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Статті в журналах з теми "Multidomaines"

Автор: Grafiati

Опубліковано: 1 жовтня 2022

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1

Maleki, Mohsen, and Eliot Fried. "Multidomain and ground state configurations of two-phase vesicles." Journal of The Royal Society Interface 10, no. 83 (June 6, 2013): 20130112. http://dx.doi.org/10.1098/rsif.2013.0112.

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A simple model is used to study the equilibrium of lipid domains on two-phase vesicles. Two classes of configurations are considered: multidomain and ground state configurations. For multidomain configurations, the vesicle has a finite number of identical lipid domains. For ground state configurations, the vesicle is fully phase separated into two coexisting domains. Whereas the volume enclosed by a vesicle with multidomains is fixed, the volume enclosed by a vesicle in a ground state is allowed to vary with the osmotic pressure. Guided by experimental observations, all domains are assumed to be spherical caps. In a multidomain configuration, the line tension is found to decrease with the number of domains present, with possible exceptions when the number of domains is very small. The importance of a critical osmotic pressure and a critical excess radius on ground state configurations is explored. Emphasis is placed on understanding the variations of these critical quantities with relevant parameters.

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2

Ha, Minho, Cheolung Cheong, Hanshin Seol, Bu-Geun Paik, Min-Jae Kim, and Young-Rae Jung. "Development of Efficient and Accurate Parallel Computation Algorithm Using Moving Overset Grids on Background Multi-Domains for Complex Two-Phase Flows." Applied Sciences 8, no. 10 (October 16, 2018): 1937. http://dx.doi.org/10.3390/app8101937.

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The goal of this study involves developing an efficient and accurate parallel computation method for two-phase flow problems including complex moving foreign bodies. The proposed parallel computing techniques are based on the moving body-fitted grids’ overset on background multidomains with grid-overlapping at their interface. First, the cavitation flow over the hemispherical head form is investigated using the two-phase flow solver, which is validated by comparing the numerical and experimental results. Subsequently, the parallel computing technique based on the multidomain method that divides the computational domain into several smaller subdomains is proposed to facilitate more efficient numerical simulations. At the interface of the subdomains, the grid-overlapping method is proposed for more accurate simulations. The illustrative computations indicate that the accuracy of the parallel computation combined with the grid-overlapping method on multidomains is identical to that of the serial computation based on a single block, albeit with a significant reduction in the computation time. Finally, the moving overset grid technique is combined with the background multidomain method and applied to simulate the gust flow that is generated by the pitching motions of the twin hydrofoils. The overset grid technique includes the following three sequential steps: hole-cutting, finding donor cells, and bilinear interpolation. The prediction results for the inflow gust generated by oscillating hydrofoils closely follow the measured results.

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3

Guo, Lian Shui, Jun Huang, Andres Tavor, and John E. Renaud. "Multidomain Topology Optimization for Crashworthiness Based on Hybrid Cellular Automata." Key Engineering Materials 486 (July 2011): 250–53. http://dx.doi.org/10.4028/www.scientific.net/kem.486.250.

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This research introduces a multidomain topology optimization algorithm for crashworthy structure undergoing large deformations. This technique makes use of the hybrid cellular automaton framework, which combines transient, non-linear finite-element analysis and local control rules acting on cells. The set of all cells defines the multidomains. Each subdomain has been defined by different material update rules according to specify constraint, and optimization iteration of each subdomain has been converged respectively during the optimal design process. The effectiveness of this technique is demonstrated through the design of a bumper-like structure. Result show that the new algorithm is suitable for practical applications. The case study presented demonstrates the potential significance of this work for a wide range of engineering design problems.

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4

de Oliveira, Amanda C. P., Rafael M. Ferreira, Maria Inês T. Ferro, Jesus A. Ferro, Caio Zamuner, Henrique Ferreira, and Alessandro M. Varani. "XAC4296 Is a Multifunctional and Exclusive Xanthomonadaceae Gene Containing a Fusion of Lytic Transglycosylase and Epimerase Domains." Microorganisms 10, no. 5 (May 11, 2022): 1008. http://dx.doi.org/10.3390/microorganisms10051008.

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Microorganisms have a limited and highly adaptable repertoire of genes capable of encoding proteins containing single or variable multidomains. The phytopathogenic bacteria Xanthomonas citri subsp. citri (X. citri) (Xanthomonadaceae family), the etiological agent of Citrus Canker (CC), presents a collection of multidomain and multifunctional enzymes (MFEs) that remains to be explored. Recent studies have shown that multidomain enzymes that act on the metabolism of the peptidoglycan and bacterial cell wall, belonging to the Lytic Transglycosylases (LTs) superfamily, play an essential role in X. citri biology. One of these LTs, named XAC4296, apart from the Transglycosylase SLT_2 and Peptidoglycan binding-like domains, contains an unexpected aldose 1-epimerase domain linked to the central metabolism; therefore, resembling a canonical MFE. In this work, we experimentally characterized XAC4296 revealing its role as an MFE and demonstrating its probable gene fusion origin and evolutionary history. The XAC4296 is expressed during plant-pathogen interaction, and the Δ4296 mutant impacts CC progression. Moreover, Δ4296 exhibited chromosome segregation and cell division errors, and sensitivity to ampicillin, suggesting not only LT activity but also that the XAC4296 may also contribute to resistance to β-lactams. However, both Δ4296 phenotypes can be restored when the mutant is supplemented with sucrose or glutamic acid as a carbon and nitrogen source, respectively; therefore, supporting the epimerase domain’s functional relationship with the central carbon and cell wall metabolism. Taken together, these results elucidate the role of XAC4296 as an MFE in X. citri, also bringing new insights into the evolution of multidomain proteins and antimicrobial resistance in the Xanthomonadaceae family.

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5

Valk, Vincent, Wieger Eeuwema, Fean D. Sarian, Rachel M. van der Kaaij та Lubbert Dijkhuizen. "Degradation of Granular Starch by the Bacterium Microbacterium aurum Strain B8.A Involves a Modular α-Amylase Enzyme System with FNIII and CBM25 Domains". Applied and Environmental Microbiology 81, № 19 (17 липня 2015): 6610–20. http://dx.doi.org/10.1128/aem.01029-15.

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ABSTRACTThe bacteriumMicrobacterium aurumstrain B8.A, originally isolated from a potato plant wastewater facility, is able to degrade different types of starch granules. Here we report the characterization of an unusually large, multidomainM. aurumB8.A α-amylase enzyme (MaAmyA). MaAmyA is a 1,417-amino-acid (aa) protein with a predicted molecular mass of 148 kDa. Sequence analysis of MaAmyA showed that its catalytic core is a family GH13_32 α-amylase with the typical ABC domain structure, followed by a fibronectin (FNIII) domain, two carbohydrate binding modules (CBM25), and another three FNIII domains. Recombinant expression and purification yielded an enzyme with the ability to degrade wheat and potato starch granules by introducing pores. Characterization of various truncated mutants of MaAmyA revealed a direct relationship between the presence of CBM25 domains and the ability of MaAmyA to form pores in starch granules, while the FNIII domains most likely function as stable linkers. At the C terminus, MaAmyA carries a 300-aa domain which is uniquely associated with large multidomain amylases; its function remains to be elucidated. We concluded thatM. aurumB8.A employs a multidomain enzyme system to initiate degradation of starch granules via pore formation.

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6

Zhou, Jianuan, Haibao Zhang, Jien Wu, Qiongguang Liu, Pinggen Xi, Jasmine Lee, Jinling Liao, Zide Jiang, and Lian-Hui Zhang. "A Novel Multidomain Polyketide Synthase Is Essential for Zeamine Production and the Virulence of Dickeya zeae." Molecular Plant-Microbe Interactions® 24, no. 10 (October 2011): 1156–64. http://dx.doi.org/10.1094/mpmi-04-11-0087.

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Dickeya zeae is the causal agent of the rice foot rot disease, but its mechanism of infection remains largely unknown. In this study, we identified and characterized a novel gene designated as zmsA. The gene encodes a large protein of 2,346 amino acids in length, which consists of multidomains arranged in the order of N-terminus, β-ketoacyl synthase, acyl transferase, acyl carrier protein, β-ketoacyl reductase, dehydratase. This multidomain structure and sequence alignment analysis suggest that ZmsA is a member of the polyketide synthase family. Mutation of zmsA abolished antimicrobial activity and attenuated the virulence of D. zeae. To determine the relationship between antimicrobial activity and virulence, active compounds were purified from D. zeae EC1 and were structurally characterized. This led to identification of two polyamino compounds, i.e., zeamine and zeamine II, that were phytotoxins and potent antibiotics. These results have established the essential role of ZmsA in zeamine biosynthesis and presented a new insight on the molecular mechanisms of D. zeae pathogenicity.

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7

Vázquez-Gómez, José. "Multidomain security." Computers & Security 13, no. 2 (April 1994): 161–84. http://dx.doi.org/10.1016/0167-4048(94)90065-5.

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8

Hertig, Samuel, Thomas D. Goddard, Graham T. Johnson, and Thomas E. Ferrin. "Multidomain Assembler (MDA) Generates Models of Large Multidomain Proteins." Biophysical Journal 108, no. 9 (May 2015): 2097–102. http://dx.doi.org/10.1016/j.bpj.2015.03.051.

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9

Adjeroh, Donald, Yue Jiang, Bing-Hua Jiang, and Jie Lin. "Network Analysis of Circular Permutations in Multidomain Proteins Reveals Functional Linkages for Uncharacterized Proteins." Cancer Informatics 13s5 (January 2014): CIN.S14059. http://dx.doi.org/10.4137/cin.s14059.

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Various studies have implicated different multidomain proteins in cancer. However, there has been little or no detailed study on the role of circular multidomain proteins in the general problem of cancer or on specific cancer types. This work represents an initial attempt at investigating the potential for predicting linkages between known cancer-associated proteins with uncharacterized or hypothetical multidomain proteins, based primarily on circular permutation (CP) relationships. First, we propose an efficient algorithm for rapid identification of both exact and approximate CPs in multidomain proteins. Using the circular relations identified, we construct networks between multidomain proteins, based on which we perform functional annotation of multidomain proteins. We then extend the method to construct subnetworks for selected cancer subtypes, and performed prediction of potential linkages between uncharacterized multidomain proteins and the selected cancer types. We include practical results showing the performance of the proposed methods.

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10

Klymko, Victor, Andriy Nadtochiy, David Sedorook, and Igor Ostrovskii. "Multidomain ferroelectric actuator." Journal of the Acoustical Society of America 128, no. 4 (October 2010): 2339. http://dx.doi.org/10.1121/1.3508279.

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11

Hegedűs, Ernő, and Sándor Hennel. "Többdimenziós (multidomain) hadműveletek." Hadtudomány 30, no. 2 (2020): 3–27. http://dx.doi.org/10.17047/hadtud.2020.30.2.3.

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12

Tsay, Jenngang, S. E. Schwarz, Shankar Raman, and J. S. Smith. "Multidomain gunn diodes." Microwave and Optical Technology Letters 3, no. 2 (February 1990): 54–60. http://dx.doi.org/10.1002/mop.4650030205.

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13

Ostrovskii, Igor, and Andriy Nadtochiy. "Multidomain ultrasonic transducers." Journal of Applied Physics 103, no. 10 (May 15, 2008): 104107. http://dx.doi.org/10.1063/1.2931028.

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14

Robinson, Cordelia C., Janet Rose, and Barbara Jackson. "Multidomain Assessment Instruments." Diagnostique 11, no. 3-4 (July 1986): 135–53. http://dx.doi.org/10.1177/073724778601100302.

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15

Moretti, F., A. R. Atti, S. Cesano, V. Morini, C. Forlani, V. Bernabei, A. Modenese, E. Dalmonte, and D. De Ronchi. "The use of MMSE to Identify Mild Cognitive Impairment (MCI). A Population-Based Study." European Psychiatry 24, S1 (January 2009): 1. http://dx.doi.org/10.1016/s0924-9338(09)71086-7.

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Aims:To evaluate the prevalence of MCI and its subtypes in the Faenza Project, using the Mini-Mental State Examination (MMSE).Methods:Subjects living in the municipality of Faenza were clinically assessed. The diagnosis of MCI was achieved according to international criteria using a double-step procedure: first, we excluded subjects with dementia, functional impairment and MMSE< 24, leaving 6,745 persons. Then, the performance in different cognitive domains was considered and scores less than 1.5 standard deviations below the age- and education-adjusted norms on MMSE were settled as cut-offs. Four subtypes were identified: amnestic MCI, single non-memory MCI, multidomains non-amnestic, multidomains amnestic MCI.Results:2,720 (40.3%) participants met MCI criteria. Prevalence were 4% (amnestic MCI), 26.5% (single non-memory MCI), 4.4% (multidomains amnestic MCI), and 5.4% (multidomains non-amnestic MCI).Conclusions:MCI is common among Italian elderly. In our study prevalence are higher than reported in other population-based studies. The use of MMSE with different operational criteria, diverse sampling and assessment procedure might explain such discrepancy. The role of MMSE to identify persons with mild cognitive deficits deserves concerns. However, MMSE is largely used in both clinical practice and research and has been suggested as a useful screening tool for assessing the degree of cognitive impairment in the guidelines for the Report of the Quality Standards Subcommittee of the American Academy of Neurology.

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16

Cardelli, E., M. Carpentieri, A. Faba, and G. Finocchio. "Modeling of hysteresis in magnetic multidomains." Physica B: Condensed Matter 435 (February 2014): 62–65. http://dx.doi.org/10.1016/j.physb.2013.06.009.

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17

Xu, Teng, Qinxiang Xia, Xiaoyu Wu, Jiaqi Ran, Feng Gong, and Chunying Lee. "Influence of Hydraulic Domain on Vibration Control and Overload Prediction of High-Speed Punching Press: Multidomain Modelling and Experiment." Shock and Vibration 2019 (September 19, 2019): 1–9. http://dx.doi.org/10.1155/2019/8547104.

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By the multidomain modelling method, the vibration of a high-speed punching press was modelled and simulated, and the influence of the hydraulic system on the vibration of the punching press and the protection efficiency of the punching press under the overload condition was discussed. The multidomain simulation results were compared with the experimental results to the validity of the multidomain model on a punching press with a hydraulic system for vibration reduction function.

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18

Dimitrijevic, D. D., B. Maglaris, and R. R. Boorstyn. "Routing in multidomain networks." IEEE/ACM Transactions on Networking 2, no. 3 (June 1994): 252–62. http://dx.doi.org/10.1109/90.311623.

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19

Nadtochiy, Andriy, and Igor Ostrovskii. "Wideband multidomain ultrasonic transducer." Journal of the Acoustical Society of America 125, no. 4 (April 2009): 2520. http://dx.doi.org/10.1121/1.4783477.

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20

Erdynast, Albert, Wendy Chen, and Amanda Ikin. "Criteria for multidomain research." Behavioral Development Bulletin 21, no. 1 (April 2016): 74–87. http://dx.doi.org/10.1037/bdb0000016.

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21

Povitsky, A., and M. Wolfshtein. "Multidomain implicit numerical scheme." International Journal for Numerical Methods in Fluids 25, no. 5 (September 15, 1997): 547–66. http://dx.doi.org/10.1002/(sici)1097-0363(19970915)25:5<547::aid-fld576>3.0.co;2-v.

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22

Fousek, J., and L. E. Cross. "Engineering multidomain ferroic samples." Ferroelectrics 252, no. 1 (February 2001): 171–80. http://dx.doi.org/10.1080/00150190108016254.

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23

Valle-Orero, Jessica, Jaime Andrés Rivas-Pardo, and Ionel Popa. "Multidomain proteins under force." Nanotechnology 28, no. 17 (April 4, 2017): 174003. http://dx.doi.org/10.1088/1361-6528/aa655e.

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24

van der Rest, M., and R. Garrone. "Collagens as multidomain proteins." Biochimie 72, no. 6-7 (June 1990): 473–84. http://dx.doi.org/10.1016/0300-9084(90)90071-n.

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25

Gaudiello, Antonio, and Ali Sili. "Asymptotic analysis of the eigenvalues of an elliptic problem in an anisotropic thin multidomain." Proceedings of the Royal Society of Edinburgh: Section A Mathematics 141, no. 4 (July 15, 2011): 739–54. http://dx.doi.org/10.1017/s0308210510000521.

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We study, via an asymptotic analysis, an elliptic eigenvalue problem in a 1D–1D multidomain and in a 1D–2D multidomain filled with anisotropic material. The corresponding isotropic cases were considered in a previous work by Gaudiello and Sili.

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26

Rolland, Yves, Philipe de Souto Barreto, Mathieu Maltais, Sophie Guyonnet, Christelle Cantet, Sandrine Andrieu, and Bruno Vellas. "Effect of Long-Term Omega 3 Polyunsaturated Fatty Acid Supplementation with or without Multidomain Lifestyle Intervention on Muscle Strength in Older Adults: Secondary Analysis of the Multidomain Alzheimer Preventive Trial (MAPT)." Nutrients 11, no. 8 (August 16, 2019): 1931. http://dx.doi.org/10.3390/nu11081931.

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Background: The benefits of long-term omega 3 polyunsaturated fatty acid (ω3-PUFA) supplementation on muscle strength in older adults remains to be investigated. Objectives: We assessed the effect of ω3-PUFA supplementation and a multidomain (physical activity, cognitive training, and nutritional advice), alone or in combination, compared with placebo, on muscle strength. We also hypothesized that ω3-PUFA supplementation resulted in additional benefit in participants with a low docosahexaenoic acid (DHA)/eicosapentaenoic acid (EPA) erythrocyte level at baseline and high adherence to the multidomain intervention sessions. Design: We performed secondary analyses of the Multidomain Alzheimer Preventive Trial (MAPT), a 3-year, multicenter, randomized, placebo-controlled trial with four parallel groups. Participants were non-demented, aged 70 years or older. They were recruited in 13 memory clinics in France and Monaco between 30 May 2008 and 24 February 2011. Participants were randomly assigned to either ω3-PUFA alone (two capsules a day providing a total daily dose of 800 mg DHA and 225 mg EPA), ω3-PUFA plus the multidomain intervention (43 group sessions integrating advice for physical activity (PA), and nutrition, cognitive training, and three preventive consultations), the multidomain intervention plus placebo, or placebo alone. Our primary outcome was the change from baseline to 36 months of the muscle strength assessed with the repeated chair stand test and handgrip strength. Results: A total of 1680 participants (75.34 years ± 4.42) were randomized. In the modified intention-to-treat population (n = 1679), no significant differences at 3-year follow-up were observed in the repeated chair stand test score between any of the three intervention groups and the placebo group. The between-group differences compared with placebo were −0.05388 (−0.6800 to 0.5723; Standard Error, SE = 0.3192; p = 0.8660) for the ω3-PUFA group, −0.3936 (−1.0217 to 0.2345; SE = 0.3180; p = 0.2192) for the multidomain intervention plus placebo group, and −0.6017 (−1.2255 to 0.02222; SE = 0.2092; p = 0.3202) for the combined intervention group. No significant effect was also found for the handgrip strength. Sensitivity analyses performed among participants with low (DHA+EPA) erythrocyte level at baseline (first quartile vs. others) or highly adherent participants (≥75% of the multidomain intervention sessions) revealed similar results. Conclusion: Low dose ω3-PUFA supplementation, either alone or in combination with a multidomain lifestyle intervention comprising physical activity counselling, had no significant effects on muscle strength over 3 years in elderly people.

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27

Kadokura, Hiroshi, Yui Dazai, Yo Fukuda, Naoya Hirai, Orie Nakamura, and Kenji Inaba. "Observing the nonvectorial yet cotranslational folding of a multidomain protein, LDL receptor, in the ER of mammalian cells." Proceedings of the National Academy of Sciences 117, no. 28 (June 29, 2020): 16401–8. http://dx.doi.org/10.1073/pnas.2004606117.

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Proteins have evolved by incorporating several structural units within a single polypeptide. As a result, multidomain proteins constitute a large fraction of all proteomes. Their domains often fold to their native structures individually and vectorially as each domain emerges from the ribosome or the protein translocation channel, leading to the decreased risk of interdomain misfolding. However, some multidomain proteins fold in the endoplasmic reticulum (ER) nonvectorially via intermediates with nonnative disulfide bonds, which were believed to be shuffled to native ones slowly after synthesis. Yet, the mechanism by which they fold nonvectorially remains unclear. Using two-dimensional (2D) gel electrophoresis and a conformation-specific antibody that recognizes a correctly folded domain, we show here that shuffling of nonnative disulfide bonds to native ones in the most N-terminal region of LDL receptor (LDLR) started at a specific timing during synthesis. Deletion analysis identified a region on LDLR that assisted with disulfide shuffling in the upstream domain, thereby promoting its cotranslational folding. Thus, a plasma membrane-bound multidomain protein has evolved a sequence that promotes the nonvectorial folding of its upstream domains. These findings demonstrate that nonvectorial folding of a multidomain protein in the ER of mammalian cells is more coordinated and elaborated than previously thought. Thus, our findings alter our current view of how a multidomain protein folds nonvectorially in the ER of living cells.

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28

Xiao, Xiancui, Xiangwei Zheng, and Yuang Zhang. "A Multidomain Survivable Virtual Network Mapping Algorithm." Security and Communication Networks 2017 (2017): 1–12. http://dx.doi.org/10.1155/2017/5258010.

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Although the existing networks are more often deployed in the multidomain environment, most of existing researches focus on single-domain networks and there are no appropriate solutions for the multidomain virtual network mapping problem. In fact, most studies assume that the underlying network can operate without any interruption. However, physical networks cannot ensure the normal provision of network services for external reasons and traditional single-domain networks have difficulties to meet user needs, especially for the high security requirements of the network transmission. In order to solve the above problems, this paper proposes a survivable virtual network mapping algorithm (IntD-GRC-SVNE) that implements multidomain mapping in network virtualization. IntD-GRC-SVNE maps the virtual communication networks onto different domain networks and provides backup resources for virtual links which improve the survivability of the special networks. Simulation results show that IntD-GRC-SVNE can not only improve the survivability of multidomain communications network but also render the network load more balanced and greatly improve the network acceptance rate due to employment of GRC (global resource capacity).

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29

Yokoh, Keisuke, Tomomitsu Muraishi, Song Min Nam, Hirofumi Kakemoto, Takaaki Tsurumi, Hirohiko Kumagai, and Satoshi Wada. "Introduction of Fine Engineered Domain Configuration into Potassium Niobate Single Crystals." Key Engineering Materials 350 (October 2007): 89–92. http://dx.doi.org/10.4028/www.scientific.net/kem.350.89.

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To induce fine engineered domain configurations into potassium niobate (KNbO3) single crystals, two kinds of methods were performed, i.e., (1) high DC electric field exposure along the opposite direction of polarization of KNbO3 single-domain crystals at room temperature, and (2) introduction of randomly oriented fine domain configuration by heat treatment at 700 °C and then high DC electric field exposure along [001]c direction of KNbO3 multidomain crystals at room temperature. When the method (1) was performed, finally, the poled KNbO3 crystals became to single-domain state again through the formation of multidomain state. On the other hand, the KNbO3 multidomain crystals were obtained by using the method (2), and an enhancement of piezoelectric-related properties was observed.

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30

Cai, Chuanbing, and Hiroyuki Fujimoto. "Effects of Nd123/MgO Thin Film and MgO Single-crystal Seeds in Isothermal Solidification of YBaCuO/Ag." Journal of Materials Research 15, no. 8 (August 2000): 1742–48. http://dx.doi.org/10.1557/jmr.2000.0251.

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The seeding effects of (001) Nd123/MgO thin films and MgO single crystals were studied in isothermal solidification of YBa2Cu3Oy composite with the additions of 40 mol% Y2BaCuO5, 10 wt% Ag, and 0.5 wt% Pt. Seeding with the Nd123/MgO thin film resulted in single-domain growth of Y123 crystal with a stable growth along the “100”?direction, while seeding with MgO single crystal produced multidomain growth in which the dominant growth facet is rotated 45° about (100) plane of MgO. Multidomain growth in MgO seeded sample was suppressed by decreasing undercooling degree. The effects of undercooling degree and seed size on multidomain growth are discussed in view of classical nucleation and growth theory.

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31

Thomasen, F. Emil, and Kresten Lindorff-Larsen. "Conformational ensembles of intrinsically disordered proteins and flexible multidomain proteins." Biochemical Society Transactions 50, no. 1 (February 7, 2022): 541–54. http://dx.doi.org/10.1042/bst20210499.

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Intrinsically disordered proteins (IDPs) and multidomain proteins with flexible linkers show a high level of structural heterogeneity and are best described by ensembles consisting of multiple conformations with associated thermodynamic weights. Determining conformational ensembles usually involves the integration of biophysical experiments and computational models. In this review, we discuss current approaches to determine conformational ensembles of IDPs and multidomain proteins, including the choice of biophysical experiments, computational models used to sample protein conformations, models to calculate experimental observables from protein structure, and methods to refine ensembles against experimental data. We also provide examples of recent applications of integrative conformational ensemble determination to study IDPs and multidomain proteins and suggest future directions for research in the field.

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32

MOON, Tom, and Ronald T. MERRILL. "Magnetic screening in multidomain material." Journal of geomagnetism and geoelectricity 38, no. 9 (1986): 883–94. http://dx.doi.org/10.5636/jgg.38.883.

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Roy, Amitava, Duy P. Hua, and Carol Beth Post. "Analysis of Multidomain Protein Dynamics." Journal of Chemical Theory and Computation 12, no. 1 (December 17, 2015): 274–80. http://dx.doi.org/10.1021/acs.jctc.5b00796.

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34

Klaasse, J. C. P., Y. Janssen, N. P. Duong, E. Brück, K. H. J. Buschow, and F. R. de Boer. "Multidomain phenomena in 38 tesla." Physica B: Condensed Matter 346-347 (April 2004): 165–68. http://dx.doi.org/10.1016/j.physb.2004.01.042.

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35

Coppock, Donald L., and Colin Thorpe. "Multidomain Flavin-Dependent Sulfhydryl Oxidases." Antioxidants & Redox Signaling 8, no. 3-4 (March 2006): 300–311. http://dx.doi.org/10.1089/ars.2006.8.300.

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36

Ostrovskii, Igor V., and Andriy B. Nadtochiy. "60 MHz multidomain ultrasonic transducer." Journal of the Acoustical Society of America 121, no. 5 (May 2007): 3175. http://dx.doi.org/10.1121/1.4782312.

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37

Chizhik, A., Andrzej Stupakiewicz, Arcady Zhukov, A. Maziewski, and Julian Gonzalez. "Multidomain Structures in Magnetic Microwire." IEEE Transactions on Magnetics 51, no. 11 (November 2015): 1–4. http://dx.doi.org/10.1109/tmag.2015.2428710.

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38

Schadt, M., and H. Seiberle. "Optical patterning of multidomain LCDs." Journal of the Society for Information Display 5, no. 4 (1997): 367. http://dx.doi.org/10.1889/1.1985180.

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39

Yang, Yin, Weiwei Xu, Xiaohu Guo, Kun Zhou, and Baining Guo. "Boundary-Aware Multidomain Subspace Deformation." IEEE Transactions on Visualization and Computer Graphics 19, no. 10 (October 2013): 1633–45. http://dx.doi.org/10.1109/tvcg.2013.12.

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40

Kioussis, Dimitris. "Multidomain proteins — structure and evolution." Trends in Genetics 3 (January 1987): 56–57. http://dx.doi.org/10.1016/0168-9525(87)90170-3.

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41

Zhou, Xiaogen, Jun Hu, Chengxin Zhang, Guijun Zhang, and Yang Zhang. "Assembling multidomain protein structures through analogous global structural alignments." Proceedings of the National Academy of Sciences 116, no. 32 (July 24, 2019): 15930–38. http://dx.doi.org/10.1073/pnas.1905068116.

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Most proteins exist with multiple domains in cells for cooperative functionality. However, structural biology and protein folding methods are often optimized for single-domain structures, resulting in a rapidly growing gap between the improved capability for tertiary structure determination and high demand for multidomain structure models. We have developed a pipeline, termed DEMO, for constructing multidomain protein structures by docking-based domain assembly simulations, with interdomain orientations determined by the distance profiles from analogous templates as detected through domain-level structure alignments. The pipeline was tested on a comprehensive benchmark set of 356 proteins consisting of 2–7 continuous and discontinuous domains, for which DEMO generated models with correct global fold (TM-score > 0.5) for 86% of cases with continuous domains and for 100% of cases with discontinuous domain structures, starting from randomly oriented target-domain structures. DEMO was also applied to reassemble multidomain targets in the CASP12 and CASP13 experiments using domain structures excised from the top server predictions, where the full-length DEMO models showed a significantly improved quality over the original server models. Finally, sparse restraints of mass spectrometry-generated cross-linking data and cryo-EM density maps are incorporated into DEMO, resulting in improvements in the average TM-score by 6.3% and 12.5%, respectively. The results demonstrate an efficient approach to assembling multidomain structures, which can be easily used for automated, genome-scale multidomain protein structure assembly.

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42

Kawagoe, Soichiro, Koichiro Ishimori, and Tomohide Saio. "Structural and Kinetic Views of Molecular Chaperones in Multidomain Protein Folding." International Journal of Molecular Sciences 23, no. 5 (February 24, 2022): 2485. http://dx.doi.org/10.3390/ijms23052485.

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Despite recent developments in protein structure prediction, the process of the structure formation, folding, remains poorly understood. Notably, folding of multidomain proteins, which involves multiple steps of segmental folding, is one of the biggest questions in protein science. Multidomain protein folding often requires the assistance of molecular chaperones. Molecular chaperones promote or delay the folding of the client protein, but the detailed mechanisms are still unclear. This review summarizes the findings of biophysical and structural studies on the mechanism of multidomain protein folding mediated by molecular chaperones and explains how molecular chaperones recognize the client proteins and alter their folding properties. Furthermore, we introduce several recent studies that describe the concept of kinetics–activity relationships to explain the mechanism of functional diversity of molecular chaperones.

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43

Tsunekawa, Shin, Atsuo Kasuya, Yuichiro Nishina, and Tsuguo Fukuda. "Ferroelastic Multidomains in LaNbO₄ Crystals." Materials Transactions, JIM 37, no. 4 (1996): 650–54. http://dx.doi.org/10.2320/matertrans1989.37.650.

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44

Forcadel, Nicolas, and Zhiping Rao. "Singular Perturbation of Optimal Control Problems on MultiDomains." SIAM Journal on Control and Optimization 52, no. 5 (January 2014): 2917–43. http://dx.doi.org/10.1137/130916709.

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45

WEI, GUO-WEI. "MULTISCALE, MULTIPHYSICS AND MULTIDOMAIN MODELS I: BASIC THEORY." Journal of Theoretical and Computational Chemistry 12, no. 08 (December 2013): 1341006. http://dx.doi.org/10.1142/s021963361341006x.

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This work extends our earlier two-domain formulation of a differential geometry based multiscale paradigm into a multidomain theory, which endows us the ability to simultaneously accommodate multiphysical descriptions of aqueous chemical, physical and biological systems, such as fuel cells, solar cells, nanofluidics, ion channels, viruses, RNA polymerases, molecular motors, and large macromolecular complexes. The essential idea is to make use of the differential geometry theory of surfaces as a natural means to geometrically separate the macroscopic domain of solvent from the microscopic domain of solute, and dynamically couple continuum and discrete descriptions. Our main strategy is to construct energy functionals to put on an equal footing of multiphysics, including polar (i.e. electrostatic) solvation, non-polar solvation, chemical potential, quantum mechanics, fluid mechanics, molecular mechanics, coarse grained dynamics, and elastic dynamics. The variational principle is applied to the energy functionals to derive desirable governing equations, such as multidomain Laplace–Beltrami (LB) equations for macromolecular morphologies, multidomain Poisson–Boltzmann (PB) equation or Poisson equation for electrostatic potential, generalized Nernst–Planck (NP) equations for the dynamics of charged solvent species, generalized Navier–Stokes (NS) equation for fluid dynamics, generalized Newton's equations for molecular dynamics (MD) or coarse-grained dynamics and equation of motion for elastic dynamics. Unlike the classical PB equation, our PB equation is an integral-differential equation due to solvent–solute interactions. To illustrate the proposed formalism, we have explicitly constructed three models, a multidomain solvation model, a multidomain charge transport model and a multidomain chemo-electro-fluid-MD-elastic model. Each solute domain is equipped with distinct surface tension, pressure, dielectric function, and charge density distribution. In addition to long-range Coulombic interactions, various non-electrostatic solvent–solute interactions are considered in the present modeling. We demonstrate the consistency between the non-equilibrium charge transport model and the equilibrium solvation model by showing the systematical reduction of the former to the latter at equilibrium. This paper also offers a brief review of the field.

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46

Gan, Sheng Ke, and Feng Bin Wang. "An Extended UCON Model Supporting Distributed Multidomain Applications." Advanced Materials Research 433-440 (January 2012): 5616–19. http://dx.doi.org/10.4028/www.scientific.net/amr.433-440.5616.

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This paper presents security rules summarized from the analysis of an distributed multidomain application. The paper proposes extensions to the core UCON model to address typical problems and requirements in the distributed multidomain environment such as: dynamic attributes, delegation authorization mechanism. The paper gives the definition of the important part of the extended UCON model such as: the basic sets, the system assertions and the actions.

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47

Laursen, Nick S., Robert H. E. Friesen, Xueyong Zhu, Mandy Jongeneelen, Sven Blokland, Jan Vermond, Alida van Eijgen, et al. "Universal protection against influenza infection by a multidomain antibody to influenza hemagglutinin." Science 362, no. 6414 (November 1, 2018): 598–602. http://dx.doi.org/10.1126/science.aaq0620.

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Broadly neutralizing antibodies against highly variable pathogens have stimulated the design of vaccines and therapeutics. We report the use of diverse camelid single-domain antibodies to influenza virus hemagglutinin to generate multidomain antibodies with impressive breadth and potency. Multidomain antibody MD3606 protects mice against influenza A and B infection when administered intravenously or expressed locally from a recombinant adeno-associated virus vector. Crystal and single-particle electron microscopy structures of these antibodies with hemagglutinins from influenza A and B viruses reveal binding to highly conserved epitopes. Collectively, our findings demonstrate that multidomain antibodies targeting multiple epitopes exhibit enhanced virus cross-reactivity and potency. In combination with adeno-associated virus–mediated gene delivery, they may provide an effective strategy to prevent infection with influenza virus and other highly variable pathogens.

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48

Bott, Hall, Madero, Glenn, Fuseya, Gills, and Gray. "Face-to-Face and Digital Multidomain Lifestyle Interventions to Enhance Cognitive Reserve and Reduce Risk of Alzheimer’s Disease and Related Dementias: A Review of Completed and Prospective Studies." Nutrients 11, no. 9 (September 19, 2019): 2258. http://dx.doi.org/10.3390/nu11092258.

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: Background: Currently, there is no pharmaceutical intervention to treat or delay pathological cognitive decline or Alzheimer’s disease and related dementias (ADRD). Multidomain lifestyle interventions are increasingly being studied as a non-pharmacological solution to enhance cognitive reserve, maintain cognition, and reduce the risk of or delay ADRD. Review of completed and prospective face-to-face (FTF) and digital multidomain interventions provides an opportunity to compare studies and informs future interventions and study design. Methods: Electronic databases (PubMed, PsycINFO, clinicaltrials.gov and NIH RePORTER) were searched for multidomain lifestyle programs. Studies were included if the program (1) included a control group, (2) included at least 3 interventions, (3) were at least 6 months in duration, and (4) included measurement of cognitive performance as an outcome. Results: In total, 17 multidomain lifestyle programs aimed at enhancing cognitive reserve and reducing risk of ADRD were found. Thirteen programs are FTF in intervention delivery, with 3 FTF programs replicating the FINGER protocol as part of the World Wide Fingers Consortium. Four programs are delivered digitally (website, Web application, or mobile app). Program characteristics (e.g., target population, duration, frequency, outcomes, and availability) and results of completed and prospective studies are reviewed and discussed. Conclusion: This review updates and discusses completed and current multidomain lifestyle interventions aimed at enhancing cognitive reserve and reducing risk of ADRD. A growing number of international studies are investigating the efficacy and utility of these programs in both FTF and digital contexts. While a diversity of study designs and interventions exist, FTF and digital programs that build upon the foundational work of the FINGER protocol have significant potential to enhance cognitive reserve and reduce risk of ADRD.

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Xu, Teng, Qinxiang Xia, Xiaobin Long, and Gianluca Buffa. "Vibration Control of a High-Speed Precision Servo Numerically Controlled Punching Press: Multidomain Simulation and Experiments." Shock and Vibration 2017 (2017): 1–17. http://dx.doi.org/10.1155/2017/4593546.

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A three-degree-of-freedom mathematical vibration model of a high-speed punching press was developed in order to explore the vibration modes of the punching press. A multidomain model of the punching press was established to predict the kinematic state during different conditions, as well as the effects of load fluctuation on the motor speed. Experimental measurements of the acceleration of the punching press were carried out. The results comparison reveals that the multidomain model is consistent with the vibration model and the experimental measurements. Modal analysis and structure modification of the punching press were conducted. The foundation at the base of the punching press was improved against excess of vibration. The effects of the dimensions of the foundation on the vibration were discussed with the aid of the multidomain model. Finally, proper foundation design, able to reduce the vibration, was obtained.

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50

Yang, Jing, Lianwei Qu, and Yong Wang. "Multidomain Fusion Data Privacy Security Framework." Wireless Communications and Mobile Computing 2021 (December 20, 2021): 1–26. http://dx.doi.org/10.1155/2021/8492223.

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With the collaborative collection of the Internet of Things (IoT) in multidomain, the collected data contains richer background knowledge. However, this puts forward new requirements for the security of data publishing. Furthermore, traditional statistical methods ignore the attributes sensitivity and the relationship between attributes, which makes multimodal statistics among attributes in multidomain fusion data set based on sensitivity difficult. To solve the above problems, this paper proposes a multidomain fusion data privacy security framework. First, based on attributes recognition, classification, and grading model, determine the attributes sensitivity and relationship between attributes to realize the multimode data statistics. Second, combine them with the different modal histograms to build multimodal histograms. Finally, we propose a privacy protection model to ensure the security of data publishing. The experimental analysis shows that the framework can not only build multimodal histograms of different microdomain attribute sets but also effectively reduce frequency query error.

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