Дисертації з теми "Nanoparticle gold"
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Derrien, Thomas. "Gold nanoparticle-lipid bilayer interactions." Thesis, McGill University, 2010. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=86727.
Повний текст джерелаL'interaction des nanoparticules d'or avec les bicouches lipidiques est présentée dans ce mémoire. Les facteurs influençant cette interaction ont été explorés en utilisant des bicouches lipidiques synthétiques. L'interaction due à l'incorporation des nanoparticules au sein des bicouches a été étudiée par des techniques d'imagerie. Un test de fuite de fluorophore a été employé afin de déterminer l'influence de la composition et de la structure des ligands protégeant les nanoparticules sur leur incorporation dans les bicouches de lipides. Pour cela, nous avons développer une synthèse de nanoparticules protégées par deux types de ligands. Des expériences in vivo ont été réalises avec des nanoparticules d'or fonctionnalisées avec des peptides ainsi que des fluorophores, mis en contact avec des cellules vivantes de type HeLa. Nous avons constaté que les nanoparticules d'or sont capables de franchir les bicouches lipidiques en utilisant des mécanismes indépendants d'énergie. Nous concluons que la structure et la composition des ligands protégeant les nanoparticules ont une grande influence sur la perturbation qu'elles induisent dans la structure des bicouches lipidiques.
Manohar, Nivedh Harshan. "Quantitative imaging of gold nanoparticle distribution for preclinical studies of gold nanoparticle-aided radiation therapy." Diss., Georgia Institute of Technology, 2015. http://hdl.handle.net/1853/54877.
Повний текст джерелаJones, Bernard. "Monte Carlo calculations of microscopic dose enhancement for gold nanoparticle-aided radiation therapy." Thesis, Georgia Institute of Technology, 2009. http://hdl.handle.net/1853/34746.
Повний текст джерелаCrew, Elizabeth. "Nanoparticle-based analytical/bioanalytical probes investigation of interactions and reactivities between gold nanoparticles and homocysteine /." Diss., Online access via UMI:, 2005. http://wwwlib.umi.com/dissertations/fullcit/1425749.
Повний текст джерелаKanaras, Antonios G. "Enzymatic manipulation of DNA/gold nanoparticle assemblies." Thesis, University of Liverpool, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.402259.
Повний текст джерелаBennett, Samantha E. "Fabrication of water-soluble gold nanoparticle aggregates." Thesis, Massachusetts Institute of Technology, 2006. http://hdl.handle.net/1721.1/35074.
Повний текст джерелаIncludes bibliographical references (leaves 23-24).
Mixed monolayer protected gold nanoparticles were linked using octanedithiol to form aggregates containing hundreds of nanoparticles. These aggregates are an interesting material, posing potential applications in the fields of chemistry, biology and materials science. This study examined the dependence of aggregate size and morphology on temperature of formation, using AFM and TEM imaging. The aggregates formed at 70°C averaged 105nm in width, as compared to 70nm for the room temperature aggregates. The TEM images showed increased density for the 70°C aggregates. In a further study, the room temperature aggregates were functionalized through a place exchange reaction with 1 -mercapto-undecane- l-sodiumsulfonate (MUS), a thiolated ligand with a polar head group. A two-phase test of the water-solubility indicated that the aggregates were fully soluble. TEM images showed a slight increase in size, though similar morphology to the insoluble aggregates. The ability to induce water solubility in the aggregates opens up many potential applications in the field of bionanomaterials.
by Samantha E. Bennett.
S.B.
Zarate-Triviño, D. G., Acosta E. M. Valenzuela, E. Prokhorov, G. Luna-Bárcenas, Padilla C. Rodríguez, and Molina M. A. Franco. "Chitosan-Gold Nanoparticle Composites for Biomedical Application." Thesis, Sumy State University, 2013. http://essuir.sumdu.edu.ua/handle/123456789/35404.
Повний текст джерелаGarcía, Fernández Lorena. "Introducing gold nanoparticle bioconjugates within the biological machinery." Doctoral thesis, Universitat Autònoma de Barcelona, 2013. http://hdl.handle.net/10803/120221.
Повний текст джерелаThe rapid development in Nanotechnology during the past few decades offers wide prospects in using micro- and nanoscale materials in different areas of industry, technology and medicine. However, their safe and efficient use and implementation in such areas require much greater control over their physicochemical properties and their related molecular interactions in living systems. Current knowledge in the scientific community agrees that a considerable gap exists in our understanding of such “Nano-Bio” interface. As a step forward in this direction, this Thesis work aimed to provide insights into the formation of rationally designed gold nanoparticle (Au NP) bioconjugate architectures to modulate and understand cellular interactions and processes. In such a context, the first part of this Thesis is focused on the synthesis of cationic Au NPs and their interactions with cells. A first strategy was developed in which the synthesis of positively charged Au NPs was performed by using simultaneously a weak and a strong reducer. It is shown that both reducers act sequentially in a one-pot synthesis to yield monodisperse cationic Au NPs with sizes comprised between 10.3 nm and 19.7 nm. A two-step seeding growth method is also described in which preformed Au NPs are grown larger (up to ~28 nm in size) by addition of fresh precursor solution and a weak reducer. A second strategy faces the rising demand of cationic Au NPs of different sizes and ligands by employing an organic-aqueous phase transfer methodology. Important benefits resulted from the combination of organic and aqueous synthetic methods. This strategy was optimized to prepare cationic Au NPs of 4.6, 8.9 and 13.4 nm in diameter using a positively charged alkanethiolate ligand. In addition, its practical application was demonstrated by producing ~ 13-nm-in-size cationic and anionic peptide-Au NP bioconjugates. The physicochemical properties of these bioconjugates in cell culture media as well as their uptake and toxicity on human fibroblast cells are discussed. The second part of this Thesis is focused on the rational functionalization of Au NPs with antibodies and investigating their interactions with cellular receptors. A site-directed chemistry was explored to prepare Antibody-Au NP bioconjugates with controlled ratio and orientation of bioconjugation. The formation of well-defined bioconjugates made possible the creation of novel NP-based assemblies using antibody-antigen cross-links. This strategy was also explored for the conjugation of a biologically relevant antibody (Cetuximab) with Au NPs. Cetuximab-Au NP bioconjugates of controlled configuration and multivalency were used to examine their interaction with the cell surface receptor EGFR (epidermal growth factor receptor), a receptor tyrosine kinase overexpressed in a large number of cancers.
Tombe, Sekai Lana. "Characterization and application of phthalocyanine-gold nanoparticle conjugates." Thesis, Rhodes University, 2013. http://hdl.handle.net/10962/d1004517.
Повний текст джерелаMicrosoft� Word 2010
Adobe Acrobat 9.53 Paper Capture Plug-in
Mthethwa, Thandekile Phakamisiwe. "Metallophthalocyanine-gold nanoparticle conjugates for photodynamic antimicrobial chemotherapy." Thesis, Rhodes University, 2015. http://hdl.handle.net/10962/d1017923.
Повний текст джерелаNgomane, Nokuthula. "Gold nanoparticle–based colorimetric probes for dopamine detection." Thesis, Rhodes University, 2016. http://hdl.handle.net/10962/d1021261.
Повний текст джерелаZhao, Pengxiang. "Nanoparticules d’ or : fonctionnalisations et applications en nanomédecine et nanomatériaux." Thesis, Bordeaux 1, 2012. http://www.theses.fr/2012BOR14556/document.
Повний текст джерелаThe thesis concerns functionalizations and applications of gold nanoparticles (AuNPs). In the aspects of functionalization of AuNPs, we concentrated on efficiently functionalized AuNPs by “Click” chemistry. In the aspects of applications, the PEG capped AuNPs was prepared to encapsulate vitamins, which has a potential use in hydrophobic part of human body; the folate functionalized AuNPs was used for docetaxel delivery for cancer therapy; the novel synthesis of triazole stabilized AuNPs used for biosensors; and the citrate capped AuNPs introduced into the silica thin films to check the SERS effect and spin crossover of iron complexes
McLeod, Angus R. "Characterisation of gold nanoparticles on substrate." Thesis, Queensland University of Technology, 2015. https://eprints.qut.edu.au/80106/5/Angus_McLeod_Thesis.pdf.
Повний текст джерелаRoberts, Robert Christopher. "Jet Printed Au Nanoparticle Films For Microelectromechanical Systems." Case Western Reserve University School of Graduate Studies / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=case1342809712.
Повний текст джерелаWardlow, Nathan. "Role of local enhancement effects in gold nanoparticle therapy." Thesis, Queen's University Belfast, 2017. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.728684.
Повний текст джерелаMuir, M. F. "Gold nanoparticle dose enhancement and plasma induced cellular damage." Thesis, Queen's University Belfast, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.580102.
Повний текст джерелаTaylor, Richard William. "On the sub-nm plasmonics of gold nanoparticle clusters." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648264.
Повний текст джерелаRao, Tingling. "Nanomanufacturing of Gold Nanoparticle Superstructures from the "Bottom-Up"." University of Akron / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=akron1366289133.
Повний текст джерелаSmith, Beverly. "Investigating Thermal Transformations of Ligand-Stabilized Gold Nanoparticles: Influence of the Structural Attributes of the Nanoparticle and Its Environment on Thermal Stability." Thesis, University of Oregon, 2015. http://hdl.handle.net/1794/19259.
Повний текст джерела10000-01-01
Tang, Lu. "Nanoparticules mimes des propriétés biologiques des GAGs : vers un inhibiteur sélectif de CXCL12." Thesis, Université Paris-Saclay (ComUE), 2015. http://www.theses.fr/2015SACLS072.
Повний текст джерелаHéparan Sulfate (HS) is a linear polysaccharide that modulates the biological activities of numerous proteins. In order to elucidate the interaction between HS and proteins, the synthesis of HS is an invaluable tool, but the synthesis is sometimes difficult. Our group has demonstrated that the combinatorial mixtures obtained by self-assembly of different combinations of disaccharide derivatives (lactose and persulfated lactose) on gold plan surfaces could recognize specifically some HS binding proteins, such as the isoforms of the chemokine CXCL12 or IFNγ. Because of the toxicity of gold nanoparticles, we have also adapted this method to lipid nanoparticles. Using the conditions that have already improved during the synthesis of lactose and persulfated lactose derivatives, we have synthesized two other disaccharide derivatives, which were closer to the real structure of HS. These new derivatives were used to prepare the gold and lipid nanoparticles at the aim of comparing the properties with lactose and persulfated lactose. The tests of affinities with different proteins are in progress
Geitner, Nicholas. "A Study of Gold Nanoparticles for Application in Semiconductor CdS Nanosheet Biosensor Devices." Miami University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=miami1311893825.
Повний текст джерелаMukundarajan, Sriram. "Synthesis of Alkylthiol-containing Fluorene Derivatives for Gold Nanoparticle Functionalization." Master's thesis, University of Central Florida, 2005. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/3570.
Повний текст джерелаM.S.
Department of Chemistry
Arts and Sciences
Industrial Chemistry
Almeida, Carina Marisa dos Santos. "Gold nanoparticle-DNA conjugates for oligonucleotide vectorization towards gene silencing." Master's thesis, Faculdade de Ciências e Tecnologia, 2011. http://hdl.handle.net/10362/6212.
Повний текст джерелаThe main objective of the work presented in this thesis was to develop a gene silencing system by taking advantage of the nanovectorization capability and optical properties of gold nanoparticles. The idea is based on the construction of a DNA structure containing a therapeutic oligonucleotide with the ability to form Hoogsteen hydrogen bonds with double-stranded DNA, producing a DNA triple helix, besides silencing the gene of interest. Hoogsteen bonds, more unstable than the conventional Watson-Crick bonds, permit the achievement of lower melting temperatures. This attribute, coupled with the ability to generate heat by laser irradiation of the gold nanoparticles used, will allow the release of the therapeutic oligonucleotide and subsequent gene silencing without significant increase in the medium’s temperature. Thus, the thesis comprises three major sections: structure design and formation, vectorization, and gene expression silencing; the tasks involved in each of these sections were conducted in parallel. The design of the obtained structure took into account the desired melting temperature, stability at physiological conditions of the sequence-forming nucleotides, the number of Hoogsteen bonds and ionic conditions. To evaluate the formation of this structure, spectroscopic techniques were mainly used: FRET analysis and ultraviolet melting curves. Both approaches allowed the identification of interactions in the presence of therapeutic oligonucleotide compared with its absence, which may indicate structure formation. In addition, melting curves allowed the determination of the temperature of release of this oligonucleotide – 40ºC. The double-stranded DNA functionalization to gold nanoparticles has been achieved, but there was no difference in electrophoretic migration when the three oligonucleotides were present. However, the therapeutic oligonucleotide was able to efficiently inhibit gene expression in in vitro transcription and translation assays with efficiency up to 95% and 60% respectively.
Acreman, Andrew. "Gold nanoparticle liquid crystal composites : synthesis, characterisation and optical nonlinearities." Thesis, University of Southampton, 2015. https://eprints.soton.ac.uk/379319/.
Повний текст джерелаDaugherty, Brian Taylor. "Improved Detection of Gold Nanoparticle Labels for Paper-based Analytics." DigitalCommons@CalPoly, 2015. https://digitalcommons.calpoly.edu/theses/1437.
Повний текст джерелаDonoeva, Baira. "Study of catalytic and biological activity of gold-containing metal nanoparticles." Thesis, University of Canterbury. Chemistry, 2014. http://hdl.handle.net/10092/9761.
Повний текст джерелаAustin, Lauren Anne. "Exploring some aspects of cancer cell biology with plasmonic nanoparticles." Diss., Georgia Institute of Technology, 2014. http://hdl.handle.net/1853/54236.
Повний текст джерелаEroglu, Esra. "Synthesis And Characterization Of New Conducting Polymer- Nano Particle Composites." Master's thesis, METU, 2013. http://etd.lib.metu.edu.tr/upload/12615631/index.pdf.
Повний текст джерела2-(9,9-dihexyl-2-(thiophen-2-yl)-9H-fluoren-7-yl)thiophene (TFT) and 5-(9,9-dihexyl-2-(2,3-dihydrothieno[3,4-b][1,4]dioxin-5-yl)-9H-fluoren-7-yl)-2,3dihydrothieno[3,4b ][1,4] dioxine (EFE) were synthesized on the basis of donor-acceptor-donor approach and their electrochemical polymerization were achieved via potential cycling. Optical and electrochemical properties of their corresponding polymers, poly(2-(9,9-dihexyl-2-(thiophen-2-yl)-9H-fluoren-7-yl)thiophene) PTFT, and poly(5-(9,9-dihexyl-2-(2,3-dihydrothieno[3,4-b][1,4]dioxin-5-yl)-9H-fluoren-7-yl)-2,3dihydrothieno[3,4b ][1,4] dioxine) PEFE, were investigated and it was found that polymer films exhibited quasi-reversible redox behavior (Epox= 1.10 V for PTFT, Epox = 0.70 V and 1.00 V for PEFE) accompanied with a reversible electrochromic behavior, yellow to dark green for PTFT, yellow to parliament blue for PEFE. Their band gap values (Eg) were found to be 2.36 eV and 2.26 eV for PTFT and PEFE, respectively. Furthermore, gold nanoparticles (AuNP) were prepared and their interaction with polymer films, PTFT and PEFE, were investigated using spectroscopic techniques. The fluorescence properties of the polymers and their composites, prepared by the interaction of AuNP with polymers, were also investigated.
Pati, Paramjeet. "Sustainable Nanotechnology: Life Cycle Thinking in Gold Nanoparticle Production and Recycling." Diss., Virginia Tech, 2015. http://hdl.handle.net/10919/75132.
Повний текст джерелаPh. D.
Sugden, Mark William. "Electrical and optical assessment of thiol encapsulated gold nanoparticle thin films." Thesis, University of Sheffield, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.538003.
Повний текст джерелаDavidson, A. M. "High resolution characterisation of gold nanoparticle coronae by differential centrifugal sedimentation." Thesis, University of Liverpool, 2018. http://livrepository.liverpool.ac.uk/3018342/.
Повний текст джерелаChen, Feifei. "Gold nanoparticle mediated membrane permeabilization of phytochemicals into breast cancer cells." Thesis, University of Missouri - Columbia, 2016. http://pqdtopen.proquest.com/#viewpdf?dispub=10180873.
Повний текст джерелаBreast cancer is one of the most common cancers in women with a very high incident rate, especially for those women who are between 40-60 years old. Most drugs are large or non-polar macromolecules, which cannot get into cancer cells autonomously, so a method that can deliver those drugs is very important. Optoporation method has been facilitated with gold nanoparticles, which are bound to breast cancer cells, and then absorb the optical energy to improve the membrane permeabilization. Long-term dietary consumption of fruits and vegetables high in β-carotene and other phytochemicals has been shown beneficial in terms of anti-cancer, anti-aging, preventing cardiovascular disease and cataract. However they are large non-polar molecules that are difficult to enter the cancer cells. Here in this study, we applied optoporation method by using β-carotene, and tetracycline as anti-cancer drugs in various concentrations to optimize highest selective cell death/best potential for T47D breast cancer cell lines.
Shu-HuaChiu and 邱淑華. "Gold nanoparticle-induced catalysis formation of gold/polymer Janus nanoparticles." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/12893514314054474728.
Повний текст джерелаQI, HAO. "Liquid crystal-gold nanoparticle composites." 2009. http://hdl.handle.net/1993/3166.
Повний текст джерелаLee, Po-Han, and 李柏漢. "Multifunctional Nanocomposite of Upconversion Nanoparticle with Different Morphology of Gold Nanoparticles." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/81835215999949797699.
Повний текст джерела國立臺灣大學
化學研究所
102
Upconversion nanoparticles (UCNPs) refer to a highly potent nanomaterial for bioassay and bioimage because it can convert two or more low energy photons to a high energy photon. We demonstrate a nanocomposite consisting of UCNPs and gold nanoparticles as a multifunctional nanomaterial to apply in biomedical application. Noble metallic nanoparticles such as gold nanoparticle have a unique optical property because of the surface plasmon resonance (SPR). Furthermore NaYF4:Yb/Er upconversion nanoparticles emit the photoluminescence from green-to-red which can provide gold nanoparticles inducing photothermal effect. We further used silica coated UCNPs to functionalize amino groups on silica shell to combine 3.5 nm gold nanoparticles (UCNP@SiO2-AuNPs) or gold nanorods (UCNP@SiO2-AuNRs). The size of UCNPs and UCNP@SiO2 are define as 19 ± 1.1 nm and 26 ± 0.5 nm by HRTEM, respectively, and the silica shell is 3 ± 0.5 nm. According to the result of photoluminescence spectra, the intensity of UCNP@SiO2-AuNRs is lower than UCNP@SiO2-AuNPs and this confirm highly energy transfer from UCNP to gold nanorods. In vitro cytotoxicity study, this nanocomposites is nontoxicty to oral cancer cell through the MTT assay even the concentration of nanocomposites approaching 250 μg/mL. The photothermal effect of UCNP@SiO2-AuNRs is demonstrated by irradiating a 980 nm laser and staining with trypan blue, there is huge cell death compare to UCNP@SiO2-AuNPs. In summary, we successfully develop nanocomposites based on UCNPs which reveal obviously photothermal effect and cell imaging to overcome non-fluorescent material like gold nanorods as nanocarriers in biological application.
Jing-XiangHong and 洪靖翔. "Gold nanoparticle-based antibody probes forimmuoprecipitation." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/36615475851946129760.
Повний текст джерелаCheng, De-Ming, and 鄭德銘. "Plasmonic Coupling of Gold Nanoparticle on Gold Film: Experiment and Simulation." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/x5f7w8.
Повний текст джерела國立東華大學
物理學系
107
Previous studies had shown that plasmonic coupling between gold nanoparticle and gold film was highly sensitive with their extremely close gap distance. Different ways were provided to define nanogap between gold nanoparticles and gold film for plasmonic coupling effect. In order to systematically study coupling effect in an extremely close distance, self-assembly monolayer technique were used in this work. We modified four kind of molecular (3-Mercaptopropionic acid (3-MPA), 6-Mercaptohexanoic acid (6-MHA), 11-Mercaptoundecanoic acid (11-MUA), 16-Mercaptohexadecanoic acid (16-MHA)) with different length on the surface of 50 nm gold nanoparticle and Cysteamine on the gold film. By centrifugal process, we can easily deposit gold nanoparticles on gold film and control their gap distance through modified molecular. Experimental results by measuring reflecting spectrum show that there are two characteristic absorption peak when vertical polarization incident. Surface plasma resonance peak shift from 610 nm to 710 nm as gap distance decrease from to . Absorption peak from gold nanoparticle remain at 530 nm. Simulation shows that electric field enhancement between gold nanoparticles and gold film were similarly to experimental resonance wavelength. Two characteristic enhanced wavelength were also found. As gap distance decrease from 5 nm to 0.5 nm, resonance wavelength red shift from 564 nm to 697 nm. For 40 nm particle size, red shift from 575 nm to 665 nm as gap distance decrease from 2 nm to 0.5 nm. Coupling peak related to the size of gold nanoparticles and red-shifted in resonance wavelength following a power law with decreasing film-NPs gap distance. For correspondence, we change our parameter in simulation. 54 nm gold nanoparticles are replaced and apply refractive index n=1.21. As gap distance between gold nanoparticles and gold film set at 3, 2, 1 nm resonance peak shifted to 608, 629, 701 nm, respectively. Simulation results are consistent with experimental measurement though adjust gold nanoparticle diameter and apply refractive index. Furthermore, with the properties of atmospheric hydrogen plasma easily reacting with carbon-bonded molecules we applied short and long time plasma treatment to gold nanoparticles modified with long carbon chain molecular such as 11-MUA and 16-MHA, respectively. With short time process resonance wavelength red shifted slightly, absorption of gold nanoparticles remain in the same. However, in long time plasma treatment (30 min), resonance wavelength evidently shifted from 639 nm to 714 nm for 11-MUA modification, 591 nm to 619 nm for 16-MHA modification. Then, we substitute these results in the experimental fitting curve. It shows that long time plasma treatment for 11-MUA with 0.8 nm shorten gap distance red-shifted occurred in resonance wavelength for 75 nm. And 16-MHA with 1.3 nm shorten distance resonance wavelength red shifted for 28 nm. We also expect that the red shifted of the coupling resonance wavelength caused by the shortening gap distance will slow down as the plasma processing time increases. For modified long carbon chain molecular with long time plasma treatment tend to be stable. Without interaction to plasma gas, distance between gold nanoparticles and gold film no longer decreased leading no change to resonance coupling wavelength in long tome plasma treatment.
Yang, Pei-Qi, and 楊佩琪. "Research on Plasmonic Properties of Gold Nanoparticle." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/00386464387604573081.
Повний текст джерелаChen, Po Yi, and 陳柏宇. "Fluorescent properties of gold nanoparticle supercrystal films." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/27888973076245624715.
Повний текст джерела國立清華大學
物理系
103
In this work, we performed the photoluminescence and plasmon resonance of nanoparticle films. Using the extinction spectra as the basis of signals of plasmon resonance, and we compare the extinction and PL spectra. In the experiment we measure on three kind of nanoparticle films, close-pack gold nanoparticle films change the size and numbers of layer and deposited by using E-beam evaporator. We systematically observed simultaneous red shift in PL and extinction spectra with increasing particle size and confirm that L-mode resonance also contributed to the PL of the multilayer close-pack gold nanoparticle films. For Au nanoparticle film deposited by using E-beam evaporator, we observed blue shift of the photoluminescence peak (relative to the scattering peak).
Rosa, João Miguel Ramalho Fidalgo. "Study of gold nanoparticle assisted neuron stimulation." Master's thesis, 2015. http://hdl.handle.net/10362/16599.
Повний текст джерелаLi, Ping-Yu, and 李秉宇. "Plasmonic Coupling of Gold Nanoparticle on Gold Film with Different Gap Distances." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/8a94p3.
Повний текст джерела國立臺灣海洋大學
光電科學研究所
103
Previous studies reported plasmonic coupling between gold nanoparticle and gold film with gap distance from 0.7nm to 2.1nm. The surfaces of gold nanoparticles with two kinds of particle sizes (12nm and 30nm) were modified with different molecules to create different gap distance. They found that absorption spectrum peak of 30 nm gold nanoparticle coupling with gold film will be red-shifted as the gap distance decreased. Single gold nanoparticle absorption peak was located at 536nm. However, the absorption of 12 nm gold nanoparticle coupling with gold film had two different absorption peaks. Not only coupling peak but also gold nanoparticle absorption peak red-shifted as the gap distance decreased. In this essay, we think the red shift of absorption peak of 12 nm gold nanoparticle on gold film is due to the coupling of gold nanoparticle with the tiny bump on the surface of gold film as the gap becomes small. We used COMSOL3.5a software to simulate the experiment and found absorption peak of 12nm gold nanoparticle on smooth gold film did not red-shift, but fixed at 530nm. By contrast, with the bump on the gold film, the absorption peak of gold nanoparticle red-shifted from 530nm to 561nm. We then observed the absorption spectra of 12nm gold nanoparticle modified with 3-Mercaptopropionic acid (3-MPA) on gold film with four different certified refractive index liquids (1.34, 1.35, 1.36, 1.37). Then, we used Comsol3.5a software to simulate their absorption spectra. All absorption peaks red-shifted as the refractive index increased.
Tou, Pei-Ting, and 竇培庭. "NIH 3T3 cell metabolism with gold nanoparticle infection." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/03404616905609987923.
Повний текст джерела國立中興大學
奈米科學研究所
102
This study started with different concentrations and particle sizes of gold. The gold nanoparticle concentrations were added into NIH 3T3 cells to observe cell growth curve. The cells of a smaller diameter of gold nanoparticles had a more significant impact, so the smaller particles sizes were selected. The gold nanoparticles that were added into NIH 3T3 cells were found to have more swelling and dendritic became shorting observed by Optical microscope. The NIH 3T3 cells in the liquid were used to measure with the AFM (Atomic force microscope), observed the topography of NIH 3T3 cells with the nanoparticles at different times. The second part of this study is by fluorescence microscope, the fluorescence observation have actin skeleton of cells and the endoplasmic reticulum of cells. After adding gold nanoparticle to the actin filaments of NIH 3T3 are broken and appeared as an aspiration of dots and endoplasmic reticulum of cells becomes incomplete. The third part of the mechanical measurements is by AFM. After adding gold nanoparticles, the nucleus and dendritic adhesion force of cell became bigger than the control with increased time. The adhesion force of nucleus is greater than dendritic. The last part, observed the substrate after the conductor layer produced by optical microscope. The SEM (Scanning electrical microscopy) measured the thickness of the parameters of the deposition of silicon nitride insulating layer made and observed the surface. PDMS made for using cultured cells, after on the substrate to test cells can be successfully cultured on the substrate.
Ni, I.-Chih, and 倪懿池. "Gold Nanoparticle Films: Assembly, Patterning,and Physical Properties." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/cz367k.
Повний текст джерела國立東華大學
物理學系
100
Nanostructures consisting of assembled nanoparticles have many interesting electrical and optical properties. For instance, assembled gold nanoparticle (AuNP) films have strong interparticle coupling effect on their surface plasmon resonance, and charge transport in AuNP films exhibits a metal to insulator transition behavior depending on the interparticle spacing s. For their wide applications to novel electric devices, optoelectronic devices, chemical sensing, and surface enhanced Raman scattering, it is important to pursue a simple, efficient method to fabricate two- and three-dimensional conductive, plasmonic AuNP films with well-defined patterns. In this report, we show a novel centrifuge assembly method to fabricate metal (Au, Ag) nanoparticle films with good coverage, morphology, thickness, and surface modification control. Besides, we combined the centrifugal assembly method with top-down lithography method to form two- and three-dimentional (3D) AuNP nanostructures. We also studied the optical and electrical properties of AuNP films. We found that the surface plasma resonance peak wavelength of AuNP films increases as the interparticle spacing s decreases. We also found s and the optical properties of AuNP films are influences by the drying effect, which can be tuned by the interactions of surface modification molecules. The electrical properties also depend on s. The resistances of AuNP films greatly changes with the interparticle spacing s. Further, we found the resistance of AuNP films were enormously reduced after an exposure of electron beam in scanning electron microscopy. The irradiation of electron beam could turn insulator-like AuNP films into metal-like films, and thus can be apply to directly “write” functional nanodevices. The conductance change of AuNP films with different electron dosages and the current-voltage behaviors at different temperatures before and after electron beam irradiation were also studies.
"Characterization of nanocrystals and gold nanoparticle-protein assemblies." Thesis, 2009. http://hdl.handle.net/1911/61892.
Повний текст джерелаChen, Po-Hao, and 陳柏豪. "Rapid detection of Salmonella using gold nanoparticle andimmunochromatography." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/8c459u.
Повний текст джерела國立臺北科技大學
化學工程研究所
99
In recent years, application of DNA molecular detection technology is developing rapidly, such as polymerase chain reaction is the important clinical diagnostic method. PCR method is accurate, but time-consuming, materials-consuming and other issues need to be improved. Therefore, our laboratory developed a immunochromatographic assay which uses DNA molecules, gold nanoparticles(GNPS) and antibodies. We designed biotin-DNA and SH-DNA probes as capture and detection probes, each probe is complementary with Salmonella 16S rDNA. The biotin-DNA probe is associated with avidin and anti-avidin antibody on the nitrocellulose membrane, while the SH-DNA probe is connected to GNPS using covalent bond. With hybridization, immunochromatography methods are used to detect Salmonella. The biggest advantage of this system is that does not require PCR amplification to determine whether a colony of Salmonella. This method can clearly distinguish E.coli between Salmonella. The detection limit of single-stranded DNA is 5 fmol. Furthermore, after silver enhancement, the detection limit is 5 amol. It is rapid, accurate, convenient, low cost and high sensitivity and specificity, which will help clinical use and promotion.
Tsai, Shang-ting, and 蔡尚廷. "Study of dichroic behavior of spherical gold nanoparticle." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/pktzs9.
Повний текст джерела國立臺北科技大學
生化與生醫工程研究所
102
Typically, the color of spherical gold nanoparticles and aggregated nanogold is red and bluish purple, respectively. In this study, dichroic and spherical nanogold was synthesized using a seeding growth method under sodium citrate insufficiency in an aqueous solution. This particular nanogold solution is orange in reflected light and red in transmitted light. With particle assembling, the solution is fainter orange in reflected light, but purple or blue in transmitted light. The current theory for optical properties of gold nanoparticles does not fit the dichroic behaviors of gold nanoparticles. To the best of our knowing, this is the first study to report how the nanogold is synthesized affects the behavior of the nanogold.
Hsieh, Shu-Yi, and 謝書宜. "Gold-Nanoparticle Enhanced Protein Detection in Metallic Nanostructue." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/36160615162873270306.
Повний текст джерелаChan-Yi, Yang, and 楊正義. "The Application of Functionalized Gold Nanoparticle on Biotechnology." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/65701209710329669500.
Повний текст джерела國立臺灣師範大學
化學系
95
Metal and semiconductor nanoparticles coupling with biomolecules have attracted great interests recently because the resulting materials may bring new applications in biological systems. The strong and selective binding of carbohydrate-AuNP to bacterial presents a novel method of labeling specific protein on the cell surface using carbohydrate conjugated nanoparticles. Moreover, in comparison with the conventional sandwich immunoassay, the biomolecule conjugated nanoparticles can provide a relatively easy and direct method to visualize the target receptors on the cell surface under an electron microscope. On the other hands, the multivalent interactions between carbohydrate-AuNPs and target lectins were studied by the SPR technique to quantitatively analyze the binding affinity. The results showed that the binding of mannose encapsulated AuNPs with Con A and galactose encapsulated AuNPs with VAA-I exhibited a strong multivalent effect, and the binding specificity between carbohydrate-AuNP and the lectin was similar to that of the monovalent counterparts. The relative inhibit potency (RIP) values of carbohydrate-AuNPs indicate that the larger size of AuNP and longer ligand length present excellent binding affinity both in interaction with Con A and VAA-I, respectively. Our results demonstrate that gold nanoparticle can serve as an excellent multivalent carbohydrate ligand carrier, providing a new route for designing inhibitors and biological effectors for target proteins.
Yeh, Yi-Cheun, and 葉伊純. "Biomolecule and Gold Interaction: Electrochemistry and Nanoparticle Formation." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/63596894985279133739.
Повний текст джерела國立臺灣師範大學
化學系
95
Cytochrome c is an electron transport protein in biological system. The redox potential of this protein was measured by suing tetraoctylammonium bromide modified gold electrode. In the system, cyt c must diffuse through the TOAB layer to reach the Au surface, and the strong hydrophobic tails of TOAB may trigger cyt c denature. The measured redox potential of -0.1 V is similar to oxygen-bound iron proteins. Spectroelectrochemistry of cyt c was performed in an optically transparent thin-layer electrochemical cell at potential of -0.2 V. The final reduced cyt c exhibits split Q bands at 542, and 575 nm. When cyt c diffused inside TOAB layer, the hydrophobic interaction causes protein structure changes, and affects the iron binding sphere. From the spectrum of the reduced form, we conclude it is a low-spin, five-coordinate ferrous heme. Gold salt, HAuCl4 can be reduced in cyt c solution and gold nanocrystals were formed from this reduction. Transmission electron microscopy (TEM) images showed distorted spherical shapes of gold nanoparticles were formed with excess Cl ions. In the presence of Br- ions, multiple shapes such as triangular, hexagonal nanoplates, decahedral particle and nanorod were formed. Iodide appears to prevent the formation of gold nanocrystals. At pH 3, the Cl- containing cyt c- HAuCl4 solution showed multiple shapes of gold nanocrystals, and TEM images showed gold nanocrystals were formed within the polypeptide. Using cyt c as a reducing agent the sizes and shapes of gold nanocrystals are dominated by the nucleation and growth rate which can be fine-tuned by varying reduction potential, temperature, and pHs.
Hsieh, You-Rong, and 謝侑融. "Thermoelectric Properties of Hematin-Gold Nanoparticle Assembled Films." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/77765191522361556457.
Повний текст джерела國立東華大學
物理學系
103
In recent years, people face the difficulty in lack of energy, so people eager to find other kinds of energies to alternate fossil fuels. Thermoelectric materials could transform thermal energy to electricity directly. However, the efficiency of transformation was not good, so thermoelectric materials didn’t yet be widely used. In researches in small materials, people find that when the size of thermoelectric materials down to nanoscale, their figure of merit will rise obviously in experiment and theory. In this work, we studied the thermoelectric properties of molecule modified gold nanoparticle assembled films influenced by surrounding gases. We use Hematin molecule and deoxygenate the Iron of Hematin (Fe3+→Fe2+)by N2H4 and survey the seebeck coefficient of two materials. We found that the Seebeck coefficient of Hematin(Fe3+)in vacuum(~10-5 Torr),nitrogen(100 Torr) and oxygen(100 Torr) were -19.9 μV/K, -0.02 μV/K and -0.84 μV/K respectively, and the Seebeck coefficient of Hematin(Fe2+) were +40.5 μV/K, -11.8 μV/K and -13.7 μV/K respectively. Because the AuNPs films could adsorb gases, the seebeck coefficient will change by the pressure of gases. In addition, we also estimate the material’s resistivity and power factor. We found that no matter where the Hematin(R)-AuNP molecular lives in vaccum or other surrounding gases, its power factor all lager than Hematin-AuNP. So, from this experiment, we can find that surrounding gases truly have the infiuence on the molecular of thermoelectric.