Готові списки джерел за темами / Mycobacterium avium subsp. paratublerculosis

Добірка наукової літератури з теми "Mycobacterium avium subsp. paratublerculosis"

Автор: Grafiati
Опубліковано: 10 грудня 2022
Оновлено: 28 січня 2023

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Статті в журналах з теми "Mycobacterium avium subsp. paratublerculosis"

1

Thorel, M. F., M. Krichevsky, and V. Vincent Levy-Frebault. "Numerical Taxonomy of Mycobactin-Dependent Mycobacteria, Emended Description of Mycobacterium avium, and Description of Mycobacterium avium subsp. avium subsp. nov., Mycobacterium avium subsp. paratuberculosis subsp. nov., and Mycobacterium avium subsp. silvaticum subsp. nov." International Journal of Systematic Bacteriology 40, no. 3 (July 1, 1990): 254–60. http://dx.doi.org/10.1099/00207713-40-3-254.

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Weiss, Douglas J., Oral A. Evanson, Andreas Moritz, Ming Qi Deng, and Mitchell S. Abrahamsen. "Differential Responses of Bovine Macrophages to Mycobacterium avium subsp. paratuberculosis and Mycobacterium avium subsp. avium." Infection and Immunity 70, no. 10 (October 2002): 5556–61. http://dx.doi.org/10.1128/iai.70.10.5556-5561.2002.

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ABSTRACT Mycobacterium avium subsp. paratuberculosis and Mycobacterium avium subsp. avium are antigenically and genetically similar organisms; however, they differ in their virulence for cattle. M. avium subsp. paratuberculosis causes a chronic intestinal infection leading to a chronic wasting disease termed paratuberculosis or Johne's disease, whereas M. avium subsp. avium causes only a transient infection. We compared the response of bovine monocyte-derived macrophages to ingestion of M. avium subsp. paratuberculosis and M. avium subsp. avium organisms by determining organism survival, superoxide and nitric oxide production, and expression of the cytokines tumor necrosis factor alpha (TNF-α), gamma interferon (IFN-γ), interleukin-8 (IL-8), IL-10, IL-12, and granulocyte-monocyte colony-stimulating factor (GM-CSF). Unlike M. avium subsp. paratuberculosis, macrophages were able to kill approximately half of the M. avium subsp. avium organisms after 96 h of incubation. This difference in killing efficiency was not related to differences in nitric oxide or superoxide production. Compared to macrophages activated with IFN-γ and lipopolysaccharide, macrophages incubated with M. avium subsp. paratuberculosis showed greater expression of IL-10 and GM-CSF (all time points) and IL-8 (72 h) and less expression of IL-12 (72 h), IFN-γ (6 h), and TNF-α (6 h). When cytokine expression by macrophages incubated with M. avium subsp. paratuberculosis was compared to those of macrophages incubated with M. avium subsp. avium, M. avium subsp. paratuberculosis-infected cells showed greater expression of IL-10 (6 and 24 h) and less expression of TNF-α (6 h). Therefore, the combination of inherent resistance to intracellular degradation and suppression of macrophage activation through oversecretion of IL-10 may contribute to the virulence of M. avium subsp. paratuberculosis in cattle.
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Paustian, Michael L., Vivek Kapur, and John P. Bannantine. "Comparative Genomic Hybridizations Reveal Genetic Regions within the Mycobacterium avium Complex That Are Divergent from Mycobacterium avium subsp. paratuberculosis Isolates." Journal of Bacteriology 187, no. 7 (April 1, 2005): 2406–15. http://dx.doi.org/10.1128/jb.187.7.2406-2415.2005.

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ABSTRACT Mycobacterium avium subsp. paratuberculosis is genetically similar to other members of the Mycobacterium avium complex (MAC), some of which are nonpathogenic and widespread in the environment. We have utilized an M. avium subsp. paratuberculosis whole-genome microarray representing over 95% of the predicted coding sequences to examine the genetic conservation among 10 M. avium subsp. paratuberculosis isolates, two isolates each of Mycobacterium avium subsp. silvaticum and Mycobacterium avium subsp. avium, and a single isolate each of both Mycobacterium intracellulare and Mycobacterium smegmatis. Genomic DNA from each isolate was competitively hybridized with DNA from M. avium subsp. paratuberculosis K10, and open reading frames (ORFs) were classified as present, divergent, or intermediate. None of the M. avium subsp. paratuberculosis isolates had ORFs classified as divergent. The two M. avium subsp. avium isolates had 210 and 135 divergent ORFs, while the two M. avium subsp. silvaticum isolates examined had 77 and 103 divergent ORFs. Similarly, 130 divergent ORFs were identified in M. intracellulare. A set of 97 ORFs were classified as divergent or intermediate in all of the nonparatuberculosis MAC isolates tested. Many of these ORFs are clustered together on the genome in regions with relatively low average GC content compared with the entire genome and contain mobile genetic elements. One of these regions of sequence divergence contained genes homologous to a mammalian cell entry (mce) operon. Our results indicate that closely related MAC mycobacteria can be distinguished from M. avium subsp. paratuberculosis by multiple clusters of divergent ORFs.
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Stepanova, Hana, Barbora Pavlova, Nikola Stromerova, Petra Ondrackova, Karel Stejskal, Iva Slana, Zbynek Zdrahal, Ivo Pavlik, and Martin Faldyna. "Different immune response of pigs to Mycobacterium avium subsp. avium and Mycobacterium avium subsp. hominissuis infection." Veterinary Microbiology 159, no. 3-4 (October 2012): 343–50. http://dx.doi.org/10.1016/j.vetmic.2012.04.002.

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KLANICOVA, B., I. SLANA, H. VONDRUSKOVA, M. KAEVSKA, and I. PAVLIK. "Real-Time Quantitative PCR Detection of Mycobacterium avium Subspecies in Meat Products." Journal of Food Protection 74, no. 4 (April 1, 2011): 636–40. http://dx.doi.org/10.4315/0362-028x.jfp-10-332.

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The aim of this work was to examine various purchased meat products and to find out if any traces of Mycobacterium avium subsp. avium, M. avium subsp. hominissuis, and M. avium subsp. paratuberculosis could be detected in these samples. Analysis of the meat products (raw, cooked, and fermented) was performed using a real-time quantitative PCR (qPCR) method for the detection of specific insertion sequences: duplex qPCR for the detection of IS900 specific for M. avium subsp. paratuberculosis, and triplex qPCR for the detection of IS901 specific for Mycobacterium avium subsp. avium and IS1245 specific for M. avium subsp. hominissuis. Of the 77 analyzed meat samples, 17 (22%) were found to contain M. avium subsp. paratuberculosis DNA, 4 (5%) samples contained Mycobacterium avium subsp. avium DNA, and in 12 (16%) samples M. avium subsp. hominissuis DNA was detected. The concentration of M. avium subsp. paratuberculosis and M. avium subsp. hominissuis DNA in some meat products exceeded 104 genomes per g. Culture examination of these mycobacterial subspecies was negative. By analyzing a range of meat products, we have provided evidence to support the hypothesis that M. avium is present in everyday commodities sold to the general public
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Semret, Makeda, Gary Zhai, Serge Mostowy, Cynthia Cleto, David Alexander, Gerard Cangelosi, Debby Cousins, Desmond M. Collins, Dick van Soolingen, and Marcel A. Behr. "Extensive Genomic Polymorphism within Mycobacterium avium." Journal of Bacteriology 186, no. 18 (September 15, 2004): 6332–34. http://dx.doi.org/10.1128/jb.186.18.6332-6334.2004.

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ABSTRACT We have initiated comparative genomic analysis of Mycobacterium avium subspecies by DNA microarray, uncovering 14 large sequence polymorphisms (LSPs) comprising over 700 kb that distinguish M. avium subsp. avium from M. avium subsp. paratuberculosis. Genes predicted to encode metabolic pathways were overrepresented in the LSPs, and analysis revealed a polymorphism within the mycobactin biosynthesis operon that potentially explains the in vitro mycobactin dependence of M. avium subsp. paratuberculosis.
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LORENCOVA, ALENA, PETRA VASICKOVA, JITKA MAKOVCOVA, and IVA SLANA. "Presence of Mycobacterium avium Subspecies and Hepatitis E Virus in Raw Meat Products." Journal of Food Protection 77, no. 2 (February 1, 2014): 335–38. http://dx.doi.org/10.4315/0362-028x.jfp-13-252.

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Meat and meat products may be the source of various pathogenic and potentially pathogenic agents for humans. We ascertained the occurrence of Mycobacterium avium subsp. paratuberculosis, subsp. avium, and subsp. hominissuis, and hepatitis E virus in retail raw meat products. The DNA of at least one of the target M. avium subspecies was detected in 26 (29.2%) of 89 analyzed samples of meat products. Fourteen (15.7%), 1 (1.1%), and 17 (19.1%) samples contained the DNA of Mycobacterium avium subsp. paratuberculosis, subsp. avium, and subsp. hominissuis, respectively. The number of mycobacterial cells per gram of meat products determined by real-time quantitative PCR ranged from 1.15 × 102 to 6.97 × 103. Mycobacterium chitae and Mycobacterium nonchromogenicum were isolated from three (3.4%) samples. Culture examination was not positive for any M. avium subspecies. Hepatitis E virus RNA was not detected in any of the samples.
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Agdestein, Angelika, Tone B. Johansen, Øyvor Kolbjørnsen, Anne Jørgensen, Berit Djønne, and Ingrid Olsen. "A comparative study of Mycobacterium avium subsp. avium and Mycobacterium avium subsp. hominissuis in experimentally infected pigs." BMC Veterinary Research 8, no. 1 (2012): 11. http://dx.doi.org/10.1186/1746-6148-8-11.

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Bannantine, J. P., E. Baechler, Q. Zhang, L. Li, and V. Kapur. "Genome Scale Comparison of Mycobacterium avium subsp. paratuberculosis with Mycobacterium avium subsp. avium Reveals Potential Diagnostic Sequences." Journal of Clinical Microbiology 40, no. 4 (April 1, 2002): 1303–10. http://dx.doi.org/10.1128/jcm.40.4.1303-1310.2002.

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Svastova, P., I. Pavlik, and M. Bartos. "Rapid differentiation of Mycobacterium avium subsp. avium and Mycobacterium avium subsp. paratuberculosis by amplification of insertion element IS901." Veterinární Medicína 47, No. 5 (March 30, 2012): 117–21. http://dx.doi.org/10.17221/5814-vetmed.

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The aim of this study was to examine the specificity of primers designed to detect the insertion element IS901 commonly used in differentiation of Mycobacterium avium complex strains. This study shows that one of these primers non-specifically anneals to a sequence inside insertion element IS900, specific IS of M. avium subsp. paratuberculosis and to another sequence flanking this element. The resulting non-specific amplicon can be a product of amplification from some M. avium subsp. paratuberculosis strains and can simulate the presence of insertion element IS901 in these strains. However size difference between specific and non-specific amplicons allows such false-positive results to be distinguished. In addition the single PCR allows a rapid and simple differentiation between IS901+ M. avium subsp. avium and M. avium subsp. paratuberculosis strains.
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Дисертації з теми "Mycobacterium avium subsp. paratublerculosis"

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Bono, Marc Enrico. "Ein Beitrag zur lebensmittelhygienischen Bedeutung von Mycobacterium avium subsp. avium /." [S.l.] : [s.n.], 1994. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.

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Schulze, Martina. "Untersuchungen zur Stammdifferenzierung von Mycobacterium avium subsp. paratuberculosis /." Berlin : Mbv, Mensch-und-Buch-Verl, 2009. http://d-nb.info/995894671/04.

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Turenne, Christine. "The evolution of the pathogen «Mycobacterium avium» subsp «paratuberculosis»." Thesis, McGill University, 2009. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=32284.

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Анотація:
The genus Mycobacterium is best recognized for its pathogens M. tuberculosis and M. leprae, the etiologic agents of Tuberculosis and Leprosy. Sequencing of their genomes has revealed an evolutionary process of reductive genomics. Another common species, the M. avium complex (MAC), consists of both environmental isolates that can cause opportunistic infection in humans as well as pathogenic isolates that cause disease primarily in birds and livestock. The basis of this variation in disease phenotypes is unknown. Two genome sequences representing a pathogen of cattle, M. avium subsp. paratuberculosis (MAP) and an opportunistic isolate from a human (M. avium subsp. hominissuis) have served as the foundation for the comparative genomics of MAC. This is complicated by a level of genetic variability one log greater than found within the M. tuberculosis complex (MTBC), and by the existence of other MAC subsets beyond the two sequenced strains. In this thesis, I set out to define the phylogenetic relationships of the various members of MAC and explore the evolutionary processes that led to the emergence of the pathogenic species MAP. An identification scheme was developed to unambiguously brand subsets of MAC, a tool lacking in the past thus hampering data interpretation. Expansion to a multilocus sequence analysis (MLSA) system revealed that the MAC consists of a highly variable group with most of the genotypes belonging to what is considered to be the environmental subset. However, both the avian and MAP pathogens manifested as two separate clones that have independently evolved from their larger subset. The distribution and directionality (insertion or deletion) of large se
Le genre Mycobacterium est mieux reconnu pour ses espèces pathogènes M. tuberculosis et M. leprae, les agents étiologiques de la tuberculose et de la lèpre. Le séquençage de leur génome a indiqué un processus évolutionnaire de réduction génomique. Des autres espèces communes, le complexe M. avium (MAC) est composé de souches environnementales qui peuvent causer des infections opportunistes chez l'homme aussi bien que de souches pathogènes qui causent la maladie principalement chez les oiseaux et le bétail. La base de cette variation phénotypique est inconnue. Deux séquences génomiques représentant le pathogène de bétail M. avium subsp. paratuberculosis (MAP) et un isolat opportuniste d'humain (M. avium subsp. hominissuis) ont servi de base pour la génomique comparative du MAC. Ceci est compliqué par un niveau de variabilité génétique d'un ordre logarithmique plus grand que celui qui se trouve dans le complexe de M. tuberculosis (MTBC), et par l'existence d'autres sous-ensembles de MAC au-delà des deux souches séquençées. Dans cette thèse, je cherche à définir les rapports phylogénétiques des divers membres du MAC et à explorer les processus évolutionnaires qui ont mené à l'apparition de l'espèce pathogène MAP. Une technique d'identification a été développée pour déterminer clairement les sous-ensembles de MAC, un outil dont l'absence par le passé limitait l'analyse des données. La possibilité d'utiliser un système d'analyse par séquençage multi-locus (MLSA) a révélé que le MAC est composé d'un groupe hautement variable avec la plus grande partie des génotypes appartenant à ce que l'on considère comme étant le$
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Mathie, Heather. "Early macrophage response to Mycobacterium avium subspecies paratuberculosis." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/31378.

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Mycobacterium avium subsp. paratuberculosis (MAP) is the causative agent of Johne's disease, a chronic enteritis that has a damaging economic and welfare impact on the livestock industry. Johne's disease in cattle is known to reduce milk yield and carcass value, making it of economic concern to both dairy and beef farmers. In addition, there is cause for concern regarding zoonotic transmission, as there is an unconfirmed but potential relationship between MAP infection and human Crohn's disease, which presents similar clinical symptoms. MAP is most often contracted by neonates through the faecal-oral route, but can also be spread through contact with contaminated milk and colostrum, as well as in utero. Once the host receives an oral dose, the bacteria traverse the gut epithelium and are phagocytosed by gut macrophages residing in the lamina propria and Peyer's patches. MAP are able to evade the macrophage response by resisting intracellular degradation within phagosomes. Infected macrophages respond to the infection by secreting several pro-inflammatory cytokines that drive the downstream immune response and granuloma formation. This work aimed to elucidate key early responses of bovine monocyte derived macrophages (MDM) to MAP infection, and determine the reliability of using the reference strain, K10 (which is likely to have undergone lab adaptation) to model the infection in vitro, by comparing the MDM response to K10 with the response to a recent clinical isolate, C49. At a multiplicity of infection of 5 (MOI 5), there was a significant decrease in K10 intracellular survival (~90%), compared to C49 intracellular survival, over a 24 hour infection time-course. This suggests that K10 may have lost some virulence mechanism through lab adaptation. Understanding the mechanisms of how MDM respond to these two strains could be informative for the design of targeted vaccines When further investigating the MDM response to both strains, it was found that, at MOI 5, MDM infected with K10 secreted higher levels of IL-1β and IL-10, compared to MDM infected with C49. Both cytokines are associated with mycobacterial infection and could perhaps indicate that MDM are more responsive to the K10 strain at early time-points. In addition, MDM infected with K10 produced significantly higher levels of reactive nitrogen species (RNS). RNS are antimicrobial products that can destroy invading pathogens, and have been shown to have bactericidal effects on MAP. The production of RNS could, therefore be a potential mechanism by which MDM are able to kill K10 more efficiently than C49. An additional aim of this project was to understand the importance of the route of phagocytosis in determining the outcome of MAP infection. MDM express several phagocytic receptors, including Fc receptors (FcRs), complement receptors (CR), Ctype lectin receptors and scavenger receptors. This project mainly focused on the role of the mannose receptor (MR) on bacterial uptake and downstream immune responses, as past studies have suggested that other species of mycobacteria such as M. tuberculosis, target the mannose receptor in order to regulate macrophage immune responses. Blocking the MR reduced intracellular survival for both strains of MAP; however, the mechanism by which the MR influences intracellular survival remains poorly understood The effect of opsonisation on MAP prior to uptake by phagocytic cells was also investigated, as presence of opsonins, such a complement proteins and antibody, can change the mechanism by which pathogens are phagocytosed. MAP were incubated in serum from either MAP- negative or MAP- positive cattle, prior to infection and the percentage uptake and survival assessed by performing colony counts. Opsonisation in serum from Johne's negative cattle resulted in marked increase in MAP uptake but not intracellular survival, whereas opsonisation in serum from Johne's positive cattle did not increase uptake but decreased the intracellular survival rate by 24 HPI. This finding highlights a potential protective role of antibody early in the infection process, and could significantly impact how the infection is modelled in future, as anti-MAP antibody may be present in contaminated milk at the point of infection. Taken together, the data presented in this thesis show that bacterial strain has a significant impact on MDM response to MAP infection, which may have important implications for the interpretation of previous studies and the design of future studies investigating host-pathogen interactions in the context of paratuberculosis. Additionally, this work has shown that RNS production and the mechanism of uptake can affect intracellular survival rates, and although this needs further investigation, the findings could have implications for the design of future vaccines.
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Schulze, Martina [Verfasser]. "Untersuchungen zur Stammdifferenzierung von Mycobacterium avium subsp. paratuberculosis / Martina Schulze." Berlin : Freie Universität Berlin, 2009. http://d-nb.info/102370840X/34.

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Lahiri, Annesha [Verfasser]. "The genetic diversity of Mycobacterium avium subsp. hominissuis / Annesha Lahiri." Berlin : Freie Universität Berlin, 2014. http://d-nb.info/1051812402/34.

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Martinho, António Pedro Alegre. "Rastreio de mycobacterium avium subsp. paratuberculosis na doença de Crohn." Master's thesis, [s.n.], 2012. http://hdl.handle.net/10284/3571.

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Trabalho apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Ciências Farmacêuticas
O possível envolvimento de Mycobacterium avium subsp. paratuberculosis (MAP) na etiologia da doença de Crohn tem gerado muita controvérsia ao longo dos anos. A utilização de métodos de identificação por PCR reportou a detecção de MAP em pacientes com doença de Crohn, mas também em indivíduos sem doença. Outros estudos reportam resultados negativos para ambos os grupos. O objectivo deste trabalho foi verificar se na população de doentes estudada se encontrava uma associação entre presença de MAP e DC. Efectuou-se detecção de MAP em 29 amostras de sangue periférico: 11 amostras de pacientes com doença de Crohn e 18 amostras de indivíduos controlos. As amostras foram analisadas por desagregação das células e extracção do DNA tendo sido, de seguida, utilizada a técnica de PCR-nested para amplificação de parte da sequência de inserção IS900, específica do MAP e presente em elevado número de cópias. A análise dos produtos amplificados foi efectuada por electroforese em gel de agarose. DNA de MAP foi detectado em 9 dos 11 pacientes (82%) e 4 dos 18 controlos (22%), o que sugere uma associação entre MAP e DC na população estudada.
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Ghadiali, Alifiya H. "Studies on Mycobacterium avium subsp. paratuberculosis genotypic and phenotypic variations /." Connect to this title online, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1110229469.

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Анотація:
Thesis (Ph. D.)--Ohio State University, 2005.
Document formatted into pages; contains xxi, 216 p. Includes bibliographical references. Abstract available online via OhioLINK's ETD Center; full text release delayed at author's request until 2006 March 9.
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Gray, Patricia Lara-Lynn. "Humoral response to Mycobacterium avium subsp. avium in naturally infected ring-neck doves (Streptopelia risoria)." [College Station, Tex. : Texas A&M University, 2007. http://hdl.handle.net/1969.1/ETD-TAMU-2610.

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Herthnek, David. "Detection and confirmation of Mycobacterium avium subsp. paratuberculosis in clinical samples /." Uppsala : Dept. of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences, 2006. http://epsilon.slu.se/10210535.pdf.

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Книги з теми "Mycobacterium avium subsp. paratublerculosis"

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National Research Council (U.S.) Committee on Diagnosis and Control of Johne's Disease., ed. Diagnosis and control of Johne's disease. Washington, D.C: National Academies Press, 2003.

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Board on Agriculture and Natural Resources, Division on Earth and Life Studies, National Research Council, and Committee on Diagnosis and Control of Johne's Disease. Diagnosis and Control of Johne's Disease. National Academies Press, 2003.

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3

Zinsstag, Jakob, Borna Müller, and Ivo Pavlik. Mycobacterioses. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780198570028.003.0015.

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The Mycobacterium tuberculosis complex MTC is composed of several species of mycobacteria which are M. tuberculosis, the main cause of human tuberculosis, M. canetti, M. africanum, M. microti, M. pinnipedii, M. caprae, and M. bovis. Cattle are the principal host of M. bovis, but a large number of other ruminants and other mammals, particularly wildlife are infected. Human tuberculosis is a global problem of huge proportions. More than 95% of human tuberculosis cases occur in developing and transition countries, of which one third are in Africa but the proportion of cases caused by M. bovis is still not known. Today, bovine tuberculosis (BTB) is re-emerging and threatens the livestock industry in industrialized countries with wildlife reservoirs like the wild tailed deer (Odocoileus virginianus) in the USA or the badger (Meles meles) in the UK. Most developing countries lack the means and capacity for effective control of BTB. A better understanding of its epidemiology is required to identify novel, locally adapted options for control in a given context. BTB in Africa is emphasized here because of the special importance of multiple transmission interfaces between wildlife, livestock and humans.In addition to obligatory pathogenic mycobacteria (esp. members of the MTC), potentially pathogenic mycobacteria (PPM) previously designated as ‘mycobacteria other than tubercle bacilli’ (MOTT) are increasingly important causes of mycobacterioses in humans and animals. Most of them are opportunistic in humans and occur mostly in immunocompromised patients. The mycobacteria that cause human disease are both the M. avium complex (MAC) members and other mycobacterial species MAC members have been detected in more than 95% of cases; this chapter will mainly focus on M. avium subsp. avium, M. a. hominissuis, and M. intracellulare.
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Частини книг з теми "Mycobacterium avium subsp. paratublerculosis"

1

Whittington, Richard. "Cultivation of Mycobacterium avium subsp. paratuberculosis." In Paratuberculosis: organism, disease, control, 266–304. Wallingford: CABI, 2020. http://dx.doi.org/10.1079/9781789243413.0266.

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Rathnaiah, Govardhan, Fernanda M. Shoyama, Evan P. Brenner, Denise K. Zinniel, John P. Bannantine, Srinand Sreevatsan, Ofelia Chacon, and Raúl G. Barletta. "Molecular genetics of Mycobacterium avium subsp. paratuberculosis." In Paratuberculosis: organism, disease, control, 92–103. Wallingford: CABI, 2020. http://dx.doi.org/10.1079/9781789243413.0092.

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Sreevatsan, Srinand, Natalia Cernicchiaro, and Radhey Kaushik. "Mycobacterium avium subsp. paratuberculosis: an Unconventional Pathogen?" In Food-Borne Microbes, 311–21. Washington, DC, USA: ASM Press, 2014. http://dx.doi.org/10.1128/9781555815479.ch17.

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Naser, Saleh A., and Najih A. Naser. "Mycobacterium avium subsp. paratuberculosis and Crohn's Disease." In Emerging Infections 7, 225–45. Washington, DC, USA: ASM Press, 2014. http://dx.doi.org/10.1128/9781555815585.ch13.

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Piras, C., A. Soggiu, L. Bonizzi, A. Urbani, V. Greco, G. F. Greppi, N. Arrigoni, and P. Roncada. "Immunoreactive proteins of Mycobacterium avium subsp. paratuberculosis." In Farm animal proteomics, 169–72. Wageningen: Wageningen Academic Publishers, 2012. http://dx.doi.org/10.3920/978-90-8686-751-6_40.

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Bannantine, John P., and Vivek Kapur. "Proteins and antigens of Mycobacterium avium subsp. Paratuberculosis." In Paratuberculosis: organism, disease, control, 104–19. Wallingford: CABI, 2020. http://dx.doi.org/10.1079/9781789243413.0104.

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Fox, Naomi J., Lesley A. Smith, Karen Stevenson, Ross S. Davidson, Glenn Marion, and Michael R. Hutchings. "Infection of non-ruminant wildlife by Mycobacterium avium subsp. paratuberculosis." In Paratuberculosis: organism, disease, control, 200–212. Wallingford: CABI, 2020. http://dx.doi.org/10.1079/9781789243413.0200.

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Grant, Irene R. "Mycobacterium avium subsp. paratuberculosis in animal-derived foods and the environment." In Paratuberculosis: organism, disease, control, 14–28. Wallingford: CABI, 2020. http://dx.doi.org/10.1079/9781789243413.0014.

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Stevenson, Karen, and Christina Ahlstrom. "Comparative genomics and genomic epidemiology of Mycobacterium avium subsp. paratuberculosis strains." In Paratuberculosis: organism, disease, control, 76–91. Wallingford: CABI, 2020. http://dx.doi.org/10.1079/9781789243413.0076.

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Coussens, Paul, Justin L. DeKuiper, Fernanda M. Shoyama, Evan Brenner, Elise A. Lamont, Edward Kabara, and Srinand Sreevatsan. "Host-pathogen interactions and intracellular survival of Mycobacterium avium subsp. paratuberculosis." In Paratuberculosis: organism, disease, control, 120–38. Wallingford: CABI, 2020. http://dx.doi.org/10.1079/9781789243413.0120.

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Тези доповідей конференцій з теми "Mycobacterium avium subsp. paratublerculosis"

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Seehusen, F., and S. Scherrer. "Ein neuer S-Stamm von Mycobacterium avium subsp. paratuberculosis bei Ziegen in Graubünden – eine morphologische und molekulare Charakterisierung." In 62. Jahrestagung der Fachgruppe Pathologie der Deutschen Veterinärmedizinischen Gesellschaft. Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-1688584.

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Bermudez, L., A. Palmer, J. D. Blanchard, and I. Gonda. "Treatment of Mycobacterium Avium Subsp Hominissus (MAH) Lung Infections in Mice with Intranasally Instilled Liposomal Ciprofloxacin in Combination with Clarithromycin and Ethambutol." In American Thoracic Society 2019 International Conference, May 17-22, 2019 - Dallas, TX. American Thoracic Society, 2019. http://dx.doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2540.

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Звіти організацій з теми "Mycobacterium avium subsp. paratublerculosis"

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Karcher, Elizabeth L., Donald C. Beitz, and Judith R. Stabel. Osteopontin Expression in Periparturient Dairy Cows Naturally Infected with Mycobacterium Avium Subsp. Paratuberculosis. Ames (Iowa): Iowa State University, January 2008. http://dx.doi.org/10.31274/ans_air-180814-843.

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Barkan, Daniel, Yung-Fu Chang, Patrick McDonough, Susan Fubini, and Robin Gleed. Identification of virulence-associated genes in Mycobacterium avium subsp. paratuberculosis by mutant-library construction. United States Department of Agriculture, January 2016. http://dx.doi.org/10.32747/2016.7600046.bard.

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Bradner, Laura K., Judith R. Stabel, Donald C. Beitz, and Suelee Robbe-Austerman. Shedding of Mycobacterium avium subsp. paratuberculosis into Milk and Colostrum of Naturally Infected Dairy Cows over Complete Lactation Cycles. Ames (Iowa): Iowa State University, January 2013. http://dx.doi.org/10.31274/ans_air-180814-118.

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Karcher, Elizabeth L., Donald C. Beitz, and Judith R. Stabel. Parturition Invokes Changes in Peripheral Blood Mononuclear Cell Populations in Holstein Dairy Cows Naturally Infected with Mycobacterium Avium Subsp. Paratuberculosis. Ames (Iowa): Iowa State University, January 2008. http://dx.doi.org/10.31274/ans_air-180814-26.

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Bradner, Laura, Judith R. Stabel, Donald C. Beitz, and Suelee Robbe-Austerman. Optimization of Methods for the Detection of Mycobacterium avium subsp. paratuberculosis in Milk and Colostrum of Naturally Infected Dairy Cows. Ames (Iowa): Iowa State University, January 2012. http://dx.doi.org/10.31274/ans_air-180814-701.

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Karcher, Elizabeth, Donald C. Beitz, and Judy Stabel. Modulation of Cytokine Gene Expression and Secretion during the Periparturient Period in Dairy Cows Naturally Infected with Mycobacterium avium subsp. paratuberculosis. Ames (Iowa): Iowa State University, January 2007. http://dx.doi.org/10.31274/ans_air-180814-752.

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Bradner, Laura K., Judith R. Stabel, Donald C. Beitz, and Suelee Robbe-Austerman. Treatment with Antibiotics is Detrimental to the Recovery of Viable Mycobacterium avium subsp. paratuberculosis Cultured from Milk and Colostrum of Dairy Cows. Ames (Iowa): Iowa State University, January 2013. http://dx.doi.org/10.31274/ans_air-180814-741.

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Shpigel, Nahum, Raul Barletta, Ilan Rosenshine, and Marcelo Chaffer. Identification and characterization of Mycobacterium paratuberculosis virulence genes expressed in vivo by negative selection. United States Department of Agriculture, January 2004. http://dx.doi.org/10.32747/2004.7696510.bard.

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Анотація:
Mycobacterium avium subsp. paratuberculosis (MAP) is the etiological agent of a severe inflammatory bowel disease (IBD) in ruminants, known as Johne’s disease or paratuberculosis. Johne’s disease is considered to be one of the most serious diseases affecting dairy cattle both in Israel and worldwide. Heavy economic losses are incurred by dairy farmers due to the severe effect of subclinical infection on milk production, fertility, lower disease resistance and early culling. Its influence in the United States alone is staggering, causing an estimated loss of $1.5 billion to the agriculture industry every year. Isolation of MAP from intestinal tissue and blood of Crohn's patients has lead to concern that it plays a potential pathogenic role in promoting human IDB including Crohn’s disease. There is great concern following the identification of the organism in animal products and shedding of the organism to the environment by subclinically infected animals. Little is known about the molecular basis for MAP virulence. The goal of the original proposed research was to identify MAP genes that are required for the critical stage of initial infection and colonization of ruminants’ intestine by MAP. We proposed to develop and use signature tag mutagenesis (STM) screen to find MAP genes that are specifically required for survival in ruminants upon experimental infection. This research projected was approved as one-year feasibility study to prove the ability of the research team to establish the animal model for mutant screening and alternative in-vitro cell systems. In Israel, neonatal goat kids were repeatedly inoculated with either one of the following organisms; MAP K-10 strain and three transposon mutants of K-10 which were produced and screened by the US PI. Six months after the commencement of inoculation we have necropsied the goats and taken multiple tissue samples from the jejunum, ileum and mesenteric lymph nodes. Both PCR and histopathology analysis indicated on efficient MAP colonization of all the inoculated animals. We have established several systems in the Israeli PI’s laboratory; these include using IS900 PCR for the identification of MAP and using HSP65-based PCR for the differentiation between MAV and MAP. We used Southern blot analysis for the differentiation among transposon mutants of K-10. In addition the Israeli PI has set up a panel of in-vitro screening systems for MAP mutants. These include assays to test adhesion, phagocytosis and survival of MAP to/within macrophages, assays that determine the rate of MAPinduced apoptosis of macrophages and MAP-induced NO production by macrophages, and assays testing the interference with T cell ã Interferon production and T cell proliferation by MAP infected macrophages (macrophage studies were done in BoMac and RAW cell lines, mouse peritoneal macrophages and bovine peripheral blood monocytes derived macrophages, respectively). All partners involved in this project feel that we are currently on track with this novel, highly challenging and ambitious research project. We have managed to establish the above described research systems that will clearly enable us to achieve the original proposed scientific objectives. We have proven ourselves as excellent collaborative groups with very high levels of complementary expertise. The Israeli groups were very fortunate to work with the US group and in a very short time period to master numerous techniques in the field of Mycobacterium research. The Israeli group has proven its ability to run this complicated animal model. This research, if continued, may elucidate new and basic aspects related to the pathogenesis MAP. In addition the work may identify new targets for vaccine and drug development. Considering the possibility that MAP might be a cause of human Crohn’s disease, better understanding of virulence mechanisms of this organism might also be of public health interest as well.
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