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De Paepe, Katja, Lawrence Bonne, Nicos Fotiadis, Naureen Starling, Ian Chau, Marco Gerlinger, Sheela Rao, et al. "Complications and seeding risk after percutaneous liver biopsy in an oncological setting." Journal of Clinical Oncology 36, no. 4_suppl (February 1, 2018): 246. http://dx.doi.org/10.1200/jco.2018.36.4_suppl.246.
Повний текст джерелаАнотація:
246 Background: Percutaneous biopsy of suspected liver metastases is a common practice for diagnostic purposes. Particularly, in the setting of oncological clinical trials, it is a relatively non-invasive method to obtain sufficient tissue for molecular analyses at regular set time points. However, various complications may occur, including seeding of the tumour along the biopsy tract. Only few reports exist on the actual incidence of seeding, on a limited number of tumor types. The aim of this study was to evaluate the technique’s safety and risk of seeding. Methods: All patients with an ultrasound or CT-guided liver biopsy between 2012-2016 were included. Medical records were reviewed retrospectively for post-biopsy complications and all follow-up imaging was re-assessed for the presence of seeding, defined as tumoral deposits in the biopsy needle tract. Results: In total 782 biopsies were performed in 550 patients (282 women, 268 men; mean age of 61 years), 43.9% (343/782) for trials and 56.1% (439/782) for diagnostic/molecular purposes, 93.7% (733/782) were diagnostic, revealing malignancy in 96.9% (710/733). Number of biopsies per patient ranged between 1 (n=387) to 7 (n=1), a co-axial system was used in 70.6% (552/782) and multiple passes in 29.4% (230/782). Complications were reported in 8.8% (69/782), more often pain (4.7%) and hypotension/vasovagal (2.3%). Admission and/or re-intervention were needed for more severe complications as bleeding (1.0%), sepsis/fever (1.1%), pulmonary embolism (0.3%) and pneumothorax (0.4%). Seeding was seen in 1.1% (8/782) of cases (2/44 melanoma, 1/11 GIST, 1/39 cholangiocarcinoma, 1/247 colorectal, 1/14 oesophagus, 1/97 breast, 1/31 prostate). Mean time for seeding was 208 days (range 43-469 d); mean post-biopsy survival time was 495 days in the seeding and 349 days in the non-seeding group. Conclusions: Percutaneous liver biopsy is a highly effective and safe method for tissue collection, with only a minimal risk of seeding.
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Adamčák, Štefan, Michal Marko, Andrea Izáková, and Pavol Bartík. "Curriculum preferences of physical education teachers in primary schools: differences in length of pedagogical practice." Health, sport, rehabilitation 9, no. 3 (September 17, 2023): 40–49. http://dx.doi.org/10.58962/hsr.2023.9.3.40-49.
Повний текст джерелаАнотація:
Purpose. Curriculum preferences of physical education (PE) teachers in primary schools differ, depending on educational policy, local guidelines, and particular needs of students (pupils); therefore, the survey objective was aimed at determining the curriculum preferences of PE teachers in primary schools in terms of differences in length of pedagogical practice.
Material and methods. Curriculum preferences of PE teachers in primary schools (survey instrument) was conducted 6 months (January – June, 2022), through the purposive sampling of size (survey group) of 1 300 (100%) PE teachers in primary schools: (i) Pedagogical practice ≥10 years (n = 518, 39.84%); (ii) Pedagogical practice ˂10 years (n = 782, 60.16%). Descriptive (e.g., percentage frequency, arithmetic mean), inferential (e.g., Pearson's r, chi-square test) statistics were used to evaluate (e.g., analyze, compare) the data.
Results. Significant differences (0.01, 0.05) between the pedagogical practice ≥10 years (n = 518, 39.84%) and ˂10 years (n = 782, 60.16%) of PE teachers (n = 1 300, 100%) were as follows: (i) Curriculum preferences of PE teachers (χ2(3) = 77.75, p = 9.35E-17); (ii) Demanding teaching activity in PE teachers (χ2(4) = 29.34; p = 6.65E-06); (iii) Undemanding teaching activity in PE teachers (χ2(4) = 30.10, p = 4.68E-06). No differences (p˃0.05), between the pedagogical practice ≥10 years (n = 518, 39.84%) and ˂10 years (n = 782, 60.16%) of PE teachers (n = 1 300, 100%), were as follows: (i) Popular teaching activity in PE teachers (χ2(4) = 6.82, p = 0.15); (ii) Unpopular teaching activity in PE teachers (χ2(4) = 8.78, p = 0.06).
Conclusions. Curricular reform in Slovak primary schools allows PE teachers autonomy (partial) in selecting the educational content (course) in terms of meeting the specific needs of students and learning environment, in consultation with board of education (school board) in terms of meeting the particular needs of students and learning environment, recognizing the importance of PE teachers' autonomy and value of tailoring education.
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Cramer, Catie, Kathryn Proudfoot, and Theresa Ollivett. "Automated Feeding Behaviors Associated with Subclinical Respiratory Disease in Preweaned Dairy Calves." Animals 10, no. 6 (June 5, 2020): 988. http://dx.doi.org/10.3390/ani10060988.
Повний текст джерелаАнотація:
Little is known about feeding behaviors in young dairy calves with subclinical respiratory disease (SBRD). The objective of this study was to determine if calves with their first case of SBRD exhibit different feeding behaviors during the 7 d around detection, compared to calves with their first case of clinical BRD (CBRD) or without BRD (NOBRD). Preweaned, group-housed dairy calves (n = 103; 21 ± 6 d of age) underwent twice weekly health exams (lung ultrasound and clinical respiratory score; CRS); health exams were used to classify the BRD status for each calf: SBRD (no clinical signs and lung consolidation ≥ 1cm2; n = 73), CBRD (clinical signs and lung consolidation ≥ 1cm2; n = 18), or NOBRD (never had lung consolidation ≥ 1cm2 or CRS+; n = 12). Feeding behavior data (drinking speed, number of visits, and intake volume) were collected automatically. Calves with SBRD and calves with NOBRD had similar drinking speeds (782 vs. 844 mL/min). Calves with CBRD drank slower than both calves with SBRD (688 vs. 782 mL/min) and NOBRD (688 vs. 844 mL/min). There was no effect of BRD status on any other behavior. Feeding behavior was not an effective means of identifying calves with SBRD.
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Linden, Anthony, Teresa de Haro, and Cristina Nevado. "[1,3-Bis(2,6-diisopropylphenyl)imidazol-2-ylidene]chloridogold(I)." Acta Crystallographica Section C Crystal Structure Communications 68, no. 1 (December 6, 2011): m1—m3. http://dx.doi.org/10.1107/s0108270111051365.
Повний текст джерелаАнотація:
The molecule of the title compound, [AuCl(C27H36N2)], which belongs to a class of potentially catalytically active N-heterocyclic carbene complexes, has crystallographicC2symmetry and approximateC2vsymmetry. The structure is isostructural with the CuIand AgIanalogues. A previous report of the structure of the title compound as its toluene solvate [Fructoset al.(2005).Angew. Chem. Int. Ed.44, 5284–5288] has inaccurate geometry for the complex molecule as a consequence of probable incorrect refinement in the space groupCc, instead ofC2/c[Marsh (2009).Acta Cryst.B65, 782–783]. The Au—C bond length of 1.998 (4) Å in the title compound is more consistent with the mean distance of 1.979 (14) Å found in 52 other reported [AuCl(carbene)] complexes than with the shorter distance of 1.942 (3) Å given for the refinement in the space groupCcfor the toluene solvate and the value of 1.939 Å obtained from the recalculation of that structure inC2/c.
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Alansari, B. M. "Gender differences in anxiety among undergraduates from twenty two countries." European Psychiatry 26, S2 (March 2011): 135. http://dx.doi.org/10.1016/s0924-9338(11)71846-6.
Повний текст джерелаАнотація:
ObjectiveThe aim of the current investigation was to explore gender related differences in anxiety among undergraduates from 22 countries.MethodStandard Arabic Version of the Kuwait University Anxiety scale (comprised of 20 brief statements, answered on a 4-point intensity scale, anchored by 1: Rarely and 4: Always) was administered to Arabic undergraduates, recruited from the following countries: Palestine, Lebanon, Syria, Iraq, Jordan, Saudis Arabia, Kuwait, Qatar, Bahrain, U.A. Emirate, Oman, Yemen, Egypt, Sudan, Tunisia, Libya, Algeria, and Morocco. (n = 608, 271, 879, 842, 948, 780, 782, 435, 154, 393, 342, 833, 1185, 275, 291, 295, 375, & 706. While the English Version was administered to American (n = 273) and Pakistan (n = 462) samples, the Germen version was administered to the Germen subjects (n = 157), Moreover the Spanish version was administered to the Spanish sample (n = 312).ResultsIt was found that females significantly had higher mean anxiety scores than did their male counterparts in 15 countries: Palestine, Lebanon, Iraq, Kuwait, Qatar, Oman, Yemen, Egypt, Tunisia, Libya, Algeria, Morocco, Pakistan, American, & Spain.ConclusionFemale preponderance of anxiety has been a consistent finding. In the present researcher opinion, the anxiety score of any given person is the end product of both biological and psychosocial factors and their interaction. Furthermore, the response styles, especially social desirability and the tendency to hyperbole had an impact on anxiety score.
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Aliaga Tovar, Jaime, Luis Rodríguez de los Ríos, Carlos Ponce Díaz, Augusto Frisancho León, and Jorge Enríquez Vereau. "Escala de desesperanza de Beck (BHS): adaptación y características psicométricas." Revista de Investigación en Psicología 9, no. 1 (March 6, 2014): 69. http://dx.doi.org/10.15381/rinvp.v9i1.4029.
Повний текст джерелаАнотація:
En este artículo presentamos la adaptación y el estudio psicométrico de la confiabilidad y validez de la Escala de Desesperanza de Beck (BHS) en la población de Lima Metropolitana. La traducción se realizó con la técnica back translation. La muestra de estudio fue de 782 sujetos (327 varones y 445 mujeres) con edades entre 13 a 19 años (mediana=19 años); dividida en siete grupos: personas con intento de suicidio (n=26); pacientes con depresión mayor o trastorno bipolar (n=23); hipertensos, asmáticos y tuberculosos (n=68); pacientes esquizofrénicos paranoides y con trastornos afectivos (n=22); pacientes dependientes a la pasta básica de cocaína (n=25); estudiantes del 6to. grado de primaria (n=51); y, amas de casa, estudiantes del quinto de secundaria, universitarios, docentes (n=567; población general). El coeficiente alfa de Crombach es de 0.80 (n=782) y el coeficiente de correlación de Pearson de los puntajes del test-retest con un intervalo de dos semanas es 0.60 (n=100). La correlación de la BHS con los ítems que evalúan la desesperanza de la escala de depresión de Beck (BID) es de 0.46; y la correlación con la BID sin los ítemes de desesperanza es de 0.40. El análisis factorial con la técnica de los componentes principales y rotación varimax encuentra 6 factores que explican el 49.32% de la varianza. También se observa que el sexo no se correlaciona con la BHS, pero sí lo hace la edad (p<0.01). Por último, se halla que los pacientes con depresión mayor o trastorno bipolar se agrupan mayoritariamente en las categorías moderado/severo de desesperanza; y los sujetos del grupo población general; los asmáticos, hipertensos, asmáticos, así como los adictos a la PBC se agrupan mayoritariamente en las categorías Normal-asintomático/leve de desesperanza. Se concluye que la BHS adaptada evalúa un constructo psicológicamente significativo y puede ser usada con propósitos de screning.
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Günak, Mia Maria, Jo Billings, Emily Carratu, Natalie L. Marchant, Graziella Favarato, and Vasiliki Orgeta. "Post-traumatic stress disorder as a risk factor for dementia: systematic review and meta-analysis." British Journal of Psychiatry 217, no. 5 (September 15, 2020): 600–608. http://dx.doi.org/10.1192/bjp.2020.150.
Повний текст джерелаАнотація:
BackgroundPost-traumatic stress disorder (PTSD) has been identified as a potential risk factor for developing dementia. There are currently, however, no meta-analyses quantifying this risk.AimsTo systematically review and quantify the risk of future dementia associated with PTSD across populations. PROSPERO registration number CRD42019130392.MethodWe searched nine electronic databases up to 25 October 2019 for longitudinal studies assessing PTSD and risk of dementia. We used random- and fixed-effects meta-analyses to pool estimates across studies.ResultsPTSD was associated with a significant risk for all-cause dementia: pooled hazard ratio HR = 1.61 (95% CI 1.43–1.81, I2= 85.8%, P < 0.001; n = 1 693 678; 8 studies). Pooled HR was 1.61 (95% CI 1.46–1.78; I2= 80.9%, P < 0.001; n = 905 896; 5 studies) in veterans, and 2.11 (95% CI 1.03–4.33, I2= 91.2%, P < 0.001; n = 787 782; 3 studies) in the general population. The association between PTSD and dementia remained significant after excluding studies with high risk of bias (HR = 1.55, 95% CI 1.39–1.73, I2= 83.9%, P < 0.001; n = 1 684 928; 7 studies). Most studies included were retrospective and there was evidence of high heterogeneity.ConclusionsThis is the first meta-analysis quantifying the association of PTSD and risk of dementia showing that PTSD is a strong and potentially modifiable risk factor for all-cause dementia. Future studies investigating potential causal mechanisms, and the protective value of treating PTSD are needed.
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Yan, Chao, Ziwei Tu, Zixian Zhang, Xi Ouyang, Dou Li, Shiyi Peng, and Jun Zhong. "Institutionally validated nomogram predicting prognosis for older patients with nonmetastatic nasopharyngeal carcinoma." Future Oncology 18, no. 15 (May 2022): 1829–38. http://dx.doi.org/10.2217/fon-2021-1121.
Повний текст джерелаАнотація:
Aim: Older adult patients with nonmetastatic nasopharyngeal carcinoma (NPC) have poor outcomes relative to younger patients. The authors’ group established a nomogram to predict the overall survival of older adults with NPC and inform patient management. Methods: Cases with NPC (n = 782) were enrolled in this study; clinical data in the Surveillance, Epidemiology, and End Results database from 2010 to 2015 served as the training cohort (n = 657), and patients from Jiangxi Cancer Hospital (n = 125) served as the external validation cohort. Results: Training and external validation cohort C-index, receiver operator characteristics curves and calibration curves showed that our nomogram has great predictive ability. Conclusions: Compared with tumor-node-metastasis staging, this nomogram can help clinicians better predict the prognosis of older adults with nonmetastatic NPC.
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Gilmore, Daniel A., Donald Gurka, and M. Bonner Denton. "Quantitative Detection of Environmentally Important Dyes Using Diode Laser/Fiber-Optic Raman Spectroscopy." Applied Spectroscopy 49, no. 4 (April 1995): 508–12. http://dx.doi.org/10.1366/0003702953964390.
Повний текст джерелаАнотація:
A compact diode laser/fiber-optic Raman spectrometer is used for quantitative detection of environmentally important dyes. This system is based on diode laser excitation at 782 nm, fiber-optic probe technology, an imaging spectrometer, and a state-of-the-art scientific CCD camera. The dyes studied include trypan blue, acid black 1, acid blue 40, and basic blue 7. Detection sensitivities (at rms S/N = 2) ranged from 0.2 ppm (3.24 × 10−7 M) for acid black 1, to 25 ppm (4.86 × 10−5 M) for basic blue 7.
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Sarma, Amitabha, Sunil M. Patel, Laurie Sturdevant, Mee-chung Puscilla Ip, Carol L. Hundley, Leslie Kian, William Simeone, and Michael Fisch. "Staging documentation accuracy and adherence to workup and treatment guidelines: The M. D. Anderson Regional Care Center experience." Journal of Clinical Oncology 30, no. 34_suppl (December 1, 2012): 244. http://dx.doi.org/10.1200/jco.2012.30.34_suppl.244.
Повний текст джерелаАнотація:
244 Background: MD Anderson Cancer (MDACC) disease-specific faculty experts have developed institutional guidelines for diagnostic workup and treatment of common tumor types. The institution has four Regional Care Centers in suburban Houston staffed by a total of 10general medical oncologists. The primary intent of this project was to measure the accuracy of staging documentation and adherence to guidelines. The secondary intent was to improve documentation and guideline adherence by regularly reporting results directly to the involved physicians. Methods: Between July 2009 and April 2012, charts for all new medical oncology visits for patients with breast, non-small cell lung, or colon cancer for whom no previous medical oncology plan had been implemented were reviewed by a team of quality nurses on a weekly basis. Source documents were analyzed for (a) adherence to MDACC diagnostic workup guidelines (n=782); (b) accuracy of both TNM and AJCC staging documentation (n=782); and (c) adherence to MDACC treatment guidelines (n=731). On a monthly basis, a graph with rates over time of guideline adherence and accuracy of staging documentation was provided to each general oncologist. Results: The adherence rate to MDACC diagnostic workup guidelines was 79%. The agreement rate for accurate documentation of both TNM and AJCC stage was 72%. The adherence rate to MDACC treatment guidelines was 94%. Providing monthly reports of individual results to each physician did not lead to an increase in the rates of adherence of accurate staging documentation. Analysis comparing all Regional Care Center medical oncologists (not provided to the involved physicians) showed significant variation in rates for all three categories. Conclusions: Providing MDACC Regional Care Center general medical oncologists with simple graphs over time reflecting guideline adherence and accuracy of documentation did not lead to any improvement on those measures. More creative interventions to improve performance in these realms will need to be explored.
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Karra, Mahesh, and Kexin Zhang. "User-Centered Counseling and Male Involvement in Contraceptive Decision Making: Protocol for a Randomized Controlled Trial." JMIR Research Protocols 10, no. 4 (April 5, 2021): e24884. http://dx.doi.org/10.2196/24884.
Повний текст джерелаАнотація:
Background To achieve informed choice within the framework of reproductive autonomy, family planning programs have begun to adopt user-centered approaches to service provision, which highlight the individual client as the focal point of interaction and key decision maker. However, little is known about how user-centered approaches to family planning, particularly family planning counseling, shape contraceptive preferences and choices. Objective We conducted a multiarmed randomized controlled trial to identify the causal impact of user-centered approaches to family planning counseling on women’s contraceptive decision making in urban Malawi. This study aims to determine how a tailored, preference-driven approach to family planning counseling and the involvement of male partners during the counseling process may contribute to shaping women’s contraceptive preferences and choices. Methods Married women aged 18-35 years were recruited and randomly assigned to 1 of the 3 intervention arms or a control arm characterized by the following two interventions: an intervention arm in which women were encouraged to invite their husbands to family planning counseling (husband invitation arm) and an intervention arm in which women received targeted, tailored counseling on up to five contraceptive methods (as opposed to up to 13 contraceptive methods) that reflected women’s stated preferences for contraceptive methods. Women were randomized into a control arm, T0 (no husband invitation, standard counseling); T1 (husband invitation, standard counseling); T2 (no husband invitation, targeted counseling); and T3 (husband invitation, targeted counseling). Following counseling, all women received a package of family planning services, which included free transportation to a local family planning clinic and financial reimbursement for family planning services. Follow-up surveys were conducted with women 1 month after counseling. Results A total of 785 women completed the baseline survey, and 782 eligible respondents were randomized to 1 of the 3 intervention groups or the control group (T1, n=223; T2, n=225; T3, n=228; T0, n=108). Furthermore, 98.1% (767/782) of women were contacted for follow-up. Among the 767 women who were contacted, 95.3% (731/767) completed the follow-up survey. The analysis of the primary outcomes is ongoing and is expected to be completed by the end of 2021. Conclusions The results from this trial will fill knowledge gaps on the effectiveness of tailored family planning counseling and male involvement in family planning on women’s stated and realized contraceptive preferences. More generally, the study will provide evidence on how user-centered counseling may affect women’s willingness to use and continue contraception to realize their contraceptive preferences. Trial Registration American Economics Association’s Registry for Randomized Controlled Trials AEARCTR-0004194; https://www.socialscienceregistry.org/trials/4194/history/46808. Registry for International Development Impact Evaluations RIDIE-STUDY-ID-5ce4f42bbc2bf; https://ridie.3ieimpact.org/index.php?r=search/detailView&id=823. International Registered Report Identifier (IRRID) DERR1-10.2196/24884
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Odongo, Mahacla, Lilly Bebora, James Gathumbi, Gabriel Aboge, Lillian Waiboci, and Joseph Erume. "Seroprevalence and spatial distribution of livestock brucellosis using three serological tests in Kajiado County, Kenya." Open Veterinary Journal 13, no. 12 (2023): 1583. http://dx.doi.org/10.5455/ovj.2023.v13.i12.8.
Повний текст джерелаАнотація:
Background: Brucellosis is a serious zoonotic infection with a global socioeconomic impact on both the livestock industry and human health. In Kenya brucellosis is endemic but there is limited information on the true burden of the disease due to weak or peace-meal surveillance. The true burden and spread of animal brucellosis in Kajiado County is not known. Aim: The aim of the study was to determine the current seroprevalence and spatial distribution of livestock brucellosis in Kajiado County and also to compare the three serological tests, namely; RBPT, indirect ELISA, and competitive ELISA in the detection of seropositive animals. Methods: A cross-sectional study was undertaken in 5 Sub-counties and 13 wards, where a total of 782 serum samples from unvaccinated bovine (n = 278; 34 herds), ovine (n =256; 25 flocks), and caprine (n = 248; 28 flocks), were screened for anti-Brucella antibodies using Rose Bengal Plate test (RBPT), indirect ELISA (i-ELISA) and competitive ELISA (c-ELISA) tests, in parallel. Results: Overall animal seroprevalence was 6.91% (54/782); while that for bovine, ovine, and caprine was 18.35% (51/278), 0.78% (2/256) and 0.4% (1/248), respectively. Bovine seroprevalence was 2.2% (6/278), 14.4% (40/278), and 4.7% (13/278) in RBPT, i-ELISA, and c-ELISA tests, respectively; while ovine 0.78% (2/256) and caprine 0.4% (1/248) were positive only in c-ELISA. Bovine herd seropositivity was 67.65% (23/34), whereas ovine and caprine flock seropositivities were 8% (2/25) and 3.6% (1/28), respectively. Conclusion: The findings indicate a moderate seroprevalence of brucellosis in bovine, whilst that of ovine and caprine was low in Kajiado County. Indirect ELISA was found superior to both c-ELISA and RBPT in detecting bovine seropositive animals, while c-ELISA was superior to both RBPT and i-ELISA in detecting seropositive ovines and caprines. These results will contribute to baseline data for further study of Brucella infection and a starting point for the formulation of a strategy for the control of brucellosis in Kajiado County.
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Tomalak, Marek, Tadeusz Malewski, Jianfeng Gu, and Zhan Fa-Qiang. "Description of Bursaphelenchus taphrorychi sp. n. (Nematoda: Parasitaphelenchidae), the second Bursaphelenchus species from larval galleries of the beech bark beetle, Taphrorychus bicolor (Herbst.) (Coleoptera: Curculionidae: Scolytinae), in European beech, Fagus sylvatica L." Nematology 19, no. 10 (2017): 1217–35. http://dx.doi.org/10.1163/15685411-00003121.
Повний текст джерелаАнотація:
Bursaphelenchus taphrorychi sp. n. is described from the bark of European beech, Fagus sylvatica. All propagative stages of the nematode are numerous in larval galleries of the beech bark beetle, Taphrorychus bicolor, while dauer juveniles are transmitted to new breeding trees under the elytra of adult beetles. The new species is characterised by the body length of 782 (717-858) μm in female and 638 (475-789) μm in male, moderately slender body (a = 35.0 (31.7-36.5) and 35.5 (31.4-37.1) in female and male, respectively), spicules 12.0-16.0 μm long, lateral fields with four incisures (i.e., three bands), and the arrangement of the seven male caudal papillae (i.e., a single precloacal ventromedian papilla (P1), one pair of adcloacal ventrosublateral papillae (P2), one postcloacal pair (P3) located at ca 60% of the tail length, posterior to the cloacal aperture, and one pair (P4) of subventral papillae of a similar size as the previous pair, but with somewhat sunken tips, located near base of bursa). In the number and arrangement of caudal papillae, stout and curved spicules with prominent rostrum and condylus, small vulval flap, body narrowed posterior to vulva, four incisures in the lateral fields, and long post-uterine sac, B. taphrorychi sp. n. shares most of the key morphological characters with members of the sexdentati-group. However, the newly described species is unique amongst Bursaphelenchus species of this group by the combination of shape of female tail, shape of spicules, and some other morphometric characters. The close relation of B. taphrorychi sp. n. with members of the sexdentati-group has been confirmed by DNA sequencing and phylogenetic analysis of the 28S rDNA region. The taxonomic separation of the new species is also confirmed by the unique molecular profile of the ITS region (ITS-RFLP). In laboratory rearing, B. taphrorychi sp. n. can develop and reproduce on Botrytis cinerea cultures.
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Jemielita, Thomas, Xiaoyun (Nicole) Li, Bilal Piperdi, Wei Zhou, Thomas Burke, and Cong Chen. "Overall Survival With Second-Line Pembrolizumab in Patients With Non–Small-Cell Lung Cancer: Randomized Phase III Clinical Trial Versus Propensity-Adjusted Real-World Data." JCO Clinical Cancer Informatics, no. 5 (February 2021): 56–65. http://dx.doi.org/10.1200/cci.20.00099.
Повний текст джерелаАнотація:
PURPOSE To compare and characterize overall survival (OS) differences between clinical trial data from the KEYNOTE-010 trial and real-world data (RWD) from the Flatiron Health database in patients with programmed death ligand 1 (PD-L1)–expressing advanced non–small-cell lung cancer (NSCLC) who received second-line pembrolizumab monotherapy. METHODS Clinical trial data were from the randomized phase II/III KEYNOTE-010 trial that enrolled patients from August 28, 2013, to February 27, 2015. At data cutoff for KEYNOTE-010, the median survival follow-up time for pembrolizumab patients was 11.2 months. RWD were from Flatiron Health advanced NSCLC database and included patients who initiated second-line pembrolizumab from January 26, 2015, to February 28, 2019. At data cutoff for Flatiron, the median survival follow-up time for pembrolizumab-treated patients was 6.1 months. Clinical trial data from KEYNOTE-010 and RWD from Flatiron were analyzed without adjustment, with propensity adjustment, and filtered per the main KEYNOTE-010 eligibility criteria (EC) of histologically/cytologically confirmed PD-L1–positive NSCLC, Eastern Cooperative Oncology Group performance status of 0/1, no prior therapy with docetaxel for NSCLC, and laboratory values indicative of adequate organ function in addition to prior line of therapy requirements. RESULTS Among 243 patients from KEYNOTE-010 and 782 from Flatiron, median age was 63 v 68 years, and 64% v 54% were male, respectively. OS data from KEYNOTE-010 and Flatiron were similar without any adjustment (n = 782; hazard ratio [HR], 0.96; 95% CI, 0.80 to 1.15) and after both filtering and propensity adjustment (n = 221; HR, 0.99; 95% CI, 0.73 to 1.34). CONCLUSION Without any adjustment, as well as after applying similar EC and appropriate statistical methods, RWD demonstrated similar effectiveness for pembrolizumab in second-line NSCLC as observed in randomized clinical trials.
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Kawano, Yoji, Takeshi Yoshimura, Daisuke Tsuboi, Saeko Kawabata, Takako Kaneko-Kawano, Hiromichi Shirataki, Tadaomi Takenawa, and Kozo Kaibuchi. "CRMP-2 Is Involved in Kinesin-1-Dependent Transport of the Sra-1/WAVE1 Complex and Axon Formation." Molecular and Cellular Biology 25, no. 22 (November 15, 2005): 9920–35. http://dx.doi.org/10.1128/mcb.25.22.9920-9935.2005.
Повний текст джерелаАнотація:
ABSTRACT A neuron has two types of highly polarized cell processes, the single axon and multiple dendrites. One of the fundamental questions of neurobiology is how neurons acquire such specific and polarized morphologies. During neuronal development, various actin-binding proteins regulate dynamics of actin cytoskeleton in the growth cones of developing axons. The regulation of actin cytoskeleton in the growth cones is thought to be involved in axon outgrowth and axon-dendrite specification. However, it is largely unknown which actin-binding proteins are involved in axon-dendrite specification and how they are transported into the developing axons. We have previously reported that collapsin response mediator protein 2 (CRMP-2) plays a critical role in axon outgrowth and axon-dendrite specification (N. Inagaki, K. Chihara, N. Arimura, C. Menager, Y. Kawano, N. Matsuo, T. Nishimura, M. Amano, and K. Kaibuchi, Nat. Neurosci. 4:781-782, 2001). Here, we found that CRMP-2 interacted with the specifically Rac1-associated protein 1 (Sra-1)/WASP family verprolin-homologous protein 1 (WAVE1) complex, which is a regulator of actin cytoskeleton. The knockdown of Sra-1 and WAVE1 by RNA interference canceled CRMP-2-induced axon outgrowth and multiple-axon formation in cultured hippocampal neurons. We also found that CRMP-2 interacted with the light chain of kinesin-1 and linked kinesin-1 to the Sra-1/WAVE1 complex. The knockdown of CRMP-2 and kinesin-1 delocalized Sra-1 and WAVE1 from the growth cones of axons. These results suggest that CRMP-2 transports the Sra-1/WAVE1 complex to axons in a kinesin-1-dependent manner and thereby regulates axon outgrowth and formation.
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Rolla, Giancarlo. "Reforma de los reglamentos parlamentarios y evolución de la forma de gobierno en Italia." Asamblea. Revista parlamentaria de la Asamblea de Madrid, no. 2 (December 31, 1999): 57–83. http://dx.doi.org/10.59991/rvam/1999/n.2/782.
Повний текст джерелаАнотація:
Sumario: I. CONSIDERACIONES PRELIMINARES SOBRE LOS ESTUDIOS DE DERECHO CONSTITUCIONAL ACERCA DE LOS REGLAMENTOS PARLAMENTARIOS.—II. LAS DIVERSAS ETAPAS DEL PROCESO DE REFORMA DE LOS REGLAMENTOS PARLAMENTARIOS.—1. Los reglamentos parlamentarios anteriores a 1971.—2. Los reglamentos parlamentarios de 1971.—3. Las reformas de los reglamentos parlamentarios en el período 1981-1990. 4. Las reformas de los reglamentos parlamentarios en el período 1996-1999.—III. EL CONTEXTO CONSTITUCIONAL EN EL CUAL SE SITÚA LA MÁS RECIENTE REVISIÓN DE LOS REGLAMENTOS PARLAMENTARIOS. IV. LAS PRINCIPALES INNOVACIONES PRESENTES EN LOS REGLAMENTOS PARLAMENTARIOS.—1. La mejora del proceso decisional.—1.1. La programación de los trabajos parlamentarios.—1.2. La distribución de los tiempos de intervención en los debates.—1.3. La disciplina de las enmiendas. —2. El reforzamiento de los poderes de la oposición.—3. La construcción de un sistema político más homogéneo y menos fragmentado.—3.1. La disciplina de la organización del grupo mixto.—3.2. La introducción de la votación pública como modalidad general de votación en el seno del Parlamento.—4. La mejora de la calidad de la producción legislativa.—4.1. La creación del Comité para la legislación.—4.2. La disciplina de la tramitación legislativa.—V.- BIBLIOGRAFÍA ESENCIAL.
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Hernández-Alcaraz, Cesar, Teresa Shamah-Levy, Martín Romero-Martínez, Jaime Sepúlveda-Amor, Carlos A. Aguilar-Salinas, Juan A. Rivera-Dommarco, David Kershenobich-Stalnikowitz, Mauricio Hernández-Ávila, and Simón Barquera. "Submuestra para el análisis de enfermedades crónicas con biomarcadores, Encuesta Nacional de Salud y Nutrición 2016." Salud Pública de México 62, no. 5, sep-oct (August 29, 2020): 504–10. http://dx.doi.org/10.21149/11306.
Повний текст джерелаАнотація:
Objetivo. Describir la submuestra de adultos para el análisis de biomarcadores de enfermedades crónicas, así como los tamaños de muestra (n) y la representatividad de las mismas en la Encuesta Nacional de Salud y Nutrición 2016. Material y métodos. Se calculó una submuestra con representatividad nacional para la obtención de sangre, suero y orina en adultos. Se comparó la prevalencia de variables de interés para las submuestras. Resultados. Las n obtenidas de suero y orina fueron de 4 000 y 3 782 adultos con al menos un valor en algún marcador bioquímico sérico y marcadores de orina, respectivamente. Esta n varió con el agrupamiento de marcadores y selección por horas de ayuno. No se observaron diferencias en la distribución de las variables de interés entre las muestras de hogar, sangre y orina. Conclusión. Los datos ponderados de las submuestras de marcadores en orina, suero y sangre son comparables con la muestra total de adultos de la encuesta. Los datos de las submuestras permitirán monitorear la distribución de enfermedades crónicas en México, incluidas las alteraciones en función hepática, renal, y consumo de sodio.
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Wang, Li Qiu, Li Hui Zheng, Yang Liu, Shu Ping Sun, Peng Jun Wang, Xin Ting Wang, Yang Yang Hao, and Tian Cheng He. "Two-Membrane-Pieces Sensitizing Technology and Cyanines Sensitized Nano-TiO2 Materials." Advanced Materials Research 785-786 (September 2013): 823–26. http://dx.doi.org/10.4028/www.scientific.net/amr.785-786.823.
Повний текст джерелаАнотація:
Two-membrane-pieces sensitizing method and the corresponding equipments were developed to prepare cyanines sensitized nanoTiO2 photo anode materials. The cyanines were synthesized from N-p-carboxybenzyl-2,3,3-trimethyl-3H-indoleninium-5-sulfonate potassium and squaric acid or 2-chloro-1-formyl-3-(hydroxymethylene) cyclohex-1-ene. The maximum UV-Vis absorption wavelengths of them were 631 nm and 782 nm, respectively. The nanoTiO2 thin films were prepared on ITO conductive glass from tetrabutyl titanate by sol-gel technique, and were sensitized with the dyes by two-membrane-pieces dye sensitizing method or immersion sensitizing method. Compared with traditional immersion sensitizing method, two-membrane-pieces sensitizing method was an environmentally friendly and economical process due to less dye consumption and less waste formed.
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Marengo, Lívia Luize, and Silvio Barberato-Filho. "Involvement of Human Volunteers in the Development and Evaluation of Wearable Devices Designed to Improve Medication Adherence: A Scoping Review." Sensors 23, no. 7 (March 30, 2023): 3597. http://dx.doi.org/10.3390/s23073597.
Повний текст джерелаАнотація:
Wearable devices designed to improve medication adherence can emit audible and vibrating alerts or send text messages to users. However, there is little information on the validation of these technologies. The aim of this scoping review was to investigate the involvement of human volunteers in the development and evaluation of wearable devices. A literature search was conducted using six databases (MEDLINE, Embase, Scopus, CINAHL, PsycInfo, and Web of Science) up to March 2020. A total of 7087 records were identified, and nine studies were included. The wearable technologies most investigated were smartwatches (n = 3), patches (n = 3), wristbands (n = 2), and neckwear (n = 1). The studies involving human volunteers were categorized into idea validation (n = 4); prototype validation (n = 5); and product validation (n = 1). One of them involved human volunteers in idea and prototype validation. A total of 782 participants, ranging from 6 to 252, were included. Only five articles reported prior approval by a research ethics committee. Most studies revealed fragile methodological designs, a lack of a control group, a small number of volunteers, and a short follow-up time. Product validation is essential for regulatory approval and encompasses the assessment of the effectiveness, safety, and performance of a wearable device. Studies with greater methodological rigor and the involvement of human volunteers can contribute to the improvement of the process before making them available on the market.
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Hu, Ren, Zijuan Ding, Tingyu Li, Dingyue Zhang, Yingbing Tian, Yuxian Cao, and Jun Hou. "Optimizing Nitrogen Application for Chinese Ratoon Rice Based on Yield and Reactive Nitrogen Loss." Agriculture 12, no. 7 (July 20, 2022): 1064. http://dx.doi.org/10.3390/agriculture12071064.
Повний текст джерелаАнотація:
Ratoon rice (RR) has been regarded as a labor-saving and beneficial production system. Nitrogen (N) surplus and reactive N losses (Nr losses) are effective environmental indicators used to evaluate the performance of N management. Few studies have assessed N surplus and Nr losses for Chinese RR. In this study, Chinese RR planting areas were divided into South China (SC), the southern part of East China (SEC), Central China (CC), the northern part of East China (NEC), and Southwest China (SW). N surplus and Nr losses were also calculated based on 782 studies using a quadratic model under optimized N management for the highest yield (OPT-yield), the highest N-use efficiency (NUE) (OPT-NUE), and the highest grain N uptake (OPT-N uptake). The RR yields in the five regions ranged from 9.98 to 13.59 t ha−1. The high-yield record was observed in SEC, while the low-yield record was observed in NEC. The highest and the lowest Nr losses were found in NEC and SC, respectively. N surplus was reduced, while the yield was maintained in SEC, CC, NEC, and SW under OPT-yield and OPT-N uptake, and N surplus and Nr losses were reduced in the five regions when targeting the highest NUE. Farmers should be encouraged to plant RR in SEC and CC. RR was also a good choice when N management measures were conducted in three other regions. To achieve a win–win situation for both yield and the environment, OPT-yield could serve to improve the N management of current conventional practices.
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Braun, Lois, Jeffrey Gillman, Emily Hoover, and Michael Russelle. "Nitrogen fertilization for new plantings of hybrid hazelnuts in the Upper Midwest of the United States of America." Canadian Journal of Plant Science 91, no. 4 (July 2011): 773–82. http://dx.doi.org/10.4141/cjps2011-015.
Повний текст джерелаАнотація:
Braun, L. C., Gillman, J. H., Hoover, E. E. and Russelle, M. P. 2011. Nitrogen fertilization for new plantings of hybrid hazelnuts in the Upper Midwest of the United States of America. Can. J. Plant Sci. 91: 773–782. Seed-propagated hybrids of Corylus avellana and C. americana are a potential crop for the Upper Midwest. Current N recommendations for hazelnuts are based on research on clonally propagated C. avellana in Oregon and may not be applicable in the Upper Midwest due to differing soils, climate, and plant genetics. We established three field plots in 2003 to test N fertilization rates on new plantings, with rates up to 33 g N plant−1 as ammonium nitrate applied annually in the spring, starting 2 wk after transplanting. We observed a strong negative linear effect of N rate on plant survival. In the second year we added trials on same-aged plants that had not previously been fertilized and found no N effect on survival. We concluded that waiting 1 yr after transplanting before fertilizing increases plant survival, but even then N requirements during establishment years are very low for hybrid hazelnuts. Standard leaf N concentrations for C. avellana in Oregon are roughly applicable to hybrid hazelnuts, except that the threshold between deficiency and sufficiency should be raised slightly to 1.9% N. The current threshold between deficient and sufficient, 2.2%, should be regarded as a target, rather than as a threshold to be exceeded.
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Eckel, Clemens Enno, Won-Keun Kim, Christina Grothusen, Vedat Tiyerili, Albrecht Elsässer, Dagmar Sötemann, Judith Schlüter, et al. "Comparison of the New-Generation Self-Expanding NAVITOR Transcatheter Heart Valve with Its Predecessor, the PORTICO, in Severe Native Aortic Valve Stenosis." Journal of Clinical Medicine 12, no. 12 (June 12, 2023): 3999. http://dx.doi.org/10.3390/jcm12123999.
Повний текст джерелаАнотація:
Background: Third-generation transcatheter heart valves (THVs) are designed to improve outcomes. Data on the new intra-annular self-expanding NAVITOR are scarce. Aims: The aim of this analysis was to compare outcomes between the PORTICO and the NAVITOR systems. Methods: Data from 782 patients with severe native aortic stenosis treated with PORTICO (n = 645) or NAVITOR (n = 137) from 05/2012 to 09/2022 were evaluated. The clinical and hemodynamic outcomes of 276 patients (PORTICO, n = 139; NAVITOR, n = 137) were evaluated according to VARC-3 recommendations. Results: Rates of postprocedural more-than-mild paravalvular leakage (PVL) were significantly lower for NAVITOR than for PORTICO (7.2% vs. 1.5%, p = 0.041). In addition, severe bleeding rates (27.3% vs. 13.1%, p = 0.005) and major vascular complications (5.8% vs. 0.7%, p = 0.036) were lower in the NAVITOR group. The mean gradients (7 vs. 8 mmHg, p = 0.121) and calculated aortic valve areas (1.90 cm2 vs. 1.99 cm2, p = 0.235) were comparable. Rates of PPI were similarly high in both groups (15.3 vs. 21.6, p = 0.299). Conclusions: The NAVITOR demonstrated favorable in-hospital procedural outcome data, with lower rates of relevant PVL, major vascular complications, and severe bleeding than its predecessor the PORTICO and preserved favorable hemodynamic outcomes.
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Niszczota, Paweł, and Michał Białek. "The effect of gender and parenting daughters on judgments of morally controversial companies." PLOS ONE 16, no. 12 (December 1, 2021): e0260503. http://dx.doi.org/10.1371/journal.pone.0260503.
Повний текст джерелаАнотація:
Earlier findings suggest that men with daughters make judgments and decisions somewhat in line with those made by women. In this paper, we attempt to extend those findings, by testing how gender and parenting daughters affect judgments of the appropriateness of investing in and working for morally controversial companies (“sin stocks”). To do so, in Study 1 (N = 634) we investigate whether women judge the prospect of investing in sin stocks more harshly than men do, and test the hypothesis that men with daughters judge such investments less favorably than other men. In Study 2 (N = 782), we investigate the willingness to work in morally controversial companies at a significant wage premium. Results show that—for men—parenting daughters yields harsher evaluations of sin stocks, but no evidence that it lowers the propensity to work in such companies. This contrasts to the effect of gender: women reliably judge both investment and employment in morally controversial companies more harshly than men do. We suggest that an aversion towards morally controversial companies might be a partial determinant of the gender gap in wages.
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Ozturk, Mustafa, Lutfu Askın, Emrah Ipek, Selami Demirelli, Oguzhan Ekrem Turan, Erkan Yıldırım, Emrah Ermis, Kamuran Kalkan, and Orhan Delice. "The Role of Serum Bilirubin Levels in Predicting Troponin Positivity in Non-ST-Segment Elevation Acute Coronary Syndrome." Angiology 68, no. 5 (July 18, 2016): 414–18. http://dx.doi.org/10.1177/0003319716659583.
Повний текст джерелаАнотація:
Data are scant regarding serum bilirubin levels in non-ST-segment elevation acute coronary syndrome (NSTE-ACS). In this study, we evaluated the role of serum bilirubin levels in NSTE-ACS. We enrolled 782 patients who presented to the emergency department with acute chest pain. Patients were divided into 2 groups based on the troponin positivity. Patients with NSTE-ACS who had troponin positivity were included in group 1 (n = 382), and group 2 consisted of the control patients (n = 400). Direct bilirubin (DB) levels (group 1: 0.31 ± 0.37 mg/dL, group 2: 0.20 ± 0.25 mg/dL, P < .001) and total bilirubin (TB) levels (group 1: 0.78 ± 0.56 mg/dL, group 2: 0.62 ± 0.45 mg/dL, P < .001) were significantly higher in group 1. There was a significant and moderate correlation between serum bilirubin levels and admission troponin values ( r = .34, P < .001 for TB and r = .42, P < .001 for DB). These results show that serum bilirubin levels were associated with troponin positivity in patients with NSTE-ACS.
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Richette, Pascal, Pierre Clerson, Laure Périssin, René-Marc Flipo, and Thomas Bardin. "Revisiting comorbidities in gout: a cluster analysis." Annals of the Rheumatic Diseases 74, no. 1 (October 9, 2013): 142–47. http://dx.doi.org/10.1136/annrheumdis-2013-203779.
Повний текст джерелаАнотація:
ObjectivesThe reciprocal links between comorbidities and gout are complex. We used cluster analysis to attempt to identify different phenotypes on the basis of comorbidities in a large cohort of patients with gout.MethodsThis was a cross-sectional multicentre study of 2763 gout patients conducted from November 2010 to May 2011. Cluster analysis was conducted separately for variables and for observations in patients, measuring proximity between variables and identifying homogeneous subgroups of patients. Variables used in both analyses were hypertension, obesity, diabetes, dyslipidaemia, heart failure, coronary heart disease, renal failure, liver disorders and cancer.ResultsComorbidities were common in this large cohort of patients with gout. Abdominal obesity, hypertension, metabolic syndrome and dyslipidaemia increased with gout duration, even after adjustment for age and sex. Five clusters (C1–C5) were found. Cluster C1 (n=332, 12%) consisted of patients with isolated gout and few comorbidities. In C2 (n=483, 17%), all patients were obese, with a high prevalence of hypertension. C3 (n=664, 24%) had the greatest proportion of patients with type 2 diabetes (75%). In C4 (n=782, 28%), almost all patients presented with dyslipidaemia (98%). Finally, C5 (n=502, 18%) consisted of almost all patients with a history of cardiovascular disease and renal failure, with a high rate of patients receiving diuretics.ConclusionsCluster analysis of comorbidities in gout allowed us to identify five different clinical phenotypes, which may reflect different pathophysiological processes in gout.
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Miranda, Georgea Gabriela Barreto, Samuel de Carvalho Chaves-Junior, Matheus Paschoaletto Lopes, Talytha Barbosa da Rocha, Débora Frota Colares, Fábio Augusto Ito, Israel Leal Cavalcante, et al. "Oral mucoceles: A Brazillian Multicenter Study of 1,901 Cases." Brazilian Dental Journal 33, no. 5 (October 2022): 81–90. http://dx.doi.org/10.1590/0103-6440202204965.
Повний текст джерелаАнотація:
Abstract Oral mucocele (OM) is the most common lesion of minor salivary glands. The present study aimed to report the clinical and demographic features of a large series of OMs and identify possible predictive variables associated with the recurrence rate of these lesions. A retrospective descriptive cross-sectional study was performed. A total of 43,754 biopsy records from four pathology services in Brazil were analyzed. All cases of OMs were reviewed, and clinical and demographic data were collected. The study comprised 1,002 females (56.2%) and 782 males (43.8%), with a mean age of 19.8±16.4 years (range: 01-87 years) and a 1.3:1 female-to-male ratio. The lower lip (n=1,160; 67.4%), and floor of the mouth (n=172; 10.0%), were the most common affected sites, presenting clinically as nodules (n=978; 79.4%) of smooth surface (n=428; 77.5%) and normal color (n=768, 46.7%). Excisional biopsy was the treatment in most cases (n=1,392; 78.0%). Recurrent OMs represented 6.2% of all diagnosed cases (n=117). OMs recurred more commonly in younger patients (aged<20 years) (p<0.0001), in lesions larger than 2 cm in diameter (p<0.0001), and in those located in the ventral tongue (p=0.0351). Also, recurrence rates were higher significantly in cases treated with laser surgery than in those with conventional surgery (p=0.0005). Patients with OMs should be carefully informed of its possible recurrence, especially when found on the ventral tongue of young patients.
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AKTAŞ, Emine Feyza, and İbrahim YILDIRIM. "Eş Desteği, Kardeş İlişkisi, Akran İlişkisi ve Ebeveyn Öz-Yetkinliğinin Ebeveyn-Ergen İlişkisine Etkisi." Cukurova University Faculty of Education Journal 51, no. 2 (August 31, 2022): 1012–42. http://dx.doi.org/10.14812/cuefd.955694.
Повний текст джерелаАнотація:
Bu çalışmada ebeveyn-ergen ilişkisini etkileyen faktörleri belirlemeye odaklanan bir model geliştirilmesi amaçlanmıştır. Bu faktörlerin belirlenmesi amacıyla yapısal eşitlik modeli kullanılmıştır. Araştırmada ekolojik yaklaşım temelinde ebeveyn-ergen ilişkisini etkileyen değişkenlerden eş desteği, kardeş ilişkileri, akran ilişkileri ve ebeveyn öz-yetkinliği değişkenleri ele alınmıştır. Çalışma grubu 14-17 yaşları arasında 391 ergen ve ebeveynlerinden oluşmaktadır (n=782). Model testi sonuçları, eş desteği, akran ilişkisi ve kardeş ilişkisinin ebeveyn-ergen ilişkisi üzerinde olumlu, ebeveyn öz-yetkinliğinin ise ebeveyn-ergen ilişkisi üzerinde olumsuz etkisi olduğunu göstermiştir. Ayrıca ebeveyn öz-yetkinliği, kardeş ilişkisi aracılığıyla ebeveyn-ergen ilişkisini etkilemiştir. Bu bulgular sonucunda ekolojik sistem yaklaşımı temelinde belirlenen değişkenlerin söz konusu ilişkinin niteliği üzerinde doğrudan ve dolaylı etkilerinin olduğu görülmektedir. İleride yapılacak araştırmalarda bu değişkenlerin ebeveyn-ergen ilişkisine yönelik müdahale programlarında ele alınması ve bu ilişkinin diğer yönlerinin ortaya çıkarılması için nitel yöntemlerle incelenmesi önerilebilir.
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Weber, Bernd, Christian Schaper, Daniel Bushey, Marko Rohlfs, Markus Steinfath, Giulio Tononi, Chiara Cirelli, Jens Scholz, and Berthold Bein. "Increased Volatile Anesthetic Requirement in Short-sleeping Drosophila Mutants." Anesthesiology 110, no. 2 (February 1, 2009): 313–16. http://dx.doi.org/10.1097/aln.0b013e3181942df2.
Повний текст джерелаАнотація:
Background Anesthesia and sleep share physiologic and behavioral similarities. The anesthetic requirement of the recently identified Drosophila mutant minisleeper and other Drosophila mutants was investigated. Methods Sleep and wakefulness were determined by measuring activity of individual wild-type and mutant flies. Based on the response of the flies at different concentrations of the volatile anesthetics isoflurane and sevoflurane, concentration-response curves were generated and EC50 values were calculated. Results The average amount of daily sleep in wild-type Drosophila (n = 64) was 965 +/- 15 min, and 1,022 +/- 29 in Na[har](P > 0.05; n = 32) (mean +/- SEM, all P compared to wild-type and other shaker alleles). Sh flies slept 584 +/- 13 min (n = 64, P < 0.01), Sh flies 412 +/- 22 min (n = 32, P < 0.01), and Sh flies 782 +/- 25 min (n = 32, P < 0.01). The EC50 values for isoflurane were 0.706 (95% CI 0.649 to 0.764, n = 661) and for sevoflurane 1.298 (1.180 to 1.416, n = 522) in wild-type Drosophila; 1.599 (1.527 to 1.671, n = 308) and 2.329 (2.177 to 2.482, n = 282) in Sh, 1.306 (1.212 to 1.400, n = 393) and 2.013 (1.868 to 2.158, n = 550) in Sh, 0.957 (0.860 to 1.054, n = 297) and 1.619 (1.508 to 1.731, n = 386) in Sh, and 0.6154 (0.581 to 0.649, n = 360; P < 0.05) and 0.9339 (0.823 to 1.041, n = 274) in Na[har], respectively (all P < 0.01). Conclusions A single-gene mutation in Drosophila that causes an extreme reduction in daily sleep is responsible for a significant increase in the requirement of volatile anesthetics. This suggests that a single gene mutation affects both sleep behavior and anesthesia and sedation.
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Bar, Jair, Emilio Esteban, Delvys Rodríguez-Abreu, Santiago Ponce-Aix, Zsuzsanna Szalai, Enriqueta Felip, Maya Gottfried, et al. "Abstract LB107: Association of circulating free DNA (cfDNA) maximum variant allele frequency (mVAF) levels with clinical outcomes in patients (pts) with metastatic nonsquamous non-small cell lung cancer (NSCLC) treated with pembrolizumab (pembro) + chemotherapy (chemo) in the phase 2 KEYNOTE-782 trial." Cancer Research 84, no. 7_Supplement (April 5, 2024): LB107. http://dx.doi.org/10.1158/1538-7445.am2024-lb107.
Повний текст джерелаАнотація:
Abstract Background: The phase 2 KEYNOTE-782 trial (NCT03664024) was designed to prospectively evaluate plasma-derived biomarkers of response to first-line pembro + chemo in pts with metastatic nonsquamous NSCLC. This exploratory analysis of KEYNOTE-782 evaluated the association of cfDNA mVAF levels with clinical outcomes. Methods: Adults with untreated stage IV nonsquamous NSCLC received pembro 200 mg Q3W + chemo (pemetrexed + carboplatin or cisplatin). cfDNA was isolated from plasma samples collected at baseline (BL) and cycle 2 (C2) and sequenced using a targeted NGS-based assay previously used to assess blood tumor mutational burden from cfDNA for the primary analysis. cfDNA mVAF was quantified for each patient. The associations of BL cfDNA mVAF (all pts) and change in cfDNA mVAF from BL at C2 (pts with ≥1 detectable variant at BL; cfDNA+) as continuous variables with ORR, PFS, and OS were evaluated; 1-sided α was prespecified at 0.05 after multiplicity adjustment. ORR, PFS, and OS were also descriptively evaluated by cfDNA bins (BL mVAF, >0 vs 0; mVAF change from BL, ≥median vs <median). Results: Of 101 pts with evaluable cfDNA samples at BL, 83 (82.2%) were cfDNA+; 74 of these 83 pts had evaluable cfDNA samples at C2. Low BL mVAF was associated with improved ORR, PFS, and OS (P <0.01, each). The area under the receiver operating characteristic curve (AUROC) for discriminating response was 0.61 (95% CI, 0.50-0.72). Among pts with BL mVAF >0 (n = 83) vs 0 (n = 18), ORR (95% CI) was 38.6% (28.1-49.9) vs 55.6% (30.8-78.5), median PFS (95% CI) was 6.6 mo (4.9-9.0) vs 19.7 mo (9.8-not reached [NR]), and median OS (95% CI) was 13.6 mo (9.4-22.5) vs 31.6 mo (20.1-NR). Larger reductions in mVAF from BL at C2 were associated with improved ORR, PFS, and OS (P <0.05, each). The AUROC for discriminating response was 0.69 (95% CI, 0.57-0.82). After adjustment for best overall response, change in mVAF from BL at C2 was not associated with PFS or OS (P >0.05). In a descriptive evaluation for pts with a mVAF change from BL at C2 ≥median of 0.15 (n = 37) vs <median (n="37)," orr="" (95%="" ci)="" was="" 18.9%="" (8.0-35.2)="" vs="" 64.9%="" (47.5-79.8),="" median="" pfs="" 5.1="" mo="" (4.2-11.1)="" 7.2="" (6.2-21.7),="" and="" os="" 12.8="" (7.9-18.1)="" 25.9="" (15.3-nr).="" conclusions:="" in="" pts="" with metastatic nonsquamous NSCLC treated with pembro + chemo, low cfDNA mVAF levels at BL and larger reductions in cfDNA mVAF levels were associated with improved clinical outcomes. However, after correction for clinical response, the prognostic value of cfDNA mVAF reduction was not significant. Further studies are warranted to elucidate the utility of cfDNA for disease monitoring in this setting. Citation Format: Jair Bar, Emilio Esteban, Delvys Rodríguez-Abreu, Santiago Ponce-Aix, Zsuzsanna Szalai, Enriqueta Felip, Maya Gottfried, Mariano Provencio Pulla, Andrew Robinson, Andrea Fülöp, Suman Bannur Rao, D. Ross Camidge, Giovanna Speranza, Nathan Hunkapiller, Robert McDaniel, Byoungsok Jung, David Burkhardt, Ruth Mauntz, Cai Chen, Carol Pena, Razvan Cristescu, Elisha J. Dettman, Steven M. Townson, Julie Kobie, Tibor Csőszi. Association of circulating free DNA (cfDNA) maximum variant allele frequency (mVAF) levels with clinical outcomes in patients (pts) with metastatic nonsquamous non-small cell lung cancer (NSCLC) treated with pembrolizumab (pembro) + chemotherapy (chemo) in the phase 2 KEYNOTE-782 trial [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 2 (Late-Breaking, Clinical Trial, and Invited Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(7_Suppl):Abstract nr LB107.
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Pérez-Herrera, Lucía C., Sergio Moreno-López, Daniel Peñaranda, Elizabeth García, Edgardo Chapman, and Augusto Peñaranda. "Frequency of self-reported allergies at a high-complexity referral hospital in Colombia, a tropical Latin American country." Allergologia et Immunopathologia 49, no. 5 (September 1, 2021): 100–105. http://dx.doi.org/10.15586/aei.v49i5.449.
Повний текст джерелаАнотація:
Background: The frequency of allergic diseases in tropical Latin American populations is poorly understood, and certain particularities can impact their natural history and risk factors. Objective: The study aimed to determine the frequency of self-reported allergies (allergic diseases, drug, and food allergies) in patients who attended the Hospital Universitario Fundación Santa Fe de Bogotá, Colombia. Material and methods: A retrospective study was conducted to assess the frequency of self-reported allergies reported by all the patients who attended an allergy referral center between June and December 2019. Results: A total of 60978 patients were included. Allergic rhinitis was reported by 1.51% (n= 921), asthma by 1.28% (n = 782), and atopic dermatitis by 0.41% (n = 250) of the study population. A higher frequency of self-reported allergic diseases (rhinitis, asthma, and dermatitis) was found in the younger populations, while drug allergies were more frequently reported in adults. The most frequently self-reported drug allergies were penicillin allergy (4.07%, n = 2479), and non-steroidal anti-inflammatory drug (NSAID) allergy (1.85%, n = 1116). The most commonly reported food allergens included shellfish (0.58%), fruits (0.54%), cow’s milk protein (0.37%), and eggs (0.21%). Conclusion: The distribution of food allergens showed a higher frequency of shrimp and fruit allergies compared to previous studies on African, Asian, and Arabic tropical populations that describe a higher predominance of egg and milk allergies. Patients reporting allergic diseases should always be referred to the allergology department for confirmatory testing.
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Cho, Jungsun, Sang Hyun Ihm, and Kyunghee Kim. "THE PHENOTYPE OF ESSENTIAL HYPERTENSION WITH A HIGH LEVEL OF RENIN AND A HIGH LEVEL OF ALDOSTERONE." Journal of Hypertension 42, Suppl 1 (May 2024): e199. http://dx.doi.org/10.1097/01.hjh.0001021448.20817.67.
Повний текст джерелаАнотація:
Objective: Over the years, considerable efforts have been made to divide the large, heterogeneous groups of individuals with essential hypertension into smaller, homogeneous subgroups based on hormonal responses to biological stimuli. This classification has included low-renin hypertension and non-modulators, in which changes in sodium intake do not produce the expected reciprocal changes in the adrenal gland (aldosterone) with normal or high levels of renin. In never treated essential hypertensive patients, we aim to evaluate the hypertensive phenotype according to renin and aldosterone levels. Design and method: Consecutive patients (n=782) with never treated hypertension were enrolled between August 2009 and July 2021. All enrolled patients underwent ambulatory blood pressure monitoring and laboratory tests, including renin and aldosterone levels, and were evaluated for cardiovascular events during a median follow-up of 5 years, excluding patients with primary aldosteronism. Results: Patients were divided into four groups based on renin and aldosterone levels: High renin and aldosterone (n=216), low renin and high aldosterone (n=161), high renin and low aldosterone (n=163), low renin and aldosterone (n=212). The high renin and high aldosterone group was younger and had lower urine Na/K ratio and higher heart rate than those of other groups in this study. Conclusions: Other than low-renin hypertension or nonmodulators, high renin and aldosterone hypertension could be one of the phenotypes of essential hypertension. In addition, renin and aldosterone levels could be helpful in understanding the phenotypes of essential hypertension.
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Uibu, Ere, Kaja Põlluste, Margus Lember, Karolin Toompere, and Mari Kangasniemi. "Planned improvement actions based on patient safety incident reports in Estonian hospitals: a document analysis." BMJ Open Quality 12, no. 2 (May 2023): e002058. http://dx.doi.org/10.1136/bmjoq-2022-002058.
Повний текст джерелаАнотація:
AimAim of this study was to describe and analyse associations of incidents and their improvement actions in hospital setting.MethodsIt was a retrospective document analysis of incident reporting systems’ reports registered during 2018–2019 in two Estonian regional hospitals. Data were extracted, organised, quantified and analysed by statistical methods.ResultsIn total, 1973 incident reports were analysed. The most commonly reported incidents were related to patient violent or self-harming behaviour (n=587), followed by patient accidents (n=379), and 40% of all incidents were non-harm incidents (n=782). Improvement actions were documented in 83% (n=1643) of all the reports and they were focused on (1) direct patient care, (2) staff-related actions; (3) equipment and general protocols and (4) environment and organisational issues. Improvement actions were mostly associated with medication and transfusion treatment and targeted to staff. The second often associated improvement actions were related to patient accidents and were mostly focused on that particular patient’s further care. Improvement actions were mostly planned for incidents with moderate and mild harm, and for incidents involving children and adolescents.ConclusionPatient safety incidents-related improvement actions need to be considered as a strategy for long-term development in patient safety in organisations. It is vital for patient safety that the planned changes related to the reporting will be documented and implemented more visibly. As a result, it will boost the confidence in managers’ work and strengthens all staff’s commitment to patient safety initiatives in an organisation.
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Elati, Khawla, Faten Bouaicha, Mokhtar Dhibi, Boubaker Ben Smida, Moez Mhadhbi, Isaiah Obara, Safa Amairia, et al. "Phenology and phylogeny of Hyalomma spp. ticks infesting one-humped camels (Camelus dromedarius) in the Tunisian Saharan bioclimatic zone." Parasite 28 (2021): 44. http://dx.doi.org/10.1051/parasite/2021038.
Повний текст джерелаАнотація:
In this study, we report the results of a survey of Hyalomma ticks infesting one-humped camels in southern Tunisia. Examinations were conducted every second or third month on 406 camels in Tataouine district from April 2018 to October 2019. A total of 1902 ticks belonging to the genus Hyalomma were collected. The ticks were identified as adult H. impeltatum (41.1%; n = 782), H. dromedarii (32.9%; n = 626), H. excavatum (25.9%; n = 493), and H. marginatum for a single specimen. Although the camels were infested by ticks throughout the year, the highest overall infestation prevalence was observed in April 2018 (p < 0.01). The overall infestation intensity varied between 2.7 and 7.4 ticks/animal. There were no statistically significant differences in tick infestation prevalence based on age categories of the camels, and the overall infestation prevalence was between 82.7% and 97.4%. Female camels were significantly more infested with ticks (88.3%) than males (65.5%) (p < 0.01). The infestation prevalence of camels varied significantly according to the region where sampling took place (p < 0.01), but no correlations were found with abiotic factors. The preferred attachment sites for adult Hyalomma ticks were the sternum (38.3%; n = 729/1902), around the anus (36.2%; n = 689/1902), udder (18.4%; n = 350/1902), and inner thigh (6.9%; n = 132/1902). Morphological classification of ticks was corroborated by sequencing the cytochrome c oxidase I (Cox1) and 16S rDNA genes, and these sequences were also used to infer phylogenetic relationships. A single H. dromedarii seemed to be a natural hybrid with H. rufipes. More attention should be devoted by the veterinary services to the infestation of camels by ticks.
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Lin, Xin Yao, and Margie Lachman. "The Relationship Between Social Media Use and Well-Being: The Mediating Role of Social Support." Innovation in Aging 5, Supplement_1 (December 1, 2021): 425. http://dx.doi.org/10.1093/geroni/igab046.1648.
Повний текст джерелаАнотація:
Abstract Frequent social media usage can have negative effects on well-being, but the mechanisms involved are unclear. This study explored the mediating role of giving and receiving support. Using the Midlife in the United States Refresher eight-day daily diary study (N=782, age 25-75), multilevel structural equation modeling examined the hypothesized relationships at both the within- (intraindividual) and between-person (interindividual) levels. Results showed that at the within-person level, days with more social media use were associated with a larger proportion of time giving support and worse well-being (less positive affect and more stress, negative affect, and loneliness). At the between-person level, more social media use was associated with worse well-being. Giving support, but not receiving support, mediated the relationship between social media use and well-being at the within, but not the between-person level. Discussion focuses on ways to address the negative consequences of social media use related to social connections and well-being.
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Piazza, Jennifer, Jonathan Rush, Eric Cerino, Jacqueline Mogle, Robert Stawski, Susan Charles, and David Almeida. "Daily Financial Thoughts and Indices of Mental and Physical Health: The Importance of Socioeconomic Status." Innovation in Aging 5, Supplement_1 (December 1, 2021): 389. http://dx.doi.org/10.1093/geroni/igab046.1516.
Повний текст джерелаАнотація:
Abstract The current study examined the associations between daily financial thoughts, socioeconomic status (SES), and indices of emotional (positive and negative affect (PA/NA)) and physical health (physical symptoms and cortisol). Participants (N = 782) from the National Study of Daily Experiences, a subsample of the Midlife in the United States Refresher survey, completed daily diary interviews and provided saliva samples, from which cortisol was assayed. Participants who, on average, reported more daily financial thoughts also reported more NA, less PA, more physical symptoms, and had higher cortisol AUCg (all p’s < .05). These effects were more pronounced among people reporting lower SES. Daily fluctuations in financial thoughts also predicted daily fluctuations in NA, PA, and physical symptoms (all p’s <. 01). Again, these associations were more pronounced among people reporting lower SES. Results indicate that intrusive, daily financial thoughts may be one pathway explaining the link between SES and health outcomes.
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Snipes, Daniel J., Jenna M. Calton, Brooke A. Green, Paul B. Perrin, and Eric G. Benotsch. "Rape and Posttraumatic Stress Disorder (PTSD): Examining the Mediating Role of Explicit Sex–Power Beliefs for Men Versus Women." Journal of Interpersonal Violence 32, no. 16 (July 3, 2015): 2453–70. http://dx.doi.org/10.1177/0886260515592618.
Повний текст джерелаАнотація:
Many rape survivors exhibit symptoms of post-traumatic stress disorder (PTSD), and recent literature suggests survivors’ beliefs about sex and control may affect PTSD symptoms. The present study examined beliefs about sex and power as potential mediators of the relationship between rape and PTSD symptoms for men versus women. Participants ( N = 782) reported lifetime history of rape, current PTSD symptoms, and beliefs about sex and power. Women reported higher levels of lifetime history of rape than men (19.7% for women; 9.7% for men). While rape history predicted PTSD symptoms for both genders, beliefs about sex and power were shown to be a significant partial mediator of this relationship for men, but not for women. Results extend the literature on rape and PTSD by suggesting that survivors’ beliefs about sex and power are connected and can affect their PTSD symptoms. Additionally, results illustrate how sexual violence against men may reaffirm male gender roles that entail power and aggression, and ultimately affect trauma recovery.
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Nettlefold, Lindsay, Patti-Jean Naylor, Heather M. Macdonald, and Heather A. McKay. "Scaling up Action Schools! BC: How Does Voltage Drop at Scale Affect Student Level Outcomes? A Cluster Randomized Controlled Trial." International Journal of Environmental Research and Public Health 18, no. 10 (May 13, 2021): 5182. http://dx.doi.org/10.3390/ijerph18105182.
Повний текст джерелаАнотація:
Action Schools! BC (AS! BC) was scaled-up from an efficacy trial to province-wide delivery across 11 years (2004–2015). In this study we: (1) describe strategies that supported implementation and scale-up; (2) evaluate implementation (teachers’ physical activity (PA) delivery) and student’s PA and cardiorespiratory fitness (CRF) within a cluster randomized controlled trial during years 2 and 3 of scale-up; and (3) assess relationships between teacher-level implementation and student-level outcomes. We classified implementation strategies as process, capacity-building or scale-up strategies. Elementary schools (n = 30) were randomized to intervention (INT; 16 schools; 747 students) or usual practice (UP; 14 schools; 782 students). We measured teachers’ PA delivery (n = 179) using weekly logs; students’ PA by questionnaire (n = 30 schools) and accelerometry (n = 9 schools); and students’ CRF by 20-m shuttle run (n = 25 schools). INT teachers delivered more PA than UP teachers in year 1 (+33.8 min/week, 95% CI 12.7, 54.9) but not year 2 (+18.8 min/week, 95% CI −0.8, 38.3). Unadjusted change in CRF was 36% and 27% higher in INT girls and boys, respectively, compared with their UP peers (year 1; effect size 0.28–0.48). Total PA delivered was associated with change in children’s self-reported MVPA (year 1; r = 0.17, p = 0.02). Despite the ‘voltage drop’, scaling-up school-based PA models is feasible and may enhance children’s health. Stakeholders must conceive of new ways to effectively sustain scaled-up health promoting interventions if we are to improve the health of students at a population level. Clinical Trials registration: NCT01412203.
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Cobo Sánchez, José Luis, Antonio Ochando-García, Ian Blanco Mavillard, Francisco Cirera Segura, Rodolfo Crespo Montero, and Rafael Casas Cuestas. "Análisis del impacto de la producción científica de la revista Enfermería Nefrológica entre 1998 y 2017." Enfermería Nefrológica 21, no. 4 (December 12, 2018): 349–58. http://dx.doi.org/10.4321/s2254-28842018000400004.
Повний текст джерелаАнотація:
Introducción: Enfermería Nefrológica es la publicación oficial de la Sociedad Española de Enfermería Nefrológica, que cumple su 20 aniversario. El análisis de los artículos de una revista permite determinar la evolución de una publicación. Objetivo: Analizar la producción científica publicada en la revista Enfermería Nefrológica durante el periodo 1998-2017. Metodología: Estudio bibliométrico descriptivo transversal de la revista Enfermería Nefrológica, del volumen 1 al 20, mediante el software “Publish or Perish” V6. Se analizaron las siguientes variables: número total de artículos y de citas; citas por artículo, por autor, por año; artículos por autor y autores por artículo; AWCR, índice g e índice h. Se realizaron análisis por periodos de 5 años (P1 1998-2002, P2 2003-2007, P3 2008-2011, P4 2012-2017). Resultados: Se analizaron 1198 artículos: P1 n=81 (6,76%), P2 n= 160 (13,35%), P3 n=164 (13,68%), P4 n=793 (66,19%); y 2167 citaciones: P1 n=47 (2,17%), P2 n= 759 (35%), P3 n=782 (36%), P4 n=579 (26,7%). Media de autores por artículo: P1: 1,96, P2: 2,66, P3: 2,82, P4: 3. AWCR: P1: 2.80 (sqrt=1.67) 1.58/autor, P2: 60.33 (sqrt=7.77) 26.58/autor, P3: 93.93 (sqrt=9.69), 35.21/autor, P4: 147.12 (sqrt=12.13), 57.31/autor. Índice h: P1: 4 (a=2.94, m=0.20, 35 citas=74.5% cobertura), P2: 16 (a=2.96, m=1.07, 433 citas=57.0% cobertura), P3: 9 (a=7.15, m=1.50, 116 citas=20.0% cobertura), P4: 11 (g/h=1.22, 133 citas=23.0% cobertura). Conclusiones: La revista Enfermería Nefrológica ha crecido de forma exponencial en los últimos 20 años, tanto en volumen de producción como en calidad y visibilidad, convirtiéndose en la publicación de referencia del cuidado renal en el ámbito hispano-hablante.
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Shchelkanov, Michail Yur'iyevich, Tatyana Vladimirovna Tabakaeva, Pavel Vasilevich Fomenko, Ekaterina Michailovna Kim, Anton Vadimovich Tabakaev, and Irina Vyacheslavovna Galkina. "A retrospective study of Uncinaria stenocephala in domestic dogs: Age, sex distribution, and risk factors." January-2021 14, no. 1 (January 29, 2021): 265–69. http://dx.doi.org/10.14202/vetworld.2021.265-269.
Повний текст джерелаАнотація:
Background and Aim: Uncinaria infection often appears in domestic dogs. In the present study, parasitological examination of fecal samples from 782 dogs were analyzed for the presence of Uncinaria stenocephala. Materials and Methods: Fecal samples were analyzed by means of a standardized flotation method using a saturated salt solution containing NaNO3 (specific gravity 1.38), with a centrifugation step. Results: The highest prevalence rates were found among young adult dogs (8.3%), followed by puppies (5.4%); the lowest prevalence rates were found in dogs older than 3 years (4.3%). The prevalence was 5.8% among female dogs and 7.2% in male dogs. Coinfections with roundworms and protozoan parasites were frequently observed in U. stenocephala-positive dogs (15%). In total, three types of coinfections were registered. Coinfection of U. stenocephala + Sarcocystids oocysts was recorded in 19.1% of the dogs (n=10). This may relate to higher prevalence of S. oocysts in dogs (n=153; 19.5%). There were two cases of coinfection of U. stenocephala + Toxocara canis (3.9%), which may relate to low prevalence of T. canis (3.9 %). One case of coinfection of Dipylidium caninum + U. stenocephala (0.1%) also appeared. Conclusion: The present study showed that male dogs and young dogs were most susceptible to U. stenocephala infection.
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Garzón Mosquera, Julián Camilo, and Gerardo Alonso Araya Vargas. "Metaanálisis: efectos de técnicas de preparación mental basadas en imaginería - hipnosis sobre flow y rendimiento deportivo." Pensar en Movimiento: Revista de Ciencias del Ejercicio y la Salud 18, no. 1 (March 6, 2020): e39287. http://dx.doi.org/10.15517/pensarmov.v18i1.39287.
Повний текст джерелаАнотація:
El presente estudio tiene como objetivo examinar la efectividad de técnicas psicológicas de preparación mental basadas en imaginería o hipnosis sobre el estado de flow, el rendimiento deportivo y su relación, mediante la técnica meta analítica. Se realizó la revisión de literatura en diez bases de datos durante los meses de agosto a octubre de 2017, donde se incluyeron 17 estudios; relacionados con actividades deportivas y estudios que presentan mediciones pretest-postest. Se analizó un TE con diferencia de medias bajo modelo aleatorio. Obteniendo un total de 53 tamaños de efecto (TE) para estado de flow y 62 tamaños de efecto (TE) para rendimiento. Se encontró un TE positivo para el estado de flow (TE= .782; n=52; p< .001) y para el rendimiento (TE= .339; n=60; p<.05), se comprueba la relación positiva entre las dos variables (ρ= .312; p<.05); se establece que variables más relevantes que moderan el tamaño de efecto del estado de flow y el rendimiento son: edad, años de experiencia deportiva, sexo. Se concluye que la imaginería es la técnica psicológica más efectiva para incrementar el estado de flow y el rendimiento, se recomienda realizar investigaciones con diseño experimental puro y contemplar la medición multi-dimensional del estado de flow.
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Bath, Natalie M., Arjang Djamali, Sandesh Parajuli, Didier Mandelbrot, Glen Leverson, Luis Hidalgo, Thomas Ellis, et al. "Induction and Donor Specific Antibodies in Low Immunologic Risk Kidney Transplant Recipients." Kidney360 1, no. 12 (October 1, 2020): 1407–18. http://dx.doi.org/10.34067/kid.0000122020.
Повний текст джерелаАнотація:
BackgroundOptimal induction for patients without pretransplant donor-specific antibodies (DSAs) is poorly defined. The goal of this study was to compare the incidence of de novo DSA (dnDSA) and graft outcomes between induction therapies in patients with a negative virtual crossmatch (VXM).MethodsA retrospective chart review was performed, identifying 782 patients with a negative VXM who underwent kidney transplantation at a single, high-volume institution between January 2013 and May 2017. Kaplan–Meier analysis was used to assess the incidence of dnDSA and allograft survival between induction therapies in this group. dnDSA is defined as the development of new post-transplant DSA, at any MFI level.ResultsInduction therapy included alemtuzumab (N=87, 11%), basiliximab (N=522, 67%), and anti-thymocyte globulin (ATG; N=173, 22%). One-year graft survival was similar between groups (alemtuzumab, 100%; basiliximab, 98%; ATG, 99%). Incidence of acute rejection at 1 year was <2% and not different between the three groups. Alemtuzumab was associated with the highest incidence of dnDSA at 14%, compared with 5% and 8% in basiliximab and ATG groups, respectively, at 1 year (P=0.009). In multivariate regression analyses, alemtuzumab retained its significant association with a dnDSA HR of 2.5 (95% CI, 1.51 to 4.25; P=0.0004).ConclusionsIn summary, alemtuzumab was associated with a higher rate of dnDSA development in patients with a negative VXM; however, this finding was not associated with rejection or graft failure.
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Varimo, Tero, Leo Dunkel, Kirsi Vaaralahti, Päivi J. Miettinen, Matti Hero, and Taneli Raivio. "Circulating makorin ring finger protein 3 levels decline in boys before the clinical onset of puberty." European Journal of Endocrinology 174, no. 6 (June 2016): 785–90. http://dx.doi.org/10.1530/eje-15-1193.
Повний текст джерелаАнотація:
ObjectiveMakorin ring finger protein 3 (MKRN3) gene restrains the hypothalamic–pituitary–gonadal axis. In girls, peripheral levels of MKRN3 decline prior to the onset of puberty. We described longitudinal changes in serum MKRN3 levels in boys before and during puberty and assessed the effect of inhibition of estrogen biosynthesis on MKRN3 levels.DesignLongitudinal serum samples from a double-blind, randomized controlled study in 30 boys (age range: 9.1–14.2years) with idiopathic short stature who received placebo (Pl;n=14) or aromatase inhibitor letrozole (Lz; 2.5mg/day;n=16) for 2years.MethodsWe analyzed the relationships between serum MKRN3 and clinical and biochemical markers of puberty by using summary measures.ResultsSerum MKRN3 declined by 669±713 pg/mL per year (P<0.001). This change was biphasic, as the levels decreased during Tanner genital stage G1 (–2931±2750 pg/mL per year) and plateaued thereafter (–560±1510 pg/mL per year) (P<0.05). During G1, MKRN3 levels in Lz-treated subjects decreased slower than in Pl-treated boys (–782±3190 vs –2030±821 pg/mL per year,P<0.05). The decrease in serum MKRN3 levels in G1 was associated with increases in LH (r=–0.5,P<0.01), testosterone (r=–0.6,P<0.01), and inhibin B (r=–0.44,P<0.05) (n=26).ConclusionPeripheral MKRN3 levels in boys appear to serve as a readout of the diminishing central inhibition that controls the onset of puberty.
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Santos, Livanio C., Marcos Tavares, José R. F. Silva, Marcelo Cervini, Allysson P. Pinheiro, and William Santana. "A new species of freshwater crab genus Fredius Pretzmann, 1967 (Crustacea: Brachyura: Pseudothelphusidae) from a naturally isolated orographic forest enclave within the semiarid Caatinga in Ceará, northeastern Brazil." PeerJ 8 (June 29, 2020): e9370. http://dx.doi.org/10.7717/peerj.9370.
Повний текст джерелаАнотація:
A new species of freshwater crab, Fredius ibiapaba, is described and illustrated from a mid-altitude forested patch in Ipú (Ibiapaba plateau, Ceará, northeastern Brazil), between 635 to 782 m. The new species can be separated from its congeners by the morphology of its first gonopod: proximal half remarkably swollen, sloping abruptly downwards distally to a nearly right-angular shoulder; mesial lobe much smaller than cephalic spine; cephalic lobe moderately developed; auxiliary lobe lip, delimiting field of apical spines, protruded all the way to distal margin of auxiliary lobe. Comparative 16S rDNA sequencing used to infer the phylogenetic placement of Fredius ibiapaba n. sp. revealed that it is the sister taxon of F. reflexifrons, a species which occurs allopatrically in the Amazon and Atlantic basin’s lowlands (<100 m). Fredius ibiapaba n. sp. and F. reflexifrons are highly dependent upon humidity and most probably were once part of an ancestral population living in a wide humid territory. Shrinking humid forests during several dry periods of the Tertiary and Quaternary likely have resulted in the fragmentation of the ancestral humid area and hence of the ancestral crab population. Fredius reflexifrons evolved and spread in a lowland, humid river basin (Amazon and Atlantic basins), whilst F. ibiapaba n. sp. evolved isolated on the top of a humid plateau. The two species are now separated by a vast intervening area occupied by the semiarid Caatinga
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Møller, Pål, Toni Seppälä, Inge Bernstein, Elke Holinski-Feder, Paola Sala, D. Gareth Evans, Annika Lindblom, et al. "Cancer incidence and survival in Lynch syndrome patients receiving colonoscopic and gynaecological surveillance: first report from the prospective Lynch syndrome database." Gut 66, no. 3 (December 9, 2015): 464–72. http://dx.doi.org/10.1136/gutjnl-2015-309675.
Повний текст джерелаАнотація:
ObjectiveEstimates of cancer risk and the effects of surveillance in Lynch syndrome have been subject to bias, partly through reliance on retrospective studies. We sought to establish more robust estimates in patients undergoing prospective cancer surveillance.DesignWe undertook a multicentre study of patients carrying Lynch syndrome-associated mutations affectingMLH1,MSH2,MSH6orPMS2. Standardised information on surveillance, cancers and outcomes were collated in an Oracle relational database and analysed by age, sex and mutated gene.Results1942 mutation carriers without previous cancer had follow-up including colonoscopic surveillance for 13 782 observation years. 314 patients developed cancer, mostly colorectal (n=151), endometrial (n=72) and ovarian (n=19). Cancers were detected from 25 years onwards inMLH1andMSH2mutation carriers, and from about 40 years inMSH6andPMS2carriers. Among first cancer detected in each patient the colorectal cancer cumulative incidences at 70 years by gene were 46%, 35%, 20% and 10% forMLH1, MSH2, MSH6andPMS2mutation carriers, respectively. The equivalent cumulative incidences for endometrial cancer were 34%, 51%, 49% and 24%; and for ovarian cancer 11%, 15%, 0% and 0%. Ten-year crude survival was 87% after any cancer, 91% if the first cancer was colorectal, 98% if endometrial and 89% if ovarian.ConclusionsThe four Lynch syndrome-associated genes had different penetrance and expression. Colorectal cancer occurred frequently despite colonoscopic surveillance but resulted in few deaths. Using our data, a website has been established athttp://LScarisk.orgenabling calculation of cumulative cancer risks as an aid to genetic counselling in Lynch syndrome.
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Rosales Llontop, Renée, Felipe Guizado Oscco, Ángel Salvatierra MelgaR, Katty Marilyn Juño Príncipe, and Augusto César Mescua Figueroa. "Programa de desarrollo personal para el desarrollo de habilidades sociales en los estudiantes de secundaria." PSIQUEMAG/ Revista Científica Digital de Psicología 9, no. 1 (April 12, 2020): 102–17. http://dx.doi.org/10.18050/psiquemag.v9i1.2497.
Повний текст джерелаАнотація:
El sistema educativo tiene estructurado y organizado cada uno de los aspectos a desarrollar para la formación integral de los estudiantes en el nivel secundaria, dentro de ellos considera el desarrollo de las habilidades sociales, como parte del perfil a lograr en los estudiantes de este nivel, aplicando diversas estrategias. En este contexto el presente estudio plantea como objetivo determinar los efectos del programa de desarrollo personal para el desarrollo de las habilidades sociales de los estudiantes de secundaria. El estudio fue aplicado, de diseño pre experimental. La población estuvo constituida por 782 y la muestra por 636 estudiantes de las instituciones educativas públicas que pertenecen a la UGEL N° 1 de San Juan de Miraflores. La recolección de datos se realizó con dos cuestionarios, validados por juicio de 05 expertos, con una confiabilidad de 0.7; los resultados del programa de desarrollo personal en el desarrollo de habilidades sociales fueron significativos conforme al índice cohen: En asertividad se logró un efecto medio con 0.49, comunicación un efecto medio con 0.38 y toma de decisiones un efecto mayor con 0.69.
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Duckitt, John. "The Reliability and Factorial Validity of a Multidimensional Measure of Psychological Symptomatology in South Africa." South African Journal of Psychology 24, no. 4 (December 1994): 194–200. http://dx.doi.org/10.1177/008124639402400404.
Повний текст джерелаАнотація:
The Psychiatric Symptom Index (PSI) was originally developed and validated on a large sample of Chicago residents as a 29-item self-report measure of psychological distress (Ilfeld, 1976b). It has a number of advantages that make it suitable for use in community surveys: relative brevity, a clear and meaningful multidimensional structure, and promising initial evidence for reliability and validity. Since there appears to have been little cross-validation of the PSI, the present study set out to assess its reliability and factorial validity in a large, nationally representative sample of white South Africans ( N = 782). The findings indicated good internal consistency reliability, and excellent factorial validity for the four subscales of anger, anxiety, depression, and cognitive disturbance. The PSI scales also showed an appropriate degree of independence from each other except for depression and anxiety where the intercorrelation was somewhat high. It was found that shorter depression and anxiety subscales would be adequately reliable and reduce this overlap. Finally, normative data are reported for use with white South African samples.
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Rossignoli, Monica, Paul V. Bernhardt, Geoffrey A. Lawrance, and Marcel Maeder. "Macrocycle Formation Through Carbon Acid - Formaldehyde Condensation Reactions of Bis(propane-1,2-diamine)- and Bis(2-methylpropane-1,2-diamine)-copper(II) Ions." Australian Journal of Chemistry 50, no. 6 (1997): 529. http://dx.doi.org/10.1071/c96219.
Повний текст джерелаАнотація:
The reaction of the bis(1,2-diamine)copper(II) complexes of racemic propane-1,2-diamine (pn) and 2-methylpropane-1,2-diamine (dmen) with formaldehyde and nitroethane in methanol under basic conditions yields minor macrocyclic condensation products in addition to the major acyclic products. Where C-pendant methyl groups on the pair of coordinated diamines are in cis dispositions, the first –NH–CH2–C(CH3)(NO2)–CH2–NH– ring formation occurs at amine pairs distant from these C-methyl substituents, and further reaction to yield a macrocycle is not observed. However, where the C-methyl substituents are in transdispositions, the chemistry proceeds to yield the macrocycle. Commencing with pn, trans-(6,13-diammonio-2,6,9,13-tetramethyl-1,4,7,10-tetraazacyclotetradecane)copper(II) perchlorate formed and crystallized in the space group P 21/n, with a9· 782(2), b 9·2794(6), c 17·017(4) Å, β 103·24(1)°. The copper ion is found in a square-planar environment, with the two methyl groups of the pn residues and the pairs of introduced pendant groups all in trans arrangements.
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Lhee, Sang-Hoon, Rahul Jain, Mohanraj Madathur Sadasivam, Sejun Kim, Moonjung Bae, Jungjin Yu, and Do Young Lee. "Sports injury and illness incidence among South Korean elite athletes in the 2018 Asian Games: a single-physician prospective study of 782 athletes." BMJ Open Sport & Exercise Medicine 7, no. 1 (February 2021): e000689. http://dx.doi.org/10.1136/bmjsem-2019-000689.
Повний текст джерелаАнотація:
ObjectiveThe increasing incidence of sports injury among athletes calls for systemic surveillance of injuries and illnesses in this field to develop preventive measures. The patterns of injuries and illnesses that occurred among Korean athletes during the 2018 Asian Games held in Indonesia were studied.MethodsWe recorded the occurrence of all injuries and illnesses reported to the chief medical officer, coordinated with the help of an instant social messaging application in real time.ResultsA total of 782 elite athletes participated in 46 sporting events. A total of 141 (18.03%) injuries were recorded, with 121 (15.47%) athletes suffering at least one injury. Out of 141 injuries 80 (56.74%) were in male athletes and 61 (43.26%) were in female athletes. The highest number of injuries was seen among sport climbing athletes (n=10, 71.43%), followed by sepak takraw. A total of 16 (11.35%) injuries were expected to prevent athletes from participation in competition/training. Most of the injuries occurred during training (46.10%), with lower lumbar spine being the most common part injured. A total of 209 (26.72%) illnesses were reported, with at least one illness in 170 (21.73%) athletes. The incidence among female athletes (26.90%) was comparable with that of male athletes (26.90%). Maximum illness rate was reported in table tennis (100%). The most common system involved was gastrointestinal (n=93, 44.49%), followed by respiratory (n=53, 25.36%). Environmental factors were causative in 111 athletes (53.11%) and infection in 79 (37.79%). Illnesses resulted in loss of at least 1 day among 30 (14.35%) athletes.ConclusionOverall 15.47% of athletes suffered at least one injury and 21.73% suffered at least one illness; the incidence of injury and illness varied depending on the type of sports.
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Bjarnadottir, O. H., A. D. Konradsdottir, K. Reynisdottir, and E. Olafsson. "Multiple sclerosis and brief moderate exercise. A randomised study." Multiple Sclerosis Journal 13, no. 6 (February 9, 2007): 776–82. http://dx.doi.org/10.1177/1352458506073780.
Повний текст джерелаАнотація:
This is a randomised control study, to determine the effect of aerobic and strength exercise on physical fitness and quality of life in patients with mild multiple sclerosis (MS). Sixteen outpatients with definitive MS, aged 18-50, with an Expanded Disability Status Scale (EDSS) <4, completed the study. Every patient was evaluated according to physical fitness with peak oxygen consumption (V'O2peak ), workload and anaerobic threshold; quality of life (SF-36); and degree of disability (EDSS). The patients were then randomised to an exercise group (EG) (n =6) or a control group (CG) (n = 10). The EG exercised three times a week for five weeks, and the CG did not change their habits regarding exercise. In the EG, the mean change in workload was 0.34 W/kg (95% confidence interval (CI): 0.09-0.58), the mean change in V'O2peak was 4.54 mL/kg per minute (95% CI: 1.65-7.44), and the mean change in anaerobic threshold was 0.32 L/min (95% CI: 0.08-0.57). There was a tendency towards improved quality of life, and no change was detected in the degree of disability. This study confirms that brief, moderate, aerobic exercise improves physical fitness in individuals with mild MS. No evidence was found for worsening of MS symptoms in association with exercises. Multiple Sclerosis 2007; 13: 776-782. http://msj.sagepub.com
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Wasenius, Niko S., Bo A. Isomaa, Bjarne Östman, Johan Söderström, Björn Forsén, Kaj Lahti, Liisa Hakaste, et al. "Low-cost exercise interventions improve long-term cardiometabolic health independently of a family history of type 2 diabetes: a randomized parallel group trial." BMJ Open Diabetes Research & Care 8, no. 2 (November 2020): e001377. http://dx.doi.org/10.1136/bmjdrc-2020-001377.
Повний текст джерелаАнотація:
IntroductionTo investigate the effect of an exercise prescription and a 1-year supervised exercise intervention, and the modifying effect of the family history of type 2 diabetes (FH), on long-term cardiometabolic health.Research design and methodsFor this prospective randomized trial, we recruited non-diabetic participants with poor fitness (n=1072, 30–70 years). Participants were randomly assigned with stratification for FH either in the exercise prescription group (PG, n=144) or the supervised exercise group (EG, n=146) group and compared with a matched control group from the same population study (CON, n=782). The PG and EG received exercise prescriptions. In addition, the EG attended supervised exercise sessions two times a week for 60 min for 12 months. Cardiometabolic risk factors were measured at baseline, 1 year, 5 years, and 6 years. The CON group received no intervention and was measured at baseline and 6 years.ResultsThe EG reduced their body weight, waist circumference, diastolic blood pressure, and low-density lipoprotein-cholesterol (LDL-C) but not physical fitness (p=0.074) or insulin or glucose regulation (p>0.1) compared with the PG at 1 year and 5 years (p≤0.011). The observed differences were attenuated at 6 years; however, participants in the both intervention groups significantly improved their blood pressure, high-density lipoprotein-cholesterol, and insulin sensitivity compared with the population controls (p≤0.003). FH modified LDL-C and waist circumference responses to exercise at 1 year and 5 years.ConclusionsLow-cost physical activity programs have long-term beneficial effects on cardiometabolic health regardless of the FH of diabetes. Given the feasibility and low cost of these programs, they should be advocated to promote cardiometabolic health.Trial registration numberClinicalTrials.gov identifier NCT02131701.