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Статті в журналах з теми "Naïve phage library"
Sloth, Ane Beth, Babak Bakhshinejad, Malte Jensen, Camilla Stavnsbjerg, Mikkel Baldtzer Liisberg, Maria Rossing, and Andreas Kjaer. "Analysis of Compositional Bias in a Commercial Phage Display Peptide Library by Next-Generation Sequencing." Viruses 14, no. 11 (October 29, 2022): 2402. http://dx.doi.org/10.3390/v14112402.
Повний текст джерелаSabir, Jamal S. M., Ahmed Atef, Fotouh M. El-Domyati, Sherif Edris, Nahid Hajrah, Ahmed M. Alzohairy, and Ahmed Bahieldin. "Construction of naïve camelids VHH repertoire in phage display-based library." Comptes Rendus Biologies 337, no. 4 (April 2014): 244–49. http://dx.doi.org/10.1016/j.crvi.2014.02.004.
Повний текст джерелаSommavilla, R., V. Lovato, A. Villa, D. Sgier, and D. Neri. "Design and construction of a naïve mouse antibody phage display library." Journal of Immunological Methods 353, no. 1-2 (February 2010): 31–43. http://dx.doi.org/10.1016/j.jim.2010.01.003.
Повний текст джерелаWagner, Hanna, Sarah Wehrle, Etienne Weiss, Marco Cavallari, and Wilfried Weber. "A Two-Step Approach for the Design and Generation of Nanobodies." International Journal of Molecular Sciences 19, no. 11 (November 2, 2018): 3444. http://dx.doi.org/10.3390/ijms19113444.
Повний текст джерелаKamstrup Sell, Danna, Ane Beth Sloth, Babak Bakhshinejad, and Andreas Kjaer. "A White Plaque, Associated with Genomic Deletion, Derived from M13KE-Based Peptide Library Is Enriched in a Target-Unrelated Manner during Phage Display Biopanning Due to Propagation Advantage." International Journal of Molecular Sciences 23, no. 6 (March 18, 2022): 3308. http://dx.doi.org/10.3390/ijms23063308.
Повний текст джерелаKilleen, G. F., B. D. Foy, R. H. Frohn, D. Impoinvil, A. Williams, and J. C. Beier. "Enrichment of a single clone from a high diversity library of phage-displayed antibodies by panning withAnopheles gambiae(Diptera: Culicidae) midgut homogenate." Bulletin of Entomological Research 93, no. 1 (January 2003): 31–37. http://dx.doi.org/10.1079/ber2002216.
Повний текст джерелаQiu, Yu-Lou, Qing-Hua He, Yang Xu, Arun K. Bhunia, Zhui Tu, Bo Chen, and Yuan-Yuan Liu. "Deoxynivalenol-mimic nanobody isolated from a naïve phage display nanobody library and its application in immunoassay." Analytica Chimica Acta 887 (August 2015): 201–8. http://dx.doi.org/10.1016/j.aca.2015.06.033.
Повний текст джерелаPark, Sae-Gwang, Yong-Joo Jeong, Yong-Yi Lee, Ik-Jung Kim, Su-Kil Seo, Eui-Joong Kim, Heung-Chae Jung, et al. "Hepatitis B virus-neutralizing anti-pre-S1 human antibody fragments from large naïve antibody phage library." Antiviral Research 68, no. 3 (December 2005): 109–15. http://dx.doi.org/10.1016/j.antiviral.2005.06.012.
Повний текст джерелаEnglish, Hejiao, Jessica Hong, and Mitchell Ho. "Ancient species offers contemporary therapeutics: an update on shark VNAR single domain antibody sequences, phage libraries and potential clinical applications." Antibody Therapeutics 3, no. 1 (January 2020): 1–9. http://dx.doi.org/10.1093/abt/tbaa001.
Повний текст джерелаFeng, Mingqian, Hejiao Bian, Xiaolin Wu, Tianyun Fu, Ying Fu, Jessica Hong, Bryan D. Fleming, Martin F. Flajnik, and Mitchell Ho. "Construction and next-generation sequencing analysis of a large phage-displayed VNAR single-domain antibody library from six naïve nurse sharks." Antibody Therapeutics 2, no. 1 (November 7, 2018): 1–11. http://dx.doi.org/10.1093/abt/tby011.
Повний текст джерелаДисертації з теми "Naïve phage library"
Hald, Rikke. "Generation and characterisation of a naive human antibody phage display library : a resource for clinically relevant reagents /." Cph. : Department of Pharmacology, The Danish University of Pharmaceutical Sciences, 2004. http://www.dfh.dk/phd/defences/rikkehald.htm.
Повний текст джерелаHuang, Shih-Tsung, and 黃仕聰. "Development of Fully Human Anti-HDGF Antibody from Phage-Displayed Human Naïve ScFv Library." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/92wr6a.
Повний текст джерела國立中山大學
海洋生物科技博士學位學程
107
Hepatocellular carcinoma (HCC), a deadly disease worldwide. For advanced HCC therapy, Sorafenib is the only conventional drug, however, low response rate, drug resistance, and strong side effects had been reported in Sorafenib therapy. Therefore, investigation of novel therapeutic strategy is a critical issue. HDGF is a cancerous factor in various cancer types including HCC. To develop anti-HDGF neutralizing antibody, phage display technology provides an effective in vitro selection strategy to identify fully human antibody. In the biopanning, thirteen HDGF affinity phage clones had been identified from phage display human naïve scFv library using unique Fc fusion protein/protein G dynabeads method. After fully human IgG construction and production, these antibodies were further confirmed binding affinity using ELISA, immunofluorescence, and HDGF conditional knockdown Huh7 cell line. Among them, hmAb-7 exhibited multiple anti-cancer activity, including cell growth, colony formation, invasion and sphere formation in Huh7, HepG2, and SK-Hep1 cells. The anti-cancer effects of hmAb-7 might participated with downregulation of PI3K/AKT/mTOR signaling pathway. The hmAb-7 inhibits of invasion through MMP-2 down-regulation; sphere formation was eliminated through downregulation of cancer stemness genes. In continuously cultured Huh7 and HepG2 cells, these cells present higher colony and spheroid forming features, however, the cancerous behavior able to abolish through hmAb-7 treatment. In sorafenib resistant Huh7 cells, hmAb-7 presents colony and sphere inhibition ability. Furthermore, the Huh7 xenograft model in NOD/SCID mice was performed and the data indicated that hmAb-7 slightly inhibited tumor growth (p = 0.1091) and prolong the overall survival for 14 days. Although anti-HDGF hmAb-7 single treatments not significantly inhibit tumor growth in vivo, but based on the cancerous inhibition effects in vitro, combination therapy might provide an approach to enhance therapeutic effect. Furthermore, a HDGF sandwich ELISA platform with well linear range between 10-0.15625 ng/ml has been established and able to detect the HDGF level in human and rat serum. Anti-HDGF antibody was also used for extended applications, included in analgesic application and allow to treat cancer stemness and Sorafenib drug resistant Huh7 cells (Huh7-SR). Our finding indicated anti-HDGF hmAb-7 exhibited analgesic effect in rat chronic constrictive injury (CCI) model plus with Adenoviral HDGF gene delivery. Besides, hmAb-7 not only shown sphere and colony inhibitory effects in continuous spheroid cell cultured Huh7 and HepG2 cells, but also inhibited cancerous behaviors in Huh7-SR cells. Finally, adenovirus mediated anti-HDGF-scFv gene delivery suppressed the colony and sphere formation in both Huh7 and Huh7-SR cells. The adenovirus mediated scFv gene delivery provided a novel approach for anti-HDGF therapy and allowed for further basic studies.
Частини книг з теми "Naïve phage library"
Zhu, Zhongyu, and Dimiter S. Dimitrov. "Construction of a Large Naïve Human Phage-Displayed Fab Library Through One-Step Cloning." In Therapeutic Antibodies, 129–42. Totowa, NJ: Humana Press, 2008. http://dx.doi.org/10.1007/978-1-59745-554-1_6.
Повний текст джерелаOmar, Noorsharmimi, and Theam Soon Lim. "Construction of Naive and Immune Human Fab Phage-Display Library." In Methods in Molecular Biology, 25–44. New York, NY: Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4939-7447-4_2.
Повний текст джерелаWang, Xin, and Brian B. Cao. "Screening of Specific Internalization Fab Fragment from Human Naive Phage Library by Combinational Bio-Panning." In Therapeutic Antibodies, 161–74. Totowa, NJ: Humana Press, 2008. http://dx.doi.org/10.1007/978-1-59745-554-1_8.
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