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Автор: Grafiati

Опубліковано: 11 вересня 2023

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1

Odermatt, Reto, Matej Par, Dirk Mohn, Daniel B. Wiedemeier, Thomas Attin, and Tobias T. Tauböck. "Bioactivity and Physico-Chemical Properties of Dental Composites Functionalized with Nano- vs. Micro-Sized Bioactive Glass." Journal of Clinical Medicine 9, no. 3 (March 12, 2020): 772. http://dx.doi.org/10.3390/jcm9030772.

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Анотація:

Bioactive resin composites can contribute to the prevention of secondary caries, which is one of the main reasons for failure of contemporary dental restorations. This study investigated the effect of particle size of bioactive glass 45S5 on chemical and physical composite properties. Four experimental composites were prepared by admixing the following fillers into a commercial flowable composite: (1) 15 wt% of micro-sized bioactive glass, (2) 15 wt% of nano-sized bioactive glass, (3) a combination of micro- (7.5 wt%) and nano-sized (7.5 wt%) bioactive glass, and (4) 15 wt% of micro-sized inert barium glass. Hydroxyapatite precipitation and pH rise in phosphate-buffered saline were evaluated during 28 days. Degree of conversion and Knoop microhardness were measured 24 h after specimen preparation and after 28 days of phosphate-buffered saline immersion. Data were analyzed using non-parametric statistics (Kruskal–Wallis and Wilcoxon tests) at an overall level of significance of 5%. Downsizing the bioactive glass particles from micro- to nano-size considerably improved their capability to increase pH. The effect of nano-sized bioactive glass on degree of conversion and Knoop microhardness was similar to that of micro-sized bioactive glass. Composites containing nano-sized bioactive glass formed a more uniform hydroxyapatite layer after phosphate-buffered saline immersion than composites containing exclusively micro-sized particles. Partial replacement of nano- by micro-sized bioactive glass in the hybrid composite did not impair its reactivity, degree of conversion (p > 0.05), and Knoop microhardness (p > 0.05). It is concluded that downsizing bioactive glass particles to nano-size improves the alkalizing potential of experimental composites with no negative effects on their fundamental properties.

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2

Nabian, Nima, Maedeh Delavar, Mahmood Rabiee, and Mohsen Jahanshahi. "Quenched/unquenched nano bioactive glass-ceramics: Synthesis and in vitro bioactivity evaluation in Ringer’s solution with BSA." Chemical Industry and Chemical Engineering Quarterly 19, no. 2 (2013): 231–39. http://dx.doi.org/10.2298/ciceq120323057n.

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The paper reports the first attempt at changing cooling treatment of synthesizing method in order to investigate its effect on the physical properties of sol-gel derived nano bioactive glass-ceramic in the system 58SiO2-33CaO-9P2O5 (wt.%). We hypothesized that the method of cooling may affect the properties of nano bioactive glass-ceramic. To test this hypothesis, two different method of cooling treatment was applied after calcinations in synthesizing method. Both quenched and unquenched nano bioactive glass-ceramics were soaked in Ringer?s solution with bovine serum albumin (BSA) for bioactivity evaluation. The obtained samples were analyzed for their composition, crystalinity and morphology through X-ray powder diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), surface electron microscope (SEM) and transmission electron microscope (TEM). The SEM images showed that the morphology of nano bioactive glass-ceramics was completely changed by quenching process. Results of in vitro bioactivity evaluation revealed that the unquenched attains faster apatite formation ability than the quenched sample. Other properties of these two morphologically different nano bioactive glass-ceramics were strongly discussed.

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3

Al-Sayed, Fatema Aziz, Radwa Hamed Hegazy, Zeinab Amin Salem, and Hanan Hassan El-Beheiry. "COMBINED USE OF HYALURONIC ACID WITH NANO-BIOACTIVE GLASS ENHANCED BIOCEMENT BASED SILICATE STIMULATED BONE REGENERATIVE CAPACITY IN TIBIAL BONE DEFECTS OF RABBITS: IN-VIVO STUDY." Journal of Experimental Biology and Agricultural Sciences 9, no. 5 (October 30, 2021): 630–38. http://dx.doi.org/10.18006/2021.9(5).630.638.

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An ideal biomaterial for bone regeneration is a longstanding quest nowadays. This study aimed to evaluate the osteogenic potentiality of nano-bioactive glass enhanced biocement based silicate with or without hyaluronic acid seeded in rabbits’ tibial bone defects. For this, 24 male rabbits with two 5 mm defects (1 defect per tibia) were divided into three equal groups. Among the predefined three groups, for the rabbits of group 1(control) bone defects were left untreated while for the members of group 2 defects received nano-bioactive glass enhanced biocement based silicate cement, and group 3 defects received nano-bioactive glass cement mixed with hyaluronic acid. Animals of each group were divided equally for euthanization after 3 and 6 weeks. Bone specimens were processed and examined histologically with histomorphometrically analysis of new bone area percentage. The bone defects in group 3 showed significantly improved osseous healing histologically as compared to the group 1&2. The morphometric analysis also revealed a significant increase in the new bone area percentage in group 3 as compared to the group 1 and 2 (P < 0.05). The results of the present study can be concluded that bone defects could be treated with nano-bioactive glass and hyaluronic acid cement. Although, nano-bioactive glass alone was capable of bone regeneration the combination of both had significant regenerative capacity.

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4

Anitha, D. R., and P. Jayashri. "Nano Structured Bioactive Glass on Dental Disease." Indian Journal of Public Health Research & Development 10, no. 11 (2019): 3459. http://dx.doi.org/10.5958/0976-5506.2019.04118.4.

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5

Nawaz, Qaisar, Araceli de Pablos-Martín, Lutz Berthold, Juliana Martins de Souza e Silva, Katrin Hurle, and Aldo R. Boccaccini. "Mapping the elemental and crystalline phase distribution in Cu²⁺ doped 45S5 bioactive glass upon crystallization." CrystEngComm 24, no. 2 (2022): 284–93. http://dx.doi.org/10.1039/d1ce01160j.

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Анотація:

Nano-CT and TEM imaging characterisation of Cu-doped 45S5 glass-ceramics. The grain size and content of Cu-riched glassy phase, which affect bioactive and mechanical responses, can be tuned by heat treatment.

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6

Waltimo, T., T. J. Brunner, M. Vollenweider, W. J. Stark, and M. Zehnder. "Antimicrobial Effect of Nanometric Bioactive Glass 45S5." Journal of Dental Research 86, no. 8 (August 2007): 754–57. http://dx.doi.org/10.1177/154405910708600813.

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Анотація:

Most recent advances in nanomaterials fabrication have given access to complex materials such as SiO2-Na2O-CaO-P2O5 bioactive glasses in the form of amorphous nanoparticles of 20- to 60-nm size. The clinically interesting antimicrobial properties of commercially available, micron-sized bioactive glass 45S5 have been attributed to the continuous liberation of alkaline species during application. Here, we tested the hypothesis that, based on its more than ten-fold higher specific surface area, nanometric bioactive glass releases more alkaline species, and consequently displays a stronger antimicrobial effect, than the currently applied micron-sized material. Ionic dissolution profiles were monitored in simulated body fluid. Antimicrobial efficacy was assessed against clinical isolates of enterococci from persisting root canal infections. The shift from micron- to nano-sized treatment materials afforded a ten-fold increase in silica release and solution pH elevation by more than three units. Furthermore, the killing efficacy was substantially higher with the new material against all tested strains.

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7

Aguilar-Pérez, Fernando J., Rossana F. Vargas-Coronado, Jose M. Cervantes-Uc, Juan V. Cauich-Rodríguez, Cristian Covarrubias, and Merhdad Pedram-Yazdani. "Preparation and bioactive properties of nano bioactive glass and segmented polyurethane composites." Journal of Biomaterials Applications 30, no. 9 (January 14, 2016): 1362–72. http://dx.doi.org/10.1177/0885328215626361.

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8

Rocton, N., H. Oudadesse, S. Mosbahi, L. Bunetel, P. Pellen-Mussi, and B. Lefeuvre. "Study of nano bioactive glass for use as bone biomaterial comparison with micro bioactive glass behaviour." IOP Conference Series: Materials Science and Engineering 628 (October 8, 2019): 012005. http://dx.doi.org/10.1088/1757-899x/628/1/012005.

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9

Moawad, H. M. M., and H. Jain. "Development of nano-macroporous soda-lime phosphofluorosilicate bioactive glass and glass-ceramics." Journal of Materials Science: Materials in Medicine 20, no. 7 (February 28, 2009): 1409–18. http://dx.doi.org/10.1007/s10856-009-3711-7.

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10

Sarmast Sh, M., S. George, A. B. Dayang Radiah, D. Hoey, N. Abdullah, and S. Kamarudin. "Synthesis of bioactive glass using cellulose nano fibre template." Journal of the Mechanical Behavior of Biomedical Materials 130 (June 2022): 105174. http://dx.doi.org/10.1016/j.jmbbm.2022.105174.

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11

Sarmast Sh, M., S. George, C. AB Dayang Radiah, N. Abdullah, and S. Kamarudin. "Synthesis of Bioactive Glass using Cellulose Nano Fibre Template." IOP Conference Series: Materials Science and Engineering 778 (May 1, 2020): 012042. http://dx.doi.org/10.1088/1757-899x/778/1/012042.

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12

Vadera, Nikhil, Anusha Ashokan, Genekehal S. Gowd, K. M. Sajesh, R. P. Chauhan, R. Jayakumar, Shantikumar V. Nair, and Manzoor Koyakutty. "Manganese doped nano-bioactive glass for magnetic resonance imaging." Materials Letters 160 (December 2015): 335–38. http://dx.doi.org/10.1016/j.matlet.2015.07.158.

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13

Mitchell, John C., Lawrence Musanje, and Jack L. Ferracane. "Biomimetic dentin desensitizer based on nano-structured bioactive glass." Dental Materials 27, no. 4 (April 2011): 386–93. http://dx.doi.org/10.1016/j.dental.2010.11.019.

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14

Sheng, Xu-Yan, Wei-Yu Gong, Qing Hu, Xiao-feng Chen, and Yan-Mei Dong. "Mineral formation on dentin induced by nano-bioactive glass." Chinese Chemical Letters 27, no. 9 (September 2016): 1509–14. http://dx.doi.org/10.1016/j.cclet.2016.03.030.

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15

Desouky, Asmaa A., Maged M. Negm, and Magdy M. Ali. "Sealability of Different Root Canal Nanosealers: Nano Calcium Hydroxide and Nano Bioactive Glass." Open Dentistry Journal 13, no. 1 (August 30, 2019): 308–15. http://dx.doi.org/10.2174/1874210601913010308.

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Анотація:

Background: The success of the endodontic treatment is largely dependent on the sealing achieved by root canal obturation. The application of sealer fills imperfections and increases adaptation of the root filling to the canal walls. Aim: To evaluate the sealability of experimental nanosealers (nano calcium hydroxide and nano bioactive glass) and to compare it with the commercial zinc oxide eugenol sealer using a dye penetration method. Materials and Methods: Sixty single-rooted mandibular premolars were selected. The tooth crowns were removed so as to obtain standardized 15-mm-long root specimens. The root canal was instrumented with Protaper Ni-Ti rotary file and the final file size was up to # F4/.06 (in vitro study). They were then randomly allocated into 3 groups of 20 specimens each (n=20) according to the sealer used for obturation, and all samples were filled with single cone gutta-percha (#40/06) and one of the tested sealers. All teeth were coated with nail polish and then suspended in 2% methylene blue dye for 7 days. Stereo-microscope (x10) was used to evaluate the sealability of newly introduced nanosealers. The data were statistically analyzed by ANOVA test followed by post hoc analysis (P < 0.05). Results: Significant improvement shown by the presented study suggests that nano calcium hydroxide sealer showed significantly less dye leakage than nano bioactive glass sealer and zinc oxide eugenol sealer. Conclusion: The results of this study showed that the synthesized nano-powder sealers are suitable for use in root canal therapy to prevent leakage. The root canal can be sealed better by using smaller nano-powder particle sizes. In addition, the two groups exhibited significant differences in leakage in comparison with commonly used ZOE sealer.

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16

Przybylowski, Colin, Mohamed Ammar, Courtney LeBlon, and Sabrina S. Jedlicka. "Osteogenesis of MC3T3 Preosteoblasts on 3D Bioactive Peptide Modified Nano-Macroporous Bioactive Glass Scaffolds." Journal of Biomaterials and Nanobiotechnology 06, no. 03 (2015): 146–59. http://dx.doi.org/10.4236/jbnb.2015.63015.

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17

Bafandeh, Mohammad Reza, Raziyeh Gharahkhani, and Mohammad Hossein Fathi. "Characterization of fabricated cobalt-based alloy/nano bioactive glass composites." Materials Science and Engineering: C 69 (December 2016): 692–99. http://dx.doi.org/10.1016/j.msec.2016.07.053.

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18

Goh, Yi-Fan, Ammar Z. Alshemary, Muhammad Akram, Mohammed Rafiq Abdul Kadir, and Rafaqat Hussain. "In vitro study of nano-sized zinc doped bioactive glass." Materials Chemistry and Physics 137, no. 3 (January 2013): 1031–38. http://dx.doi.org/10.1016/j.matchemphys.2012.11.022.

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19

Misra, Superb K., Tahera Ansari, Dirk Mohn, Sabeel P. Valappil, Tobias J. Brunner, Wendelin J. Stark, Ipsita Roy, et al. "Effect of nanoparticulate bioactive glass particles on bioactivity and cytocompatibility of poly(3-hydroxybutyrate) composites." Journal of The Royal Society Interface 7, no. 44 (July 29, 2009): 453–65. http://dx.doi.org/10.1098/rsif.2009.0255.

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Анотація:

This work investigated the effect of adding nanoparticulate (29 nm) bioactive glass particles on the bioactivity, degradation and in vitro cytocompatibility of poly(3-hydroxybutyrate) (P(3HB)) composites/nano-sized bioactive glass (n-BG). Two different concentrations (10 and 20 wt %) of nanoscale bioactive glass particles of 45S5 Bioglass composition were used to prepare composite films. Several techniques (Raman spectroscopy, scanning electron microscopy, atomic force microscopy, energy dispersive X-ray) were used to monitor their surface and bioreactivity over a 45-day period of immersion in simulated body fluid (SBF). All results suggested the P(3HB)/n-BG composites to be highly bioactive, confirmed by the formation of hydroxyapatite on material surfaces upon immersion in SBF. The weight loss and water uptake were found to increase on increasing bioactive glass content. Cytocompatibility study (cell proliferation, cell attachment, alkaline phosphatase activity and osteocalcin production) using human MG-63 osteoblast-like cells in osteogenic and non-osteogenic medium showed that the composite substrates are suitable for cell attachment, proliferation and differentiation.

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20

Cao, Y., B. Yang, C. Gao, P. Feng, and C. Shuai. "Laser sintering of nano 13-93 glass scaffolds: Microstructure, mechanical properties and bioactivity." Science of Sintering 47, no. 1 (2015): 31–39. http://dx.doi.org/10.2298/sos1501031c.

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Анотація:

As the only bioactive material that can bond with both hard tissues and soft tissues, bioactive glass has become much important in the field of tissue engineering. 13-93 bioactive glass scaffolds were fabricated via selective laser sintering (SLS). It was focused on the effects of laser sintering on microstructure and mechanical properties of the scaffolds. The experimental results showed that the sintered layer gradually became dense with the laser power increasing and then some defects occurred, such as macroscopic caves. The optimum compressive strength and fracture toughness were 21.43?0.87 MPa and 1.14?0.09 MPa.m1/2, respectively. In vitro bioactivity showed that there was the bone-like apatite layer on the surface of the scaffolds after soaking in simulated body fluid (SBF), which was further evaluated by Fourier transform infrared spectroscopy (FTIR). Moreover, cell culture study showed MG-63 cells adhered and spread well on the scaffolds, and proliferated with increasing time in cell culture. These indicated excellent bioactivity and biocompatibility of nano 13-93 glass scaffolds.

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21

Gong, Weiyu, Yanmei Dong, Sainan Wang, Xuejun Gao, and Xiaofeng Chen. "A novel nano-sized bioactive glass stimulates osteogenesis via the MAPK pathway." RSC Advances 7, no. 23 (2017): 13760–67. http://dx.doi.org/10.1039/c6ra26713k.

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22

Schumacher, Matthias, Pamela Habibović, and Sabine van Rijt. "Peptide-Modified Nano-Bioactive Glass for Targeted Immobilization of Native VEGF." ACS Applied Materials & Interfaces 14, no. 4 (January 18, 2022): 4959–68. http://dx.doi.org/10.1021/acsami.1c21378.

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23

Najeeb, Shariq, Zohaib Khurshid, Muhammad Zafar, Abdul Khan, Sana Zohaib, Juan Martí, Salvatore Sauro, Jukka Matinlinna, and Ihtesham Rehman. "Modifications in Glass Ionomer Cements: Nano-Sized Fillers and Bioactive Nanoceramics." International Journal of Molecular Sciences 17, no. 7 (July 14, 2016): 1134. http://dx.doi.org/10.3390/ijms17071134.

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24

Farag, M. M., W. M. Abd-Allah, and A. M. Ibrahim. "Effect of gamma irradiation on drug releasing from nano-bioactive glass." Drug Delivery and Translational Research 5, no. 1 (January 16, 2015): 63–73. http://dx.doi.org/10.1007/s13346-014-0214-y.

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25

Deng, Junjie, Pengjian Li, Chengde Gao, Pei Feng, Cijun Shuai, and Shuping Peng. "Bioactivity Improvement of Forsterite-Based Scaffolds with nano-58S Bioactive Glass." Materials and Manufacturing Processes 29, no. 7 (July 3, 2014): 877–84. http://dx.doi.org/10.1080/10426914.2014.921712.

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26

Mozafari, M., F. Moztarzadeh, M. Rabiee, M. Azami, N. Nezafati, Z. Moztarzadeh, and M. Tahriri. "Development of 3D Bioactive Nanocomposite Scaffolds Made from Gelatin and Nano Bioactive Glass for Biomedical Applications." Advanced Composites Letters 19, no. 2 (March 2010): 096369351001900. http://dx.doi.org/10.1177/096369351001900204.

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Анотація:

In this research, macroporous, mechanically competent and bioactive nanocomposite scaffolds have been fabricated from cross-linked gelatine (Gel) and nano bioactive glass (nBG) through layer solvent casting combined with freeze-drying and lamination techniques. This study has developed a new composition to produce a new bioactive nanocomposite which is porous with interconnected microstructure, pore sizes are 200-500 μm, porosity are 72%-86%. Also, we have reported formation of chemical bonds between nBG and Gel for the first time. Finally, the in vitro cytocompatability of the scaffolds was assessed using MTT assay and cell attachment study. Results indicated no sign of toxicity and cells found to be attached to the pore walls offered by the scaffolds. These results suggested that the developed nanocomposite scaffold possess the prerequisites for bone tissue engineering scaffolds and it can be used for tissue engineering applications.

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27

Kytyr, Daniel, Nela Krčmářová, Jan Šleichrt, Tomáš Fíla, Petr Koudelka, Ana Gantar, and Sasa Novak. "DEFORMATION RESPONSE OF GELLAN GUM BASED BONE SCAFFOLD SUBJECTED TO UNIAXIAL QUASI-STATIC LOADING." Acta Polytechnica 57, no. 1 (February 28, 2017): 14–21. http://dx.doi.org/10.14311/ap.2017.57.0014.

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Анотація:

This study is focuses on an investigation of the reinforcement effect of the bioactive glass nano-particles in the gellan gum (GG) scaffolds used in bone tissue engineering. The investigated material was synthesized as the porous spongy-like structure improved by the bioactive glass (BAG) nano-particles. Cylindrical samples were subjected to a uniaxial quasi-static loading in tension and compression. Very soft nature of the material, which makes the sample susceptible to damage, required employment of a custom designed experimental device for the mechanical testing. Moreover, as the mechanical properties are significantly influenced by testing conditions the experiment was performed using dry samples and also using samples immersed in the simulated body fluid. Material properties of the pure GG scaffold and the GG-BAG reinforced scaffold were derived from a set of tensile and compression tests under dry and simulated physiological conditions. The results are represented in the form of stress-strain curves calculated from the acquired force and displacement data.

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28

Thian, E. S., Z. Ahmad, Jie Huang, Mohan J. Edirisinghe, S. N. Jayasinghe, D. C. Ireland, Roger A. Brooks, Neil Rushton, William Bonfield, and Serena Best. "Electrosprayed Nanoapatite: A New Generation of Bioactive Material." Key Engineering Materials 361-363 (November 2007): 597–600. http://dx.doi.org/10.4028/www.scientific.net/kem.361-363.597.

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Анотація:

Fine nanoapatite relics were deposited on glass substrates by electrohydrodynamic atomisation, using nanohydroxyapatite (nHA), nano-carbonated hydroxyapatite (nCHA) and nanosilicon- substituted hydroxyapatite (nSiHA) suspensions. These electrosprayed nanoapatites were evaluated in-vitro using simulated body fluid (SBF) and human osteoblast (HOB) cells. The SBF study revealed that newly-formed apatite layers were observed on the surface of the relics. Furthermore, enhanced HOB cell growth was observed on each of the nanoapatites at all time points. Hence, this work demonstrated that electrosprayed nanoapatites offer considerable potential as biomaterials.

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29

Liu, J., Z. Dong, and X. Miao. "Porous Alumina/Zirconia Composite Scaffold with Bioactive Glass 58S33C Coating." Journal of Biomimetics, Biomaterials and Tissue Engineering 6 (September 2010): 87–104. http://dx.doi.org/10.4028/www.scientific.net/jbbte.6.87.

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Анотація:

Strong and tough, macroporous alumina/zirconia composites are superior to alumina scaffolds but still biologically inert to bone tissue, leading to poor tissue ingrowth and osteointegration. One way to solve this problem is applying a bioactive coating onto the pore walls of the macroporous composites. In this study, macroporous alumina/zirconia (20vol%) composites (scaffolds) were prepared by a vacuum infiltration method involving the use of strained (10%) compacts of the expanded polystyrene (EPS) beads (typically 1-2.8 mm in diameter). A bioactive glass (58S33C) coating (~ 20 μm) was applied on the pore walls of the macroporous composites by slurry dip coating and sintering at 1200 oC for 1 hour. A top or outer bioactive glass (58S33C) thin layer (< 10 μm) was further applied by sol dip coating and sintering at a low temperature (< 800 °C). The bioactive glass-coated macroporous alumina/zirconia composites had well interconnected pores, relatively large pore sizes (1-2 mm), medium porosities (60-66%), high compressive strengths (7.52 – 5.42 MPa), and high bioactivity (with an apatite layer formed within 24 hours in the simulated body fluid). The combination of the strong and ultrafine (if not nano-structured) macroporous scaffolds with the multiple or graded bioactive coatings represented a new generation of bone substitutes or permanent scaffolds for bone tissue regeneration.

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30

Gupta, Nidhi, and Deenan Santhiya. "Role of cellulose functionality in bio-inspired synthesis of nano bioactive glass." Materials Science and Engineering: C 75 (June 2017): 1206–13. http://dx.doi.org/10.1016/j.msec.2017.03.026.

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31

Srinivasan, Sowmya, R. Jayasree, K. P. Chennazhi, S. V. Nair, and R. Jayakumar. "Biocompatible alginate/nano bioactive glass ceramic composite scaffolds for periodontal tissue regeneration." Carbohydrate Polymers 87, no. 1 (January 2012): 274–83. http://dx.doi.org/10.1016/j.carbpol.2011.07.058.

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32

Sohrabi, Mehri, Bijan Eftekhari Yekta, Hamid R. Rezaie, and Mohammad R. Naimi‐Jamal. "Rheology, injectability, and bioactivity of bioactive glass containing chitosan/gelatin, nano pastes." Journal of Applied Polymer Science 137, no. 41 (March 17, 2020): 49240. http://dx.doi.org/10.1002/app.49240.

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33

Xue, Ming, Jun Ou, Da Li Zhou, Dange Feng, Wei Zhong Yang, Guanda Li, Dan Ping Liu, and Yan Song Wang. "Preparation and Properties of Porous Apatite-Wollastonite Bioactive Glass-Ceramic." Key Engineering Materials 330-332 (February 2007): 169–72. http://dx.doi.org/10.4028/www.scientific.net/kem.330-332.169.

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Анотація:

The porous apatite-wollastonite bioactive glass-ceramic (AW-GG) was made from nano-precursor powders derived from sol-gel process, and shaped by dipping method with polymer foam. The physical-chemical properties, bioactivity and biocompatibility of the materials were studied by means of TG, XRD, SEM, TEM and so on. The bioactivity was investigated in simulated body fluid (SBF) and the biocompatibility was evaluated by co-culturing with marrow stromal cells (MSCs). The result shows that: the particle size of the AW precursor powders is 40~100nm; porous AW GC has three-dimensional pored structure with 300~500um macropores and 2~5um micropores; the materials possess high bioactivity and biocompatibility. Porous AW GC may therefore have great potential application as bone tissue engineering scaffold.

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34

Soundrapandian, Chidambaram, Sanghamitra Bharati, Debabrata Basu, and Someswar Datta. "Studies on novel bioactive glasses and bioactive glass–nano-HAp composites suitable for coating on metallic implants." Ceramics International 37, no. 3 (April 2011): 759–69. http://dx.doi.org/10.1016/j.ceramint.2010.10.025.

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Li, X., J. Huang, and M. J. Edirisinghe. "Novel patterning of nano-bioceramics: template-assisted electrohydrodynamic atomization spraying." Journal of The Royal Society Interface 5, no. 19 (August 16, 2007): 253–57. http://dx.doi.org/10.1098/rsif.2007.1162.

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Анотація:

The ability to create patterns of bioactive nanomaterials particularly on metallic and other types of implant surfaces is a crucial feature in influencing cell response, adhesion and growth. In this report, we uncover and elucidate a novel method that allows the easy deposition of a wide variety of predetermined topographical geometries of nanoparticles of a bioactive material on both metallic and non-metallic surfaces. Using different mesh sizes and geometries of a gold template, hydroxyapatite nanoparticles suspended in ethanol have been electrohydrodynamically sprayed on titanium and glass substrates under carefully designed electric field conditions. Thus, different topographies, e.g. hexagonal, line and square, from hydroxyapatite nanoparticles were created on these substrates. The thickness of the topography can be controlled by varying the spraying time.

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Ilyas, Kanwal, Lamia Singer, Muhammad Akhtar, Christoph Bourauel, and Aldo Boccaccini. "Boswellia sacra Extract-Loaded Mesoporous Bioactive Glass Nano Particles: Synthesis and Biological Effects." Pharmaceutics 14, no. 1 (January 5, 2022): 126. http://dx.doi.org/10.3390/pharmaceutics14010126.

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Bioactive glasses (BGs) are being increasingly considered for numerous biomedical applications. The loading of natural compounds onto BGs to increase the BG biological activity is receiving increasing attention. However, achieving efficient loading of phytotherapeutic compounds onto the surface of bioactive glass is challenging. The present work aimed to prepare novel amino-functionalized mesoporous bioactive glass nanoparticles (MBGNs) loaded with the phytotherapeutic agent Boswellia sacra extract. The prepared amino-functionalized MBGNs showed suitable loading capacity and releasing time. MBGNs (nominal composition: 58 wt% SiO2, 37 wt% CaO, 5 wt% P2O5) were prepared by sol-gel-modified co-precipitation method and were successfully surface-modified by using 3-aminopropyltriethoxysilane (APTES). In order to evaluate MBGNs loaded with Boswellia sacra, morphological analysis, biological studies, physico-chemical and release studies were performed. The successful functionalization and loading of the natural compound were confirmed with FTIR, zeta-potential measurements and UV-Vis spectroscopy, respectively. Structural and morphological evaluation of MBGNs was done by XRD, SEM and BET analyses, whereas the chemical analysis of the plant extract was done using GC/MS technique. The functionalized MBGNs showed high loading capacity as compared to non-functionalized MBGNs. The release studies revealed that Boswellia sacra molecules were released via controlled diffusion and led to antibacterial effects against S. aureus (Gram-positive) bacteria. Results of cell culture studies using human osteoblastic-like cells (MG-63) indicated better cell viability of the Boswellia sacra-loaded MBGNs as compared to the unloaded MBGNs. Therefore, the strategy of combining the properties of MBGNs with the therapeutic effects of Boswellia sacra represents a novel, convenient step towards the development of phytotherapeutic-loaded antibacterial, inorganic materials to improve tissue healing and regeneration.

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37

Körner, Philipp, Jana A. Schleich, Daniel B. Wiedemeier, Thomas Attin, and Florian J. Wegehaupt. "Effects of Additional Use of Bioactive Glasses or a Hydroxyapatite Toothpaste on Remineralization of Artificial Lesions in vitro." Caries Research 54, no. 4 (2020): 336–42. http://dx.doi.org/10.1159/000510180.

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<b><i>Objectives:</i></b> This in vitro study aimed to evaluate and compare the effect of two different bioactive glasses, a hydroxyapatite-containing, fluoride-free toothpaste (HTP) and a fluoride toothpaste (FTP) on the remineralization behavior of initial caries lesions. <b><i>Materials and Methods:</i></b> A total of 100 bovine enamel samples were randomly allocated to five groups of 20 samples each: NC = negative control group (artificial saliva); HTP = HTP group (Karex); FTP = FTP group (Elmex caries protection, 1,400 ppm); FTP + BG<sub>nano</sub> = FTP followed by Actimins bioactive glass; FTP + BG<sub>amorph</sub> = FTP followed by Schott bioactive glass. Radiographic documentation (advanced transversal microradiography; aTMR) was applied before and after all samples were exposed to a demineralizing gel for 10 days. Over a period of 28 days, samples were covered twice a day (every 12 h) with a toothpaste slurry of the respective test group or with artificial saliva in NC for 60 s and brushed with 15 brushing strokes. Samples in FTP + BG<sub>nano</sub> and FTP + BG<sub>amorph</sub> were additionally treated with the respective bioactive glass slurry for 30 s after brushing with the FTP. In the meantime, all samples were stored in artificial saliva. After 28 days, the structure of all samples was assessed again using aTMR and compared to the values measured after demineralization. The statistical evaluation of the integrated mineral loss was performed using Kruskal-Wallis test followed by a post hoc Conover test. <b><i>Results:</i></b> The FTP revealed the significantly highest increase of mineral content while the HTP showed the significantly lowest remineralization. Compared to artificial saliva, the use of the HTP or the combined application of FTP followed by bioactive glasses (FTP + BG<sub>nano</sub> and FTP + BG<sub>amorph</sub>) showed no significant remineralization. <b><i>Conclusion:</i></b> Under remineralizing in vitro conditions, brushing with 1,400 ppm FTP induced significantly more remineralization compared to storage in artificial saliva. The additional administration of both bioactive glasses as well as the substitutional brushing with an HTP resulted in significantly less remineralization compared to brushing with 1,400 ppm FTP.

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38

Contreras Jaimes, Altair T., Araceli de Pablos-Martín, Katrin Hurle, Juliana Martins de Souza e Silva, Lutz Berthold, Thomas Kittel, Aldo R. Boccaccini, and Delia S. Brauer. "Deepening our understanding of bioactive glass crystallization using TEM and 3D nano-CT." Journal of the European Ceramic Society 41, no. 9 (August 2021): 4958–69. http://dx.doi.org/10.1016/j.jeurceramsoc.2021.02.051.

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39

LIU, Yongxing, Kanji TSURU, Satoshi HAYAKAWA, and Akiyoshi OSAKA. "In Vitro Bioactive Nano-Crystalline TiO2 Layers Grown at Glass-Coating/Titanium Interface." Journal of the Ceramic Society of Japan 112, no. 1308 (2004): 452–57. http://dx.doi.org/10.2109/jcersj.112.452.

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40

Li, Peiyi, Yanfei Li, Tszyung Kwok, Tao Yang, Cong Liu, Weichang Li, and Xinchun Zhang. "A bi-layered membrane with micro-nano bioactive glass for guided bone regeneration." Colloids and Surfaces B: Biointerfaces 205 (September 2021): 111886. http://dx.doi.org/10.1016/j.colsurfb.2021.111886.

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41

Ratha, Itishree, Akrity Anand, Sabyasachi Chatterjee, Biswanath Kundu, and Gopinatha Suresh Kumar. "Preliminary study on effect of nano-hydroxyapatite and mesoporous bioactive glass on DNA." Journal of Materials Research 33, no. 11 (June 12, 2018): 1592–601. http://dx.doi.org/10.1557/jmr.2018.114.

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42

Zhou, Zhihua, Baoli Ou, Tianlong Huang, Wennan Zeng, Lihua Liu, Qingquan Liu, Jian Chen, et al. "BiocompatibilityIn-vitroof Gel/HA Composite Scaffolds Containing Nano-Bioactive Glass for Tissue Engineering." Journal of Macromolecular Science, Part A 50, no. 10 (January 2013): 1048–53. http://dx.doi.org/10.1080/10601325.2013.821903.

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43

Ray, Sambit, and Sudip Dasgupta. "First principle study on in-vitro antimicrobial properties of nano 52S4.6 bioactive glass." Ceramics International 46, no. 9 (June 2020): 13886–92. http://dx.doi.org/10.1016/j.ceramint.2020.02.182.

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44

Wang, S., M. M. Falk, A. Rashad, M. M. Saad, A. C. Marques, R. M. Almeida, M. K. Marei, and H. Jain. "Evaluation of 3D nano–macro porous bioactive glass scaffold for hard tissue engineering." Journal of Materials Science: Materials in Medicine 22, no. 5 (March 29, 2011): 1195–203. http://dx.doi.org/10.1007/s10856-011-4297-4.

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45

Mabrouk, M., M. M. Selim, Hanan Beherei, and M. I. El-Gohary. "Effect of incorporation of nano bioactive silica into commercial Glass Ionomer Cement (GIC)." Journal of Genetic Engineering and Biotechnology 10, no. 1 (June 2012): 113–19. http://dx.doi.org/10.1016/j.jgeb.2012.01.001.

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46

AlSubaie, Abdulelah, Zenab Sarfraz, Abdulhadi AlAli, Abdulmohsen AlEssa, Hassan AlSubaie, Asma Shah, and Abdul Khan. "Effect of nano-zinc oxide and fluoride-doped bioactive glass-based dentifrices on esthetic restorations." Dental and Medical Problems 56, no. 1 (March 29, 2019): 59–65. http://dx.doi.org/10.17219/dmp/103597.

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47

Christy, P. Narmatha, S. Khaleel Basha, and V. Sugantha Kumari. "Nano zinc oxide and nano bioactive glass reinforced chitosan/poly(vinyl alcohol) scaffolds for bone tissue engineering application." Materials Today Communications 31 (June 2022): 103429. http://dx.doi.org/10.1016/j.mtcomm.2022.103429.

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48

Demirel, Mehmet Gökberkkaan, and Makbule Tuğba Tunçdemir. "Mechanical properties of resin composites containing bioactive glass and experimental nano zinc-silica complex." International Dental Research 11, Suppl. 1 (September 30, 2021): 137–42. http://dx.doi.org/10.5577/intdentres.2021.vol11.suppl1.21.

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Анотація:

Aim: Secondary caries is an important problem in dental composite restoration, and nanoparticles are commonly added to the structures of resin composites to improve their antimicrobial properties. The aim of this study is to evaluate the mechanical properties of composite materials containing bioactive glass (BAG) and an experimental nano zinc-silica (NZS) complex. Methodology: An experimental resin composite containing 70 wt% filler was produced and used as a control sample. This experimental resin composite was then modified by adding different amounts of BAG (10%), NZS (10%), and both BAG and NZS (10% + 10%). NZS was synthesized in situ by milling zinc and silica to nanoscale level. Compressive strength and flexural strength were investigated using a universal testing machine. Data were analyzed using one-way ANOVA and the Tukey post-hoc test. Results: There were no statistically significant differences in compressive strength caused by the filler amount, but statistically significant changes were found in flexural strength. Although the addition of antimicrobial agents to resin composites reduces their physical properties, this is not a clinically unacceptable limit. Conclusion: NZS exhibits better mechanical properties than does BAG, but both materials can be used safely in restorative materials. How to cite this article: Tunçdemir MT, Demirel MG. Mechanical properties of resin composites containing bioactive glass and experimental nano zinc-silica complex. Int Dent Res 2021;11(Suppl.1):137-42. https://doi.org/10.5577/intdentres.2021.vol11.suppl1.21 Linguistic Revision: The English in this manuscript has been checked by at least two professional editors, both native speakers of English.

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Kinasih, Catur Putri, Didin Erma Indahyani, Izzata Barid, and Niken Probosari. "Analisis Kebocoran Tepi pada Glass Ionomer Kaca dengan Penambahan Bioactive Glass Berbasis Silica dari Ampas Tebu." STOMATOGNATIC - Jurnal Kedokteran Gigi 15, no. 2 (October 9, 2018): 37. http://dx.doi.org/10.19184/stoma.v15i2.17931.

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Анотація:

The use of Glass Ionomer Cement (GIC) has some limitation, such as water sensitivity which leads to formation of microleakage due to shrinkage and brittle. Incorporation of 0.04 wt% bioactive glass nano silica (BAG) with GIC enhances its bioactivity to forming hydroxycarbonate apatite (HCA) leading to preventing of marginal gap formation. The objective this study was To determine the difference of microleakage means value between GIC and GIC which has been added by BAG from bagasse. In this study making BAG from bagasse, than choose the samples (24 bovine) randomly and grouping them to be 4 groups, which are group 1, GIC; group 2, GIC+Vaseline, group 3, GIC+BAG; group 4 GIC+BAG+Vaseline. All of the samples are supposed to be preparation, placed of the restoration, and stored in the aquadest then methylen blue 1% in sequence at 37oC until 24 h. The microleakage means value is decided by scoring system depend on the penetration of methylen blue 1% at occlusal wall and gingival wall. The microleakage means value on GIC+BAG is smaller than GIC, but their differences were not significant.

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Zhu, Xuanru, Aida Kazemi, Yunqing Dong, Qiao Pan, Panshi Jin, Biao Cheng, and Yangog Yang. "Effectiveness of Nano Bioactive Glass Fiber Loaded with Platelet-Rich Plasma on Thermal Wound Healing Process in Rats." Journal of Biomedical Nanotechnology 18, no. 2 (February 1, 2022): 535–45. http://dx.doi.org/10.1166/jbn.2022.3249.

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In this study we evaluated the impact of topical application of bioactive glass fibers loaded PRP on a deep seconddegree thermal wound and its healing process sub-streaming molecular pathway of re-epithelialization. Wistar rats were randomly divided into four groups: normal control group, model group (deep second-degree thermal wound), PRP group, and PRP+nanobioactive glass fiber group. After treatment, the changes of wounds were observed daily. H&E staining was used to evaluate the pathological changes and also, qRT-PCR was used to detect the mRNA expression of KGF, IL-1, IL-6, IL-10, TGF-β, EGF, VEGF, HIF-1α, integrin α3 and integrin β1 in wound tissues. In the current study, we observed that PRP group and the PRP group basically re-epithelized on the 21st day. The wound healing rates of the PRP+nanobioactive glass fiber group and PRP group at each time point were higher than those in the model group, while there was no significant difference in wound healing rate between the PRP+nanobioactive glass fiber group and PRP group at each time point. H&E staining showed that the pathological scores of skin wound repairing in the PRP+nanobioactive glass fiber group on the 7th, 14th and 21st day were higher than that of in the model group. The qPCR results suggested the mRNA expression of IL-1, IL-6 and IL-10 in the PRP+nanobioactive glass fiber group and the PRP group were lower than those in the untreated group on the 14th day; the expression of VEGF and EGF mRNA were higher on the 3rd day; the mRNA expression of TGF-β, HIF-1α showed a tendency of increasing first and decreasing then; integrin β1 mRNA expression increased significantly, which was highest; integrin α3 mRNA expression was higher on day 3rd and 21th, respectively. The PRP+nanobioactive glass fibers and PRP can shorten the wound healing time and improve the healing quality mainly by promoting the wound epithelization through increasing the expression of EGF, VEGF, TGF-β, HIF-1α, Integrin α3, and meanwhile increasing the release of Integrin β1 and other mechanisms.

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