Добірка наукової літератури з теми "Multivalent recognition"
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Статті в журналах з теми "Multivalent recognition"
Heitner, Tara, Noboru Satozawa, Kirk Mclean, David Vogel, Ronald R. Cobb, Bing Liu, Mithra Mahmoudi, et al. "Obligate Multivalent Recognition of Cell Surface Tomoregulin following Selection from a Multivalent Phage Antibody Library." Journal of Biomolecular Screening 11, no. 8 (December 2006): 985–95. http://dx.doi.org/10.1177/1087057106293841.
Повний текст джерелаKim, Hokyung, Hayeon Choi, Yoonji Heo, Cheoljae Kim, Min Kim, and Ki Tae Kim. "Biosensors Based on Bivalent and Multivalent Recognition by Nucleic Acid Scaffolds." Applied Sciences 12, no. 3 (February 7, 2022): 1717. http://dx.doi.org/10.3390/app12031717.
Повний текст джерелаCiuk, Anna K., and Thisbe K. Lindhorst. "Synthesis of carbohydrate-scaffolded thymine glycoconjugates to organize multivalency." Beilstein Journal of Organic Chemistry 11 (May 7, 2015): 668–74. http://dx.doi.org/10.3762/bjoc.11.75.
Повний текст джерелаLim, Choon Woo, Bart Jan Ravoo, and David N. Reinhoudt. "Dynamic multivalent recognition of cyclodextrin vesicles." Chemical Communications, no. 45 (2005): 5627. http://dx.doi.org/10.1039/b510540d.
Повний текст джерелаMahon, Eugene, Teodor Aastrup, and Mihail Barboiu. "Multivalent recognition of lectins by glyconanoparticle systems." Chemical Communications 46, no. 30 (2010): 5491. http://dx.doi.org/10.1039/c002652b.
Повний текст джерелаMouline, Zineb, Eugene Mahon, Emeline Gomez, Veronique Barragan-Montero, Jean-Louis Montero, and Mihail Barboiu. "Entropy-driven lectin-recognition of multivalent glycovesicles." Chem. Commun. 50, no. 6 (2014): 731–33. http://dx.doi.org/10.1039/c3cc47941b.
Повний текст джерелаFiore, Michele, Nathalie Berthet, Olivier Renaudet, and Valessa Barbier. "New glycopolymers as multivalent systems for lectin recognition." MedChemComm 5, no. 8 (2014): 1202–7. http://dx.doi.org/10.1039/c4md00097h.
Повний текст джерелаRiccardi, Claudia, Ettore Napolitano, Domenica Musumeci, and Daniela Montesarchio. "Dimeric and Multimeric DNA Aptamers for Highly Effective Protein Recognition." Molecules 25, no. 22 (November 10, 2020): 5227. http://dx.doi.org/10.3390/molecules25225227.
Повний текст джерелаLee, JuYeon, Yugang Bai, Ullas V. Chembazhi, Shaohong Peng, Kevin Yum, Long M. Luu, Lauren D. Hagler, et al. "Intrinsically cell-penetrating multivalent and multitargeting ligands for myotonic dystrophy type 1." Proceedings of the National Academy of Sciences 116, no. 18 (April 11, 2019): 8709–14. http://dx.doi.org/10.1073/pnas.1820827116.
Повний текст джерелаCarroll, Joseph, Mark Gray, Kevin Bardon, Hiroshi Nakade, and Vincent Rotello. "Multivalent Recognition of Flavin Derivatives Using Polymer Scaffolds." Letters in Organic Chemistry 1, no. 3 (July 1, 2004): 227–30. http://dx.doi.org/10.2174/1570178043400974.
Повний текст джерелаДисертації з теми "Multivalent recognition"
Hughes, P. J. "Multivalent ligand recognition by pentraxins." Thesis, University College London (University of London), 2016. http://discovery.ucl.ac.uk/1473766/.
Повний текст джерелаDalvand, Parastoo. "Multivalent systems based on viologen units : redox behaviour and recognition properties by cucurbit[n]urils." Thesis, Strasbourg, 2015. http://www.theses.fr/2015STRAF051/document.
Повний текст джерелаSupramolecules based on the recognition of redox-active bipyridiniums by cucurbit[n]uril (CB[n]) have been studied. The investigated systems include a [3]-, a [4]- and a [7]pseudorotaxane, each of them composed of a multimeric viologen-based thread molecule and CB[7] or CB[8]. The physicochemical approach emphasized that these systems can be electrochemically switched between a complexed state, defined by the pseudorotaxanes, and an uncomplexed state comprising their components. The disassembly results from intra/intermolecular pimerization of the viologen radicals.A physicochemical approach of pentacoordinated complexes of a phen-strapped porphyrin with azo-arylimidazoles has been undertaken with the aim to use the photoinduced trans-cis isomerization properties of azo-chromophores to dissociate the complexes. Thermal equilibration reinstates the thermodynamically favoured complexes. The strength and the kinetic properties of these pentacoordinated species have been evaluated
Rosencrantz, Ruben R. [Verfasser], Lothar [Akademischer Betreuer] Elling, and Alexander [Akademischer Betreuer] Böker. "Multivalent glycobiomaterials for specific recognition and binding by lectins / Ruben R. Rosencrantz ; Lothar Elling, Alexander Böker." Aachen : Universitätsbibliothek der RWTH Aachen, 2015. http://d-nb.info/1129785130/34.
Повний текст джерелаBachem, Gunnar. "Investigation of Cooperativity between Statistical Rebinding and the Chelate Effect on DNA Scaffolded Multivalent Binders as a Method for Developing High Avidity Ligands to target the C-type Lectin Langerin." Doctoral thesis, Humboldt-Universität zu Berlin, 2021. http://dx.doi.org/10.18452/22787.
Повний текст джерелаTargeting the C-type lectin (CTL) langerin has received increasing attention as a novel immunotherapy strategy due to the capacity of Langerhans cells, which express langerin, to endocytose and cross-present antigens to T-cells. Langerin recognizes pathogens such as viruses, which present carbohydrates in a multivalent fashion to increase avidity as the monovalent carbohydrate ligands only display low affinity for langerin. Inspired by nature, multivalency has therefore been a key tool for overcoming the low affinities of CTL-carbohydrate interactions. In contrast to highly multivalent ligand presentation with undefined arrangements this work strove to optimize ligand economy by designing bivalent ligands that take the distance between the binding sites of the homotrimeric langerin into consideration by precise arrangement of ligands on DNA-based scaffolds. Studying the multivalent mechanisms at work led us to the design of ligands that take both statistical rebinding and the chelate effect into account. The rebinding effect was recognized as a tool that not only increases ligand avidity at a single binding site but in addition can be exploited to amplify the chelate effect. This method provides a solution for overcoming the low or non-existing multivalency effects when bivalently presenting low affinity ligands on a rigid scaffold if high affinity ligands are unavailable. A combination of this arrangement strategy with the development of a first langerin selective glycomimetic ligand led to the most potent molecularly defined langerin binder to date (IC50 = 300 nM). The ligand-PNA-DNA constructs were selectively internalized by langerin expressing cells at nanomolar concentrations and constitute a delivery platform for the future transport of cargo to Langerhans cells.
Pace, Alice. "Functionalization of water-soluble gold nanoparticles for biological applications." Doctoral thesis, Università degli studi di Trieste, 2011. http://hdl.handle.net/10077/4505.
Повний текст джерелаWater-soluble gold nanoparticles represent an appealing scaffold for the preparation of robust and biocompatible bioconjugates. Indeed, many examples of gold nanoparticles-bioconjugates as new materials in several fields as material science, biology and medicine have been reported in the literature. The organic monolayer protecting the metallic core plays a key role in determining the properties of the system as stability, solubility, and specific interactions with biological environment. The present thesis is focused on the functionalization of water-soluble gold nanoparticles in order to develop new tools in diagnostics, drug-delivery and enhanced immuno-sensing. Gold nanoparticles protected by mixtures of ligands of different nature have been taken into consideration in the development of the three main projects of this thesis. The first project is about the synthesis of gold nanoparticles with a gold core of 1.7 nm suited for crystallization, in order to perform diffractometric analysis aimed to solve the structure of larger systems than that already reported and to find other geometries of the gold core. To this aim, gold nanoparticles protected by a monolayer of p-mercaptobenzoic acid have been synthesized, purified and characterized. The choice of an aromatic ligand with a carboxylic group imparts stability to the clusters and plays a strategic role in crystals formation. Crystallization trials under a variety of different conditions and preliminary observations about the stability of the nanoparticles are reported. Up to now suitable crystals for X-ray analysis could not be obtained. The second project is part of an ongoing investigation of the morphological organization of the monolayer protecting gold nanoparticles in order to complete previous studies carried out in our research group. Recent results from our laboratories, obtained by ESR measurements, support the formation of “patches” domains in the mixed-monolayer of water-soluble gold nanoparticles when mixtures of perfluoroalkyl- and alkylthiolates are used to form the monolayer. The complexity of these systems may also be increased introducing functional thiolates in the monolayer in a controlled topology. The preliminary results obtained so far should be completed with other investigations using different methodologies and supported by studies also on flat surfaces. Moreover, to understand the ability of the amphiphilic thiols to phase-segregate, we thought to study also micellar aggregates. The final goal is to use this phase-segregated monolayers to create clusters of functional thiols for multivalent recognition. Water-soluble gold nanoparticles coated by amphiphilic thiols of different lipophobicity have been prepared and characterized, and new ligands suited for the studies on micelles and on 2D self-assembled monolayers have been designed and synthesized. The results of Electron Spin Resonance (ESR), Scanning Tunneling Microscopy (STM) and Atomic Force Microscopy (AFM) studies on these systems are reported and discussed. The third project is aimed to find new synthetic strategies to obtain biocompatible gold nanoparticles presenting multiple bioactive residues for multivalent recognition processes. In particular, a mimetic of the antigen GM3 Ganglioside Lactone with demonstrated antimelanoma reactivity was introduced in the monolayer of water-soluble gold nanoparticles for the development of a biological therapy against cancer. The preparation of nanoparticles of different size and loading of the antigen-mimetic is reported, together with their characterization and the preliminary biological investigations.
Nanoparticelle di oro solubili in mezzi acquosi rappresentano una piattaforma ideale per la sintesi di bioconiugati stabili e compatibili con le cellule. Infatti la letteratura scientifica riporta molti esempi di nanoparticelle di oro coniugate con biomolecole come prototipo di nuovi materiali applicabili in diversi ambiti tra cui la scienza dei materiali, la biologia e la medicina. Il monostrato organico che protegge il nocciolo metallico riveste un ruolo fondamentale nel determinare le proprietà dell’intero sistema quali la stabilità, la solubilità e le eventuali interazioni specifiche con i sistemi biologici. La presente tesi si focalizza sulla funzionalizzazione del monostrato di nanoparticelle di oro idrosolubili finalizzata allo sviluppo di nuovi strumenti ad uso diagnostico, terapeutico, e con applicazione nel sensing immunologico. Nello sviluppo dei tre progetti principali in cui la tesi si articola, sono state studiate nanoparticelle di oro protette da miscele di ligandi di natura diversa. Il primo progetto riguarda la sintesi di nanoparticelle di oro aventi diametro del gold core di 1.7 nm adatte alla cristallizzazione, al fine di effettuare un’analisi diffrattometrica che consentisse di risolvere la struttura di nanoparticelle di dimensioni maggiori rispetto a quelle riportate in letteratura e di individuare caratteristiche strutturali quali ad esempio la geometria del nocciolo di oro. A questo scopo sono state preparate nanoparticelle di oro protette da un monostrato composto da molecole di acido p-mercaptobenzoico, che sono state purificate e caratterizzate. La scelta di un ligando aromatico avente gruppi funzionali carbossilici conferisce particolare stabilità ai clusters e riveste un ruolo strategico nella formazione dei cristalli. Le prove di cristallizzazione in diverse condizioni sperimentali e alcune osservazioni preliminari riguardo la stabilità di queste nanoparticelle sono di seguito riportate. Finora non è stato ancora possibile ottenere cristalli adatti per le analisi diffrattometriche. Il secondo progetto è parte di un’indagine rispetto alla morfologia del monostrato protettivo delle nanoparticelle di oro, finalizzata a completare studi già avviati nel nostro gruppo di ricerca. Recenti risultati ottenuti nei nostri laboratori mediante misure ESR sono fortemente indicativi relativamente alla formazione di domini a “macchie” nel monostrato di nanoparticelle idrosolubili composto da miscele di tiolati alchilici e perfluoro-alchilici. Questi sistemi possono raggiungere un elevato livello di complessità mediante l’introduzione con controllo topologico di tiolati funzionalizzati. Il completamento dei risultati preliminari mediante l’impiego di ulteriori tecniche e il supporto mediante studi su superfici piane è un obiettivo di primaria importanza. Inoltre, la comprensione del fenomeno di segregazione tra tioli anfifilici potrebbe essere agevolata da studi su sistemi di tipo micellare. L’obiettivo finale è l’applicazione di suddetta segregazione di fase nella realizzazione di clusters con monostrati recanti tioli funzionalizzati per il riconoscimento multivalente. Sono state preparate e caratterizzate nanoparticelle di oro idrosolubili protette da tioli anfifilici aventi diversa lipofobicità, e sono stati progettati e sintetizzati nuovi ligandi adatti allo studio su aggregati di tipo micellare e su monostrati bi-dimensionali. I risultati ottenuti mediante Risonanza di Spin Elettronico (ESR), Microscopia a Scansione per effetto Tunnel (STM) e Microscopia a Forza Atomica (AFM) su questi sistemi sono di seguito riportati e discussi. Il terzo progetto è finalizzato alla realizzazione di nanoparticelle biocompatibili coniugate a molteplici unità di composti farmacologicamente attivi per il riconoscimento multivalente. In particolare, un mimetico dell’antigene GM3 Ganglioside Lattone con testata attività antitumorale nei confronti di cellule di melanoma è stato introdotto nel monostrato di nanoparticelle di oro idrosolubili nello sviluppo di una terapia antitumorale di tipo biologico. La sintesi di nanoparticelle di varie dimensioni e con diversa composizione del monostrato organico recanti il mimetico di antigene, ed i risultati ottenuti dai primi test biologici sono qui di seguito riportati.
XXIII Ciclo
1983
Reeh, Philipp. "Dynamic Multivalency For The Recognition Of Protein Surfaces." Doctoral thesis, Universitat Rovira i Virgili, 2014. http://hdl.handle.net/10803/283236.
Повний текст джерелаMastouri, Amira. "Etude des phénomènes de reconnaissance moléculaire spécifique aux interfaces biologiques par AFM : investigation de l'influence de la multivalence sur les interactions sucre-lectine." Phd thesis, Université de Technologie de Compiègne, 2013. http://tel.archives-ouvertes.fr/tel-01067126.
Повний текст джерелаWatts, Brian Edward. "Investigations into Multivalent Ligand Binding Thermodynamics." Diss., 2015. http://hdl.handle.net/10161/9965.
Повний текст джерелаVirtually all biologically relevant functions and processes are mediated by non-covalent, molecular recognition events, demonstrating astonishingly diverse affinities and specificities. Despite extensive research, the origin of affinity and specificity in aqueous solution - specifically the relationship between ligand binding thermodynamics and structure - remains remarkably obscure and is further complicated in the context of multivalent interactions. Multivalency describes the combinatorial interaction of multiple discrete epitopes across multiple binding surfaces where the association is considered as the sum of contributions from each epitope and the consequences of multivalent ligand assembly. Gaining the insight necessary to predictably influence biological processes with novel therapeutics begins with an understanding of the molecular basis of solution-phase interactions, and the thermodynamic parameters that follow from those interactions. Here we continue our efforts to understand the basis of aqueous affinity and the nature of multivalent additivity.
Multivalent additivity is the foundation of fragment-based drug discovery, where small, low affinity ligands are covalently assembled into a single high affinity inhibitor. Such systems are ideally suited for investigating the thermodynamic consequences of multivalent ligand assembly. In the first part of this work, we report the design and synthesis of a fragment-based ligand series for the Grb2-SH2 protein and thermodynamic evaluation of the low affinity ligand fragments compared to the intact, high affinity inhibitor by single and double displacement isothermal titration calorimetry (ITC). Interestingly, our investigations reveal positively cooperative multivalent additivity - a binding free energy of the full ligand greater than the sum of its constituent fragments - that is largely enthalpic in origin. These results contradict the most common theory of multivalent affinity enhancement arising from a "savings" in translational and rotational entropy. The Grb2-SH2 system reported here is the third distinct molecular system in which we have observed enthalpically driven multivalent enhancement of affinity.
Previous research by our group into similar multivalent affinity enhancements in protein-carbohydrate systems - the so-called "cluster glycoside effect" - revealed that evaluation of multivalent interactions in the solution-phase is not straightforward due to the accessibility of two disparate binding motifs: intramolecular, chelate-type binding and intermolecular, aggregative binding. Although a number of powerful techniques for evaluation of solution-phase multivalent interactions have been reported, these bulk techniques are often unable to differentiate between binding modes, obscuring thermodynamic interpretation. In the second part of this work, we report a competitive equilibrium approach to Molecular Recognition Force Microscopy (MRFM) for evaluation of ligand binding at the single-molecule level with potential to preclude aggregative associations. We have optimized surface functionalization strategies and MRFM experimental protocols to evaluate the binding constant of surface- and tip-immobilized single stranded DNA epitopes. Surprisingly, the monovalent affinity of an immobilized species is in remarkable agreement with the solution-phase affinity, suggesting the competitive equilibrium MRFM approach presents a unique opportunity to investigate the nature of multivalent additivity at the single molecule level.
Dissertation
"Application of Multivalent Interactions for Recognition Imaging and Delivery of Therapeutics." Doctoral diss., 2016. http://hdl.handle.net/2286/R.I.39432.
Повний текст джерелаDissertation/Thesis
Doctoral Dissertation Chemistry 2016
Частини книг з теми "Multivalent recognition"
Gupta, Akash, Moumita Ray, and Vincent M. Rotello. "Multivalent Protein Recognition Using Synthetic Receptors." In Multivalency, 229–61. Chichester, UK: John Wiley & Sons, Ltd, 2017. http://dx.doi.org/10.1002/9781119143505.ch10.
Повний текст джерелаVoskuhl, Jens, Ulrike Kauscher, and Bart Jan Ravoo. "Multivalent Molecular Recognition on the Surface of Bilayer Vesicles." In Multivalency, 177–204. Chichester, UK: John Wiley & Sons, Ltd, 2017. http://dx.doi.org/10.1002/9781119143505.ch8.
Повний текст джерелаHo, D. K., J. Y. Ramel, and N. Monmarché. "Multivalent Graph Matching for Symbol Recognition." In Document Analysis and Recognition – ICDAR 2021 Workshops, 488–503. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-86159-9_35.
Повний текст джерелаKiessling, Laura L., Travis Young, and Kathleen H. Mortell. "Multivalency in Protein-Carbohydrate Recognition." In Glycoscience: Chemistry and Chemical Biology I–III, 1817–61. Berlin, Heidelberg: Springer Berlin Heidelberg, 2001. http://dx.doi.org/10.1007/978-3-642-56874-9_42.
Повний текст джерелаKiessling, Laura L., Travis Young, and Kathleen H. Mortell. "Multivalency in Protein-Carbohydrate Recognition." In Glycoscience, 1817–61. Berlin, Heidelberg: Springer Berlin Heidelberg, 2001. http://dx.doi.org/10.1007/978-3-662-11893-1_18.
Повний текст джерелаKiessling, Laura L., Travis Young, Todd D. Gruber, and Kathleen H. Mortell. "Multivalency in Protein–Carbohydrate Recognition." In Glycoscience, 2483–523. Berlin, Heidelberg: Springer Berlin Heidelberg, 2008. http://dx.doi.org/10.1007/978-3-540-30429-6_64.
Повний текст джерелаChabre, Yoann M., and Rene Roy. "Solving Promiscuous Protein Carbohydrate Recognition Domains with Multivalent Glycofullerenes." In Synthesis and Biological Applications of Glycoconjugates, 64–77. BENTHAM SCIENCE PUBLISHERS, 2012. http://dx.doi.org/10.2174/978160805277611101010064.
Повний текст джерелаYamaji, Toshiyuki, Kyoko Nakamura, Shinji Amari, Akemi Suzuki, and Yasuhiro Hashimoto. "Application of a Multivalent Glycoprobe: Characterization of Sugar-Binding Specificity of Siglec Family Proteins." In Recognition of Carbohydrates in Biological Systems, Part B: Specific Applications, 104–13. Elsevier, 2003. http://dx.doi.org/10.1016/s0076-6879(03)01046-2.
Повний текст джерелаТези доповідей конференцій з теми "Multivalent recognition"
Long, Timothy E., Casey L. Elkins, Lars Kilian, Taigyoo Park, Scott R. Trenor, Koji Yamauchi, Ralph H. Colby, Donald J. Leo, and Brian J. Love. "“Reversible Macromolecules” as Scaffolds for Adaptive Structures." In ASME 2003 International Mechanical Engineering Congress and Exposition. ASMEDC, 2003. http://dx.doi.org/10.1115/imece2003-43010.
Повний текст джерела