Дисертації з теми "NADPH oxidase (Nox) family"
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Okasha, Mohamed Elsir Elnabeeb. "Identification and quantification of regional expression of members of the NADPH oxidase (NOX) enzyme family during the estrous cycles in the bovine oviduct /." Berlin : Mbv, 2009. http://d-nb.info/994595913/04.
Повний текст джерелаOkasha, Mohamed Elsir Elnageeb [Verfasser]. "Identification and quantification of regional expression of members of the NADPH oxidase (NOX) enzyme family during the estrous cycles in the bovine oviduct / Mohamed Elsir Elnageeb Okasha." Berlin : Freie Universität Berlin, 2009. http://d-nb.info/1023582287/34.
Повний текст джерелаCavallin, Lucas E. "The Role of PDGF AND Rac1-induced Oxidative Signaling in the Viral Oncogenesis of Kaposi's Sarcoma." Scholarly Repository, 2010. http://scholarlyrepository.miami.edu/oa_dissertations/441.
Повний текст джерелаChen, Alpha Yan. "Role of Intracellular Oxidant Release in Oxidised Low Lipoprotein - Induced U937 Cell Death." Thesis, University of Canterbury. School of Biological Science, 2012. http://hdl.handle.net/10092/7006.
Повний текст джерелаBednorz, Mariola [Verfasser]. "Die Rolle der NADPH-Oxidase (NOX)-Untereinheit, Nox Organizer 1 (NOXO1), in der Pathogenese des Zigarettenrauch-induzierten Lungenemphysem und der pulmonalen Hypertonie im Mausmodell / Mariola Bednorz." Gießen : Universitätsbibliothek, 2021. http://d-nb.info/1225774217/34.
Повний текст джерелаLambeth, Elise. "Characterisation of a family of NADPH oxidase encoding genes in the roice blast Magnaporthe oryzae." Thesis, University of Exeter, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.529318.
Повний текст джерелаKarimi, Gilda. "Etude de l'assemblage de la NADPH oxydase du phagocyte." Thesis, Paris 11, 2014. http://www.theses.fr/2014PA112025.
Повний текст джерелаThe NADPH oxidase of phagocytes is an enzyme involved in the innate defense of organisms against pathogens. After phagocyte activation, this enzyme produces superoxide ions by reduction of dioxygen by NADPH. It is constituted of four cytosolic sub-units (p47phox ; p67phox ; p40phox et Rac) and two membrane proteins (gp91 ; p22phox). Its activation takes place through a complex process that involves protein-protein interaction changes leading to assembly and functionning of the catalytic core. In order to obtain information on this process, I have reconstituted the enzyme in a cell free systeme using recombinant proteins, to be able to fully control all the measurement conditions. In this work, we have compared different activation modes of p47phox i) phosphorylation; ii) substitution serine - aspartate by mutations at positions S303, S304 and S328 to mimic phosphorylation; iii) addition of arachidonic acid (AA), a well known activator molecule in vitro. It has been shown that these three activating methods transform p47phox to an open configuration with similar characteristics. However, we have found that the effects of these methods are significantly different. Indeed, the conformational changes observed by circular dichroism are different. For p47phox, the addition of AA destructures the protein. Its phosphorylation induces a bathochromic displacement of the bands, whereas the mutations S-D lead to an opposite displacement. For the dimer p47phox-p67phox , the addition of AA destructures the proteins while mutations induce hardly no changes. We have measured the dissociation constant Kd of the complex p47phox-p67phox. For wild type proteins, Kd value is low (4±2 nM), while mutations of p47phox as well as addition of AA increase its value up to 50 nM, showing a decrease of affinity between p47phox and p67phox. Moreover, on the whole complex, the effect of phosphorylation of p47phox is different from mutations. We have shown that the EC50 values relative to p67phox are sensitive to the various modifications of p47phox. Phosphorylation of p47phox decreases EC₅₀, while double or triple mutations increase its value. We have confirmed that phosphorylation and mutation are not sufficient to activate the enzyme. The presence of AA is a prerequisite for the functionning of the complex, i.e. production of superoxide. The binding order of the cytosolic proteins seems random but it is necessary that all the components be present during the activation by AA. Finally, deletion of the C terminal part of p47phox (aa 343 to 390, interaction domain with p67phox) leads to the absence of dimer formation but does not affect the enzyme activity. These results bring new information on the role of dimerisation of p47-p67 and on that of phosphorylation in the activation of NADPH oxidase in vitro
Debbabi, Maya. "Mécanismes de régulation de la NADPH Oxydase NOX1 : rôle de la phosphorylation de NOXA1 ( NOX Activator 1 ) et de NOXO1 ( NOX Organizer 1)." Phd thesis, Université Paris Sud - Paris XI, 2011. http://tel.archives-ouvertes.fr/tel-00769943.
Повний текст джерелаFan, Lampson Min. "The role of endothelial cells in the regulation of the vascular response to Angiotensin II." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:3723698f-11e4-456f-9988-4020ec94ae87.
Повний текст джерелаHernandez, Isabelle. "Étude de l’expression, de l’activité et du rôle de la NADPH oxydase dans la villosité choriale au premier trimestre de la grossesse : implication dans la physiopathologie de la prééclampsie NADPH oxidase is the major source of placental superoxide in early pregnancy: association with MAPK pathway activation sFlt-1 secretion in early first trimester chorionic villi is associated with p38 MAPK pathway activation NADPH oxydase : enzyme potentiellement impliquée dans la physiopathologie de la prééclampsie." Thesis, Sorbonne Paris Cité, 2019. http://www.theses.fr/2019USPCB051.
Повний текст джерелаThe placenta is a transitory organ allowing gas and nutrients exchanges between mother and fetus. The structural and functional unit of the human placenta is the chorionic villi (CV). It is composed by a mesenchymal axis covered with a cellular layer called villous cytotrophoblast (VCT), which merges to form the syncytiotrophoblast (ST). The ST secretes hormones essential to maintain pregnancy, especially hCG. During the first trimester of pregnancy (T1), placenta develops itself in a poor oxygenated environment because of the obstruction of uterine spiraled arteries by cytotrophoblastic plugs which restrain the entry of the oxygenated maternal blood into the intervillous space (IVS). Between 10-12 gestational weeks (GW), the plugs will gradually disappear allowing blood to enter IVS in direct contact with CV. The pO2 will increase from 20 mmHg to 60 mmHg. Exposed to O2, the cell produces reactive oxygen species (ROS). ROS play a role as second messenger in redox-sensitive signaling pathways involved in physiological processes (proliferation, differentiation, apoptosis). They may become cytotoxic when oxidative stress occurs: the cell has an antioxidant defense system responsible for keeping low physiological levels of intracellular ROS, enough to ensure signal transduction. The balance between pro- and antioxidant systems is called redox homeostasis. The first trimester placenta is submitted to an environmental transition requiring redox balance adaptation to allow correct placental development in early pregnancy. The aim of this works are: (i) to determine the principal source of superoxide anion O2.- before and after the increase of pO2 in the intervillous space and the associated antioxidant defenses. (ii) To study the impact of the O2 transition on the activity of redox-sensitive pathways, specifically MAPKs involved in trophoblastic proliferation, differentiation. (iii) To determine, during T1, the placental NADPH oxidase (Nox) activity influence on the secretion of the antiangiogenic factor sFlt-1, which is involved in the pathophysiology of preeclampsia (PE), to offer new insight about Nox involvement in genesis of this pathology with placental origin. We measured the O2.- production in CV (7-9 GW vs. 12-14 GW). The O2.- assay was performed with specific inhibitors of ROS sources. The results show that NADPH oxidase (Nox) is the major source of O2.- in first trimester CV. Nox activity is significantly higher before 10 GW. This is confirmed by the modification of the Nox2 organizer subunit location, p47phox. This Nox activation in early stage of pregnancy is associated with p38 MAPK activation. p38 protein is mainly located within the villous cytotrophoblast in first trimester CV. Genic and protein expression study reveals the expression of Nox2, Nox4 and Nox5 isoforms in T1 trophoblast. Nox1 expression remains undetectable. The antioxidant enzymes (SOD1, catalase, and Gpx1) activities are increased at 12-14 GW, revealing an antioxidant system adaptation to the oxygen transition. We exposed CV from 7 to 9 GW to TGF-B1, described as an activator of Nox4 and p38MAPK, and to p38 inhibitor (SB203580). The results showed that the activation of p38MAPK pathway in first trimester CV by TGF-B1 increases the level of secreted sFlt-1. This effect is abolished using SB203580. TGF-B1 exposure does not influence the activation of placental Nox in our model, but the use of a Nox inhibitor (DPI) decreases the secretion of sFlt-1. To conclude, our work shows that Nox is the main source of O2.- in first trimester placenta and is associated with the activation of the p38MAPK pathway. Our results also demonstrate that first trimester CV sFlt-1 secretion relies on the p38MAPK activation. This work allows a better understanding of the cellular sources of ROS involvement in early placental development and their role in pathogenesis of preeclampsia
Azizian, Azadeh. "Angiotensin II induziert Nox 2 -abhängig Arrhythmien in ventrikulären Kardiomyozyten der Maus." Doctoral thesis, 2015. http://hdl.handle.net/11858/00-1735-0000-0023-965F-2.
Повний текст джерелаGoetze, Robert Günther. "Biomarker für Oxidativen Stress bei Entzündungsreaktionen: Bedeutung von Genpolymorphismen und Genexpression der NADPH-Oxidase unter pro- und anti-inflammatorischen Bedingungen." Doctoral thesis, 2013. http://hdl.handle.net/11858/00-1735-0000-0001-BBF0-5.
Повний текст джерелаWhitehouse, Scott David. "THE EFFECTS OF P22PHOX GENETIC POLYMORPHISMS AND NATURAL COMPOUNDS ON REACTIVE OXYGEN SPECIES FORMATION." 2013. http://hdl.handle.net/10222/21436.
Повний текст джерелаTzu-YiChan and 詹子頤. "The role of leukocyte NADPH oxidase in the regulation of IL-1 family cytokines and innate lymphoid cells in serum-induced arthritis." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/72eqcm.
Повний текст джерелаBarata, Joana Ribeiro. "The role of PKCd [delta] as a regulator of the Nox1 contribution for the mechanism of paraquat induced dopaminergic neurotoxicity." Master's thesis, 2010. http://hdl.handle.net/10400.6/3938.
Повний текст джерелаMorais, Ana Francisca da Silva. "Antioxidant enzymes and their role in paraquat induced dopaminergic toxicity." Master's thesis, 2010. http://hdl.handle.net/10400.6/3937.
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