Готові списки джерел за темами / Natural product-inspired libraries

Добірка наукової літератури з теми "Natural product-inspired libraries"

Автор: Grafiati
Опубліковано: 10 грудня 2022
Оновлено: 29 січня 2023

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Статті в журналах з теми "Natural product-inspired libraries"

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Chauhan, Jyoti, Tania Luthra, Rambabu Gundla, Antonio Ferraro, Ulrike Holzgrabe, and Subhabrata Sen. "A diversity oriented synthesis of natural product inspired molecular libraries." Organic & Biomolecular Chemistry 15, no. 43 (2017): 9108–20. http://dx.doi.org/10.1039/c7ob02230a.

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Jeong, Yong-Chul, Muhammad Anwar, Zsolt Bikadi, Eszter Hazai, and Mark G. Moloney. "Natural product inspired antibacterial tetramic acid libraries with dual enzyme inhibition." Chem. Sci. 4, no. 3 (2013): 1008–15. http://dx.doi.org/10.1039/c2sc21713a.

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Cremosnik, Gregor S., Jie Liu, and Herbert Waldmann. "Guided by evolution: from biology oriented synthesis to pseudo natural products." Natural Product Reports 37, no. 11 (2020): 1497–510. http://dx.doi.org/10.1039/d0np00015a.

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Sigauke, Lester T., Özlem Taştan Bishop, and Kevin A. Lobb. "Introducing DerivatizeME and its Application in the Augmentation of a Natural Product Library." Journal of Computational Biophysics and Chemistry 20, no. 03 (March 20, 2021): 233–50. http://dx.doi.org/10.1142/s2737416521500101.

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Анотація:
The large chemical space universe can be traversed by screening libraries of compounds that possess novel medicinally relevant chemistries, properties and complexity criteria. These libraries can be populated with the use of exhaustive, de novo approaches or inspired, combinatorial approaches. By assuming that natural products within screening libraries may be classified as a source of feedstock for populating virtual libraries, they can act as scaffolds upon which exhaustive approaches may be used in exploring chemical space. In order to achieve this, we have built DerivatizeME as a tool that enumerates derivatives of query compounds in order to evaluate their relevance for further assessment and development. This technique was applied to natural products present in the South African natural compound database (SANCDB). By expanding the chemical space of SANCDB compounds through the generation of SANCDB derivatives, we were able to graduate some natural products that were in undesirable regions of medicinally relevant chemical space, to acceptable regions of this chemical space. These modified scaffolds are available for further development, testing and evaluation in a manner similar to natural product driven focused libraries. The natural product parent is used, through its derivatives, instead of being discarded from screening protocols. This approach has the potential to enhance the efficiency of the natural product library in providing successful hits, amplifying the potential that they possess to access both novel bioactives and privileged scaffolds which may have otherwise been overlooked.
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Arya, P., S. Quevillon, R. Joseph, C. Q. Wei, Z. Gan, M. Parisien, E. Sesmilo, et al. "Toward the library generation of natural product-like polycyclic derivatives by stereocontrolled diversity-oriented synthesis." Pure and Applied Chemistry 77, no. 1 (January 1, 2005): 163–78. http://dx.doi.org/10.1351/pac200577010163.

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Due to the growing interest in small molecules that could help in understanding protein–protein interactions based on signal transduction, the demand for the generation of small-molecule libraries that are inspired by bioactive natural products has grown significantly. Many of these pathways are highly complex and present tremendous challenges with the use of classical tools. A rapid access to natural product-like small molecules having structural complexity and diversity is crucial for systematically dissecting the functions of complex protein networking and understanding cell signaling pathways. The complex nature, the three-dimensional architecture, and the number of protein binding functional groups presented in three-dimensional arrays are some of the attractive features to incorporate in small-molecule chemical probes to be used as modulators of protein function.
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Ito, Kenichiro, Toby Passioura, and Hiroaki Suga. "Technologies for the Synthesis of mRNA-Encoding Libraries and Discovery of Bioactive Natural Product-Inspired Non-Traditional Macrocyclic Peptides." Molecules 18, no. 3 (March 18, 2013): 3502–28. http://dx.doi.org/10.3390/molecules18033502.

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Mazraati Tajabadi, Fatemeh, Rebecca H. Pouwer, Miaomiao Liu, Yousef Dashti, Marc R. Campitelli, Mariyam Murtaza, George D. Mellick, Stephen A. Wood, Ian D. Jenkins, and Ronald J. Quinn. "Design and Synthesis of Natural Product Inspired Libraries Based on the Three-Dimensional (3D) Cedrane Scaffold: Toward the Exploration of 3D Biological Space." Journal of Medicinal Chemistry 61, no. 15 (July 13, 2018): 6609–28. http://dx.doi.org/10.1021/acs.jmedchem.8b00194.

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Umeno, Daisuke, Alexander V. Tobias, and Frances H. Arnold. "Diversifying Carotenoid Biosynthetic Pathways by Directed Evolution." Microbiology and Molecular Biology Reviews 69, no. 1 (March 2005): 51–78. http://dx.doi.org/10.1128/mmbr.69.1.51-78.2005.

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Анотація:
SUMMARY Microorganisms and plants synthesize a diverse array of natural products, many of which have proven indispensable to human health and well-being. Although many thousands of these have been characterized, the space of possible natural products—those that could be made biosynthetically—remains largely unexplored. For decades, this space has largely been the domain of chemists, who have synthesized scores of natural product analogs and have found many with improved or novel functions. New natural products have also been made in recombinant organisms, via engineered biosynthetic pathways. Recently, methods inspired by natural evolution have begun to be applied to the search for new natural products. These methods force pathways to evolve in convenient laboratory organisms, where the products of new pathways can be identified and characterized in high-throughput screening programs. Carotenoid biosynthetic pathways have served as a convenient experimental system with which to demonstrate these ideas. Researchers have mixed, matched, and mutated carotenoid biosynthetic enzymes and screened libraries of these “evolved” pathways for the emergence of new carotenoid products. This has led to dozens of new pathway products not previously known to be made by the assembled enzymes. These new products include whole families of carotenoids built from backbones not found in nature. This review details the strategies and specific methods that have been employed to generate new carotenoid biosynthetic pathways in the laboratory. The potential application of laboratory evolution to other biosynthetic pathways is also discussed.
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Gu, Qiong, Xin Yan, and Jun Xu. "Drug Discovery Inspired by Mother Nature: Seeking Natural Biochemotypes and the Natural Assembly Rules of the Biochemome." Journal of Pharmacy & Pharmaceutical Sciences 16, no. 2 (August 2, 2013): 331. http://dx.doi.org/10.18433/j3c31s.

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Purpose. The Human Genome Project is producing a new biological ‘periodic table’, which defines all genes for making macromolecules (proteins, DNA, RNA, etc) and the relations between genes and their biological functions. We now need to consider whether to initiate a biochemome project aimed at discovering biochemistry’s ‘periodic table’, which would define all molecular parts for making small molecules (natural products) and the relations between the parts and their functions to regulate genes. By understanding the Biochemome, we might be able to design biofunctional molecules based upon a set of molecular parts for drug innovation. Methods. A number of algorithms for processing chemical structures are used to systematically derive chemoyls (natural building blocks) from a database of compounds identified in Traditional Chinese Medicine (TCM). The rules to combine chemoyls for biological activities are then deduced by mining an annotated TCM structure-activity database (ATCMD). Based upon the rules and the basic chemoyls, a chemical library can be biochemically profiled, virtual synthetic routes can be planned, and lead compounds can be identified for a specific drug target. Conclusions. The Biochemome is the complete set of molecular components (chemoyls) in an organism and Biochemomics studies the rules governing their assembly and their evolution, together with the relations between the Biochemome and drug targets. This approach provides a new paradigm for drug discovery that is based on a comprehensive knowledge of the synthetic origins of biochemical diversity, and helps to direct biomimetic syntheses aimed at assembling quasi-natural product libraries for drug screening. This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.
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Aggarwal, Meenu, Raman Singh, Priyanka Ahlawat, and Kuldeep Singh. "Bioactive Extracts: Strategies to generate Diversified Natural Product Like Libraries." Current Bioactive Compounds 18 (January 11, 2022). http://dx.doi.org/10.2174/1573407218666220111105443.

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Анотація:
Abstract: Natural products have stimulated chemists owing to their abundant structural diversity and complexity. Indeed, natural products have performed an essential role, particularly in the cure of cancerous and infectious diseases, thereby posing medicinal researchers with a scope of unexplored chemotypes for the innovation of new drugs. Fusion of chemical derivatization and combinatorial synthesis forms the basis of the concept of chemo diversification of plants. Diverse libraries of natural product analogs are constructed through existing biological and chemical approaches using unique schemes to expand natural product frameworks. This review aims to present several approaches employed to offer innovative opportunities to synthesize NP-inspired compound libraries. Reactive molecular fragments present in most natural products are chemically converted to chemically engineered extracts (CEEs) or semisynthetic compounds constituting distinct libraries. Bio-guided isolation for natural products required vital tools like reverse phase chromatography and bioautographic assays. Different established strategies from DTS, BIOS, CtD, FOS, FBDD to Late-stage diversification facilitate the expansion of molecules with physicochemical properties. In particular, fragment-like natural products with novel skeletons may be used as preliminary points for chemical biology and medicinal chemistry programs with great capacity. In this review, we sum up how NPs have proven fruitful for the novel methodologies responsible for the diversification of complex natural products; thereby, it is worthy of going over the upcoming integration of natural products with combinatorial chemistry.
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Дисертації з теми "Natural product-inspired libraries"

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Keasler, Eric. "Determination of selectivity and potential for drug resistance of novel antimalarial compounds from nature-inspired synthetic libraries." Honors in the Major Thesis, University of Central Florida, 2012. http://digital.library.ucf.edu/cdm/ref/collection/ETH/id/572.

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Анотація:
As malaria, caused by Plasmodium spp., continues to afflict millions of people worldwide, there is a dire need for the discovery of novel, inexpensive antimalarial drugs. Although there are effective drugs on the market, the consistent development of drug resistant species has decreased their efficacy, further emphasizing that novel therapeutic measures are urgently needed. Natural products provide the most diverse reservoir for the discovery of unique chemical scaffolds with the potential to effectively combat malarial infections, but, due to their complex structures, they often pose extreme challenges to medicinal chemists during pharmacokinetic optimization. In our laboratory we have performed unbiased, cell-based assays of numerous synthetic compounds from chemical libraries enriched with nature-like elements. This screening has led to the discovery of many original chemical scaffolds with promising antimalarial properties. In an attempt to further characterize these scaffolds, the most promising compounds were assayed in order to determine their cytotoxic effects on mammalian cells. In addition, the development of a drug resistant parasite line of Plasmodium falciparum to the most promising compound was done in order to determine the relative probability for parasite resistance development.
B.S.
Bachelors
Burnett School of Biomedical Sciences
Molecular and Microbiology
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Тези доповідей конференцій з теми "Natural product-inspired libraries"

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Radha Krishnan, SK, A. Salm, O. Danton, M. Hamburger, M. Leonti, and J. Gertsch. "Phyloactivity-based screening of ethnomedically inspired plant extract libraries against Trypanosoma cruzi and Chagas disease." In 67th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA) in cooperation with the French Society of Pharmacognosy AFERP. © Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-3399656.

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