEM." Master's thesis, Temple University Libraries, 2015. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/363660.
Повний текст джерелаM.S.
The neuronal differentiation of neural stem cells (NSCs) has received much attention due to its potential for the treatment of neurodegenerative diseases (i.e., Parkinson’s and Alzheimer’s diseases). In this regard, discovering compounds that direct differentiation of NSCs is highly required to facilitate therapeutic applications. In this study, we examined various bioactive compounds (SA1, SA2, LiCl, compound B, and DHED) to induce the neuronal differentiation of human neural stem cells (hNSCs). The study was conducted on the cells grown in three dimensional (3D) hydrogel or two dimensional (2D) environment since 3D hydrogel mimics the extracellular matrix and provides physiologically more relevant environment than 2D cell culture system. Three-dimensional (3D) hydrogel systems in this study involve polysaccharides such as alginate and hyaluronic acid. Neuronal differentiation of hNSCs was monitored in genetic level and protein level by quantitative reverse transcription polymerase chain reaction (RT-qPCR) and immunocytochemistry (ICC), respectively. This study will show the effect of bioactive compounds on hNSCs differentiation in 2D and 3D culture systems.
Temple University--Theses