Дисертації з теми "Nanoparticle treatment"
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Fisusi, F. A. "Nanoparticle based strategies for the treatment of glioblastoma." Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1456357/.
Повний текст джерелаWallat, Jaqueline Diane. "Fluorous Nanoparticle Platform for Cancer Imaging and Treatment." Case Western Reserve University School of Graduate Studies / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=case1513787381901888.
Повний текст джерелаPhelane, Lisebo. "Metal nanoparticle modified polysulfone membrane for water treatment." Thesis, University of the Western Cape, 2013. http://hdl.handle.net/11394/4480.
Повний текст джерелаMembrane separation processes have been widely applied in the treatment of wastewater with polysulfone (PSF) polymer membrane being the most frequently used in ultrafiltration of wastewater due to its chemical and structural stability and mechanical robustness. The disadvantage to these membranes is their hydrophobicity which leads to membrane fouling caused by organic pollutants in water. Many studies have been conducted to increase the hydrophilic properties of the polysulfone membrane surface. Most recently metal oxide nanoparticles have been introduced to the polymer matrix in order to reduce membrane fouling and increase its hydrophilicity with measurable success. Natural organic matters are the one of the major fouling agents during ultrafiltration, reverse osmosis and microfiltration. Two organic acids (Tannic Acid and Alginic Acid) were selected to test the fouling behaviour of nanometallic synthesised polysulfone membranes. For this study, polysulfone casting suspension was prepared by dissolving polysulfone beads in N,N-dimethly acetamide. Three metallic nanoparticles of Silver, Cobalt and Nickel were selected to improve the hydrophilicity of the polysulfone membrane. The metal nanoparticles were prepared using the chemical reduction method. Cobalt nanoparticles were synthesized by dissolving the cobalt chloride salt in deionized water and reduced with sodium borohydride at room temperature. The nickel chloride salt was dissolved in ethanol and reduced with sodium borohydride under magnetic stirrer. Silver nanoparticles were prepared by dissolving the silver nitrate in deionised water and heated to boil, the sodium citrate was added to reduced the silver nitrate. These nanoparticles were then integrated into the polysulfone polymer matrix to form the metal nanoparticle polysulfone nanocomposites. This study focused on four prepared polysulfone nanocomposite membrane; 1 unmodified polysulfone (PSF), 2 polysulfone modified with cobalt nanoparticles (PSF/Co), 3 polysulfone modified with nickel nanoparticles (PSF/Ni) and 4 polysulfone modified with silver nanoparticles (PSF/Ag).
Peters, David Thomas. "Targeting atherosclerosis nanoparticle delivery for diagnosis and treatment /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2009. http://wwwlib.umi.com/cr/ucsd/fullcit?p3339266.
Повний текст джерелаTitle from first page of PDF file (viewed February 10, 2009). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references.
Restis, Eva Marie. "Development of Drug Loaded Nanoparticles for Treatment of Mycobacterium avium Infection." Diss., Virginia Tech, 2014. http://hdl.handle.net/10919/52565.
Повний текст джерелаPh. D.
Andersson, Mikael. "Modeling and characterization of magnetic nanoparticles intended for cancer treatment." Thesis, Uppsala universitet, Fasta tillståndets fysik, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-199055.
Повний текст джерелаWu, Xingchen. "Multiple sclerosis : MRI diagnosis, potential treatment and future potential for nanoparticle applications /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-515-1/.
Повний текст джерелаLin, Kevin (Kevin Yu-Ming). "Nanoparticle systems that exploit host biology for diagnosis and treatment of disease." Thesis, Massachusetts Institute of Technology, 2014. http://hdl.handle.net/1721.1/98337.
Повний текст джерелаCataloged from PDF version of thesis.
Includes bibliographical references (pages 131-151).
Over the past 30 years, advances in nanotechnology have generated a multitude of nanostructures exhibiting a breadth of physical, chemical, and biological properties that have tremendous potential to improve the detection and treatment of disease. Despite this progress, biomedical nanotechnologies have yet to approach the same level of complexity as biological systems, which produce higher-order functions through coordinated interactions between multiple nanoscale components. This thesis aims to explore the potential of nanoparticles to interface with the host biology to perform systems-level applications that benefit disease sensing and treatment. First, we engineered nanoparticles to sense dysregulated protease activity associated with thrombosis and generate reporters that can be noninvasively quantified in the urine. These nanoparticles exploit the vascular transport of the circulatory system and the size filtration function of the renal system to emit reporters into the urine following proteolytic cleavage events. The reporter levels in the urine differentiate between healthy and thrombotic states and correlate with clot burden in a mouse model of pulmonary embolism. Next, we developed nanoparticles that homeostatically regulate the biological cascade responsible for haemostasis to prevent the aberrant formation of clots. These nanoparticles form a negative feedback loop with thrombin, a key enzyme in the coagulation cascade, to regulate their release of the anticoagulant heparin. In mice, they inhibited the formation of pulmonary embolisms without an associated increase in bleeding, the primary side-effect of antithrombotic therapy in the clinic. Finally, we investigated a two-component system whereby the first therapeutic entity induces the upregulation a molecular signal within a malignant environment to amplify the local recruitment of a secondary population of targeted nanoparticles. Here, the interaction between the initial therapeutic and the targeted nanoparticles occurred indirectly through a biological stress pathway. This cooperative targeting system delivered up to five-fold higher nanoparticle doses to tumors than non-cooperative controls, leading to delayed tumor growth and improved survival in mice. Together, these systems highlight the potential for interactive nanoparticle systems to perform highly complex functions in vivo by leveraging and modulating the host biology. In contrast to the current strategy of injecting large populations of nanoparticles that carry out identical, pre-defined tasks with little to no feedback from the in vivo environment, this work supports the construction of nanoparticle systems that leverage both synthetic and endogenous components to produce emergent behaviors for enhancing diagnostics and therapeutics.
by Kevin Lin.
Sc. D.
Uppalapati, Lakshmi. "Peptides as therapeutics and active gene delivery vehicles for cancer treatment." Diss., Kansas State University, 2015. http://hdl.handle.net/2097/35231.
Повний текст джерелаDepartment of Agronomy
Masaaki Tamura
Over the years proteins/peptides have evolved as promising therapeutic agents in the treatment of cancer. Considering the advantages of peptides such as their small size, ease of synthesis, tumor-penetrating ability and bio-compatibility, present report discusses proof of concept for 1. C1B5 peptide of protein kinase Cγ and a low dose of gemcitabine combination treatment for peritoneally disseminated pancreatic cancer and 2. dTAT peptide nanoparticles mediated gene (angiotensin II type 2 receptor gene) therapy for lung cancer. 1. A significant reduction in intraperitoneally (IP) transplanted pancreatic carcinoma growth was demonstrated with C1B5 peptide and gemcitabine co-treatment in an immunocompetent mouse model. Increased number of Granzyme B positive cells was observed in treated mice ascites, suggesting the involvement of immune response in tumor attenuation. The strong effect observed in combination treatment might be because of increase in lymphocyte recruitment by gemcitabine followed by C1B5 peptide mediated CD8+ T-cells or NK cells activation apart from direct cancer cell apoptosis. 2. To test dTAT peptide nanoparticles (dTAT NPs) mediated therapeutic gene delivery, luciferase reporter gene containing dTAT nanoparticles were synthesized (dTAT/pLUC/Ca2+). Synthesis conditions for nanoparticles were optimized based on dTAT/pLUC/Ca2+ nanoparticles transfection efficiency. With the optimized conditions, dTAT NPs containing AT2R, TRAIL or miR-34a pDNA (dTAT/pAT2R, dTAT/TRAIL or dTAT/miR- 34a) were synthesized. Therapeutic potential of these NPs was analyzed in lung adenocarcinoma containing mice by administering them intravenously (IV) or/and intratracheally (IV). Combination treatment with the IV injection of the new dTAT/pAT2R/Ca2+ formulation and the IT injection of the original dTAT/pAT2R/Ca2+ formulation is effective in attenuation of developed human bronchioloalveolar carcinoma in the SCID mouse lungs. Findings from the above mentioned studies have vital clinical relevance as it implies that peptides alone or when used as gene delivery systems may prove to be beneficial in the treatment of various stages of cancer.
Seyedi, Seyed Mojtaba. "Engineered iron oxide nanoparticle-polymer composites for the removal of dissolved arsenic and antimony." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2017. https://ro.ecu.edu.au/theses/2038.
Повний текст джерелаManohar, Nivedh Harshan. "Quantitative imaging of gold nanoparticle distribution for preclinical studies of gold nanoparticle-aided radiation therapy." Diss., Georgia Institute of Technology, 2015. http://hdl.handle.net/1853/54877.
Повний текст джерелаSun, Lin. "Penetration evaluation and PLGA nanoparticle development of curcumin for topical delivery to treat psoriasis." Thesis, University of Macau, 2017. http://umaclib3.umac.mo/record=b3690807.
Повний текст джерелаZibin, Hai. "Modification of Titania with Gold-Copper Bimetallic Nanoparticles and Preparation of Copper-Based Photocatalysts : Application in Water Treatment." Phd thesis, Université Paris Sud - Paris XI, 2013. http://tel.archives-ouvertes.fr/tel-00926757.
Повний текст джерелаBielecki, Peter. "Advanced Mesoporous Silica Nanoparticles for the Treatment of Brain Tumors." Case Western Reserve University School of Graduate Studies / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=case159558503832021.
Повний текст джерелаKnapp, Christopher M. "Engineering siRNA Lipid Nanoparticles for the Treatment of Mantle Cell Lymphoma." Research Showcase @ CMU, 2017. http://repository.cmu.edu/dissertations/886.
Повний текст джерелаAbedin, Farhana. "Magnetic and albumin targeted drug delivery for breast cancer treatment." Thesis, Wichita State University, 2011. http://hdl.handle.net/10057/5054.
Повний текст джерелаThesis (M.S.)--Wichita State University, College of Engineering, Dept. of Mechanical Engineering.
Stigliano, Robert Vincent. "Development and validation of a treatment planning model for magnetic nanoparticle hyperthermia cancer therapy." Thesis, Dartmouth College, 2014. http://pqdtopen.proquest.com/#viewpdf?dispub=1566731.
Повний текст джерелаThe use of magnetic nanoparticles (mNPs) to induce local hyperthermia has been emerging in recent years as a promising cancer therapy, in both a stand-alone and combination treatment setting, including surgery radiation and chemotherapy. The mNP solution can be injected either directly into the tumor, or administered intravenously. Studies have shown that some cancer cells associate with, internalize, and aggregate mNPs more preferentially than normal cells, with and without antibody targeting. Once the mNPs are delivered inside the cells, a low frequency (30-300kHz) alternating electromagnetic field is used to activate the mNPs. The nanoparticles absorb the applied field and provide localized heat generation at nano-micron scales.
Treatment planning models have been shown to improve treatment efficacy in radiation therapy by limiting normal tissue damage while maximizing dose to the tumor. To date, there does not exist a clinical treatment planning model for magnetic nanoparticle hyperthermia which is robust, validated, and commercially available. The focus of this research is on the development and experimental validation of a treatment planning model, consisting of a coupled electromagnetic and thermal model that predicts dynamic thermal distributions during treatment.
When allowed to incubate, the mNPs are often sequestered by cancer cells and packed into endosomes. The proximity of the mNPs has a strong influence on their ability to heat due to interparticle magnetic interaction effects. A model of mNP heating which takes into account the effects of magnetic interaction was developed, and validated against experimental data. An animal study in mice was conducted to determine the effects of mNP solution injection duration and PEGylation on macroscale mNP distribution within the tumor, in order to further inform the treatment planning model and future experimental technique. In clinical applications, a critical limiting factor for the maximum applied field is the heating caused by eddy currents, which are induced in the noncancerous tissue. Phantom studies were conducted to validate the ability of the model to accurately predict eddy current heating in the case of zero blood perfusion, and preliminary data was collected to show the validity of the model in live mice to incorporate blood perfusion.
Sagar, Vidya. "Magnetic Nanoparticle-based Targeted Drug Delivery for Treatment of Neuro-AIDS and Drug Addiction." FIU Digital Commons, 2013. http://digitalcommons.fiu.edu/etd/909.
Повний текст джерелаЗленко, Віталій Олександрович, Виталий Александрович Зленко, Vitalii Oleksandrovych Zlenko, Максим Геннадійович Демиденко, Максим Геннадьевич Демиденко, Maksym Hennadiiovych Demydenko, Сергій Іванович Проценко, Сергей Иванович Проценко, and Serhii Ivanovych Protsenko. "Magneto-optical Studying of Magnetic Nanoparticle Arrays, Obtained by Thin Metal Films Thermal Treatment." Thesis, Sumy State University, 2015. http://essuir.sumdu.edu.ua/handle/123456789/40953.
Повний текст джерелаHE, PENG. "DEPOSITION OF EXTREMELY THIN FUNCTIONAL FILMS ON NANOPARTICLE/NANOTUBE SURFACES BY A PLASMA TREATMENT." University of Cincinnati / OhioLINK, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1068676591.
Повний текст джерелаWen, Wucheng. "Development and Evaluation of Nano-herbal Therapy for Metastatic Breast Cancer Treatment." Diss., Temple University Libraries, 2018. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/534260.
Повний текст джерелаPh.D.
Triptolide (TPL), a diterpenoid triepoxide that is extracted from a traditional Chinese herb called Tripterygium Wilfordii (also known as ‘Thunder God Vine’) has recently drawn increasing interests from pharmaceutical and biomedical researchers, especially in the aspect of its potential efficacy on multiple cancer treatment. TPL has shown significant growth and proliferation inhibition activities in a broad range of cancer cell types. Moreover, it has shown the inhibition of osteoclastogenesis by breast cancer bone metastasis. However, due to its limitation in toxicity, solubility and non-specific biodistribution, it is challenging for the application of TPL in clinical study. Besides, TPL can rapidly distribute in most vital organs and no evidences shown tissue accumulation of drug. It is indispensable to overcome those barriers and optimize the properties and performance of the promising drug molecule. Lipid-based nanocarriers such as nanostructured lipid carriers (NLC) have been extensively studied for delivery of poorly-water soluble drug compounds. They also have the potential to optimize the physicochemical properties of the drug and may enhance a targeted delivery of the drug to specific therapeutic site. Alendronate (Fosamax®), an FDA approved bisphosphonate drug for osteoporosis, osteogenesis imperfecta and several other bone diseases, has been used as a bone targeting decoration agent. Breast cancer cell line MDA-MB-231 and other type of cancer cell lines have been used to study the in vitro cytotoxicity of TPL and the carriers while MC3T3-E1 cell line was used for toxicity assessment. Rats have also been used to study the in vivo performance of the drug. After modifying and optimizing the formulation of the particle, the formulation had the ability to remain structurally and functionally stable when being in the bio-simulated media at 37 °C and in water at room temperature with high encapsulation efficiency. In vitro study illustrated that both TPL free drug (stock solution 10mg/mL dissolved in DMSO) and TPL nanoparticle without alendronate (TPL-NP) had similar cytotoxicity on MDA-MB-231 and some other type of cancer cell lines. The ALE decoration on the particle (ALE-NP-TPL) has enhanced the anti-cancer effect especially with breast cancer cell line. The in vivo study shows that after 24 hours of the dose injection at local bone site, the formulation and TPL can remained at the location without random distribution to other organs. TPL-NP has not only successfully optimized the physicochemical properties of the drug, but also shows great enhancement of therapeutic effect both in vitro and in vivo study.
Temple University--Theses
Lee, Kate Y. J. "Colloidal gold nanoparticles for cancer therapy: effects of particle size on treatment efficacy, toxicology, and biodistribution." Diss., Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/43640.
Повний текст джерелаShirkhani, Khojasteh. "Bioactivity of new AmB-PMA nanoparticle in prophylaxis and treatment of transplant-related invasive aspergillosis." Thesis, Imperial College London, 2014. http://hdl.handle.net/10044/1/24157.
Повний текст джерелаCover, Natasha Faith. "A Novel Device and Nanoparticle-Based Approach for Improving Diagnosis and Treatment of pelvic Inflammatory Disease." Scholar Commons, 2012. http://scholarcommons.usf.edu/etd/4020.
Повний текст джерелаPapa, Simonetta Giulia. "Characterization of a Nanoparticle Drug Delivery System for the Treatment of Inflammation in Spinal Cord Injury." Thesis, Open University, 2017. http://oro.open.ac.uk/48334/.
Повний текст джерелаMapukata, Sivuyisiwe. "Photocatalytic treatment of organic and inorganic water pollutants using zinc phthalocyanine-cobalt ferrite magnetic nanoparticle conjugates." Thesis, Rhodes University, 2019. http://hdl.handle.net/10962/67603.
Повний текст джерелаDyne, Eric D. "Magnetic Nanoparticle Hyperthermia-Mediated Clearance of Beta-amyloid Plaques: Implications in the Treatment of Alzheimer’s Disease." Kent State University / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=kent1618706341759415.
Повний текст джерелаGuo, Pengbo. "Bone targeting nanoparticle as a new platform of antibiotic agent delivery for the treatment of osteomyelitis." Diss., Temple University Libraries, 2019. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/577034.
Повний текст джерелаPh.D.
Osteomyelitis is a bone infection disease that is caused by microbes. One of the reason that a successful antimicrobial therapy has not been achieved in bone related infection is due to the physiological and structural limitations and multi-drug resistant bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA). Alendronate, a type of bisphosphonate, is a commonly used drug to treat osteoporosis that can strongly chelate with the calcium ions in bone mineral (hydroxyapatite), could be utilized as an active targeting moiety in a drug delivery system to bone tissues. Since nanomedicine can provide a robust drug delivery platform, with the properties of encapsulating molecules of different hydrophilicity, tunable drug release profile, and potential of differential targeting cells and tissues, we proposed a lipid-polymer nanoparticle system, Bone-Targeting Nanoparticle (BTN), with surface modified with covalently bonded alendronate. In this study, BTN encapsulates linezolid, which has dose-related adverse effect that prevent long duration usage. According to our current results, BTN demonstrates three distinguished traits that potentially improves the therapeutic effect of linezolid towards MRSA induced osteomyelitis: a) a hydrophobic polymeric core that can encapsulate a high amount of linezolid; b) alendronate as a targeting moiety that can guide BTN to bone tissue and accumulate near the site of infection; and c) a PEGylated lipid interface that can enhance the drug release profile and provide increased serum stability relative to standard delivery methods.
Temple University--Theses
Kennell, Carly M. "Synthesis and Characterization of Hybrid Co-Delivery Nanoparticles for Triple Negative Breast Cancer Treatment." University of Cincinnati / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1470741290.
Повний текст джерелаStolzoff, Michelle L. "Designing the surface properties of expansile nanoparticles for targeted cancer therapy." Thesis, Boston University, 2013. https://hdl.handle.net/2144/21256.
Повний текст джерелаNanoparticle-based drug delivery has been explored to circumvent the often-toxic chemotherapy treatments used today by providing a more efficient and specific delivery to diseased tissues. Recently we have developed polymeric pH-responsive expansile nanoparticles (eNPs) for intracellular delivery of paclitaxel (Pax) as an improvement upon the traditional methods of delivery of Pax with using Cremophor/ethanol. As eNPs are internalized by the cell, the hydrophobic protecting groups found on side chains along the polymer backbone are hydrolyzed, leaving behind hydrophilic moieties that cause the eNPs to slowly swell with water. In this manner, the encapsulation and controlled release of a hydrophobic drug can be achieved. By altering the surface characteristics of the eNPs, one can change the behavior of the delivery vehicle as well as the biological response. To explore this approach, two surfactant strategies were employed. Specifically, the original sodium dodecyl sulfate (SDS) surfactant has been substituted with PEGylated surfactants (either lipids or poloxamer) to improve circulation and in vivo stability. In addition, these surfactants were functionalized to target the folate receptor (FR), which is overexpressed in several cancers, in order to increase cancer cell-specific localization and uptake. The resulting eNPs retained their swelling characteristics while demonstrating improved cellular uptake in folate receptor-expressing KB and MDA-MB-231 carcinoma cells with no change in uptake in A549 cells, which do not express the folate receptor.
2031-01-01
Zamora, Pérez Paula 1988. "Gold nanoparticle-modified polyelectrolyte nanocapsules as luminescent and photothermal agents for the local treatment of cutaneous melanoma." Doctoral thesis, TDX (Tesis Doctorals en Xarxa), 2021. http://hdl.handle.net/10803/671605.
Повний текст джерелаLas nanocápsulas de polielectrolitos modificadas con nanopartículas de oro presentan propiedades únicas, que les permiten generar luminiscencia y calor mediante exposición a luz. Además, el oro es un material extensivamente estudiado en biomedicina por su estabilidad y seguridad. Esta Tesis propone la aplicación de nanocápsulas de polielectrolito modificadas con nanopartículas de oro, como agentes multifuncionales para el tratamiento localizado del melanoma cutáneo. Esta plataforma, además, permiten la incorporación de agentes terapéuticos/diagnósticos para el desarrollo de nanoterapias avanzadas. Esta Tesis ha investigado la interacción célula-nanocápsula en términos de concentración, internalización, estrés oxidativo e hipoxia, demostrando su perfil biocompatible. Las células de melanoma internalizan las nanocápsulas tras 24 h de exposición, pudiendo localizarlas en lisosomas (ácidos) preservando su estructura y resistiendo la degradación. El calor producido tras el tratamiento fototérmico de modelos celulares (λ=830 nm) resultó en la desintegración tanto de las nanocápsulas como de la estructura celular (necrosis). Mediante el control de la temperatura, se observó inducción de estrés oxidativo y muerte celular programada (apoptosis). Gracias a sus propiedades luminiscentes (λ=830 nm), se pudo relacionar cantidad de nanocápsulas con la eficiencia antitumoral de la terapia fototérmica in vitro. El tratamiento fototérmico de melanomas in vivo (λ=806 nm), resultó en una reducción tumoral completa. Además, la administración intratumoral de las nanocápsulas evitó su distribución sistémica, siendo eliminadas principalmente con el tejido necrótico formado tras el tratamiento. La distribución de las nanocápsulas tras 24 horas post-administración, fue óptima para el éxito del tratamiento fototérmico en melanomas de 5 días de crecimiento. Todo ello hace de las nanocápsulas, un agente fototérmico prometedor para el tratamiento selectivo de tumores sólidos superficiales como el melanoma.
Huang, Wei. "Assembly, characterization and evaluation of a 3rd generation nanoparticle based drug carrier for metastatic breast cancer treatment." Diss., Virginia Tech, 2013. http://hdl.handle.net/10919/50932.
Повний текст джерелаPh. D.
Eschweiler, Zachary Taylor. "Superparamagnetic Nanoparticle TechnologyAn Analysis of Water, Water-treatment, Health-risks of Contaminated Water, and a Proposed Solution." Case Western Reserve University School of Graduate Studies / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=case1497012927923017.
Повний текст джерелаBölükbaş, Deniz Ali [Verfasser], and Silke [Akademischer Betreuer] Meiners. "Development of novel nanoparticle-based therapeutics for treatment of lung cancer / Deniz Ali Bölükbaş ; Betreuer: Silke Meiners." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2017. http://d-nb.info/1137466707/34.
Повний текст джерелаMoon, Taylor J. "Development of a Dual-Agonist Immunostimulatory Nanoparticle to Trigger Interferon β-Driven Anti-Tumor Immunity". Case Western Reserve University School of Graduate Studies / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=case1607349015331713.
Повний текст джерелаGilliland, Stanley E. III. "Modified Seed Growth of Iron Oxide Nanoparticles in Benzyl Alcohol: Magnetic Nanoparticles for Radio Frequency Hyperthermia Treatment of Cancer." VCU Scholars Compass, 2014. http://scholarscompass.vcu.edu/etd/3611.
Повний текст джерелаGuha, Ingrid F. "Effects of silica nanoparticle surface treatment and average diameter on the physical and mechanical properties of poly(dimethylsiloxane)-silica nanocomposites." Thesis, Massachusetts Institute of Technology, 2010. http://hdl.handle.net/1721.1/118564.
Повний текст джерелаCataloged from PDF version of thesis.
Includes bibliographical references (pages 35-37).
The purpose of this thesis was to quantify the effects of silica nanoparticle surface treatments and average silica nanoparticle diameter on various macroscopic properties of poly(dimethylsiloxane)-silica nanocomposites, specifically stiffness, wettability, and permeability to organic solvents. Poly(dimethylsiloxane)-silica nancomposites were prepared with constant amounts (4.8 wt%, 1.8 vol%) of fumed silica nanoparticles with varying surface treatments (hexamethyldisilazane and octamethylcyclotetrasiloxane) and varying particle diameter (7 and 12 nm). The Young's elastic modulus, mass increase due to dodecane absorption after 10 minutes, and advancing and receding water contact angles were measured for each nanocomposite. PDMS-silica nanocomposites containing untreated silica nanoparticles were found to have a higher Young's elastic modulus than nanocomposites containing hexamethyldisilazane-treated silica nanoparticles with the same diameter. However, nanocomposites containing identically sized silica nanoparticles with and without the octamethylcyclotetrasiloxane surface treatment had the same stiffness. The average nanocomposite stiffness increased slightly as the untreated silica nanoparticle diameter decreased from 12 nm to 7 nm. Varying the surface treatment or particle diameter of the filler did not significantly affect the level of dodecane absorption or the wettability of the nanocomposite. All nanocomposites showed approximately 20-23 wt% increase from dodecane absorption after 10 minutes of dodecane immersion. All nanocomposites exhibited average advancing contact angles around 115-120° and average receding contact angles around 85-90°. Nanocomposites were imaged using optical coherence tomography to examine particle dispersion. Potential differences in particle dispersion are discussed.
by Ingrid F. Guha.
S.B.
Jones, Bernard Lee. "Development of dosimetry and imaging techniques for pre-clinical studies of gold nanoparticle-aided radiation therapy." Diss., Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/43727.
Повний текст джерелаVerry, Camille. "Traitement des métastases cérébrales par radiothérapie et nanoparticule de gadolinium : du modèle pré clinique à l'utilisation chez l'homme Treatment of multiple brain metastases using gadolinium nanoparticles and radiotherapy: NANO-RAD, a phase 1 study protocol First in man injection of gadolinium-chelated based nanoparticle (AGuIX®) as theranostic agent for treatment of multiple brain metastases by adiotherapy: a case report." Thesis, Université Grenoble Alpes (ComUE), 2018. http://www.theses.fr/2018GREAS029.
Повний текст джерелаThe occurrence of multiple brain metastases is a critical evolution of many cancers with a major impact on overall survival. A new gadolinium-based nanoparticle, AGuIX®, has recently demonstrated its efficacy as a radiosensitizer and MRI contrast agent in several preclinical studies. The objective of this thesis is to establish a proof of concept on an animal model and then to perform the first administration of this new drug in humans in a phase 1 trial. The first part of this work consisted of a 6 MeV irradiation after AGuIX® injection of a Fisher rat model carrying 9L cerebral gliomas assessed by MRI. A favorable distribution of nanoparticles was observed by EPR effect (Enhanced Permeability and Retention) with a concentration of gadolinium into the tumor 20 times higher than in healthy brain. The radiosensitizing effect was demonstrated with a significant decrease in tumor size (p=0.02) for the irradiated group with AGuIX® injection. These results, combined with the favorable safety profile in animal models, motivated the transfer of this new drug to humans in a Phase 1 study named NANO-RAD (EudraCT2015-004259-30; NCT02820454). This is a monocentric, open-label study evaluating the feasibility and safety of AGuIX® combined with whole brain radiation therapy (30 Gy, 10 Fr of 3 Gy) for patients with multiple brain metastases. The main objective is to determine the maximum tolerated dose of nanoparticles with a dose escalation scheme by steps of 3 patients at 15, 30, 50, 75 and 100 mg/kg. Secondary objectives are the pharmacokinetics, distribution of AGuIX® by MRI, intracranial progression-free survival and overall survival. The first human administration was performed at Grenoble University Hospital on 18 July 2016 and the last patient (n=15) was included on 06 February 2018. All metastases, whatever the histological type (lung, melanoma, breast) had a uptake of AGuIX® whose concentration in the tumor was proportional to the injected dose. The average blood half-life is 1h09 (± 26 min). Tolerance to the treatment was good with a dose escalation up to 100 mg/kg, which became the dose selected for further clinical trials. Of the 14 evaluable patients, 12 had a clinical benefit of treatment with a decrease in tumor volume. These preliminary results are promising in terms of safety, distribution and efficacy and should be confirmed by the randomized multicenter Phase 2 study planned for the end of 2018
Le, Hoai Nga [Verfasser], Gianaurelio [Gutachter] Cuniberti, Michael [Gutachter] Stintz, and Sven [Gutachter] Wießner. "A concept for nanoparticle-based photocatalytic treatment of wastewater from textile industry / Hoai Nga Le ; Gutachter: Gianaurelio Cuniberti, Michael Stintz, Sven Wießner." Dresden : Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2018. http://d-nb.info/1226430562/34.
Повний текст джерелаHood, Robert L. "Development of a Fiberoptic Microneedle Device for Simultaneous Co-Delivery of Fluid Agents and Laser Light with Specific Applications in the Treatment of Brain and Bladder Cancers." Diss., Virginia Tech, 2013. http://hdl.handle.net/10919/51678.
Повний текст джерелаPh. D.
Morgan, Dana Lee. "Alkaline hydrothermal treatment of titanate nanostructures." Thesis, Queensland University of Technology, 2010. https://eprints.qut.edu.au/39298/1/Dana_Morgan_Thesis.pdf.
Повний текст джерелаHasan, Mohammad Nazmul. "Developing Glycopeptide based nanocarriers by ring opening polymerization for drug delivery applications." Thesis, Uppsala universitet, Institutionen för kemi - Ångström, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-233891.
Повний текст джерелаWilcox, Ashley M. "Silver Nanoparticles: An effective antibacterial agent against Gram-negative bacteria." Wright State University / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=wright1576621225597745.
Повний текст джерелаOuvinha, De Oliveira Rachel. "Development and evaluation of nanoparticles for cancer treatment." Thesis, Paris 11, 2014. http://www.theses.fr/2014PA114808/document.
Повний текст джерелаThis thesis concerns the development and evaluation of nanoparticles for cancer treatment, and in particular to prostate cancer. The manuscript includes a literature review on the application of nanomedicine to the treatment of prostate cancer. In the first experimental part, functionalized gold nanoparticles were characterized and loaded with docetaxel by non covalent adsorption. These gold nanoparticles showed a sustained cytotoxic effect in vitro against prostate cancer cells. The second experimental part of this thesis describes a study of synthesis and nanoprecipitation of polyesters for the co-delivery of two chemotherapeutic drugs, docetaxel (DOC) and mitoxantrone (MIT). Polycaprolactone, poly(lactic acid) and poly (lactide-co-glycolide) were synthesized by ring-opening polymerization with different molecular weights of polyethylene glycol. Monodisperse nanoparticles with diameters of less than 80 nm were produced and were shown to be effective against prostate cancer cells when loaded with MIT and DOC. Moreover, a synergistic effect was observed using combinations of these nanoparticles. Therefore, these polyester based nanoparticles have potential clinical applications
Franke, Christina E. "Tobacco Mosaic Virus Nanocarrier for Restored Cisplatin Efficacy in Platinum-Resistant Ovarian Cancer." Case Western Reserve University School of Graduate Studies / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=case1493810190306879.
Повний текст джерелаBarton, Lauren Elizabeth. "Fate and Transformation of Metal-(Oxide) Nanoparticles in Wastewater Treatment." Diss., Aix-Marseille, 2014. http://hdl.handle.net/10161/8661.
Повний текст джерелаThe study and application of materials possessing size dimensions in the nano scale range and, as a result, unique properties have led to the birth of a new field; nanotechnology. Scientists and engineers have discovered and are exploiting the novel physicochemical characteristics of nanoparticles (NPs) to enhance consumer products and technologies in ways superior to their bulk counterparts. Escalating production and use of NPs will unavoidably lead to release and exposure to environmental systems. This introduction of emerging potential contaminant NPs will provide new and interesting challenges for exposure and risk forecasting as well as environmental endurance.
The ultimate goal of this research is to develop a framework that incorporates experimental and computational efforts to assess and better understand the exposure of metal and metal-oxide NPs released to wastewater treatment plants (WWTPs) and further implications on land application units (LAUs) where biosolids can be applied. The foundation of the computational effort is comprised of Monte Carlo mass balance models that account for the unique processes affecting NP fate and transport through the different technical compartments of a WWTP and LAU. Functional assay and bioreactor experiments in environmental media were used to determine parameters capable of describing the critical processes that impact the fate of NPs in wastewater.
The results of this research indicate that a simplified, but still environmentally relevant nano-specific exposure assessment is possible through experimentation to parameterize adapted models. Black box modeling efforts, which have been shown in previous studies, show no disadvantage relative to discretization of technical compartments as long as all key transport and fate mechanisms are considered. The distribution coefficient (_), an experimentally determined, time-dependent parameter, can be used to predict the distribution of NPs between the liquid and solid phase in WWTPs. In addition, this parameter can be utilized a step further for the estimation of the more fundamental, time independent attachment efficiency between the NPs and the solids in wastewater. The NP core, size, and surface coating will influence the value of these parameters in addition to the background particle characteristics as the parameters are specific to the environmental system of study. For the metal and metal-oxide NPs studied, preferential overall association of approximately 90% or greater with the solid phase of wastewater was observed and predicted.
Furthermore, NP transformations including dissolution, redox reactions, and adsorption can potentially impact exposure. For example, experimental results showed that nano-CeO2 is reduced from Ce(IV) to Ce(III) when in contact with wastewater bacteria where Ce2S3 will likely govern the Ce(III) phase in biosolids. From the literature, similar transformations have been observed with Ag and ZnO NPs to Ag2S and ZnS. With respect to TiO2 NPs, studies indicated that due to high insolubility, these NPs would not undergo transformation in WWTPs. The distribution and transformation rate coefficients can then be used in fate models to predict the NP species exposed to aquatic and terrestrial systems and environmentally relevant concentrations released from WWTPs.
Upon completion of the WWTP model, the predicted concentrations of NPs and NP transformation byproducts released in effluent and biosolids were attainable. A simple mass balance model for NP fate in LAUs was then developed to use this output. Results indicate that NP loading on LAUs would be very low but that build up over time to steady state could result in mass concentrations on the order of the typical level for the background metal in soil. Transport processes of plant uptake and leaching were expected to greatly impact the solid phase concentration of the NPs remaining in the LAU, while rainfall did not impart a significant influence upon variation between low and high annual amounts. The significance of this research is the introduction of a method for NP exposure assessment in WWTPs and subsequently in LAUs. This work describes and quantifies the key processes that will impact Ag, TiO2, CeO2 and ZnO NP fate and transport, which can inform future studies, the modeling community and regulatory agencies.
Dissertation
Fallon, Marissa S. "Drug overdose treatment by nanoparticles." [Gainesville, Fla.] : University of Florida, 2005. http://purl.fcla.edu/fcla/etd/UFE0013055.
Повний текст джерелаEbeid, Kareem Atef Nassar. "Nanoparticles for targeted treatment of cancer." Diss., University of Iowa, 2018. https://ir.uiowa.edu/etd/6567.
Повний текст джерелаJain, Rohan. "Biogenic nanoparticles of elemental selenium : synthesis, characterization and relevance in wastewater treatment." Thesis, Paris Est, 2014. http://www.theses.fr/2014PEST1178/document.
Повний текст джерелаNanoparticles exhibit many unique properties as compared to the bulk materials owning to their high surface to volume ratio. Elemental selenium nanoparticles also exhibit novel properties that are exploited in formation of solar cells, semiconductor rectifiers and removal of mercury and copper. However, the chemical synthesis of elemental selenium nanoparticles is costly, requires specialized equipments and uses toxic chemicals. On the other hand, biological production of elemental selenium nanoparticles (BioSeNPs) can be a green replacement for the chemically produced ones.BioSeNPs are produced by microbial reduction of selenite and selenate. The source of the selenium oxyanions can be the wastewaters, where microbial reduction is employed as a remediation technology for the removal of selenium. The formed BioSeNPs are colloidal poly-disperse particles with negative surface charge and are present in the effluent of the microbial reactor. However, the properties of these BioSeNPs are not very well understood. This knowledge would help us to produce better quality selenium nanomaterials, exploit produced BioSeNPs in the wastewater treatment and control the fate of these BioSeNPs in the microbial reactors. The characterization of BioSeNPs revealed the presence of the extracellular polymeric substances (EPS) on the surface of BioSeNPs. The EPS was identified to control the surface charge and to some extent the shape of the BioSeNPs. It was also found that the microbial reduction at 55 and 65 °C can lead to the formation of selenium nanowires as compared to nanospheres when the reduction takes place at 30 °C. These selenium nanowires are present in trigonal crystalline structure and are colloidal suspension, unlike the chemically formed trigonal selenium nanorods. This colloidal nature is due to negative ζ-potential values owning to the presence of EPS on the surface of biogenic selenium nanowires. Since proteins are a major component present in the EPS, the presence of various proteins on the surface of BioSeNPs was determined. The interaction of the various amino acids with the BioSeNPs was also evaluated.The interaction of heavy metals and BioSeNPs was studied with a view of developing a technology where BioSeNPs present in the effluent of an upflow anaerobic sludge blanket (UASB) reactor are mixed with heavy metals containing wastewater leading to removal of both BioSeNPs and heavy metals. It was found that Cu, Cd and Zn can be effectively adsorbed onto BioSeNPs. Cu was 4.7 times preferentially adsorbed onto BioSeNPs. The interaction of BioSeNPs with the heavy metals led to less negative ζ-potential of BioSeNPs loaded with heavy metals and thus better settling of BioSeNPs was achieved. The presence of BioSeNPs in the effluent of the microbial reactor treating selenium oxyanions containing wastewaters is undesirable due to higher total selenium concentrations. Thus, the attempts to capture of these BioSeNPs in the biomass/bioreactors were made. The activated sludge reactor system was investigated to aerobically reduce selenite to BioSeNPs and trap them in the activated sludge flocs. Around 80% of the fed selenium was trapped in the biomass. Sequential extraction revealed that the trapped selenium is BioSeNPs. The trapping of BioSeNPs in the sludge improved the settleability and hydrophilicity of the activated sludge flocs. When the UASB reactor were operated under mesophilic and thermophilic conditions, the total selenium concentration in the effluent under thermophilic conditions were lower than that of observed in mesophilic conditions suggesting better trapping of BioSeNPs.Keywords: Selenium, bioreduction, BioSeNPs, EPS, ζ-potential, heavy metals, activated sludge, UASB reactors, thermophilic