Дисертації з теми "Multiplets and repeats"
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1
Namjesnik, Dalija. "Origin of seismicity related to a flooded abandoned coal mining district at Gardanne, Provence, France." Electronic Thesis or Diss., Université de Lorraine, 2021. http://www.theses.fr/2021LORR0116.
Анотація:
La fermeture des mines et la gestion post-minière constituent aujourd’hui un défi majeur car les problèmes engendrés peuvent impacter grandement la sécurité publique. Lorsque les mines sont abandonnées, les systèmes de pompage des eaux souterraines sont généralement arrêtés et l’eau qui remplit progressivement les vides peut affecter la stabilité mécanique des structures souterraines. En général, les mécanismes de la sismicité observée dans les districts post-miniers inondés sont mal compris. Cette thèse porte sur l’étude de la sismicité enregistrée à la suite de l’ennoyage de l’ancien bassin houiller de Gardanne, en Provence, fermée en 2003, qui connaît des problèmes importants de sismicité post-minière. La distribution spatio-temporelle des événements sismiques suggère un lien avec les épisodes de précipitations intenses ainsi qu’avec le pompage actif. La connaissance de l’origine et des mécanismes de déclenchement de l’activité sismique est la clé pour l’évaluation des risques sismiques de l’ensemble du bassin de Gardanne. Les travaux de thèse ont porté sur des questions liées à l’identification précise de l’origine de la source sismique en évaluant deux hypothèses, à la détermination du mécanisme derrière la sismicité, et le lien entre la sismicité et le système hydrogéologique, et en améliorant la détection et la localisation de la microsismicité avec un réseau clairsemé. La nouvelle méthodologie de détection et de localisation développée adapte la méthode BTBB (Poiata) basée sur la forme d’onde complète en surmontant les défis du réseau de surveillance sismique clairsemé, et inclut une nouvelle approche d’élimination du bruit de l’ensemble des données continues ainsi qu’un système de classification basé sur la qualité de la localisation. Un comportement sismique sous forme de clusters a été mis en évidence par le nouveau catalogue sismique 2014-2017, qui a ensuite fait l’objet d’une analyse plus approfondie. L’ensemble des résultats sont en faveur de l’origine des sources sismiques sur la faille en dessous de la mine. Les caractéristiques spatio-temporelles des événements sismiques et les occurrences de multiplets/répéteurs ont fourni une image plus claire des structures géologiques actives et ont permis une interprétation préliminaire des mécanismes de déclenchement possible, basée sur la comparaison avec les données hydrologiques. Malgré la compréhension générale du mécanisme de la sismicité, la magnitude maximale des événements qui peuvent être déclenchés est actuellement difficile à quantifier et à prévoir en raison des limites des données disponibles. En tant que perspective et dans le but de mieux comprendre le risque sismique, des observations plus précises de la sismicité, des paramètres mécaniques et des changements de niveau d’eau dans la zone sismique active sont nécessaires pour améliorer la compréhension de ces facteurs et de leur interconnexionThe closure of mines and post-mining management nowadays present a major challenge as the problems that arise can greatly concern public security. When mines are abandoned, groundwater pumping systems are usually stopped and the water which progressively fills the remaining voids can affect the mechanical stability of underground structures. In general, mechanisms of observed seismicity in flooded, post-mining districts have been poorly understood. As a case study, this thesis focused on the abandoned, flooded coal mine in Gardanne, France, which has been experiencing significant post-mining seismicity problems. Seismic activity in Gardanne mine seems to originate from an interaction between rocks and fluids, as spatio-temporal distribution of events suggests the link with intense rainfall events as well as the active pumping. The knowledge on the origin and the triggering mechanisms of the seismic activity in Gréasque and Regagnas sector is the key for seismic hazard assessment of the entire Gardanne basin. Thesis work focused on questions concerning precise identification of seismic source origin evaluating two hypothesis, determination of the mechanism behind the seismicity, link between seismicity and the hydrogeological system, as well as improving of the detection and location of microseismicity with a sparse network. The new developed detection and location methodology adapts the full waveform-based method BTBB by Poiata by overcoming the challenges of the sparse seismic monitoring network, and includes a novel approach for noise removal from continuous dataset as well as location quality-based classification system. The seismicity clustering behaviour was indicated by the new seismic catalogue 2014-2017, which was further analysed more thoroughly. All results are in favour of the origin of the seismic sources on the fault below the mine. Spatial and temporal characteristics of observed seismic events and multiplet and repeater occurrences provided a clearer image of the active geological structures and allowed a preliminary interpretation of possible mechanisms affecting the initiation and driving of the repeating or after-shock like behavior of seismic events, based on comparison with available hydrological data. Despite the general understanding of the mechanism behind the seismicity, the maximum magnitude of the events that can be triggered is at this moment is difficult to quantify and predict due to limitations of available data. As a prospective, in order to better understand the seismic hazard, more accurate observations of the seismicity, mechanical parameters and water level changes in the seismically active zone are required to improve the understanding and the interconnection between these factors
2
Skon, Luke C. "Expanding De Novo Repeat Search to Multiple Spaced Seeds." Miami University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=miami1527860222418868.
3
Wang, Hong-Long. "Multiple comparisons procedures in repeated measures designs." Connect to resource, 1992. http://rave.ohiolink.edu/etdc/view.cgi?acc%5Fnum=osu1243362325.
4
Matsui, Masaru. "Xenopus Kielin : A dorsalizing factor containing multiple chordintype repeats secreted from the embryonic midline." Kyoto University, 2000. http://hdl.handle.net/2433/151421.
5
Mendoza, Baez Maria Angelica. "Genetic Individualization of Cannabis sativa by a Short Tandem Repeat Multiplex System." FIU Digital Commons, 2008. http://digitalcommons.fiu.edu/etd/270.
Анотація:
Cannabis sativa is the most frequently used of all illicit drugs in the United States. Cannabis has been used throughout history for its stems in the production of hemp fiber, for its seed for oil and food, and for its buds and leaves as a psychoactive drug. Short tandem repeats (STRs), were chosen as molecular markers because of their distinct advantages over other genetic methods. STRs are co-dominant, can be standardized such that reproducibility between laboratories can be easily achieved, have a high discrimination power and can be multiplexed. In this study, six STR markers previously described for Cannabis were multiplexed into one reaction. The multiplex reaction was able to individualize 98 Cannabis samples (14 hemp and 84 marijuana, authenticated as originating from 33 of the 50 United States) and detect 29 alleles averaging 4.8 alleles per loci. The data did not relate the samples from the same state to each other. This is the first study to report a single reaction six-plex and apply it to the analysis of almost 100 Cannabis samples of known geographic collection site.
6
Pallmann, Philip Steffen [Verfasser]. "Multiple contrast tests with repeated and multiple endpoints : with biological applications / Philip Steffen Pallmann." Hannover : Technische Informationsbibliothek (TIB), 2016. http://d-nb.info/1112948635/34.
7
Kowalchuk, Rhonda K. D. "Repeated measures multiple comparison procedures with a mixed model analysis." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp03/NQ51642.pdf.
8
Yamashita, Darryl Tadao. "Using multiple imputation in Dunnett's multiple comparison procedure for the one-way repeated measures model /." The Ohio State University, 1993. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487847309051249.
9
Silber, Jennifer Michele. "Programming for the generalization of oral reading fluency a comparison of repeated readings versus repeated readings of multiple exemplars /." Related electronic resource: Current Research at SU : database of SU dissertations, recent titles available full text, 2008. http://wwwlib.umi.com/cr/syr/main.
10
Li, Qie. "A Bayesian Hierarchical Model for Multiple Comparisons in Mixed Models." Bowling Green State University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1342530994.
11
Box, Matthew. "Multiple-locus variable-number tandem-repeat analysis (MLVA) for clonal characterization of methicillin resistant Staphylococcus aureus strains." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2006. https://www.mhsl.uab.edu/dt/2008r/box.pdf.
12
Azzopardi, Laura. "Lymphodepletion with repeated cycles of alemtuzumab and secondary autoimmunity after alemtuzumab treatment of relapsing-remitting multiple sclerosis." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/275142.
Анотація:
Background: Relapsing-remitting multiple sclerosis (RRMS) is an autoimmune inflammatory disorder of the central nervous system, with significant morbidity and mortality. The lymphocyte depleting, anti-CD52 monoclonal antibody alemtuzumab is a highly effective treatment option in RRMS, though associated with high rates of secondary autoimmune disorders. As alemtuzumab is now in routine clinical use, following licensing in Europe and the US, understanding the effects of repeated treatment cycles and reducing the risk of secondary autoimmunity is timely and essential. In this thesis, I explore how repeated treatment impacts the extent of lymphodepletion. I also study the role of soluble CD52, recently described as suppressive via interaction with Siglec-10, in the mechanism of secondary autoimmunity, and determine the biomarker potential of pre-treatment cytokine levels. Findings: CD4 and CD8 lymphocytes are less effectively depleted with repeated treatment cycles. Lymphocyte surface CD52 density was found by flow cytometry to be significantly lower after alemtuzumab treatment, although CD52-negative clones are not seen. In a cytolysis assay, reduced CD52 density was shown to correlate with reduced susceptibility to alemtuzumab. In addition, activated proliferating T lymphocytes, as observed after treatment, downregulated CD52 expression in a gene expression assay and shed the antigen from cell surface as demonstrated by ELISA and flow cytometry. The development of immunoassays to detect and quantify anti-idiotype antibodies to alemtuzumab is presented. The occurrence of antibodies at retreatment did not reduce lymphocyte depletion. A regulatory role for soluble CD52 was not found in suppression assays, and the proportion of antigen-activated CD52hi T cells did not vary between healthy controls and RRMS individuals. Siglec-10 was not seen on cell surface of activated T cells by flow cytometry and gene expression; thus concluding that soluble CD52 does not play a role in post-alemtuzumab induced autoimmunity. Prior to treatment, the only serum cytokine found to distinguish individuals who develop autoimmunity from those who do not was IL-21 (higher in the autoimmune cohort), however currently commercially available IL-21 immunoassays have no utility as predictive biomarker tests.
13
Li, Chih-Lin. "Propensity Score Matching in Observational Studies with Multiple Time Points." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1313420291.
14
Cook, Shaun P. "Are All Sources Equal? Examining the Roles of Aging and the Frontal Lobes on Multiple Types of Source Memory Using a Repeated-Measures Design." Diss., The University of Arizona, 2006. http://hdl.handle.net/10150/195539.
Анотація:
This paper reports a series of experiments designed to compare memory for multiple kinds of source information in young and older adults. The older adults in these studies were classified as having well or poorly functioning frontal lobes. In EXPERIMENTS 1-3, three different sources that provided independent cues to item information were examined using a repeated-measures design. In particular, participants' memory for voice source information, spatial source information, and temporal source information was tested in separate blocks. The results indicated that the performance of both young and older adults depended upon the type of source tested: Voice source memory was superior to spatial source and temporal source memory, which did not differ. There was also an age effect that was mediated by frontal functioning. Only the low frontal older adults showed impairments in source memory. High frontal older adults were equivalent to young. In EXPERIMENT 4, sources that provided redundant cues to item information were investigated. Voice sources and spatial sources were perfectly matched during encoding such that Voice A always came from Location 1 and Voice B always came from Location 2. When sources provided redundant information in this manner, young and high frontal older adults improved their spatial source memory by making use of redundant voice information, whereas the low frontal older adults not only performed more poorly than both young and high frontal older adults, but were unable to benefit from the redundancy. No differences in item memory were found. The findings were interpreted in terms of the executive and working memory functions involved in the integration of various contextual elements of an experience with its content.
15
Bristow, Robert Evan. "THERE IS MORE TO LIFE THAN EXPECTED VALUES: RESULTS OF FREE DISTRIBUTIONS OF MULTIPLE-PLAY GAMBLES." Miami University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=miami1304352729.
16
Alghafri, Rashed Hamdan Nasser h.-binamma. "Development, validation and applications of a novel multiplex assay RM-Yplex amplifying 13 rapidly mutating Y chromosome short tandem repeat regions." Thesis, University of Central Lancashire, 2014. http://clok.uclan.ac.uk/11486/.
Анотація:
A polymerase chain reaction (PCR) multiplex assay capable of amplifying 13 rapidly mutating Y chromosome short tandem repeats (RM Y-STRs) simultaneously was developed and optimised. This multiplex assay which was termed RM-Yplex is the first to include all 13 RM Y-STRs including DYF387S1, DYF399S1, DYF403S1a/b, DYF404S1, DYS449, DYS518, DYS526a/b DYS547, DYS570, DYS576, DYS612, DYS626 and DYS627. A developmental validation was performed following the Scientific Working Group for DNA Analysis Methods (SWGDAM) revised guidelines. Robustness and limitations of the assay were demonstrated through a range of studies including reproducibility, sensitivity, specificity, stability and mixture studies. Appropriate controls were used during the studies that included a number of male and female commercial controls including, 2800M, 9948 and Taqman male controls and 9947A female control. An allelic ladder was developed for the assignment of the alleles. This was done by choosing samples with different alleles, amplifying them and then adjusting the volumes of amplified products in a mixture. The developed mixtures were used to balance the composite ladder. Multiple alleles of the various loci included in the ladder were sequenced. Reference haplotypes were developed for the 5 male samples included in the Y chromosome Standard Reference Material 2395 (SRM2395) using RM-Yplex. The International Society of Forensic Genetics (ISFG) recommendations were followed for adopting allele nomenclature. As part of developmental validation, the assay was included in an external proficiency trial which was concluded successfully. An internal validation of RM-Yplex was carried out at the Department of Forensic Sciences and Criminology Laboratory, Dubai where apart from other studies; application of the assay was demonstrated using non-probative forensic casework samples. The value of RM-Yplex was demonstrated for differentiating close male relatives in a case where a previously used Y-STR multiplex assay had shown identical haplotypes for those individuals. 1160 male individual samples were analysed in this study including UAE, other Arabian Peninsula populations as well as two South Asian populations residing in United Arab Emirates. RM-Yplex haplotypes have extremely high power of discrimination. The haplotype diversity for RM-Yplex haplotype is much more than the existing commercial Y-STR assays. Population studies have been carried out for the Arab, Indian and Pakistani populations. AMOVA was conducted for determining the apportionment of diversity and pairwise FST’s were estimated between populations. These have shown a marked homogeneity within the UAE Arab sub-populations. MDS plots of pairwise FST’s indicated that populations were not grouped significantly in accordance with the geographical locations. A network analysis showed the extent of distribution of haplotypes of various populations and their relationships. A highly sensitive and reliable RM-Yplex multiplex assay has been thus developed, which is expected to help genetic populations studies and forensic casework.
17
Muniz, Franco Romero Silva. "Análise de variabilidade genética em populações segregantes de soja /." Jaboticabal : [s.n.], 2007. http://hdl.handle.net/11449/102817.
Анотація:
Resumo: A variabilidade entre progênies é criada pela segregação cromossômica independente dos genes e pela recombinação genética intracromossomal durante a meiose. O objetivo deste estudo foi analisar a variabilidade derivada de crossing-overs em cruzamentos biparentais (G2 e J2), quádruplos (G4 e J4) e óctuplos (G8 e J8), avaliados em populações segregantes derivadas de parentais contrastantes para resistência ao nematóide de cisto da soja (raça 3) - NCS - e ao oídio - O. A análise foi realizada em populações F2, através de marcadores SSR (single sequence repeat) concentrados em uma região de 55 cM ao redor do gene rmd (resistência ao oídio) e rhg1 (resistência ao NCS). Após o teste dos marcadores, quanto ao polimorfismo, apenas marcadores polimórficos foram utilizados para detectar crossing-over. Todos os marcadores analisados foram não significativos pelo teste de qui-quadrado (P > 0,05), indicando que os valores observados se ajustam à proporção genotípica esperada em F2 (1:2:1). As maiores médias de crossing-over por genótipo foram obtidas para G4 (4,00), no grupo G, e J8 (2,91), no grupo J. Por outro lado, as maiores médias de crossing-over considerando o número de gerações para formar cada população, foram para G2 (2,02) e J8 (0,97). A recombinação entre alelos ocorreu em algumas populações, entretanto para G4 e J8 em 1,89% dos genótipos não ocorreram. Em geral, nos cruzamentos com maior número de parentais envolvidos a ocorrência de crossingover foi maior, sendo satisfatórios na criação de variabilidade. O progresso no melhoramento de soja tem sido alcançado em partes pela criação de novas combinações alélicas dentro dos cromossomos.Abstract: The variability among the progenies is created by chromosome segregation, independent assortment of genes, and intra-chromosomal genetic recombination during meiosis. The objective of this study was to analyze the variability derived from crossovers in soybean biparental (G2 and J2), quadruple (G4 and J4) and octuple (G8 and J8) crosses, measured in segregant population derived from contrasting parental regarding their resistance to cist nematode (race 3) - SCN and powdery mildew - PM. The analyses were made in F2 population through SSR (single sequence repeat) markers located in a 55CM region around Rmd (powdery mildew) and Rhg1 (cist nematode) resistance genes. After screening makers for their polymorphism, only polymorphic markers were used to detect crossovers. All markers were not significant by chi-square test (P > 0.05), showing that observed values corroborates to genotypic inheritance ratio expected in F2 population (1:2:1). Thus, the higher average of crossovers for some populations were observed for G4 (4.00), at linkage group G and J8 (2.91), at linkage group J. On the other hand, the higher average of crossovers considering the generation number to form each population, was found for G2 (2.02) and J8 (0.97). The recombination between alleles occurred in some populations, however, to G4 and J8, in 1.89% of the genotypes not showing crossover. In general, the crosses with larger numbers of parents showed higher number of crossovers, being very satisfactory for the creation of genetic variability. Soybean breeding progress has been accomplished in part by creating on new within_chromossome allele combinations.
Orientador: Antonio Orlando Di Mauro
Coorientador: Todd Pfeiffer
Banca: Natal Antonio Vello
Banca: Osvaldo Toshiyuki Hamawak
Banca: José Roberto Môro
Banca: Janete Apparecida Desidério Sena
Doutor
18
Brown, John. "Spatial Allocation, Imputation, and Sampling Methods for Timber Product Output Data." Diss., Virginia Tech, 2009. http://hdl.handle.net/10919/29147.
Анотація:
Data from the 2001 and 2003 timber product output (TPO) studies for Georgia were explored to determine new methods for handling missing data and finding suitable sampling estimators.
Mean roundwood volume receipts per mill for the year 2003 were calculated using the methods developed by Rubin (1987). Mean receipts per mill ranged from 4.4 to 14.2 million ft3. The mean value of 9.3 million ft3 did not statistically differ from the NONMISS, SINGLE1, and SINGLE2 references means (p=.68, .75, and .76 respectively).
Fourteen estimators were investigated to investigate sampling approaches, with estimators being of several means types (simple random sample, ratio, stratified sample, and combined ratio) as well as employing two methods for stratification (Dalenius-Hodges (DH) square root of the Frequency method and a cluster analysis method. Relative efficiency (RE) improved when the number of groups increased and when employing a ratio estimator, particularly a combined ratio. Neither the DH method nor the cluster analysis method performed better than the other.
Six bound sizes (1, 5, 10, 15, 20, and 25 percent) were considered for deriving samples sizes for the total volume of roundwood. The minimum achievable bound size was found to be 10 percent of the total receipts volume for the DH-method using a two group stratification. This was true for both the stratified and combined ratio estimators. In addition, for the stratified and combined ratio estimators, only the DH method stratifications were able to reach a 10 percent bound on the total (6 of the 12 stratified estimators). The remaining six stratified estimators were able to achieve a 20 percent bound of the total.
Finally, nonlinear repeated measures models were developed to spatially allocate mill receipts to surrounding counties in the event of obtaining only a mill's total receipt volume. A Gompertz model with a power spatial covariance was found to be the best performing when using road distances from the mills to either county center type (geographic or forest mass). These models utilized the cumulative frequency of mill receipts as the response variable, with cumulative frequencies based on distance from the mill to the county.Ph. D.
19
Gould, Robert A. "The use of multiple measures, repeated feedback, goal setting, shaping, and nutrition education to lower serum cholesterol levels in males." Thesis, Virginia Tech, 1989. http://hdl.handle.net/10919/45978.
Анотація:
Although the association between elevated serum cholesterol levels and cardiovascular risk has been known for many years, few studies, with freely living individuals have used a full complirnent of intervention strategies to attempt to alter practices associated with elevated serum cholesterol. Two studies, (Study 1, n=4; Study 2, n=8) with 12 middle age men (mean age = 47.3 years) and with elevated serum cholesterol (x= 238.7 mg/dl) are presented that use multiple measures of serum cholesterol (using the Boehringer Mannheim Reflotron and finger stick technique). The main intervention strategies included a combination of procedures using education, frequent serum cholesterol feedback (two to three times per week), and specific dietary feedback (one to two times per week). A less intensive intervention that is similar to recent studies in the literature was also implemented and assessed for half the subjects in Study The results of the two studies indicated that within approximately 14 weeks, the combination of enhanced procedures reduced serum cholesterol by about 14%, or about double that found in prior studies. The less intensive intervention showed reductions of 9.1% The use of multiple measures also allowed for the study of intraindividual variability. issues pertaining to maintenance of effect, cost-effectiveness, and generalizability are also discussed.
Master of Science
20
Padlubnaya, Diana B. "Effects of dizocilpine, chlordiazepoxide, and scopolamine alone and in combination on a multiple-component, repeated-acquisition test of spatial learning /." Electronic version (PDF), 2003. http://dl.uncw.edu/etd/2003/padlubnayad/dianapadlubnaya.html.
21
Shah, Nikhil N. "SH3 AND MULTIPLE ANKYRIN REPEAT DOMAIN 3 (SHANK3) AFFECTS THE EXPRESSION OF HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED (HCN) CHANNELS IN MOUSE MODELS OF AUTISM." VCU Scholars Compass, 2017. http://scholarscompass.vcu.edu/etd/4997.
Анотація:
SH3 and multiple ankyrin repeat domains 3 (SHANK3) is a multidomain scaffold protein that is highly augmented in the postsynaptic density (PSD) of excitatory glutamatergic synapses within the central and peripheral nervous systems. SHANK3 links neurotransmitter receptors, ion channels, and other critical membrane proteins to intracellular cytoskeleton and signal transduction pathways. Mutations in SHANK3 are linked with a number neuropsychiatric disorders including autism spectrum disorders (ASDs). Intellectual disability, impaired memory and learning, and epilepsy are some of the deficits commonly associated with ASDs that result from mutations in SHANK3. Interestingly, these symptoms show some clinical overlap with presentations of human neurological disorders involving hyperpolarization-activated cyclin nucleotide-gated (HCN) channels. In fact, it has recently been demonstrated in human neurons that SHANK3 haploinsufficiency causes Ih-channel dysfunction, and that SHANK3 has a physical interaction with HCN channels via its ANKYRIN repeat domain. These insights suggest that SHANK3 may play important roles in HCN channel expression and function, and put forward the idea that HCN channelopathies may actually encourage some of the symptoms observed in patients with SHANK-deficiency related ASDs. In this study, we provide preliminary data that suggests the ANK domain of SHANK3 interacts with COOH portion of HCN1. We also exploited the differences between two mouse models of autism to show that a subset of SHANK3 isoforms may be involved in the proper expression and function of HCN channels. We found that HCN2 expression is significantly decreased in a mouse model lacking all major isoforms of SHANK3 (exons 13-16 deleted; Δ13-16), while HCN2 expression is unaltered in a mouse model only lacking SHANK3a and SHANK3b (exons 4-9 deleted; Δ4-9). Surprisingly, we also found that HCN4 expression is altered in SHANK3Δ13-16, but not SHANK3Δ4-9. Taken together, our results show HCN channelopathy as a major downstream carrier of SHANK3 deficiency.
22
Muniz, Franco Romero Silva [UNESP]. "Análise de variabilidade genética em populações segregantes de soja." Universidade Estadual Paulista (UNESP), 2007. http://hdl.handle.net/11449/102817.
Анотація:
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A variabilidade entre progênies é criada pela segregação cromossômica independente dos genes e pela recombinação genética intracromossomal durante a meiose. O objetivo deste estudo foi analisar a variabilidade derivada de crossing-overs em cruzamentos biparentais (G2 e J2), quádruplos (G4 e J4) e óctuplos (G8 e J8), avaliados em populações segregantes derivadas de parentais contrastantes para resistência ao nematóide de cisto da soja (raça 3) – NCS – e ao oídio - O. A análise foi realizada em populações F2, através de marcadores SSR (single sequence repeat) concentrados em uma região de 55 cM ao redor do gene rmd (resistência ao oídio) e rhg1 (resistência ao NCS). Após o teste dos marcadores, quanto ao polimorfismo, apenas marcadores polimórficos foram utilizados para detectar crossing-over. Todos os marcadores analisados foram não significativos pelo teste de qui-quadrado (P > 0,05), indicando que os valores observados se ajustam à proporção genotípica esperada em F2 (1:2:1). As maiores médias de crossing-over por genótipo foram obtidas para G4 (4,00), no grupo G, e J8 (2,91), no grupo J. Por outro lado, as maiores médias de crossing-over considerando o número de gerações para formar cada população, foram para G2 (2,02) e J8 (0,97). A recombinação entre alelos ocorreu em algumas populações, entretanto para G4 e J8 em 1,89% dos genótipos não ocorreram. Em geral, nos cruzamentos com maior número de parentais envolvidos a ocorrência de crossingover foi maior, sendo satisfatórios na criação de variabilidade. O progresso no melhoramento de soja tem sido alcançado em partes pela criação de novas combinações alélicas dentro dos cromossomos.
The variability among the progenies is created by chromosome segregation, independent assortment of genes, and intra-chromosomal genetic recombination during meiosis. The objective of this study was to analyze the variability derived from crossovers in soybean biparental (G2 and J2), quadruple (G4 and J4) and octuple (G8 and J8) crosses, measured in segregant population derived from contrasting parental regarding their resistance to cist nematode (race 3) – SCN and powdery mildew – PM. The analyses were made in F2 population through SSR (single sequence repeat) markers located in a 55CM region around Rmd (powdery mildew) and Rhg1 (cist nematode) resistance genes. After screening makers for their polymorphism, only polymorphic markers were used to detect crossovers. All markers were not significant by chi-square test (P > 0.05), showing that observed values corroborates to genotypic inheritance ratio expected in F2 population (1:2:1). Thus, the higher average of crossovers for some populations were observed for G4 (4.00), at linkage group G and J8 (2.91), at linkage group J. On the other hand, the higher average of crossovers considering the generation number to form each population, was found for G2 (2.02) and J8 (0.97). The recombination between alleles occurred in some populations, however, to G4 and J8, in 1.89% of the genotypes not showing crossover. In general, the crosses with larger numbers of parents showed higher number of crossovers, being very satisfactory for the creation of genetic variability. Soybean breeding progress has been accomplished in part by creating on new within_chromossome allele combinations.
23
Kaba, James, and Barbara Connolly. "Overview of the Telemetry Network System (TMNS) RF Data Link Layer." International Foundation for Telemetering, 2012. http://hdl.handle.net/10150/581604.
Анотація:
ITC/USA 2012 Conference Proceedings / The Forty-Eighth Annual International Telemetering Conference and Technical Exhibition / October 22-25, 2012 / Town and Country Resort & Convention Center, San Diego, CaliforniaAs the integrated Network Enhanced Telemetry (iNET) program prepares for developmental flights tests, refinements are being made to the Radio Access Network Standard that ensures interoperability of networked radio components. One key aspect of this interoperability is the definition of Telemetry Network System (TmNS) RF Data Link Layer functionality for conducting efficient communications between radios in a TDMA (Time Division Multiple Access) channel sharing scheme. This paper examines the overall structure of the TmNS RF Data Link Layer and provides an overview of its operation. Specific topics include Medium Access Control (MAC) scheduling and framing in the context of a burst-oriented TDMA structure, link layer encryption, the priority-enabled Automatic Repeat reQuest (ARQ) protocol, high-level network packet and link control message encapsulation, payload segmentation and reassembly, and radio Link Layer Control Messaging.
24
Cerasale, Mark. "The Effects of Computer-Assisted Repeated Readings on the Reading Performance of Middle School Students with Mild Intellectual Disabilities." Doctoral diss., University of Central Florida, 2009. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/3689.
Анотація:
The No Child Left Behind Act of 2001 has mandated that all public school students will be reading at grade level by the 2013-2014 school year. Florida has embarked on an agenda to ensure that the kindergarten through high school student population is reading at or above grade level by 2014. Many of Florida's low-performing student population, including middle school students with high incidence disabilities, are reading below grade level. Using a multiple baseline across subjects design, this study examined the impact of computer-assisted repeated readings on the reading performance of three middle school students with mild intellectual disabilities over the course of 67 days. Results showed an improvement in reading fluency rate using instructional level text. The study was evaluated using quality indicators of single-subject research in special education. Future research is advocated to replicate this study across different grades and exceptionalities.Ed.D.
Department of Child, Family and Community Sciences
Education
Curriculum and Instruction EdD
25
Chen, Lei. "Uncovering Differential Symptom Courses with Multiple Repeated Outcome Measures: Interplay between Negative and Positive Symptom Trajectories in the Treatment of Schizophrenia." University of Cincinnati / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1342729413.
26
Cloete, Kevin Wesley. "Development of Y-STR genotyping systems suitable for sexual assault cases in South Africa." Thesis, University of the Western Cape, 2010. http://etd.uwc.ac.za/usrfiles/modules/etd/docs/etd_gen8Srv25Nme4_4315_1274816776.pdf.
27
Nam, Young-Han. "On Throughput-Reliability-Delay Tradeoffs in Wireless Networks." The Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=osu1204680962.
28
Seh-Jin, CHANG. "A Generalization of the Revelation Principle in an Informationally Decentralized Economy." 名古屋大学大学院経済学研究科附属国際経済政策研究センター, 2009. http://hdl.handle.net/2237/14043.
29
Zajac, Pawel. "Parallel target selection by trinucleotide threading." Doctoral thesis, KTH, Genteknologi, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-11284.
Анотація:
DNA is the code for all life. Via intermediary RNA the information encoded by the genome is relayed to proteins executing the various functions in a cell. Together, this repertoire of inherently linked biological macromolecules determines all characteristics and features of a cell. Technological advancements during the last decades have enabled the pursuit of novel types of studies and the investigation of the cell and its constituents at a progressively higher level of detail. This has shed light on numerous cellular processes and on the underpinnings of several diseases. For the majority of studies focusing on nucleic acids, an amplification step has to be implemented before an analysis, scoring or interrogation method translates the amplified material into relevant biological information. This information can, for instance, be the genotype of particular SNPs or STRs, or the abundance level of a set of interesting transcripts. As such, amplification plays a significant role in nucleic acid assays. Over the years, a number of techniques – most notably PCR – has been devised to meet this amplification need, specifically or randomly multiplying desired regions. However, many of the approaches do not scale up easily rendering comprehensive studies cumbersome, time-consuming and necessitating large quantities of material.Trinucleotide threading (TnT) – forming the red thread throughout this thesis – is a multiplex amplification method, enabling simultaneous targeted amplification of several nucleic acid regions in a specific manner. TnT begins with a controlled linear DNA thread formation, each type of thread corresponding to a segment of interest, by a gap-fill reaction using a restricted trinucleotide set. The whole collection of created threads is subsequently subjected to an exponential PCR amplification employing a single primer pair. The generated material can thereafter be analyzed with a multitude of readout and detection platforms depending on the issue or characteristic under consideration.TnT offers a high level of specificity by harnessing the inherent specificities of a polymerase and a ligase acting on a nucleotide set encompassing three out of the four nucleotide types. Accordingly, several erroneous events have to occur in order to produce artifacts. This necessitates override of a number of control points.The studies constituting this thesis demonstrate integration of the TnT amplification strategy in assays for analysis of various aspects of DNA and RNA. TnT was adapted for expression profiling of intermediately-sized gene sets using both conventional DNA microarrays and massively parallel second generation 454 sequencing for readout. TnT, in conjunction with 454 sequencing, was also employed for allelotyping, defined as determination of allele frequencies in a cohort. In this study, 147 SNPs were simultaneously assayed in a pool comprising genomic DNA of 462 individuals. Finally, TnT was recruited for parallel amplification of STR loci with detection relying on capillary gel electrophoresis. In all investigations, the material generated with TnT was of sufficient quality and quantity to produce reliable and accurate biological information.Taken together, TnT represents a viable multiplex amplification technique permitting parallel amplification of genomic segments, for instance harboring polymorphisms, or of expressed genes. In addition to these, this versatile amplification module can be implemented in assays targeting a range of other features of genomes and transcriptomes.QC 20100819
30
Feuerschuette, Otto Henrique May. "Diversidade genética e características fenotípicas do estreptococo do grupo B do trato anogenital de gestantes." reponame:Repositório Institucional da UNISUL, 2018. http://www.riuni.unisul.br/handle/12345/4823.
Анотація:
Introduction: Colonization of the anogenital tract of pregnant women by Group B Streptococcus (GBS) is the main risk factor for early-onset neonatal sepsis. Identification of maternal colonization allows antimicrobial prophylaxis and prevention of vertical transmission. Objectives: To identify the genetic diversity and phenotypic characteristics of GBS using molecular biology techniques and culture in specific medium, and the epidemiological aspects of pregnant women colonized by this bacterium. Methods: It was performed a cross-sectional study, anogenital samples of 316 pregnant women were collected between 35 and 37 weeks and submited to culture in specific medium, antimicrobial susceptibility test, multiplex PCR, multi locus sequence typing (MLST) and multi locus variable number of tandem repeat analysis (MLVA). The epidemiological aspects of colonized and non-colonized pregnant women were also investigated. Results: It was obtained a prevalence of 36.4% by culture and 38.6% by PCR. Multiplex PCR had sensitivity of 100%, specificity of 96.5%, positive predictive value of 94.3% and negative predictive value of 100%. The most common serotypes were Ia, V, II and III. Resistance genes were identified in 34 samples. Sensitivity to penicillin was universal, 24.3% presented resistance to erythromycin and 14.8% to clindamycin. Evaluating the epidemiological variables, there were no differences between the colonized and non-colonized pregnant women. Diversity index and number of genotypes found by MLST was 0.608 and 6, and by MLVA was 0.840 and 15, respectively. Conclusion: We found a high prevalence of maternal GBS colonization, with serotype distribution similar to the Americas region. Multiplex PCR was more accurate than culture, and maternal epidemiological variables showed no difference when evaluating presence or absence of bacterial colonization, its serotypes and antimicrobial resistance. MLVA showed a higher discrimination capacity among the unrelated strains than MLST.Submitted by Otto Henrique May Feuerschuette (otto.feurschuette@unisul.br) on 2018-04-26T00:54:22Z No. of bitstreams: 2 license_rdf: 811 bytes, checksum: e39d27027a6cc9cb039ad269a5db8e34 (MD5) OTTO TESE CORRIGIDA PÓS BANCA (1).pdf FINAL.pdf: 3081595 bytes, checksum: afad5beba2687558aafe2f1705d36e01 (MD5)
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Introdução: A colonização do trato anogenital de gestantes pelo Estreptococo do grupo B (EGB) é o fator de risco primário para a sepse neonatal precoce. A identificação da colonização materna permite a profilaxia antimicrobiana e prevenção da transmissão vertical. Objetivos: Identificar a diversidade genética e as características fenotípicas do EGB utilizando-se técnicas de biologia molecular e cultura em meio específico, e avaliar os aspectos epidemiológicos de gestantes colonizadas por essa bactéria Métodos: Foi realizado um estudo transversal com 316 amostras anogenitais de gestantes entre 35 e 37 semanas para realização de cultura em meio específico, teste de sensibilidade aos antimicrobianos, PCR multiplex, multi locus sequence typing (MLST) e multi locus variable number of tandem repeat analysis (MLVA). Pesquisou-se também os aspectos epidemiológicos dessas gestantes. Resultados: Foi encontrada prevalência de 36,4% pela cultura e 38,6% pela PCR. A PCR multiplex apresentou sensibilidade de 100%, especificidade de 96,5%, valor preditivo positivo de 94,3% e valor preditivo negativo de 100%. Os sorotipos mais encontrados foram Ia, V, II e III. Os genes de resistência foram identificados em 34 amostras. A sensibilidade à penicilina foi universal, 24,3% apresentaram resistência à eritromicina e 14,8% à clindamicina. Avaliando-se as variáveis epidemiológicas, não se identificaram diferenças entre as gestantes colonizadas e não colonizadas. O índice de diversidade e o número de genogrupos encontrados pelo MLST foi 0,608 e 6, e pela MLVA foi 0,840 e 15, respectivamente Conclusão: Constatou-se uma alta prevalência de colonização materna, com distribuição dos sorotipos semelhante à região das Américas. A PCR multiplex foi mais acurada que a cultura, e as variáveis epidemiológicas maternas não apresentaram diferença significativa ao avaliar-se a presença ou não de colonização bacteriana, seus sorotipos e a resistência aos antimicrobianos. A MLVA apresentou uma capacidade de discriminação entre as cepas não relacionadas maior do que a MLST
31
Azarian, Yazdi Kambiz. "Outage limited cooperative channels protocols and analysis /." Columbus, Ohio : Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1154740723.
32
Siemer, Alexander. "Die statistische Auswertung von ordinalen Daten bei zwei Zeitpunkten und zwei Stichproben." Doctoral thesis, [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=964606062.
33
Winkler, Anderson M. "Widening the applicability of permutation inference." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:ce166876-0aa3-449e-8496-f28bf189960c.
Анотація:
This thesis is divided into three main parts. In the first, we discuss that, although permutation tests can provide exact control of false positives under the reasonable assumption of exchangeability, there are common examples in which global exchangeability does not hold, such as in experiments with repeated measurements or tests in which subjects are related to each other. To allow permutation inference in such cases, we propose an extension of the well known concept of exchangeability blocks, allowing these to be nested in a hierarchical, multi-level definition. This definition allows permutations that retain the original joint distribution unaltered, thus preserving exchangeability. The null hypothesis is tested using only a subset of all otherwise possible permutations. We do not need to explicitly model the degree of dependence between observations; rather the use of such permutation scheme leaves any dependence intact. The strategy is compatible with heteroscedasticity and can be used with permutations, sign flippings, or both combined. In the second part, we exploit properties of test statistics to obtain accelerations irrespective of generic software or hardware improvements. We compare six different approaches using synthetic and real data, assessing the methods in terms of their error rates, power, agreement with a reference result, and the risk of taking a different decision regarding the rejection of the null hypotheses (known as the resampling risk). In the third part, we investigate and compare the different methods for assessment of cortical volume and area from magnetic resonance images using surface-based methods. Using data from young adults born with very low birth weight and coetaneous controls, we show that instead of volume, the permutation-based non-parametric combination (NPC) of thickness and area is a more sensitive option for studying joint effects on these two quantities, giving equal weight to variation in both, and allowing a better characterisation of biological processes that can affect brain morphology.
34
Biral, Andrea. "Novel Network Paradigms: Microfluidic and M2M Communications." Doctoral thesis, Università degli studi di Padova, 2017. http://hdl.handle.net/11577/3424683.
Анотація:
The present thesis focuses on two appealing paradigms that are expected to characterize the next generation of communication systems: microfluidic networking and Machine to Machine (M2M) Communications. Concerning the former topic, we show how it is possible to introduce switching and routing mechanism in microfluidic systems. We define some simple mathematical models that capture the macroscopic behavior of droplets in microfluidic networks. Then, we use them to implement a simulator that is able to reproduce the motion and predict the path of droplets in a generic microfluidic system. We validate the simulator and apply it to design a network with bus topology. Finally, we prove the feasibility of attaining molecular communication in this domain by describing a simple protocol that exploits droplets length/interdistance modulation to send information.
The research activity on M2M, instead, is aimed at the investigation of two critical issues that are expected to affect Machine-Type Communication (MTC), i.e. energy efficiency and massive access. Regarding energy efficiency, we address the problem of delivering a fixed data payload over a Rayleigh fading wireless channel with the purpose of minimizing the average total energy cost, given by the sum of the transmit energy and an overhead circuit energy, to complete it. This scenario is well suited for uplink cellular MTC in future 5G Internet of Things (IoT) use cases, where the focus is more on device energy efficiency than on throughput. We describe the optimal transmission policies to be used under various coordinated access scenarios with different levels of channel state information and transmitter/receiver capabilities, and show the corresponding theoretical bounds. In the last part of the work, we study the asymptotic performance of uncoordinated access schemes with Multi Packet Reception (MPR) and Successive Interference Cancellation (SIC) techniques for contention resolution at the receiver. The corresponding results in terms of throughput in a massive access M2M scenario are finally evaluated and discussed.La presente tesi si focalizza sullo studio di due importanti paradigmi che si prevede possano caratterizzare i sistemi di comunicazione di prossima generazione: le reti microfluidiche e le comunicazioni Machine to Machine (M2M). Riguardo alle reti microfluidiche, in questo lavoro illustriamo come sia possibile introdurre elementi di switch e meccanismi di routing all’interno di sistemi microfluidici. Definiamo poi alcuni semplici modelli matematici che descrivono il comportamento macroscopico di gocce all’interno di tali reti. Questi ultimi sono quindi sfruttati per implementare un simulatore che è capace di riprodurre il movimento e predire il percorso delle gocce in un generico sistema microfluidico. Dopo averlo validato sperimentalmente, il simulatore è impiegato per progettare una rete microfluidica con topologia a bus. Infine, viene dimostrato come sia possibile realizzare comunicazioni molecolari in questo ambito tramite la formalizzazione e la descrizione di un protocollo che sfrutta la modulazione della lunghezza/interdistanza delle gocce per trasferire informazione. L’attività di ricerca in merito alle comunicazioni M2M, invece, è finalizzata allo studio di due importanti criticità insite nelle Machine-Type Communications (MTCs), ovvero l’efficienza energetica e l’accesso simultaneo di massa (massive access). Per quanto concerne l’efficienza energetica, viene affrontato il problema di trasmettere un payload di una certa lunghezza fissata attraverso un canale wireless affetto da Rayleigh fading con lo scopo di minimizzare il costo totale medio dell’utente finale, dato dalla somma dell’energia di trasmissione e di quella di circuito, per completare l’operazione. Tale scenario ben si applica al contesto di trasmissioni cellulari per applicazioni di tipo IoT nelle future reti 5G, dove l’attenzione è rivolta maggiormente all’efficienza energetica dei dispositivi rispetto al throughput, in quanto le UE hanno tipicamente capacità computazionali ed energetiche esigue e si limitano ad inviare sporadicamente pacchetti molto brevi. Vengono quindi descritte le strategie ottime di trasmissione da adottare in un contesto di accesso coordinato a seconda del livello di dettaglio sulle informazioni di canale e delle potenzialità di trasmettitore/ricevitore, illustrando i corrispondenti limiti teorici. Nell’ultima parte del lavoro vengono studiate le prestazioni asintotiche di schemi di accesso non coordinati quando si utilizzano tecniche di Multi Packet Reception (MPR) e Successive Interference Cancellation (SIC) per la risoluzione delle collisioni al ricevitore. I risultati corrispondenti, in termini di throughput, per uno scenario M2M con massive access sono infine ricavati e discussi.
35
Coppalle, Renaud. "Mise en lumière des capacités préservées d'apprentissage des personnes malades d'Alzheimer à un stade modéré à sévère à l'aide de l'art : un autre regard pour un autre accompagnement New long-term encoding in severely amnesic Alzheimer’s disease patients revealed through repeated exposureto artistic items Does multiple format presentation of songs increase encoding in patients with Alzheimer’s disease at a moderate to late stage? Preserved familiarity-based recognition for music and paintings in patients with Alzheimer’s disease at a moderate to late stage with extensive damages to the medial temporal lobe L’accompagnement des aidants depersonnes atteintes de maladies d’Alzheimerou apparentées : renouveler les approchesthéoriques de l’accompagnement en France Suivi de la situation et des ressentis des proches aidants de personnes avec maladie d’Alzheimer et troubles apparentés: Le cas particulier du confinement lié au Covid 19 Apports respectifs de la clinique et de la rechercheà la neuropsychologie Preservation of musical memory throughout the progression of Alzheimer’s disease? Toward a reconciliation of theoretical, clinical, and neuroimaging evidence Do musicians have better mnemonicand executive performance than actors? Influence of regular musical or theater practice in adults and in the elderly." Thesis, Normandie, 2020. http://www.theses.fr/2020NORMC018.
Анотація:
La maladie d’Alzheimer (MA) est considérée depuis plus de 30 ans comme une pathologie de la mémoire empêchant l’apprentissage d’informations nouvelles en mémoire déclarative. Cependant, l’Histoire de la neuropsychologie rapporte des cas de patients présentant des capacités d’encodage résiduelles malgré une amnésie non-dégénérative avec des lésions pourtant proches de celles de la MA. Si les tâches de laboratoire échouent à montrer ces capacités dans la MA dès les stades légers en utilisant des stimuli verbaux et picturaux neutres, nous avons étudié dans quelle mesure la musique et d’autres types de stimuli artistiques peuvent permettre de les révéler dans des conditions plus écologiques, notamment par l’exposition passive répétée. En utilisant une échelle d’apprentissage construite pour étudier l’évolution du sentiment de familiarité dans la MA, nous avons pu révéler et décrire des apprentissages nouveaux chez ces patients à des stades modérés à sévères, ainsi qu’en inférer la nature au regard des modèles de mémoire classiques et contemporains. Pour finir, nous proposons de discuter en quoi la prise en compte de ces capacités pourrait changer les représentations associées à la MA, et améliorer l’accompagnement proposé aux patients et à leurs aidants familiaux et professionnelsFor the past 30 years, Alzheimer’s disease (AD) has been considered as a crippling memory disorder impairing any possibility of new learnings in declarative memory. However, in the history of neuropsychology, cases of residual encoding have been reported with amnestic patients presenting different etiologies despite showing lesions very similar to AD. Although using neutral verbal and pictural items in laboratory settings failed to report preserved learning capacities from the mild stages, we investigated how using music and other artistic items in ecological settings may reveal these capacities in AD patients at a moderate to late stage, notably by passive repeated exposition. By relying on a behavioral scale designed to study the evolution of the sense of familiarity in these patients, we were able to show and describe new learnings in this population, and inferring their nature in view of both classical and contemporary memory models. Finally, we offer suggestions to discuss how acknowledging these capacities could change the way AD is perceived, and how it could help caring for people affected by it and their familial and professional caregivers
36
"Detecting short adjacent repeats in multiple sequences: a Bayesian approach." 2010. http://library.cuhk.edu.hk/record=b5894412.
Анотація:
Li, Qiwei.Thesis (M.Phil.)--Chinese University of Hong Kong, 2010.
Includes bibliographical references (p. 75-85).
Abstracts in English and Chinese.
Abstract --- p.i
Acknowledgement --- p.iv
Chapter 1 --- Introduction --- p.1
Chapter 1.1 --- Repetitive DNA Sequence --- p.3
Chapter 1.1.1 --- Definition and Categorization of Repeti- tive DNA Sequence --- p.3
Chapter 1.1.2 --- Definition and Categorization of Tandem Repeats --- p.4
Chapter 1.1.3 --- Definition and Categorization of Interspersed Repeats --- p.6
Chapter 1.2 --- Research Significance --- p.7
Chapter 1.3 --- Contributions --- p.9
Chapter 1.4 --- Thesis Organization --- p.11
Chapter 2 --- Literature Review and Overview of Our Method --- p.13
Chapter 2.1 --- Existing Methods --- p.14
Chapter 2.2 --- Overview of Our Method --- p.17
Chapter 3 --- Theoretical Background --- p.22
Chapter 3.1 --- Multinomial Distributions --- p.23
Chapter 3.2 --- Dirichlet Distribution --- p.23
Chapter 3.3 --- Metropolis-Hastings Sampling --- p.25
Chapter 3.4 --- Gibbs Sampling --- p.26
Chapter 4 --- Problem Description --- p.28
Chapter 4.1 --- Generative Model --- p.29
Chapter 4.1.1 --- Input Data R --- p.31
Chapter 4.1.2 --- Parameters A (Repeat Segment Starting Positions) --- p.32
Chapter 4.1.3 --- Parameters S (Repeat Segment Structures) --- p.33
Chapter 4.1.4 --- Parameters θ(Motif Matrix) --- p.35
Chapter 4.1.5 --- Parameters Φ (Background Distribution) . --- p.36
Chapter 4.1.6 --- An Example of the Model Schematic Di- agram --- p.37
Chapter 4.2 --- Parameter Structure --- p.38
Chapter 4.3 --- Posterior Distribution --- p.40
Chapter 4.3.1 --- The Full Posterior Distribution --- p.41
Chapter 4.3.2 --- The Collapsed Posterior Distribution --- p.42
Chapter 4.4 --- Conclusion --- p.43
Chapter 5 --- Methodology --- p.45
Chapter 5.1 --- Schematic Procedure --- p.46
Chapter 5.1.1 --- The Basic Schematic Procedure --- p.46
Chapter 5.1.2 --- The Improved Schematic Procedure --- p.47
Chapter 5.2 --- Initialization --- p.49
Chapter 5.3 --- Predictive Update Step for θn and Φn --- p.50
Chapter 5.4 --- Gibbs Sampling Step for an --- p.50
Chapter 5.5 --- Metropolis-Hastings Sampling Step for sn --- p.51
Chapter 5.5.1 --- Rear Indel Move --- p.53
Chapter 5.5.2 --- Partial Shift Move --- p.56
Chapter 5.5.3 --- Front Indel Move --- p.56
Chapter 5.6 --- Phase Shifts --- p.57
Chapter 5.7 --- Conclusion --- p.58
Chapter 6 --- Results and Discussion --- p.60
Chapter 6.1 --- Settings --- p.61
Chapter 6.2 --- Experiment on Synthetic Data --- p.63
Chapter 6.3 --- Experiment on Real Data --- p.69
Chapter 7 --- Conclusion and Future Work --- p.72
Chapter 7.1 --- Conclusion --- p.72
Chapter 7.2 --- Future Work --- p.74
Bibliography --- p.75
37
Leap, Katie. "Multiple Testing Correction with Repeated Correlated Outcomes: Applications to Epigenetics." 2017. https://scholarworks.umass.edu/masters_theses_2/559.
Анотація:
Epigenetic changes (specifically DNA methylation) have been associated with adverse health outcomes; however, unlike genetic markers that are fixed over the lifetime of an individual, methylation can change. Given that there are a large number of methylation sites, measuring them repeatedly introduces multiple testing problems beyond those that exist in a static genetic context. Using simulations of epigenetic data, we considered different methods of controlling the false discovery rate. We considered several underlying associations between an exposure and methylation over time.
We found that testing each site with a linear mixed effects model and then controlling the false discovery rate (FDR) had the highest positive predictive value (PPV), a low number of false positives, and was able to differentiate between differential methylation that was present at only one time point vs. a persistent relationship. In contrast, methods that controlled FDR at a single time point and ad hoc methods tended to have lower PPV, more false positives, and/or were unable to differentiate these conditions.
Validation in data obtained from Project Viva found a difference between fitting longitudinal models only to sites significant at one time point and fitting all sites longitudinally.
38
侯志賢. "Performance of Selective Repeat ARQ Protocols on Burst Error Channel for Multiple Connections." Thesis, 2000. http://ndltd.ncl.edu.tw/handle/03798984581809263840.
39
Smith, Alexander. "Design strategies for repeated MRI scanning in multiple sclerosis clinical trials." Thesis, 1999. http://hdl.handle.net/2429/9769.
Анотація:
A rising trend in multiple sclerosis (MS) clinical trials is the inclusion of a cohort
study in which patients undergo repeated magnetic resonance imaging (MRI) scanning,
most commonly at monthly intervals. Outcome measures for these cohorts are based on
newly active lesions which are detected on the brain stem, and which are now commonly
believed to be highly associated with MS exacerbations. These cohorts have the benefit
of allowing researchers to see a clear treatment effect in a relatively shorter amount of
time than with the more common clinical outcomes. Employing two large data sets, we
attempt to address two distinct research topics relating to designs for such trials.
The first topic is related to a published algorithm that uses placebo data to repeatedly
simulate trials for a given efficacy as a means of producing sample size calculations.
We present a validation of this algorithm, and propose a theoretical alternative to the
recommended simulation. The second topic involves the question of optimal designs for
repeated MRI trials in MS where the analysis will be based on summary statistics for
the individual patients. Typically, designs have included one baseline scan, followed by
several scans while under treatment. We develop a model for such data and an approach
to examine optimality to recommend improvements to the most common choices for both
the method of analysis and the design, such as the use of an ANCOVA model for the response,
and the inclusion of multiple baselines as opposed to abundant treatment period
scans.
40
Meier, Maria. "Entwicklung und Validierung eines Short Tandem Repeat Multiplex Systems für die Typisierung degradierter DNA-Proben /." 2008. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=017376102&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.
41
Chiang, Inchi, and 蔣茵其. "Mining Cyclically Repeated Patterns with Multiple Minimum Supports: a Prefix-projected Based Approach." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/25815233076094533010.
Анотація:
碩士國立中正大學
資訊管理學系暨研究所
99
In business applications, there have been tremendous interests in analyzing customers’ repeated purchase behavior. Recently, the concepts of periodic pattern and cyclic pattern are used to discover recurring patterns from customer sequence database. Toroslu (2003) proposed cyclic pattern mining, which considers a new parameter, named repetition support, into the mining process. In a customer sequence, the occurrence of a subsequence must satisfy single user-specified repetition minimum support. In real-life applications, however, different items may have different frequencies in the database. If all items are set to have the same minimum repetition support, it may cause rare item problem. To solve this problem, we include the concept of multiple minimum supports (MMS) to allow users to specify multiple minimum item repetition support (MIR) according to the natures of items. In this paper, we first redefine cyclic sequential patterns based on MIR and original form of customer minimum support. A new algorithm, rep-PrefixSpan, is developed to discover complete set of cyclic sequential patterns from sequence database. The experimental result shows that the proposed approach achieves more preferable findings than conventional cyclic pattern mining.
42
Ke, Yi-Feng, and 柯依鳳. ""Specific Medical Information Query System of the Insured" on the effect of repeat sedative hypnotic drugs to multiple hospitals." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/xxhvpd.
43
Gao, Wei. "Sequence Kernel Association Test, gene-environment interaction test, and meta-analysis for family samples with repeated measurements or multiple traits." Thesis, 2015. https://hdl.handle.net/2144/15688.
Анотація:
Genetic loci identified by single variant association tests account for only a small proportion of the heritability for most complex traits and diseases. Part of the unexplained heritability may be due to rare variants and their interactions with environmental factors. Different strategies have been taken to increase the power to detect genetic associations, such as increasing the sample size by including related participants and meta-analyzing multiple studies. Longitudinal data or repeated measurements are often available in prospective cohort studies. For complex diseases, multiple traits are usually collected to characterize affected individuals. Many of the existing statistical methods can only be applied to the scenarios when each participant has one measurement of a single trait. To take full advantage of the data and further improve power, multiple measurements per individual may be included in the analysis when available. In this dissertation we develop statistical methods for rare variant association testing and gene by environment interaction analysis, and discuss gene-based meta-analysis for studies with different designs. First, we propose the generalized Sequence Kernel Association Test (genSKAT) to deal with rare variants, familial correlation, and repeated measurements or multiple traits. This is an extension of the original SKAT and family-based SKAT that accounts for correlation between multiple measurements within each individual. In the second part of this dissertation, we discuss methods to test for the presence of gene-environment interaction effects in the genSKAT framework. Finally, we evaluate genSKAT meta-analysis methods to combine different types of studies: samples of unrelated individuals with one observation per person or with multiple observations per person, and family samples with one observation per person or with multiple observations per person. Combining all these projects together, we contribute methodologies to detect rare variant associations by taking advantage of additional information, improve the chance to detect novel rare variant associations, and help in understanding the role that genetic factors play in various diseases and traits.
44
Rumore, Jillian. "Application and interpretation of multiple locus variable number tandem repeat analysis for Escherichia coli O157:H7 laboratory surveillance and outbreak response in Canada, 2008-2012." 2014. http://hdl.handle.net/1993/23863.
Анотація:
To enhance outbreak investigations of Shiga toxin-producing Escherichia coli O157:H7, PulseNet Canada has recently applied Multiple Locus Variable Number Tandem Repeat Analysis (MLVA) as a supplemental subtyping tool in combination with the gold standard subtyping method Pulsed-field Gel Electrophoresis (PFGE) for enhanced resolution of isolates exhibiting indistinguishable/highly similar PFGE patterns. The objective was to assess the discriminatory power and level of specificity MLVA offers for outbreak detection and response. Results demonstrate that MLVA provides a statistically significant increase in discriminatory power for outbreak investigations (0.998) compared to PFGE alone (0.993). MLVA was able to provide additional resolution over PFGE analysis and generally agreed with PFGE when isolates were identical and epidemiologically linked. MLVA shows great promise as a molecular epidemiological tool to complement PFGE, as it improves case categorization during outbreak investigations, and the greatest benefits of MLVA may be realized during routine surveillance, when epidemiological information is not available.
45
Du, Qinghe. "Adaptive Resource Allocation for Statistical QoS Provisioning in Mobile Wireless Communications and Networks." Thesis, 2010. http://hdl.handle.net/1969.1/ETD-TAMU-2010-12-8884.
Анотація:
Due to the highly-varying wireless channels over time, frequency, and space
domains, statistical QoS provisioning, instead of deterministic QoS guarantees, has
become a recognized feature in the next-generation wireless networks. In this dissertation,
we study the adaptive wireless resource allocation problems for statistical QoS
provisioning, such as guaranteeing the specified delay-bound violation probability,
upper-bounding the average loss-rate, optimizing the average goodput/throughput,
etc., in several typical types of mobile wireless networks.
In the first part of this dissertation, we study the statistical QoS provisioning for
mobile multicast through the adaptive resource allocations, where different multicast
receivers attempt to receive the common messages from a single base-station sender
over broadcast fading channels. Because of the heterogeneous fading across different
multicast receivers, both instantaneously and statistically, how to design the efficient
adaptive rate control and resource allocation for wireless multicast is a widely cited
open problem. We first study the time-sharing based goodput-optimization problem
for non-realtime multicast services. Then, to more comprehensively characterize the
QoS provisioning problems for mobile multicast with diverse QoS requirements, we
further integrate the statistical delay-QoS control techniques — effective capacity
theory, statistical loss-rate control, and information theory to propose a QoS-driven
optimization framework. Applying this framework and solving for the corresponding optimization problem, we identify the optimal tradeoff among statistical delay-QoS
requirements, sustainable traffic load, and the average loss rate through the adaptive
resource allocations and queue management. Furthermore, we study the adaptive
resource allocation problems for multi-layer video multicast to satisfy diverse statistical
delay and loss QoS requirements over different video layers. In addition,
we derive the efficient adaptive erasure-correction coding scheme for the packet-level
multicast, where the erasure-correction code is dynamically constructed based on multicast
receivers’ packet-loss statuses, to achieve high error-control efficiency in mobile
multicast networks.
In the second part of this dissertation, we design the adaptive resource allocation
schemes for QoS provisioning in unicast based wireless networks, with emphasis
on statistical delay-QoS guarantees. First, we develop the QoS-driven time-slot and
power allocation schemes for multi-user downlink transmissions (with independent
messages) in cellular networks to maximize the delay-QoS-constrained sum system
throughput. Second, we propose the delay-QoS-aware base-station selection schemes
in distributed multiple-input-multiple-output systems. Third, we study the queueaware
spectrum sensing in cognitive radio networks for statistical delay-QoS provisioning.
Analyses and simulations are presented to show the advantages of our proposed
schemes and the impact of delay-QoS requirements on adaptive resource allocations
in various environments.