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Статті в журналах з теми "N-methylhydantoin"

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Автор: Grafiati

Опубліковано: 6 вересня 2023

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1

Kim, Jong Min, Sakayu Shimizu, and Hideaki Yamada. "Amidohydrolysis of N-methylhydantoin coupled with ATP hydrolysis." Biochemical and Biophysical Research Communications 142, no. 3 (February 1987): 1006–12. http://dx.doi.org/10.1016/0006-291x(87)91514-2.

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2

Ogawa, Jun, Warawadee Nirdnoy, Hideaki Yamada, and Sakayu Shimizu. "Nucleoside-Triphosphatase Activity of an ATP-Dependent Enzyme,N-Methylhydantoin Amidohydrolase." Bioscience, Biotechnology, and Biochemistry 59, no. 9 (January 1995): 1737–39. http://dx.doi.org/10.1271/bbb.59.1737.

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3

Hermann, Monika, Hans-Jürgen Knerr, Norbert Mai, Andreas Groß, and Heinrich Kaltwasser. "Creatinine and N-methylhydantoin degradation in two newly isolated Clostridium species." Archives of Microbiology 157, no. 5 (May 1992): 395–401. http://dx.doi.org/10.1007/bf00249094.

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4

Kim, Jorg Min, Sakayu Shimizu, and Hideaki Yamada. "Cytosine deaminase that hydrolyzes creatinine to N-methylhydantoin in various cytosine deaminase-forming microorganisms." Archives of Microbiology 147, no. 1 (1987): 58–63. http://dx.doi.org/10.1007/bf00492905.

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5

Ogawa, Jun, Jong Min Kim, Warawadee Nirdnoy, Yasushi Amano, Hideaki Yamada, and Sakayu Shimizu. "Purification and Characterization of an ATP-dependent Amidohydrolase, N-methylhydantoin Amidohydrolase, from Pseudomonas putida 77." European Journal of Biochemistry 229, no. 1 (April 1995): 284–90. http://dx.doi.org/10.1111/j.1432-1033.1995.0284l.x.

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6

Ran, Yuan, Yu Zhang, Xin Wang, and Guohong Li. "Nematicidal Metabolites from the Actinomycete Micromonospora sp. WH06." Microorganisms 10, no. 11 (November 16, 2022): 2274. http://dx.doi.org/10.3390/microorganisms10112274.

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A nematicidal actinomycete strain WH06 was isolated from soil samples and was identified using 16S rRNA as Micromonospora sp. Through medium screening and fermentation, 10 metabolites were isolated from the ethyl acetate extract of its fermentation broth using Sephadex LH-20 and silica gel column chromatography. These compounds were identified as N-acetyltyramine (1), N-acetyltryptamine (2), 1-methylhydantoin (3), benzenepropanoic acid (4), cyclo-(L-Pro-L-Tyr) (5), cyclo(L-Phe-Gly) (6), catechol (7), methyl (4-hydroxyphenyl)acetate (8), 3-hydroxybenzoic acid (9), and 4-hydroxybenzoic acid (10). In an in vitro assay against Meloidogyne incognita, a root-knot nematode, compounds 1, 4, 9, and 10 show nematicidal activity. Among them, benzenepropanoic acid (4) causes 99.02% mortality of nematode at 200 μg mL−1 after 72 h. Moreover, compound 4 also displays activity in inhibiting egg hatching of M. incognita. This suggests that Micromonospora sp. WH06 is a promising candidate for biocontrol of M. incognita.

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7

Ogawa, Jun, Warawadee Nirdnoy, Masayoshi Tabata, Hideaki Yamada, and Sakayu Shimizu. "A New Enzymatic Method for the Measurement of Creatinine Involving a Novel ATP-dependent Enzyme,N-Methylhydantoin Amidohydrolase." Bioscience, Biotechnology, and Biochemistry 59, no. 12 (January 1995): 2292–94. http://dx.doi.org/10.1271/bbb.59.2292.

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8

Stasyuk, Nataliya, Andriy Zakalskiy, Wojciech Nogala, Sylwester Gawinkowski, Tomasz Ratajczyk, Magdalena Bonarowska, Olha Demkiv, Oksana Zakalska, and Mykhailo Gonchar. "A reagentless amperometric biosensor for creatinine assay based on recombinant creatinine deiminase and N-methylhydantoin-sensitive CoCu nanocomposite." Sensors and Actuators B: Chemical 393 (October 2023): 134276. http://dx.doi.org/10.1016/j.snb.2023.134276.

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9

Lee, Sujin, Ja Yoon Ku, Byeong Jin Kang, Kyung Hwan Kim, Hong Koo Ha, and Suhkmann Kim. "A Unique Urinary Metabolic Feature for the Determination of Bladder Cancer, Prostate Cancer, and Renal Cell Carcinoma." Metabolites 11, no. 9 (September 2, 2021): 591. http://dx.doi.org/10.3390/metabo11090591.

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Prostate cancer (PCa), bladder cancer (BCa), and renal cell carcinoma (RCC) are the most prevalent cancer among urological cancers. However, there are no cancer-specific symptoms that can differentiate them as well as early clinical signs of urological malignancy. Furthermore, many metabolic studies have been conducted to discover their biomarkers, but the metabolic profiling study to discriminate between these cancers have not yet been described. Therefore, in this study, we aimed to investigate the urinary metabolic differences in male patients with PCa (n = 24), BCa (n = 29), and RCC (n = 12) to find the prominent combination of metabolites between cancers. Based on 1H NMR analysis, orthogonal partial least-squares discriminant analysis was applied to find distinct metabolites among cancers. Moreover, the ranked analysis of covariance by adjusting a potential confounding as age revealed that 4-hydroxybenzoate, N-methylhydantoin, creatinine, glutamine, and acetate had significantly different metabolite levels among groups. The receiver operating characteristic analysis created by prominent five metabolites showed the great discriminatory accuracy with AUC > 0.7 for BCa vs. RCC, PCa vs. BCa, and RCC vs. PCa. This preliminary study compares the metabolic profiles of BCa, PCa, and RCC, and reinforces the exploratory role of metabolomics in the investigation of human urine.

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10

Fossati, P., M. Ponti, G. Passoni, G. Tarenghi, G. V. Melzi d'Eril, and L. Prencipe. "A step forward in enzymatic measurement of creatinine." Clinical Chemistry 40, no. 1 (January 1, 1994): 130–37. http://dx.doi.org/10.1093/clinchem/40.1.130.

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Abstract We describe an improved enzymatic ultraviolet absorbance method for assaying creatinine in serum, plasma, and urine. Creatinine is hydrolyzed by creatinine iminohydrolase (EC 3.5.4.21) to ammonia and N-methylhydantoin. The ammonia produced combines with 2-oxoglutarate and NADPH in the presence of glutamate dehydrogenase to yield glutamate and NADP+. The consumption of NADPH, measured by a two-point fixed-time assay, is proportional to the amount of creatinine in the sample. The assay is carried out in two steps: The first step eliminates background absorbance in hyperlipemic samples and endogenous ammonia through a "clearing system" and an isocitrate dehydrogenase-based "ammonia scavenger system"; the second step starts creatinine measurement. The method affords a simple, rapid, and sensitive assay with good precision and extended linearity; it employs working solutions stable at least 4 months. Test results compare closely with those of the isotope dilution-mass spectrometry Definitive Method, the HPLC procedure, and the fuller's earth method. The proposed method is not subject to interference from several metabolites or from the 72 drugs tested. Because it is easily automated, the method is suitable for routine work in clinical laboratories.

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11

Gasparutto, Didier, Evelyne Muller, Serge Boiteux, and Jean Cadet. "Excision of the oxidatively formed 5-hydroxyhydantoin and 5-hydroxy-5-methylhydantoin pyrimidine lesions by Escherichia coli and Saccharomyces cerevisiae DNA N-glycosylases." Biochimica et Biophysica Acta (BBA) - General Subjects 1790, no. 1 (January 2009): 16–24. http://dx.doi.org/10.1016/j.bbagen.2008.10.001.

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12

Bletsa, Evdoxia, Sebastien Filippas-Dekouan, Christina Kostara, Panagiotis Dafopoulos, Aikaterini Dimou, Eleni Pappa, Styliani Chasapi, et al. "Effect of Dapagliflozin on Urine Metabolome in Patients with Type 2 Diabetes." Journal of Clinical Endocrinology & Metabolism 106, no. 5 (February 16, 2021): 1269–83. http://dx.doi.org/10.1210/clinem/dgab086.

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Abstract Context Inhibitors of sodium-glucose cotransporters-2 have cardio- and renoprotective properties. However, the underlying mechanisms remain indeterminate. Objective To evaluate the effect of dapagliflozin on renal metabolism assessed by urine metabolome analysis in patients with type 2 diabetes. Design Prospective cohort study. Setting Outpatient diabetes clinic of a tertiary academic center. Patients Eighty patients with hemoglobin A1c > 7% on metformin monotherapy were prospectively enrolled. Intervention Fifty patients were treated with dapagliflozin for 3 months. To exclude that the changes observed in urine metabolome were merely the result of the improvement in glycemia, 30 patients treated with insulin degludec were used for comparison. Main Outcome Measure Changes in urine metabolic profile before and after the administration of dapagliflozin and insulin degludec were assessed by proton-nuclear magnetic resonance spectroscopy. Results In multivariate analysis urine metabolome was significantly altered by dapagliflozin (R2X = 0.819, R2Y = 0.627, Q2Y = 0.362, and coefficient of variation analysis of variance, P < 0.001) but not insulin. After dapagliflozin, the urine concentrations of ketone bodies, lactate, branched chain amino acids (P < 0.001), betaine, myo-inositol (P < 0001), and N-methylhydantoin (P < 0.005) were significantly increased. Additionally, the urine levels of alanine, creatine, sarcosine, and citrate were also increased (P < 0001, P <0.0001, and P <0.0005, respectively) whereas anserine decreased (P < 0005). Conclusions Dapagliflozin significantly affects urine metabolome in patients with type 2 diabetes in a glucose lowering-independent way. Most of the observed changes can be considered beneficial and may contribute to the renoprotective properties of dapagliflozin.

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13

Heitger, Andreas, Birgit Juergens, Ursula Hainz, and Dietmar Fuchs. "Potential Tolerizing Capacity of Human Dendritic Cells Featuring High Levels of Expression and Activity of the Tryptophan Metabolizing Enzyme Indoleamine 2,3 Dioxygenase." Blood 108, no. 11 (November 16, 2006): 623. http://dx.doi.org/10.1182/blood.v108.11.623.623.

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Abstract An enhanced tryptophan metabolism mediated by the enzymatic activity of indoleamine 2,3 dioxygenase (IDO) has recently been demonstrated to profoundly affect T cell responses. By the present study we explored whether human dendritic cells (DCs) displaying high IDO expression and activity, down-regulate allogeneic T cell responses. A comparison of lipopolysaccaride (LPS), interferon-γ (IFN-γ), and CD40L as DC maturation agents showed that most abundant IDO expression and activity in DCs was observed when immature DCs were exposed to a combination of LPS and IFN-γ for 48 hours. This time period of maturation was associated with the development of a mature DC phenotype. In contrast, semi-mature DCs, i.e. DCs matured for 4 hours only, were IDO negative. In co-cultures with allogeneic T cells both types of DCs began to metabolize tryptophan, as determined by decreasing concentrations of tryptophan and increasing concentrations of kynurenines in cell culture supernatants, but mature IDO positive DCs did so at a faster rate (complete consumption of tryptophan within 16 hours of co-culture) than semi-mature DCs. A comparison of the allo-stimulatory capacity of semi-mature IDO negative DCs and mature IDO positive DCs showed that at a high DC/T cell ratio (1:1) IDO positive DCs had a significantly reduced capacity to stimulate allogeneic T cells (median 63% reduction, n=5). The reduction of the allogeneic T cell response induced by IDO positive DCs was reversed upon the addition of the IDO inhibitor methylhydantoin-tryptophan to the co-cultures, suggesting an IDO dependent mechanism. Furthermore, allogeneic T cells exposed to IDO positive DCs had an increased rate of apoptosis in the activated cell fraction and after 8 days of co-culture contained a cell fraction (~30%) displaying a CD4+CD25+highFOXP3+ phenotype. These latter cells, when enriched by fluorescent activated cell sorting (FACS), were able to suppress the proliferative response of naive T cells to anti-CD3 mediated stimulation, which indicates the generation of a regulatory T cell population by IDO positive DCs. Together, these findings suggest that the amount of IDO expression and activity by DCs is one feature to govern the type of response of stimulated T cells. Human DCs can be induced to display high levels of IDO expression and activity and, thereby, acquire the ability to effectivley modulate allogeneic T cell responses towards tolerance by eliminating allo-reactive T cells through apoptosis and augmentation of their regulatory rather than their effector potential. Our current approaches address whether this property can be employed to use DCs for the generation of allo-antigen specific tolerance in the setting of hematopoietic cell transplantation.

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14

Poehlein, Anja, Adrian Bandera, Deborah Horne, Joachim Maier, David Pawlowicz, Verena Siebert, and Rolf Daniel. "First Insights into the Genome of the N -Methylhydantoin-Degrading Clostridium sp. Strain FS41 (DSM 6877)." Genome Announcements 3, no. 2 (April 30, 2015). http://dx.doi.org/10.1128/genomea.00394-15.

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15

Abril-Parreño, Laura, Xavier Druart, Sean Fair, and Anette Krogenaes. "Metabolic signature of cervical mucus in ewe breeds with divergent cervical sperm transport: a focus on metabolites involved in amino acid metabolism." Metabolomics 19, no. 7 (June 20, 2023). http://dx.doi.org/10.1007/s11306-023-02021-x.

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Abstract Introduction Cervical artificial insemination (AI) with frozen-thawed semen in sheep has yielded unacceptably low pregnancy rates. The exception is in Norway where vaginal AI yields non-return rates in excess of 60%, which has been attributed to the ewe breed used. Objectives and methods This study aimed to characterise, for the first time, the ovine follicular phase cervical mucus metabolome, with a focus on the amino acid profile. Cervical mucus was collected from four European ewe breeds with known differences in pregnancy rates following cervical AI with frozen-thawed semen. These were Suffolk (low fertility), Belclare (medium fertility), Norwegian White Sheep (NWS) and Fur (both high fertility). Results A total of 689 metabolites were identified in the cervical mucus of all the four ewe breeds. Of these, 458 metabolites were altered by ewe breed, which had the greatest effect in the dataset (P < 0.05). We detected 194 metabolites involved in the amino acid pathway, of which 133, 56 and 63 were affected by ewe breed, type of cycle and their interaction, respectively (P < 0.05). N-methylhydantoin and N-carbamoylsarcosine (degradation products of creatinine pathway) exhibited the greatest fold change decrease in the Suffolk breed compared to Fur and NWS (P < 0.001). Oxidized metabolites were also decreased in Suffolk compared to high fertility breeds (P < 0.05). In contrast, other metabolites such as 3-indoxyl-sulfate, putrescine, cadaverine were significantly increased in Suffolk at the synchronised cycle. Conclusion The suboptimal amino acid profile in the cervical mucus of the low fertility Suffolk breed may have negative consequences for sperm transport.

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16

Solís-González, Claudia Julieta, Lilianha Domínguez-Malfavón, Martín Vargas-Suárez, Itzel Gaytán, Miguel Ángel Cevallos, Luis Lozano, M. Javier Cruz-Gómez, and Herminia Loza-Tavera. "Novel Metabolic Pathway for N-Methylpyrrolidone Degradation in Alicycliphilus sp. Strain BQ1." Applied and Environmental Microbiology 84, no. 1 (October 13, 2017). http://dx.doi.org/10.1128/aem.02136-17.

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ABSTRACTThe molecular mechanisms underlying the biodegradation ofN-methylpyrrolidone (NMP), a widely used industrial solvent that produces skin irritation in humans and is teratogenic in rats, are unknown.Alicycliphilussp. strain BQ1 degrades NMP. By studying a transposon-tagged mutant unable to degrade NMP, we identified a six-gene cluster (nmpABCDEF) that is transcribed as a polycistronic mRNA and encodes enzymes involved in NMP biodegradation.nmpAand the transposon-affected genenmpBencode anN-methylhydantoin amidohydrolase that transforms NMP to γ-N-methylaminobutyric acid; this is metabolized by an amino acid oxidase (NMPC), either by demethylation to produce γ-aminobutyric acid (GABA) or by deamination to produce succinate semialdehyde (SSA). If GABA is produced, the activity of a GABA aminotransferase (GABA-AT), not encoded in thenmpgene cluster, is needed to generate SSA. SSA is transformed by a succinate semialdehyde dehydrogenase (SSDH) (NMPF) to succinate, which enters the Krebs cycle. The abilities to consume NMP and to utilize it for growth were complemented in the transposon-tagged mutant by use of thenmpABCDgenes. Similarly,Escherichia coliMG1655, which has two SSDHs but is unable to grow in NMP, acquired these abilities after functional complementation with these genes. In wild-type (wt) BQ1 cells growing in NMP, GABA was not detected, but SSA was present at double the amount found in cells growing in Luria-Bertani medium (LB), suggesting that GABA is not an intermediate in this pathway. Moreover,E. coliGABA-AT deletion mutants complemented withnmpABCDgenes retained the ability to grow in NMP, supporting the possibility that γ-N-methylaminobutyric acid is deaminated to SSA instead of being demethylated to GABA.IMPORTANCEN-Methylpyrrolidone is a cyclic amide reported to be biodegradable. However, the metabolic pathway and enzymatic activities for degrading NMP are unknown. By developing molecular biology techniques forAlicycliphilussp. strain BQ1, an environmental bacterium able to grow in NMP, we identified a six-gene cluster encoding enzymatic activities involved in NMP degradation. These findings set the basis for the study of new enzymatic activities and for the development of biotechnological processes with potential applications in bioremediation.

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