Готові списки джерел за темами / Nanoparticle biogenesis

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Добірка наукової літератури з теми "Nanoparticle biogenesis"

Автор: Grafiati

Опубліковано: 11 березня 2023

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Статті в журналах з теми "Nanoparticle biogenesis"

Hurwitz, Stephanie N., Meghan M. Conlon, Mark A. Rider, Naomi C. Brownstein, and David G. Meckes. "Nanoparticle analysis sheds budding insights into genetic drivers of extracellular vesicle biogenesis." Journal of Extracellular Vesicles 5, no. 1 (January 2016): 31295. http://dx.doi.org/10.3402/jev.v5.31295.

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Kodiha, Mohamed, Hicham Mahboubi, Dusica Maysinger, and Ursula Stochaj. "Gold Nanoparticles Impinge on Nucleoli and the Stress Response in MCF7 Breast Cancer Cells." Nanobiomedicine 3 (January 1, 2016): 3. http://dx.doi.org/10.5772/62337.

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Cancer cells can take up gold nanoparticles of different morphologies. These particles interact with the plasma membrane and often travel to intracellular organelles. Among organelles, the nucleus is especially susceptible to the damage that is inflicted by gold nanoparticles. Located inside the nucleus, nucleoli are specialized compartments that transcribe ribosomal RNA genes, produce ribosomes and function as cellular stress sensors. Nucleoli are particularly prone to gold nanoparticle-induced injury. As such, small spherical gold nanoparticles and gold nanoflowers interfere with the transcription of ribosomal DNA. However, the underlying mechanisms are not fully understood. In this study, we examined the effects of gold nanoparticles on nucleolar proteins that are critical to ribosome biogenesis and other cellular functions. We show that B23/nucleophosmin, a nucleolar protein that is tightly linked to cancer, is significantly affected by gold nanoparticles. Furthermore, gold nanoparticles impinge on the cellular stress response, as they reduce the abundance of the molecular chaperone hsp70 and O-GlcNAc modified proteins in the nucleus and nucleoli. Together, our studies set the stage for the development of nanomedicines that target the nucleolus to eradicate proliferating cancer cells.

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Roychoudhury, Piya, Aleksandra Golubeva, Przemysław Dąbek, Michał Gloc, Renata Dobrucka, Krzysztof Kurzydłowski, and Andrzej Witkowski. "Diatom Mediated Production of Fluorescent Flower Shaped Silver-Silica Nanohybrid." Materials 14, no. 23 (November 28, 2021): 7284. http://dx.doi.org/10.3390/ma14237284.

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Fabrication of flower-like nanostructures are gaining attention because of their high surface/volume ratio and extensive adsorption capacity. In the present investigation, flower-shaped, autofluorescent silver-silica (Ag-SiO2) hybrid nanoparticles have been fabricated exploiting diatoms as a source of nanosilica. Two different species of Gedaniella including G. flavovirens and G. mutabilis showed their efficacy in synthesizing fluorescent Ag-SiO2 nanoflowers (NFs) and nanospheres (NSs) against 9 mM silver nitrate solution, respectively. The biogenic nanoconjugate (Ag-SiO2) was characterized by Uv-vis spectroscopy, energy dispersive X-ray spectroscopy (EDS), scanning (SEM) and transmission (TEM) electron microscopy. Production of Ag-SiO2 hybrid nanoparticle was confirmed by observing both Ag and Si signals from a single nanoparticle in an EDS study. The broad and single absorption band at ~420 nm in Uv-vis spectroscopy confirmed proper miscibility and production of hybrid nanoparticles. The Ag-SiO2 nanohybrids revealed autofluorescent property under the blue light region (excitation ~450–490 nm). SEM images of particles synthesized by G. flavovirens revealed the production of microscopic flower shaped Ag-SiO2 particles with several layers of petals. A TEM study confirmed that the synthesized Ag-SiO2 NFs are variable in size with 100–500 nm in diameter. Decolorization of methylene blue after exposure to Ag-SiO2 particles confirmed catalytic activity of synthesized nanostructures. This eco-friendly method provides a new dimension in nanobiotechnology for biogenesis of such hierarchical nanostructure in a cost-effective way.

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Murray, Matthew, Yazhe Wang, Ranjini K. Sundaram, Jason Beckta, W. Mark Saltzman, and Ranjit S. Bindra. "Abstract 294: Exploiting mutant PPM1D-induced metabolic defects with nanoparticle-encapsulated NAMPT inhibitors." Cancer Research 82, no. 12_Supplement (June 15, 2022): 294. http://dx.doi.org/10.1158/1538-7445.am2022-294.

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Abstract Diffuse Intrinsic Pontine Glioma (DIPG) is a leading cause of death in pediatric cancer, with an abysmal <1% 5-year survival rate due to lack of effective treatment options. A significant effort is needed to understand the genetic landscape of this disease to develop novel therapeutic strategies and modalities. Recently, the Bindra laboratory found that a truncation mutation in the gene PPM1D, found in ~30% of DIPG cases, causes global epigenetic alterations that lead to therapeutic vulnerabilities. They found that mutant PPM1D activity results in loss of the NAD+ biogenesis protein NAPRT that can be therapeutically targeted by inhibitors of another protein in the NAD+ biogenesis pathway NAMPT (NAMPTi), providing a viable therapeutic strategy for these cancers. Some NAMPTis have been FDA-approved for clinical usage, but present with systemic and retinal toxicity. Moreover, while there are few NAMPTis that can pass the blood brain barrier through systemic delivery, studies show diminished concentrations at the target site. Together, current studies show that the use of NAMPTis for precision targeting of CNS cancers such as DIPG with mutant PPM1D status is a promising therapeutic strategy, but impractical given the limitations of these drugs. However, recent developments in drug delivery systems offer a chance to overcome these issues. Tools such as nanoparticle (NP) drug delivery and unique injection set-ups such as convection-enhanced delivery (CED) allow for drugs such as NAMPTis to be reconsidered for clinical usage. To circumvent the challenges presented by these drugs, we have developed and characterized nanoparticles that encapsulate NAMPTis (NAMPTi-NP) and use CED for sustained intratumoral delivery. Thus far, we have fabricated and optimized PLA-PEG copolymeric nanoparticles capable of encapsulating the NAMPTi, GMX-1778. We characterized these nanoparticles based on (1) hydrodynamic diameter, (2) zeta potential, and (3) stability within an artificial cerebrospinal fluid in vitro solution. We have performed both in vitro and in vivo assays to determine the functionality of the NAMPTi-NPs through (1) cellular uptake studies via immunofluorescence and flow cytometry, (2) functional analysis via NAD+ quantification, (3) short- and long-term cell viability assays to determine sensitivity to the NAMPTi-NP, and (4) in vivo biodistribution studies to assess sustained retention of NAMPTi-NP with CED intracranial injections. We find that NAMPTi-NPs have immediate and sustained cellular uptake, loss of NAD+ post-treatment indicating effective targeting, and enhanced sensitivity in long-term viability studies in mutant PPM1D models. Lastly, these NAMPTi-NPs display prolonged retention in brain tissue compared to free drug injection over time. With further in vivo validation, this NP-based strategy will be a powerful tool for targeting mutant PPM1D DIPG and other cancers. Citation Format: Matthew Murray, Yazhe Wang, Ranjini K. Sundaram, Jason Beckta, W. Mark Saltzman, Ranjit S. Bindra. Exploiting mutant PPM1D-induced metabolic defects with nanoparticle-encapsulated NAMPT inhibitors [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 294.

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Sancho-Albero, María, Maria del Mar Encabo-Berzosa, Manuel Beltrán-Visiedo, Lola Fernández-Messina, Víctor Sebastián, Francisco Sánchez-Madrid, Manuel Arruebo, Jesús Santamaría, and Pilar Martín-Duque. "Efficient encapsulation of theranostic nanoparticles in cell-derived exosomes: leveraging the exosomal biogenesis pathway to obtain hollow gold nanoparticle-hybrids." Nanoscale 11, no. 40 (2019): 18825–36. http://dx.doi.org/10.1039/c9nr06183e.

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Arasi, Maria Beatrice, Francesca Pedini, Sonia Valentini, Nadia Felli, and Federica Felicetti. "Advances in Natural or Synthetic Nanoparticles for Metastatic Melanoma Therapy and Diagnosis." Cancers 12, no. 10 (October 9, 2020): 2893. http://dx.doi.org/10.3390/cancers12102893.

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Advanced melanoma is still a major challenge in oncology. In the early stages, melanoma can be treated successfully with surgery and the survival rate is high, nevertheless the survival rate drops drastically after metastasis dissemination. The identification of parameters predictive of the prognosis to support clinical decisions and of new efficacious therapies are important to ensure patients the best possible prognosis. Recent progress in nanotechnology allowed the development of nanoparticles able to protect drugs from degradation and to deliver the drug to the tumor. Modification of the nanoparticle surface by specific molecules improves retention and accumulation in the target tissue. In this review, we describe the potential role of nanoparticles in advanced melanoma treatment and discuss the current efforts of designing polymeric nanoparticles for controlled drug release at the site upon injection. In addition, we highlight the advances as well as the challenges of exosome-based nanocarriers as drug vehicles. We place special focus on the advantages of these natural nanocarriers in delivering various cargoes in advanced melanoma treatment. We also describe the current advances in knowledge of melanoma-related exosomes, including their biogenesis, molecular contents and biological functions, focusing our attention on their utilization for early diagnosis and prognosis in melanoma disease.

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Babu, B. Hari, and G. Vijaya Lakshmi. "Antibacterial, Anticancer, Catalytic and Antioxidant Activities of Green Synthesized Silver Nanoparticles Derived from Alternanthera sessilis Leaf Extract." Asian Journal of Chemistry 34, no. 12 (2022): 3286–92. http://dx.doi.org/10.14233/ajchem.2022.23980.

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The current study evaluates the biogenesis of silver nanoparticles (Ag NPs) utilizing an aqueous extract of Alternanthera sessilis (Linn.) leaf. Biological nanoparticle production has recently gained appeal due to its eco-friendliness, simplicity, cost-effectiveness, non-hazardous nature and difficult circumstances. Aqueous extract of Alternanthera sessilis leaf contains terpenoids, carbohydrates and flavonoids to convert metal ions into metal and so stabilize the resultant nanoparticles. The UV-visible spectrophotometer obtained a distinctive peak at 420 nm, the XRD validated the crystalline FCC nature of biogenic Ag NPs and the FTIR and zeta-potential (± 14) tests revealed that phyto-chemicals were responsible for reduction and stabilization of Ag NPs. TEM examination revealed a spherical form and size of about 24 nm. The biogenic Ag NPs displayed intriguing dose-dependent antioxidant activity, with an EC50 percent of 69.9g/mL and a maximum activity of 66.36 at 150 μg/mL against DPPH, as well as considerable catalytic activity against Eosin-Y red dye, 84% of Eosin-Y dye destroyed after 60 min. Furthermore, the experiments demonstrated that Ag NPs were more effective against Gram-negative bacteria than Gram-positive bacteria and also show the anticancer activity against Hela cells and breast cancer cell line (MCF-7).The anticancer activity is more potent in higher concentrations.

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Shaw, S., P. Singh, R. Mishra, R. Singh, R. Nayak, and S. Bose. "Cancer therapeutics strategy using nano-carrier mediated natural drugs." Journal of Achievements in Materials and Manufacturing Engineering 114, no. 1 (September 1, 2022): 32–41. http://dx.doi.org/10.5604/01.3001.0016.1481.

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Nucleolin is a multifactorial protein, having a significant role in chromatin remodelling, mRNA stability, ribosome biogenesis, stemness, angiogenesis, etc., thus, it is potential therapeutic target in cancer. The purpose of this paper is to study porous silicon (pSi) nanocarrier-based natural drug delivery system targeting dysregulated nucleolin expression for cancer therapeutics. Quercetin was loaded in pre-synthesized and characterized pSi nanoparticles, and release kinetics was studied. The study compared the inhibitory concentration (IC50) of quercetin, synthetic drug doxorubicin, and quercetin-loaded pSi nanoparticles. Further, mRNA expression of a target gene, nucleolin, was tested with a quercetin treated breast cancer cell line (MCF-7). Quercetin-loaded pSi nanoparticles followed first-order release kinetics. IC50 was determined at concentrations of 312 nM, 160 µM, and 50 µM against doxorubicin, quercetin, and quercetin-loaded pSi nanoparticles, respectively. The results further indicated 16-fold downregulation of nucleolin mRNA expression after 48h of quercetin treatment of exponentially growing MCF-7 cells. Whether pSi nanoparticle loaded quercetin can significantly downregulate nucleolin protein expression and its impact on apoptosis, cell proliferation, and angiogenic pathways need further investigation. The practical application of the proposed nanocarrier-based drug delivery system potentially lays out a path for developing targeted therapy against nucleolin-dysregulated cancer using natural products to minimize the side effects of conventional chemotherapeutic drugs. Inhibition of nucleolin and nucleolin regulated pathways using natural compounds and its targeted delivery with nanocarrier is not yet done.

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Huang, Di, Naagarajan Narayanan, Mario A. Cano-Vega, Zhihao Jia, Kolapo M. Ajuwon, Shihuan Kuang, and Meng Deng. "Nanoparticle-Mediated Inhibition of Notch Signaling Promotes Mitochondrial Biogenesis and Reduces Subcutaneous Adipose Tissue Expansion in Pigs." iScience 23, no. 6 (June 2020): 101167. http://dx.doi.org/10.1016/j.isci.2020.101167.

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Kumar, Sanjay, Brennetta J. Crenshaw, Sparkle D. Williams, Courtnee’ R. Bell, Qiana L. Matthews, and Brian Sims. "Cocaine‐Specific Effects on Exosome Biogenesis in Microglial Cells." Neurochemical Research 46, no. 4 (February 8, 2021): 1006–18. http://dx.doi.org/10.1007/s11064-021-03231-2.

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AbstractCocaine is a highly addictive stimulant and a well-known drug, with multiple effects on physiology. Cocaine can have direct effects on all cell types in the brain, including microglia. Microglia can be activated by other conditions, such as infection, inflammation, or injury. However, how cocaine regulates microglia and the influence of cocaine on microglial-derived exosomes remains unknown. Exosomes are nanovesicles that are responsible for intercellular communications, signaling, and trafficking necessary cargo for cell homeostasis. In this study, we hypothesized that cocaine affects exosome biogenesis and composition in BV2 microglial cells. BV2 microglial cells were cultured in exosome-depleted RPMI-1640 media and were treated according to the experimental designs. We observed that cell viability decreased by 11% at 100 µM cocaine treatment but was unaffected at other concentrations. After treatments, the exosomes were isolated from the condition media. Purified exosomes were characterized and quantified using transmission electron microscope (TEM) and nanoparticle tracking analysis (NTA). By NTA, there was a significant decrease in particles/mL after cocaine treatment. There was a 39.5%, 58.1%, 32.3% and 28.1% decrease in particles/mL at 100 nM, 1 μM, 10 μM and 100 μM cocaine, respectively. The characterization of exosomes and exosomal protein was performed by western/dot blot analyses. Tetraspanins CD11b, CD18 and CD63 were relatively unchanged after cocaine treatment. The heat shock proteins (Hsps), Hsp70 and Hsp90, were both significantly increased at 10 μM and 100 μM, but only hsp70 was significantly increased at 10 nM. The Rab proteins were assessed to investigate their role in cocaine-mediated exosomal decrease. Rab11 was significantly decreased at 10 nM, 100 nM, 1 μM, 10 μM and 100 μM by 15%, 28%, 25%, 38% and 22%, respectively. Rab27 was decreased at all concentrations but only significantly decreased at 100 nM, 1 μM and 100 μM cocaine by 21%, 24% and 23%, respectively. Rab35 had no significant changes noted when compared to control. Rab7 increased at all cocaine concentrations but only a significant increase in expression at 100 nM and 10 μM by 1.32-fold and 1.4-fold increase. Cocaine was found to alter exosome biogenesis and composition in BV2 microglial cells. Western and dot blot analyses verified the identities of purified exosomes, and the specific protein compositions of exosomes were found to change in the presence of cocaine. Furthermore, cocaine exposure modulated the expression of exosomal proteins, such as Hsps and Rab GTPases, suggesting the protein composition and formation of microglial-derived exosomes were regulated by cocaine.

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Більше джерел

Дисертації з теми "Nanoparticle biogenesis"

Ho, Nicholas Ryan. "Controlling gold nanoparticle biogenesis in the bacterium enterobacter sp. Pb204." Thesis, 2018. https://hdl.handle.net/10539/26698.

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A dissertation submitted to the Faculty of Science of the University of Witwatersrand, Johannesburg, in full fulfilment of the requirements for the degree of Master of Science, 2018
Research into the synthesis of gold nanoparticles (AuNPs) has increased in the past few decades due to their wide range of potential applications, with increased emphasis placed on the greener synthesis of AuNPs. A promising method of synthesis is bacterial synthesis but one of the largest obstacles faced by this method is the large variability in the shape and size of AuNPs. To this end, the aim of this study was to improve the uniformity of AuNPs synthesised by a bacterium isolated from acid mine decant on the West Rand of Gauteng, South Africa, (26°06'26.8"S 27°43'20.2"E) (Enterobacter sp. Pb204) through alteration of reaction parameters as well as the determination of possible genetic pathways responsible for AuNP synthesis. The following reaction parameters: growth media, biocatalyst ratio, temperature, pH and gold ion concentration were altered to determine their influence on AuNP synthesis by Enterobacter sp. Pb204. The AuNPs were analysed using ultravioletvisible spectroscopy, transmission electron microscopy and energy-dispersive X-ray spectroscopy. Following the optimisation of AuNP biogenesis in Enterobacter sp. Pb204, the whole genome of the bacterium was sequenced using the Illumina Hiseq (2500, California, USA). To produce uniformed spherical AuNPs, within a size range of 2 to 15 nm, the following parameters were identified: cell biocatalyst grown LB at a pH of 3, incubated at 37 °C with a chloroauric acid concentration of 1 mM for 24 hours. The whole genome analysis of Enterobacter sp. Pb204 revealed that it is a unique strain of Enterobacter xiangfangensis LMG 27195T and was therefore named E. xiangfangensis Pb204. Further analysis of E. xiangfangensis Pb204’s genome revealed that it possessed several unique metal resistance genes not found in the type strain. The majority of these genes were found on an integrated conjugative element (ICE). The presence of the ICE element, with the extra cargo genes, in E. xiangfangensis Pb204 may play a role in AuNP synthesis.
XL2019

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Частини книг з теми "Nanoparticle biogenesis"

Deepak, Venkataraman, Kalimuthu Kalishwaralal, Sureshbabu Ram Kumar Pandian, and Sangiliyandi Gurunathan. "An Insight into the Bacterial Biogenesis of Silver Nanoparticles, Industrial Production and Scale-up." In Metal Nanoparticles in Microbiology, 17–35. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-18312-6_2.

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Nahvi, Insha, Sana Belkahla, Sarah Mousa Asiri, and Suriya Rehman. "Overview and Prospectus of Algal Biogenesis of Nanoparticles." In Microbial Nanotechnology: Green Synthesis and Applications, 121–34. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-16-1923-6_7.

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Yanes, Rolando E., Jie Lu, and Fuyuhiko Tamanoi. "Nanoparticle-Based Delivery of siRNA and miRNA for Cancer Therapy." In Eukaryotic RNases and their Partners in RNA Degradation and Biogenesis, Part B, 185–203. Elsevier, 2012. http://dx.doi.org/10.1016/b978-0-12-404741-9.00009-x.

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Mungali, Manjul, Amit Kumar, and Nisha Malik. "Green Synthesis Technology (GST)." In Handbook of Research on Green Technologies for Sustainable Management of Agricultural Resources, 180–87. IGI Global, 2022. http://dx.doi.org/10.4018/978-1-7998-8434-7.ch011.

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Nanotechnology offers new materials and applications that will benefit society, yet there is growing concern about the potential health and environmental impacts of the production and use of nanoscale products. Although hundreds of studies of nanomaterial hazards have been reported, in green nanotechnology, nanomaterials or nanoparticles are synthesized or developed by biological approaches, such as biogenesis (biosynthesis) that has vast applications in the biomedical, food, and agricultural fields. Additionally, green nanotechnology offers many potential benefits, such as the enhancement of biomedical diagnostics, improved food quality and safety, reduction of agricultural inputs, and enrichment of nanoscale nutrient absorption from the soil. The green synthesis method, which is an alternative to chemical and physical methods, provides an eco-friendly way of synthesizing nanoparticles as this method does not require costly, harmful, and toxic chemicals.

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Mariappan, Yazhiniprabha, Vinotha Viswanathan, and Vaseeharan Baskaralingam. "Culinary spices mediated biogenesis of nanoparticles for cancer and diabetes treatment." In Fundamentals of Bionanomaterials, 59–76. Elsevier, 2022. http://dx.doi.org/10.1016/b978-0-12-824147-9.00003-0.

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Maurizi, Lionel, Anne-Laure Papa, Julien Boudon, Sruthi Sudhakaran, Benoist Pruvot, David Vandroux, Johanna Chluba, Gérard Lizard, and Nadine Millot. "Toxicological Risk Assessment of Emerging Nanomaterials: Cytotoxicity, Cellular Uptake, Effects on Biogenesis and Cell Organelle Activity, Acute Toxicity and Biodistribution of Oxide Nanoparticles." In Unraveling the Safety Profile of Nanoscale Particles and Materials - From Biomedical to Environmental Applications. InTech, 2018. http://dx.doi.org/10.5772/intechopen.71833.

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