Статті в журналах: "Neglected Infectious disease"

1

Burki, Talha. "Neglected people and a neglected disease." Lancet Infectious Diseases 9, no. 5 (May 2009): 280. http://dx.doi.org/10.1016/s1473-3099(09)70125-2.

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2

Machado, Fabiana S., Herbert B. Tanowitz, and Mauro M. Teixeira. "New drugs for neglected infectious diseases: Chagas' disease." British Journal of Pharmacology 160, no. 2 (April 26, 2010): 258–59. http://dx.doi.org/10.1111/j.1476-5381.2010.00662.x.

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3

Al Yamani, Abrar Abdulfattah, Yahya Mohammad Falqi, Yussif Mohammed Alnawar, Lama Mohammed Almahrous, Haitham Ahmed Alwael, Ali Ibrahim Al Muhaif, Hebah Adel Mansour, et al. "Neglected infectious diseases in the geriatrics." International Journal Of Community Medicine And Public Health 9, no. 1 (December 27, 2021): 353. http://dx.doi.org/10.18203/2394-6040.ijcmph20214862.

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Infectious diseases in the elderly population pose a significant threat to their lives. Neglected tropical diseases significantly impact the health of the affected patients and populations at risk. Reports show that many of these disorders are among the highest ten most typical causes of disability-adjusted life years. In the present literature review, we have discussed the most common neglected tropical infections in geriatrics based on data from the current studies in the literature. Different infections can affect the geriatric population. However, evidence shows that this population is susceptible to developing severe disease-related conditions. This has been reported with dengue infection, onchocerciasis, and cholera. It has been demonstrated that ocular lesions and other clinical manifestations are highest among the elderly population with onchocerciasis. Severe dengue and dengue hemorrhagic fever are also reported at a high rate in this age group. Concurrent infections and disorders were documented with many of these infections, probably due to reduced immunity. Socioeconomic factors, co-morbidities, access to healthcare settings, environmental factors, sanitation, clustering, and overcrowding contribute to the frequency of neglected tropical diseases in the elderly. Further studies are still needed because the current report is scarce, which might underestimate the current evidence.

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4

Quan, Song Ji, Malumani Malan, and Chiyenu O. R. Kaseya. "Hansen's Disease: A Neglected Tropical Infectious Condition." Medical Journal of Zambia 46, no. 3 (December 31, 2019): 243–47. http://dx.doi.org/10.55320/mjz.46.3.564.

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This case of Hansen's disease reminds clinicians of all ages and era that leprosy is not a disease of the past as such a systematized multidisplinary approach and timely referral to specialists should be followed when evaluating any patient with chronic dermatoses of unknown cause.Early diagnosis of leprosy coupled with prompt treatment with Multi Drug Therapy (MDT) are the most important steps in preventing permanent debilitating deformity and disability.

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5

Nii-Trebi, Nicholas Israel. "Emerging and Neglected Infectious Diseases: Insights, Advances, and Challenges." BioMed Research International 2017 (2017): 1–15. http://dx.doi.org/10.1155/2017/5245021.

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Infectious diseases are a significant burden on public health and economic stability of societies all over the world. They have for centuries been among the leading causes of death and disability and presented growing challenges to health security and human progress. The threat posed by infectious diseases is further deepened by the continued emergence of new, unrecognized, and old infectious disease epidemics of global impact. Over the past three and half decades at least 30 new infectious agents affecting humans have emerged, most of which are zoonotic and their origins have been shown to correlate significantly with socioeconomic, environmental, and ecological factors. As these factors continue to increase, putting people in increased contact with the disease causing pathogens, there is concern that infectious diseases may continue to present a formidable challenge. Constant awareness and pursuance of effective strategies for controlling infectious diseases and disease emergence thus remain crucial. This review presents current updates on emerging and neglected infectious diseases and highlights the scope, dynamics, and advances in infectious disease management with particular focus on WHO top priority emerging infectious diseases (EIDs) and neglected tropical infectious diseases.

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6

Olesen, Ole F., and Marit Ackermann. "Increasing European Support for Neglected Infectious Disease Research." Computational and Structural Biotechnology Journal 15 (2017): 180–84. http://dx.doi.org/10.1016/j.csbj.2017.01.007.

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7

Elsner, P., and T. Agner. "Hand eczema: a ‘neglected’ disease." Journal of the European Academy of Dermatology and Venereology 34, S1 (December 20, 2019): 3. http://dx.doi.org/10.1111/jdv.16081.

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8

Zijlstra, Eduard E., Wendy W. J. van de Sande, Oliverio Welsh, El Sheikh Mahgoub, Michael Goodfellow, and Ahmed H. Fahal. "Mycetoma: a unique neglected tropical disease." Lancet Infectious Diseases 16, no. 1 (January 2016): 100–112. http://dx.doi.org/10.1016/s1473-3099(15)00359-x.

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9

Srour, M. Leila, and Denise Baratti-Mayer. "Why is noma a neglected-neglected tropical disease?" PLOS Neglected Tropical Diseases 14, no. 8 (August 20, 2020): e0008435. http://dx.doi.org/10.1371/journal.pntd.0008435.

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10

Marsh, K. "Malaria-a neglected disease?" Parasitology 104, S1 (June 1992): S53—S69. http://dx.doi.org/10.1017/s0031182000075247.

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SUMMARYIn situations where malaria eradication is not an option in the foreseeable future the emphasis must be on the control of morbidity and mortality due to malaria. Under such circumstances drawing a distinction between malarial parasitization and malarial disease may be important for workers in both field and laboratory. This concept is explored from the points of view of the epidemiological picture of malaria in endemic populations, the factors which may influence progression to disease and the processes which mediate disease.

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11

Crager, Sara E., and Matt Price. "Prizes and Parasites: Incentive Models for Addressing Chagas Disease." Journal of Law, Medicine & Ethics 37, no. 2 (2009): 292–304. http://dx.doi.org/10.1111/j.1748-720x.2009.00373.x.

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Despite the enormous progress made in the advancement of health technologies over the last century, infectious diseases continue to cause significant morbidity and mortality in developing countries. Neglected diseases are a subset of infectious diseases that lack treatments that are effective, simple to use, or affordable. Neglected diseases primarily affect populations in poor countries that do not constitute a lucrative market sector, thus failing to provide incentives for the pharmaceutical industry to conduct R&D for these diseases. Of the treatments that do exist for neglected diseases, most are completely out-dated, with poor side-effect profiles, cumbersome logistics of administration, and inadequate efficacy. Historically, the impetus for a majority of neglected disease research was driven by early 20th-century colonialism, and in the post-colonial era, these diseases have been virtually ignored. Of the 1556 New Chemical Entities (NCEs) brought to market during the 30-year period from 1975 to 2004, only 20 — less than 0.02% — were for neglected diseases.

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12

Furuse, Yuki. "Analysis of research intensity on infectious disease by disease burden reveals which infectious diseases are neglected by researchers." Proceedings of the National Academy of Sciences 116, no. 2 (December 31, 2018): 478–83. http://dx.doi.org/10.1073/pnas.1814484116.

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Infectious diseases are associated with considerable morbidity and mortality worldwide. Although human, financial, substantial, and time resources are limited, it is unknown whether such resources are used effectively in research to manage diseases. The correlation between the disability-adjusted life years to represent disease burden and number of publications as a surrogate for research activity was investigated to measure burden-adjusted research intensity for 52 infectious diseases at global and country levels. There was significantly low research intensity for paratyphoid fever and high intensity for influenza, HIV/acquired immunodeficiency syndrome, hepatitis C, and tuberculosis considering their disease burden. We identified the infectious diseases that have received the most attention from researchers and those that have been relatively disregarded. Interestingly, not all so-called neglected tropical diseases were subject to low burden-adjusted research intensity. Analysis of the intensity of infectious disease research at a country level revealed characteristic patterns. These findings provided a basis for further discussion of the more appropriate allocation of resources for research into infectious diseases.

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13

Stephen, Craig, John Berezowski, and Vikram Misra. "Surprise is a Neglected Aspect of Emerging Infectious Disease." EcoHealth 12, no. 2 (December 12, 2014): 208–11. http://dx.doi.org/10.1007/s10393-014-1001-4.

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14

Vuitika, Larissa, Wasim A. Prates-Syed, Jaqueline Dinis Queiros Silva, Karin P. Crema, Nelson Côrtes, Aline Lira, Julia Beatriz Menuci Lima, et al. "Vaccines against Emerging and Neglected Infectious Diseases: An Overview." Vaccines 10, no. 9 (August 25, 2022): 1385. http://dx.doi.org/10.3390/vaccines10091385.

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Neglected Tropical Diseases (NTDs) are a group of diseases that are highly prevalent in tropical and subtropical regions, and closely associated with poverty and marginalized populations. Infectious diseases affect over 1.6 billion people annually, and vaccines are the best prophylactic tool against them. Along with NTDs, emerging and reemerging infectious diseases also threaten global public health, as they can unpredictably result in pandemics. The recent advances in vaccinology allowed the development and licensing of new vaccine platforms that can target and prevent these diseases. In this work, we discuss the advances in vaccinology and some of the difficulties found in the vaccine development pipeline for selected NTDs and emerging and reemerging infectious diseases, including HIV, Dengue, Ebola, Chagas disease, malaria, leishmaniasis, zika, and chikungunya.

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15

Dent, Jennifer, Katy M. Graef, and Paddy Shivanand. "Open innovation to bolster research and development for neglected and emerging infectious diseases." Journal of Medicines Development Sciences 1, no. 1 (November 17, 2016): 46. http://dx.doi.org/10.18063/jmds.v1i1.119.

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Infections remain a significant cause of disease, disability, and death in developing countries. Unfortunately, many of these infections, including centuries-old neglected diseases such as malaria and newly emerging and re-emerging diseases such as Ebola virus disease (EVD), have limited products available to prevent, diagnose, and treat them. One barrier that hinders the development of these products is neglected and emerging disease experts’ limited access to the biopharmaceutical industry’s small molecules, technologies, and know-how. Conversely, the biopharmaceutical industry’s lack of attention to and expertise in these diseases impedes the development of much-needed products. Organisations are addressing these challenges by developing platforms through which disease experts can access industry’s knowledge and assets. Strategic partnerships are applying a synergistic approach to leverage respective strengths of academia and industry. The following article describes two open innovation platforms, the Pool for Open Innovation against Neglected Tropical Diseases (POINT) and WIPO Re:Search, and two strategic, cross-sector collaborative efforts to develop therapeutics for EVD.

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16

Dent, Jennifer, Katy M. Graef, and Paddy Shivanand. "Open innovation to bolster research and development for neglected and emerging infectious diseases." Journal of Medicines Development Sciences 1, no. 1 (November 17, 2016): 46. http://dx.doi.org/10.18063/jmds.2015.01.008.

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Infections remain a significant cause of disease, disability, and death in developing countries. Unfortunately, many of these infections, including centuries-old neglected diseases such as malaria and newly emerging and re-emerging diseases such as Ebola virus disease (EVD), have limited products available to prevent, diagnose, and treat them. One barrier that hinders the development of these products is neglected and emerging disease experts’ limited access to the biopharmaceutical industry’s small molecules, technologies, and know-how. Conversely, the biopharmaceutical industry’s lack of attention to and expertise in these diseases impedes the development of much-needed products. Organisations are addressing these challenges by developing platforms through which disease experts can access industry’s knowledge and assets. Strategic partnerships are applying a synergistic approach to leverage respective strengths of academia and industry. The following article describes two open innovation platforms, the Pool for Open Innovation against Neglected Tropical Diseases (POINT) and WIPO Re:Search, and two strategic, cross-sector collaborative efforts to develop therapeutics for EVD.

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17

Molyneux, David H. "“Neglected” diseases but unrecognised successes—challenges and opportunities for infectious disease control." Lancet 364, no. 9431 (July 2004): 380–83. http://dx.doi.org/10.1016/s0140-6736(04)16728-7.

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18

Kumanan, Thirunavukarasu, Vathulan Sujanitha, and Nadarajah Sreeharan. "Amoebic liver abscess: a neglected tropical disease." Lancet Infectious Diseases 20, no. 2 (February 2020): 160–62. http://dx.doi.org/10.1016/s1473-3099(19)30696-6.

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19

Jesudason, Timothy. "13th annual Neglected Tropical Disease NNN conference." Lancet Infectious Diseases 22, no. 11 (November 2022): 1543. http://dx.doi.org/10.1016/s1473-3099(22)00672-7.

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20

Lima Neto, Antonio S., Geziel S. Sousa, Osmar J. Nascimento, and Marcia C. Castro. "Chikungunya-attributable deaths: A neglected outcome of a neglected disease." PLOS Neglected Tropical Diseases 13, no. 9 (September 12, 2019): e0007575. http://dx.doi.org/10.1371/journal.pntd.0007575.

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21

Craig, Philip S., Christine M. Budke, Peter M. Schantz, Tiaoying Li, Jiamin Qiu, Yurong Yang, Eberhard Zeyhle, Michael T. Rogan, and Akira Ito. "Human Echinococcosis: A Neglected Disease?" Tropical Medicine and Health 35, no. 4 (2007): 283–92. http://dx.doi.org/10.2149/tmh.35.283.

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22

Marlina, Leni. "HUBUNGAN INFEKSI SOIL TRANSMITTED HELMINTHS DENGAN KADAR Hb PADA ANAK SEKOLAH DASAR DI DESA NELAYAN KOTA BENGKULU." JURNAL MEDIA KESEHATAN 5, no. 2 (November 12, 2018): 127–32. http://dx.doi.org/10.33088/jmk.v5i2.188.

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helminthiasis is a disease caused by a worm or helminth. Worm disease is a neglected infectious diseases / Neglected Infectious Disease (NIDS), which can lead to declining health, nutrition, intelligence and productivity. Factors that could cause the high incidence of worm disease is sanitation, hygiene, education level, socio-economic, knowledge, attitudes, behavior and geographical conditions. This study aimed to determine the relationship Soil transmitted helminth infections with Hb levels in elementary school children in the fishing village town of Bengkulu. This study was a cross sectional analytic. Subjects were four primary school pupils in Desa Nelayan of Bengkulu. Large sample of 185 samples. Sampling with simple random sampling technique. Examination of faeces by direct methods. Analysis of the samples by using the t test. The result showed no significant association with Hb STH infection (p = 0.09), no significant relationship with personal hygiene STH infection (p = 0.89), no significant association with the school environment sanitation STH infections (p = 0.34) and no significant relationship with the environmental sanitation STH infection (p = 0.70) in the elementary school children in Desa Nelayan of Bengkulu. The school have to provide counseling so that maintain the health of the prevention efforts that can reduce STH infections in elementary school children.

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23

Marlina, Leni. "HUBUNGAN INFEKSI SOIL TRANSMITTED HELMINTHS DENGAN KADAR Hb PADA ANAK SEKOLAH DASAR DI DESA NELAYAN KOTA BENGKULU." JURNAL MEDIA KESEHATAN 5, no. 2 (November 12, 2018): 127–32. http://dx.doi.org/10.33088/jmk.v5i2.188.

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helminthiasis is a disease caused by a worm or helminth. Worm disease is a neglected infectious diseases / Neglected Infectious Disease (NIDS), which can lead to declining health, nutrition, intelligence and productivity. Factors that could cause the high incidence of worm disease is sanitation, hygiene, education level, socio-economic, knowledge, attitudes, behavior and geographical conditions. This study aimed to determine the relationship Soil transmitted helminth infections with Hb levels in elementary school children in the fishing village town of Bengkulu. This study was a cross sectional analytic. Subjects were four primary school pupils in Desa Nelayan of Bengkulu. Large sample of 185 samples. Sampling with simple random sampling technique. Examination of faeces by direct methods. Analysis of the samples by using the t test. The result showed no significant association with Hb STH infection (p = 0.09), no significant relationship with personal hygiene STH infection (p = 0.89), no significant association with the school environment sanitation STH infections (p = 0.34) and no significant relationship with the environmental sanitation STH infection (p = 0.70) in the elementary school children in Desa Nelayan of Bengkulu. The school have to provide counseling so that maintain the health of the prevention efforts that can reduce STH infections in elementary school children.

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24

Ung, Lawson, Nisha R. Acharya, Tushar Agarwal, Eduardo C. Alfonso, Bhupesh Bagga, Paulo JM Bispo, Matthew J. Burton, et al. "Infectious corneal ulceration: a proposal for neglected tropical disease status." Bulletin of the World Health Organization 97, no. 12 (November 1, 2019): 854–56. http://dx.doi.org/10.2471/blt.19.232660.

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25

Murray, Kristy O., Rebecca S. B. Fischer, Denis Chavarria, Christiane Duttmann, Melissa N. Garcia, Rodion Gorchakov, Peter J. Hotez, et al. "Mesoamerican nephropathy: a neglected tropical disease with an infectious etiology?" Microbes and Infection 17, no. 10 (October 2015): 671–75. http://dx.doi.org/10.1016/j.micinf.2015.08.005.

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26

Bronstein, A. M., Yu V. Lobzin, S. S. Kozlov, and A. B. Birg. "From primitive jungle medicine to tropical medicine: history of progress and current challenges in the tropical disease control." Journal Infectology 14, no. 2 (July 12, 2022): 5–13. http://dx.doi.org/10.22625/2072-6732-2022-14-2-5-13.

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Neglected tropical diseases (NTDs) have long been overlooked in the global health agenda. The article is intended to generate information in consideration of the history of colonization of tropical countries with a special focus on tropical diseases especially common in the army during colonial wars and throughout the colonial era. Extreme poverty and warm tropical climates are the two most potent forces promoting the spread of neglected tropical diseases. European colonial doctors made valuable contribution towards understanding them and discovery these diseases. Large outbreaks of infectious and tropical diseases occurred in the Army throughout the colonial era, strongly influenced the formation of the Army Medical Services including provision for teaching and research. Subsequent improvements in prevention, diagnosis and treatment reduced the mortality from tropical diseases. Now in an era of “globalized” environment of interdependent trade, travel, migration, and international economic markets, many factors play an important role in the rise, emergence, and reemergence of tropical infectious disease, which necessitates a coordinated, global response. Many of the emerging and reemerging infectious diseases are also “neglected,” meaning they impact the world’s poorest and lack adequate funding and innovation for prevention and treatment, with some not adequately identified or studied. Although progress has been made in the management of neglected disease, there remains much work to be done. During the coming decade the global response will be able to further build on today’s successes, align with the new global health and development frameworks.

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27

Aronoff, David M. "The first year of Infectious Disease Reports." Infectious Disease Reports 2, no. 2 (November 3, 2010): 16. http://dx.doi.org/10.4081/idr.2010.2138.

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It is exciting to note that within our first year IDR has published original studies, review articles, and case reports from Australia, Brazil, Cuba, Italy, Thailand, Tunisia, Saudi Arabia, Uganda, the UK, and the USA. The first two volumes of IDR have touched upon major problems in our field, including HIV, influenza, Clostridium difficile, neglected tropical diseases, and infections in transplant recipients.

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28

RR, Kasarla. "Brucella Infection: A Major Public Health Concern." Open Access Journal of Microbiology & Biotechnology 7, no. 2 (April 6, 2022): 1–3. http://dx.doi.org/10.23880/oajmb-16000227.

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Zoonotic infectious diseases are common in societies where poverty is widespread, and where people rely on animals for their livelihood, that severely hinders livestock productivity and human health worldwide, particularly in the developing world and have been historically neglected by decision makers over the decades. WHO has identified a subgroup of eight endemic or neglected zoonotic diseasesanthrax, bovine tuberculosis, brucellosis, Taenia solium cysticercosis, hydatid disease, leishmaniasis, rabies, and human African trypanosomiasis.

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29

Montgomery, Susan P., Michelle C. Starr, Paul T. Cantey, Morven S. Edwards, and Sheba K. Meymandi. "Neglected Parasitic Infections in the United States: Chagas Disease." American Journal of Tropical Medicine and Hygiene 90, no. 5 (May 7, 2014): 814–18. http://dx.doi.org/10.4269/ajtmh.13-0726.

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30

Mangal, Shweta. "Adult Immunization: A Neglected Domain." Healthline 13, no. 4 (December 31, 2022): 283–86. http://dx.doi.org/10.51957/healthline_463_2022.

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“Long Life for All” being the theme for this year’s World Immunization Week 2022, celebrated annually in the last week of April (24 to 30th April) aims to unite people on the idea that vaccines make it possible for people to pursue their dreams, protect loved ones and live a long and healthy life. It aims to highlight the collective action needed and to promote the use of vaccines to protect people of all ages against disease. Immunization is one of the world’s most successful and cost-effective health interventions available to avert vaccine preventable diseases and deaths. Since at least the 1400s, people have looked for ways to protect themselves against infectious disease. From the practice of “variolation” in the 15th century to today’s mRNA vaccines, immunization has a long history.For over two centuries, vaccines have helped in keeping people healthy starting from the first vaccine that was developed to provide protection against smallpox to the latest ones that are being used to prevent COVID-19.

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31

Cabañes, F. Javier. "Epizootic lymphangitis: A neglected disease of working equids." Revista Iberoamericana de Micología 39, no. 1 (January 2022): 4–5. http://dx.doi.org/10.1016/j.riam.2021.11.001.

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32

Chaara, Dhekra, Najoua Haouas, Jean Pierre Dedet, Hamouda Babba, and Francine Pratlong. "Leishmaniases in Maghreb: An endemic neglected disease." Acta Tropica 132 (April 2014): 80–93. http://dx.doi.org/10.1016/j.actatropica.2013.12.018.

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33

Nash, Theodore E., Siddhartha Mahanty, and Hector H. Garcia. "Neurocysticercosis—More Than a Neglected Disease." PLoS Neglected Tropical Diseases 7, no. 4 (April 25, 2013): e1964. http://dx.doi.org/10.1371/journal.pntd.0001964.

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34

Hotez, Peter J., Serap Aksoy, Paul J. Brindley, and Shaden Kamhawi. "What constitutes a neglected tropical disease?" PLOS Neglected Tropical Diseases 14, no. 1 (January 30, 2020): e0008001. http://dx.doi.org/10.1371/journal.pntd.0008001.

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35

Murray, Henry W. "Progress in the treatment of a neglected infectious disease: visceral leishmaniasis." Expert Review of Anti-infective Therapy 2, no. 2 (April 2004): 279–92. http://dx.doi.org/10.1586/14787210.2.2.279.

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36

Taylor, Rosie. "New landscape for neglected disease drug R&D." Lancet Infectious Diseases 5, no. 11 (November 2005): 674–75. http://dx.doi.org/10.1016/s1473-3099(05)70252-8.

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37

Senior, Kathryn. "Calls for a financing shake up for neglected disease." Lancet Infectious Diseases 9, no. 1 (January 2009): 12. http://dx.doi.org/10.1016/s1473-3099(08)70295-0.

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38

Pischke, Sven. "Hepatitis E: the first book about a neglected disease." Lancet Infectious Diseases 18, no. 1 (January 2018): 36. http://dx.doi.org/10.1016/s1473-3099(17)30721-1.

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39

Tarleton, Rick L., Ricardo E. Gürtler, Julio A. Urbina, Janine Ramsey, and Rodolfo Viotti. "Chagas Disease and the London Declaration on Neglected Tropical Diseases." PLoS Neglected Tropical Diseases 8, no. 10 (October 9, 2014): e3219. http://dx.doi.org/10.1371/journal.pntd.0003219.

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40

Hamm, Logan, Amira Gee, and A. Swarnapali De Silva Indrasekara. "Recent Advancement in the Surface-Enhanced Raman Spectroscopy-Based Biosensors for Infectious Disease Diagnosis." Applied Sciences 9, no. 7 (April 6, 2019): 1448. http://dx.doi.org/10.3390/app9071448.

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Diagnosis is the key component in disease elimination to improve global health. However, there is a tremendous need for diagnostic innovation for neglected tropical diseases that largely consist of mosquito-borne infections and bacterial infections. Early diagnosis of these infectious diseases is critical but challenging because the biomarkers are present at low concentrations, demanding bioanalytical techniques that can deliver high sensitivity with ensured specificity. Owing to the plasmonic nanomaterials-enabled high detection sensitivities, even up to single molecules, surface-enhanced Raman spectroscopy (SERS) has gained attention as an optical analytical tool for early disease biomarker detection. In this mini-review, we highlight the SERS-based assay development tailored to detect key types of biomarkers for mosquito-borne and bacterial infections. We discuss in detail the variations of SERS-based techniques that have developed to afford qualitative and quantitative disease biomarker detection in a more accurate, affordable, and field-transferable manner. Current and emerging challenges in the advancement of SERS-based technologies from the proof-of-concept phase to the point-of-care phase are also briefly discussed.

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41

Sack, Alexandra, Ann Cullinane, Ulziimaa Daramragchaa, Maitsetseg Chuluunbaatar, Battsetseg Gonchigoo, and Gregory C. Gray. "Equine Influenza Virus—A Neglected, Reemergent Disease Threat." Emerging Infectious Diseases 25, no. 6 (June 2019): 1185–91. http://dx.doi.org/10.3201/eid2506.161846.

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Ojezele, Matthew Obaineh, Joseph Mordi, and Emmanuel Adesola Adedapo. "Drug repurposing: cost effectiveness and impact on emerging and neglected diseases." Journal of the Cameroon Academy of Sciences 16, no. 1 (October 13, 2020): 3–17. http://dx.doi.org/10.4314/jcas.v16i1.1.

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Historically, pressure on nature brought about by ever-increasing human pollution and technological advancement culminate in emergence and re- emergence of infectious and non-infectious diseases; necessitating medications and drug discovery and development. The emergence of resistantmicroorganisms and the emergence of new infections disease conditions necessitate the production of entirely new drugs or modification of the existing ones to increase their efficacy. The development of novel medications is a very long and expensive process. There is a significant decrease observed in the number of new drugs approved for clinical use in recent years showing inconsistency in the face of scientific advances and research and development investment. Regardless of high investment and enormous contributions, very few molecules showed promising results. However, finding novel indications for existing drugs can be a useful method of reducing the developmental cycle of drugs. Repositioning (also called repurposing) has been described as the practice of developing new therapeutic uses for drugs, abandoned or drugs in development process, other than the initially intended or approved uses, except for the circumstances in which the novel use is comparable to the original indication with dissimilar pharmacological targets. This review aimed at looking into some of the available methods in drug repurposing. Key words: Drug discovery; Drug repurposing; Machine learning; Neglected Tropical diseases; Orphan drugs

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Fahal, Ahmed H. "Mycetoma: the journey from neglect to recognition as a neglected tropical disease." Transactions of The Royal Society of Tropical Medicine and Hygiene 115, no. 4 (February 4, 2021): 292–94. http://dx.doi.org/10.1093/trstmh/traa195.

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Abstract Mycetoma recently had gained international attention and conscious awareness after its inclusion under the WHO/NTD list in 2016. The journey to achieve that was both long, challenging as well as it was exciting and hard. In this article, the milestones and various events that took place in this journey were documented and highlighted.

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Farley, Elise, Cono Ariti, Mohana Amirtharajah, Charity Kamu, Bukola Oluyide, Muhammad Shoaib, Shafiu Isah, et al. "Noma, a neglected disease: A viewpoint article." PLOS Neglected Tropical Diseases 15, no. 6 (June 17, 2021): e0009437. http://dx.doi.org/10.1371/journal.pntd.0009437.

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Kwizera, Richard, Felix Bongomin, David B. Meya, David W. Denning, Ahmed H. Fahal, and Robert Lukande. "Mycetoma in Uganda: A neglected tropical disease." PLOS Neglected Tropical Diseases 14, no. 4 (April 29, 2020): e0008240. http://dx.doi.org/10.1371/journal.pntd.0008240.

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Savaj, Pratik, Tushar Shaw, Frenil C. Munim, and Chiranjay Mukhopadhyay. "Melioidosis in Gujarat: a neglected tropical disease." Tropical Doctor 50, no. 4 (June 12, 2020): 373–75. http://dx.doi.org/10.1177/0049475520928219.

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Gomes, Andréia Patrícia, Diana Marques Gazola, Luciene Muniz Braga, Oswaldo Jesus Rodrigues Da Motta, and Jorge Luiz Dutra Gazineo. "Leptospirosis: An Update - Part 1 Of 2: Etiology, Ecology, Epidemiology, Prophylaxis And Contro / Leptospirose: Uma actualização - Parte 1 De 2: Etiologia, Ecologia, Epidemiologia, Profilaxia e Controlo." Brazilian Journal of Health Review 5, no. 3 (June 15, 2022): 11361–72. http://dx.doi.org/10.34119/bjhrv5n3-281.

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Leptospirosis belongs to the category of neglected infectious diseases and, due to its great epidemic potential, its local distribution in tropical regions is of extreme importance. It is a worldwide public health problem, known for the emergence and reappearance of the disease, lack of sanitary conditions and abandonment of the disease. Human infections usually occur after skin contact with soil and/or water contaminated by the urine of chronically infected mammals. The clinical manifestations of the disease range from mild fever, chills and flu-like symptoms to acute forms of the disease. Based on these brief considerations, this article - part 1 of 2 - aims to discuss the biological, ecoepidemiological, prophylactic and control aspects of leptospirosis in Brazil.

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Hoarau, Axel O. G., Patrick Mavingui, and Camille Lebarbenchon. "Coinfections in wildlife: Focus on a neglected aspect of infectious disease epidemiology." PLOS Pathogens 16, no. 9 (September 3, 2020): e1008790. http://dx.doi.org/10.1371/journal.ppat.1008790.

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de Macedo, Priscila Marques, Rodrigo Almeida-Paes, Dayvison Francis Saraiva Freitas, Paula Marsillac, Ana Paola de Oliveira, Flavia Antelo Saez, Bodo Wanke, and Antonio Carlos Francesconi do Valle. "Abdominal Cystic-Like Lesion as a Rare Complication of Neglected Infectious Disease." PLOS Neglected Tropical Diseases 10, no. 9 (September 29, 2016): e0004947. http://dx.doi.org/10.1371/journal.pntd.0004947.

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Yotsu, Rie R., L. Claire Fuller, Michele E. Murdoch, Wim H. van Brakel, Chandrakant Revankar, Mahoutondji Yves Thierry Barogui, Jose Antonio Ruiz Postigo, Daniel Argaw Dagne, Kingsley Asiedu, and Roderick J. Hay. "A global call for action to tackle skin-related neglected tropical diseases (skin NTDs) through integration: An ambitious step change." PLOS Neglected Tropical Diseases 17, no. 6 (June 15, 2023): e0011357. http://dx.doi.org/10.1371/journal.pntd.0011357.

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On 8 June 2022, the World Health Organization (WHO) released pivotal guidance, “Ending the neglect to attain the Sustainable Development Goals: A strategic framework for integrated control and management of skin-related neglected tropical diseases.” Skin-related neglected tropical diseases, or skin NTDs, comprise a group of NTDs that produce signs and symptoms on the skin and include at least 9 diseases or disease groups. Moving away from disease-specific approaches, it is anticipated that synergies will be identified and integrated building on this shared feature, where possible, to achieve a greater health impact. This paper intends to draw attention to the prospects created by this scheme. The framework is a key basis for a proposal produced by WHO dedicated to skin NTD integration and describes the practical opportunities for this evolving strategy. It underlines the wider health benefits that will follow, thus working towards Universal Health Coverage and skin health for all.

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