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Готові списки джерел за темами / Multifunctional Inorganic Nanoparticles for Biomedical Diagnostics / Статті в журналах

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Статті в журналах з теми "Multifunctional Inorganic Nanoparticles for Biomedical Diagnostics"

Автор: Grafiati

Опубліковано: 11 березня 2023

Оновлено: 31 липня 2025

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1

Yanar, Fatih, Dario Carugo, and Xunli Zhang. "Hybrid Nanoplatforms Comprising Organic Nanocompartments Encapsulating Inorganic Nanoparticles for Enhanced Drug Delivery and Bioimaging Applications." Molecules 28, no. 15 (2023): 5694. http://dx.doi.org/10.3390/molecules28155694.

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Organic and inorganic nanoparticles (NPs) have attracted significant attention due to their unique physico-chemical properties, which have paved the way for their application in numerous fields including diagnostics and therapy. Recently, hybrid nanomaterials consisting of organic nanocompartments (e.g., liposomes, micelles, poly (lactic-co-glycolic acid) NPs, dendrimers, or chitosan NPs) encapsulating inorganic NPs (quantum dots, or NPs made of gold, silver, silica, or magnetic materials) have been researched for usage in vivo as drug-delivery or theranostic agents. These classes of hybrid mu

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2

Zmejkovski, Bojana B., Nebojša Đ. Pantelić, and Goran N. Kaluđerović. "Advanced Nanomaterials Functionalized with Metal Complexes for Cancer Therapy: From Drug Loading to Targeted Cellular Response." Pharmaceuticals 18, no. 7 (2025): 999. https://doi.org/10.3390/ph18070999.

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Developments of nanostructured materials have a significant impact in various areas, such as energy technology and biomedical use. Examples include solar cells, energy management, environmental control, bioprobes, tissue engineering, biological marking, cancer diagnosis, therapy, and drug delivery. Currently, researchers are designing multifunctional nanodrugs that combine in vivo imaging (using fluorescent nanomaterials) with targeted drug delivery, aiming to maximize therapeutic efficacy while minimizing toxicity. These fascinating nanoscale “magic bullets” should be available in the near fu

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3

Miranda, Margarida S., Ana F. Almeida, Manuela E. Gomes, and Márcia T. Rodrigues. "Magnetic Micellar Nanovehicles: Prospects of Multifunctional Hybrid Systems for Precision Theranostics." International Journal of Molecular Sciences 23, no. 19 (2022): 11793. http://dx.doi.org/10.3390/ijms231911793.

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Hybrid nanoarchitectures such as magnetic polymeric micelles (MPMs) are among the most promising nanotechnology-enabled materials for biomedical applications combining the benefits of polymeric micelles and magnetic nanoparticles within a single bioinstructive system. MPMs are formed by the self-assembly of polymer amphiphiles above the critical micelle concentration, generating a colloidal structure with a hydrophobic core and a hydrophilic shell incorporating magnetic particles (MNPs) in one of the segments. MPMs have been investigated most prominently as contrast agents for magnetic resonan

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4

Reichel, Victoria E., Jasmin Matuszak, Klaas Bente, et al. "Magnetite-Arginine Nanoparticles as a Multifunctional Biomedical Tool." Nanomaterials 10, no. 10 (2020): 2014. http://dx.doi.org/10.3390/nano10102014.

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Iron oxide nanoparticles are a promising platform for biomedical applications, both in terms of diagnostics and therapeutics. In addition, arginine-rich polypeptides are known to penetrate across cell membranes. Here, we thus introduce a system based on magnetite nanoparticles and the polypeptide poly-l-arginine (polyR-Fe3O4). We show that the hybrid nanoparticles exhibit a low cytotoxicity that is comparable to Resovist®, a commercially available drug. PolyR-Fe3O4 particles perform very well in diagnostic applications, such as magnetic particle imaging (1.7 and 1.35 higher signal respectively

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5

Wang, Hui, Jing Shen, Yingyu Li, et al. "Magnetic iron oxide–fluorescent carbon dots integrated nanoparticles for dual-modal imaging, near-infrared light-responsive drug carrier and photothermal therapy." Biomater. Sci. 2, no. 6 (2014): 915–23. http://dx.doi.org/10.1039/c3bm60297d.

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6

Ma, Dongling, and Ruiqi Yang. "(Invited) Multifunctional Nanohybrids for Biomedical Applications." ECS Meeting Abstracts MA2025-01, no. 60 (2025): 2901. https://doi.org/10.1149/ma2025-01602901mtgabs.

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Combination of different nanomaterials into a single architecture can lead to improved properties/performance or, even better, multifunctional nanoplatforms. In this talk, I will present some of our work on the rational design and realization of multifunctional nanohybrid materials for biomedical applications. Our research interest mainly consists in the combination of two functions: superparamagnetism and luminescence. A recent example is about a multifunctional NaGdF4:Nd3+@mSiO2 nanoplatform prepared by loading ultrasmall NaGdF4:Nd3+ nanoparticles into large-channel mesoporous SiO2 (mSiO2) n

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7

Orbay, Sinem, Ozgur Kocaturk, Rana Sanyal, and Amitav Sanyal. "Molecularly Imprinted Polymer-Coated Inorganic Nanoparticles: Fabrication and Biomedical Applications." Micromachines 13, no. 9 (2022): 1464. http://dx.doi.org/10.3390/mi13091464.

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Molecularly imprinted polymers (MIPs) continue to gain increasing attention as functional materials due to their unique characteristics such as higher stability, simple preparation, robustness, better binding capacity, and low cost. In particular, MIP-coated inorganic nanoparticles have emerged as a promising platform for various biomedical applications ranging from drug delivery to bioimaging. The integration of MIPs with inorganic nanomaterials such as silica (SiO2), iron oxide (Fe3O4), gold (Au), silver (Ag), and quantum dots (QDs) combines several attributes from both components to yield h

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8

Tran, Hung-Vu, Nhat M. Ngo, Riddhiman Medhi, et al. "Multifunctional Iron Oxide Magnetic Nanoparticles for Biomedical Applications: A Review." Materials 15, no. 2 (2022): 503. http://dx.doi.org/10.3390/ma15020503.

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Due to their good magnetic properties, excellent biocompatibility, and low price, magnetic iron oxide nanoparticles (IONPs) are the most commonly used magnetic nanomaterials and have been extensively explored in biomedical applications. Although magnetic IONPs can be used for a variety of applications in biomedicine, most practical applications require IONP-based platforms that can perform several tasks in parallel. Thus, appropriate engineering and integration of magnetic IONPs with different classes of organic and inorganic materials can produce multifunctional nanoplatforms that can perform

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9

Kumar, Hemant, Pramod Kumar, Vishal Singh, Shwetank Shashi Pandey, and Balaram Pani. "Synthesis and surface modification of biocompatible mesoporous silica nanoparticles (MSNs) and its biomedical applications: a review." Research Journal of Chemistry and Environment 27, no. 2 (2023): 135–46. http://dx.doi.org/10.25303/2702rjce1350146.

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This review gives a broad introduction to nanotechnology, mesoporous silica nanoparticles (MSNs) and synthesis techniques, along with their applications. Recent advances in morphological control and surface functionalization of MSNs have improved their biocompatibility and a strong emphasis on the physicochemical characteristics of MSNs, resulting in a step forward in traditional intervention techniques. This review highlights recent improvements in silica-assisted drug delivery systems including MSN-based sustained drug delivery systems and MSN-based controlled, targeted drug delivery systems

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10

Nakamura, Michihiro. "Biomedical applications of organosilica nanoparticles toward theranostics." Nanotechnology Reviews 1, no. 6 (2012): 469–91. http://dx.doi.org/10.1515/ntrev-2012-0005.

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AbstractNanoparticles for biomedical applications have several advantages as multifunctional agents. Among various types of nanoparticles for biomedical applications, silica nanoparticles have characteristic positioning due to their inherent property. The recent development of silica nanoparticles is creating a new trend in nanomedicine. A novel type of silica nanoparticle, organosilica nanoparticle, is both structurally and functionally different from the common (inorgano)silica nanoparticle. The organosilica nanoparticles are inherent organic-inorganic hybrid nanomaterials. The interior and

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11

Nirwan, Viraj P., Tomasz Kowalczyk, Julia Bar, Matej Buzgo, Eva Filová, and Amir Fahmi. "Advances in Electrospun Hybrid Nanofibers for Biomedical Applications." Nanomaterials 12, no. 11 (2022): 1829. http://dx.doi.org/10.3390/nano12111829.

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Electrospun hybrid nanofibers, based on functional agents immobilized in polymeric matrix, possess a unique combination of collective properties. These are beneficial for a wide range of applications, which include theranostics, filtration, catalysis, and tissue engineering, among others. The combination of functional agents in a nanofiber matrix offer accessibility to multifunctional nanocompartments with significantly improved mechanical, electrical, and chemical properties, along with better biocompatibility and biodegradability. This review summarizes recent work performed for the fabricat

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12

Vallabani, Naga Veera Srikanth, Sanjay Singh, and Ajay Singh Karakoti. "Magnetic Nanoparticles: Current Trends and Future Aspects in Diagnostics and Nanomedicine." Current Drug Metabolism 20, no. 6 (2019): 457–72. http://dx.doi.org/10.2174/1389200220666181122124458.

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Background: Biomedical applications of Magnetic Nanoparticles (MNPs) are creating a major impact on disease diagnosis and nanomedicine or a combined platform called theranostics. A significant progress has been made to engineer novel and hybrid MNPs for their multifunctional modalities such as imaging, biosensors, chemotherapeutic or photothermal and antimicrobial agents. MNPs are successfully applied in biomedical applications due to their unique and tunable properties such as superparamagnetism, stability, and biocompatibility. Approval of ferumoxytol (feraheme) for MRI and the fact that sev

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13

Zhang, Yuqian, Zerui Li, Ziqing Du, Jianming Pan, and Yanan Huang. "Multifunctional Upconversion Nanoparticles Transforming Photoacoustic Imaging: A Review." Nanomaterials 15, no. 14 (2025): 1074. https://doi.org/10.3390/nano15141074.

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Photoacoustic imaging (PAI) merges the high spatial resolution of optical methods with the deep tissue penetration provided by ultrasound, making it a valuable tool in biomedical imaging. In recent years, a diverse array of photoacoustic contrast agents, spanning both organic and inorganic materials, has been developed. Among them, upconversion nanoparticles (UCNPs) stand out as promising candidates due to their unique optical features, tunable absorption in the near-infrared I (NIR-I, 750–1350 nm) region, and strong potential for both imaging and treatment-related uses. This review discusses

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14

Walimbe, Ketaki G., Pranjali P. Dhawal, and Shruti A. Kakodkar. "Anticancer Potential of Biosynthesized Silver Nanoparticles: A Review." European Journal of Biology and Biotechnology 3, no. 2 (2022): 10–20. http://dx.doi.org/10.24018/ejbio.2022.3.2.338.

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The field of nanotechnology has emerged as a promising course of study branching out into various biomedical fields such as therapeutics, imaging, and diagnostics. Metallic nanoparticles, specifically silver, are an important area of study due to their multifunctionality and diverse morphological characteristics. Amongst the various methods of synthesis of these multifunctional nanoparticles such as physical methods and chemical, green synthesis is the most suitable method due to its eco-friendly nature, cost-effectiveness, and ease of production. This article summarizes the broad spectrum of

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15

Yang, Guang, Yue Lu, Hunter N. Bomba, and Zhen Gu. "Cysteine-rich Proteins for Drug Delivery and Diagnosis." Current Medicinal Chemistry 26, no. 8 (2019): 1377–88. http://dx.doi.org/10.2174/0929867324666170920163156.

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An emerging focus in nanomedicine is the exploration of multifunctional nanocomposite materials that integrate stimuli-responsive, therapeutic, and/or diagnostic functions. In this effort, cysteine-rich proteins have drawn considerable attention as a versatile platform due to their good biodegradability, biocompatibility, and ease of chemical modification. This review surveys cysteine-rich protein-based biomedical materials, including protein-metal nanohybrids, gold nanoparticle-protein agglomerates, protein-based nanoparticles, and hydrogels, with an emphasis on their preparation methods, esp

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16

Drozdov, Andrey S., Kristina S. Komarova, Elizaveta N. Mochalova, Elena N. Komedchikova, Victoria O. Shipunova, and Maxim P. Nikitin. "Fluorescent Magnetic Nanoparticles for Bioimaging through Biomimetic Surface Modification." International Journal of Molecular Sciences 24, no. 1 (2022): 134. http://dx.doi.org/10.3390/ijms24010134.

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Nanostructured materials and systems find various applications in biomedical fields. Hybrid organo–inorganic nanomaterials are intensively studied in a wide range of areas, from visualization to drug delivery or tissue engineering. One of the recent trends in material science is biomimetic approaches toward the synthesis or modification of functional nanosystems. Here, we describe an approach toward multifunctional nanomaterials through the biomimetic polymerization of dopamine derivatives. Magnetite nanoparticles were modified with a combination of dopamine conjugates to give multifunctional

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17

Li, Xiumei, Wanjia Xu, Yue Xin, et al. "Supramolecular Polymer Nanocomposites for Biomedical Applications." Polymers 13, no. 4 (2021): 513. http://dx.doi.org/10.3390/polym13040513.

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Polymer nanocomposites, a class of innovative materials formed by polymer matrixes and nanoscaled fillers (e.g., carbon-based nanomaterials, inorganic/semiconductor nanoparticles, metal/metal-oxide nanoparticles, polymeric nanostructures, etc.), display enhanced mechanical, optoelectrical, magnetic, catalytic, and bio-related characteristics, thereby finding a wide range of applications in the biomedical field. In particular, the concept of supramolecular chemistry has been introduced into polymer nanocomposites, which creates myriad “smart” biomedical materials with unique physicochemical pro

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18

Kausar, Ayesha. "Multifunctional Hybrids of Graphene Quantum Dots with Inorganic Nanoparticles (Metal, Metal Oxide and MOF) - Topical State and Evolutions." Trends in Sciences 22, no. 6 (2025): 9924. https://doi.org/10.48048/tis.2025.9924.

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Carbon based quantum dots have been discovered as unique florescent nanoentities having different types, such as carbon nanodots, graphene quantum dots, and polymer dots. Out of these, graphene quantum dots can be seen as zero dimensional derivatives of graphene (2 dimensional nanosheet). Due to recent advancement in the field of graphene quantum dots, various inorganic and organic hybrids have been reported in the literature so far. In this concern, inorganic nanoparticles like metal, metal oxide, as well as metal organic framework (MOF) have been used to design graphene quantum dots/metal na

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19

Rajeshkumar, S., J. Santhoshkumar, and Venkat Kumar Shamugam. "Synthesis of zinc oxide nanoparticles using plant leaf extract against urinary tract infection pathogen." Resource-Efficient Technologies, no. 4 (October 27, 2017): 459–65. http://dx.doi.org/10.18799/24056529/2017/4/172.

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In modern science, Nanotechnology is an ablaze field for the researchers. Zinc oxide nanoparticles (ZnO NPs) are known to be one of the most multifunctional inorganic nanoparticles with its application in treatment of urinary tract infection. Nanoparticles were synthesized using Passiflora caerulea fresh leaf extract and were characterized by UV-visible spectroscopy (UV–vis), X-ray diffractometer (XRD), Fourier transform infrared spectroscopy (FT-IR), Scanning electron microscopy (SEM), Energy dispersive analysis of x-ray (EDAX), Atomic force microscopy (AFM). Therefore, the study reveals an e

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20

Esther Nimshi, R., J. Judith Vijaya, B. Al-Najar, et al. "Multifunctional Core-Shell NiFe2O4 Shield with TiO2/rGO Nanostructures for Biomedical and Environmental Applications." Bioinorganic Chemistry and Applications 2022 (May 30, 2022): 1–21. http://dx.doi.org/10.1155/2022/4805490.

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Multifunctional core@shell nanoparticles have been synthesized in this paper through 3 stages: NiFe2O4 nanoparticles by microwave irradiation using Pedalium murex leaf extract as a fuel, core@shell NiFe2O4@TiO2 nanoparticles by sol-gel, and NiFe2O4@TiO2@rGO by sol-gel using preprepared reduced graphene oxide obtained by modified Hummer’s method. XRD analysis confirmed the presence of both cubic NiFe2O4 spinel and tetragonal TiO2 rutile phases, while Raman spectroscopy analysis displays both D and G bands (ID/IG = 1.04) associated with rGO. Morphological observations by HRTEM reveal a core-shel

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21

Woźniak, Marcin, Agata Płoska, Anna Siekierzycka, Lawrence W. Dobrucki, Leszek Kalinowski, and Iwona T. Dobrucki. "Molecular Imaging and Nanotechnology—Emerging Tools in Diagnostics and Therapy." International Journal of Molecular Sciences 23, no. 5 (2022): 2658. http://dx.doi.org/10.3390/ijms23052658.

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Personalized medicine is emerging as a new goal in the diagnosis and treatment of diseases. This approach aims to establish differences between patients suffering from the same disease, which allows to choose the most effective treatment. Molecular imaging (MI) enables advanced insight into molecule interactions and disease pathology, improving the process of diagnosis and therapy and, for that reason, plays a crucial role in personalized medicine. Nanoparticles are widely used in MI techniques due to their size, high surface area to volume ratio, and multifunctional properties. After conjugat

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22

Singh, Dilpreet, Russel Tonjam, Tanu Chaudhary, et al. "A Short Appraisal on Gold Nanoparticles: Recent Advances and Applications." Current Nanomedicine 11, no. 3 (2021): 168–76. http://dx.doi.org/10.2174/2468187312666211220122455.

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: Owing to their unique characteristics and diverse surface activities, gold nanoparticles (AuNPs) have been widely used in various fields of biology. The ease with which AuNPs can be functionalized makes it a useful platform for nanobiological assemblies containing oligonucleotides, antibodies, and proteins. AuNPs bioconjugates have also emerged as an interesting candidate for the development of novel biomaterials for the study of biological systems. AuNPs' flexibility has made them valuable in a variety of biomedical applications. The binding of analytes to AuNPs can change the physicochemic

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23

Li, Xiaotong, Minghong Jian, Yanhong Sun, Qunyan Zhu, and Zhenxin Wang. "The Peptide Functionalized Inorganic Nanoparticles for Cancer-Related Bioanalytical and Biomedical Applications." Molecules 26, no. 11 (2021): 3228. http://dx.doi.org/10.3390/molecules26113228.

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In order to improve their bioapplications, inorganic nanoparticles (NPs) are usually functionalized with specific biomolecules. Peptides with short amino acid sequences have attracted great attention in the NP functionalization since they are easy to be synthesized on a large scale by the automatic synthesizer and can integrate various functionalities including specific biorecognition and therapeutic function into one sequence. Conjugation of peptides with NPs can generate novel theranostic/drug delivery nanosystems with active tumor targeting ability and efficient nanosensing platforms for se

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24

Mochizuki, Chihiro, Junna Nakamura, and Michihiro Nakamura. "Development of Non-Porous Silica Nanoparticles towards Cancer Photo-Theranostics." Biomedicines 9, no. 1 (2021): 73. http://dx.doi.org/10.3390/biomedicines9010073.

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Nanoparticles have demonstrated several advantages for biomedical applications, including for the development of multifunctional agents as innovative medicine. Silica nanoparticles hold a special position among the various types of functional nanoparticles, due to their unique structural and functional properties. The recent development of silica nanoparticles has led to a new trend in light-based nanomedicines. The application of light provides many advantages for in vivo imaging and therapy of certain diseases, including cancer. Mesoporous and non-porous silica nanoparticles have high potent

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25

Aich, Udayanath. "Recent Advance in Synthesis and Application of Inorganic Glyconanoparticles as Bio-Therapeutics and Diagnostics Agents." Materials Science Forum 754 (April 2013): 1–19. http://dx.doi.org/10.4028/www.scientific.net/msf.754.1.

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Carbohydrates are attractive molecules for drug discovery because sugars are involved in many intricate human diseases including cancer and infectious diseases. Potential therapeutic and diagnostic benefits of sugar-based drugs, however, are offset by the poor pharmacologic properties of these molecules that include speedy serum clearance, poor cellular uptake, and the relatively high concentrations required for efficacy. To address these issues, carbohydrates are functionalized with nanocarrier as similar to peptides, proteins and DNA. Considering the vast relevance of Inorganic nanoparticles

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26

Nanda, Sitansu Sekhar, and Dong Kee Yi. "Recent Advances in Synergistic Effect of Nanoparticles and Its Biomedical Application." International Journal of Molecular Sciences 25, no. 6 (2024): 3266. http://dx.doi.org/10.3390/ijms25063266.

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The synergistic impact of nanomaterials is critical for novel intracellular and/or subcellular drug delivery systems of minimal toxicity. This synergism results in a fundamental bio/nano interface interaction, which is discussed in terms of nanoparticle translocation, outer wrapping, embedding, and interior cellular attachment. The morphology, size, surface area, ligand chemistry and charge of nanoparticles all play a role in translocation. In this review, we suggest a generalized mechanism to characterize the bio/nano interface, as we discuss the synergistic interaction between nanoparticles

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27

Vallet-Regí, María. "Mesoporous Silica Nanoparticles: Their Projection in Nanomedicine." ISRN Materials Science 2012 (August 16, 2012): 1–20. http://dx.doi.org/10.5402/2012/608548.

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Mesoporous silica nanoparticles are receiving growing attention by the scientific biomedical community. Among the different types of inorganic nanomaterials, mesoporous silica nanoparticles have emerged as promising multifunctional platforms for nanomedicine. Since their introduction in the drug delivery landscape in 2001, mesoporous materials for drug delivery are receiving growing scientific interest for their potential applications in the biotechnology and nanomedicine fields. The ceramic matrix efficiently protects entrapped guest molecules against enzymatic degradation or denaturation ind

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28

Lipengolts, Alexey A., Yulia A. Finogenova, Vsevolod A. Skribitsky, et al. "CT and MRI Imaging of Theranostic Bimodal Fe3O4@Au NanoParticles in Tumor Bearing Mice." International Journal of Molecular Sciences 24, no. 1 (2022): 70. http://dx.doi.org/10.3390/ijms24010070.

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Gold-containing nanoparticles are proven to be an effective radiosensitizer in the radiotherapy of tumors. Reliable imaging of nanoparticles in a tumor and surrounding normal tissues is crucial both for diagnostics and for nanoparticle application as radiosensitizers. The Fe3O4 core was introduced into gold nanoparticles to form a core/shell structure suitable for MRI imaging. The aim of this study was to assess the in vivo bimodal CT and MRI enhancement ability of novel core/shell Fe3O4@Au theranostic nanoparticles. Core/shell Fe3O4@Au nanoparticles were synthesized and coated with PEG and gl

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29

Chandrawanshi, Dr Ekta, and Dr Preeti Pandey. "Multifunctional Biocompatible Nanoparticles: Surface Modification and Synthesis of Layered Double Hydroxides for Biomedical Applications." Migration Letters 20, S13 (2023): 196–205. http://dx.doi.org/10.59670/ml.v20is13.6284.

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Layered Double Hydroxides (LDHs) are considered versatile materials owing to their distinctive features resulting from the isomorphous substitution of metal cations, namely M(II) and M(III), inside their octahedral locations. The LDH layer structure is characterized by a balanced arrangement of exchangeable hydrated or solvated anions within the interlayer and outer regions. This arrangement gives rise to a two-dimensional heterostructure with an ABAB pattern. Various metal cations have a role in LDHs composition, leading to their classification as hydrocalumites and hydrotalcite. Pristine-LDH

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30

Zenze, Mkhuseli, Aliscia Daniels, and Moganavelli Singh. "Dendrimers as Modifiers of Inorganic Nanoparticles for Therapeutic Delivery in Cancer." Pharmaceutics 15, no. 2 (2023): 398. http://dx.doi.org/10.3390/pharmaceutics15020398.

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The formulation of nanoscale systems with well-defined sizes and shapes is of great interest in applications such as drug and gene delivery, diagnostics and imaging. Dendrimers are polymers that have attracted interest due to their size, shape, branching length, amine density, and surface functionalities. These unique characteristics of dendrimers set them apart from other polymers, their ability to modify nanoparticles (NPs) for biomedical applications. Dendrimers are spherical with multiple layers over their central core, each representing a generation. Their amphiphilic nature and hollow st

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31

Yadav, Monika, Karishma Niveria, Tapas Sen, Indrajit Roy, and Anita K. Verma. "Targeting nonapoptotic pathways with functionalized nanoparticles for cancer therapy: current and future perspectives." Nanomedicine 16, no. 12 (2021): 1049–65. http://dx.doi.org/10.2217/nnm-2020-0443.

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Apoptotic death evasion is a hallmark of cancer progression. In this context, past decades have witnessed cytotoxic agents targeting apoptosis. However, owing to cellular defects in the apoptotic machinery, tumors develop resistance to apoptosis-based cancer therapies. Hence, targeting nonapoptotic cell-death pathways displays enhanced therapeutic success in apoptosis-defective tumor cells. Exploitation of multifunctional properties of engineered nanoparticles may allow cancer therapeutics to target yet unexplored pathways such as ferroptosis, autophagy and necroptosis. Necroptosis presents a

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32

Al Othman, Zeid A., Mohammad Mezbaul Alam, Mu Naushad, Inamuddin, and Mohd Farhan Khan. "Inorganic Nanoparticles and Nanomaterials Based on Titanium (Ti): Applications in Medicine." Materials Science Forum 754 (April 2013): 21–87. http://dx.doi.org/10.4028/www.scientific.net/msf.754.21.

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Nanomedicine is a relatively new field of science and technology. By interacting with biomolecules, therefore at nanoscale, nanotechnology opens up a vast field of research and application. Current and potential applications of nanotechnology in medicine range from research involving diagnostic devices, drug delivery vehicles to enhanced gene therapy and tissue engineering procedures. Its advantage over conventional medicine lies on its size. Operating at nanoscale allows to exploit physical properties different from those observed at microscale such as the volume/surface ratio. This allows dr

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Figueiredo, André Q., Carolina F. Rodrigues, Natanael Fernandes, Duarte de Melo-Diogo, Ilídio J. Correia, and André F. Moreira. "Metal-Polymer Nanoconjugates Application in Cancer Imaging and Therapy." Nanomaterials 12, no. 18 (2022): 3166. http://dx.doi.org/10.3390/nano12183166.

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Metallic-based nanoparticles present a unique set of physicochemical properties that support their application in different fields, such as electronics, medical diagnostics, and therapeutics. Particularly, in cancer therapy, the plasmonic resonance, magnetic behavior, X-ray attenuation, and radical oxygen species generation capacity displayed by metallic nanoparticles make them highly promising theragnostic solutions. Nevertheless, metallic-based nanoparticles are often associated with some toxicological issues, lack of colloidal stability, and establishment of off-target interactions. Therefo

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Gandhi, M., and M. Boghara. "Nanotheranostics: A powerful next-generation solution to tackle the chronic disease." IP International Journal of Comprehensive and Advanced Pharmacology 9, no. 1 (2024): 37–44. http://dx.doi.org/10.18231/j.ijcaap.2024.006.

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The use of nanotheranostics is the most advanced diagnostic and therapeutic techniques for a variety of disorders like cancer, IDs, HIV has drawn significant interest in the last ten years. Currently, various methods are use in the development of bright nanotheranostics, which mix bioactive concentrating on particular tissues and diagnostic capabilities. By using nanotheranostics, keeping track the therapy responses in real-time and therapeutic drugs is delivered. As a result, there is less chance of consuming too much medication. Several non-intrusive Imaging methods have been applied to trac

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Gheata, Adrian, Alessandra Spada, Manon Wittwer, et al. "Modulating the Surface Properties of Lithium Niobate Nanoparticles by Multifunctional Coatings Using Water-in-Oil Microemulsions." Nanomaterials 13, no. 3 (2023): 522. http://dx.doi.org/10.3390/nano13030522.

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Inorganic nanoparticles (NPs) have emerged as promising tools in biomedical applications, owing to their inherent physicochemical properties and their ease of functionalization. In all potential applications, the surface functionalization strategy is a key step to ensure that NPs are able to overcome the barriers encountered in physiological media, while introducing specific reactive moieties to enable post-functionalization. Silanization appears as a versatile NP-coating strategy, due to the biocompatibility and stability of silica, thus justifying the need for robust and well controlled sila

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Valverde, Thalita Marcolan, Viviane Martins Rebello dos Santos, Pedro Igor Macário Viana, et al. "Novel Fe3O4 Nanoparticles with Bioactive Glass–Naproxen Coating: Synthesis, Characterization, and In Vitro Evaluation of Bioactivity." International Journal of Molecular Sciences 25, no. 8 (2024): 4270. http://dx.doi.org/10.3390/ijms25084270.

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Immune response to biomaterials, which is intimately related to their surface properties, can produce chronic inflammation and fibrosis, leading to implant failure. This study investigated the development of magnetic nanoparticles coated with silica and incorporating the anti-inflammatory drug naproxen, aimed at multifunctional biomedical applications. The synthesized nanoparticles were characterized using various techniques that confirmed the presence of magnetite and the formation of a silica-rich bioactive glass (BG) layer. In vitro studies demonstrated that the nanoparticles exhibited bioa

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Estelrich, Joan, and M. Antònia Busquets. "Prussian Blue: A Nanozyme with Versatile Catalytic Properties." International Journal of Molecular Sciences 22, no. 11 (2021): 5993. http://dx.doi.org/10.3390/ijms22115993.

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Nanozymes, nanomaterials with enzyme-like activities, are becoming powerful competitors and potential substitutes for natural enzymes because of their excellent performance. Nanozymes offer better structural stability over their respective natural enzymes. In consequence, nanozymes exhibit promising applications in different fields such as the biomedical sector (in vivo diagnostics/and therapeutics) and the environmental sector (detection and remediation of inorganic and organic pollutants). Prussian blue nanoparticles and their analogues are metal–organic frameworks (MOF) composed of alternat

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Yang, Zhuofan, Hongcheng Song, and He Ding. "Advancements in implantable temperature sensors: Materials, mechanisms, and biological applications." Journal of Semiconductors 46, no. 1 (2025): 011609. https://doi.org/10.1088/1674-4926/24100003.

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Abstract Implantable temperature sensors are revolutionizing physiological monitoring and playing a crucial role in diagnostics, therapeutics, and life sciences research. This review classifies the materials used in these sensors into three categories: metal-based, inorganic semiconductor, and organic semiconductor materials. Metal-based materials are widely used in medical and industrial applications due to their linearity, stability, and reliability. Inorganic semiconductors provide rapid response times and high miniaturization potential, making them promising for biomedical and environmenta

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Bhattacharya, Dipsikha, Lipika Ray, Panchanan Pramanik, and Jitendra Kumar Pandey. "Recent Advances in Various Inorganic Nanoparticle Embedded Chitosan-based Multifunctional Materials for Wound Healing." Current Nanomedicine 13, no. 2 (2023): 75–90. http://dx.doi.org/10.2174/2468187313666230816095330.

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Abstract: Scarless wound management remains a clinical challenge worldwide because of its com-plicated and overlapping phases of inflammation, clearing, and regeneration. Among the currently available dressing materials, hydrogels have attracted emerging attention as potential wound dress-ing materials because of their specific properties, such as porosity, tissue-mimicking architecture, softness, and improved mechanical, biological as well as physicochemical properties. However, naturally driven hydrogels have shown several advantages over conventional hydrogels because of their biodegradabil

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Kausar, Ayesha, Ishaq Ahmad, Tingkai Zhao, Osamah Aldaghri, Khalid H. Ibnaouf, and M. H. Eisa. "Nanocomposite Foams of Polyurethane with Carbon Nanoparticles—Design and Competence towards Shape Memory, Electromagnetic Interference (EMI) Shielding, and Biomedical Fields." Crystals 13, no. 8 (2023): 1189. http://dx.doi.org/10.3390/cryst13081189.

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Polyurethane is a multipurpose polymer with indispensable physical characteristics and technical uses, such as films/coatings, fibers, and foams. The inclusion of nanoparticles in the polyurethane matrix has further enhanced the properties and potential of this important polymer. Research in this field has led to the design and exploration of polyurethane foams and polyurethane nanocomposite foams. This review article reflects vital aspects related to the fabrication, features, and applications of polyurethane nanocomposite foams. High-performance nanocellular polyurethanes have been produced

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Zimina, Tatiana M., Nikita O. Sitkov, Kamil G. Gareev, et al. "Biosensors and Drug Delivery in Oncotheranostics Using Inorganic Synthetic and Biogenic Magnetic Nanoparticles." Biosensors 12, no. 10 (2022): 789. http://dx.doi.org/10.3390/bios12100789.

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Magnetic nanocarriers have attracted attention in translational oncology due to their ability to be employed both for tumor diagnostics and therapy. This review summarizes data on applications of synthetic and biogenic magnetic nanoparticles (MNPs) in oncological theranostics and related areas. The basics of both types of MNPs including synthesis approaches, structure, and physicochemical properties are discussed. The properties of synthetic MNPs and biogenic MNPs are compared with regard to their antitumor therapeutic efficiency, diagnostic potential, biocompatibility, and cellular toxicity.

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Popova, Victoriya, Elena Dmitrienko, and Alexey Chubarov. "Magnetic Nanocomposites and Imprinted Polymers for Biomedical Applications of Nucleic Acids." Magnetochemistry 9, no. 1 (2022): 12. http://dx.doi.org/10.3390/magnetochemistry9010012.

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Magnetic nanocomposites (MNCs) combine the features of magnetic nanoparticles and a second material, which provide distinct physical, chemical, and biological properties. The magnetic core for nanocomposite synthesis is extensively used due to its high saturation magnetization, chemical stability, large surface area, and easy functionalization. Moreover, magnetic nanoparticles (MNPs) have great potential for magnetic resonance imaging (MRI), magnetic particle imaging (MPI), hyperthermia, and targeted drug and gene delivery by an external magnetic field. Numerous composing units exist, which le

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Bettini, Simona, Michela Ottolini, Donato Valli, et al. "Synthesis and Characterization of Gold Chiral Nanoparticles Functionalized by a Chiral Drug." Nanomaterials 13, no. 9 (2023): 1526. http://dx.doi.org/10.3390/nano13091526.

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Inorganic chiral nanoparticles are attracting more and more attention due to their peculiar optical properties and potential biological applications, such as bioimaging, therapeutics, and diagnostics. Among inorganic chiral nanoparticles, gold chiral nanostructures were demonstrated to be very interesting in this context, with good physical chemical stability and also the possibility to decorate the surface, improving biomedical application as the interaction with the bio-systems. Gold (Au) nanostructures were synthesized according to a seed-mediated procedure which envisages the use of cetylt

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Mazzaglia, Antonino, Norberto Micali, Luigi Monsù Scolaro, Maria Teresa Sciortino, Salvatore Sortino, and Valentina Villari. "Design of photosensitizer/cyclodextrin nanoassemblies: spectroscopy, intracellular delivery and photodamage." Journal of Porphyrins and Phthalocyanines 14, no. 08 (2010): 661–77. http://dx.doi.org/10.1142/s1088424610002562.

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The engineering of multifunctional nanoparticles carrying photosensitizer drugs (PS) and exposing binding groups for cellular receptors is of increasing interest in therapeutics and diagnostics applications. Natural and modified cyclodextrins (CDs) offer useful scaffolds to bind PS guests by supramolecular interactions. In particular, amphiphilic β-CDs, which form nanoaggregates of diverse shape and size according to the polarity of substituent groups on the rims, include in their different compartments as CD cavity, hydrophilic and hydrophobic portion, PS with different physicochemical proper

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Riviello, Gianna, Brendan Connor, Jake McBrearty, Gianna Rodriguez, and Xiao Hu. "Protein and Polysaccharide-Based Optical Materials for Biomedical Applications." International Journal of Molecular Sciences 25, no. 3 (2024): 1861. http://dx.doi.org/10.3390/ijms25031861.

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Recent advances in biomedical research, particularly in optical applications, have sparked a transformative movement towards replacing synthetic polymers with more biocompatible and sustainable alternatives. Most often made from plastics or glass, these materials ignite immune responses from the body, and their production is based on environmentally harsh oil-based processes. Biopolymers, including both polysaccharides and proteins, have emerged as a potential candidate for optical biomaterials due to their inherent biocompatibility, biodegradability, and sustainability, derived from their exi

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Ostheller, Maike-Elisa, Abdelrahman M. Abdelgawad, Naveen Kumar Balakrishnan, Ahmed H. Hassanin, Robert Groten, and Gunnar Seide. "Curcumin and Silver Doping Enhance the Spinnability and Antibacterial Activity of Melt-Electrospun Polybutylene Succinate Fibers." Nanomaterials 12, no. 2 (2022): 283. http://dx.doi.org/10.3390/nano12020283.

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Melt electrospinning is a polymer processing technology for the manufacture of microfibers and nanofibers. Additives are required to reduce the melt viscosity and increase its conductivity in order to minimize the fiber diameter, and can also impart additional beneficial properties. We investigated the preparation of polybutylene succinate (PBS) microfibers incorporating different weight percentages of two multifunctional additives (the organic dye curcumin and inorganic silver nanoparticles) using a single-nozzle laboratory-scale device. We determined the influence of these additives on the p

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Casulli, Taurino, Carrara, and Hayashita. "Integration Methods of Cyclodextrins on Gold and Carbon Electrodes for Electrochemical Sensors." C — Journal of Carbon Research 5, no. 4 (2019): 78. http://dx.doi.org/10.3390/c5040078.

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Cyclodextrins (CDs) are oligosaccharides composed of six (α), seven (β) or eight (γ) glucose units. Their inner hydrophobic cavity and hydrophilic external surface enable the formation of the “host-guest inclusion complex” with different organic or inorganic molecules showing high molecular selectivity. For these characteristics, CDs have many potential applications in electrochemical sensing. To enable CDs immobilization on the electrode surfaces, different chemical modifications are needed depending of the electrode material, while nanomaterials have been exploited to enhance the sensing sig

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Mohammed-Sadhakathullah, Ahammed H. M., Sofia Paulo-Mirasol, Juan Torras, and Elaine Armelin. "Advances in Functionalization of Bioresorbable Nanomembranes and Nanoparticles for Their Use in Biomedicine." International Journal of Molecular Sciences 24, no. 12 (2023): 10312. http://dx.doi.org/10.3390/ijms241210312.

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Bioresorbable nanomembranes (NMs) and nanoparticles (NPs) are powerful polymeric materials playing an important role in biomedicine, as they can effectively reduce infections and inflammatory clinical patient conditions due to their high biocompatibility, ability to physically interact with biomolecules, large surface area, and low toxicity. In this review, the most common bioabsorbable materials such as those belonging to natural polymers and proteins for the manufacture of NMs and NPs are reviewed. In addition to biocompatibility and bioresorption, current methodology on surface functionaliz

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Macchione, Micaela A., Dariana Aristizábal Bedoya, Eva Rivero-Buceta, Pablo Botella, and Miriam C. Strumia. "Mesoporous Silica and Oligo (Ethylene Glycol) Methacrylates-Based Dual-Responsive Hybrid Nanogels." Nanomaterials 12, no. 21 (2022): 3835. http://dx.doi.org/10.3390/nano12213835.

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Polymeric-inorganic hybrid nanomaterials have emerged as novel multifunctional platforms because they combine the intrinsic characteristics of both materials with unexpected properties that arise from synergistic effects. In this work, hybrid nanogels based on mesoporous silica nanoparticles, oligo (ethylene glycol) methacrylates, and acidic moieties were developed employing ultrasound-assisted free radical precipitation/dispersion polymerization. Chemical structure was characterized by infrared spectroscopy and nuclear magnetic resonance. Hydrodynamic diameters at different temperatures were

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Nigro, Alessandra, Michele Pellegrino, Marianna Greco, et al. "Dealing with Skin and Blood-Brain Barriers: The Unconventional Challenges of Mesoporous Silica Nanoparticles." Pharmaceutics 10, no. 4 (2018): 250. http://dx.doi.org/10.3390/pharmaceutics10040250.

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Advances in nanotechnology for drug delivery are fostering significant progress in medicine and diagnostics. The multidisciplinary nature of the nanotechnology field encouraged the development of innovative strategies and materials to treat a wide range of diseases in a highly specific way, which allows reducing the drug dosage and, consequently, improving the patient’s compliance. Due to their good biocompatibility, easy synthesis, and high versatility, inorganic frameworks represent a valid tool to achieve this aim. In this context, Mesoporous Silica Nanoparticles (MSNs) are emerging in the

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