Дисертації з теми "Myo-inositol 1"
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Dai, Zhijie, and 戴志洁. "The role of sodium/myo-inositol cotransporter 1 and myo-inositol in osteogenesis and bone formation." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B43783533.
Повний текст джерелаDai, Zhijie. "The role of sodium/myo-inositol cotransporter 1 and myo-inositol in osteogenesis and bone formation." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B43783533.
Повний текст джерелаChau, Fung-ling Jenny. "Developmental and physiological consequences of sodium/myo-inositol co-transporter 1 deficiency." Click to view the E-thesis via HKUTO, 2005. http://sunzi.lib.hku.hk/hkuto/record/B3549606X.
Повний текст джерелаAnanieva-Stoyanova, Elitsa Antonova. "Identification and Functional Role of Myo-Inositol Polyphosphate 5-Phosphatase Protein Complexes." Diss., Virginia Tech, 2009. http://hdl.handle.net/10919/28028.
Повний текст джерелаPh. D.
Le, Calvez Pierre-Benoit. "Synthesis of novel multisubstrate adducts : putative inhibitors of myo-inositol 1-phosphate synthase." Thesis, Queen's University Belfast, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.527923.
Повний текст джерелаAlves, Karla Shangela da Silva. "Estudo dos nÃveis salivares de mioinositol e quiroinositol em crianÃas saudÃveis e portadores de diabetes infanto- juvenil." Universidade Federal do CearÃ, 2012. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=7224.
Повний текст джерелаA Diabetes mellitus à uma doenÃa de causa mÃltipla, ocorrendo quando hà falta de insulina ou quando a mesma nÃo atua de forma eficaz, causando um aumento da taxa de glicose no sangue (hiperglicemia). Ainda nÃo se sabe precisamente o mecanismo de aÃÃo da insulina, alguns trabalhos sugerem que pode ser possivelmente mediado atravÃs do fosfoglicano inositol (IPGs), cujas algumas formas foram identificadas como: mioinositol e D-quiroinositol. Hà estudos que relacionam a reduÃÃo da glicemia em indivÃduos diabÃticos com o aparecimento desses inositÃis nas secreÃÃes corpÃreas, embora ainda nÃo haja registro de identificaÃÃo dessas molÃculas na composiÃÃo salivar. O objetivo deste estudo foi determinar a relaÃÃo salivar do mioinositol e quiroinositol em crianÃas com diabetes tipo 1 e comparar a presenÃa e concentraÃÃo dessas substÃncias com um grupo de crianÃas sadias (nÃo diabÃticas). Um total de 45 (quarenta e cinco) voluntÃrios, 25 com diabetes tipo 1 descompensados e 20 sadios (nÃo diabÃticos), de ambos os sexos, com idades de 3 a 12 anos, foram selecionados e convidados a participar do estudo. Amostras de saliva foram coletadas e centrifugadas. Os sobrenadantes foram separados, liofilizados e purificados. Logo em seguida, foram analisados por cromatografia lÃquida de alta eficiÃncia (HPLC) para a identificaÃÃo do mioinositol e quiroinositol. A partir dessa anÃlise, foi observado uma menor concentraÃÃo de quiroinositol (p=0,001, Kruskal- Wallis ANOVA seguido por mÃtodo de Dunnâs) e uma maior da concentraÃÃo de mioinositol (p=0,001, Kruskal- Wallis ANOVA seguido por mÃtodo de Dunnâs) nas crianÃas afetadas em comparaÃÃo com as crianÃas saudÃveis. Os pacientes com diabetes tiveram a razÃo mio/quiroinositol maior que do grupo controle (p=0,001, Kruskal- Wallis ANOVA seguido por mÃtodo de Dunnâs) e apresentaram uma correlaÃÃo entre sua proporÃÃo o DM1(p= 0,001). O resultado desse estudo sugere que o mioinositol e o quiroinositol encontrado na saliva de crianÃas com DM1 podem influenciar no controle metabÃlico e desempenhar um papel de marcadores da DM1.
Diabetes mellitus is a disease of multiples causes that occurs either when the pancreas does not produce enough insulin or when the body cannot effectively use the insulin it produces, causing a rise in blood glucose levels (hyperglycemia). It is not clear the action mechanism of insulin but it has been suggested that inositol phosphoglicans, such as myoinositol and D-chiro-inositol, can be important secondary messengers in insulin signal transduction. Although there are some studies linking a reduction in blood glucose levels in diabetic patients with the presence of these inositols in body secretions, there are not reports about the presence of these molecules in salivary composition. Thus, this study aimed to determinate the myoinositol and D-chiro-inositol salivary relation in children with type 1 diabetes and to compare the presence and concentration of these molecules with healthy children (non-diabetic). It has been selected and invited 45 volunteers of both sexes aged 3-12 years, 25 with decompensate type 1 diabetes and 20 healthy children. Saliva samples were collected and centrifuged. The supernatants were separated, purified and lyophilized. The identification of myoinositol and D-chiro-inositol were carried out by means of high-performance liquid chromatography (HPLC). The results showed that children with type 1 diabetes have a lower concentration of D-chiro-inositol and a higher concentration of myoinositol than healthy children. Consequently, the myo/chiro-inositol rate was higher in type 1 diabetes children and there is a correlation between the rate and type 1 diabetes incidence. In conclusion, our data suggests that myoinositol and chiroinositol found in the saliva of children with type 1 diabetes may influence in metabolic control and plays an important role as markers of type 1 diabetes.
Sayer, Lloyd. "A novel approach towards the stereoselective synthesis of inositols and its application in the synthesis of biologically important molecules." Thesis, University of St Andrews, 2016. http://hdl.handle.net/10023/15658.
Повний текст джерелаChopera, Denis Rutendo. "Molecular characterization of XvlNO1, a myo-inositol 1-phosphate synthase gene from Xerophyta viscosa." Master's thesis, University of Cape Town, 2005. http://hdl.handle.net/11427/4249.
Повний текст джерелаMyo-inositol I-phosphate synthase (INO 1) catalyses the conversion of glucose-6-phosphate to myo-inositol I-phosphate, which is subsequently dephosphorylated to myo-inositol. Myo-inositol is a precursor for a number of important metabolites that include membrane components, storage molecules, phytohormones and a variety of osmoprotectants. Xerophyta viscosa Baker (Family Velloziaceae) is a monocotyledonous angiosperm which has the ability to resume full physiological function after desiccation. The full-length cDNA for INO1 from X viscosa was isolated using the RACE technique.
Duthu, Brigitte. "Phosphoranylation de polyols : nouvelle voie d'acces aux myo-inositol phosphates." Toulouse 3, 1988. http://www.theses.fr/1988TOU30129.
Повний текст джерелаHegeman, Carla Elizabeth. "Isolation and Characterization of Soybean Genes Involved in Phytic Acid Metabolism: Phytase and 1-L-myo-Inositol-1-Phosphate Synthase." Diss., Virginia Tech, 1999. http://hdl.handle.net/10919/29906.
Повний текст джерелаPh. D.
Hellinckx, Jessica Athina Verfasser], Thilo Martin [Akademischer Betreuer] [Fuchs, Wolfgang [Gutachter] Liebl, and Thilo M. [Gutachter] Fuchs. "Analyse des Repressors IolR im myo-Inositol-Stoffwechsel von Salmonella enterica serovar Typhimurium / Jessica Athina Hellinckx ; Gutachter: Wolfgang Liebl, Thilo M. Fuchs ; Betreuer: Thilo M. Fuchs." München : Universitätsbibliothek der TU München, 2018. http://nbn-resolving.de/urn:nbn:de:bvb:91-diss-20180118-1364205-1-8.
Повний текст джерелаReinfried, Lutz. "Protonen-Magnet-Resonanz-Spektroskopie (1 H-MRS) mit 3,0 Tesla zur Erfassung cerebraler Metabolite im Frontalhirn depressiver Patienten unter Plazebo-kontrollierter Inositolgabe im Vergleich zu gesunden Probanden." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2006. http://dx.doi.org/10.18452/15478.
Повний текст джерелаObjectives: By means of proton magnetic resonance spectroscopy (1H-MRS) with absolute quantification we wanted to confirm our previous finding of decreased ratios of the metabolites myo-Inositol/total creatine (mI/tCr) in the right frontal brain of depressives. Moreover, we tested the antidepressive effect of oral Inositol ingestion as add-on-therapy. We measured concentrations (mmol/kg ww) of mI, tCr (= Creatine + Phosphocreatine), Choline (Cho) and N-Acetyl-Aspartate (NAA) in the frontal brain. Methods: Single voxels (2x2x2 cm3) in the white matter of the left and right prefrontal region were examined in a three Tesla Bruker Medspec System (STEAM sequence, TR/TE/TM = 6000/20/30 ms). Metabolites were quantified using the LCModel. At baseline, 24 drug-free patients with unipolar depressive episodes were compared to 24 age and sex matched healthy controls. In a double blind, placebo controlled parallel-group design patients received daily 18 grams Inositol or placebo as an add on therapy to Citalopram over four weeks. Results: At baseline, mI, Cho and NAA concentrations showed no significant differences between patients and controls. The treatment with Inositol did not result in any significant differences to the treatment with placebo. Surprisingly the patients showed significant higher tCr concentrations in the left (5.57 ± 0.96 vs. 4.87 ± 0.63; + 15 %, p < 0.01) as well as in the right prefrontal region (5.29 ± 0.92 vs. 4.46 ± 0.41; + 17 %, p < 0.01) compared to controls. The treatment caused a trend towards a decrease of tCr in the left (day 28: 5.05 ± 1.16; – 12 %, p = 0.08) and in the right frontal hemisphere (day 28: 4.61 ± 1.07; – 9 %, p = 0.09) compared to baseline. The differences between the patients’ tCr at day 28 and the tCr of controls were no more significant. Conclusion: We have found a state dependent increase of tCr concentration indicating bifrontal deviations in Creatine transport or ATP synthesis in drug free unipolar depressives.
Chau, Fung-ling Jenny, and 周鳳玲. "Developmental and physiological consequences of sodium/myo-inositolco-transporter 1 deficiency." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B3549606X.
Повний текст джерелаHung, Shin-Hsien, and 洪士賢. "Characterization of Arabidopsis Myo-Inositol-1-Phosphate Synthase gene." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/33075259911753761102.
Повний текст джерела國立成功大學
生物學系碩博士班
91
The MIPS (myo-inositol-1-phosphate synthase)enzyme plays an important physiological role in organisms, catalyzing D-glucose 6-phosphate to MI-1-P (myo-inositol-1-phosphate) that participates many development processes. The genetic analysis of AtMIPS1 gene of Arabidopsis thaliana and examination of its function in embryogenesis were perfomed. The seeds of mips1 mutant, generated by T-DNA were provided by NASC. Using scanning electron microscopy and light microscopy to observe seed morphology, the cell arrangement of seed coat was abnormal and failed to develop to mature embryo. Another mips1 mutant had the different Salk number which obtained from SIGnAL with the same phenotype, proved that the mutant seeds were also caused by the mutation of AtMIPS1 gene. Southern blotting of genomic DNA with AtMIPS1 coding region suggested that AtMIPS1 was a single copy gene in Arabidopsis thaliana. To determine the genotype of mutant seeds, seeds from siliques of normal phenotype T3 plant that cultivated from the normal seeds of T2 plants which had mips1 mutant were collected. The ratio of normal seeds to mutant seeds in each silique were close to 3:1 (X2 = 3.841, P < 0.05), fitting to the law of segregation. This result confirmed that the genotype of normal and mutant seeds in siliques were MIPS1/MIPS1(or MIPS1/mips1) and mips1/mips1, respectively. T2 plant were further allowed to self-pollinate, pollens from plant which had mutant seeds cross to wild type serving as maternal parents. The presence of mutant seeds in siliques from hybriding plants indicated that mips1 was transmitted by pollens. In development processes, the embryo of mutant seed which occurred variants during the stage of globular to heart embryo was observed by using light microscopy. The phenomenon of non-suspensor in mutant heart embryo may be caused by the wrong direction of cell division in embryogenesis. The AtMIPS1 promoter::GUS expression was detected only in embryo. These results suggest that AtMIPS1 gene may play a critical role in embryo development of Arabidopsis thaliana.
Reichstein, Bianca [Verfasser]. "Produktionsverfahren für Di-myo-Inositol-1-1-́phosphat : Isolierung im Technikumsmaßstab und Versuche zur Etablierung eines rekombinanten Sythesesystems in E. coli / vorgelegt von Bianca Reichstein." 2005. http://d-nb.info/978006933/34.
Повний текст джерела